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gamma-aminobutyric acid and Canavan Disease

gamma-aminobutyric acid has been researched along with Canavan Disease in 2 studies

gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.

Canavan Disease: A rare neurodegenerative condition of infancy or childhood characterized by white matter vacuolization and demeylination that gives rise to a spongy appearance. Aspartoacylase deficiency leads to an accumulation of N-acetylaspartate in astrocytes. Inheritance may be autosomal recessive or the illness may occur sporadically. This illness occurs more frequently in individuals of Ashkenazic Jewish descent. The neonatal form features the onset of hypotonia and lethargy at birth, rapidly progressing to coma and death. The infantile form features developmental delay, DYSKINESIAS, hypotonia, spasticity, blindness, and megalencephaly. The juvenile form is characterized by ATAXIA; OPTIC ATROPHY; and DEMENTIA. (From Adams et al., Principles of Neurology, 6th ed, p944; Am J Med Genet 1988 Feb;29(2):463-71)

Research Excerpts

ExcerptRelevanceReference
"So far ASPA deficiency and elevated NAA have been ascribed with the CD."1.32Expression of glutamate transporter, GABRA6, serine proteinase inhibitor 2 and low levels of glutamate and GABA in the brain of knock-out mouse for Canavan disease. ( Campbell, GA; Ezell, EL; Matalon, R; Michals-Matalon, K; Quast, MJ; Rady, PL; Rassin, DK; Surendran, S; Szucs, S; Tyring, SK; Wei, J, 2003)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Surendran, S2
Rady, PL1
Michals-Matalon, K2
Quast, MJ1
Rassin, DK1
Campbell, GA1
Ezell, EL1
Wei, J1
Tyring, SK2
Szucs, S1
Matalon, R2

Reviews

1 review available for gamma-aminobutyric acid and Canavan Disease

ArticleYear
Canavan disease: studies on the knockout mouse.
    Advances in experimental medicine and biology, 2006, Volume: 576

    Topics: Amidohydrolases; Animals; Canavan Disease; Dipeptides; gamma-Aminobutyric Acid; Gene Targeting; Gene

2006

Other Studies

1 other study available for gamma-aminobutyric acid and Canavan Disease

ArticleYear
Expression of glutamate transporter, GABRA6, serine proteinase inhibitor 2 and low levels of glutamate and GABA in the brain of knock-out mouse for Canavan disease.
    Brain research bulletin, 2003, Aug-30, Volume: 61, Issue:4

    Topics: Amino Acid Transport System X-AG; Analysis of Variance; Animals; Azo Compounds; Brain Chemistry; Can

2003