gamma-aminobutyric acid has been researched along with Brain Ischemia in 207 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this review, we present evidence for the role of gamma-aminobutyric acid (GABA) neurotransmission in cerebral ischemia-induced neuronal death." | 8.81 | gamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia. ( Sah, R; Schwartz-Bloom, RD, 2001) |
| "Compositions of phenibut with salicylic, nicotinic, and glutamic acids in subtotal and transient cerebral ischemia were found to have the most pronounced cerebroprotective effect in doses of 30, 50 and 50 mg/kg, respectively." | 8.31 | Experimental Substantiation of the Use of Phenibut Combinations with Salicylic, Nicotinic, and Glutamic Acids in Cerebral Ischemia. ( Monov, D; Pashanova, O, 2023) |
| "Dexmedetomidine is capable of decreasing glutamergic content, and increasing GABAergic content, in order to decrease the injury of the cerebral ultrastructure, following cerebral ischemia-reperfusion injury." | 7.85 | Impact of dexmedetomidine on amino acid contents and the cerebral ultrastructure of rats with cerebral ischemia-reperfusion injury. ( Fu, Z; Lin, S; Shao, W; Zhou, G, 2017) |
| "To investigate the effects of dexmedetomidine (DEX) on amino acid contents and the cerebral ultrastructure of rats with cerebral ischemia-reperfusion injury (I/R)." | 7.85 | Impact of dexmedetomidine on amino acid contents and the cerebral ultrastructure of rats with cerebral ischemia-reperfusion injury. ( Fu, Z; Lin, S; Shao, W; Zhou, G, 2017) |
| "To observe the effects of L-tetrahydropalmatine (L-THP) on concentrations of neurotransmitter amino acids in mice with cerebral ischemia and to discuss the mechanisms of L-THP in tyreating cerebral ischemia." | 7.72 | [Effects of L-tetrahydropalmatine on concentrations of neurotransmitter amino acids in mice with cerebral ischemia]. ( Jiang, B; Zhang, ZM; Zheng, XX; Zhou, Q, 2004) |
| " This study investigates the utilization of glutamate, glutamine, and GABA as fuel by the neuronal and glial tricarboxylic acid cycles of both cerebral hemispheres after partially reversible focal cerebral ischemia (FCI)." | 7.70 | Glutamate, glutamine, and GABA as substrates for the neuronal and glial compartments after focal cerebral ischemia in rats. ( Carceller, F; Cerdán, S; Pascual, JM; Roda, JM, 1998) |
| "The releases of endogenous glutamate, aspartate, GABA and taurine from hippocampal slices from 7-day-, 3-, 12-, and 18-month-old mice were investigated under cell-damaging conditions using a superfusion system." | 7.70 | Release of endogenous glutamate, aspartate, GABA, and taurine from hippocampal slices from adult and developing mice under cell-damaging conditions. ( Oja, SS; Saransaari, P, 1998) |
| " We, therefore, investigated whether the presumed higher firing frequency and metabolic activity of neurons in such hypoxia-damaged cortical areas would be reflected by an enhanced light microscopic immunoreactivity of gamma-aminobutyric acid (GABA), the two isoforms of glutamic acid decarboxylase (GAD67 and GAD65), the mitochondrial enzymes cytochrome c oxidase and ATP synthase, and/or glial fibrillary acidic, protein (GFAP)." | 7.69 | Permanent increase of immunocytochemical reactivity for gamma-aminobutyric acid (GABA), glutamic acid decarboxylase, mitochondrial enzymes, and glial fibrillary acidic protein in rat cerebral cortex damaged by early postnatal hypoxia-ischemia. ( Janszen, AW; Romijn, HJ; Van den Bogert, C, 1994) |
| "An experimental model of amnesia induced by cerebral ischemia after one-trial passive avoidance learning was established to test the effects of a novel compound, 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone, CV-2619), and some commonly used drugs in rats." | 7.67 | Beneficial effect of idebenone (CV-2619) on cerebral ischemia-induced amnesia in rats. ( Nagaoka, A; Nagawa, Y; Take, Y; Yamazaki, N, 1984) |
| "We present a review of the effects of cerebral ischemia on pre and postsynaptic targets within the GABAergic synapse." | 6.41 | gamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia. ( Sah, R; Schwartz-Bloom, RD, 2001) |
| "We measured 4 plasma amino acid neurotransmitters (glutamic acid, aspartic acid, gamma-aminobutyric acid, and glycine) among 3486 patients with ischemic stroke from 26 hospitals across China." | 5.69 | Plasma Amino Acid Neurotransmitters and Ischemic Stroke Prognosis: A Multicenter Prospective Study. ( Chen, J; Guo, D; He, J; Jia, Y; Peng, H; Shi, M; Sun, L; Wang, A; Wang, Y; Xu, Q; Xu, T; Yang, P; Zhang, Y; Zhong, C; Zhu, Z, 2023) |
| "Increased glutamic acid, aspartic acid, and gamma-aminobutyric acid and decreased glycine in plasma are associated with adverse outcomes after ischemic stroke, suggesting that plasma amino acid neurotransmitters may be potential intervention targets for improving prognosis of ischemic stroke." | 5.69 | Plasma Amino Acid Neurotransmitters and Ischemic Stroke Prognosis: A Multicenter Prospective Study. ( Chen, J; Guo, D; He, J; Jia, Y; Peng, H; Shi, M; Sun, L; Wang, A; Wang, Y; Xu, Q; Xu, T; Yang, P; Zhang, Y; Zhong, C; Zhu, Z, 2023) |
| "Acute seizure activity was behaviorally scored and hemispheric brain atrophy measured." | 5.35 | Gabapentin neuroprotection and seizure suppression in immature mouse brain ischemia. ( Comi, AM; Johnston, MV; Kadam, SD; Mulholland, JD; Traa, BS, 2008) |
| "Seizures were detected by continuous electroencephalographic monitoring for 24 h following permanent middle cerebral artery occlusion (MCAo)." | 5.33 | Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats. ( Bautista, CC; Chen, RW; Dave, JR; Hartings, JA; Lu, XC; Tortella, FC; Williams, AJ, 2006) |
| "Acute seizures following brain injury have been associated with a worsening of patient outcome, but they are often undiagnosed and untreated when they occur without motor convulsions." | 5.33 | Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats. ( Bautista, CC; Chen, RW; Dave, JR; Hartings, JA; Lu, XC; Tortella, FC; Williams, AJ, 2006) |
| "Taurine release was doubled in hypoxia and tripled in ischemia but K+ stimulation was abolished." | 5.30 | Release of endogenous glutamate, aspartate, GABA, and taurine from hippocampal slices from adult and developing mice under cell-damaging conditions. ( Oja, SS; Saransaari, P, 1998) |
| "Nitric oxide release during cerebral ischemia is the result of both neuronal and endothelial subclasses of nitric oxide synthase (NOS)." | 5.30 | Modulation of ischemic excitatory neurotransmitter and gamma-aminobutyric acid release during global temporary cerebral ischemia by selective neuronal nitric oxide synthase inhibition. ( Kahn, RA; Panah, M; Weinberger, J, 1997) |
| "A former study indicated that hypoxic-ischemic encephalopathy in rat sustained during early postnatal life may result in permanent epileptic activity in the baseline electroencephalogram." | 5.29 | Permanent increase of immunocytochemical reactivity for gamma-aminobutyric acid (GABA), glutamic acid decarboxylase, mitochondrial enzymes, and glial fibrillary acidic protein in rat cerebral cortex damaged by early postnatal hypoxia-ischemia. ( Janszen, AW; Romijn, HJ; Van den Bogert, C, 1994) |
| "Muscimol was infused into the third ventricle continuously for 7 days beginning just prior to the insult." | 5.29 | GABA agonist "muscimol" is neuroprotective in repetitive transient forebrain ischemia in gerbils. ( Ijaz, S; Mazagri, R; Shuaib, A, 1993) |
| "The amnesia was estimated by the response latency for a rat to step from a light safety compartment to a dark compartment in which a foot-shock was given." | 5.27 | Beneficial effect of idebenone (CV-2619) on cerebral ischemia-induced amnesia in rats. ( Nagaoka, A; Nagawa, Y; Take, Y; Yamazaki, N, 1984) |
| "In this review, we present evidence for the role of gamma-aminobutyric acid (GABA) neurotransmission in cerebral ischemia-induced neuronal death." | 4.81 | gamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia. ( Sah, R; Schwartz-Bloom, RD, 2001) |
| "Compositions of phenibut with salicylic, nicotinic, and glutamic acids in subtotal and transient cerebral ischemia were found to have the most pronounced cerebroprotective effect in doses of 30, 50 and 50 mg/kg, respectively." | 4.31 | Experimental Substantiation of the Use of Phenibut Combinations with Salicylic, Nicotinic, and Glutamic Acids in Cerebral Ischemia. ( Monov, D; Pashanova, O, 2023) |
| "To investigate the effects of dexmedetomidine (DEX) on amino acid contents and the cerebral ultrastructure of rats with cerebral ischemia-reperfusion injury (I/R)." | 3.85 | Impact of dexmedetomidine on amino acid contents and the cerebral ultrastructure of rats with cerebral ischemia-reperfusion injury. ( Fu, Z; Lin, S; Shao, W; Zhou, G, 2017) |
| "Dexmedetomidine is capable of decreasing glutamergic content, and increasing GABAergic content, in order to decrease the injury of the cerebral ultrastructure, following cerebral ischemia-reperfusion injury." | 3.85 | Impact of dexmedetomidine on amino acid contents and the cerebral ultrastructure of rats with cerebral ischemia-reperfusion injury. ( Fu, Z; Lin, S; Shao, W; Zhou, G, 2017) |
| "Cerebroprotective activity of phenyl derivatives of GABA (phenibut, 25 mg/kg) and L-glutamic acid (neuroglutam, 26 mg/kg) in rats with cerebral ischemia was studied on the background of intact and altered immunoreactivity." | 3.83 | NEUROPROTECTIVE ACTION OF PHENIBUT AND NEUROGLUTAM IN EXPERIMENTAL CEREBRAL ISCHEMIA ON THE BACKGROUND OF ALTERED IMMUNOREACTIVITY. ( Bakulin, DA; Filina, IS; Kurkin, DV; Tyurenkov, IN; Volotova, EV, 2016) |
| " It is established that cerebrovascular activity of the GABA conjugate with prostaglandin E2 under conditions of cerebral ischemia is based on GABAergic mechanisms of vascular tone regulation, since it is removed by GABA(A)-receptor blocker bicuculline." | 3.79 | [Cerebrovascular effects of GABA-prostaglandin E2 conjugate in comparison with prostaglandin E2]. ( Bezuglov, VV; Gan'shina, TS; Gorbunova, AV; Gretskaia, NM; Mirzoian, RS, 2013) |
| " Although a number of studies have investigated that ginkgolide B, a purified terpene lactone component extracted from Ginkgo biloba leaves, is available "platelet activating factor (PAF) receptors antagonist", "antioxidant" with a variety of actions, very little has been performed to explore the effect of ginkgolide B on extracellular amino acids in experimental animal of focal cerebral ischemia/reperfusion." | 3.77 | Effect of ginkgolide B on striatal extracellular amino acids in middle cerebral artery occluded rats. ( Feng, W; Li, J; Li, SX; Wang, H; Yang, ZZ, 2011) |
| "Our latest study indicated that ethanol could attenuate cerebral ischemia/reperfusion-induced brain injury through activating Ionotropic glutamate receptors Kainate Family (Gluk1)-kainate (KA) receptors and gamma-aminobutyric acid (GABA) receptors." | 3.76 | Neuroprotection of ethanol against ischemia/reperfusion-induced brain injury through decreasing c-Jun N-terminal kinase 3 (JNK3) activation by enhancing GABA release. ( Gu, YH; Guan, QH; Hao, LY; Liu, Y; Qi, SH; Wang, M; Yan, H; Zhang, GY; Zhang, J, 2010) |
| "This study investigated the possible involvement of gamma-aminobutyric acid (GABA) in the therapeutic effect of cerebral ischemia by electro-acupuncture (EA) using the rat model with middle cerebral artery occlusion (MCAO)." | 3.73 | Role of GABA in electro-acupuncture therapy on cerebral ischemia induced by occlusion of the middle cerebral artery in rats. ( Cheng, JS; Gan, P; Ling, EA; Ng, YK, 2005) |
| " The neuromodulator adenosine is known to inhibit the presynaptic release of neurotransmitters and to hyperpolarize postsynaptic neurons in the hippocampus, which would imply that it is an endogenous protective agent against cerebral ischemia and excitotoxic neuronal damage." | 3.73 | GABA release modified by adenosine receptors in mouse hippocampal slices under normal and ischemic conditions. ( Oja, SS; Saransaari, P, 2005) |
| "To observe the effects of L-tetrahydropalmatine (L-THP) on concentrations of neurotransmitter amino acids in mice with cerebral ischemia and to discuss the mechanisms of L-THP in tyreating cerebral ischemia." | 3.72 | [Effects of L-tetrahydropalmatine on concentrations of neurotransmitter amino acids in mice with cerebral ischemia]. ( Jiang, B; Zhang, ZM; Zheng, XX; Zhou, Q, 2004) |
| "Experimental studies have suggested that ischemic stroke causes increment in extracellular level of gamma-aminobutyric acid in response to excessive glutamate concentration and function." | 3.72 | GABA in ischemic stroke. Proton magnetic resonance study. ( Głodzik-Sobańska, L; Kozub, J; Sobiecka, B; Szczudlik, A; Słowik, A; Urbanik, A, 2004) |
| "To test the hypothesis of an involvement of tachykinins in destabilization and hyperexcitation of neuronal circuits, gliosis, and neuroinflammation during cerebral ischemia, we investigated cell-specific expressional changes of the genes encoding substance P (SP), neurokinin B (NKB), and the tachykinin/neurokinin receptors (NK1, NK2, and NK3) after middle cerebral artery occlusion (MCAO) in the rat." | 3.71 | Adaptive plasticity in tachykinin and tachykinin receptor expression after focal cerebral ischemia is differentially linked to gabaergic and glutamatergic cerebrocortical circuits and cerebrovenular endothelium. ( Culmsee, C; Krieglstein, J; Schafer, MK; Stumm, R; Weihe, E, 2001) |
| " Therefore, it was aimed to study whether dipyridamole (CAS 58-32-2), an adenosine uptake inhibitor, or adenosine (CAS 58-61-7) could affect the rat brain gamma-aminobutyric acid (GABA, CAS 56-12-2) level after induction of cerebral ischemia, and to test their effect on the lactate dehydrogenase (LDH) activity of the ischemic rat brain." | 3.71 | Influence of inhibition of adenosine uptake on the gamma-aminobutyric acid level of the ischemic rat brain. ( Khattab, M; Seif-el-Nasr, M, 2002) |
| "The releases of endogenous glutamate, aspartate, GABA and taurine from hippocampal slices from 7-day-, 3-, 12-, and 18-month-old mice were investigated under cell-damaging conditions using a superfusion system." | 3.70 | Release of endogenous glutamate, aspartate, GABA, and taurine from hippocampal slices from adult and developing mice under cell-damaging conditions. ( Oja, SS; Saransaari, P, 1998) |
| " This study investigates the utilization of glutamate, glutamine, and GABA as fuel by the neuronal and glial tricarboxylic acid cycles of both cerebral hemispheres after partially reversible focal cerebral ischemia (FCI)." | 3.70 | Glutamate, glutamine, and GABA as substrates for the neuronal and glial compartments after focal cerebral ischemia in rats. ( Carceller, F; Cerdán, S; Pascual, JM; Roda, JM, 1998) |
| " Concentrations of extracellular amino acids (glutamate, aspartate, gamma-aminobutyric acid (GABA) and taurine) and regional blood flow in the striatum of spontaneously hypertensive rats (SHRs) were monitored during cerebral ischemia elicited by bilateral carotid artery occlusion for 40 min and recirculation." | 3.70 | Modulation of ischemia-evoked release of excitatory and inhibitory amino acids by adenosine A1 receptor agonist. ( Fujishima, M; Goda, H; Ibayashi, S; Nakane, H; Ooboshi, H; Sadoshima, S, 1998) |
| "To investigate global cerebral ischemia-induced alterations in the levels of glutamate, aspartate, gamma-aminobutyric acid (GABA), glutamine, glycine, and taurine from hippocampus, striatum, and cerebral cortex in gerbils." | 3.70 | Alterations of amino acid levels from striatum, hippocampus, and cerebral cortex induced by global cerebral ischemia in gerbil. ( Hu, G; Rao, MR; Tang, XC; Wang, H, 2000) |
| "The increases of glutamate, aspartate, glycine, and glutamine induced by acute global cerebral ischemia may constitute the biochemical basis of ischemic brain damage." | 3.70 | Alterations of amino acid levels from striatum, hippocampus, and cerebral cortex induced by global cerebral ischemia in gerbil. ( Hu, G; Rao, MR; Tang, XC; Wang, H, 2000) |
| " We, therefore, investigated whether the presumed higher firing frequency and metabolic activity of neurons in such hypoxia-damaged cortical areas would be reflected by an enhanced light microscopic immunoreactivity of gamma-aminobutyric acid (GABA), the two isoforms of glutamic acid decarboxylase (GAD67 and GAD65), the mitochondrial enzymes cytochrome c oxidase and ATP synthase, and/or glial fibrillary acidic, protein (GFAP)." | 3.69 | Permanent increase of immunocytochemical reactivity for gamma-aminobutyric acid (GABA), glutamic acid decarboxylase, mitochondrial enzymes, and glial fibrillary acidic protein in rat cerebral cortex damaged by early postnatal hypoxia-ischemia. ( Janszen, AW; Romijn, HJ; Van den Bogert, C, 1994) |
| "Cerebrospinal fluid (CSF) concentrations of glutamate and gamma- aminobutyric acid (GABA), as estimates of levels in the extracellular compartment of brain, were determined in 7-day postnatal rats at the terminus of hypoxia-ischemia and during status epilepticus, induced with bicuculline, at 2 and 24 h of recovery." | 3.69 | Cerebrospinal fluid concentrations of glutamate and GABA during perinatal cerebral hypoxia-ischemia and seizures. ( Cataltepe, O; Towfighi, J; Vannucci, RC, 1996) |
| "The involvement of phospholipases in ischemia-evoked release of aspartate, glutamate, glycine, and GABA from the cerebral cortex was studied in a four vessel occlusion rat model of cerebral ischemia/reperfusion." | 3.69 | A possible role for phospholipases in the release of neurotransmitter amino acids from ischemic rat cerebral cortex. ( O'Regan, MH; Perkins, LM; Phillis, JW; Smith-Barbour, M, 1995) |
| "The effects of indomethacin (10 mg/kg) on the release of the transmitter amino acids, glutamate, aspartate, GABA, and of the purines, adenosine and inosine, from the cerebral cortex was studied in a four-vessel occlusion rat model of cerebral ischemia/reperfusion." | 3.69 | Indomethacin modulates ischemia-evoked release of glutamate and adenosine from the rat cerebral cortex. ( O'Regan, MH; Perkins, LM; Phillis, JW; Smith-Barbour, M, 1994) |
| "Using a repeated acquisition procedure in a 3-panel runway apparatus, the effect of WEB 1881 FU on impairment of working memory produced either by scopolamine or by cerebral ischemia was investigated in rats and compared with those of aniracetam and Ca hopantenate." | 3.68 | WEB 1881 FU ameliorates impairment of working memory induced by scopolamine and cerebral ischemia in the three-panel runway task. ( Kitajima, I; Ohno, M; Ueki, S; Yamamoto, T, 1990) |
| "The extracellular concentrations of aspartate, glutamate, glutamine, taurine and gamma-aminobutyric acid in the hippocampus were determined during and after forebrain ischemia (4-vessel model) in the unanaesthetized rat." | 3.68 | Concomitant increases in the extracellular concentrations of excitatory and inhibitory amino acids in the rat hippocampus during forebrain ischemia. ( Boulu, RG; Callebert, J; Lekieffre, D; Plotkine, M, 1992) |
| "An experimental model of amnesia induced by cerebral ischemia after one-trial passive avoidance learning was established to test the effects of a novel compound, 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone, CV-2619), and some commonly used drugs in rats." | 3.67 | Beneficial effect of idebenone (CV-2619) on cerebral ischemia-induced amnesia in rats. ( Nagaoka, A; Nagawa, Y; Take, Y; Yamazaki, N, 1984) |
| " Number and type of adverse events were similar between the three groups." | 2.94 | Safety and efficacy of GABA ( Audoli-Inthavong, ML; Bassetti, CL; Chabriat, H; Hermann, DM; Lambert, E; Marx, U; Sors, A; Wattez, M, 2020) |
| "Cerebral ischemia is a multi-faceted neurodegenerative pathology that causes cellular injury to neurons within the central nervous system." | 2.44 | Anesthetic-mediated protection/preconditioning during cerebral ischemia. ( Clarkson, AN, 2007) |
| "We present a review of the effects of cerebral ischemia on pre and postsynaptic targets within the GABAergic synapse." | 2.41 | gamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia. ( Sah, R; Schwartz-Bloom, RD, 2001) |
| "Cerebral ischemia is the leading cause for long-term disability and mortality in adults due to massive neuronal death." | 1.91 | Targeting the interaction of GABA ( Balakrishnan, K; Benke, D; Bhat, MA; Ganley, RP; Hleihil, M; Klohs, J; Vaas, M; Zeilhofer, HU, 2023) |
| "This study utilized a cerebral ischemia reperfusion (IR) model to produce a stressful brain condition that highlights the possible involvement of a hippocampal GC/pERK1/2/BDNF pathway in the resulting sexual consequences of this ailment." | 1.72 | Insights into the role of pERK1/2 signaling in post-cerebral ischemia reperfusion sexual dysfunction in rats. ( El-Sahar, AE; Khattab, MA; Mohammed, RA; Saad, MA; Sayed, RH, 2022) |
| "Waggle needling, a classical anti-spastic needling technique characterized by combination of acupuncture with joint movement, has gained increasing popularity of spasticity treatment in China." | 1.56 | Waggle needling wields preferable neuroprotective and anti-spastic effects on post-stroke spasticity rats by attenuating γ-aminobutyric acid transaminase and enhancing γ-aminobutyric acid. ( Gan, YY; Guo, MW; Li, JL; Ma, LX; Mu, JD; Qian, X; Ren, XX; Song, Y; Sun, TY; Tian, Y; Wang, JX; Yu, WY, 2020) |
| "Memantine was used as a positive control." | 1.43 | Low dose of L-glutamic acid attenuated the neurological dysfunctions and excitotoxicity in bilateral common carotid artery occluded mice. ( Abdul, KK; Justin, A; Ramanathan, M, 2016) |
| "The mechanical allodynia was significantly increased on day 3 after BCAO compared with that during the pre-BCAO assessment." | 1.43 | Effects of Adjuvant Analgesics on Cerebral Ischemia-Induced Mechanical Allodynia. ( Harada, S; Matsuura, W; Tokuyama, S, 2016) |
| "The development of hind paw mechanical allodynia was measured after BCAO using the von Frey test." | 1.43 | Effects of Adjuvant Analgesics on Cerebral Ischemia-Induced Mechanical Allodynia. ( Harada, S; Matsuura, W; Tokuyama, S, 2016) |
| "Those that developed cerebral ischemia after MCAO were randomized to receive propylene glycol salt water and ligustrazine respectively." | 1.40 | Effect of ligustrazine on levels of amino acid neurotransmitters in rat striatum after cerebral ischemia-reperfusion injury. ( Bie, XD; Ge, LJ; Han, J; Wan, HT; Yang, JH; Zhang, YY, 2014) |
| "Conversely, in painted turtle brain anoxia increases γ-amino butyric acid (GABA)ergic suppression of spontaneous electrical activity, and cell death is prevented." | 1.38 | Painted turtle cortex is resistant to an in vitro mimic of the ischemic mammalian penumbra. ( Buck, LT; Gu, XQ; Haddad, GG; Hogg, DW; Pamenter, ME, 2012) |
| "It is shown that, in rats with global cerebral ischemia modeled by a complete irreversible occlusion of the common carotid artery and forced hypotension, the hemostasis is characterized by a shift toward hypercoagulation." | 1.38 | [Effect of phenibut and its composition with nicotinic acid on hemostasis in rats with brain ischemia]. ( Kurkin, DV; Litvinov, AA; Tarasov, AS; Tiurenkov, IN; Volotova, EV, 2012) |
| "Gabapentin pretreatment (200 mg/kg, intravenously) reduced the infarct volume by 23% after transient focal ischemia in mice." | 1.37 | Gabapentin reduces infarct volume but does not suppress peri-infarct depolarizations. ( Ayata, C; Eikermann-Haerter, K; Hoffmann, U; Lee, JH; Qin, T, 2011) |
| "Cell death in cerebral ischemia is presumably initiated by neural excitotoxicity resulted from the dysfunction of inhibitory neurons in early stage." | 1.36 | Ca2+ and acidosis synergistically lead to the dysfunction of cortical GABAergic neurons during ischemia. ( Chen, N; Ge, M; Guan, S; Huang, L; Wang, JH; Zhu, Y, 2010) |
| "Acute seizure activity was behaviorally scored and hemispheric brain atrophy measured." | 1.35 | Gabapentin neuroprotection and seizure suppression in immature mouse brain ischemia. ( Comi, AM; Johnston, MV; Kadam, SD; Mulholland, JD; Traa, BS, 2008) |
| "After training, cerebral ischemia was induced by MCAO for 120 min, followed by reperfusion." | 1.35 | Pre-ischemic treadmill training affects glutamate and gamma aminobutyric acid levels in the striatal dialysate of a rat model of cerebral ischemia. ( Cao, ZJ; Hu, YS; Jia, J; Liu, G; Wu, Y; Xia, CM; Yu, HX; Zheng, QP; Zhu, DN, 2009) |
| "After global cerebral ischemia, delayed cell death is observed in the thalamic reticular nucleus but the mechanisms involved are not well described." | 1.35 | Endonuclease G expression in thalamic reticular nucleus after global cerebral ischemia. ( Diemer, NH; Nielsen, M; Zimmer, J, 2008) |
| "Ischemia was induced by a 1 h transient middle cerebral artery occlusion (MCAO) in spontaneously hypertensive rats." | 1.33 | Decreased expression of vesicular GABA transporter, but not vesicular glutamate, acetylcholine and monoamine transporters in rat brain following focal ischemia. ( Vemuganti, R, 2005) |
| "Seizures were detected by continuous electroencephalographic monitoring for 24 h following permanent middle cerebral artery occlusion (MCAo)." | 1.33 | Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats. ( Bautista, CC; Chen, RW; Dave, JR; Hartings, JA; Lu, XC; Tortella, FC; Williams, AJ, 2006) |
| "Acute seizures following brain injury have been associated with a worsening of patient outcome, but they are often undiagnosed and untreated when they occur without motor convulsions." | 1.33 | Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats. ( Bautista, CC; Chen, RW; Dave, JR; Hartings, JA; Lu, XC; Tortella, FC; Williams, AJ, 2006) |
| "Ten minutes of cerebral ischemia was produced by tightening the carotid ligatures bilaterally following hypotension." | 1.33 | Ischemic preconditioning ameliorates excitotoxicity by shifting glutamate/gamma-aminobutyric acid release and biosynthesis. ( Busto, R; Dave, KR; Lange-Asschenfeldt, C; Pérez-Pinzón, MA; Prado, R; Raval, AP; Saul, I, 2005) |
| " Compared with the model group, the concentration of Glu in the middle and large dosage groups of TGF, during the 120 min of ischemia, reduced by 38." | 1.32 | [Effects of tianma gouteng fang on transmitter amino acids in the hippocampus extracellular liquids in freely moving rats subjected to brain ischemia]. ( Du, GY; Sun, XF; Wang, DQ; Wang, W; Ye, ZG; Zhang, CY; Zhao, DZ, 2004) |
| "Nonconvulsive seizures (NCSs) after traumatic and ischemic brain injury are often refractory to antiepileptic drug therapy and are associated with a decline in patient outcome." | 1.32 | Antiepileptic drug treatment of nonconvulsive seizures induced by experimental focal brain ischemia. ( Hartings, JA; Lu, XM; Moreton, JE; Tortella, FC; Williams, AJ, 2004) |
| "We introduced intracerebral hemorrhage in each of eight anesthetized New Zealand rabbits by injecting 0." | 1.32 | Extracellular glutamate and other amino acids in experimental intracerebral hemorrhage: an in vivo microdialysis study. ( Ali, Z; Baker, G; Guterman, LR; Hopkins, LN; Qureshi, AI; Shuaib, A; Suri, MF; Todd, K, 2003) |
| "Lactic acidosis has been implicated; however, increases in the excitotoxic amino acid glutamate, which correlate with increased neuronal damage, may be the cause for the increased damage seen in hyperglycemic stroke." | 1.31 | The effect of streptozotocin-induced diabetes on the release of excitotoxic and other amino acids from the ischemic rat cerebral cortex. ( Diaz, FG; Guyot, LL; O'Regan, MH; Phillis, JW; Song, D, 2001) |
| "Efflux of glutamate during cerebral ischemia is known to contribute to brain cell death via processes of excitotoxicity." | 1.31 | Profiles of glutamate and GABA efflux in core versus peripheral zones of focal cerebral ischemia in mice. ( Lo, EH; Moskowitz, MA; Newcomb, R; Shimizu-Sasamata, M; Wang, X, 2001) |
| "Dipyridamole was administered alone and in combination with adenosine and the effect of the drugs on the brain GABA level as well as on LDH activity was determined." | 1.31 | Influence of inhibition of adenosine uptake on the gamma-aminobutyric acid level of the ischemic rat brain. ( Khattab, M; Seif-el-Nasr, M, 2002) |
| "The gerbil global cerebral ischemia model was prepared by bilateral carotid artery occlusion; the contents of amino acids were assayed using high performance liquid chromatography (HPLC) combined with fluorescent detection after precolumn derivatization." | 1.31 | Alterations of amino acid levels from striatum, hippocampus, and cerebral cortex induced by global cerebral ischemia in gerbil. ( Hu, G; Rao, MR; Tang, XC; Wang, H, 2000) |
| "Similarly, the global cerebral ischemia resulted in increase by 80%, 69%, and 83% of aspartate contents in hippocampus, striatum, and cortex, respectively." | 1.31 | Alterations of amino acid levels from striatum, hippocampus, and cerebral cortex induced by global cerebral ischemia in gerbil. ( Hu, G; Rao, MR; Tang, XC; Wang, H, 2000) |
| "To investigate global cerebral ischemia-induced alterations in the levels of glutamate, aspartate, gamma-aminobutyric acid (GABA), glutamine, glycine, and taurine from hippocampus, striatum, and cerebral cortex in gerbils." | 1.31 | Alterations of amino acid levels from striatum, hippocampus, and cerebral cortex induced by global cerebral ischemia in gerbil. ( Hu, G; Rao, MR; Tang, XC; Wang, H, 2000) |
| "Adenosine has been reported to have beneficial effects against ischemic brain damage, although the mechanisms are not fully clarified." | 1.30 | Modulation of ischemia-evoked release of excitatory and inhibitory amino acids by adenosine A1 receptor agonist. ( Fujishima, M; Goda, H; Ibayashi, S; Nakane, H; Ooboshi, H; Sadoshima, S, 1998) |
| "Nitric oxide release during cerebral ischemia is the result of both neuronal and endothelial subclasses of nitric oxide synthase (NOS)." | 1.30 | Modulation of ischemic excitatory neurotransmitter and gamma-aminobutyric acid release during global temporary cerebral ischemia by selective neuronal nitric oxide synthase inhibition. ( Kahn, RA; Panah, M; Weinberger, J, 1997) |
| "Repetitive cerebral ischemia produces more severe damage than a similar single duration insult." | 1.30 | GABA and glutamate levels in the substantia nigra reticulata following repetitive cerebral ischemia in gerbils. ( Hussain, S; Ijaz, MS; Kanthan, R; Miyashita, H; Shuaib, A, 1997) |
| "Taurine release was doubled in hypoxia and tripled in ischemia but K+ stimulation was abolished." | 1.30 | Release of endogenous glutamate, aspartate, GABA, and taurine from hippocampal slices from adult and developing mice under cell-damaging conditions. ( Oja, SS; Saransaari, P, 1998) |
| "As indomethacin is a potent inhibitor of adenosine uptake, these results suggest that, by blocking adenosine uptake, indomethacin could elevate extracellular adenosine levels and depress glutamate and aspartate efflux as a consequence of the activation of adenosine A1 receptors." | 1.29 | Indomethacin modulates ischemia-evoked release of glutamate and adenosine from the rat cerebral cortex. ( O'Regan, MH; Perkins, LM; Phillis, JW; Smith-Barbour, M, 1994) |
| "Muscimol was infused into the third ventricle continuously for 7 days beginning just prior to the insult." | 1.29 | GABA agonist "muscimol" is neuroprotective in repetitive transient forebrain ischemia in gerbils. ( Ijaz, S; Mazagri, R; Shuaib, A, 1993) |
| "A former study indicated that hypoxic-ischemic encephalopathy in rat sustained during early postnatal life may result in permanent epileptic activity in the baseline electroencephalogram." | 1.29 | Permanent increase of immunocytochemical reactivity for gamma-aminobutyric acid (GABA), glutamic acid decarboxylase, mitochondrial enzymes, and glial fibrillary acidic protein in rat cerebral cortex damaged by early postnatal hypoxia-ischemia. ( Janszen, AW; Romijn, HJ; Van den Bogert, C, 1994) |
| "A cardiac arrest was induced with intravenous KCl, and the times until electroencephalograph isoelectricity and terminal depolarization were recorded." | 1.29 | Effects of hypothermia on the rate of excitatory amino acid release after ischemic depolarization. ( Nakashima, K; Todd, MM, 1996) |
| "Susceptibility to audiogenic seizures (AGS) was investigated in Sprague-Dawley rats subjected to cardiac arrest cerebral ischemia (CACI), produced by compression of the major cardiac vessels." | 1.29 | Development of susceptibility to audiogenic seizures following cardiac arrest cerebral ischemia in rats. ( Kawahara, N; Kawai, K; Klatzo, I; Penix, LP; Ruetzler, CA, 1995) |
| "Repetitive cerebral ischemia in gerbils produces delayed neuronal damage in the substantia nigra reticulata (SNr)." | 1.29 | Progressive decrease in extracellular GABA concentrations in the post-ischemic period in the striatum: a microdialysis study. ( Ijaz, S; Kanthan, R; Mainprize, T; Miyashita, H; Shuaib, A, 1994) |
| "Glycine levels were significantly depressed, both pre- and post-ischemia, in cortical superfusates from hypothermic animals in comparison with normothermic rats." | 1.28 | The effects of hypothermia on amino acid neurotransmitter release from the cerebral cortex. ( Phillis, JW; Simpson, RE; Walter, GA, 1991) |
| "The amnesia was estimated by the response latency for a rat to step from a light safety compartment to a dark compartment in which a foot-shock was given." | 1.27 | Beneficial effect of idebenone (CV-2619) on cerebral ischemia-induced amnesia in rats. ( Nagaoka, A; Nagawa, Y; Take, Y; Yamazaki, N, 1984) |
| "The effect of anoxia and ischemia on the release of amino acid transmitters from cerebellar slices induced by veratridine or high [K+] was studied." | 1.27 | Effects of anoxia on the stimulated release of amino acid neurotransmitters in the cerebellum in vitro. ( Balázs, R; Bosley, TM; Gordon, RD; Woodhams, PL, 1983) |
| "Brain ischemia was induced for 10 or 30 min by clamping the common carotid arteries in rabbits whose vertebral arteries had previously been electrocauterized." | 1.27 | Ischemia-induced shift of inhibitory and excitatory amino acids from intra- to extracellular compartments. ( Hagberg, H; Hamberger, A; Jacobson, I; Lehmann, A; Nyström, B; Sandberg, M, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (12.56) | 18.7374 |
| 1990's | 68 (32.85) | 18.2507 |
| 2000's | 58 (28.02) | 29.6817 |
| 2010's | 42 (20.29) | 24.3611 |
| 2020's | 13 (6.28) | 2.80 |
| Authors | Studies |
|---|---|
| Balakrishnan, K | 1 |
| Hleihil, M | 1 |
| Bhat, MA | 1 |
| Ganley, RP | 1 |
| Vaas, M | 1 |
| Klohs, J | 1 |
| Zeilhofer, HU | 1 |
| Benke, D | 1 |
| Lu, Y | 2 |
| Li, CJ | 1 |
| Li, WJ | 1 |
| Zhou, M | 1 |
| Liu, L | 2 |
| Liu, BH | 1 |
| Pu, J | 1 |
| Li, ZQ | 1 |
| Zhang, XR | 1 |
| Li, JW | 1 |
| Hu, YC | 1 |
| Wang, YY | 1 |
| Mei, JJ | 1 |
| Gao, J | 1 |
| Ren, BB | 1 |
| Feng, XD | 1 |
| Li, RQ | 1 |
| Mohammed, RA | 1 |
| Sayed, RH | 1 |
| El-Sahar, AE | 1 |
| Khattab, MA | 1 |
| Saad, MA | 2 |
| Zakharov, VV | 1 |
| Borodulina, IV | 1 |
| Vakhnina, NV | 1 |
| Monov, D | 1 |
| Pashanova, O | 1 |
| Zhu, Z | 1 |
| Yang, P | 1 |
| Jia, Y | 1 |
| Wang, Y | 3 |
| Shi, M | 1 |
| Zhong, C | 1 |
| Peng, H | 1 |
| Sun, L | 1 |
| Guo, D | 1 |
| Xu, Q | 1 |
| Chen, J | 1 |
| Wang, A | 1 |
| Xu, T | 1 |
| He, J | 1 |
| Zhang, Y | 3 |
| Feng, YW | 1 |
| Huang, YQ | 1 |
| Yan, Y | 1 |
| Li, G | 2 |
| He, XF | 1 |
| Liang, FY | 1 |
| Pei, Z | 1 |
| Lan, Y | 1 |
| Xu, GQ | 1 |
| Chabriat, H | 1 |
| Bassetti, CL | 1 |
| Marx, U | 1 |
| Audoli-Inthavong, ML | 1 |
| Sors, A | 1 |
| Lambert, E | 1 |
| Wattez, M | 1 |
| Hermann, DM | 1 |
| Wang, JX | 1 |
| Mu, JD | 1 |
| Ma, LX | 1 |
| Sun, TY | 1 |
| Qian, X | 1 |
| Yu, WY | 1 |
| Tian, Y | 2 |
| Song, Y | 2 |
| Gan, YY | 1 |
| Guo, MW | 1 |
| Ren, XX | 1 |
| Li, JL | 1 |
| Li, J | 3 |
| Chen, L | 2 |
| Guo, F | 2 |
| Han, X | 1 |
| Song, D | 5 |
| Chen, Y | 1 |
| Chen, C | 1 |
| Cheng, O | 1 |
| Huang, L | 2 |
| Wang, C | 1 |
| Ge, R | 1 |
| Ni, H | 1 |
| Zhao, S | 1 |
| Lin, S | 1 |
| Zhou, G | 1 |
| Shao, W | 1 |
| Fu, Z | 2 |
| Jiang, L | 1 |
| Li, W | 1 |
| Mamtilahun, M | 1 |
| Ma, Y | 1 |
| Qu, M | 1 |
| He, X | 1 |
| Zheng, J | 1 |
| Zhang, Z | 2 |
| Yang, GY | 1 |
| Mayor, D | 1 |
| Tymianski, M | 1 |
| Orfila, JE | 1 |
| Grewal, H | 1 |
| Dietz, RM | 1 |
| Strnad, F | 1 |
| Shimizu, T | 1 |
| Moreno, M | 1 |
| Schroeder, C | 1 |
| Yonchek, J | 1 |
| Rodgers, KM | 1 |
| Dingman, A | 1 |
| Bernard, TJ | 1 |
| Quillinan, N | 1 |
| Macklin, WB | 1 |
| Traystman, RJ | 1 |
| Herson, PS | 1 |
| Zhang, M | 1 |
| Sun, X | 1 |
| Gong, Y | 1 |
| Xu, L | 1 |
| Volotova, EV | 2 |
| Filina, IS | 1 |
| Bakulin, DA | 1 |
| Kurkin, DV | 2 |
| Tyurenkov, IN | 1 |
| Zhang, W | 1 |
| Wang, L | 1 |
| Pang, X | 1 |
| Zhang, J | 2 |
| Guan, Y | 1 |
| Liu, J | 1 |
| Wu, YY | 1 |
| Yu, XL | 1 |
| Jia, HY | 1 |
| Mao, QY | 1 |
| Fang, JQ | 1 |
| Belozertsev, IuA | 1 |
| Zapol'skaia, IuA | 1 |
| Belozertsev, FIu | 1 |
| Iuntsev, SV | 1 |
| Russ, JB | 1 |
| Verina, T | 1 |
| Comer, JD | 1 |
| Comi, AM | 2 |
| Kaltschmidt, JA | 1 |
| Gorbunova, AV | 1 |
| Gan'shina, TS | 2 |
| Gretskaia, NM | 2 |
| Bezuglov, VV | 3 |
| Mirzoian, RS | 2 |
| Han, J | 1 |
| Wan, HT | 1 |
| Yang, JH | 1 |
| Zhang, YY | 1 |
| Ge, LJ | 1 |
| Bie, XD | 1 |
| Berthet, C | 2 |
| Xin, L | 1 |
| Buscemi, L | 1 |
| Benakis, C | 1 |
| Gruetter, R | 2 |
| Hirt, L | 2 |
| Lei, H | 2 |
| Shao, B | 1 |
| Zhou, YL | 1 |
| Wang, H | 4 |
| Lin, YS | 1 |
| Abdelsalam, RM | 1 |
| Kenawy, SA | 1 |
| Attia, AS | 1 |
| Kurzepa, J | 1 |
| Szpetnar, M | 1 |
| Hordyjewska, A | 1 |
| Wątroba, S | 1 |
| Gołąb, P | 1 |
| Boguszewska-Czubara, A | 1 |
| Duan, CL | 1 |
| Liu, CW | 1 |
| Shen, SW | 1 |
| Yu, Z | 1 |
| Mo, JL | 1 |
| Chen, XH | 1 |
| Sun, FY | 1 |
| Safonova, OA | 1 |
| Popova, TN | 1 |
| Slivkin, AI | 1 |
| Talmi, Y | 1 |
| Mirzoyan, NR | 1 |
| Hostikyan, NG | 1 |
| Stepanyan, AG | 1 |
| Akopyan, AA | 1 |
| Alikhanyan, KB | 1 |
| Meliksetyan, VS | 1 |
| Bagdasaryan, NA | 1 |
| Gretskaya, NM | 1 |
| Long, Q | 1 |
| Hei, Y | 1 |
| Luo, Q | 1 |
| Yang, J | 1 |
| Wei, L | 1 |
| Liu, W | 1 |
| Matsuura, W | 1 |
| Harada, S | 1 |
| Tokuyama, S | 1 |
| Ramanathan, M | 1 |
| Abdul, KK | 1 |
| Justin, A | 1 |
| Nielsen, M | 1 |
| Zimmer, J | 1 |
| Diemer, NH | 3 |
| Kumar, M | 1 |
| Tyagi, N | 1 |
| Moshal, KS | 1 |
| Sen, U | 1 |
| Kundu, S | 1 |
| Mishra, PK | 1 |
| Givvimani, S | 1 |
| Tyagi, SC | 1 |
| Benveniste, H | 1 |
| Jia, J | 1 |
| Hu, YS | 1 |
| Wu, Y | 1 |
| Liu, G | 1 |
| Yu, HX | 1 |
| Zheng, QP | 1 |
| Zhu, DN | 1 |
| Xia, CM | 1 |
| Cao, ZJ | 1 |
| Oja, SS | 10 |
| Saransaari, P | 10 |
| Ohira, K | 1 |
| Furuta, T | 1 |
| Hioki, H | 1 |
| Nakamura, KC | 1 |
| Kuramoto, E | 1 |
| Tanaka, Y | 1 |
| Funatsu, N | 1 |
| Shimizu, K | 1 |
| Oishi, T | 1 |
| Hayashi, M | 1 |
| Miyakawa, T | 1 |
| Kaneko, T | 1 |
| Nakamura, S | 1 |
| Fishell, G | 1 |
| Goldman, JE | 1 |
| Qi, SH | 1 |
| Liu, Y | 1 |
| Hao, LY | 1 |
| Guan, QH | 1 |
| Gu, YH | 1 |
| Yan, H | 1 |
| Wang, M | 1 |
| Zhang, GY | 1 |
| Brady, JD | 1 |
| Mohr, C | 1 |
| Rossi, DJ | 2 |
| Chen, N | 1 |
| Ge, M | 1 |
| Zhu, Y | 1 |
| Guan, S | 1 |
| Wang, JH | 1 |
| Luccini, E | 1 |
| Romei, C | 1 |
| Di Prisco, S | 1 |
| Raiteri, M | 2 |
| Raiteri, L | 1 |
| Kreuzberg, M | 1 |
| Kanov, E | 1 |
| Timofeev, O | 1 |
| Schwaninger, M | 1 |
| Monyer, H | 1 |
| Khodosevich, K | 1 |
| Chi, OZ | 1 |
| Hunter, C | 1 |
| Liu, X | 1 |
| Chi, Y | 1 |
| Weiss, HR | 1 |
| Zhang, S | 2 |
| Yang, Z | 1 |
| Sun, Z | 1 |
| Gomes, JR | 1 |
| Lobo, AC | 1 |
| Melo, CV | 1 |
| Inácio, AR | 1 |
| Takano, J | 1 |
| Iwata, N | 2 |
| Saido, TC | 1 |
| de Almeida, LP | 1 |
| Wieloch, T | 2 |
| Duarte, CB | 1 |
| Hoffmann, U | 1 |
| Lee, JH | 1 |
| Qin, T | 1 |
| Eikermann-Haerter, K | 1 |
| Ayata, C | 1 |
| Yang, ZZ | 1 |
| Li, SX | 1 |
| Feng, W | 1 |
| Xu, X | 2 |
| Chang, M | 1 |
| Zhang, C | 1 |
| Sun, F | 1 |
| Ricci, L | 1 |
| Valoti, M | 1 |
| Sgaragli, G | 1 |
| Frosini, M | 1 |
| Alf, MF | 1 |
| Mlynarik, V | 1 |
| Vlasov, TD | 1 |
| Chefu, SG | 1 |
| Baĭsa, AE | 1 |
| Leko, MV | 1 |
| Burov, SV | 1 |
| Veselkina, OS | 1 |
| Gnezdilova, AV | 1 |
| Maslennikov, DV | 1 |
| Tiurenkov, IN | 1 |
| Litvinov, AA | 1 |
| Tarasov, AS | 1 |
| Pamenter, ME | 1 |
| Hogg, DW | 1 |
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| Haddad, GG | 1 |
| Allen, NJ | 3 |
| Attwell, D | 3 |
| Cozzi, A | 1 |
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| Carlà, V | 1 |
| Pellicciari, R | 1 |
| Moroni, F | 1 |
| Pellegrini-Giampietro, DE | 1 |
| Fu, JH | 1 |
| Du, GY | 2 |
| Qureshi, AI | 1 |
| Ali, Z | 1 |
| Suri, MF | 1 |
| Shuaib, A | 8 |
| Baker, G | 1 |
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| Koehler, RC | 1 |
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| Murphy, SJ | 1 |
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| Lange-Asschenfeldt, C | 1 |
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| Jansen, JA | 1 |
| Ijaz, MS | 2 |
| Waqar, T | 1 |
| Voll, C | 1 |
| Kanthan, R | 5 |
| Miyashita, H | 5 |
| Griebel, R | 1 |
| O'Regan, MH | 9 |
| Smith-Barbour, M | 4 |
| Perkins, LM | 4 |
| Phillis, JW | 10 |
| Kawai, K | 1 |
| Penix, LP | 1 |
| Kawahara, N | 1 |
| Ruetzler, CA | 1 |
| Ijaz, S | 2 |
| Mainprize, T | 1 |
| Djuricic, B | 1 |
| Berger, R | 1 |
| Paschen, W | 1 |
| Lyden, PD | 1 |
| Lonzo, L | 1 |
| Gajkowska, B | 1 |
| Mossakowski, MJ | 1 |
| van Zijl, PC | 1 |
| Moonen, CT | 1 |
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| Swan, JH | 1 |
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| Tan, WK | 1 |
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| Patel, TR | 1 |
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| McCulloch, J | 1 |
| Cataltepe, O | 1 |
| Towfighi, J | 1 |
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| Panah, M | 2 |
| Kiffel, S | 1 |
| Haugstad, TS | 1 |
| Karlsen, HE | 1 |
| Krajtci, P | 1 |
| Due-Tønnessen, B | 1 |
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| Brandtzaeg, P | 1 |
| Langmoen, IA | 1 |
| Hussain, S | 1 |
| Kokaia, Z | 1 |
| Andsberg, G | 1 |
| Martinez-Serrano, A | 1 |
| Lindvall, O | 1 |
| Pascual, JM | 1 |
| Carceller, F | 1 |
| Roda, JM | 1 |
| Cerdán, S | 1 |
| Nonaka, M | 1 |
| Yoshimine, T | 1 |
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| Wakayama, A | 1 |
| Yamashita, T | 1 |
| Hayakawa, T | 1 |
| Neumann-Haefelin, T | 1 |
| Staiger, JF | 1 |
| Redecker, C | 1 |
| Zilles, K | 1 |
| Fritschy, JM | 1 |
| Möhler, H | 1 |
| Goda, H | 1 |
| Ooboshi, H | 2 |
| Nakane, H | 1 |
| Ibayashi, S | 2 |
| Sadoshima, S | 2 |
| Fujishima, M | 2 |
| Shimizu-Sasamata, M | 2 |
| Bosque-Hamilton, P | 1 |
| Huang, PL | 2 |
| Moskowitz, MA | 2 |
| Lo, EH | 2 |
| Skvortsova, VI | 1 |
| Raevskiĭ, KS | 1 |
| Kovalenko, AV | 1 |
| Kudrin, VS | 1 |
| Malikova, LA | 1 |
| Sokolov, MA | 1 |
| Alekseev, AA | 1 |
| Gusev, EI | 1 |
| Li, PA | 1 |
| He, QP | 1 |
| Howllet, W | 1 |
| Siesjö, BK | 1 |
| Liu, GQ | 1 |
| Liu, XD | 1 |
| Xiao, XQ | 1 |
| Melani, A | 1 |
| Pantoni, L | 1 |
| Corsi, C | 1 |
| Bianchi, L | 1 |
| Monopoli, A | 1 |
| Bertorelli, R | 1 |
| Pepeu, G | 1 |
| Pedata, F | 1 |
| Guyot, LL | 3 |
| Diaz, FG | 3 |
| Green, AR | 3 |
| Hainsworth, AH | 3 |
| Jackson, DM | 1 |
| Nelson, RM | 2 |
| Lambert, DG | 2 |
| D'Alessandro, G | 1 |
| Corso, G | 1 |
| Bottacchi, E | 1 |
| Takano, K | 1 |
| Kondo, A | 1 |
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| Weihe, E | 1 |
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| Nakamura, T | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Efficacy and Safety Trial With Oral S 44819 After Recent Ischemic Cerebral Event. International, Multi-centre, Randomized, Doubleblind Placebo-controlled Phase II Study. (RESTORE BRAIN Study)[NCT02877615] | Phase 2 | 585 participants (Actual) | Interventional | 2016-12-19 | Completed | ||
| Brain Changes in Pediatric Obstructive Sleep Apnea[NCT05368077] | 70 participants (Anticipated) | Interventional | 2022-05-14 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
17 reviews available for gamma-aminobutyric acid and Brain Ischemia
| Article | Year |
|---|---|
The Effects of GABAergic System under Cerebral Ischemia: Spotlight on Cognitive Function.
Topics: Animals; Brain Ischemia; Cognition; Cognitive Dysfunction; gamma-Aminobutyric Acid; Hippocampus; Hum | 2020 |
Neurotransmitters in the mediation of cerebral ischemic injury.
Topics: Animals; Brain Ischemia; Calcium; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Receptors, GABA; R | 2018 |
[Neuroprotection in brain ischemia--doubts and hopes].
Topics: Animals; Apoptosis; Brain Ischemia; Calcium Channels; Cerebrovascular Circulation; Clinical Trials a | 2004 |
Functional pharmacology in human brain.
Topics: Acetylcholine; Alzheimer Disease; Brain; Brain Ischemia; Epilepsy; gamma-Aminobutyric Acid; Glutamic | 2006 |
Anesthetic-mediated protection/preconditioning during cerebral ischemia.
Topics: Anesthetics, Inhalation; Animals; Brain; Brain Ischemia; Disease Models, Animal; gamma-Aminobutyric | 2007 |
GABA release under normal and ischemic conditions.
Topics: Animals; Brain Ischemia; gamma-Aminobutyric Acid; Humans; Nitric Oxide; Receptors, Glutamate; Second | 2008 |
A review of the preclinical pharmacology of tiagabine: a potent and selective anticonvulsant GABA uptake inhibitor.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain Ischemia; Dogs; gamma-Aminobutyric Acid; Humans; I | 1995 |
Interneurons in rat hippocampus after cerebral ischemia. Morphometric, functional, and therapeutic investigations.
Topics: Animals; Autoradiography; Brain Ischemia; Calcium-Binding Proteins; Cell Death; Cholecystokinin; Dis | 1993 |
Amplification of inhibitory mechanisms in cerebral ischemia: an alternative approach to neuronal protection.
Topics: Adenosine; Animals; Brain Ischemia; Calcium Channels; gamma-Aminobutyric Acid; Humans; Hypothermia, | 1997 |
Neuronal and endothelial nitric oxide synthase gene knockout mice.
Topics: Animals; Brain; Brain Ischemia; Cyclic GMP; Endothelium, Vascular; gamma-Aminobutyric Acid; Glutamic | 1999 |
GABA potentiation: a logical pharmacological approach for the treatment of acute ischaemic stroke.
Topics: Acute Disease; Animals; Brain; Brain Ischemia; Chlormethiazole; GABA Agonists; gamma-Aminobutyric Ac | 2000 |
An overview of acute stroke therapy: past, present, and future.
Topics: Acute Disease; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antibodies; Brain Ischemia; | 2000 |
gamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia.
Topics: Adenosine Triphosphate; Adult; Age Factors; Allosteric Regulation; Animals; Apoptosis; Arachidonic A | 2001 |
[Cerebral metabolic activator (author's transl)].
Topics: Adenosine Triphosphate; Animals; Barbiturates; Biogenic Amines; Biotransformation; Brain; Brain Isch | 1979 |
Cyclic nucleotides in stroke and related cerebrovascular disorders.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenosine; Adenylyl Cyclas | 1985 |
Neurochemical correlates to selective neuronal vulnerability.
Topics: Adenosine; Afferent Pathways; Animals; Aspartic Acid; Brain Diseases; Brain Ischemia; Calcium; Chlor | 1985 |
Etiologic and preventive aspects of epilepsy in the child--bridging the gap between laboratory and clinic.
Topics: Barbiturates; Brain; Brain Ischemia; Child; Child, Preschool; Epilepsy; Female; Fetal Diseases; gamm | 1987 |
3 trials available for gamma-aminobutyric acid and Brain Ischemia
| Article | Year |
|---|---|
[Treatment of patients with chronic cerebral ischemia: experience of using the combined neuroprotective drug Picamilon Ginkgo].
Topics: Brain Ischemia; gamma-Aminobutyric Acid; Ginkgo biloba; Humans; Neuroprotective Agents; Phytotherapy | 2022 |
Plasma Amino Acid Neurotransmitters and Ischemic Stroke Prognosis: A Multicenter Prospective Study.
Topics: Aspartic Acid; Biomarkers; Brain Ischemia; Cohort Studies; gamma-Aminobutyric Acid; Glutamic Acid; G | 2023 |
Safety and efficacy of GABA
Topics: Adult; Aged; Aged, 80 and over; Benzodiazepines; Brain; Brain Ischemia; Double-Blind Method; Female; | 2020 |
187 other studies available for gamma-aminobutyric acid and Brain Ischemia
| Article | Year |
|---|---|
Targeting the interaction of GABA
Topics: Animals; Brain; Brain Ischemia; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cerebral Infarct | 2023 |
Depressive-like behaviors induced by chronic cerebral hypoperfusion associate with a dynamic change of GABA
Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; gamma-Aminobutyric Acid; Hippocampus; Rats; Rats, | 2022 |
The effects of hypothermia on glutamate and γ-aminobutyric acid metabolism during ischemia in monkeys: a repeated-measures ANOVA study.
Topics: Amino Acids; Analysis of Variance; Animals; Brain Ischemia; gamma-Aminobutyric Acid; Glutamic Acid; | 2022 |
[Effect of electroacupuncture of Governor Vessel on expression of GAD67 and GABA-T in cerebral cortex of rats with post-stroke limb spasticity].
Topics: Animals; Brain Ischemia; Cerebral Cortex; Electroacupuncture; gamma-Aminobutyric Acid; Glutamate Dec | 2022 |
Insights into the role of pERK1/2 signaling in post-cerebral ischemia reperfusion sexual dysfunction in rats.
Topics: Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cerebral Infarction; gamma-Aminobutyric | 2022 |
Experimental Substantiation of the Use of Phenibut Combinations with Salicylic, Nicotinic, and Glutamic Acids in Cerebral Ischemia.
Topics: Animals; Brain Ischemia; Cerebral Infarction; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Male; | 2023 |
Phasic GABA signaling mediates the protective effects of cTBS against cerebral ischemia in mice.
Topics: Animals; Brain Ischemia; Electric Stimulation Therapy; GABAergic Neurons; gamma-Aminobutyric Acid; I | 2020 |
Waggle needling wields preferable neuroprotective and anti-spastic effects on post-stroke spasticity rats by attenuating γ-aminobutyric acid transaminase and enhancing γ-aminobutyric acid.
Topics: 4-Aminobutyrate Transaminase; Acupuncture Therapy; Animals; Brain Ischemia; gamma-Aminobutyric Acid; | 2020 |
GABA
Topics: Animals; Brain Ischemia; Cognition; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampu | 2021 |
Ischemia deteriorates spike encoding at cortical GABAergic neurons and cerebellar Purkinje cells by increasing the intracellular Ca
Topics: Action Potentials; Animals; Brain; Brain Ischemia; Calcium; Cerebral Cortex; Cytoplasm; GABAergic Ne | 2017 |
Impact of dexmedetomidine on amino acid contents and the cerebral ultrastructure of rats with cerebral ischemia-reperfusion injury.
Topics: Amino Acids; Animals; Brain Ischemia; Cerebral Cortex; Dexmedetomidine; gamma-Aminobutyric Acid; Glu | 2017 |
Optogenetic Inhibition of Striatal GABAergic Neuronal Activity Improves Outcomes After Ischemic Brain Injury.
Topics: Animals; Brain Ischemia; Corpus Striatum; Endothelial Cells; Fibroblast Growth Factor 2; GABA Antago | 2017 |
Delayed inhibition of tonic inhibition enhances functional recovery following experimental ischemic stroke.
Topics: Animals; Brain Ischemia; Cognition; gamma-Aminobutyric Acid; Hippocampus; Long-Term Potentiation; Ma | 2019 |
[Ghrelin protects against hippocampal injury after global cerebral ischemia/reperfusion and regulate glutamic acid/γ-aminobutyric acid sensitive neuron discharge]
Topics: Animals; Brain; Brain Ischemia; Cerebral Infarction; gamma-Aminobutyric Acid; Ghrelin; Glutamic Acid | 2016 |
NEUROPROTECTIVE ACTION OF PHENIBUT AND NEUROGLUTAM IN EXPERIMENTAL CEREBRAL ISCHEMIA ON THE BACKGROUND OF ALTERED IMMUNOREACTIVITY.
Topics: Animals; Animals, Outbred Strains; Biomarkers; Brain Ischemia; Carotid Artery, Common; Cerebrovascul | 2016 |
Role of microRNA-155 in modifying neuroinflammation and γ-aminobutyric acid transporters in specific central regions after post-ischaemic seizures.
Topics: Amygdala; Animals; Brain Ischemia; Disease Models, Animal; Epilepsy; GABA Plasma Membrane Transport | 2019 |
Temporal effect of acupuncture on amino acid neurotransmitters in rats with acute cerebral ischaemia.
Topics: Acupuncture Therapy; Animals; Brain Ischemia; Disease Models, Animal; gamma-Aminobutyric Acid; Gluta | 2019 |
[Comparison of neuroprotective effects of anticonvulsant drugs in brain injury therapy].
Topics: Amines; Animals; Animals, Outbred Strains; Anticonvulsants; Brain; Brain Injuries; Brain Ischemia; C | 2012 |
Corticospinal tract insult alters GABAergic circuitry in the mammalian spinal cord.
Topics: Animals; Brain Ischemia; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Interneurons; Mice; Pyram | 2013 |
[Cerebrovascular effects of GABA-prostaglandin E2 conjugate in comparison with prostaglandin E2].
Topics: Animals; Bicuculline; Brain Ischemia; Cerebrovascular Circulation; Dinoprostone; GABA-A Receptor Ant | 2013 |
Effect of ligustrazine on levels of amino acid neurotransmitters in rat striatum after cerebral ischemia-reperfusion injury.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Corpus Striatum; gamma-Aminobutyric Acid | 2014 |
Non-invasive diagnostic biomarkers for estimating the onset time of permanent cerebral ischemia.
Topics: Animals; Biomarkers; Brain Ischemia; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamine; Hum | 2014 |
The role of calcitonin gene-related peptide in post-stroke depression in chronic mild stress-treated ischemic rats.
Topics: Anhedonia; Animals; Antidepressive Agents; Brain Ischemia; Calcitonin Gene-Related Peptide; Chronic | 2015 |
Ischemic preconditioning and postconditioning alleviates hippocampal tissue damage through abrogation of apoptosis modulated by oxidative stress and inflammation during transient global cerebral ischemia-reperfusion in rats.
Topics: Animals; Apoptosis; Biomarkers; Brain Ischemia; Encephalitis; gamma-Aminobutyric Acid; Glutamic Acid | 2015 |
Thrombolytic treatment decreases glutamate/GABA ratio in serum during acute ischaemic stroke: a pilot study.
Topics: Aged; Aged, 80 and over; Brain Ischemia; Female; Fibrinolytic Agents; gamma-Aminobutyric Acid; Gluta | 2015 |
Striatal astrocytes transdifferentiate into functional mature neurons following ischemic brain injury.
Topics: Animals; Astrocytes; Brain Ischemia; Choline O-Acetyltransferase; Corpus Striatum; Disease Models, A | 2015 |
Effects of a Preparation Containing Pantogam, Succinic Acid, and Chitosan on Activities of the Glutathione System and NADPH-Generating Enzymes in Rat Tissues under Conditions of Cerebral Ischemia/Reperfusion.
Topics: Animals; Brain Ischemia; Chitosan; Drug Combinations; Free Radicals; gamma-Aminobutyric Acid; Glucos | 2015 |
[STUDYING NEUROPROTECTIVE ACTIVITY OF GABA CONJUGATE WITH ARACHIDONIC ACID UNDER CONDITIONS OF LOCAL PERMANENT BRAIN ISCHEMIA IN RATS].
Topics: Animals; Arachidonic Acids; Brain Ischemia; Disease Models, Animal; GABA Agents; gamma-Aminobutyric | 2015 |
BMSCs transplantation improves cognitive impairment via up-regulation of hippocampal GABAergic system in a rat model of chronic cerebral hypoperfusion.
Topics: Animals; Bone Marrow Transplantation; Brain Ischemia; Carotid Artery Diseases; Cell Movement; Chroni | 2015 |
Effects of Adjuvant Analgesics on Cerebral Ischemia-Induced Mechanical Allodynia.
Topics: Amines; Analgesics; Animals; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Antico | 2016 |
Low dose of L-glutamic acid attenuated the neurological dysfunctions and excitotoxicity in bilateral common carotid artery occluded mice.
Topics: Animals; Brain; Brain Ischemia; Carotid Artery, Common; Disease Models, Animal; Dose-Response Relati | 2016 |
Endonuclease G expression in thalamic reticular nucleus after global cerebral ischemia.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Astrocytes; Biomarkers; Brain Infarction; Brain | 2008 |
Homocysteine decreases blood flow to the brain due to vascular resistance in carotid artery.
Topics: Animals; Brain Ischemia; Carotid Arteries; Cerebrovascular Circulation; Collagen; Collagen Type III; | 2008 |
Glutamate, microdialysis, and cerebral ischemia: lost in translation?
Topics: Amino Acids; Animals; Brain Ischemia; gamma-Aminobutyric Acid; Glutamic Acid; Microdialysis; N-Methy | 2009 |
Pre-ischemic treadmill training affects glutamate and gamma aminobutyric acid levels in the striatal dialysate of a rat model of cerebral ischemia.
Topics: Animals; Brain Ischemia; Corpus Striatum; Disease Models, Animal; Exercise Test; gamma-Aminobutyric | 2009 |
Release of endogenous amino acids from the hippocampus and brain stem from developing and adult mice in ischemia.
Topics: Aging; Alanine; Animals; Aspartic Acid; Brain Ischemia; Brain Stem; Female; gamma-Aminobutyric Acid; | 2009 |
Ischemia-induced neurogenesis of neocortical layer 1 progenitor cells.
Topics: Adult Stem Cells; Animals; Brain Ischemia; Cell Proliferation; gamma-Aminobutyric Acid; Male; Neurog | 2010 |
A silver lining to stroke: does ischemia generate new cortical interneurons?
Topics: Adult Stem Cells; Animals; Brain Ischemia; Cell Cycle; Cell Movement; Cell Proliferation; Cerebral C | 2010 |
Neuroprotection of ethanol against ischemia/reperfusion-induced brain injury through decreasing c-Jun N-terminal kinase 3 (JNK3) activation by enhancing GABA release.
Topics: Animals; Apoptosis; Bicuculline; Brain Ischemia; CA1 Region, Hippocampal; Cadmium Chloride; Calcium | 2010 |
Vesicular GABA release delays the onset of the Purkinje cell terminal depolarization without affecting tissue swelling in cerebellar slices during simulated ischemia.
Topics: Animals; Brain Edema; Brain Ischemia; Cerebellum; Excitatory Postsynaptic Potentials; GABA-A Recepto | 2010 |
Ca2+ and acidosis synergistically lead to the dysfunction of cortical GABAergic neurons during ischemia.
Topics: Acidosis; Animals; Apoptosis; Brain Ischemia; Calcium; gamma-Aminobutyric Acid; Mice; Mice, Inbred S | 2010 |
Ionic dysregulations typical of ischemia provoke release of glycine and GABA by multiple mechanisms.
Topics: Animals; Brain Ischemia; Exocytosis; gamma-Aminobutyric Acid; Glycine; Hippocampus; Mice; Mitochondr | 2010 |
Increased subventricular zone-derived cortical neurogenesis after ischemic lesion.
Topics: Animals; Antimetabolites; Apoptosis; Brain Ischemia; Bromodeoxyuridine; Calbindin 2; Caspase 3; Cere | 2010 |
Effects of GABA(A) receptor blockade on regional cerebral blood flow and blood-brain barrier disruption in focal cerebral ischemia.
Topics: Aminoisobutyric Acids; Animals; Antipyrine; Bicuculline; Blood-Brain Barrier; Brain Ischemia; Carbon | 2011 |
Cortical GABAergic neurons and cerebellar Purkinje cells respond to ischemia-pathogenic factors differently.
Topics: Animals; Brain Ischemia; Cerebellar Cortex; Cerebral Cortex; gamma-Aminobutyric Acid; Interneurons; | 2011 |
Cleavage of the vesicular GABA transporter under excitotoxic conditions is followed by accumulation of the truncated transporter in nonsynaptic sites.
Topics: Animals; Blotting, Western; Brain Ischemia; Calpain; DNA; Excitatory Amino Acid Agonists; Female; ga | 2011 |
Gabapentin reduces infarct volume but does not suppress peri-infarct depolarizations.
Topics: Amines; Animals; Anticonvulsants; Brain; Brain Infarction; Brain Ischemia; Cortical Spreading Depres | 2011 |
Effect of ginkgolide B on striatal extracellular amino acids in middle cerebral artery occluded rats.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Corpus Striatum; gamma-Aminobutyric Acid; Ginkg | 2011 |
Acupuncture to point Baihui prevents ischemia-induced functional impairment of cortical GABAergic neurons.
Topics: Action Potentials; Acupuncture Points; Animals; Brain Ischemia; Cerebral Cortex; Disease Models, Ani | 2011 |
Taurine-like GABA aminotransferase inhibitors prevent rabbit brain slices against oxygen-glucose deprivation-induced damage.
Topics: 4-Aminobutyrate Transaminase; Animals; Brain; Brain Ischemia; gamma-Aminobutyric Acid; Glucose; Male | 2012 |
High-resolution spatial mapping of changes in the neurochemical profile after focal ischemia in mice.
Topics: Animals; Aspartic Acid; Brain Ischemia; gamma-Aminobutyric Acid; Glutamic Acid; Glutathione; Infarct | 2012 |
[Amides of creatine: perspectives of neuroprotection].
Topics: Amides; Animals; Brain Ischemia; Creatine; Female; gamma-Aminobutyric Acid; Glycine; Hemodynamics; I | 2011 |
[Cerebrovascular effects of GABA conjugate with arachidonic acid under conditions of separate and combined vascular pathology of brain and heart].
Topics: Animals; Arachidonic Acid; Blood Pressure; Brain; Brain Ischemia; Carotid Artery, Common; Cerebrovas | 2011 |
[Effect of phenibut and its composition with nicotinic acid on hemostasis in rats with brain ischemia].
Topics: Animals; Anticonvulsants; Brain Ischemia; gamma-Aminobutyric Acid; Hemostasis; Male; Niacin; Rats; R | 2012 |
Painted turtle cortex is resistant to an in vitro mimic of the ischemic mammalian penumbra.
Topics: Action Potentials; Animals; Brain Ischemia; Cell Survival; Cerebral Cortex; Cerebrovascular Circulat | 2012 |
Modulation of ASIC channels in rat cerebellar Purkinje neurons by ischaemia-related signals.
Topics: Acid Sensing Ion Channels; Acidosis; Animals; Arachidonic Acid; Brain Ischemia; Cations; gamma-Amino | 2002 |
Metabotropic glutamate 1 (mGlu1) receptor antagonists enhance GABAergic neurotransmission: a mechanism for the attenuation of post-ischemic injury and epileptiform activity?
Topics: Animals; Brain Ischemia; Cerebral Cortex; Epilepsy; Excitatory Amino Acid Antagonists; gamma-Aminobu | 2002 |
[Effect of tianma cuzhi keli (TMCZKL) on contents of transmitter amino acids of brain tissue in the mouse repetitious cerebral ischemia reperfusion].
Topics: Animals; Aspartic Acid; Brain Ischemia; Cerebral Cortex; Drug Combinations; Drugs, Chinese Herbal; g | 2001 |
Extracellular glutamate and other amino acids in experimental intracerebral hemorrhage: an in vivo microdialysis study.
Topics: Analysis of Variance; Animals; Asparagine; Aspartic Acid; Brain Ischemia; Cerebral Hemorrhage; Chrom | 2003 |
Coactivation of GABA(A) and GABA(B) receptor results in neuroprotection during in vitro ischemia.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain Ischemia; Carrier Proteins; Cerebral C | 2004 |
Sequential release of GABA by exocytosis and reversed uptake leads to neuronal swelling in simulated ischemia of hippocampal slices.
Topics: Action Potentials; Animals; beta-Alanine; Brain Ischemia; Calcium; Carrier Proteins; Cell Size; Exci | 2004 |
Antiepileptic drug treatment of nonconvulsive seizures induced by experimental focal brain ischemia.
Topics: Amines; Animals; Anticonvulsants; Brain Infarction; Brain Injuries; Brain Ischemia; Cyclohexanecarbo | 2004 |
Metabotropic glutamate receptors modulate ischemia-induced GABA release in mouse hippocampal slices.
Topics: Animals; Animals, Newborn; Brain Ischemia; gamma-Aminobutyric Acid; Glutamates; Hippocampus; In Vitr | 2004 |
GABA neurons survive focal ischemic injury.
Topics: Animals; Brain Ischemia; Cell Survival; Cerebral Cortex; Disease Models, Animal; Down-Regulation; Fu | 2004 |
The effect of simulated ischaemia on spontaneous GABA release in area CA1 of the juvenile rat hippocampus.
Topics: Age Factors; Animals; Brain Ischemia; Cell Hypoxia; gamma-Aminobutyric Acid; Hippocampus; In Vitro T | 2004 |
[Effects of tianma gouteng fang on transmitter amino acids in the hippocampus extracellular liquids in freely moving rats subjected to brain ischemia].
Topics: Animals; Arginine; Brain Ischemia; Drug Combinations; Drugs, Chinese Herbal; Excitatory Amino Acids; | 2004 |
[Effects of L-tetrahydropalmatine on concentrations of neurotransmitter amino acids in mice with cerebral ischemia].
Topics: Animals; Berberine Alkaloids; Brain; Brain Ischemia; Drugs, Chinese Herbal; Female; gamma-Aminobutyr | 2004 |
Failure of ischemic neuroprotection by potentiators of gamma-aminobutyric acid.
Topics: Animals; Anticonvulsants; Brain Ischemia; Disease Models, Animal; Fructose; gamma-Aminobutyric Acid; | 2003 |
Decreased expression of vesicular GABA transporter, but not vesicular glutamate, acetylcholine and monoamine transporters in rat brain following focal ischemia.
Topics: Animals; Brain; Brain Ischemia; Cerebral Cortex; Disease Models, Animal; Down-Regulation; gamma-Amin | 2005 |
Role of GABA in electro-acupuncture therapy on cerebral ischemia induced by occlusion of the middle cerebral artery in rats.
Topics: Animals; Brain Ischemia; Cell Survival; Cerebral Cortex; Dose-Response Relationship, Drug; Electroac | 2005 |
GABA release modified by adenosine receptors in mouse hippocampal slices under normal and ischemic conditions.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor | 2005 |
Estradiol alters only GAD67 mRNA levels in ischemic rat brain with no consequent effects on GABA.
Topics: Animals; Brain Chemistry; Brain Ischemia; Cerebral Cortex; Corpus Striatum; Estradiol; Female; gamma | 2006 |
Ischemic preconditioning ameliorates excitotoxicity by shifting glutamate/gamma-aminobutyric acid release and biosynthesis.
Topics: Animals; Brain Ischemia; Cell Death; Disease Models, Animal; Extracellular Fluid; GABA Agonists; gam | 2005 |
Characteristics of GABA release in mouse brain stem slices under normal and ischemic conditions.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfo | 2005 |
Enhancement of neuroprotection of mulberry leaves (Morus alba L.) prepared by the anaerobic treatment against ischemic damage.
Topics: Anaerobiosis; Animals; Brain Ischemia; Cell Hypoxia; Cell Survival; Cerebral Infarction; gamma-Amino | 2006 |
GABA in ischemic stroke. Proton magnetic resonance study.
Topics: Aged; Aged, 80 and over; Brain Ischemia; Case-Control Studies; Female; gamma-Aminobutyric Acid; Huma | 2004 |
Relevance of astrocytic activation to reductions of astrocytic GABAA receptors.
Topics: Aging; Animals; Animals, Newborn; Astrocytes; Biomarkers; Brain Ischemia; Cell Communication; Cell M | 2006 |
Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats.
Topics: Acute Disease; Amines; Animals; Brain Ischemia; Cyclohexanecarboxylic Acids; Dose-Response Relations | 2006 |
Expression of glutamic acid decarboxylase and identification of GABAergic cells in the ischemic rat dentate gyrus.
Topics: Animals; Biomarkers; Brain Ischemia; Cell Count; Dentate Gyrus; Fluoresceins; gamma-Aminobutyric Aci | 2006 |
Modulation of GABA release by second messenger substances and NO in mouse brain stem slices under normal and ischemic conditions.
Topics: Animals; Brain Ischemia; Brain Stem; Cyclic AMP; Enzyme Activators; Enzyme Inhibitors; Female; GABA | 2006 |
Direct correlation between ischemic injury and extracellular glycine concentration in mice with genetically altered activities of the glycine cleavage multienzyme system.
Topics: Alanine; Amino Acid Oxidoreductases; Animals; Brain Ischemia; Carrier Proteins; Cerebrovascular Circ | 2007 |
Time course of changes in pyridoxal 5'-phosphate (vitamin B6 active form) and its neuroprotection in experimental ischemic damage.
Topics: 4-Aminobutyrate Transaminase; Aldehyde Oxidoreductases; Animals; Astrocytes; Brain Infarction; Brain | 2007 |
Enhanced activity of GABA receptors inhibits glutamate release induced by focal cerebral ischemia in rat striatum.
Topics: Animals; Brain Ischemia; Corpus Striatum; Cytoprotection; Down-Regulation; Feedback, Physiological; | 2007 |
Gabapentin neuroprotection and seizure suppression in immature mouse brain ischemia.
Topics: Amines; Animals; Animals, Newborn; Anticonvulsants; Atrophy; Behavior, Animal; Body Temperature; Bra | 2008 |
The differential effect of ischemia on the active uptake of dopamine, gamma-aminobutyric acid, and glutamate by brain synaptosomes.
Topics: Animals; Brain; Brain Ischemia; Carotid Arteries; Cerebrovascular Disorders; Dopamine; gamma-Aminobu | 1982 |
Effects of anoxia on the stimulated release of amino acid neurotransmitters in the cerebellum in vitro.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Cerebellum; Female; gamma-Aminobutyric Acid; Gl | 1983 |
[Motor activity and the content of neuroactive amino acids in brain tissues].
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Cats; Cerebral Cortex; Female; gamma-Ami | 1983 |
Neurotransmitter amino acids in the CNS. II. Some changes in amino acid levels in rat brain synaptosomes during and after in vitro anoxia and simulated ischemia.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Culture Techniques; gamma-Aminobutyric A | 1984 |
Neurotransmitter amino acids in the CNS. I. Regional changes in amino acid levels in rat brain during ischemia and reperfusion.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Cerebrovascular Circulation; ga | 1984 |
[Central neurotransmitters in cerebral ischemia and stroke].
Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Cerebral Infarction; Cerebrovascular Diso | 1983 |
Biochemistry of experimental ischemic brain edema.
Topics: Adenine Nucleotides; Animals; Basal Ganglia; Biogenic Amines; Brain; Brain Edema; Brain Ischemia; Cy | 1980 |
Beneficial effect of idebenone (CV-2619) on cerebral ischemia-induced amnesia in rats.
Topics: Amnesia; Animals; Arginine Vasopressin; Avoidance Learning; Benzoquinones; Brain Ischemia; Condition | 1984 |
Brain ischemic lethal aggression: GABA or naloxone worsen, association GABA and naloxone alleviates.
Topics: Animals; Brain Ischemia; Drug Therapy, Combination; gamma-Aminobutyric Acid; Hypoxia, Brain; Male; N | 1984 |
Effect of endogenous central nervous system depressants in ischemic cerebral edema of gerbils.
Topics: 4-Butyrolactone; Animals; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Furans; gamma-Aminobutyr | 1980 |
[Effects of GABA and substance P on metabolism of striatal dopamine following experimental cerebral ischemia].
Topics: Animals; Bicuculline; Brain Ischemia; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Male; Micr | 1993 |
Permanent increase of immunocytochemical reactivity for gamma-aminobutyric acid (GABA), glutamic acid decarboxylase, mitochondrial enzymes, and glial fibrillary acidic protein in rat cerebral cortex damaged by early postnatal hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Brain Ischemia; Cerebral Cortex; Electron Transport Complex IV; gamma-Ami | 1994 |
Insulin elevates hippocampal GABA levels during ischemia. This is independent of its hypoglycemic effect.
Topics: Animals; Brain Ischemia; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Gerbillinae; | 1995 |
Intracerebral human microdialysis. In vivo study of an acute focal ischemic model of the human brain.
Topics: Amino Acids; Brain Ischemia; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Mi | 1995 |
A possible role for phospholipases in the release of neurotransmitter amino acids from ischemic rat cerebral cortex.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Disease Models, Animal; gamma-Aminobutyric Acid | 1995 |
Amino acid and purine release in rat brain following temporary middle cerebral artery occlusion.
Topics: Adenosine; Animals; Brain; Brain Ischemia; Cerebral Arteries; Constriction; Excitatory Amino Acids; | 1994 |
Development of susceptibility to audiogenic seizures following cardiac arrest cerebral ischemia in rats.
Topics: Acoustic Stimulation; Animals; Brain Ischemia; Disease Susceptibility; gamma-Aminobutyric Acid; Glut | 1995 |
Progressive decrease in extracellular GABA concentrations in the post-ischemic period in the striatum: a microdialysis study.
Topics: Animals; Brain Ischemia; Chromatography, High Pressure Liquid; Extracellular Space; gamma-Aminobutyr | 1994 |
Protein synthesis and energy metabolism in hippocampal slices during extended (24 hours) recovery following different periods of ischemia.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Brain Ischemia; Energy Metabolism; gamma-Aminobutyri | 1994 |
Combination therapy protects ischemic brain in rats. A glutamate antagonist plus a gamma-aminobutyric acid agonist.
Topics: Animals; Brain; Brain Ischemia; Cerebral Infarction; Dizocilpine Maleate; Drug Combinations; Excitat | 1994 |
Characterization of glutamate, aspartate, and GABA release from ischemic rat cerebral cortex.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Biological Transport; Brain Ischemia; Cere | 1994 |
Indomethacin modulates ischemia-evoked release of glutamate and adenosine from the rat cerebral cortex.
Topics: Adenosine; Animals; Aspartic Acid; Blood Pressure; Brain Ischemia; Cell Death; Cerebral Cortex; Elec | 1994 |
Ischemia inhibits GABAergic neurons of the rat thalamic reticular nucleus. An immunocytochemical study.
Topics: Animals; Brain Ischemia; gamma-Aminobutyric Acid; Golgi Apparatus; Immunohistochemistry; Male; Neuro | 1994 |
In situ changes in purine nucleotide and N-acetyl concentrations upon inducing global ischemia in cat brain.
Topics: Acetylation; Adenosine; Animals; Aspartic Acid; Brain Ischemia; Cats; Choline; Creatine; Female; gam | 1993 |
BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage.
Topics: Acetylcholine; Amino Acids; Animals; Blood Pressure; Brain Injuries; Brain Ischemia; Cerebral Cortex | 1993 |
Sustained changes in acetylcholine and amino acid contents of brain regions following microsphere embolism in rats.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Cerebral Cortex; Corpus S | 1993 |
Striatal grafts in infarct striatopallidum increase GABA release, reorganize GABAA receptor and improve water-maze learning in the rat.
Topics: Animals; Autoradiography; Brain Ischemia; Brain Tissue Transplantation; Cell Transplantation; Cerebr | 1994 |
Effect of radix salviae miltiorrhizae on EAA and IAA during cerebral ischemia in gerbils: a microdialysis study.
Topics: Amino Acids; Animals; Brain Ischemia; Drugs, Chinese Herbal; Extracellular Space; gamma-Aminobutyric | 1994 |
Striatal grafts in the ischemic striatum improve pallidal GABA release and passive avoidance.
Topics: Animals; Avoidance Learning; Behavior, Animal; Brain Ischemia; Cerebral Infarction; Corpus Striatum; | 1993 |
Parvalbumin immunoreactivity in the hippocampus of the gerbil after transient forebrain ischaemia: a qualitative and quantitative sequential study.
Topics: Animals; Brain Ischemia; Cell Count; Female; gamma-Aminobutyric Acid; Gene Expression Regulation; Ge | 1993 |
GABA agonist "muscimol" is neuroprotective in repetitive transient forebrain ischemia in gerbils.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Corpus Striatum; gamma-Aminobutyric Acid; Gerbillinae; Hip | 1993 |
Effects of repeated cerebral ischemia on extracellular amino acid concentrations measured with intracerebral microdialysis in the gerbil hippocampus.
Topics: Amino Acids; Animals; Brain Ischemia; Disease Models, Animal; Extracellular Space; gamma-Aminobutyri | 1993 |
The influence of experimental ischaemia on protein kinase C and the GABAergic system in the rabbit retina.
Topics: Animals; Brain Ischemia; gamma-Aminobutyric Acid; Immunohistochemistry; Protein Kinase C; Rabbits; R | 1995 |
Effects of hypothermia on the rate of excitatory amino acid release after ischemic depolarization.
Topics: Analysis of Variance; Animals; Aspartic Acid; Body Temperature; Brain Ischemia; Cerebral Cortex; Ele | 1996 |
Effects of hypothermia, pentobarbital, and isoflurane on postdepolarization amino acid release during complete global cerebral ischemia.
Topics: Anesthetics, Inhalation; Animals; Aspartic Acid; Brain Ischemia; Calcium; gamma-Aminobutyric Acid; G | 1996 |
Accumulation of cytotoxins during the development of seizures and edema after hypoxic-ischemic injury in late gestation fetal sheep.
Topics: Animals; Aspartic Acid; Brain Edema; Brain Ischemia; Cytotoxins; Electroencephalography; Extracellul | 1996 |
Gabaergic transmission and tyrosine hydroxylase expression in the nigral dopaminergic neurons: an in vivo study using a reversible ischemia model of rats.
Topics: Animals; Brain Ischemia; Cell Count; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid; Male | 1996 |
The relationship between glutamate release and cerebral blood flow after focal cerebral ischaemia in the cat: effect of pretreatment with enadoline (a kappa receptor agonist).
Topics: Animals; Anti-Arrhythmia Agents; Benzofurans; Blood Glucose; Body Temperature; Brain Ischemia; Cats; | 1996 |
Cerebrospinal fluid concentrations of glutamate and GABA during perinatal cerebral hypoxia-ischemia and seizures.
Topics: Animals; Animals, Newborn; Bicuculline; Brain Ischemia; Convulsants; gamma-Aminobutyric Acid; Glutam | 1996 |
GABA release is enhanced in mouse hippocampal slices in cell-damaging conditions.
Topics: 2,4-Dinitrophenol; Animals; Brain Ischemia; Female; Free Radicals; gamma-Aminobutyric Acid; Hippocam | 1996 |
Modulation of ischemic excitatory neurotransmitter and gamma-aminobutyric acid release during global temporary cerebral ischemia by selective neuronal nitric oxide synthase inhibition.
Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glut | 1997 |
Modulation of ischemic excitatory neurotransmitter and gamma-aminobutyric acid release during global temporary cerebral ischemia by local nitric oxide synthase inhibition.
Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Cerebrovascular Circulation; Chromatography, High Pre | 1997 |
Enhanced GABA release in cell-damaging conditions in the adult and developing mouse hippocampus.
Topics: Animals; Animals, Newborn; Brain Diseases; Brain Ischemia; Calcium; Culture Media; Female; Free Radi | 1997 |
Efflux of gamma-aminobutyric acid caused by changes in ion concentrations and cell swelling simulating the effect of cerebral ischaemia.
Topics: Animals; Brain Edema; Brain Ischemia; Carrier Proteins; Cell Survival; Culture Techniques; Electroly | 1997 |
GABA and glutamate levels in the substantia nigra reticulata following repetitive cerebral ischemia in gerbils.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Chromatography, High Pressure Liquid; Convalescence; | 1997 |
Release of endogenous glutamate, aspartate, GABA, and taurine from hippocampal slices from adult and developing mice under cell-damaging conditions.
Topics: Aging; Animals; Aspartic Acid; Brain Ischemia; Female; gamma-Aminobutyric Acid; Glutamic Acid; Hippo | 1998 |
Focal cerebral ischemia in rats induces expression of P75 neurotrophin receptor in resistant striatal cholinergic neurons.
Topics: Animals; Blood Pressure; Brain Ischemia; Cerebral Arteries; Choline O-Acetyltransferase; Dopamine an | 1998 |
Glutamate, glutamine, and GABA as substrates for the neuronal and glial compartments after focal cerebral ischemia in rats.
Topics: Acetates; Amino Acids; Animals; Arteries; Blood Pressure; Brain; Brain Ischemia; Carbon Isotopes; Cy | 1998 |
Changes in brain organic osmolytes in experimental cerebral ischemia.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Brain Ischemia; Creatine; Disease Mod | 1998 |
Immunohistochemical evidence for dysregulation of the GABAergic system ipsilateral to photochemically induced cortical infarcts in rats.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Dominance, Cerebral; gamma-Aminobutyric Acid; Gene Exp | 1998 |
Modulation of ischemia-evoked release of excitatory and inhibitory amino acids by adenosine A1 receptor agonist.
Topics: Adenosine; Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; gamma-Aminobutyric Acid; Glut | 1998 |
Attenuated neurotransmitter release and spreading depression-like depolarizations after focal ischemia in mutant mice with disrupted type I nitric oxide synthase gene.
Topics: Alanine; Animals; Brain; Brain Ischemia; Cerebral Infarction; Cerebrovascular Circulation; Cortical | 1998 |
[Levels of neurotransmitter amino acids in the cerebrospinal fluid of patients with acute ischemic stroke].
Topics: Acute Disease; Aspartic Acid; Brain Ischemia; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycin | 1999 |
Effects of hyperosmolarity and ion substitutions on amino acid efflux from the ischemic rat cerebral cortex.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Brain Edema; Brain Ischemia; Cerebral Cortex; Chlorides | 1999 |
Hypothermia ameliorates ischemic brain damage and suppresses the release of extracellular amino acids in both normo- and hyperglycemic subjects.
Topics: Animals; Brain; Brain Ischemia; Corpus Striatum; Disease Models, Animal; Excitatory Amino Acids; Ext | 1999 |
Efflux transport of [3H]GABA across blood-brain barrier after cerebral ischemia-reperfusion in rats.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; gamma-Aminobutyric Acid; Male; Microinjections; Proben | 1999 |
Striatal outflow of adenosine, excitatory amino acids, gamma-aminobutyric acid, and taurine in awake freely moving rats after middle cerebral artery occlusion: correlations with neurological deficit and histopathological damage.
Topics: Adenosine; Animals; Arterial Occlusive Diseases; Brain Ischemia; Cerebral Cortex; Chromatography, Hi | 1999 |
Anticonvulsant taurine derivatives modify taurine and GABA release in the mouse hippocampus.
Topics: Aging; Animals; Anticonvulsants; Brain Ischemia; Female; gamma-Aminobutyric Acid; Hippocampus; In Vi | 1999 |
Topical glucose and accumulation of excitotoxic and other amino acids in ischemic cerebral cortex.
Topics: Animals; Aspartic Acid; Blood Pressure; Brain Ischemia; Carbon Dioxide; Cerebral Cortex; Ethanolamin | 2000 |
On the regulation of ischaemia-induced glutamate efflux from rat cortex by GABA; in vitro studies with GABA, clomethiazole and pentobarbitone.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Chlormethiazole; Female; GABA Modulators; gamma-Aminobutyr | 2000 |
The effect of topical insulin on the release of excitotoxic and other amino acids from the rat cerebral cortex during streptozotocin-induced hyperglycemic ischemia.
Topics: Administration, Topical; Animals; Aspartic Acid; Blood Glucose; Brain Ischemia; Cerebral Cortex; Dia | 2000 |
Could flumazenil reverse neurological deficits in acute cerebral ischemia?
Topics: Acute Disease; Brain Ischemia; Carotid Artery Thrombosis; Carotid Artery, Internal; Cerebral Angiogr | 1999 |
Hypothermia inhibits ischemia-induced efflux of amino acids and neuronal damage in the hippocampus of aged rats.
Topics: Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Cerebrovascular Circulation; Ex | 2000 |
Neuroprotective effects of allopregnenolone on hippocampal irreversible neurotoxicity in vitro.
Topics: Animals; Brain Ischemia; Calcium Channels; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In V | 2000 |
Studies on the effects of lactate transport inhibition, pyruvate, glucose and glutamine on amino acid, lactate and glucose release from the ischemic rat cerebral cortex.
Topics: Amino Acids; Animals; Biological Transport; Brain Ischemia; Cerebral Cortex; Coumaric Acids; Disease | 2001 |
Adaptive plasticity in tachykinin and tachykinin receptor expression after focal cerebral ischemia is differentially linked to gabaergic and glutamatergic cerebrocortical circuits and cerebrovenular endothelium.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Cerebrovascular Circulation; Endothelium, Vascular; gamma- | 2001 |
Real-time, two-dimensional visualization of ischaemia-induced glutamate release from hippocampal slices.
Topics: Alanine; Aspartic Acid; Brain Ischemia; Calcium Signaling; Cell Line; Computer Systems; Dentate Gyru | 2001 |
The effect of streptozotocin-induced diabetes on the release of excitotoxic and other amino acids from the ischemic rat cerebral cortex.
Topics: Acute Disease; Amino Acids; Animals; Blood Glucose; Brain Ischemia; Cerebral Cortex; Chronic Disease | 2001 |
1H magnetic resonance spectroscopic imaging of permanent focal cerebral ischemia in rat: longitudinal metabolic changes in ischemic core and rim.
Topics: Animals; Aspartic Acid; Biomarkers; Brain Ischemia; Caudate Nucleus; Circle of Willis; Energy Metabo | 2001 |
Neuroprotective efficacy of AR-A008055, a clomethiazole analogue, in a global model of acute ischaemic stroke and its effect on ischaemia-induced glutamate and GABA efflux in vitro.
Topics: Animals; Brain Ischemia; Chlormethiazole; Female; gamma-Aminobutyric Acid; Gerbillinae; Glutamic Aci | 2001 |
Alterations of amino acid levels from striatum, hippocampus, and cerebral cortex induced by global cerebral ischemia in gerbil.
Topics: Animals; Brain; Brain Ischemia; Cerebral Cortex; Corpus Striatum; Excitatory Amino Acid Antagonists; | 2000 |
Adenosine-mediated inhibition of striatal GABAergic synaptic transmission during in vitro ischaemia.
Topics: Adenosine; Adenosine Triphosphate; Animals; Brain Ischemia; Corpus Striatum; gamma-Aminobutyric Acid | 2001 |
[Effect of guizhi fuling pills on the changes of Ca2+ and amino acids in rats with cerebral ischemia and reperfusion].
Topics: Animals; Brain; Brain Ischemia; Calcium; Drug Combinations; Drugs, Chinese Herbal; Female; gamma-Ami | 1998 |
Profiles of glutamate and GABA efflux in core versus peripheral zones of focal cerebral ischemia in mice.
Topics: Animals; Blood Flow Velocity; Brain; Brain Ischemia; Cerebrovascular Circulation; Disease Models, An | 2001 |
Increases in GABA concentrations during cerebral ischaemia: a microdialysis study of extracellular amino acids.
Topics: Adolescent; Adult; Brain; Brain Ischemia; Catheters, Indwelling; Chromatography, High Pressure Liqui | 2002 |
Influence of inhibition of adenosine uptake on the gamma-aminobutyric acid level of the ischemic rat brain.
Topics: Adenosine; Animals; Biomarkers; Brain; Brain Chemistry; Brain Ischemia; Cerebral Cortex; Dipyridamol | 2002 |
Spatial and temporal alterations in the GABA shunt in the gerbil hippocampus following transient ischemia.
Topics: Aldehyde Oxidoreductases; Animals; Brain Ischemia; Carrier Proteins; GABA Plasma Membrane Transport | 2002 |
[Mechanism of neuronal damage caused by cerebral ischemia].
Topics: Amino Acids; Animals; Brain Ischemia; Corpus Striatum; gamma-Aminobutyric Acid; Glutathione Peroxida | 1992 |
Concomitant increases in the extracellular concentrations of excitatory and inhibitory amino acids in the rat hippocampus during forebrain ischemia.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Cell Death; Consciousness; Ethanolamines | 1992 |
Differing neurochemical and morphological sequelae of global ischemia: comparison of single- and multiple-insult paradigms.
Topics: Analysis of Variance; Animals; Brain Chemistry; Brain Ischemia; Chromatography, High Pressure Liquid | 1992 |
Perinatal hypoxic ischemic encephalopathy affects the proportion of GABA-immunoreactive neurons in the cerebral cortex of the rat.
Topics: Aging; Animals; Animals, Newborn; Brain Ischemia; Cell Count; Cell Survival; Cerebral Cortex; Epilep | 1992 |
Inhibition in postischemic rat hippocampus: GABA receptors, GABA release, and inhibitory postsynaptic potentials.
Topics: Animals; Autoradiography; Brain Ischemia; Dialysis; Electrophysiology; Flumazenil; gamma-Aminobutyri | 1991 |
Enhancement of GABA neurotransmission after cerebral ischemia in the rat reduces loss of hippocampal CA1 pyramidal cells.
Topics: Animals; Arousal; Brain Ischemia; Cell Count; Cell Survival; Diazepam; Dose-Response Relationship, D | 1991 |
The effects of hypothermia on amino acid neurotransmitter release from the cerebral cortex.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutam | 1991 |
Differences in transmitter release, morphology, and ischemia-induced cell injury between cerebellar granule cell cultures developing in the presence and in the absence of a depolarizing potassium concentration.
Topics: Animals; Aspartic Acid; Brain Ischemia; Calcium; Cell Count; Cell Hypoxia; Cells, Cultured; Cerebell | 1991 |
K+ efflux pathways and neurotransmitter release associated to hippocampal ischemia: effects of glucose and of K+ channel blockers.
Topics: 4-Aminopyridine; Animals; Apamin; Aspartic Acid; Barium; Barium Compounds; Brain Ischemia; Calcium C | 1991 |
Elevated gamma-aminobutyric acid levels attenuate the metabolic response to bilateral ischemia.
Topics: Adenosine Triphosphate; Aminocaproates; Animals; Body Temperature; Brain; Brain Ischemia; Energy Met | 1992 |
Effects of bilateral clamping of carotid arteries on hippocampal kindling in rats.
Topics: Animals; Brain Ischemia; Brain Mapping; Female; Frontal Lobe; gamma-Aminobutyric Acid; Hippocampus; | 1991 |
Time-sequential change of amino acid neurotransmitters--GABA, aspartate and glutamate--in the rat basal ganglia following middle cerebral artery occlusion.
Topics: Animals; Aspartic Acid; Basal Ganglia; Brain Ischemia; gamma-Aminobutyric Acid; Glucose; Glutamates; | 1990 |
Effects of hypoxia and hypoglycaemia on DC potentials recorded from the gerbil hippocampus in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cell Hypoxia; gam | 1990 |
WEB 1881 FU ameliorates impairment of working memory induced by scopolamine and cerebral ischemia in the three-panel runway task.
Topics: Animals; Brain Ischemia; gamma-Aminobutyric Acid; Male; Memory; Memory Disorders; Pantothenic Acid; | 1990 |
Cerebral metabolism in man after acute stroke: new observations using localized proton NMR spectroscopy.
Topics: Adult; Aspartic Acid; Brain; Brain Ischemia; Cerebral Infarction; Cerebrovascular Disorders; gamma-A | 1989 |
S-adenosyl-L-methionine ameliorates ischemic brain metabolism in spontaneously hypertensive rats.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Body Water; Brain; Brain Chemistry; Brain Ischemia; | 1989 |
Effects of dynorphin1-13 on opiate binding and dopamine and GABA uptake in stroked cat brain.
Topics: Animals; Brain; Brain Ischemia; Cats; Cyclazocine; Disease Models, Animal; Dopamine; Dynorphins; Eth | 1986 |
[The differential effect of dynorphin on dopamine and GABA uptake in cerebral ischemia].
Topics: Animals; Brain; Brain Ischemia; Cats; Cerebral Cortex; Dopamine; Dynorphins; gamma-Aminobutyric Acid | 1986 |
The effects of etomidate in the cat middle cerebral artery occlusion model of brain ischaemia. An experimental study.
Topics: Animals; Brain; Brain Ischemia; Cats; Cerebral Arteries; Cerebrovascular Circulation; Disease Models | 1986 |
[Regional and time-sequential changes in amino acid neurotransmitters after focal cerebral ischemia in the rat].
Topics: Amino Acids; Animals; Aspartic Acid; Basal Ganglia; Brain; Brain Ischemia; gamma-Aminobutyric Acid; | 1986 |
Extracellular overflow of glutamate, aspartate, GABA and taurine in the cortex and basal ganglia of fetal lambs during hypoxia-ischemia.
Topics: Amino Acids; Animals; Aspartic Acid; Asphyxia; Brain Ischemia; Cerebrovascular Circulation; Evoked P | 1987 |
Role for gamma-aminobutyric acid in selective vulnerability in gerbils.
Topics: Animals; Brain Ischemia; Cell Survival; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Ger | 1989 |
Metabolic alterations in fiber layers of the CA 1 region of the gerbil hippocampus following short-term ischemia: high-energy phosphates, glucose-related metabolites, and amino acids.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Brain Ischemia; Cerebral Cortex; Energy Metabolism; ga | 1988 |
[Effect of MCI-2016 (bifemelane hydrochloride) on cerebral ischemia following ligation of both common carotid arteries in Mongolian gerbils].
Topics: Administration, Oral; Age Factors; Animals; Benzhydryl Compounds; Brain Ischemia; Carotid Artery Dis | 1985 |
Ischemia-induced shift of inhibitory and excitatory amino acids from intra- to extracellular compartments.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Electroencephalography; Extracellular Space; ga | 1985 |
The effects of hyperglycaemia on changes during reperfusion following focal cerebral ischaemia in the cat.
Topics: Animals; Blood Glucose; Brain Ischemia; Cats; Cerebral Cortex; Cerebral Infarction; Cerebrovascular | 1985 |