gamma-aminobutyric acid has been researched along with Canavan Disease in 2 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Canavan Disease: A rare neurodegenerative condition of infancy or childhood characterized by white matter vacuolization and demeylination that gives rise to a spongy appearance. Aspartoacylase deficiency leads to an accumulation of N-acetylaspartate in astrocytes. Inheritance may be autosomal recessive or the illness may occur sporadically. This illness occurs more frequently in individuals of Ashkenazic Jewish descent. The neonatal form features the onset of hypotonia and lethargy at birth, rapidly progressing to coma and death. The infantile form features developmental delay, DYSKINESIAS, hypotonia, spasticity, blindness, and megalencephaly. The juvenile form is characterized by ATAXIA; OPTIC ATROPHY; and DEMENTIA. (From Adams et al., Principles of Neurology, 6th ed, p944; Am J Med Genet 1988 Feb;29(2):463-71)
| Excerpt | Relevance | Reference |
|---|---|---|
| "So far ASPA deficiency and elevated NAA have been ascribed with the CD." | 1.32 | Expression of glutamate transporter, GABRA6, serine proteinase inhibitor 2 and low levels of glutamate and GABA in the brain of knock-out mouse for Canavan disease. ( Campbell, GA; Ezell, EL; Matalon, R; Michals-Matalon, K; Quast, MJ; Rady, PL; Rassin, DK; Surendran, S; Szucs, S; Tyring, SK; Wei, J, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Surendran, S | 2 |
| Rady, PL | 1 |
| Michals-Matalon, K | 2 |
| Quast, MJ | 1 |
| Rassin, DK | 1 |
| Campbell, GA | 1 |
| Ezell, EL | 1 |
| Wei, J | 1 |
| Tyring, SK | 2 |
| Szucs, S | 1 |
| Matalon, R | 2 |
1 review available for gamma-aminobutyric acid and Canavan Disease
| Article | Year |
|---|---|
Canavan disease: studies on the knockout mouse.
Topics: Amidohydrolases; Animals; Canavan Disease; Dipeptides; gamma-Aminobutyric Acid; Gene Targeting; Gene | 2006 |
1 other study available for gamma-aminobutyric acid and Canavan Disease
| Article | Year |
|---|---|
Expression of glutamate transporter, GABRA6, serine proteinase inhibitor 2 and low levels of glutamate and GABA in the brain of knock-out mouse for Canavan disease.
Topics: Amino Acid Transport System X-AG; Analysis of Variance; Animals; Azo Compounds; Brain Chemistry; Can | 2003 |