gamma-aminobutyric acid and Brain Neoplasms studies

gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.

Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.

Research Excerpts

Excerpt	Relevance	Reference
" Approximately 30-40% of brain tumors patients who present with status epilepticus (SE) will not respond to typical therapy consisting of benzodiazepines and phenytoin (PHT), resulting in patients with refractory status epilepticus (RSE)."	7.78	Phenytoin, levetiracetam, and pregabalin in the acute management of refractory status epilepticus in patients with brain tumors. ( Doreswamy, M; Gingrich, KJ; Kolls, BJ; Swisher, CB; Vredenburgh, JJ, 2012)
"An open pilot study to evaluate the effect of pregabalin (PGB) as add-on therapy on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy (BTRE)."	7.78	Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study. ( Carapella, CM; Dinapoli, L; Fabi, A; Maschio, M; Pace, A; Pompili, A; Sperati, F; Vidiri, A, 2012)
"Here we describe our experience with pregabalin (PGB); its effectiveness was retrospectively studied in nine consecutive patients with primary brain tumors and seizures."	7.75	Pregabalin in patients with primary brain tumors and seizures: a preliminary observation. ( Novy, J; Rossetti, AO; Stupp, R, 2009)
"The properties of [3H]-gamma-aminobutyric acid [( 3H]GABA) binding were studied in biopsied specimens from normal human brain and from 18 cases of human brain gliomas, made up of 6 astrocytomas, 6 glioblastomas, 3 oligodendrogliomas, and 3 medulloblastomas."	7.67	Characterization of the gamma-aminobutyric acid receptor system in human brain gliomas. ( Canal, N; Ferrarese, C; Frattola, L; Gaini, SM; Galluso, R; Piolti, R; Trabucchi, M, 1985)
"Approximately 30-40% of brain tumors patients who present with status epilepticus (SE) will not respond to typical therapy consisting of benzodiazepines and phenytoin (PHT), resulting in patients with refractory status epilepticus (RSE)."	5.38	Phenytoin, levetiracetam, and pregabalin in the acute management of refractory status epilepticus in patients with brain tumors. ( Doreswamy, M; Gingrich, KJ; Kolls, BJ; Swisher, CB; Vredenburgh, JJ, 2012)
" Mean PGB dosage was 279 mg/day."	5.38	Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study. ( Carapella, CM; Dinapoli, L; Fabi, A; Maschio, M; Pace, A; Pompili, A; Sperati, F; Vidiri, A, 2012)
" Daily median dosage was 300 mg."	5.35	Pregabalin in patients with primary brain tumors and seizures: a preliminary observation. ( Novy, J; Rossetti, AO; Stupp, R, 2009)
"Patients with brain tumors and seizures should be treated with non-enzyme-inducing antiepileptic drugs (AED)."	5.35	Pregabalin in patients with primary brain tumors and seizures: a preliminary observation. ( Novy, J; Rossetti, AO; Stupp, R, 2009)
"All subjects experienced at least a 50% seizure reduction, six were seizure-free."	5.35	Pregabalin in patients with primary brain tumors and seizures: a preliminary observation. ( Novy, J; Rossetti, AO; Stupp, R, 2009)
"Seizures associated with intracranial neoplasms are occasionally refractory to conventional anti-epileptic drugs."	5.29	Add-on gabapentin for refractory seizures in patients with brain tumours. ( Perry, JR; Sawka, C, 1996)
"Complete resolution of seizures occurred in 8/14 patients."	5.29	Add-on gabapentin for refractory seizures in patients with brain tumours. ( Perry, JR; Sawka, C, 1996)
"Patients undergoing craniotomy received either placebo (group D) or gabapentin (600 mg) (group GD) premedication orally, 2 hours before induction of anesthesia."	5.17	The effect of gabapentin premedication on postoperative nausea, vomiting, and pain in patients on preoperative dexamethasone undergoing craniotomy for intracranial tumors. ( Misra, S; Parthasarathi, G; Vilanilam, GC, 2013)
"An open pilot study to evaluate the effect of pregabalin (PGB) as add-on therapy on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy (BTRE)."	3.78	Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study. ( Carapella, CM; Dinapoli, L; Fabi, A; Maschio, M; Pace, A; Pompili, A; Sperati, F; Vidiri, A, 2012)
" Approximately 30-40% of brain tumors patients who present with status epilepticus (SE) will not respond to typical therapy consisting of benzodiazepines and phenytoin (PHT), resulting in patients with refractory status epilepticus (RSE)."	3.78	Phenytoin, levetiracetam, and pregabalin in the acute management of refractory status epilepticus in patients with brain tumors. ( Doreswamy, M; Gingrich, KJ; Kolls, BJ; Swisher, CB; Vredenburgh, JJ, 2012)
"Here we describe our experience with pregabalin (PGB); its effectiveness was retrospectively studied in nine consecutive patients with primary brain tumors and seizures."	3.75	Pregabalin in patients with primary brain tumors and seizures: a preliminary observation. ( Novy, J; Rossetti, AO; Stupp, R, 2009)
"H4 human neuroglioma cells stably transfected to express human full-length wild-type amyloid precursor protein (APP) were exposed to 2% isoflurane for 6 h."	3.73	The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels. ( Alfille, P; Crosby, G; Culley, DJ; Dong, Y; Maeda, U; Tanzi, RE; Xie, Z, 2006)
"Two percent isoflurane caused apoptosis, altered processing of APP, and increased production of Abeta in H4 human neuroglioma cell lines."	3.73	The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels. ( Alfille, P; Crosby, G; Culley, DJ; Dong, Y; Maeda, U; Tanzi, RE; Xie, Z, 2006)
"A clinically relevant concentration of isoflurane induces apoptosis, alters APP processing, and increases Abeta production in a human neuroglioma cell line."	3.73	The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels. ( Alfille, P; Crosby, G; Culley, DJ; Dong, Y; Maeda, U; Tanzi, RE; Xie, Z, 2006)
"The properties of [3H]-gamma-aminobutyric acid [( 3H]GABA) binding were studied in biopsied specimens from normal human brain and from 18 cases of human brain gliomas, made up of 6 astrocytomas, 6 glioblastomas, 3 oligodendrogliomas, and 3 medulloblastomas."	3.67	Characterization of the gamma-aminobutyric acid receptor system in human brain gliomas. ( Canal, N; Ferrarese, C; Frattola, L; Gaini, SM; Galluso, R; Piolti, R; Trabucchi, M, 1985)
"Recent studies suggest that seizures at the onset of GBM could be a possible favorable independent prognostic factor in patients."	2.82	Epileptogenesis and Tumorigenesis in Glioblastoma: Which Relationship? ( Biagini, G; Cavallieri, F; Cozzi, S; Giaccherini, L; Pisanello, A; Rizzi, R; Rossi, J; Russo, M; Valzania, F, 2022)
"In patients with brain tumors, the choice of antiepileptic medication is guided by tolerability and pharmacokinetic interactions."	2.79	Levetiracetam and pregabalin for antiepileptic monotherapy in patients with primary brain tumors. A phase II randomized study. ( Jeckelmann, S; Novy, J; Rossetti, AO; Roth, P; Stupp, R; Weller, M, 2014)
"A dosage of 600 mg of gabapentin plus 4 mg of dexamethasone significantly reduced the 24-hour incidence of nausea and PONV."	2.78	The effect of gabapentin premedication on postoperative nausea, vomiting, and pain in patients on preoperative dexamethasone undergoing craniotomy for intracranial tumors. ( Misra, S; Parthasarathi, G; Vilanilam, GC, 2013)
"Therefore, the optimal seizure management by antiepileptic drugs (AEDs) in this patient category is essentially unsure."	2.43	Optimal seizure management in brain tumor patients. ( van Breemen, MS; Vecht, CJ, 2005)
"Bidirectional interplay of breast cancer cells and native brain cells in metastasis is poorly understood and rarely studied."	1.40	Human breast cancer metastases to the brain display GABAergic properties in the neural niche. ( Choy, C; Hambrecht, AC; Jandial, R; Kowolik, CM; Li, H; Neman, J; Roberts, E; Termini, J; Vaidehi, N; Wilczynski, S, 2014)
"Brain gliomas are highly epileptogenic."	1.40	Cortical GABAergic excitation contributes to epileptic activities around human glioma. ( Baulac, M; Bielle, F; Capelle, L; Chazal, G; Cresto, N; Devaux, B; Duyckaerts, C; Huberfeld, G; Kourdougli, N; Le Van Quyen, M; Miles, R; Pallud, J; Pellegrino, C; Rivera, C; Varlet, P, 2014)
"Approximately 30-40% of brain tumors patients who present with status epilepticus (SE) will not respond to typical therapy consisting of benzodiazepines and phenytoin (PHT), resulting in patients with refractory status epilepticus (RSE)."	1.38	Phenytoin, levetiracetam, and pregabalin in the acute management of refractory status epilepticus in patients with brain tumors. ( Doreswamy, M; Gingrich, KJ; Kolls, BJ; Swisher, CB; Vredenburgh, JJ, 2012)
"In the renal cell carcinoma, in contrast with GBM, (13) C multiplets of γ-aminobutyric acid (GABA) differed from its precursor glutamate, suggesting that GABA did not derive from a common glutamate precursor pool."	1.38	Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors. ( Bachoo, RM; Cho, SK; Choi, C; Deberardinis, RJ; Good, LB; Hatanpaa, KJ; Jindal, A; Kapur, P; Maher, EA; Malloy, CR; Marin-Valencia, I; Mashimo, T; Mickey, B; Pascual, JM; Raisanen, J; Rakheja, D; Sun, X; Takahashi, M; Togao, O; Vemireddy, V, 2012)
" Mean PGB dosage was 279 mg/day."	1.38	Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study. ( Carapella, CM; Dinapoli, L; Fabi, A; Maschio, M; Pace, A; Pompili, A; Sperati, F; Vidiri, A, 2012)
" Daily median dosage was 300 mg."	1.35	Pregabalin in patients with primary brain tumors and seizures: a preliminary observation. ( Novy, J; Rossetti, AO; Stupp, R, 2009)
"Patients with brain tumors and seizures should be treated with non-enzyme-inducing antiepileptic drugs (AED)."	1.35	Pregabalin in patients with primary brain tumors and seizures: a preliminary observation. ( Novy, J; Rossetti, AO; Stupp, R, 2009)
"All subjects experienced at least a 50% seizure reduction, six were seizure-free."	1.35	Pregabalin in patients with primary brain tumors and seizures: a preliminary observation. ( Novy, J; Rossetti, AO; Stupp, R, 2009)
"Seizures associated with intracranial neoplasms are occasionally refractory to conventional anti-epileptic drugs."	1.29	Add-on gabapentin for refractory seizures in patients with brain tumours. ( Perry, JR; Sawka, C, 1996)
"Complete resolution of seizures occurred in 8/14 patients."	1.29	Add-on gabapentin for refractory seizures in patients with brain tumours. ( Perry, JR; Sawka, C, 1996)
"In 49 patients with various neurological disorders plasma and CSF gamma-aminobutyric acid (GABA) concentrations were determined by radioreceptor assay."	1.26	Plasma and cerebrospinal fluid gamma-aminobutyric acid in neurological disorders. ( Löscher, W; Schmidt, D, 1982)

Research

Studies (58)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

"VAS Score 1: How Much Pain do You Feel in Your Operative Site When Resting?"

Timeframe	Studies, this research(%)	All Research%
pre-1990	12 (20.69)	18.7374
1990's	5 (8.62)	18.2507
2000's	11 (18.97)	29.6817
2010's	24 (41.38)	24.3611
2020's	6 (10.34)	2.80

Authors	Studies
Deshpande, K	1
Martirosian, V	1
Nakamura, BN	1
Iyer, M	1
Julian, A	1
Eisenbarth, R	1
Shao, L	1
Attenello, F	1
Neman, J	2
Rossi, J	1
Cavallieri, F	1
Biagini, G	1
Rizzi, R	1
Russo, M	1
Cozzi, S	1
Giaccherini, L	1
Pisanello, A	1
Valzania, F	1
Jiang, H	3
Sun, Z	3
Li, F	3
Chen, Q	3
Palma, A	1
Grande, S	1
Ricci-Vitiani, L	1
Luciani, AM	1
Buccarelli, M	1
Biffoni, M	1
Dini, V	1
Cirrone, GAP	1
Ciocca, M	1
Guidoni, L	1
Pallini, R	1
Viti, V	1
Rosi, A	1
Gong, T	1
Zhang, X	1
Wei, X	1
Yuan, S	1
Saleh, MG	1
Song, Y	1
Edden, RA	1
Wang, G	1
Okawa, T	1
Hara, K	1
Goto, M	1
Kikuchi, M	1
Kogane, M	1
Hatakeyama, H	1
Tanaka, H	1
Shirane, D	1
Akita, H	1
Hisaka, A	1
Sato, H	1
Corona-Ramos, JN	1
Déciga-Campos, M	1
Romero-Piña, M	1
Medina, LA	1
Martínez-Racine, I	1
Jaramillo-Morales, OA	1
García-López, P	1
López-Muñoz, FJ	1
Zawaski, JA	1
Sabek, OM	1
Voicu, H	1
Eastwood Leung, HC	1
Gaber, MW	1
Lai, M	1
Vassallo, I	1
Lanz, B	1
Poitry-Yamate, C	1
Hamou, MF	1
Cudalbu, C	1
Gruetter, R	1
Hegi, ME	1
Mari, Z	1
Rosenthal, LS	1
Darwin, KC	1
Hallett, M	1
Jinnah, HA	1
Choi, C	2
Ganji, S	1
Hulsey, K	1
Madan, A	1
Kovacs, Z	1
Dimitrov, I	1
Zhang, S	1
Pichumani, K	1
Mendelsohn, D	1
Mickey, B	2
Malloy, C	1
Bachoo, R	1
Deberardinis, R	1
Maher, E	1
Misra, S	2
Parthasarathi, G	1
Vilanilam, GC	1
Rossetti, AO	2
Jeckelmann, S	1
Novy, J	2
Roth, P	1
Weller, M	1
Stupp, R	2
Termini, J	1
Wilczynski, S	1
Vaidehi, N	1
Choy, C	1
Kowolik, CM	1
Li, H	1
Hambrecht, AC	1
Roberts, E	1
Jandial, R	1
Pallud, J	2
Le Van Quyen, M	1
Bielle, F	1
Pellegrino, C	1
Varlet, P	2
Cresto, N	1
Baulac, M	1
Duyckaerts, C	1
Kourdougli, N	1
Chazal, G	1
Devaux, B	2
Rivera, C	1
Miles, R	1
Capelle, L	1
Huberfeld, G	1
Campbell, SL	1
Robel, S	1
Cuddapah, VA	1
Robert, S	1
Buckingham, SC	1
Kahle, KT	1
Sontheimer, H	1
Di Angelantonio, S	1
Murana, E	1
Cocco, S	1
Scala, F	1
Bertollini, C	1
Molinari, MG	1
Lauro, C	2
Bregestovski, P	1
Limatola, C	2
Ragozzino, D	1
Nelp, TB	1
McGovern, RA	1
McKhann, GM	1
Hackett, CS	1
Quigley, DA	1
Wong, RA	1
Chen, J	1
Cheng, C	1
Song, YK	1
Wei, JS	1
Pawlikowska, L	1
Bao, Y	1
Goldenberg, DD	1
Nguyen, K	1
Gustafson, WC	1
Rallapalli, SK	1
Cho, YJ	1
Cook, JM	1
Kozlov, S	1
Mao, JH	1
Van Dyke, T	1
Kwok, PY	1
Khan, J	1
Balmain, A	1
Fan, Q	1
Weiss, WA	1
Van Swearingen, AE	1
Siegel, MB	1
Anders, CK	1
MacKenzie, G	1
O'Toole, KK	1
Moss, SJ	1
Maguire, J	1
Yan, G	1
Zhang, T	2
Dai, Z	1
Yi, M	1
Jia, Y	1
Nie, T	1
Zhang, H	1
Xiao, G	1
Wu, R	1
El-Habr, EA	1
Dubois, LG	1
Burel-Vandenbos, F	1
Bogeas, A	1
Lipecka, J	1
Turchi, L	1
Lejeune, FX	1
Coehlo, PL	1
Yamaki, T	1
Wittmann, BM	1
Fareh, M	1
Mahfoudhi, E	1
Janin, M	1
Narayanan, A	1
Morvan-Dubois, G	1
Schmitt, C	1
Verreault, M	1
Oliver, L	1
Sharif, A	1
Puget, S	1
Korkolopoulou, P	1
Ottolenghi, C	1
Plo, I	1
Moura-Neto, V	1
Virolle, T	1
Chneiweiss, H	1
Junier, MP	1
Roach, JD	1
Aguinaldo, GT	1
Jonnalagadda, K	1
Hughes, FM	1
Spangelo, BL	1
Striano, S	1
Striano, P	1
Coppola, A	1
Romanelli, P	1
Crespo Pérez, L	1
Moreira Vicente, V	1
Cano Ruiz, A	1
Gobernado Serrano, JM	1
Cobo Ibañez, N	1
Milicua Salamero, JM	1
Koshy, T	1
Unnikrishnan, KP	1
Suneel, PR	1
Chatterjee, N	1
Wang, YY	1
Liu, SC	1
Yang, Z	1
Conti, L	1
Palma, E	1
Roseti, C	1
Cipriani, R	1
de Groot, M	1
Aronica, E	3
Swisher, CB	1
Doreswamy, M	1
Gingrich, KJ	1
Vredenburgh, JJ	1
Kolls, BJ	1
Marin-Valencia, I	1
Cho, SK	1
Rakheja, D	1
Hatanpaa, KJ	1
Kapur, P	1
Mashimo, T	1
Jindal, A	1
Vemireddy, V	1
Good, LB	1
Raisanen, J	1
Sun, X	1
Takahashi, M	1
Togao, O	1
Pascual, JM	1
Deberardinis, RJ	1
Maher, EA	1
Malloy, CR	1
Bachoo, RM	1
Smits, A	1
Jin, Z	1
Elsir, T	1
Pedder, H	1
Nistér, M	1
Alafuzoff, I	1
Dimberg, A	1
Edqvist, PH	1
Pontén, F	1
Birnir, B	1
Maschio, M	1
Dinapoli, L	1
Sperati, F	1
Pace, A	1
Fabi, A	1
Vidiri, A	1
Pompili, A	1
Carapella, CM	1
Opstad, KS	1
Provencher, SW	1
Bell, BA	1
Griffiths, JR	1
Howe, FA	1
WALLEMANN, M	1
DEVENYI, T	1
Porzio, G	1
Aielli, F	1
Narducci, F	1
Varrassi, G	1
Ricevuto, E	1
Ficorella, C	1
Marchetti, P	1
van Breemen, MS	1
Vecht, CJ	1
Xie, Z	1
Dong, Y	1
Maeda, U	1
Alfille, P	1
Culley, DJ	1
Crosby, G	1
Tanzi, RE	1
Hu, J	1
Yang, S	1
Xuan, Y	1
Jiang, Q	1
Yang, Y	1
Haacke, EM	1
Scarabino, T	1
Giannatempo, GM	1
Popolizio, T	1
Tosetti, M	1
d'Alesio, V	1
Esposito, F	1
Di Salle, F	1
Di Costanzo, A	1
Bertolino, A	1
Maggialetti, A	1
Salvolini, U	1
Boer, K	1
Becker, A	1
Redeker, S	1
Spliet, WG	1
van Rijen, PC	2
Wittink, F	1
Breit, T	1
Wadman, WJ	1
Lopes da Silva, FH	1
Troost, D	1
Gorter, JA	1
Zlobina, GP	2
Kondakova, LI	2
Mukhin, AG	2
Schmidt, D	1
Löscher, W	1
von Metzler, A	2
Nitsch, C	2
Perry, JR	1
Sawka, C	1
Arroyo, S	1
Rumiá, J	1
Martínez, I	1
Ribalta, T	1
Bouzier, AK	1
Quesson, B	1
Valeins, H	1
Canioni, P	1
Merle, M	1
Hoogland, G	1
Blomenröhr, M	1
Dijstelbloem, H	1
de Wit, M	1
Spierenburg, HA	1
van Veelen, CW	1
van Huffelen, AC	1
Gispen, WH	1
de Graan, PN	1
Lefauconnier, JM	1
Portemer, C	1
Chatagner, F	1
Haglid, KG	1
Hamberger, A	1
Carlsson, CA	1
Lindgren, S	1
Stavrou, D	1
Sourander, P	1
Haglund, MM	1
Berger, MS	1
Kunkel, DD	1
Franck, JE	1
Ghatan, S	1
Ojemann, GA	1
Palmer, GC	1
Bateman, DE	1
Hardy, JA	1
McDermott, JR	1
Parker, DS	1
Edwardson, JA	1
Frattola, L	1
Ferrarese, C	1
Canal, N	1
Gaini, SM	1
Galluso, R	1
Piolti, R	1
Trabucchi, M	1
Dereux-Mortier, SA	1
Dereux, JF	1
Gallois, P	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Gabapentin Regimens and Their Effects on Opioid Consumption[NCT03334903]	Phase 4	77 participants (Actual)	Interventional	2018-05-15	Completed
Treatment Development of Triheptanoin for Glucose Transporter Type I Deficiency[NCT02021526]	Phase 1/Phase 2	0 participants (Actual)	Interventional	2015-12-31	Withdrawn (stopped due to NIH funding resulted in new clinical trial)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Surgical site pain. Scale 0-10, with 0 best and 10 worst (NCT03334903)
Timeframe: 2-3 months after surgery (at 2nd postoperative appointment)

"VAS Score 2: How Much Pain do You Feel in Your Operative Site When Moving?"

Intervention	score on 10-point scale (Mean)
Standard of Care	2.26
Postoperative Gabapentin Regimen	2.46

Surgical site pain. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

"VAS Score 3: How Well Are You Sleeping?"

Intervention	score on a 10-point scale (Mean)
Standard of Care	3.84
Postoperative Gabapentin Regimen	3.54

Sleep quality. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

"VAS Score 4: How Bad is Your Nausea?"

Intervention	score on a 10-point scale (Mean)
Standard of Care	5.73
Postoperative Gabapentin Regimen	6.38

Nausea. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

"VAS Score 5: How Satisfied Are You With Your Pain Management?"

Intervention	score on a 10-point scale (Mean)
Standard of Care	0.36
Postoperative Gabapentin Regimen	0.17

Satisfaction. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Days Taking Opioids

Intervention	score on a 10-point scale (Mean)
Standard of Care	7.83
Postoperative Gabapentin Regimen	8.48

Number of days until patients are finished consuming opioid medications after discharge. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Opioid Consumption

Intervention	days (Mean)
Standard of Care	14.8
Postoperative Gabapentin Regimen	18.7

Mean opioid consumption, measured in mg of morphine equivalents. (NCT03334903)
Timeframe: 2-3 months following surgery (total amount measured at second postoperative appointment; means assessed afterwards).

Article	Year
Epileptogenesis and Tumorigenesis in Glioblastoma: Which Relationship? Medicina (Kaunas, Lithuania), 2022, Sep-26, Volume: 58, Issue:10 Topics: Aquaporins; Brain Neoplasms; Cell Transformation, Neoplastic; gamma-Aminobutyric Acid; Glioblastoma;	2022
Clinical Reasoning: a 57-year-old man with jaw spasms. Neurology, 2013, Mar-05, Volume: 80, Issue:10 Topics: Adrenergic Uptake Inhibitors; Amines; Anticonvulsants; Brain Neoplasms; Cyclohexanecarboxylic Acids;	2013
The syndrome gelastic seizures-hypothalamic hamartoma: severe, potentially reversible encephalopathy. Epilepsia, 2009, Volume: 50 Suppl 5 Topics: Brain Neoplasms; Cognition Disorders; Epilepsies, Partial; gamma-Aminobutyric Acid; Hamartoma; Hypot	2009
[Anticonvulsant hypersensitivity syndrome: an entity to be remembered]. Gastroenterologia y hepatologia, 2009, Volume: 32, Issue:10 Topics: Adolescent; Amines; Anemia, Hemolytic; Anticonvulsants; Astrocytoma; Brain Neoplasms; Carbamazepine;	2009
Optimal seizure management in brain tumor patients. Current neurology and neuroscience reports, 2005, Volume: 5, Issue:3 Topics: Amines; Anticonvulsants; Antineoplastic Agents; Brain Neoplasms; Cyclohexanecarboxylic Acids; Drug I	2005
Cyclic nucleotides in stroke and related cerebrovascular disorders. Life sciences, 1985, May-27, Volume: 36, Issue:21 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenosine; Adenylyl Cyclas	1985

Article	Year
The effect of gabapentin premedication on postoperative nausea, vomiting, and pain in patients on preoperative dexamethasone undergoing craniotomy for intracranial tumors. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:4 Topics: Adult; Amines; Anesthesia; Anti-Inflammatory Agents; Brain Neoplasms; Craniotomy; Cyclohexanecarboxy	2013
Levetiracetam and pregabalin for antiepileptic monotherapy in patients with primary brain tumors. A phase II randomized study. Neuro-oncology, 2014, Volume: 16, Issue:4 Topics: Anticonvulsants; Brain Neoplasms; Epilepsy; Female; Follow-Up Studies; gamma-Aminobutyric Acid; Huma	2014
Gabapentin premedication decreases the hemodynamic response to skull pin insertion in patients undergoing craniotomy. Journal of neurosurgical anesthesiology, 2011, Volume: 23, Issue:2 Topics: Adolescent; Adult; Amines; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Local; Blood P	2011

Article	Year
Neuronal exposure induces neurotransmitter signaling and synaptic mediators in tumors early in brain metastasis. Neuro-oncology, 2022, 06-01, Volume: 24, Issue:6 Topics: Brain Neoplasms; Breast Neoplasms; Female; gamma-Aminobutyric Acid; Humans; Lung Neoplasms; Neurons;	2022
Prognostic value of γ-aminobutyric acidergic synapse-associated signature for lower-grade gliomas. Frontiers in immunology, 2022, Volume: 13 Topics: Brain Neoplasms; gamma-Aminobutyric Acid; Gene Expression Regulation, Neoplastic; Glioma; Humans; Pr	2022
Prognostic value of γ-aminobutyric acidergic synapse-associated signature for lower-grade gliomas. Frontiers in immunology, 2022, Volume: 13 Topics: Brain Neoplasms; gamma-Aminobutyric Acid; Gene Expression Regulation, Neoplastic; Glioma; Humans; Pr	2022
Prognostic value of γ-aminobutyric acidergic synapse-associated signature for lower-grade gliomas. Frontiers in immunology, 2022, Volume: 13 Topics: Brain Neoplasms; gamma-Aminobutyric Acid; Gene Expression Regulation, Neoplastic; Glioma; Humans; Pr	2022
Prognostic value of γ-aminobutyric acidergic synapse-associated signature for lower-grade gliomas. Frontiers in immunology, 2022, Volume: 13 Topics: Brain Neoplasms; gamma-Aminobutyric Acid; Gene Expression Regulation, Neoplastic; Glioma; Humans; Pr	2022
Prognostic value of γ-aminobutyric acidergic synapse-associated signature for lower-grade gliomas. Frontiers in immunology, 2022, Volume: 13 Topics: Brain Neoplasms; gamma-Aminobutyric Acid; Gene Expression Regulation, Neoplastic; Glioma; Humans; Pr	2022
Prognostic value of γ-aminobutyric acidergic synapse-associated signature for lower-grade gliomas. Frontiers in immunology, 2022, Volume: 13 Topics: Brain Neoplasms; gamma-Aminobutyric Acid; Gene Expression Regulation, Neoplastic; Glioma; Humans; Pr	2022
Prognostic value of γ-aminobutyric acidergic synapse-associated signature for lower-grade gliomas. Frontiers in immunology, 2022, Volume: 13 Topics: Brain Neoplasms; gamma-Aminobutyric Acid; Gene Expression Regulation, Neoplastic; Glioma; Humans; Pr	2022
Prognostic value of γ-aminobutyric acidergic synapse-associated signature for lower-grade gliomas. Frontiers in immunology, 2022, Volume: 13 Topics: Brain Neoplasms; gamma-Aminobutyric Acid; Gene Expression Regulation, Neoplastic; Glioma; Humans; Pr	2022
Prognostic value of γ-aminobutyric acidergic synapse-associated signature for lower-grade gliomas. Frontiers in immunology, 2022, Volume: 13 Topics: Brain Neoplasms; gamma-Aminobutyric Acid; Gene Expression Regulation, Neoplastic; Glioma; Humans; Pr	2022
Different Mechanisms Underlie the Metabolic Response of GBM Stem-Like Cells to Ionizing Radiation: Biological and MRS Studies on Effects of Photons and Carbon Ions. International journal of molecular sciences, 2020, Jul-21, Volume: 21, Issue:14 Topics: Brain Neoplasms; Cell Line, Tumor; G2 Phase Cell Cycle Checkpoints; gamma-Aminobutyric Acid; Gliobla	2020
GSH and GABA decreases in IDH1-mutated low-grade gliomas detected by HERMES spectral editing at 3 T in vivo. Neurochemistry international, 2020, Volume: 141 Topics: Adult; Aged; Body Water; Brain Neoplasms; Electromagnetic Fields; Female; gamma-Aminobutyric Acid; G	2020
Effects on Metabolism in Astrocytes Caused by cGAMP, Which Imitates the Initial Stage of Brain Metastasis. International journal of molecular sciences, 2021, Aug-21, Volume: 22, Issue:16 Topics: Animals; Astrocytes; Brain Neoplasms; gamma-Aminobutyric Acid; Glucose; Neoplasm Metastasis; Nucleot	2021
The Effect of Gabapentin and Tramadol in Cancer Pain Induced by Glioma Cell in Rat Femur. Drug development research, 2017, Volume: 78, Issue:5 Topics: Amines; Analgesics; Animals; Bone Neoplasms; Brain Neoplasms; Cancer Pain; Cell Line, Tumor; Cell Su	2017
Effect of Brain Tumor Presence During Radiation on Tissue Toxicity: Transcriptomic and Metabolic Changes. International journal of radiation oncology, biology, physics, 2017, 11-15, Volume: 99, Issue:4 Topics: Allografts; Animals; Biopsy; Brain; Brain Neoplasms; gamma-Aminobutyric Acid; Gene Expression Profil	2017
In vivo characterization of brain metabolism by International journal of cancer, 2018, 07-01, Volume: 143, Issue:1 Topics: Adaptor Proteins, Signal Transducing; Animals; Aspartic Acid; Brain; Brain Neoplasms; Cell Line, Tum	2018
A comparative study of short- and long-TE ¹H MRS at 3 T for in vivo detection of 2-hydroxyglutarate in brain tumors. NMR in biomedicine, 2013, Volume: 26, Issue:10 Topics: Adult; Aspartic Acid; Brain Neoplasms; gamma-Aminobutyric Acid; Glioma; Glutamic Acid; Glutamine; Gl	2013
Human breast cancer metastases to the brain display GABAergic properties in the neural niche. Proceedings of the National Academy of Sciences of the United States of America, 2014, Jan-21, Volume: 111, Issue:3 Topics: 4-Aminobutyrate Transaminase; Brain Neoplasms; Breast Neoplasms; Cell Adhesion Molecules, Neuronal;	2014
Cortical GABAergic excitation contributes to epileptic activities around human glioma. Science translational medicine, 2014, Jul-09, Volume: 6, Issue:244 Topics: Action Potentials; Brain Neoplasms; Chlorides; Epilepsy; gamma-Aminobutyric Acid; Glioma; Glutamates	2014
GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy. Glia, 2015, Volume: 63, Issue:1 Topics: Animals; Brain Neoplasms; Epilepsy; Female; gamma-Aminobutyric Acid; Glioma; Interneurons; K Cl- Cot	2015
A role for intracellular zinc in glioma alteration of neuronal chloride equilibrium. Cell death & disease, 2014, Oct-30, Volume: 5 Topics: Animals; Brain Neoplasms; Chlorides; Coculture Techniques; Female; gamma-Aminobutyric Acid; Glioma;	2014
Why glioma patients seize: adding more pathological GABA to the glutamate hypothesis. Neurosurgery, 2014, Volume: 75, Issue:6 Topics: Animals; Brain Neoplasms; gamma-Aminobutyric Acid; Glioma; Glutamic Acid; Humans; Seizures	2014
Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma. Cell reports, 2014, Nov-06, Volume: 9, Issue:3 Topics: Animals; Apoptosis; Arginase; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Chromosomes, Mammali	2014
Breast cancer brain metastases: evidence for neuronal-like adaptation in a 'breast-to-brain' transition? Breast cancer research : BCR, 2014, May-06, Volume: 16, Issue:3 Topics: 4-Aminobutyrate Transaminase; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Female; GABA	2014
Compromised GABAergic inhibition contributes to tumor-associated epilepsy. Epilepsy research, 2016, Volume: 126 Topics: Animals; Brain; Brain Neoplasms; Bumetanide; Cell Line, Tumor; Disease Models, Animal; Epilepsy; gam	2016
A Potential Magnetic Resonance Imaging Technique Based on Chemical Exchange Saturation Transfer for In Vivo γ-Aminobutyric Acid Imaging. PloS one, 2016, Volume: 11, Issue:10 Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; gamma-Aminobutyric Acid; Magnetic Resonance Imaging;	2016
A driver role for GABA metabolism in controlling stem and proliferative cell state through GHB production in glioma. Acta neuropathologica, 2017, Volume: 133, Issue:4 Topics: Aged; Animals; Brain; Brain Neoplasms; Carcinogenesis; Cell Death; Cell Proliferation; Child; Child,	2017
Gamma-aminobutyric acid inhibits synergistic interleukin-6 release but not transcriptional activation in astrocytoma cells. Neuroimmunomodulation, 2008, Volume: 15, Issue:2 Topics: Animals; Astrocytes; Astrocytoma; Brain Neoplasms; Cell Line, Tumor; Down-Regulation; Enzyme-Linked	2008
Pregabalin in patients with primary brain tumors and seizures: a preliminary observation. Clinical neurology and neurosurgery, 2009, Volume: 111, Issue:2 Topics: Adult; Aged; Anticonvulsants; Brain Neoplasms; Epilepsies, Partial; Female; Follow-Up Studies; gamma	2009
Impaired hippocampal synaptic plasticity in C6 glioma-bearing rats. Journal of neuro-oncology, 2011, Volume: 103, Issue:3 Topics: Animals; Body Weight; Brain Neoplasms; Cell Line, Tumor; Chromatography, High Pressure Liquid; Disea	2011
Anomalous levels of Cl- transporters cause a decrease of GABAergic inhibition in human peritumoral epileptic cortex. Epilepsia, 2011, Volume: 52, Issue:9 Topics: Adult; Aged; Animals; Biophysics; Brain Neoplasms; Cerebral Cortex; Electric Stimulation; Epilepsy;	2011
Phenytoin, levetiracetam, and pregabalin in the acute management of refractory status epilepticus in patients with brain tumors. Neurocritical care, 2012, Volume: 16, Issue:1 Topics: Acute Disease; Aged; Anticonvulsants; Brain Neoplasms; Drug Therapy, Combination; Female; gamma-Amin	2012
Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors. NMR in biomedicine, 2012, Volume: 25, Issue:10 Topics: Animals; Brain Neoplasms; Carcinoma, Renal Cell; Citric Acid Cycle; Disease Models, Animal; gamma-Am	2012
GABA-A channel subunit expression in human glioma correlates with tumor histology and clinical outcome. PloS one, 2012, Volume: 7, Issue:5 Topics: Adult; Brain Neoplasms; Chloride Channels; Female; gamma-Aminobutyric Acid; Glioma; Humans; Kaplan-M	2012
Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study. Epileptic disorders : international epilepsy journal with videotape, 2012, Volume: 14, Issue:4 Topics: Adult; Aged; Anticonvulsants; Anxiety; Benzodiazepines; Brain Neoplasms; Carbamazepine; Clobazam; Dr	2012
Detection of elevated glutathione in meningiomas by quantitative in vivo 1H MRS. Magnetic resonance in medicine, 2003, Volume: 49, Issue:4 Topics: Astrocytoma; Brain Chemistry; Brain Neoplasms; gamma-Aminobutyric Acid; Glutathione; Humans; Magneti	2003
The gamma-aminobutyric acid content and glutamate decarboxylase activity of brain tumours. Journal of neurochemistry, 1963, Volume: 10 Topics: Amino Acids; Brain Neoplasms; Carboxy-Lyases; Electrophoresis; gamma-Aminobutyric Acid; Glutamate De	1963
Hiccup in patients with advanced cancer successfully treated with gabapentin: report of three cases. The New Zealand medical journal, 2003, Sep-26, Volume: 116, Issue:1182 Topics: Acetates; Adult; Amines; Anticonvulsants; Brain Neoplasms; Carcinoma, Small Cell; Colonic Neoplasms;	2003
The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels. Anesthesiology, 2006, Volume: 104, Issue:5 Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Anesthetics, Inhalation; Apoptosis; Blotting,	2006
Simultaneous detection of resolved glutamate, glutamine, and gamma-aminobutyric acid at 4 T. Journal of magnetic resonance (San Diego, Calif. : 1997), 2007, Volume: 185, Issue:2 Topics: Algorithms; Brain; Brain Neoplasms; Complex Mixtures; gamma-Aminobutyric Acid; Glutamic Acid; Glutam	2007
3.0-T functional brain imaging: a 5-year experience. La Radiologia medica, 2007, Volume: 112, Issue:1 Topics: Artifacts; Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Cerebral Arteries; Cerebral Cortex	2007
Gene expression profile analysis of epilepsy-associated gangliogliomas. Neuroscience, 2008, Jan-02, Volume: 151, Issue:1 Topics: Adult; Brain Neoplasms; Cell Adhesion; Complement System Proteins; DNA Primers; Epilepsy; Extracellu	2008
[Benzodiazepine receptors of the mouse glioblastoma cell line: the anomalous effect of gamma-aminobutyric acid on diazepam binding]. Doklady Akademii nauk SSSR, 1982, Volume: 267, Issue:6 Topics: Animals; Benzodiazepines; Brain Neoplasms; Cell Line; Cells, Cultured; Diazepam; gamma-Aminobutyric	1982
[New type of specific binding sites for gamma-aminobutyric acid (GABA) found in a mouse glioblastoma]. Doklady Akademii nauk SSSR, 1983, Volume: 272, Issue:5 Topics: Animals; Binding Sites; Brain Neoplasms; Cell Line; Cells, Cultured; gamma-Aminobutyric Acid; Glioma	1983
Plasma and cerebrospinal fluid gamma-aminobutyric acid in neurological disorders. Journal of neurology, neurosurgery, and psychiatry, 1982, Volume: 45, Issue:10 Topics: Brain Neoplasms; Cerebral Infarction; Epilepsy; Female; gamma-Aminobutyric Acid; Humans; Male; Menin	1982
[Effects of 3-methylcholanthrene and 3-methylcholanthrene plus piracetam on the gamma-amino-butyric acid (GABA) content of several cerebral regions (author's transl)]. Journal of cancer research and clinical oncology, 1981, Volume: 101, Issue:3 Topics: Aminooxyacetic Acid; Animals; Brain Chemistry; Brain Neoplasms; gamma-Aminobutyric Acid; Methylchola	1981
Add-on gabapentin for refractory seizures in patients with brain tumours. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1996, Volume: 23, Issue:2 Topics: Acetates; Amines; Anticonvulsants; Brain Neoplasms; Cyclohexanecarboxylic Acids; Follow-Up Studies;	1996
[Drug-resistant epilepsy]. Revista de neurologia, 1998, Volume: 27, Issue:159 Topics: Adult; Anticonvulsants; Brain Neoplasms; Calcinosis; Carbamazepine; Diagnosis, Differential; Drug Re	1998
[1-(13)C]glucose metabolism in the tumoral and nontumoral cerebral tissue of a glioma-bearing rat. Journal of neurochemistry, 1999, Volume: 72, Issue:6 Topics: Alanine; Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Body Weight; Brain; Brain Neopla	1999
Characterization of neocortical and hippocampal synaptosomes from temporal lobe epilepsy patients. Brain research, 1999, Aug-07, Volume: 837, Issue:1-2 Topics: Adult; Animals; Brain Neoplasms; Calcium; Epilepsy, Temporal Lobe; Female; gamma-Aminobutyric Acid;	1999
Free amino acids and related substances in human glial tumours and in fetal brain: comparison with normal adult brain. Brain research, 1976, Nov-19, Volume: 117, Issue:1 Topics: Adult; Age Factors; Aged; Amino Acids; Brain Chemistry; Brain Neoplasms; Female; Fetus; gamma-Aminob	1976
Glial cell characteristics in bulk-prepared cell fractions from human brain tumours. Acta neuropathologica, 1977, Nov-28, Volume: 40, Issue:3 Topics: Astrocytoma; Brain Neoplasms; Cell Separation; Centrifugation, Density Gradient; gamma-Aminobutyric	1977
Changes in gamma-aminobutyric acid and somatostatin in epileptic cortex associated with low-grade gliomas. Journal of neurosurgery, 1992, Volume: 77, Issue:2 Topics: Brain Neoplasms; Epilepsy; gamma-Aminobutyric Acid; Glioma; Humans; Immunohistochemistry; Neurons; S	1992
Monoamine content in rat brain during carcinogenesis and the influence of the CNS drugs piracetam and imipramine. Die Naturwissenschaften, 1985, Volume: 72, Issue:10 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Brain Neoplasms; Caudate Nucleus; Female;	1985
Amino acid neurotransmitter levels in gliomas and their relationship to the incidence of epilepsy. Neurological research, 1988, Volume: 10, Issue:2 Topics: Amino Acids; Brain Neoplasms; Epilepsy; gamma-Aminobutyric Acid; Glioma; Glutamine; Humans; Neurotra	1988
Characterization of the gamma-aminobutyric acid receptor system in human brain gliomas. Cancer research, 1985, Volume: 45, Issue:9 Topics: Brain Neoplasms; gamma-Aminobutyric Acid; Glioma; Humans; In Vitro Techniques; Kinetics; Receptors,	1985
[Hemiballism caused by metastasis to Luys' body]. Revue neurologique, 1985, Volume: 141, Issue:12 Topics: Adenocarcinoma; Aged; Basal Ganglia Diseases; Brain Neoplasms; Diencephalon; gamma-Aminobutyric Acid	1985

gamma-aminobutyric acid and Brain Neoplasms