gamma-aminobutyric acid has been researched along with Burns in 13 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Burns: Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This randomised, double-blind, placebo-controlled trial assessed the efficacy and tolerability of pregabalin to alleviate the neuropathic component of moderate to severe burn pain." | 9.15 | Pregabalin in severe burn injury pain: a double-blind, randomised placebo-controlled trial. ( Cabot, PJ; Cramond, T; Doecke, J; Gray, P; Kirby, J; Smith, MT; Williams, B, 2011) |
| "Compared with that before treatment, the itching degree of patients with light, moderate, and severe itching in placebo group was not relieved after treatment; the itching degree of patients with moderate or severe itching in cetirizine group was alleviated after treatment, but not in patients with light itching; itching degree of all patients in gabapentin group was significantly relieved after treatment." | 7.81 | [Clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn]. ( Bing, Z; Qiang, W; Wei, L; Zheng, L, 2015) |
| "For patients with deep partial-thickness burn, gabapentin can effectively alleviate scar itching after wound healing with safety." | 7.81 | [Clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn]. ( Bing, Z; Qiang, W; Wei, L; Zheng, L, 2015) |
| "To study the clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn." | 7.81 | [Clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn]. ( Bing, Z; Qiang, W; Wei, L; Zheng, L, 2015) |
| "During treatment and post-treatment phases, patients receiving Gp had cumulative morphine consumption and a mean daily pain score significantly lower than controls." | 7.74 | Effects of gabapentin on morphine consumption and pain in severely burned patients. ( Cuignet, O; Pirson, J; Soudon, O; Zizi, M, 2007) |
| "We describe the use of gabapentin for the treatment of itching in wound healing in 35 children." | 7.72 | Gabapentin for the treatment of itching produced by burns and wound healing in children: a pilot study. ( Mendham, JE, 2004) |
| " Drug dosage was determined by initial VAS (visual analog scale) scores." | 6.78 | A four arm, double blind, randomized and placebo controlled study of pregabalin in the management of post-burn pruritus. ( Ahuja, RB; Gupta, GK, 2013) |
| "Gabapentin is an antiepileptic drug which has been successfully used to manage neuropathic pain, and is reporting to be successful in management of all forms of itch." | 6.76 | A comparative analysis of cetirizine, gabapentin and their combination in the relief of post-burn pruritus. ( Ahuja, RB; Gupta, G; Gupta, R; Shrivastava, P, 2011) |
| "Post-burn pruritis is a very distressing symptom having a reported incidence between 80 and 100%." | 6.76 | A comparative analysis of cetirizine, gabapentin and their combination in the relief of post-burn pruritus. ( Ahuja, RB; Gupta, G; Gupta, R; Shrivastava, P, 2011) |
| "Compared with that before treatment, the itching degree of patients with light, moderate, and severe itching in placebo group was not relieved after treatment; the itching degree of patients with moderate or severe itching in cetirizine group was alleviated after treatment, but not in patients with light itching; itching degree of all patients in gabapentin group was significantly relieved after treatment." | 5.42 | [Clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn]. ( Bing, Z; Qiang, W; Wei, L; Zheng, L, 2015) |
| "Gabapentin has established efficacy in the reduction of burn-induced hyperalgesia and allodynia in animal and human experimental burn models." | 5.35 | Successful use of gabapentin in acute pain management following burn injury: a case series. ( Cramond, T; Gray, P; Williams, B, 2008) |
| "Gabapentin (Gp) is an antihyperalgesic drug that selectively affects central sensitization." | 5.34 | Effects of gabapentin on morphine consumption and pain in severely burned patients. ( Cuignet, O; Pirson, J; Soudon, O; Zizi, M, 2007) |
| "Within 24h of commencing treatment itching had improved significantly in all of the children." | 5.32 | Gabapentin for the treatment of itching produced by burns and wound healing in children: a pilot study. ( Mendham, JE, 2004) |
| "This randomised, double-blind, placebo-controlled trial assessed the efficacy and tolerability of pregabalin to alleviate the neuropathic component of moderate to severe burn pain." | 5.15 | Pregabalin in severe burn injury pain: a double-blind, randomised placebo-controlled trial. ( Cabot, PJ; Cramond, T; Doecke, J; Gray, P; Kirby, J; Smith, MT; Williams, B, 2011) |
| "Compared with that before treatment, the itching degree of patients with light, moderate, and severe itching in placebo group was not relieved after treatment; the itching degree of patients with moderate or severe itching in cetirizine group was alleviated after treatment, but not in patients with light itching; itching degree of all patients in gabapentin group was significantly relieved after treatment." | 3.81 | [Clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn]. ( Bing, Z; Qiang, W; Wei, L; Zheng, L, 2015) |
| "For patients with deep partial-thickness burn, gabapentin can effectively alleviate scar itching after wound healing with safety." | 3.81 | [Clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn]. ( Bing, Z; Qiang, W; Wei, L; Zheng, L, 2015) |
| "To study the clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn." | 3.81 | [Clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn]. ( Bing, Z; Qiang, W; Wei, L; Zheng, L, 2015) |
| "During treatment and post-treatment phases, patients receiving Gp had cumulative morphine consumption and a mean daily pain score significantly lower than controls." | 3.74 | Effects of gabapentin on morphine consumption and pain in severely burned patients. ( Cuignet, O; Pirson, J; Soudon, O; Zizi, M, 2007) |
| "We describe the use of gabapentin for the treatment of itching in wound healing in 35 children." | 3.72 | Gabapentin for the treatment of itching produced by burns and wound healing in children: a pilot study. ( Mendham, JE, 2004) |
| " Drug dosage was determined by initial VAS (visual analog scale) scores." | 2.78 | A four arm, double blind, randomized and placebo controlled study of pregabalin in the management of post-burn pruritus. ( Ahuja, RB; Gupta, GK, 2013) |
| "Gabapentin is an antiepileptic drug which has been successfully used to manage neuropathic pain, and is reporting to be successful in management of all forms of itch." | 2.76 | A comparative analysis of cetirizine, gabapentin and their combination in the relief of post-burn pruritus. ( Ahuja, RB; Gupta, G; Gupta, R; Shrivastava, P, 2011) |
| "Post-burn pruritis is a very distressing symptom having a reported incidence between 80 and 100%." | 2.76 | A comparative analysis of cetirizine, gabapentin and their combination in the relief of post-burn pruritus. ( Ahuja, RB; Gupta, G; Gupta, R; Shrivastava, P, 2011) |
| "Post burn pruritus is a well recognised symptom in almost all burn patients." | 2.48 | Post burn pruritus--a review of current treatment options. ( Gupta, AK; Lamba, S; Paul, MK; Prabha, R; Rao, AL; Zachariah, JR, 2012) |
| "Compared with that before treatment, the itching degree of patients with light, moderate, and severe itching in placebo group was not relieved after treatment; the itching degree of patients with moderate or severe itching in cetirizine group was alleviated after treatment, but not in patients with light itching; itching degree of all patients in gabapentin group was significantly relieved after treatment." | 1.42 | [Clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn]. ( Bing, Z; Qiang, W; Wei, L; Zheng, L, 2015) |
| " Time to achieve effective dosing is relatively quick and there is a range of dosing available." | 1.36 | Treatment of post-burn neuropathic pain: evaluation of pregablin. ( Turner, L; Wong, L, 2010) |
| "Gabapentin has established efficacy in the reduction of burn-induced hyperalgesia and allodynia in animal and human experimental burn models." | 1.35 | Successful use of gabapentin in acute pain management following burn injury: a case series. ( Cramond, T; Gray, P; Williams, B, 2008) |
| "Gabapentin (Gp) is an antihyperalgesic drug that selectively affects central sensitization." | 1.34 | Effects of gabapentin on morphine consumption and pain in severely burned patients. ( Cuignet, O; Pirson, J; Soudon, O; Zizi, M, 2007) |
| "Within 24h of commencing treatment itching had improved significantly in all of the children." | 1.32 | Gabapentin for the treatment of itching produced by burns and wound healing in children: a pilot study. ( Mendham, JE, 2004) |
| "Gabapentin is an anticonvulsant that may represent a novel class of drugs, which has novel spinal antihyperalgesic activity." | 1.30 | The effect of intrathecal gabapentin and 3-isobutyl gamma-aminobutyric acid on the hyperalgesia observed after thermal injury in the rat. ( Jun, JH; Yaksh, TL, 1998) |
| "Secondary hyperalgesia exhibited a tendency toward recovery over time." | 1.30 | Systemic gabapentin and S(+)-3-isobutyl-gamma-aminobutyric acid block secondary hyperalgesia. ( Jones, DL; Sorkin, LS, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 7 (53.85) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Polychronopoulou, E | 1 |
| Kuo, YF | 1 |
| Wilkes, D | 1 |
| Raji, MA | 1 |
| Zheng, L | 1 |
| Bing, Z | 1 |
| Wei, L | 1 |
| Qiang, W | 1 |
| Wong, L | 1 |
| Turner, L | 1 |
| Ahuja, RB | 2 |
| Gupta, R | 1 |
| Gupta, G | 1 |
| Shrivastava, P | 1 |
| Gray, P | 2 |
| Kirby, J | 1 |
| Smith, MT | 1 |
| Cabot, PJ | 1 |
| Williams, B | 2 |
| Doecke, J | 1 |
| Cramond, T | 2 |
| Zachariah, JR | 1 |
| Rao, AL | 1 |
| Prabha, R | 1 |
| Gupta, AK | 1 |
| Paul, MK | 1 |
| Lamba, S | 1 |
| Anand, S | 1 |
| Gupta, GK | 1 |
| Mendham, JE | 1 |
| Cuignet, O | 1 |
| Pirson, J | 1 |
| Soudon, O | 1 |
| Zizi, M | 1 |
| Jun, JH | 1 |
| Yaksh, TL | 1 |
| Jones, DL | 1 |
| Sorkin, LS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Preoperative Pregabalin on Pain Intensity and Interleukin-6 Levels in Living Donor Kidney[NCT01529190] | Phase 2 | 40 participants (Actual) | Interventional | 2011-03-31 | Completed | ||
| The Effect of Neurontin on Pain Management in the Acutely Burned Patient[NCT01265056] | 53 participants (Actual) | Interventional | 2010-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The sickness inventory profile (SIP) is a behaviorally based measure of health status. Scores range from 0-68 with higher numbers indicating worse outcomes. The study report total SIP score. The higher the score the worse the function. (NCT01265056)
Timeframe: First Clinic Follow Up After Discharge
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | 34.9 |
| Gabapentin | 36.0 |
(NCT01265056)
Timeframe: From time of enrollment to 2 weeks after being discharged
| Intervention | morphine equivalents (Mean) |
|---|---|
| Placebo | 7.0 |
| Gabapentin | 6.7 |
The Brief Symptom Inventory 18 (BSI 18) is designed with reliability in mind. The BSI 18 assessment gathers patient-reported data to help measure psychological distress and psychiatric disorders in medical and community populations. As the latest in an integrated series of test instruments that include the SCL-90-R®, BSI® (53 questions), and DPRS® instruments, the BSI 18 test offers a more effective, easy-to-administer tool to help support clinical decision-making and monitor progress throughout treatment. BSI-18 measures three dimensions with 6 questions a piece (somatization , depression , anxiety) and overall psychological distress scores (Global severity index, GSI). Each of the 18 items range from a score of 0-4; total score ranges from 0-72 with higher scores indicating worse function. The GSI score is calculated as the mean of the three subscales. The study reported the GSI score. Higher score is worse. (NCT01265056)
Timeframe: First Clinic Follow Up After Discharge
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | 9 |
| Gabapentin | 7.3 |
2 reviews available for gamma-aminobutyric acid and Burns
| Article | Year |
|---|---|
Post burn pruritus--a review of current treatment options.
Topics: Amines; Analgesics; Burns; Cyclohexanecarboxylic Acids; Emollients; Gabapentin; gamma-Aminobutyric A | 2012 |
Gabapentin for pruritus in palliative care.
Topics: Amines; Analgesics, Opioid; Burns; Cholestasis; Cyclohexanecarboxylic Acids; Dermatologic Agents; Ga | 2013 |
3 trials available for gamma-aminobutyric acid and Burns
| Article | Year |
|---|---|
A comparative analysis of cetirizine, gabapentin and their combination in the relief of post-burn pruritus.
Topics: Adolescent; Adult; Aged; Amines; Analgesics; Burns; Cetirizine; Child; Cyclohexanecarboxylic Acids; | 2011 |
Pregabalin in severe burn injury pain: a double-blind, randomised placebo-controlled trial.
Topics: Adolescent; Adult; Aged; Analgesics; Analgesics, Opioid; Burns; Dose-Response Relationship, Drug; Do | 2011 |
A four arm, double blind, randomized and placebo controlled study of pregabalin in the management of post-burn pruritus.
Topics: Adult; Analgesics; Anti-Allergic Agents; Burns; Cetirizine; Coconut Oil; Double-Blind Method; Female | 2013 |
8 other studies available for gamma-aminobutyric acid and Burns
| Article | Year |
|---|---|
Prescribing of Gabapentinoids with or without opioids after burn injury in the US, 2012-2018.
Topics: Adult; Analgesics, Opioid; Burns; Cohort Studies; gamma-Aminobutyric Acid; Humans; Pain; Practice Pa | 2022 |
[Clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn].
Topics: Amines; Analgesics; Ascorbic Acid; Burns; Cetirizine; Cicatrix; Cyclohexanecarboxylic Acids; Gabapen | 2015 |
Treatment of post-burn neuropathic pain: evaluation of pregablin.
Topics: Analgesics; Burns; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Humans; Male; | 2010 |
Gabapentin for the treatment of itching produced by burns and wound healing in children: a pilot study.
Topics: Adolescent; Amines; Antipruritics; Burns; Child; Child Behavior Disorders; Child, Preschool; Cyclohe | 2004 |
Effects of gabapentin on morphine consumption and pain in severely burned patients.
Topics: Administration, Oral; Amines; Analgesics; Burns; Case-Control Studies; Cyclohexanecarboxylic Acids; | 2007 |
Successful use of gabapentin in acute pain management following burn injury: a case series.
Topics: Adult; Amines; Analgesics; Burns; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyri | 2008 |
The effect of intrathecal gabapentin and 3-isobutyl gamma-aminobutyric acid on the hyperalgesia observed after thermal injury in the rat.
Topics: Acetates; Amines; Animals; Anticonvulsants; Burns; Cyclohexanecarboxylic Acids; Dose-Response Relati | 1998 |
Systemic gabapentin and S(+)-3-isobutyl-gamma-aminobutyric acid block secondary hyperalgesia.
Topics: Acetates; Amines; Animals; Anticonvulsants; Burns; Cyclohexanecarboxylic Acids; Dose-Response Relati | 1998 |