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gamma-aminobutyric acid and Brain Ischemia

gamma-aminobutyric acid has been researched along with Brain Ischemia in 207 studies

gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.

Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"In this review, we present evidence for the role of gamma-aminobutyric acid (GABA) neurotransmission in cerebral ischemia-induced neuronal death."8.81gamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia. ( Sah, R; Schwartz-Bloom, RD, 2001)
"Compositions of phenibut with salicylic, nicotinic, and glutamic acids in subtotal and transient cerebral ischemia were found to have the most pronounced cerebroprotective effect in doses of 30, 50 and 50 mg/kg, respectively."8.31Experimental Substantiation of the Use of Phenibut Combinations with Salicylic, Nicotinic, and Glutamic Acids in Cerebral Ischemia. ( Monov, D; Pashanova, O, 2023)
"Dexmedetomidine is capable of decreasing glutamergic content, and increasing GABAergic content, in order to decrease the injury of the cerebral ultrastructure, following cerebral ischemia-reperfusion injury."7.85Impact of dexmedetomidine on amino acid contents and the cerebral ultrastructure of rats with cerebral ischemia-reperfusion injury. ( Fu, Z; Lin, S; Shao, W; Zhou, G, 2017)
"To investigate the effects of dexmedetomidine (DEX) on amino acid contents and the cerebral ultrastructure of rats with cerebral ischemia-reperfusion injury (I/R)."7.85Impact of dexmedetomidine on amino acid contents and the cerebral ultrastructure of rats with cerebral ischemia-reperfusion injury. ( Fu, Z; Lin, S; Shao, W; Zhou, G, 2017)
"To observe the effects of L-tetrahydropalmatine (L-THP) on concentrations of neurotransmitter amino acids in mice with cerebral ischemia and to discuss the mechanisms of L-THP in tyreating cerebral ischemia."7.72[Effects of L-tetrahydropalmatine on concentrations of neurotransmitter amino acids in mice with cerebral ischemia]. ( Jiang, B; Zhang, ZM; Zheng, XX; Zhou, Q, 2004)
" This study investigates the utilization of glutamate, glutamine, and GABA as fuel by the neuronal and glial tricarboxylic acid cycles of both cerebral hemispheres after partially reversible focal cerebral ischemia (FCI)."7.70Glutamate, glutamine, and GABA as substrates for the neuronal and glial compartments after focal cerebral ischemia in rats. ( Carceller, F; Cerdán, S; Pascual, JM; Roda, JM, 1998)
"The releases of endogenous glutamate, aspartate, GABA and taurine from hippocampal slices from 7-day-, 3-, 12-, and 18-month-old mice were investigated under cell-damaging conditions using a superfusion system."7.70Release of endogenous glutamate, aspartate, GABA, and taurine from hippocampal slices from adult and developing mice under cell-damaging conditions. ( Oja, SS; Saransaari, P, 1998)
" We, therefore, investigated whether the presumed higher firing frequency and metabolic activity of neurons in such hypoxia-damaged cortical areas would be reflected by an enhanced light microscopic immunoreactivity of gamma-aminobutyric acid (GABA), the two isoforms of glutamic acid decarboxylase (GAD67 and GAD65), the mitochondrial enzymes cytochrome c oxidase and ATP synthase, and/or glial fibrillary acidic, protein (GFAP)."7.69Permanent increase of immunocytochemical reactivity for gamma-aminobutyric acid (GABA), glutamic acid decarboxylase, mitochondrial enzymes, and glial fibrillary acidic protein in rat cerebral cortex damaged by early postnatal hypoxia-ischemia. ( Janszen, AW; Romijn, HJ; Van den Bogert, C, 1994)
"An experimental model of amnesia induced by cerebral ischemia after one-trial passive avoidance learning was established to test the effects of a novel compound, 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone, CV-2619), and some commonly used drugs in rats."7.67Beneficial effect of idebenone (CV-2619) on cerebral ischemia-induced amnesia in rats. ( Nagaoka, A; Nagawa, Y; Take, Y; Yamazaki, N, 1984)
"We present a review of the effects of cerebral ischemia on pre and postsynaptic targets within the GABAergic synapse."6.41gamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia. ( Sah, R; Schwartz-Bloom, RD, 2001)
"We measured 4 plasma amino acid neurotransmitters (glutamic acid, aspartic acid, gamma-aminobutyric acid, and glycine) among 3486 patients with ischemic stroke from 26 hospitals across China."5.69Plasma Amino Acid Neurotransmitters and Ischemic Stroke Prognosis: A Multicenter Prospective Study. ( Chen, J; Guo, D; He, J; Jia, Y; Peng, H; Shi, M; Sun, L; Wang, A; Wang, Y; Xu, Q; Xu, T; Yang, P; Zhang, Y; Zhong, C; Zhu, Z, 2023)
"Increased glutamic acid, aspartic acid, and gamma-aminobutyric acid and decreased glycine in plasma are associated with adverse outcomes after ischemic stroke, suggesting that plasma amino acid neurotransmitters may be potential intervention targets for improving prognosis of ischemic stroke."5.69Plasma Amino Acid Neurotransmitters and Ischemic Stroke Prognosis: A Multicenter Prospective Study. ( Chen, J; Guo, D; He, J; Jia, Y; Peng, H; Shi, M; Sun, L; Wang, A; Wang, Y; Xu, Q; Xu, T; Yang, P; Zhang, Y; Zhong, C; Zhu, Z, 2023)
"Acute seizure activity was behaviorally scored and hemispheric brain atrophy measured."5.35Gabapentin neuroprotection and seizure suppression in immature mouse brain ischemia. ( Comi, AM; Johnston, MV; Kadam, SD; Mulholland, JD; Traa, BS, 2008)
"Seizures were detected by continuous electroencephalographic monitoring for 24 h following permanent middle cerebral artery occlusion (MCAo)."5.33Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats. ( Bautista, CC; Chen, RW; Dave, JR; Hartings, JA; Lu, XC; Tortella, FC; Williams, AJ, 2006)
"Acute seizures following brain injury have been associated with a worsening of patient outcome, but they are often undiagnosed and untreated when they occur without motor convulsions."5.33Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats. ( Bautista, CC; Chen, RW; Dave, JR; Hartings, JA; Lu, XC; Tortella, FC; Williams, AJ, 2006)
"Taurine release was doubled in hypoxia and tripled in ischemia but K+ stimulation was abolished."5.30Release of endogenous glutamate, aspartate, GABA, and taurine from hippocampal slices from adult and developing mice under cell-damaging conditions. ( Oja, SS; Saransaari, P, 1998)
"Nitric oxide release during cerebral ischemia is the result of both neuronal and endothelial subclasses of nitric oxide synthase (NOS)."5.30Modulation of ischemic excitatory neurotransmitter and gamma-aminobutyric acid release during global temporary cerebral ischemia by selective neuronal nitric oxide synthase inhibition. ( Kahn, RA; Panah, M; Weinberger, J, 1997)
"A former study indicated that hypoxic-ischemic encephalopathy in rat sustained during early postnatal life may result in permanent epileptic activity in the baseline electroencephalogram."5.29Permanent increase of immunocytochemical reactivity for gamma-aminobutyric acid (GABA), glutamic acid decarboxylase, mitochondrial enzymes, and glial fibrillary acidic protein in rat cerebral cortex damaged by early postnatal hypoxia-ischemia. ( Janszen, AW; Romijn, HJ; Van den Bogert, C, 1994)
"Muscimol was infused into the third ventricle continuously for 7 days beginning just prior to the insult."5.29GABA agonist "muscimol" is neuroprotective in repetitive transient forebrain ischemia in gerbils. ( Ijaz, S; Mazagri, R; Shuaib, A, 1993)
"The amnesia was estimated by the response latency for a rat to step from a light safety compartment to a dark compartment in which a foot-shock was given."5.27Beneficial effect of idebenone (CV-2619) on cerebral ischemia-induced amnesia in rats. ( Nagaoka, A; Nagawa, Y; Take, Y; Yamazaki, N, 1984)
"In this review, we present evidence for the role of gamma-aminobutyric acid (GABA) neurotransmission in cerebral ischemia-induced neuronal death."4.81gamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia. ( Sah, R; Schwartz-Bloom, RD, 2001)
"Compositions of phenibut with salicylic, nicotinic, and glutamic acids in subtotal and transient cerebral ischemia were found to have the most pronounced cerebroprotective effect in doses of 30, 50 and 50 mg/kg, respectively."4.31Experimental Substantiation of the Use of Phenibut Combinations with Salicylic, Nicotinic, and Glutamic Acids in Cerebral Ischemia. ( Monov, D; Pashanova, O, 2023)
"To investigate the effects of dexmedetomidine (DEX) on amino acid contents and the cerebral ultrastructure of rats with cerebral ischemia-reperfusion injury (I/R)."3.85Impact of dexmedetomidine on amino acid contents and the cerebral ultrastructure of rats with cerebral ischemia-reperfusion injury. ( Fu, Z; Lin, S; Shao, W; Zhou, G, 2017)
"Dexmedetomidine is capable of decreasing glutamergic content, and increasing GABAergic content, in order to decrease the injury of the cerebral ultrastructure, following cerebral ischemia-reperfusion injury."3.85Impact of dexmedetomidine on amino acid contents and the cerebral ultrastructure of rats with cerebral ischemia-reperfusion injury. ( Fu, Z; Lin, S; Shao, W; Zhou, G, 2017)
"Cerebroprotective activity of phenyl derivatives of GABA (phenibut, 25 mg/kg) and L-glutamic acid (neuroglutam, 26 mg/kg) in rats with cerebral ischemia was studied on the background of intact and altered immunoreactivity."3.83NEUROPROTECTIVE ACTION OF PHENIBUT AND NEUROGLUTAM IN EXPERIMENTAL CEREBRAL ISCHEMIA ON THE BACKGROUND OF ALTERED IMMUNOREACTIVITY. ( Bakulin, DA; Filina, IS; Kurkin, DV; Tyurenkov, IN; Volotova, EV, 2016)
" It is established that cerebrovascular activity of the GABA conjugate with prostaglandin E2 under conditions of cerebral ischemia is based on GABAergic mechanisms of vascular tone regulation, since it is removed by GABA(A)-receptor blocker bicuculline."3.79[Cerebrovascular effects of GABA-prostaglandin E2 conjugate in comparison with prostaglandin E2]. ( Bezuglov, VV; Gan'shina, TS; Gorbunova, AV; Gretskaia, NM; Mirzoian, RS, 2013)
" Although a number of studies have investigated that ginkgolide B, a purified terpene lactone component extracted from Ginkgo biloba leaves, is available "platelet activating factor (PAF) receptors antagonist", "antioxidant" with a variety of actions, very little has been performed to explore the effect of ginkgolide B on extracellular amino acids in experimental animal of focal cerebral ischemia/reperfusion."3.77Effect of ginkgolide B on striatal extracellular amino acids in middle cerebral artery occluded rats. ( Feng, W; Li, J; Li, SX; Wang, H; Yang, ZZ, 2011)
"Our latest study indicated that ethanol could attenuate cerebral ischemia/reperfusion-induced brain injury through activating Ionotropic glutamate receptors Kainate Family (Gluk1)-kainate (KA) receptors and gamma-aminobutyric acid (GABA) receptors."3.76Neuroprotection of ethanol against ischemia/reperfusion-induced brain injury through decreasing c-Jun N-terminal kinase 3 (JNK3) activation by enhancing GABA release. ( Gu, YH; Guan, QH; Hao, LY; Liu, Y; Qi, SH; Wang, M; Yan, H; Zhang, GY; Zhang, J, 2010)
"This study investigated the possible involvement of gamma-aminobutyric acid (GABA) in the therapeutic effect of cerebral ischemia by electro-acupuncture (EA) using the rat model with middle cerebral artery occlusion (MCAO)."3.73Role of GABA in electro-acupuncture therapy on cerebral ischemia induced by occlusion of the middle cerebral artery in rats. ( Cheng, JS; Gan, P; Ling, EA; Ng, YK, 2005)
" The neuromodulator adenosine is known to inhibit the presynaptic release of neurotransmitters and to hyperpolarize postsynaptic neurons in the hippocampus, which would imply that it is an endogenous protective agent against cerebral ischemia and excitotoxic neuronal damage."3.73GABA release modified by adenosine receptors in mouse hippocampal slices under normal and ischemic conditions. ( Oja, SS; Saransaari, P, 2005)
"To observe the effects of L-tetrahydropalmatine (L-THP) on concentrations of neurotransmitter amino acids in mice with cerebral ischemia and to discuss the mechanisms of L-THP in tyreating cerebral ischemia."3.72[Effects of L-tetrahydropalmatine on concentrations of neurotransmitter amino acids in mice with cerebral ischemia]. ( Jiang, B; Zhang, ZM; Zheng, XX; Zhou, Q, 2004)
"Experimental studies have suggested that ischemic stroke causes increment in extracellular level of gamma-aminobutyric acid in response to excessive glutamate concentration and function."3.72GABA in ischemic stroke. Proton magnetic resonance study. ( Głodzik-Sobańska, L; Kozub, J; Sobiecka, B; Szczudlik, A; Słowik, A; Urbanik, A, 2004)
"To test the hypothesis of an involvement of tachykinins in destabilization and hyperexcitation of neuronal circuits, gliosis, and neuroinflammation during cerebral ischemia, we investigated cell-specific expressional changes of the genes encoding substance P (SP), neurokinin B (NKB), and the tachykinin/neurokinin receptors (NK1, NK2, and NK3) after middle cerebral artery occlusion (MCAO) in the rat."3.71Adaptive plasticity in tachykinin and tachykinin receptor expression after focal cerebral ischemia is differentially linked to gabaergic and glutamatergic cerebrocortical circuits and cerebrovenular endothelium. ( Culmsee, C; Krieglstein, J; Schafer, MK; Stumm, R; Weihe, E, 2001)
" Therefore, it was aimed to study whether dipyridamole (CAS 58-32-2), an adenosine uptake inhibitor, or adenosine (CAS 58-61-7) could affect the rat brain gamma-aminobutyric acid (GABA, CAS 56-12-2) level after induction of cerebral ischemia, and to test their effect on the lactate dehydrogenase (LDH) activity of the ischemic rat brain."3.71Influence of inhibition of adenosine uptake on the gamma-aminobutyric acid level of the ischemic rat brain. ( Khattab, M; Seif-el-Nasr, M, 2002)
"The releases of endogenous glutamate, aspartate, GABA and taurine from hippocampal slices from 7-day-, 3-, 12-, and 18-month-old mice were investigated under cell-damaging conditions using a superfusion system."3.70Release of endogenous glutamate, aspartate, GABA, and taurine from hippocampal slices from adult and developing mice under cell-damaging conditions. ( Oja, SS; Saransaari, P, 1998)
" This study investigates the utilization of glutamate, glutamine, and GABA as fuel by the neuronal and glial tricarboxylic acid cycles of both cerebral hemispheres after partially reversible focal cerebral ischemia (FCI)."3.70Glutamate, glutamine, and GABA as substrates for the neuronal and glial compartments after focal cerebral ischemia in rats. ( Carceller, F; Cerdán, S; Pascual, JM; Roda, JM, 1998)
" Concentrations of extracellular amino acids (glutamate, aspartate, gamma-aminobutyric acid (GABA) and taurine) and regional blood flow in the striatum of spontaneously hypertensive rats (SHRs) were monitored during cerebral ischemia elicited by bilateral carotid artery occlusion for 40 min and recirculation."3.70Modulation of ischemia-evoked release of excitatory and inhibitory amino acids by adenosine A1 receptor agonist. ( Fujishima, M; Goda, H; Ibayashi, S; Nakane, H; Ooboshi, H; Sadoshima, S, 1998)
"To investigate global cerebral ischemia-induced alterations in the levels of glutamate, aspartate, gamma-aminobutyric acid (GABA), glutamine, glycine, and taurine from hippocampus, striatum, and cerebral cortex in gerbils."3.70Alterations of amino acid levels from striatum, hippocampus, and cerebral cortex induced by global cerebral ischemia in gerbil. ( Hu, G; Rao, MR; Tang, XC; Wang, H, 2000)
"The increases of glutamate, aspartate, glycine, and glutamine induced by acute global cerebral ischemia may constitute the biochemical basis of ischemic brain damage."3.70Alterations of amino acid levels from striatum, hippocampus, and cerebral cortex induced by global cerebral ischemia in gerbil. ( Hu, G; Rao, MR; Tang, XC; Wang, H, 2000)
" We, therefore, investigated whether the presumed higher firing frequency and metabolic activity of neurons in such hypoxia-damaged cortical areas would be reflected by an enhanced light microscopic immunoreactivity of gamma-aminobutyric acid (GABA), the two isoforms of glutamic acid decarboxylase (GAD67 and GAD65), the mitochondrial enzymes cytochrome c oxidase and ATP synthase, and/or glial fibrillary acidic, protein (GFAP)."3.69Permanent increase of immunocytochemical reactivity for gamma-aminobutyric acid (GABA), glutamic acid decarboxylase, mitochondrial enzymes, and glial fibrillary acidic protein in rat cerebral cortex damaged by early postnatal hypoxia-ischemia. ( Janszen, AW; Romijn, HJ; Van den Bogert, C, 1994)
"Cerebrospinal fluid (CSF) concentrations of glutamate and gamma- aminobutyric acid (GABA), as estimates of levels in the extracellular compartment of brain, were determined in 7-day postnatal rats at the terminus of hypoxia-ischemia and during status epilepticus, induced with bicuculline, at 2 and 24 h of recovery."3.69Cerebrospinal fluid concentrations of glutamate and GABA during perinatal cerebral hypoxia-ischemia and seizures. ( Cataltepe, O; Towfighi, J; Vannucci, RC, 1996)
"The involvement of phospholipases in ischemia-evoked release of aspartate, glutamate, glycine, and GABA from the cerebral cortex was studied in a four vessel occlusion rat model of cerebral ischemia/reperfusion."3.69A possible role for phospholipases in the release of neurotransmitter amino acids from ischemic rat cerebral cortex. ( O'Regan, MH; Perkins, LM; Phillis, JW; Smith-Barbour, M, 1995)
"The effects of indomethacin (10 mg/kg) on the release of the transmitter amino acids, glutamate, aspartate, GABA, and of the purines, adenosine and inosine, from the cerebral cortex was studied in a four-vessel occlusion rat model of cerebral ischemia/reperfusion."3.69Indomethacin modulates ischemia-evoked release of glutamate and adenosine from the rat cerebral cortex. ( O'Regan, MH; Perkins, LM; Phillis, JW; Smith-Barbour, M, 1994)
"Using a repeated acquisition procedure in a 3-panel runway apparatus, the effect of WEB 1881 FU on impairment of working memory produced either by scopolamine or by cerebral ischemia was investigated in rats and compared with those of aniracetam and Ca hopantenate."3.68WEB 1881 FU ameliorates impairment of working memory induced by scopolamine and cerebral ischemia in the three-panel runway task. ( Kitajima, I; Ohno, M; Ueki, S; Yamamoto, T, 1990)
"The extracellular concentrations of aspartate, glutamate, glutamine, taurine and gamma-aminobutyric acid in the hippocampus were determined during and after forebrain ischemia (4-vessel model) in the unanaesthetized rat."3.68Concomitant increases in the extracellular concentrations of excitatory and inhibitory amino acids in the rat hippocampus during forebrain ischemia. ( Boulu, RG; Callebert, J; Lekieffre, D; Plotkine, M, 1992)
"An experimental model of amnesia induced by cerebral ischemia after one-trial passive avoidance learning was established to test the effects of a novel compound, 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone, CV-2619), and some commonly used drugs in rats."3.67Beneficial effect of idebenone (CV-2619) on cerebral ischemia-induced amnesia in rats. ( Nagaoka, A; Nagawa, Y; Take, Y; Yamazaki, N, 1984)
" Number and type of adverse events were similar between the three groups."2.94Safety and efficacy of GABA ( Audoli-Inthavong, ML; Bassetti, CL; Chabriat, H; Hermann, DM; Lambert, E; Marx, U; Sors, A; Wattez, M, 2020)
"Cerebral ischemia is a multi-faceted neurodegenerative pathology that causes cellular injury to neurons within the central nervous system."2.44Anesthetic-mediated protection/preconditioning during cerebral ischemia. ( Clarkson, AN, 2007)
"We present a review of the effects of cerebral ischemia on pre and postsynaptic targets within the GABAergic synapse."2.41gamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia. ( Sah, R; Schwartz-Bloom, RD, 2001)
"Cerebral ischemia is the leading cause for long-term disability and mortality in adults due to massive neuronal death."1.91Targeting the interaction of GABA ( Balakrishnan, K; Benke, D; Bhat, MA; Ganley, RP; Hleihil, M; Klohs, J; Vaas, M; Zeilhofer, HU, 2023)
"This study utilized a cerebral ischemia reperfusion (IR) model to produce a stressful brain condition that highlights the possible involvement of a hippocampal GC/pERK1/2/BDNF pathway in the resulting sexual consequences of this ailment."1.72Insights into the role of pERK1/2 signaling in post-cerebral ischemia reperfusion sexual dysfunction in rats. ( El-Sahar, AE; Khattab, MA; Mohammed, RA; Saad, MA; Sayed, RH, 2022)
"Waggle needling, a classical anti-spastic needling technique characterized by combination of acupuncture with joint movement, has gained increasing popularity of spasticity treatment in China."1.56Waggle needling wields preferable neuroprotective and anti-spastic effects on post-stroke spasticity rats by attenuating γ-aminobutyric acid transaminase and enhancing γ-aminobutyric acid. ( Gan, YY; Guo, MW; Li, JL; Ma, LX; Mu, JD; Qian, X; Ren, XX; Song, Y; Sun, TY; Tian, Y; Wang, JX; Yu, WY, 2020)
"Memantine was used as a positive control."1.43Low dose of L-glutamic acid attenuated the neurological dysfunctions and excitotoxicity in bilateral common carotid artery occluded mice. ( Abdul, KK; Justin, A; Ramanathan, M, 2016)
"The mechanical allodynia was significantly increased on day 3 after BCAO compared with that during the pre-BCAO assessment."1.43Effects of Adjuvant Analgesics on Cerebral Ischemia-Induced Mechanical Allodynia. ( Harada, S; Matsuura, W; Tokuyama, S, 2016)
"The development of hind paw mechanical allodynia was measured after BCAO using the von Frey test."1.43Effects of Adjuvant Analgesics on Cerebral Ischemia-Induced Mechanical Allodynia. ( Harada, S; Matsuura, W; Tokuyama, S, 2016)
"Those that developed cerebral ischemia after MCAO were randomized to receive propylene glycol salt water and ligustrazine respectively."1.40Effect of ligustrazine on levels of amino acid neurotransmitters in rat striatum after cerebral ischemia-reperfusion injury. ( Bie, XD; Ge, LJ; Han, J; Wan, HT; Yang, JH; Zhang, YY, 2014)
"Conversely, in painted turtle brain anoxia increases γ-amino butyric acid (GABA)ergic suppression of spontaneous electrical activity, and cell death is prevented."1.38Painted turtle cortex is resistant to an in vitro mimic of the ischemic mammalian penumbra. ( Buck, LT; Gu, XQ; Haddad, GG; Hogg, DW; Pamenter, ME, 2012)
"It is shown that, in rats with global cerebral ischemia modeled by a complete irreversible occlusion of the common carotid artery and forced hypotension, the hemostasis is characterized by a shift toward hypercoagulation."1.38[Effect of phenibut and its composition with nicotinic acid on hemostasis in rats with brain ischemia]. ( Kurkin, DV; Litvinov, AA; Tarasov, AS; Tiurenkov, IN; Volotova, EV, 2012)
"Gabapentin pretreatment (200  mg/kg, intravenously) reduced the infarct volume by 23% after transient focal ischemia in mice."1.37Gabapentin reduces infarct volume but does not suppress peri-infarct depolarizations. ( Ayata, C; Eikermann-Haerter, K; Hoffmann, U; Lee, JH; Qin, T, 2011)
"Cell death in cerebral ischemia is presumably initiated by neural excitotoxicity resulted from the dysfunction of inhibitory neurons in early stage."1.36Ca2+ and acidosis synergistically lead to the dysfunction of cortical GABAergic neurons during ischemia. ( Chen, N; Ge, M; Guan, S; Huang, L; Wang, JH; Zhu, Y, 2010)
"Acute seizure activity was behaviorally scored and hemispheric brain atrophy measured."1.35Gabapentin neuroprotection and seizure suppression in immature mouse brain ischemia. ( Comi, AM; Johnston, MV; Kadam, SD; Mulholland, JD; Traa, BS, 2008)
"After training, cerebral ischemia was induced by MCAO for 120 min, followed by reperfusion."1.35Pre-ischemic treadmill training affects glutamate and gamma aminobutyric acid levels in the striatal dialysate of a rat model of cerebral ischemia. ( Cao, ZJ; Hu, YS; Jia, J; Liu, G; Wu, Y; Xia, CM; Yu, HX; Zheng, QP; Zhu, DN, 2009)
"After global cerebral ischemia, delayed cell death is observed in the thalamic reticular nucleus but the mechanisms involved are not well described."1.35Endonuclease G expression in thalamic reticular nucleus after global cerebral ischemia. ( Diemer, NH; Nielsen, M; Zimmer, J, 2008)
"Ischemia was induced by a 1 h transient middle cerebral artery occlusion (MCAO) in spontaneously hypertensive rats."1.33Decreased expression of vesicular GABA transporter, but not vesicular glutamate, acetylcholine and monoamine transporters in rat brain following focal ischemia. ( Vemuganti, R, 2005)
"Seizures were detected by continuous electroencephalographic monitoring for 24 h following permanent middle cerebral artery occlusion (MCAo)."1.33Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats. ( Bautista, CC; Chen, RW; Dave, JR; Hartings, JA; Lu, XC; Tortella, FC; Williams, AJ, 2006)
"Acute seizures following brain injury have been associated with a worsening of patient outcome, but they are often undiagnosed and untreated when they occur without motor convulsions."1.33Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats. ( Bautista, CC; Chen, RW; Dave, JR; Hartings, JA; Lu, XC; Tortella, FC; Williams, AJ, 2006)
"Ten minutes of cerebral ischemia was produced by tightening the carotid ligatures bilaterally following hypotension."1.33Ischemic preconditioning ameliorates excitotoxicity by shifting glutamate/gamma-aminobutyric acid release and biosynthesis. ( Busto, R; Dave, KR; Lange-Asschenfeldt, C; Pérez-Pinzón, MA; Prado, R; Raval, AP; Saul, I, 2005)
" Compared with the model group, the concentration of Glu in the middle and large dosage groups of TGF, during the 120 min of ischemia, reduced by 38."1.32[Effects of tianma gouteng fang on transmitter amino acids in the hippocampus extracellular liquids in freely moving rats subjected to brain ischemia]. ( Du, GY; Sun, XF; Wang, DQ; Wang, W; Ye, ZG; Zhang, CY; Zhao, DZ, 2004)
"Nonconvulsive seizures (NCSs) after traumatic and ischemic brain injury are often refractory to antiepileptic drug therapy and are associated with a decline in patient outcome."1.32Antiepileptic drug treatment of nonconvulsive seizures induced by experimental focal brain ischemia. ( Hartings, JA; Lu, XM; Moreton, JE; Tortella, FC; Williams, AJ, 2004)
"We introduced intracerebral hemorrhage in each of eight anesthetized New Zealand rabbits by injecting 0."1.32Extracellular glutamate and other amino acids in experimental intracerebral hemorrhage: an in vivo microdialysis study. ( Ali, Z; Baker, G; Guterman, LR; Hopkins, LN; Qureshi, AI; Shuaib, A; Suri, MF; Todd, K, 2003)
"Lactic acidosis has been implicated; however, increases in the excitotoxic amino acid glutamate, which correlate with increased neuronal damage, may be the cause for the increased damage seen in hyperglycemic stroke."1.31The effect of streptozotocin-induced diabetes on the release of excitotoxic and other amino acids from the ischemic rat cerebral cortex. ( Diaz, FG; Guyot, LL; O'Regan, MH; Phillis, JW; Song, D, 2001)
"Efflux of glutamate during cerebral ischemia is known to contribute to brain cell death via processes of excitotoxicity."1.31Profiles of glutamate and GABA efflux in core versus peripheral zones of focal cerebral ischemia in mice. ( Lo, EH; Moskowitz, MA; Newcomb, R; Shimizu-Sasamata, M; Wang, X, 2001)
"Dipyridamole was administered alone and in combination with adenosine and the effect of the drugs on the brain GABA level as well as on LDH activity was determined."1.31Influence of inhibition of adenosine uptake on the gamma-aminobutyric acid level of the ischemic rat brain. ( Khattab, M; Seif-el-Nasr, M, 2002)
"The gerbil global cerebral ischemia model was prepared by bilateral carotid artery occlusion; the contents of amino acids were assayed using high performance liquid chromatography (HPLC) combined with fluorescent detection after precolumn derivatization."1.31Alterations of amino acid levels from striatum, hippocampus, and cerebral cortex induced by global cerebral ischemia in gerbil. ( Hu, G; Rao, MR; Tang, XC; Wang, H, 2000)
"Similarly, the global cerebral ischemia resulted in increase by 80%, 69%, and 83% of aspartate contents in hippocampus, striatum, and cortex, respectively."1.31Alterations of amino acid levels from striatum, hippocampus, and cerebral cortex induced by global cerebral ischemia in gerbil. ( Hu, G; Rao, MR; Tang, XC; Wang, H, 2000)
"To investigate global cerebral ischemia-induced alterations in the levels of glutamate, aspartate, gamma-aminobutyric acid (GABA), glutamine, glycine, and taurine from hippocampus, striatum, and cerebral cortex in gerbils."1.31Alterations of amino acid levels from striatum, hippocampus, and cerebral cortex induced by global cerebral ischemia in gerbil. ( Hu, G; Rao, MR; Tang, XC; Wang, H, 2000)
"Adenosine has been reported to have beneficial effects against ischemic brain damage, although the mechanisms are not fully clarified."1.30Modulation of ischemia-evoked release of excitatory and inhibitory amino acids by adenosine A1 receptor agonist. ( Fujishima, M; Goda, H; Ibayashi, S; Nakane, H; Ooboshi, H; Sadoshima, S, 1998)
"Nitric oxide release during cerebral ischemia is the result of both neuronal and endothelial subclasses of nitric oxide synthase (NOS)."1.30Modulation of ischemic excitatory neurotransmitter and gamma-aminobutyric acid release during global temporary cerebral ischemia by selective neuronal nitric oxide synthase inhibition. ( Kahn, RA; Panah, M; Weinberger, J, 1997)
"Repetitive cerebral ischemia produces more severe damage than a similar single duration insult."1.30GABA and glutamate levels in the substantia nigra reticulata following repetitive cerebral ischemia in gerbils. ( Hussain, S; Ijaz, MS; Kanthan, R; Miyashita, H; Shuaib, A, 1997)
"Taurine release was doubled in hypoxia and tripled in ischemia but K+ stimulation was abolished."1.30Release of endogenous glutamate, aspartate, GABA, and taurine from hippocampal slices from adult and developing mice under cell-damaging conditions. ( Oja, SS; Saransaari, P, 1998)
"As indomethacin is a potent inhibitor of adenosine uptake, these results suggest that, by blocking adenosine uptake, indomethacin could elevate extracellular adenosine levels and depress glutamate and aspartate efflux as a consequence of the activation of adenosine A1 receptors."1.29Indomethacin modulates ischemia-evoked release of glutamate and adenosine from the rat cerebral cortex. ( O'Regan, MH; Perkins, LM; Phillis, JW; Smith-Barbour, M, 1994)
"Muscimol was infused into the third ventricle continuously for 7 days beginning just prior to the insult."1.29GABA agonist "muscimol" is neuroprotective in repetitive transient forebrain ischemia in gerbils. ( Ijaz, S; Mazagri, R; Shuaib, A, 1993)
"A former study indicated that hypoxic-ischemic encephalopathy in rat sustained during early postnatal life may result in permanent epileptic activity in the baseline electroencephalogram."1.29Permanent increase of immunocytochemical reactivity for gamma-aminobutyric acid (GABA), glutamic acid decarboxylase, mitochondrial enzymes, and glial fibrillary acidic protein in rat cerebral cortex damaged by early postnatal hypoxia-ischemia. ( Janszen, AW; Romijn, HJ; Van den Bogert, C, 1994)
"A cardiac arrest was induced with intravenous KCl, and the times until electroencephalograph isoelectricity and terminal depolarization were recorded."1.29Effects of hypothermia on the rate of excitatory amino acid release after ischemic depolarization. ( Nakashima, K; Todd, MM, 1996)
"Susceptibility to audiogenic seizures (AGS) was investigated in Sprague-Dawley rats subjected to cardiac arrest cerebral ischemia (CACI), produced by compression of the major cardiac vessels."1.29Development of susceptibility to audiogenic seizures following cardiac arrest cerebral ischemia in rats. ( Kawahara, N; Kawai, K; Klatzo, I; Penix, LP; Ruetzler, CA, 1995)
"Repetitive cerebral ischemia in gerbils produces delayed neuronal damage in the substantia nigra reticulata (SNr)."1.29Progressive decrease in extracellular GABA concentrations in the post-ischemic period in the striatum: a microdialysis study. ( Ijaz, S; Kanthan, R; Mainprize, T; Miyashita, H; Shuaib, A, 1994)
"Glycine levels were significantly depressed, both pre- and post-ischemia, in cortical superfusates from hypothermic animals in comparison with normothermic rats."1.28The effects of hypothermia on amino acid neurotransmitter release from the cerebral cortex. ( Phillis, JW; Simpson, RE; Walter, GA, 1991)
"The amnesia was estimated by the response latency for a rat to step from a light safety compartment to a dark compartment in which a foot-shock was given."1.27Beneficial effect of idebenone (CV-2619) on cerebral ischemia-induced amnesia in rats. ( Nagaoka, A; Nagawa, Y; Take, Y; Yamazaki, N, 1984)
"The effect of anoxia and ischemia on the release of amino acid transmitters from cerebellar slices induced by veratridine or high [K+] was studied."1.27Effects of anoxia on the stimulated release of amino acid neurotransmitters in the cerebellum in vitro. ( Balázs, R; Bosley, TM; Gordon, RD; Woodhams, PL, 1983)
"Brain ischemia was induced for 10 or 30 min by clamping the common carotid arteries in rabbits whose vertebral arteries had previously been electrocauterized."1.27Ischemia-induced shift of inhibitory and excitatory amino acids from intra- to extracellular compartments. ( Hagberg, H; Hamberger, A; Jacobson, I; Lehmann, A; Nyström, B; Sandberg, M, 1985)

Research

Studies (207)

TimeframeStudies, this research(%)All Research%
pre-199026 (12.56)18.7374
1990's68 (32.85)18.2507
2000's58 (28.02)29.6817
2010's42 (20.29)24.3611
2020's13 (6.28)2.80

Authors

AuthorsStudies
Balakrishnan, K1
Hleihil, M1
Bhat, MA1
Ganley, RP1
Vaas, M1
Klohs, J1
Zeilhofer, HU1
Benke, D1
Lu, Y2
Li, CJ1
Li, WJ1
Zhou, M1
Liu, L2
Liu, BH1
Pu, J1
Li, ZQ1
Zhang, XR1
Li, JW1
Hu, YC1
Wang, YY1
Mei, JJ1
Gao, J1
Ren, BB1
Feng, XD1
Li, RQ1
Mohammed, RA1
Sayed, RH1
El-Sahar, AE1
Khattab, MA1
Saad, MA2
Zakharov, VV1
Borodulina, IV1
Vakhnina, NV1
Monov, D1
Pashanova, O1
Zhu, Z1
Yang, P1
Jia, Y1
Wang, Y3
Shi, M1
Zhong, C1
Peng, H1
Sun, L1
Guo, D1
Xu, Q1
Chen, J1
Wang, A1
Xu, T1
He, J1
Zhang, Y3
Feng, YW1
Huang, YQ1
Yan, Y1
Li, G2
He, XF1
Liang, FY1
Pei, Z1
Lan, Y1
Xu, GQ1
Chabriat, H1
Bassetti, CL1
Marx, U1
Audoli-Inthavong, ML1
Sors, A1
Lambert, E1
Wattez, M1
Hermann, DM1
Wang, JX1
Mu, JD1
Ma, LX1
Sun, TY1
Qian, X1
Yu, WY1
Tian, Y2
Song, Y2
Gan, YY1
Guo, MW1
Ren, XX1
Li, JL1
Li, J3
Chen, L2
Guo, F2
Han, X1
Song, D5
Chen, Y1
Chen, C1
Cheng, O1
Huang, L2
Wang, C1
Ge, R1
Ni, H1
Zhao, S1
Lin, S1
Zhou, G1
Shao, W1
Fu, Z2
Jiang, L1
Li, W1
Mamtilahun, M1
Ma, Y1
Qu, M1
He, X1
Zheng, J1
Zhang, Z2
Yang, GY1
Mayor, D1
Tymianski, M1
Orfila, JE1
Grewal, H1
Dietz, RM1
Strnad, F1
Shimizu, T1
Moreno, M1
Schroeder, C1
Yonchek, J1
Rodgers, KM1
Dingman, A1
Bernard, TJ1
Quillinan, N1
Macklin, WB1
Traystman, RJ1
Herson, PS1
Zhang, M1
Sun, X1
Gong, Y1
Xu, L1
Volotova, EV2
Filina, IS1
Bakulin, DA1
Kurkin, DV2
Tyurenkov, IN1
Zhang, W1
Wang, L1
Pang, X1
Zhang, J2
Guan, Y1
Liu, J1
Wu, YY1
Yu, XL1
Jia, HY1
Mao, QY1
Fang, JQ1
Belozertsev, IuA1
Zapol'skaia, IuA1
Belozertsev, FIu1
Iuntsev, SV1
Russ, JB1
Verina, T1
Comer, JD1
Comi, AM2
Kaltschmidt, JA1
Gorbunova, AV1
Gan'shina, TS2
Gretskaia, NM2
Bezuglov, VV3
Mirzoian, RS2
Han, J1
Wan, HT1
Yang, JH1
Zhang, YY1
Ge, LJ1
Bie, XD1
Berthet, C2
Xin, L1
Buscemi, L1
Benakis, C1
Gruetter, R2
Hirt, L2
Lei, H2
Shao, B1
Zhou, YL1
Wang, H4
Lin, YS1
Abdelsalam, RM1
Kenawy, SA1
Attia, AS1
Kurzepa, J1
Szpetnar, M1
Hordyjewska, A1
Wątroba, S1
Gołąb, P1
Boguszewska-Czubara, A1
Duan, CL1
Liu, CW1
Shen, SW1
Yu, Z1
Mo, JL1
Chen, XH1
Sun, FY1
Safonova, OA1
Popova, TN1
Slivkin, AI1
Talmi, Y1
Mirzoyan, NR1
Hostikyan, NG1
Stepanyan, AG1
Akopyan, AA1
Alikhanyan, KB1
Meliksetyan, VS1
Bagdasaryan, NA1
Gretskaya, NM1
Long, Q1
Hei, Y1
Luo, Q1
Yang, J1
Wei, L1
Liu, W1
Matsuura, W1
Harada, S1
Tokuyama, S1
Ramanathan, M1
Abdul, KK1
Justin, A1
Nielsen, M1
Zimmer, J1
Diemer, NH3
Kumar, M1
Tyagi, N1
Moshal, KS1
Sen, U1
Kundu, S1
Mishra, PK1
Givvimani, S1
Tyagi, SC1
Benveniste, H1
Jia, J1
Hu, YS1
Wu, Y1
Liu, G1
Yu, HX1
Zheng, QP1
Zhu, DN1
Xia, CM1
Cao, ZJ1
Oja, SS10
Saransaari, P10
Ohira, K1
Furuta, T1
Hioki, H1
Nakamura, KC1
Kuramoto, E1
Tanaka, Y1
Funatsu, N1
Shimizu, K1
Oishi, T1
Hayashi, M1
Miyakawa, T1
Kaneko, T1
Nakamura, S1
Fishell, G1
Goldman, JE1
Qi, SH1
Liu, Y1
Hao, LY1
Guan, QH1
Gu, YH1
Yan, H1
Wang, M1
Zhang, GY1
Brady, JD1
Mohr, C1
Rossi, DJ2
Chen, N1
Ge, M1
Zhu, Y1
Guan, S1
Wang, JH1
Luccini, E1
Romei, C1
Di Prisco, S1
Raiteri, M2
Raiteri, L1
Kreuzberg, M1
Kanov, E1
Timofeev, O1
Schwaninger, M1
Monyer, H1
Khodosevich, K1
Chi, OZ1
Hunter, C1
Liu, X1
Chi, Y1
Weiss, HR1
Zhang, S2
Yang, Z1
Sun, Z1
Gomes, JR1
Lobo, AC1
Melo, CV1
Inácio, AR1
Takano, J1
Iwata, N2
Saido, TC1
de Almeida, LP1
Wieloch, T2
Duarte, CB1
Hoffmann, U1
Lee, JH1
Qin, T1
Eikermann-Haerter, K1
Ayata, C1
Yang, ZZ1
Li, SX1
Feng, W1
Xu, X2
Chang, M1
Zhang, C1
Sun, F1
Ricci, L1
Valoti, M1
Sgaragli, G1
Frosini, M1
Alf, MF1
Mlynarik, V1
Vlasov, TD1
Chefu, SG1
Baĭsa, AE1
Leko, MV1
Burov, SV1
Veselkina, OS1
Gnezdilova, AV1
Maslennikov, DV1
Tiurenkov, IN1
Litvinov, AA1
Tarasov, AS1
Pamenter, ME1
Hogg, DW1
Gu, XQ1
Buck, LT1
Haddad, GG1
Allen, NJ3
Attwell, D3
Cozzi, A1
Meli, E1
Carlà, V1
Pellicciari, R1
Moroni, F1
Pellegrini-Giampietro, DE1
Fu, JH1
Du, GY2
Qureshi, AI1
Ali, Z1
Suri, MF1
Shuaib, A8
Baker, G1
Todd, K1
Guterman, LR1
Hopkins, LN1
Costa, C1
Leone, G1
Saulle, E2
Pisani, F1
Bernardi, G2
Calabresi, P2
Zádor, Z1
Benyó, Z1
Lacza, Z1
Hortobágyi, T2
Harkány, T1
Williams, AJ2
Tortella, FC2
Lu, XM1
Moreton, JE1
Hartings, JA2
Frahm, C1
Haupt, C1
Witte, OW2
Zhang, CY1
Wang, W1
Ye, ZG1
Wang, DQ1
Sun, XF1
Zhao, DZ1
Zhang, ZM1
Zheng, XX1
Jiang, B1
Zhou, Q1
Madden, K1
Clark, W1
Lessov, N1
Vemuganti, R1
Gan, P1
Cheng, JS1
Ng, YK1
Ling, EA1
Joh, HD1
Searles, RV1
Selmanoff, M1
Alkayed, NJ1
Koehler, RC1
Hurn, PD1
Murphy, SJ1
Dave, KR1
Lange-Asschenfeldt, C1
Raval, AP1
Prado, R1
Busto, R2
Saul, I1
Pérez-Pinzón, MA1
Kang, TH1
Oh, HR1
Jung, SM1
Ryu, JH1
Park, MW1
Park, YK1
Kim, SY1
Głodzik-Sobańska, L1
Słowik, A1
Kozub, J1
Sobiecka, B1
Urbanik, A1
Szczudlik, A1
Tateishi, N1
Shimoda, T1
Manako, J1
Katsumata, S1
Shinagawa, R1
Ohno, H1
Bautista, CC1
Chen, RW1
Dave, JR1
Lu, XC1
Müller, GJ1
Dogonowski, AM1
Finsen, B1
Johansen, FF4
Clarkson, AN1
Oda, M1
Kure, S1
Sugawara, T1
Yamaguchi, S1
Kojima, K1
Shinka, T1
Sato, K1
Narisawa, A1
Aoki, Y1
Matsubara, Y1
Omae, T1
Mizoi, K1
Kinouchi, H1
Hwang, IK2
Yoo, KY1
Kim, DH1
Lee, BH1
Kwon, YG1
Won, MH2
Ouyang, C1
Guo, L1
Lu, Q1
Traa, BS1
Mulholland, JD1
Kadam, SD1
Johnston, MV1
Weinberger, J3
Cohen, G1
Bosley, TM1
Woodhams, PL1
Gordon, RD1
Balázs, R2
Akopian, VP1
Balian, LS1
Hauptman, M1
Nelson, D2
Wilson, DF2
Erecińska, M2
Silver, IA1
Jellinger, K1
Riederer, P1
Mrsulja, BB1
Djuricić, BM1
Cvejić, V1
Mrsulja, BJ1
Abe, K2
Spatz, M2
Klatzo, I3
Yamazaki, N1
Take, Y1
Nagaoka, A1
Nagawa, Y1
Claperon, N1
Durussel, JJ1
Rossignol, P1
Abe, T1
Li, QY1
Romijn, HJ2
Janszen, AW2
Van den Bogert, C1
Suzdak, PD1
Jansen, JA1
Ijaz, MS2
Waqar, T1
Voll, C1
Kanthan, R5
Miyashita, H5
Griebel, R1
O'Regan, MH9
Smith-Barbour, M4
Perkins, LM4
Phillis, JW10
Kawai, K1
Penix, LP1
Kawahara, N1
Ruetzler, CA1
Ijaz, S2
Mainprize, T1
Djuricic, B1
Berger, R1
Paschen, W1
Lyden, PD1
Lonzo, L1
Gajkowska, B1
Mossakowski, MJ1
van Zijl, PC1
Moonen, CT1
Leach, MJ1
Swan, JH1
Eisenthal, D1
Dopson, M1
Nobbs, M1
Taguchi, T1
Miyake, K1
Tanonaka, K1
Okada, M1
Takagi, N1
Fujimori, K1
Takeo, S1
Aihara, N2
Mizukawa, K1
Koide, K2
Mabe, H1
Nishino, H2
Kuang, P1
Xiang, J1
Kumazaki, M1
Sakurai, T1
Nagai, H1
Tortosa, A1
Ferrer, I1
Mazagri, R1
Nakata, N1
Kato, H1
Kogure, K1
Osborne, NN1
Wood, J1
Muller, A1
Nakashima, K2
Todd, MM2
Tan, WK1
Williams, CE1
During, MJ1
Mallard, CE1
Gunning, MI1
Gunn, AJ1
Gluckman, PD1
Yamada, K1
Goto, S1
Yoshikawa, M1
Ushio, Y1
MacKay, KB1
Patel, TR1
Galbraith, SL1
Woodruff, GN1
McCulloch, J1
Cataltepe, O1
Towfighi, J1
Vannucci, RC1
Kahn, RA2
Panah, M2
Kiffel, S1
Haugstad, TS1
Karlsen, HE1
Krajtci, P1
Due-Tønnessen, B1
Larsen, M1
Sandberg, C1
Sand, O1
Brandtzaeg, P1
Langmoen, IA1
Hussain, S1
Kokaia, Z1
Andsberg, G1
Martinez-Serrano, A1
Lindvall, O1
Pascual, JM1
Carceller, F1
Roda, JM1
Cerdán, S1
Nonaka, M1
Yoshimine, T1
Kohmura, E1
Wakayama, A1
Yamashita, T1
Hayakawa, T1
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Staiger, JF1
Redecker, C1
Zilles, K1
Fritschy, JM1
Möhler, H1
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Shimizu-Sasamata, M2
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Skvortsova, VI1
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Kovalenko, AV1
Kudrin, VS1
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Xiao, XQ1
Melani, A1
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Mishina, M1
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Khattab, M1
Kang, TC1
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Jiang, D1
Lekieffre, D1
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Plotkine, M1
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Lin, B1
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Dietrich, WD1
Martinez, E1
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Buijs, RM1
Swaab, DF1
Christensen, T1
Jensen, MS1
Valente, E1
Jensen, CV1
Nathan, T1
Lambert, JD1
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Walter, GA1
Peng, LA1
Juurlink, BH1
Hertz, L1
Schaeffer, P1
Lazdunski, M1
Abel, MS1
McCandless, DW1
Bortolotto, ZA1
Heim, C1
Sieklucka, M1
Block, F1
Sontag, KH1
Cavalheiro, EA1
Nakayama, H2
Tamura, A1
Kanazawa, I1
Sano, K1
Rogers, H1
Birch, PJ1
Hayes, AG1
Ohno, M1
Yamamoto, T1
Kitajima, I1
Ueki, S1
Bruhn, H1
Frahm, J1
Gyngell, ML1
Merboldt, KD1
Hänicke, W1
Sauter, R1
Kozuka, M1
Palmer, GC1
Kuroda, H2
Baskin, DS1
Matsui, T1
Loh, HH1
Hosobuchi, Y1
Lee, NM1
Takayama, H1
Ota, Z1
Ogawa, N1
Venables, GS2
Strong, AJ2
Miller, SA2
Gibson, G2
Hardy, JA2
Hagberg, H2
Andersson, P1
Kjellmer, I1
Thiringer, K1
Thordstein, M1
Sternau, LL1
Lust, WD2
Ricci, AJ1
Ratcheson, R1
Yasumoto, Y1
Passonneau, JV1
Feussner, G1
Lombroso, CT1
Burchfiel, JL1
Egawa, M1
Hashimoto, N1
Tobe, A1
Lehmann, A1
Sandberg, M1
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Jacobson, I1
Hamberger, A1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized Efficacy and Safety Trial With Oral S 44819 After Recent Ischemic Cerebral Event. International, Multi-centre, Randomized, Doubleblind Placebo-controlled Phase II Study. (RESTORE BRAIN Study)[NCT02877615]Phase 2585 participants (Actual)Interventional2016-12-19Completed
Brain Changes in Pediatric Obstructive Sleep Apnea[NCT05368077]70 participants (Anticipated)Interventional2022-05-14Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

17 reviews available for gamma-aminobutyric acid and Brain Ischemia

ArticleYear
The Effects of GABAergic System under Cerebral Ischemia: Spotlight on Cognitive Function.
    Neural plasticity, 2020, Volume: 2020

    Topics: Animals; Brain Ischemia; Cognition; Cognitive Dysfunction; gamma-Aminobutyric Acid; Hippocampus; Hum

2020
Neurotransmitters in the mediation of cerebral ischemic injury.
    Neuropharmacology, 2018, 05-15, Volume: 134, Issue:Pt B

    Topics: Animals; Brain Ischemia; Calcium; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Receptors, GABA; R

2018
[Neuroprotection in brain ischemia--doubts and hopes].
    Ideggyogyaszati szemle, 2004, Mar-20, Volume: 57, Issue:3-4

    Topics: Animals; Apoptosis; Brain Ischemia; Calcium Channels; Cerebrovascular Circulation; Clinical Trials a

2004
Functional pharmacology in human brain.
    Pharmacological reviews, 2006, Volume: 58, Issue:2

    Topics: Acetylcholine; Alzheimer Disease; Brain; Brain Ischemia; Epilepsy; gamma-Aminobutyric Acid; Glutamic

2006
Anesthetic-mediated protection/preconditioning during cerebral ischemia.
    Life sciences, 2007, Mar-06, Volume: 80, Issue:13

    Topics: Anesthetics, Inhalation; Animals; Brain; Brain Ischemia; Disease Models, Animal; gamma-Aminobutyric

2007
GABA release under normal and ischemic conditions.
    Neurochemical research, 2008, Volume: 33, Issue:5

    Topics: Animals; Brain Ischemia; gamma-Aminobutyric Acid; Humans; Nitric Oxide; Receptors, Glutamate; Second

2008
A review of the preclinical pharmacology of tiagabine: a potent and selective anticonvulsant GABA uptake inhibitor.
    Epilepsia, 1995, Volume: 36, Issue:6

    Topics: Animals; Anticonvulsants; Behavior, Animal; Brain Ischemia; Dogs; gamma-Aminobutyric Acid; Humans; I

1995
Interneurons in rat hippocampus after cerebral ischemia. Morphometric, functional, and therapeutic investigations.
    Acta neurologica Scandinavica. Supplementum, 1993, Volume: 150

    Topics: Animals; Autoradiography; Brain Ischemia; Calcium-Binding Proteins; Cell Death; Cholecystokinin; Dis

1993
Amplification of inhibitory mechanisms in cerebral ischemia: an alternative approach to neuronal protection.
    Histology and histopathology, 1997, Volume: 12, Issue:1

    Topics: Adenosine; Animals; Brain Ischemia; Calcium Channels; gamma-Aminobutyric Acid; Humans; Hypothermia,

1997
Neuronal and endothelial nitric oxide synthase gene knockout mice.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1999, Volume: 32, Issue:11

    Topics: Animals; Brain; Brain Ischemia; Cyclic GMP; Endothelium, Vascular; gamma-Aminobutyric Acid; Glutamic

1999
GABA potentiation: a logical pharmacological approach for the treatment of acute ischaemic stroke.
    Neuropharmacology, 2000, Jul-10, Volume: 39, Issue:9

    Topics: Acute Disease; Animals; Brain; Brain Ischemia; Chlormethiazole; GABA Agonists; gamma-Aminobutyric Ac

2000
An overview of acute stroke therapy: past, present, and future.
    Archives of internal medicine, 2000, Nov-27, Volume: 160, Issue:21

    Topics: Acute Disease; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antibodies; Brain Ischemia;

2000
gamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia.
    Journal of neurochemistry, 2001, Volume: 77, Issue:2

    Topics: Adenosine Triphosphate; Adult; Age Factors; Allosteric Regulation; Animals; Apoptosis; Arachidonic A

2001
[Cerebral metabolic activator (author's transl)].
    No to shinkei = Brain and nerve, 1979, Volume: 31, Issue:8

    Topics: Adenosine Triphosphate; Animals; Barbiturates; Biogenic Amines; Biotransformation; Brain; Brain Isch

1979
Cyclic nucleotides in stroke and related cerebrovascular disorders.
    Life sciences, 1985, May-27, Volume: 36, Issue:21

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenosine; Adenylyl Cyclas

1985
Neurochemical correlates to selective neuronal vulnerability.
    Progress in brain research, 1985, Volume: 63

    Topics: Adenosine; Afferent Pathways; Animals; Aspartic Acid; Brain Diseases; Brain Ischemia; Calcium; Chlor

1985
Etiologic and preventive aspects of epilepsy in the child--bridging the gap between laboratory and clinic.
    Epilepsia, 1987, Volume: 28 Suppl 1

    Topics: Barbiturates; Brain; Brain Ischemia; Child; Child, Preschool; Epilepsy; Female; Fetal Diseases; gamm

1987

Trials

3 trials available for gamma-aminobutyric acid and Brain Ischemia

ArticleYear
[Treatment of patients with chronic cerebral ischemia: experience of using the combined neuroprotective drug Picamilon Ginkgo].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2022, Volume: 122, Issue:9

    Topics: Brain Ischemia; gamma-Aminobutyric Acid; Ginkgo biloba; Humans; Neuroprotective Agents; Phytotherapy

2022
Plasma Amino Acid Neurotransmitters and Ischemic Stroke Prognosis: A Multicenter Prospective Study.
    The American journal of clinical nutrition, 2023, Volume: 118, Issue:4

    Topics: Aspartic Acid; Biomarkers; Brain Ischemia; Cohort Studies; gamma-Aminobutyric Acid; Glutamic Acid; G

2023
Safety and efficacy of GABA
    The Lancet. Neurology, 2020, Volume: 19, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Benzodiazepines; Brain; Brain Ischemia; Double-Blind Method; Female;

2020

Other Studies

187 other studies available for gamma-aminobutyric acid and Brain Ischemia

ArticleYear
Targeting the interaction of GABA
    Brain pathology (Zurich, Switzerland), 2023, Volume: 33, Issue:1

    Topics: Animals; Brain; Brain Ischemia; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cerebral Infarct

2023
Depressive-like behaviors induced by chronic cerebral hypoperfusion associate with a dynamic change of GABA
    Physiology & behavior, 2022, 10-01, Volume: 254

    Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; gamma-Aminobutyric Acid; Hippocampus; Rats; Rats,

2022
The effects of hypothermia on glutamate and γ-aminobutyric acid metabolism during ischemia in monkeys: a repeated-measures ANOVA study.
    Scientific reports, 2022, 08-25, Volume: 12, Issue:1

    Topics: Amino Acids; Analysis of Variance; Animals; Brain Ischemia; gamma-Aminobutyric Acid; Glutamic Acid;

2022
[Effect of electroacupuncture of Governor Vessel on expression of GAD67 and GABA-T in cerebral cortex of rats with post-stroke limb spasticity].
    Zhen ci yan jiu = Acupuncture research, 2022, Aug-25, Volume: 47, Issue:8

    Topics: Animals; Brain Ischemia; Cerebral Cortex; Electroacupuncture; gamma-Aminobutyric Acid; Glutamate Dec

2022
Insights into the role of pERK1/2 signaling in post-cerebral ischemia reperfusion sexual dysfunction in rats.
    European journal of pharmacology, 2022, Oct-15, Volume: 933

    Topics: Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cerebral Infarction; gamma-Aminobutyric

2022
Experimental Substantiation of the Use of Phenibut Combinations with Salicylic, Nicotinic, and Glutamic Acids in Cerebral Ischemia.
    Neurocritical care, 2023, Volume: 39, Issue:2

    Topics: Animals; Brain Ischemia; Cerebral Infarction; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Male;

2023
Phasic GABA signaling mediates the protective effects of cTBS against cerebral ischemia in mice.
    Neuroscience letters, 2020, 01-10, Volume: 715

    Topics: Animals; Brain Ischemia; Electric Stimulation Therapy; GABAergic Neurons; gamma-Aminobutyric Acid; I

2020
Waggle needling wields preferable neuroprotective and anti-spastic effects on post-stroke spasticity rats by attenuating γ-aminobutyric acid transaminase and enhancing γ-aminobutyric acid.
    Neuroreport, 2020, 07-10, Volume: 31, Issue:10

    Topics: 4-Aminobutyrate Transaminase; Acupuncture Therapy; Animals; Brain Ischemia; gamma-Aminobutyric Acid;

2020
GABA
    Stem cell research & therapy, 2021, 01-07, Volume: 12, Issue:1

    Topics: Animals; Brain Ischemia; Cognition; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampu

2021
Ischemia deteriorates spike encoding at cortical GABAergic neurons and cerebellar Purkinje cells by increasing the intracellular Ca
    Brain research bulletin, 2017, Volume: 131

    Topics: Action Potentials; Animals; Brain; Brain Ischemia; Calcium; Cerebral Cortex; Cytoplasm; GABAergic Ne

2017
Impact of dexmedetomidine on amino acid contents and the cerebral ultrastructure of rats with cerebral ischemia-reperfusion injury.
    Acta cirurgica brasileira, 2017, Volume: 32, Issue:6

    Topics: Amino Acids; Animals; Brain Ischemia; Cerebral Cortex; Dexmedetomidine; gamma-Aminobutyric Acid; Glu

2017
Optogenetic Inhibition of Striatal GABAergic Neuronal Activity Improves Outcomes After Ischemic Brain Injury.
    Stroke, 2017, Volume: 48, Issue:12

    Topics: Animals; Brain Ischemia; Corpus Striatum; Endothelial Cells; Fibroblast Growth Factor 2; GABA Antago

2017
Delayed inhibition of tonic inhibition enhances functional recovery following experimental ischemic stroke.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019, Volume: 39, Issue:6

    Topics: Animals; Brain Ischemia; Cognition; gamma-Aminobutyric Acid; Hippocampus; Long-Term Potentiation; Ma

2019
[Ghrelin protects against hippocampal injury after global cerebral ischemia/reperfusion and regulate glutamic acid/γ-aminobutyric acid sensitive neuron discharge]
    Zhonghua wei zhong bing ji jiu yi xue, 2016, Volume: 28, Issue:5

    Topics: Animals; Brain; Brain Ischemia; Cerebral Infarction; gamma-Aminobutyric Acid; Ghrelin; Glutamic Acid

2016
NEUROPROTECTIVE ACTION OF PHENIBUT AND NEUROGLUTAM IN EXPERIMENTAL CEREBRAL ISCHEMIA ON THE BACKGROUND OF ALTERED IMMUNOREACTIVITY.
    Eksperimental'naia i klinicheskaia farmakologiia, 2016, Volume: 79, Issue:4

    Topics: Animals; Animals, Outbred Strains; Biomarkers; Brain Ischemia; Carotid Artery, Common; Cerebrovascul

2016
Role of microRNA-155 in modifying neuroinflammation and γ-aminobutyric acid transporters in specific central regions after post-ischaemic seizures.
    Journal of cellular and molecular medicine, 2019, Volume: 23, Issue:8

    Topics: Amygdala; Animals; Brain Ischemia; Disease Models, Animal; Epilepsy; GABA Plasma Membrane Transport

2019
Temporal effect of acupuncture on amino acid neurotransmitters in rats with acute cerebral ischaemia.
    Acupuncture in medicine : journal of the British Medical Acupuncture Society, 2019, Volume: 37, Issue:4

    Topics: Acupuncture Therapy; Animals; Brain Ischemia; Disease Models, Animal; gamma-Aminobutyric Acid; Gluta

2019
[Comparison of neuroprotective effects of anticonvulsant drugs in brain injury therapy].
    Eksperimental'naia i klinicheskaia farmakologiia, 2012, Volume: 75, Issue:12

    Topics: Amines; Animals; Animals, Outbred Strains; Anticonvulsants; Brain; Brain Injuries; Brain Ischemia; C

2012
Corticospinal tract insult alters GABAergic circuitry in the mammalian spinal cord.
    Frontiers in neural circuits, 2013, Volume: 7

    Topics: Animals; Brain Ischemia; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Interneurons; Mice; Pyram

2013
[Cerebrovascular effects of GABA-prostaglandin E2 conjugate in comparison with prostaglandin E2].
    Eksperimental'naia i klinicheskaia farmakologiia, 2013, Volume: 76, Issue:8

    Topics: Animals; Bicuculline; Brain Ischemia; Cerebrovascular Circulation; Dinoprostone; GABA-A Receptor Ant

2013
Effect of ligustrazine on levels of amino acid neurotransmitters in rat striatum after cerebral ischemia-reperfusion injury.
    Journal of Asian natural products research, 2014, Volume: 16, Issue:11

    Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Corpus Striatum; gamma-Aminobutyric Acid

2014
Non-invasive diagnostic biomarkers for estimating the onset time of permanent cerebral ischemia.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:11

    Topics: Animals; Biomarkers; Brain Ischemia; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamine; Hum

2014
The role of calcitonin gene-related peptide in post-stroke depression in chronic mild stress-treated ischemic rats.
    Physiology & behavior, 2015, Volume: 139

    Topics: Anhedonia; Animals; Antidepressive Agents; Brain Ischemia; Calcitonin Gene-Related Peptide; Chronic

2015
Ischemic preconditioning and postconditioning alleviates hippocampal tissue damage through abrogation of apoptosis modulated by oxidative stress and inflammation during transient global cerebral ischemia-reperfusion in rats.
    Chemico-biological interactions, 2015, May-05, Volume: 232

    Topics: Animals; Apoptosis; Biomarkers; Brain Ischemia; Encephalitis; gamma-Aminobutyric Acid; Glutamic Acid

2015
Thrombolytic treatment decreases glutamate/GABA ratio in serum during acute ischaemic stroke: a pilot study.
    Neurological research, 2015, Volume: 37, Issue:10

    Topics: Aged; Aged, 80 and over; Brain Ischemia; Female; Fibrinolytic Agents; gamma-Aminobutyric Acid; Gluta

2015
Striatal astrocytes transdifferentiate into functional mature neurons following ischemic brain injury.
    Glia, 2015, Volume: 63, Issue:9

    Topics: Animals; Astrocytes; Brain Ischemia; Choline O-Acetyltransferase; Corpus Striatum; Disease Models, A

2015
Effects of a Preparation Containing Pantogam, Succinic Acid, and Chitosan on Activities of the Glutathione System and NADPH-Generating Enzymes in Rat Tissues under Conditions of Cerebral Ischemia/Reperfusion.
    Bulletin of experimental biology and medicine, 2015, Volume: 159, Issue:2

    Topics: Animals; Brain Ischemia; Chitosan; Drug Combinations; Free Radicals; gamma-Aminobutyric Acid; Glucos

2015
[STUDYING NEUROPROTECTIVE ACTIVITY OF GABA CONJUGATE WITH ARACHIDONIC ACID UNDER CONDITIONS OF LOCAL PERMANENT BRAIN ISCHEMIA IN RATS].
    Eksperimental'naia i klinicheskaia farmakologiia, 2015, Volume: 78, Issue:6

    Topics: Animals; Arachidonic Acids; Brain Ischemia; Disease Models, Animal; GABA Agents; gamma-Aminobutyric

2015
BMSCs transplantation improves cognitive impairment via up-regulation of hippocampal GABAergic system in a rat model of chronic cerebral hypoperfusion.
    Neuroscience, 2015, Dec-17, Volume: 311

    Topics: Animals; Bone Marrow Transplantation; Brain Ischemia; Carotid Artery Diseases; Cell Movement; Chroni

2015
Effects of Adjuvant Analgesics on Cerebral Ischemia-Induced Mechanical Allodynia.
    Biological & pharmaceutical bulletin, 2016, Volume: 39, Issue:5

    Topics: Amines; Analgesics; Animals; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Antico

2016
Low dose of L-glutamic acid attenuated the neurological dysfunctions and excitotoxicity in bilateral common carotid artery occluded mice.
    Behavioural pharmacology, 2016, Volume: 27, Issue:7

    Topics: Animals; Brain; Brain Ischemia; Carotid Artery, Common; Disease Models, Animal; Dose-Response Relati

2016
Endonuclease G expression in thalamic reticular nucleus after global cerebral ischemia.
    Experimental brain research, 2008, Volume: 190, Issue:1

    Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Astrocytes; Biomarkers; Brain Infarction; Brain

2008
Homocysteine decreases blood flow to the brain due to vascular resistance in carotid artery.
    Neurochemistry international, 2008, Volume: 53, Issue:6-8

    Topics: Animals; Brain Ischemia; Carotid Arteries; Cerebrovascular Circulation; Collagen; Collagen Type III;

2008
Glutamate, microdialysis, and cerebral ischemia: lost in translation?
    Anesthesiology, 2009, Volume: 110, Issue:2

    Topics: Amino Acids; Animals; Brain Ischemia; gamma-Aminobutyric Acid; Glutamic Acid; Microdialysis; N-Methy

2009
Pre-ischemic treadmill training affects glutamate and gamma aminobutyric acid levels in the striatal dialysate of a rat model of cerebral ischemia.
    Life sciences, 2009, Apr-10, Volume: 84, Issue:15-16

    Topics: Animals; Brain Ischemia; Corpus Striatum; Disease Models, Animal; Exercise Test; gamma-Aminobutyric

2009
Release of endogenous amino acids from the hippocampus and brain stem from developing and adult mice in ischemia.
    Neurochemical research, 2009, Volume: 34, Issue:9

    Topics: Aging; Alanine; Animals; Aspartic Acid; Brain Ischemia; Brain Stem; Female; gamma-Aminobutyric Acid;

2009
Ischemia-induced neurogenesis of neocortical layer 1 progenitor cells.
    Nature neuroscience, 2010, Volume: 13, Issue:2

    Topics: Adult Stem Cells; Animals; Brain Ischemia; Cell Proliferation; gamma-Aminobutyric Acid; Male; Neurog

2010
A silver lining to stroke: does ischemia generate new cortical interneurons?
    Nature neuroscience, 2010, Volume: 13, Issue:2

    Topics: Adult Stem Cells; Animals; Brain Ischemia; Cell Cycle; Cell Movement; Cell Proliferation; Cerebral C

2010
Neuroprotection of ethanol against ischemia/reperfusion-induced brain injury through decreasing c-Jun N-terminal kinase 3 (JNK3) activation by enhancing GABA release.
    Neuroscience, 2010, Jun-02, Volume: 167, Issue:4

    Topics: Animals; Apoptosis; Bicuculline; Brain Ischemia; CA1 Region, Hippocampal; Cadmium Chloride; Calcium

2010
Vesicular GABA release delays the onset of the Purkinje cell terminal depolarization without affecting tissue swelling in cerebellar slices during simulated ischemia.
    Neuroscience, 2010, Jun-16, Volume: 168, Issue:1

    Topics: Animals; Brain Edema; Brain Ischemia; Cerebellum; Excitatory Postsynaptic Potentials; GABA-A Recepto

2010
Ca2+ and acidosis synergistically lead to the dysfunction of cortical GABAergic neurons during ischemia.
    Biochemical and biophysical research communications, 2010, Apr-09, Volume: 394, Issue:3

    Topics: Acidosis; Animals; Apoptosis; Brain Ischemia; Calcium; gamma-Aminobutyric Acid; Mice; Mice, Inbred S

2010
Ionic dysregulations typical of ischemia provoke release of glycine and GABA by multiple mechanisms.
    Journal of neurochemistry, 2010, Volume: 114, Issue:4

    Topics: Animals; Brain Ischemia; Exocytosis; gamma-Aminobutyric Acid; Glycine; Hippocampus; Mice; Mitochondr

2010
Increased subventricular zone-derived cortical neurogenesis after ischemic lesion.
    Experimental neurology, 2010, Volume: 226, Issue:1

    Topics: Animals; Antimetabolites; Apoptosis; Brain Ischemia; Bromodeoxyuridine; Calbindin 2; Caspase 3; Cere

2010
Effects of GABA(A) receptor blockade on regional cerebral blood flow and blood-brain barrier disruption in focal cerebral ischemia.
    Journal of the neurological sciences, 2011, Feb-15, Volume: 301, Issue:1-2

    Topics: Aminoisobutyric Acids; Animals; Antipyrine; Bicuculline; Blood-Brain Barrier; Brain Ischemia; Carbon

2011
Cortical GABAergic neurons and cerebellar Purkinje cells respond to ischemia-pathogenic factors differently.
    Brain research, 2011, Mar-25, Volume: 1382

    Topics: Animals; Brain Ischemia; Cerebellar Cortex; Cerebral Cortex; gamma-Aminobutyric Acid; Interneurons;

2011
Cleavage of the vesicular GABA transporter under excitotoxic conditions is followed by accumulation of the truncated transporter in nonsynaptic sites.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Mar-23, Volume: 31, Issue:12

    Topics: Animals; Blotting, Western; Brain Ischemia; Calpain; DNA; Excitatory Amino Acid Agonists; Female; ga

2011
Gabapentin reduces infarct volume but does not suppress peri-infarct depolarizations.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2011, Volume: 31, Issue:7

    Topics: Amines; Animals; Anticonvulsants; Brain; Brain Infarction; Brain Ischemia; Cortical Spreading Depres

2011
Effect of ginkgolide B on striatal extracellular amino acids in middle cerebral artery occluded rats.
    Journal of ethnopharmacology, 2011, Jun-14, Volume: 136, Issue:1

    Topics: Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Corpus Striatum; gamma-Aminobutyric Acid; Ginkg

2011
Acupuncture to point Baihui prevents ischemia-induced functional impairment of cortical GABAergic neurons.
    Journal of the neurological sciences, 2011, Aug-15, Volume: 307, Issue:1-2

    Topics: Action Potentials; Acupuncture Points; Animals; Brain Ischemia; Cerebral Cortex; Disease Models, Ani

2011
Taurine-like GABA aminotransferase inhibitors prevent rabbit brain slices against oxygen-glucose deprivation-induced damage.
    Amino acids, 2012, Volume: 42, Issue:6

    Topics: 4-Aminobutyrate Transaminase; Animals; Brain; Brain Ischemia; gamma-Aminobutyric Acid; Glucose; Male

2012
High-resolution spatial mapping of changes in the neurochemical profile after focal ischemia in mice.
    NMR in biomedicine, 2012, Volume: 25, Issue:2

    Topics: Animals; Aspartic Acid; Brain Ischemia; gamma-Aminobutyric Acid; Glutamic Acid; Glutathione; Infarct

2012
[Amides of creatine: perspectives of neuroprotection].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2011, Volume: 97, Issue:7

    Topics: Amides; Animals; Brain Ischemia; Creatine; Female; gamma-Aminobutyric Acid; Glycine; Hemodynamics; I

2011
[Cerebrovascular effects of GABA conjugate with arachidonic acid under conditions of separate and combined vascular pathology of brain and heart].
    Eksperimental'naia i klinicheskaia farmakologiia, 2011, Volume: 74, Issue:8

    Topics: Animals; Arachidonic Acid; Blood Pressure; Brain; Brain Ischemia; Carotid Artery, Common; Cerebrovas

2011
[Effect of phenibut and its composition with nicotinic acid on hemostasis in rats with brain ischemia].
    Eksperimental'naia i klinicheskaia farmakologiia, 2012, Volume: 75, Issue:4

    Topics: Animals; Anticonvulsants; Brain Ischemia; gamma-Aminobutyric Acid; Hemostasis; Male; Niacin; Rats; R

2012
Painted turtle cortex is resistant to an in vitro mimic of the ischemic mammalian penumbra.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2012, Volume: 32, Issue:11

    Topics: Action Potentials; Animals; Brain Ischemia; Cell Survival; Cerebral Cortex; Cerebrovascular Circulat

2012
Modulation of ASIC channels in rat cerebellar Purkinje neurons by ischaemia-related signals.
    The Journal of physiology, 2002, Sep-01, Volume: 543, Issue:Pt 2

    Topics: Acid Sensing Ion Channels; Acidosis; Animals; Arachidonic Acid; Brain Ischemia; Cations; gamma-Amino

2002
Metabotropic glutamate 1 (mGlu1) receptor antagonists enhance GABAergic neurotransmission: a mechanism for the attenuation of post-ischemic injury and epileptiform activity?
    Neuropharmacology, 2002, Volume: 43, Issue:2

    Topics: Animals; Brain Ischemia; Cerebral Cortex; Epilepsy; Excitatory Amino Acid Antagonists; gamma-Aminobu

2002
[Effect of tianma cuzhi keli (TMCZKL) on contents of transmitter amino acids of brain tissue in the mouse repetitious cerebral ischemia reperfusion].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2001, Volume: 26, Issue:1

    Topics: Animals; Aspartic Acid; Brain Ischemia; Cerebral Cortex; Drug Combinations; Drugs, Chinese Herbal; g

2001
Extracellular glutamate and other amino acids in experimental intracerebral hemorrhage: an in vivo microdialysis study.
    Critical care medicine, 2003, Volume: 31, Issue:5

    Topics: Analysis of Variance; Animals; Asparagine; Aspartic Acid; Brain Ischemia; Cerebral Hemorrhage; Chrom

2003
Coactivation of GABA(A) and GABA(B) receptor results in neuroprotection during in vitro ischemia.
    Stroke, 2004, Volume: 35, Issue:2

    Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain Ischemia; Carrier Proteins; Cerebral C

2004
Sequential release of GABA by exocytosis and reversed uptake leads to neuronal swelling in simulated ischemia of hippocampal slices.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Apr-14, Volume: 24, Issue:15

    Topics: Action Potentials; Animals; beta-Alanine; Brain Ischemia; Calcium; Carrier Proteins; Cell Size; Exci

2004
Antiepileptic drug treatment of nonconvulsive seizures induced by experimental focal brain ischemia.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 311, Issue:1

    Topics: Amines; Animals; Anticonvulsants; Brain Infarction; Brain Injuries; Brain Ischemia; Cyclohexanecarbo

2004
Metabotropic glutamate receptors modulate ischemia-induced GABA release in mouse hippocampal slices.
    Neurochemical research, 2004, Volume: 29, Issue:8

    Topics: Animals; Animals, Newborn; Brain Ischemia; gamma-Aminobutyric Acid; Glutamates; Hippocampus; In Vitr

2004
GABA neurons survive focal ischemic injury.
    Neuroscience, 2004, Volume: 127, Issue:2

    Topics: Animals; Brain Ischemia; Cell Survival; Cerebral Cortex; Disease Models, Animal; Down-Regulation; Fu

2004
The effect of simulated ischaemia on spontaneous GABA release in area CA1 of the juvenile rat hippocampus.
    The Journal of physiology, 2004, Dec-01, Volume: 561, Issue:Pt 2

    Topics: Age Factors; Animals; Brain Ischemia; Cell Hypoxia; gamma-Aminobutyric Acid; Hippocampus; In Vitro T

2004
[Effects of tianma gouteng fang on transmitter amino acids in the hippocampus extracellular liquids in freely moving rats subjected to brain ischemia].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2004, Volume: 29, Issue:11

    Topics: Animals; Arginine; Brain Ischemia; Drug Combinations; Drugs, Chinese Herbal; Excitatory Amino Acids;

2004
[Effects of L-tetrahydropalmatine on concentrations of neurotransmitter amino acids in mice with cerebral ischemia].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2004, Volume: 29, Issue:4

    Topics: Animals; Berberine Alkaloids; Brain; Brain Ischemia; Drugs, Chinese Herbal; Female; gamma-Aminobutyr

2004
Failure of ischemic neuroprotection by potentiators of gamma-aminobutyric acid.
    Clinical medicine & research, 2003, Volume: 1, Issue:2

    Topics: Animals; Anticonvulsants; Brain Ischemia; Disease Models, Animal; Fructose; gamma-Aminobutyric Acid;

2003
Decreased expression of vesicular GABA transporter, but not vesicular glutamate, acetylcholine and monoamine transporters in rat brain following focal ischemia.
    Neurochemistry international, 2005, Volume: 47, Issue:1-2

    Topics: Animals; Brain; Brain Ischemia; Cerebral Cortex; Disease Models, Animal; Down-Regulation; gamma-Amin

2005
Role of GABA in electro-acupuncture therapy on cerebral ischemia induced by occlusion of the middle cerebral artery in rats.
    Neuroscience letters, 2005, Aug-05, Volume: 383, Issue:3

    Topics: Animals; Brain Ischemia; Cell Survival; Cerebral Cortex; Dose-Response Relationship, Drug; Electroac

2005
GABA release modified by adenosine receptors in mouse hippocampal slices under normal and ischemic conditions.
    Neurochemical research, 2005, Volume: 30, Issue:4

    Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor

2005
Estradiol alters only GAD67 mRNA levels in ischemic rat brain with no consequent effects on GABA.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2006, Volume: 26, Issue:4

    Topics: Animals; Brain Chemistry; Brain Ischemia; Cerebral Cortex; Corpus Striatum; Estradiol; Female; gamma

2006
Ischemic preconditioning ameliorates excitotoxicity by shifting glutamate/gamma-aminobutyric acid release and biosynthesis.
    Journal of neuroscience research, 2005, Dec-01, Volume: 82, Issue:5

    Topics: Animals; Brain Ischemia; Cell Death; Disease Models, Animal; Extracellular Fluid; GABA Agonists; gam

2005
Characteristics of GABA release in mouse brain stem slices under normal and ischemic conditions.
    Neurochemical research, 2005, Volume: 30, Issue:12

    Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfo

2005
Enhancement of neuroprotection of mulberry leaves (Morus alba L.) prepared by the anaerobic treatment against ischemic damage.
    Biological & pharmaceutical bulletin, 2006, Volume: 29, Issue:2

    Topics: Anaerobiosis; Animals; Brain Ischemia; Cell Hypoxia; Cell Survival; Cerebral Infarction; gamma-Amino

2006
GABA in ischemic stroke. Proton magnetic resonance study.
    Medical science monitor : international medical journal of experimental and clinical research, 2004, Volume: 10 Suppl 3

    Topics: Aged; Aged, 80 and over; Brain Ischemia; Case-Control Studies; Female; gamma-Aminobutyric Acid; Huma

2004
Relevance of astrocytic activation to reductions of astrocytic GABAA receptors.
    Brain research, 2006, May-17, Volume: 1089, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Astrocytes; Biomarkers; Brain Ischemia; Cell Communication; Cell M

2006
Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 318, Issue:3

    Topics: Acute Disease; Amines; Animals; Brain Ischemia; Cyclohexanecarboxylic Acids; Dose-Response Relations

2006
Expression of glutamic acid decarboxylase and identification of GABAergic cells in the ischemic rat dentate gyrus.
    Experimental brain research, 2006, Volume: 175, Issue:3

    Topics: Animals; Biomarkers; Brain Ischemia; Cell Count; Dentate Gyrus; Fluoresceins; gamma-Aminobutyric Aci

2006
Modulation of GABA release by second messenger substances and NO in mouse brain stem slices under normal and ischemic conditions.
    Neurochemical research, 2006, Volume: 31, Issue:11

    Topics: Animals; Brain Ischemia; Brain Stem; Cyclic AMP; Enzyme Activators; Enzyme Inhibitors; Female; GABA

2006
Direct correlation between ischemic injury and extracellular glycine concentration in mice with genetically altered activities of the glycine cleavage multienzyme system.
    Stroke, 2007, Volume: 38, Issue:7

    Topics: Alanine; Amino Acid Oxidoreductases; Animals; Brain Ischemia; Carrier Proteins; Cerebrovascular Circ

2007
Time course of changes in pyridoxal 5'-phosphate (vitamin B6 active form) and its neuroprotection in experimental ischemic damage.
    Experimental neurology, 2007, Volume: 206, Issue:1

    Topics: 4-Aminobutyrate Transaminase; Aldehyde Oxidoreductases; Animals; Astrocytes; Brain Infarction; Brain

2007
Enhanced activity of GABA receptors inhibits glutamate release induced by focal cerebral ischemia in rat striatum.
    Neuroscience letters, 2007, Jun-13, Volume: 420, Issue:2

    Topics: Animals; Brain Ischemia; Corpus Striatum; Cytoprotection; Down-Regulation; Feedback, Physiological;

2007
Gabapentin neuroprotection and seizure suppression in immature mouse brain ischemia.
    Pediatric research, 2008, Volume: 64, Issue:1

    Topics: Amines; Animals; Animals, Newborn; Anticonvulsants; Atrophy; Behavior, Animal; Body Temperature; Bra

2008
The differential effect of ischemia on the active uptake of dopamine, gamma-aminobutyric acid, and glutamate by brain synaptosomes.
    Journal of neurochemistry, 1982, Volume: 38, Issue:4

    Topics: Animals; Brain; Brain Ischemia; Carotid Arteries; Cerebrovascular Disorders; Dopamine; gamma-Aminobu

1982
Effects of anoxia on the stimulated release of amino acid neurotransmitters in the cerebellum in vitro.
    Journal of neurochemistry, 1983, Volume: 40, Issue:1

    Topics: Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Cerebellum; Female; gamma-Aminobutyric Acid; Gl

1983
[Motor activity and the content of neuroactive amino acids in brain tissues].
    Biulleten' eksperimental'noi biologii i meditsiny, 1983, Volume: 96, Issue:7

    Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Cats; Cerebral Cortex; Female; gamma-Ami

1983
Neurotransmitter amino acids in the CNS. II. Some changes in amino acid levels in rat brain synaptosomes during and after in vitro anoxia and simulated ischemia.
    Brain research, 1984, Jun-18, Volume: 304, Issue:1

    Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Culture Techniques; gamma-Aminobutyric A

1984
Neurotransmitter amino acids in the CNS. I. Regional changes in amino acid levels in rat brain during ischemia and reperfusion.
    Brain research, 1984, Jun-18, Volume: 304, Issue:1

    Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Cerebrovascular Circulation; ga

1984
[Central neurotransmitters in cerebral ischemia and stroke].
    Fortschritte der Neurologie-Psychiatrie, 1983, Volume: 51, Issue:3

    Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Cerebral Infarction; Cerebrovascular Diso

1983
Biochemistry of experimental ischemic brain edema.
    Advances in neurology, 1980, Volume: 28

    Topics: Adenine Nucleotides; Animals; Basal Ganglia; Biogenic Amines; Brain; Brain Edema; Brain Ischemia; Cy

1980
Beneficial effect of idebenone (CV-2619) on cerebral ischemia-induced amnesia in rats.
    Japanese journal of pharmacology, 1984, Volume: 36, Issue:3

    Topics: Amnesia; Animals; Arginine Vasopressin; Avoidance Learning; Benzoquinones; Brain Ischemia; Condition

1984
Brain ischemic lethal aggression: GABA or naloxone worsen, association GABA and naloxone alleviates.
    Pharmacological research communications, 1984, Volume: 16, Issue:1

    Topics: Animals; Brain Ischemia; Drug Therapy, Combination; gamma-Aminobutyric Acid; Hypoxia, Brain; Male; N

1984
Effect of endogenous central nervous system depressants in ischemic cerebral edema of gerbils.
    Advances in neurology, 1980, Volume: 28

    Topics: 4-Butyrolactone; Animals; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Furans; gamma-Aminobutyr

1980
[Effects of GABA and substance P on metabolism of striatal dopamine following experimental cerebral ischemia].
    Zhonghua yi xue za zhi, 1993, Volume: 73, Issue:11

    Topics: Animals; Bicuculline; Brain Ischemia; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Male; Micr

1993
Permanent increase of immunocytochemical reactivity for gamma-aminobutyric acid (GABA), glutamic acid decarboxylase, mitochondrial enzymes, and glial fibrillary acidic protein in rat cerebral cortex damaged by early postnatal hypoxia-ischemia.
    Acta neuropathologica, 1994, Volume: 87, Issue:6

    Topics: Animals; Animals, Newborn; Brain Ischemia; Cerebral Cortex; Electron Transport Complex IV; gamma-Ami

1994
Insulin elevates hippocampal GABA levels during ischemia. This is independent of its hypoglycemic effect.
    Neuroscience, 1995, Volume: 67, Issue:4

    Topics: Animals; Brain Ischemia; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Gerbillinae;

1995
Intracerebral human microdialysis. In vivo study of an acute focal ischemic model of the human brain.
    Stroke, 1995, Volume: 26, Issue:5

    Topics: Amino Acids; Brain Ischemia; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Mi

1995
A possible role for phospholipases in the release of neurotransmitter amino acids from ischemic rat cerebral cortex.
    Neuroscience letters, 1995, Feb-13, Volume: 185, Issue:3

    Topics: Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Disease Models, Animal; gamma-Aminobutyric Acid

1995
Amino acid and purine release in rat brain following temporary middle cerebral artery occlusion.
    Neurochemical research, 1994, Volume: 19, Issue:9

    Topics: Adenosine; Animals; Brain; Brain Ischemia; Cerebral Arteries; Constriction; Excitatory Amino Acids;

1994
Development of susceptibility to audiogenic seizures following cardiac arrest cerebral ischemia in rats.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1995, Volume: 15, Issue:2

    Topics: Acoustic Stimulation; Animals; Brain Ischemia; Disease Susceptibility; gamma-Aminobutyric Acid; Glut

1995
Progressive decrease in extracellular GABA concentrations in the post-ischemic period in the striatum: a microdialysis study.
    Brain research, 1994, Dec-12, Volume: 666, Issue:1

    Topics: Animals; Brain Ischemia; Chromatography, High Pressure Liquid; Extracellular Space; gamma-Aminobutyr

1994
Protein synthesis and energy metabolism in hippocampal slices during extended (24 hours) recovery following different periods of ischemia.
    Metabolic brain disease, 1994, Volume: 9, Issue:4

    Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Brain Ischemia; Energy Metabolism; gamma-Aminobutyri

1994
Combination therapy protects ischemic brain in rats. A glutamate antagonist plus a gamma-aminobutyric acid agonist.
    Stroke, 1994, Volume: 25, Issue:1

    Topics: Animals; Brain; Brain Ischemia; Cerebral Infarction; Dizocilpine Maleate; Drug Combinations; Excitat

1994
Characterization of glutamate, aspartate, and GABA release from ischemic rat cerebral cortex.
    Brain research bulletin, 1994, Volume: 34, Issue:5

    Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Biological Transport; Brain Ischemia; Cere

1994
Indomethacin modulates ischemia-evoked release of glutamate and adenosine from the rat cerebral cortex.
    Brain research, 1994, Aug-01, Volume: 652, Issue:2

    Topics: Adenosine; Animals; Aspartic Acid; Blood Pressure; Brain Ischemia; Cell Death; Cerebral Cortex; Elec

1994
Ischemia inhibits GABAergic neurons of the rat thalamic reticular nucleus. An immunocytochemical study.
    Folia neuropathologica, 1994, Volume: 32, Issue:3

    Topics: Animals; Brain Ischemia; gamma-Aminobutyric Acid; Golgi Apparatus; Immunohistochemistry; Male; Neuro

1994
In situ changes in purine nucleotide and N-acetyl concentrations upon inducing global ischemia in cat brain.
    Magnetic resonance in medicine, 1993, Volume: 29, Issue:3

    Topics: Acetylation; Adenosine; Animals; Aspartic Acid; Brain Ischemia; Cats; Choline; Creatine; Female; gam

1993
BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage.
    Stroke, 1993, Volume: 24, Issue:7

    Topics: Acetylcholine; Amino Acids; Animals; Blood Pressure; Brain Injuries; Brain Ischemia; Cerebral Cortex

1993
Sustained changes in acetylcholine and amino acid contents of brain regions following microsphere embolism in rats.
    Japanese journal of pharmacology, 1993, Volume: 62, Issue:3

    Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Cerebral Cortex; Corpus S

1993
Striatal grafts in infarct striatopallidum increase GABA release, reorganize GABAA receptor and improve water-maze learning in the rat.
    Brain research bulletin, 1994, Volume: 33, Issue:5

    Topics: Animals; Autoradiography; Brain Ischemia; Brain Tissue Transplantation; Cell Transplantation; Cerebr

1994
Effect of radix salviae miltiorrhizae on EAA and IAA during cerebral ischemia in gerbils: a microdialysis study.
    Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 1994, Volume: 14, Issue:1

    Topics: Amino Acids; Animals; Brain Ischemia; Drugs, Chinese Herbal; Extracellular Space; gamma-Aminobutyric

1994
Striatal grafts in the ischemic striatum improve pallidal GABA release and passive avoidance.
    Brain research bulletin, 1993, Volume: 32, Issue:5

    Topics: Animals; Avoidance Learning; Behavior, Animal; Brain Ischemia; Cerebral Infarction; Corpus Striatum;

1993
Parvalbumin immunoreactivity in the hippocampus of the gerbil after transient forebrain ischaemia: a qualitative and quantitative sequential study.
    Neuroscience, 1993, Volume: 55, Issue:1

    Topics: Animals; Brain Ischemia; Cell Count; Female; gamma-Aminobutyric Acid; Gene Expression Regulation; Ge

1993
GABA agonist "muscimol" is neuroprotective in repetitive transient forebrain ischemia in gerbils.
    Experimental neurology, 1993, Volume: 123, Issue:2

    Topics: Animals; Brain Ischemia; Cerebral Cortex; Corpus Striatum; gamma-Aminobutyric Acid; Gerbillinae; Hip

1993
Effects of repeated cerebral ischemia on extracellular amino acid concentrations measured with intracerebral microdialysis in the gerbil hippocampus.
    Stroke, 1993, Volume: 24, Issue:3

    Topics: Amino Acids; Animals; Brain Ischemia; Disease Models, Animal; Extracellular Space; gamma-Aminobutyri

1993
The influence of experimental ischaemia on protein kinase C and the GABAergic system in the rabbit retina.
    Neuropharmacology, 1995, Volume: 34, Issue:10

    Topics: Animals; Brain Ischemia; gamma-Aminobutyric Acid; Immunohistochemistry; Protein Kinase C; Rabbits; R

1995
Effects of hypothermia on the rate of excitatory amino acid release after ischemic depolarization.
    Stroke, 1996, Volume: 27, Issue:5

    Topics: Analysis of Variance; Animals; Aspartic Acid; Body Temperature; Brain Ischemia; Cerebral Cortex; Ele

1996
Effects of hypothermia, pentobarbital, and isoflurane on postdepolarization amino acid release during complete global cerebral ischemia.
    Anesthesiology, 1996, Volume: 85, Issue:1

    Topics: Anesthetics, Inhalation; Animals; Aspartic Acid; Brain Ischemia; Calcium; gamma-Aminobutyric Acid; G

1996
Accumulation of cytotoxins during the development of seizures and edema after hypoxic-ischemic injury in late gestation fetal sheep.
    Pediatric research, 1996, Volume: 39, Issue:5

    Topics: Animals; Aspartic Acid; Brain Edema; Brain Ischemia; Cytotoxins; Electroencephalography; Extracellul

1996
Gabaergic transmission and tyrosine hydroxylase expression in the nigral dopaminergic neurons: an in vivo study using a reversible ischemia model of rats.
    Neuroscience, 1996, Volume: 73, Issue:3

    Topics: Animals; Brain Ischemia; Cell Count; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid; Male

1996
The relationship between glutamate release and cerebral blood flow after focal cerebral ischaemia in the cat: effect of pretreatment with enadoline (a kappa receptor agonist).
    Brain research, 1996, Mar-18, Volume: 712, Issue:2

    Topics: Animals; Anti-Arrhythmia Agents; Benzofurans; Blood Glucose; Body Temperature; Brain Ischemia; Cats;

1996
Cerebrospinal fluid concentrations of glutamate and GABA during perinatal cerebral hypoxia-ischemia and seizures.
    Brain research, 1996, Feb-19, Volume: 709, Issue:2

    Topics: Animals; Animals, Newborn; Bicuculline; Brain Ischemia; Convulsants; gamma-Aminobutyric Acid; Glutam

1996
GABA release is enhanced in mouse hippocampal slices in cell-damaging conditions.
    Proceedings of the Western Pharmacology Society, 1996, Volume: 39

    Topics: 2,4-Dinitrophenol; Animals; Brain Ischemia; Female; Free Radicals; gamma-Aminobutyric Acid; Hippocam

1996
Modulation of ischemic excitatory neurotransmitter and gamma-aminobutyric acid release during global temporary cerebral ischemia by selective neuronal nitric oxide synthase inhibition.
    Anesthesia and analgesia, 1997, Volume: 84, Issue:5

    Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glut

1997
Modulation of ischemic excitatory neurotransmitter and gamma-aminobutyric acid release during global temporary cerebral ischemia by local nitric oxide synthase inhibition.
    Anesthesia and analgesia, 1997, Volume: 84, Issue:5

    Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Cerebrovascular Circulation; Chromatography, High Pre

1997
Enhanced GABA release in cell-damaging conditions in the adult and developing mouse hippocampus.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1997, Volume: 15, Issue:2

    Topics: Animals; Animals, Newborn; Brain Diseases; Brain Ischemia; Calcium; Culture Media; Female; Free Radi

1997
Efflux of gamma-aminobutyric acid caused by changes in ion concentrations and cell swelling simulating the effect of cerebral ischaemia.
    Acta neurochirurgica, 1997, Volume: 139, Issue:5

    Topics: Animals; Brain Edema; Brain Ischemia; Carrier Proteins; Cell Survival; Culture Techniques; Electroly

1997
GABA and glutamate levels in the substantia nigra reticulata following repetitive cerebral ischemia in gerbils.
    Experimental neurology, 1997, Volume: 147, Issue:2

    Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Chromatography, High Pressure Liquid; Convalescence;

1997
Release of endogenous glutamate, aspartate, GABA, and taurine from hippocampal slices from adult and developing mice under cell-damaging conditions.
    Neurochemical research, 1998, Volume: 23, Issue:4

    Topics: Aging; Animals; Aspartic Acid; Brain Ischemia; Female; gamma-Aminobutyric Acid; Glutamic Acid; Hippo

1998
Focal cerebral ischemia in rats induces expression of P75 neurotrophin receptor in resistant striatal cholinergic neurons.
    Neuroscience, 1998, Volume: 84, Issue:4

    Topics: Animals; Blood Pressure; Brain Ischemia; Cerebral Arteries; Choline O-Acetyltransferase; Dopamine an

1998
Glutamate, glutamine, and GABA as substrates for the neuronal and glial compartments after focal cerebral ischemia in rats.
    Stroke, 1998, Volume: 29, Issue:5

    Topics: Acetates; Amino Acids; Animals; Arteries; Blood Pressure; Brain; Brain Ischemia; Carbon Isotopes; Cy

1998
Changes in brain organic osmolytes in experimental cerebral ischemia.
    Journal of the neurological sciences, 1998, Apr-15, Volume: 157, Issue:1

    Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Brain Ischemia; Creatine; Disease Mod

1998
Immunohistochemical evidence for dysregulation of the GABAergic system ipsilateral to photochemically induced cortical infarcts in rats.
    Neuroscience, 1998, Volume: 87, Issue:4

    Topics: Animals; Brain Ischemia; Cerebral Infarction; Dominance, Cerebral; gamma-Aminobutyric Acid; Gene Exp

1998
Modulation of ischemia-evoked release of excitatory and inhibitory amino acids by adenosine A1 receptor agonist.
    European journal of pharmacology, 1998, Sep-18, Volume: 357, Issue:2-3

    Topics: Adenosine; Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; gamma-Aminobutyric Acid; Glut

1998
Attenuated neurotransmitter release and spreading depression-like depolarizations after focal ischemia in mutant mice with disrupted type I nitric oxide synthase gene.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Nov-15, Volume: 18, Issue:22

    Topics: Alanine; Animals; Brain; Brain Ischemia; Cerebral Infarction; Cerebrovascular Circulation; Cortical

1998
[Levels of neurotransmitter amino acids in the cerebrospinal fluid of patients with acute ischemic stroke].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 1999, Volume: 99, Issue:2

    Topics: Acute Disease; Aspartic Acid; Brain Ischemia; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycin

1999
Effects of hyperosmolarity and ion substitutions on amino acid efflux from the ischemic rat cerebral cortex.
    Brain research, 1999, May-15, Volume: 828, Issue:1-2

    Topics: Animals; Blood Gas Analysis; Blood Pressure; Brain Edema; Brain Ischemia; Cerebral Cortex; Chlorides

1999
Hypothermia ameliorates ischemic brain damage and suppresses the release of extracellular amino acids in both normo- and hyperglycemic subjects.
    Experimental neurology, 1999, Volume: 158, Issue:1

    Topics: Animals; Brain; Brain Ischemia; Corpus Striatum; Disease Models, Animal; Excitatory Amino Acids; Ext

1999
Efflux transport of [3H]GABA across blood-brain barrier after cerebral ischemia-reperfusion in rats.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1999, Volume: 20, Issue:3

    Topics: Animals; Blood-Brain Barrier; Brain Ischemia; gamma-Aminobutyric Acid; Male; Microinjections; Proben

1999
Striatal outflow of adenosine, excitatory amino acids, gamma-aminobutyric acid, and taurine in awake freely moving rats after middle cerebral artery occlusion: correlations with neurological deficit and histopathological damage.
    Stroke, 1999, Volume: 30, Issue:11

    Topics: Adenosine; Animals; Arterial Occlusive Diseases; Brain Ischemia; Cerebral Cortex; Chromatography, Hi

1999
Anticonvulsant taurine derivatives modify taurine and GABA release in the mouse hippocampus.
    Proceedings of the Western Pharmacology Society, 1999, Volume: 42

    Topics: Aging; Animals; Anticonvulsants; Brain Ischemia; Female; gamma-Aminobutyric Acid; Hippocampus; In Vi

1999
Topical glucose and accumulation of excitotoxic and other amino acids in ischemic cerebral cortex.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2000, Volume: 32, Issue:1

    Topics: Animals; Aspartic Acid; Blood Pressure; Brain Ischemia; Carbon Dioxide; Cerebral Cortex; Ethanolamin

2000
On the regulation of ischaemia-induced glutamate efflux from rat cortex by GABA; in vitro studies with GABA, clomethiazole and pentobarbitone.
    British journal of pharmacology, 2000, Volume: 130, Issue:5

    Topics: Animals; Brain Ischemia; Cerebral Cortex; Chlormethiazole; Female; GABA Modulators; gamma-Aminobutyr

2000
The effect of topical insulin on the release of excitotoxic and other amino acids from the rat cerebral cortex during streptozotocin-induced hyperglycemic ischemia.
    Brain research, 2000, Jul-28, Volume: 872, Issue:1-2

    Topics: Administration, Topical; Animals; Aspartic Acid; Blood Glucose; Brain Ischemia; Cerebral Cortex; Dia

2000
Could flumazenil reverse neurological deficits in acute cerebral ischemia?
    Italian journal of neurological sciences, 1999, Volume: 20, Issue:1

    Topics: Acute Disease; Brain Ischemia; Carotid Artery Thrombosis; Carotid Artery, Internal; Cerebral Angiogr

1999
Hypothermia inhibits ischemia-induced efflux of amino acids and neuronal damage in the hippocampus of aged rats.
    Brain research, 2000, Nov-24, Volume: 884, Issue:1--2

    Topics: Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Cerebrovascular Circulation; Ex

2000
Neuroprotective effects of allopregnenolone on hippocampal irreversible neurotoxicity in vitro.
    Progress in neuro-psychopharmacology & biological psychiatry, 2000, Volume: 24, Issue:7

    Topics: Animals; Brain Ischemia; Calcium Channels; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In V

2000
Studies on the effects of lactate transport inhibition, pyruvate, glucose and glutamine on amino acid, lactate and glucose release from the ischemic rat cerebral cortex.
    Journal of neurochemistry, 2001, Volume: 76, Issue:1

    Topics: Amino Acids; Animals; Biological Transport; Brain Ischemia; Cerebral Cortex; Coumaric Acids; Disease

2001
Adaptive plasticity in tachykinin and tachykinin receptor expression after focal cerebral ischemia is differentially linked to gabaergic and glutamatergic cerebrocortical circuits and cerebrovenular endothelium.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Feb-01, Volume: 21, Issue:3

    Topics: Animals; Brain Ischemia; Cerebral Cortex; Cerebrovascular Circulation; Endothelium, Vascular; gamma-

2001
Real-time, two-dimensional visualization of ischaemia-induced glutamate release from hippocampal slices.
    The European journal of neuroscience, 2001, Volume: 13, Issue:4

    Topics: Alanine; Aspartic Acid; Brain Ischemia; Calcium Signaling; Cell Line; Computer Systems; Dentate Gyru

2001
The effect of streptozotocin-induced diabetes on the release of excitotoxic and other amino acids from the ischemic rat cerebral cortex.
    Neurosurgery, 2001, Volume: 48, Issue:2

    Topics: Acute Disease; Amino Acids; Animals; Blood Glucose; Brain Ischemia; Cerebral Cortex; Chronic Disease

2001
1H magnetic resonance spectroscopic imaging of permanent focal cerebral ischemia in rat: longitudinal metabolic changes in ischemic core and rim.
    Brain research, 2001, Jul-13, Volume: 907, Issue:1-2

    Topics: Animals; Aspartic Acid; Biomarkers; Brain Ischemia; Caudate Nucleus; Circle of Willis; Energy Metabo

2001
Neuroprotective efficacy of AR-A008055, a clomethiazole analogue, in a global model of acute ischaemic stroke and its effect on ischaemia-induced glutamate and GABA efflux in vitro.
    Neuropharmacology, 2001, Volume: 41, Issue:2

    Topics: Animals; Brain Ischemia; Chlormethiazole; Female; gamma-Aminobutyric Acid; Gerbillinae; Glutamic Aci

2001
Alterations of amino acid levels from striatum, hippocampus, and cerebral cortex induced by global cerebral ischemia in gerbil.
    Acta pharmacologica Sinica, 2000, Volume: 21, Issue:9

    Topics: Animals; Brain; Brain Ischemia; Cerebral Cortex; Corpus Striatum; Excitatory Amino Acid Antagonists;

2000
Adenosine-mediated inhibition of striatal GABAergic synaptic transmission during in vitro ischaemia.
    Brain : a journal of neurology, 2001, Volume: 124, Issue:Pt 9

    Topics: Adenosine; Adenosine Triphosphate; Animals; Brain Ischemia; Corpus Striatum; gamma-Aminobutyric Acid

2001
[Effect of guizhi fuling pills on the changes of Ca2+ and amino acids in rats with cerebral ischemia and reperfusion].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 1998, Volume: 23, Issue:9

    Topics: Animals; Brain; Brain Ischemia; Calcium; Drug Combinations; Drugs, Chinese Herbal; Female; gamma-Ami

1998
Profiles of glutamate and GABA efflux in core versus peripheral zones of focal cerebral ischemia in mice.
    Neuroscience letters, 2001, Nov-09, Volume: 313, Issue:3

    Topics: Animals; Blood Flow Velocity; Brain; Brain Ischemia; Cerebrovascular Circulation; Disease Models, An

2001
Increases in GABA concentrations during cerebral ischaemia: a microdialysis study of extracellular amino acids.
    Journal of neurology, neurosurgery, and psychiatry, 2002, Volume: 72, Issue:1

    Topics: Adolescent; Adult; Brain; Brain Ischemia; Catheters, Indwelling; Chromatography, High Pressure Liqui

2002
Influence of inhibition of adenosine uptake on the gamma-aminobutyric acid level of the ischemic rat brain.
    Arzneimittel-Forschung, 2002, Volume: 52, Issue:5

    Topics: Adenosine; Animals; Biomarkers; Brain; Brain Chemistry; Brain Ischemia; Cerebral Cortex; Dipyridamol

2002
Spatial and temporal alterations in the GABA shunt in the gerbil hippocampus following transient ischemia.
    Brain research, 2002, Jul-19, Volume: 944, Issue:1-2

    Topics: Aldehyde Oxidoreductases; Animals; Brain Ischemia; Carrier Proteins; GABA Plasma Membrane Transport

2002
[Mechanism of neuronal damage caused by cerebral ischemia].
    Zhonghua yi xue za zhi, 1992, Volume: 72, Issue:8

    Topics: Amino Acids; Animals; Brain Ischemia; Corpus Striatum; gamma-Aminobutyric Acid; Glutathione Peroxida

1992
Concomitant increases in the extracellular concentrations of excitatory and inhibitory amino acids in the rat hippocampus during forebrain ischemia.
    Neuroscience letters, 1992, Mar-16, Volume: 137, Issue:1

    Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Cell Death; Consciousness; Ethanolamines

1992
Differing neurochemical and morphological sequelae of global ischemia: comparison of single- and multiple-insult paradigms.
    Journal of neurochemistry, 1992, Volume: 59, Issue:6

    Topics: Analysis of Variance; Animals; Brain Chemistry; Brain Ischemia; Chromatography, High Pressure Liquid

1992
Perinatal hypoxic ischemic encephalopathy affects the proportion of GABA-immunoreactive neurons in the cerebral cortex of the rat.
    Brain research, 1992, Oct-02, Volume: 592, Issue:1-2

    Topics: Aging; Animals; Animals, Newborn; Brain Ischemia; Cell Count; Cell Survival; Cerebral Cortex; Epilep

1992
Inhibition in postischemic rat hippocampus: GABA receptors, GABA release, and inhibitory postsynaptic potentials.
    Experimental brain research, 1991, Volume: 84, Issue:3

    Topics: Animals; Autoradiography; Brain Ischemia; Dialysis; Electrophysiology; Flumazenil; gamma-Aminobutyri

1991
Enhancement of GABA neurotransmission after cerebral ischemia in the rat reduces loss of hippocampal CA1 pyramidal cells.
    Acta neurologica Scandinavica, 1991, Volume: 84, Issue:1

    Topics: Animals; Arousal; Brain Ischemia; Cell Count; Cell Survival; Diazepam; Dose-Response Relationship, D

1991
The effects of hypothermia on amino acid neurotransmitter release from the cerebral cortex.
    Neuroscience letters, 1991, Mar-11, Volume: 124, Issue:1

    Topics: Animals; Aspartic Acid; Brain Ischemia; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutam

1991
Differences in transmitter release, morphology, and ischemia-induced cell injury between cerebellar granule cell cultures developing in the presence and in the absence of a depolarizing potassium concentration.
    Brain research. Developmental brain research, 1991, Nov-19, Volume: 63, Issue:1-2

    Topics: Animals; Aspartic Acid; Brain Ischemia; Calcium; Cell Count; Cell Hypoxia; Cells, Cultured; Cerebell

1991
K+ efflux pathways and neurotransmitter release associated to hippocampal ischemia: effects of glucose and of K+ channel blockers.
    Brain research, 1991, Jan-18, Volume: 539, Issue:1

    Topics: 4-Aminopyridine; Animals; Apamin; Aspartic Acid; Barium; Barium Compounds; Brain Ischemia; Calcium C

1991
Elevated gamma-aminobutyric acid levels attenuate the metabolic response to bilateral ischemia.
    Journal of neurochemistry, 1992, Volume: 58, Issue:2

    Topics: Adenosine Triphosphate; Aminocaproates; Animals; Body Temperature; Brain; Brain Ischemia; Energy Met

1992
Effects of bilateral clamping of carotid arteries on hippocampal kindling in rats.
    Physiology & behavior, 1991, Volume: 49, Issue:4

    Topics: Animals; Brain Ischemia; Brain Mapping; Female; Frontal Lobe; gamma-Aminobutyric Acid; Hippocampus;

1991
Time-sequential change of amino acid neurotransmitters--GABA, aspartate and glutamate--in the rat basal ganglia following middle cerebral artery occlusion.
    Neurological research, 1990, Volume: 12, Issue:4

    Topics: Animals; Aspartic Acid; Basal Ganglia; Brain Ischemia; gamma-Aminobutyric Acid; Glucose; Glutamates;

1990
Effects of hypoxia and hypoglycaemia on DC potentials recorded from the gerbil hippocampus in vitro.
    Naunyn-Schmiedeberg's archives of pharmacology, 1990, Volume: 342, Issue:5

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cell Hypoxia; gam

1990
WEB 1881 FU ameliorates impairment of working memory induced by scopolamine and cerebral ischemia in the three-panel runway task.
    Japanese journal of pharmacology, 1990, Volume: 54, Issue:1

    Topics: Animals; Brain Ischemia; gamma-Aminobutyric Acid; Male; Memory; Memory Disorders; Pantothenic Acid;

1990
Cerebral metabolism in man after acute stroke: new observations using localized proton NMR spectroscopy.
    Magnetic resonance in medicine, 1989, Volume: 9, Issue:1

    Topics: Adult; Aspartic Acid; Brain; Brain Ischemia; Cerebral Infarction; Cerebrovascular Disorders; gamma-A

1989
S-adenosyl-L-methionine ameliorates ischemic brain metabolism in spontaneously hypertensive rats.
    Japanese journal of pharmacology, 1989, Volume: 49, Issue:2

    Topics: Adenosine Triphosphate; Animals; Blood Glucose; Body Water; Brain; Brain Chemistry; Brain Ischemia;

1989
Effects of dynorphin1-13 on opiate binding and dopamine and GABA uptake in stroked cat brain.
    Brain research, 1986, Jul-30, Volume: 379, Issue:1

    Topics: Animals; Brain; Brain Ischemia; Cats; Cyclazocine; Disease Models, Animal; Dopamine; Dynorphins; Eth

1986
[The differential effect of dynorphin on dopamine and GABA uptake in cerebral ischemia].
    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 1986, Volume: 23, Issue:4

    Topics: Animals; Brain; Brain Ischemia; Cats; Cerebral Cortex; Dopamine; Dynorphins; gamma-Aminobutyric Acid

1986
The effects of etomidate in the cat middle cerebral artery occlusion model of brain ischaemia. An experimental study.
    Neurological research, 1986, Volume: 8, Issue:4

    Topics: Animals; Brain; Brain Ischemia; Cats; Cerebral Arteries; Cerebrovascular Circulation; Disease Models

1986
[Regional and time-sequential changes in amino acid neurotransmitters after focal cerebral ischemia in the rat].
    No to shinkei = Brain and nerve, 1986, Volume: 38, Issue:11

    Topics: Amino Acids; Animals; Aspartic Acid; Basal Ganglia; Brain; Brain Ischemia; gamma-Aminobutyric Acid;

1986
Extracellular overflow of glutamate, aspartate, GABA and taurine in the cortex and basal ganglia of fetal lambs during hypoxia-ischemia.
    Neuroscience letters, 1987, Aug-05, Volume: 78, Issue:3

    Topics: Amino Acids; Animals; Aspartic Acid; Asphyxia; Brain Ischemia; Cerebrovascular Circulation; Evoked P

1987
Role for gamma-aminobutyric acid in selective vulnerability in gerbils.
    Stroke, 1989, Volume: 20, Issue:2

    Topics: Animals; Brain Ischemia; Cell Survival; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Ger

1989
Metabolic alterations in fiber layers of the CA 1 region of the gerbil hippocampus following short-term ischemia: high-energy phosphates, glucose-related metabolites, and amino acids.
    Metabolic brain disease, 1988, Volume: 3, Issue:2

    Topics: Adenosine Triphosphate; Amino Acids; Animals; Brain Ischemia; Cerebral Cortex; Energy Metabolism; ga

1988
[Effect of MCI-2016 (bifemelane hydrochloride) on cerebral ischemia following ligation of both common carotid arteries in Mongolian gerbils].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1985, Volume: 85, Issue:6

    Topics: Administration, Oral; Age Factors; Animals; Benzhydryl Compounds; Brain Ischemia; Carotid Artery Dis

1985
Ischemia-induced shift of inhibitory and excitatory amino acids from intra- to extracellular compartments.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1985, Volume: 5, Issue:3

    Topics: Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Electroencephalography; Extracellular Space; ga

1985
The effects of hyperglycaemia on changes during reperfusion following focal cerebral ischaemia in the cat.
    Journal of neurology, neurosurgery, and psychiatry, 1985, Volume: 48, Issue:7

    Topics: Animals; Blood Glucose; Brain Ischemia; Cats; Cerebral Cortex; Cerebral Infarction; Cerebrovascular

1985