gamma-aminobutyric acid has been researched along with Carcinoma, Renal Cell in 3 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Carcinoma, Renal Cell: A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the renal cell carcinoma, in contrast with GBM, (13) C multiplets of γ-aminobutyric acid (GABA) differed from its precursor glutamate, suggesting that GABA did not derive from a common glutamate precursor pool." | 1.38 | Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors. ( Bachoo, RM; Cho, SK; Choi, C; Deberardinis, RJ; Good, LB; Hatanpaa, KJ; Jindal, A; Kapur, P; Maher, EA; Malloy, CR; Marin-Valencia, I; Mashimo, T; Mickey, B; Pascual, JM; Raisanen, J; Rakheja, D; Sun, X; Takahashi, M; Togao, O; Vemireddy, V, 2012) |
| "Gamma-aminobutyric acid (GABA) was first discovered as an inhibitory neurotransmitter in the central nervous system (CNS) and has been reported to have a variety of functions, including regulation of cell division, cell differentiation and maturation, and to be involved in the development of certain cancers outside the CNS." | 1.34 | Invasive ability of human renal cell carcinoma cell line Caki-2 is accelerated by gamma-aminobutyric acid, via sustained activation of ERK1/2 inducible matrix metalloproteinases. ( Azuma, H; Inamoto, T; Katsuoka, Y; Kiyama, S; Kotake, Y; Sakamoto, T; Ubai, T; Watanabe, M, 2007) |
| "In the present study, using the human renal cell carcinoma cell line Caki-2, we demonstrated that GABA stimulation significantly increased the expression of MMP-2 and -9 and subsequently increased the invasive activity of the cancer cells." | 1.34 | Invasive ability of human renal cell carcinoma cell line Caki-2 is accelerated by gamma-aminobutyric acid, via sustained activation of ERK1/2 inducible matrix metalloproteinases. ( Azuma, H; Inamoto, T; Katsuoka, Y; Kiyama, S; Kotake, Y; Sakamoto, T; Ubai, T; Watanabe, M, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Marin-Valencia, I | 1 |
| Cho, SK | 1 |
| Rakheja, D | 1 |
| Hatanpaa, KJ | 1 |
| Kapur, P | 1 |
| Mashimo, T | 1 |
| Jindal, A | 1 |
| Vemireddy, V | 1 |
| Good, LB | 1 |
| Raisanen, J | 1 |
| Sun, X | 1 |
| Mickey, B | 1 |
| Choi, C | 1 |
| Takahashi, M | 1 |
| Togao, O | 1 |
| Pascual, JM | 1 |
| Deberardinis, RJ | 1 |
| Maher, EA | 1 |
| Malloy, CR | 1 |
| Bachoo, RM | 1 |
| Oefelein, MG | 1 |
| Bayazit, Y | 1 |
| Inamoto, T | 1 |
| Azuma, H | 1 |
| Sakamoto, T | 1 |
| Kiyama, S | 1 |
| Ubai, T | 1 |
| Kotake, Y | 1 |
| Watanabe, M | 1 |
| Katsuoka, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment Development of Triheptanoin for Glucose Transporter Type I Deficiency[NCT02021526] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2015-12-31 | Withdrawn (stopped due to NIH funding resulted in new clinical trial) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for gamma-aminobutyric acid and Carcinoma, Renal Cell
| Article | Year |
|---|---|
Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors.
Topics: Animals; Brain Neoplasms; Carcinoma, Renal Cell; Citric Acid Cycle; Disease Models, Animal; gamma-Am | 2012 |
Chronic pain syndrome after laparoscopic radical nephrectomy.
Topics: Acetates; Aged; Amines; Analgesics; Analgesics, Opioid; Carcinoma, Renal Cell; Carcinoma, Transition | 2003 |
Invasive ability of human renal cell carcinoma cell line Caki-2 is accelerated by gamma-aminobutyric acid, via sustained activation of ERK1/2 inducible matrix metalloproteinases.
Topics: Carcinoma, Renal Cell; Cell Line, Tumor; Enzyme Activation; gamma-Aminobutyric Acid; Humans; Kidney | 2007 |