gamma-aminobutyric acid has been researched along with Bradyarrhythmia in 17 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Gamma-Aminobutyric acid at 50 nmol/100 nl produced bradycardia and a fall in arterial pressure when injected into both the nucleus ambiguus and C1 area." | 3.67 | Role of the nucleus ambiguus in the regulation of heart rate and arterial pressure. ( Brody, MJ; Machado, BH, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (29.41) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 4 (23.53) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Strain, MM | 1 |
| Espinoza, L | 1 |
| Fedorchak, S | 1 |
| Littlejohn, EL | 1 |
| Andrade, MA | 1 |
| Toney, GM | 1 |
| Boychuk, CR | 1 |
| Sullivan, RW | 1 |
| Ryzewski, M | 1 |
| Holland, MG | 1 |
| Marraffa, JM | 1 |
| Tjen-A-Looi, SC | 3 |
| Guo, ZL | 2 |
| Longhurst, JC | 3 |
| Li, P | 2 |
| Li, M | 2 |
| BHARGAVA, KP | 1 |
| BHATTACHARYA, SS | 1 |
| SRIMAL, RC | 1 |
| Williford, DJ | 1 |
| Hamilton, BL | 1 |
| Souza, JD | 1 |
| Williams, TP | 1 |
| DiMicco, JA | 1 |
| Gillis, RA | 1 |
| McLemore, GL | 1 |
| Billingsley, ML | 1 |
| Severs, WB | 1 |
| Takemoto, Y | 1 |
| Honjo, K | 1 |
| Goshima, Y | 1 |
| Miyamae, T | 1 |
| Misu, Y | 1 |
| Len, WB | 2 |
| Chan, JY | 2 |
| Kishi, T | 1 |
| Hirooka, Y | 1 |
| Sakai, K | 1 |
| Shigematsu, H | 1 |
| Shimokawa, H | 1 |
| Takeshita, A | 1 |
| Huang, TF | 1 |
| Peng, YI | 1 |
| Huang, LL | 1 |
| Machado, BH | 1 |
| Brody, MJ | 1 |
| Wang, QA | 1 |
| Bauer, RM | 1 |
| Vela, MB | 1 |
| Simon, T | 1 |
| Waldrop, TG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
17 other studies available for gamma-aminobutyric acid and Bradyarrhythmia
| Article | Year |
|---|---|
Early central cardiovagal dysfunction after high fat diet in a murine model.
Topics: Animals; Bradycardia; Diet, High-Fat; Disease Models, Animal; gamma-Aminobutyric Acid; Medulla Oblon | 2023 |
Compounded ointment results in severe toxicity in a pediatric patient.
Topics: Administration, Cutaneous; Amines; Analgesics; Body Surface Area; Bradycardia; Clonidine; Combined M | 2013 |
GABA in nucleus tractus solitarius participates in electroacupuncture modulation of cardiopulmonary bradycardia reflex.
Topics: Animals; Bradycardia; Electroacupuncture; GABA Antagonists; gamma-Aminobutyric Acid; Heart; Kainic A | 2014 |
Modulation of cardiopulmonary depressor reflex in nucleus ambiguus by electroacupuncture: roles of opioids and γ-aminobutyric acid.
Topics: Analgesics, Opioid; Animals; Biguanides; Blood Pressure; Bradycardia; Cardiovascular System; Cats; E | 2012 |
Medullary GABAergic mechanisms contribute to electroacupuncture modulation of cardiovascular depressor responses during gastric distention in rats.
Topics: Acidosis, Respiratory; Animals; Autonomic Nervous System; Blood Pressure; Bradycardia; Cardiovascula | 2013 |
CENTRAL CARDIOVASCULAR ACTIONS OF GAMMA-AMINOBUTYRIC ACID.
Topics: Aminobutyrates; Animals; Bradycardia; Cats; Dogs; gamma-Aminobutyric Acid; Heart; Heart Rate; Hypote | 1964 |
Central nervous system mechanisms involving GABA influence arterial pressure and heart rate in the cat.
Topics: Animals; Autonomic Nervous System; Blood Pressure; Bradycardia; Cats; Central Nervous System; Clonid | 1980 |
Cardiac noradrenergic mechanisms mediate GABA-enhanced ouabain cardiotoxicity.
Topics: Analysis of Variance; Animals; Bradycardia; Dose-Response Relationship, Drug; gamma-Aminobutyric Aci | 1994 |
Preferential hindquarter vasodilation in the hypotension induced by GABA injection into the cisterna magna of conscious rats.
Topics: Animals; Blood Pressure; Bradycardia; gamma-Aminobutyric Acid; Heart Rate; Hypotension; Male; Rats; | 1993 |
GABA may function tonically via GABA(A) receptors to inhibit hypotension and bradycardia by L-DOPA microinjected into depressor sites of the nucleus tractus solitarii in anesthetized rats.
Topics: Anesthesia; Animals; Bicuculline; Binding, Competitive; Bradycardia; Dopamine Agents; Dose-Response | 1999 |
Rostral ventrolateral medulla suppresses reflex bradycardia by the release of gamma-aminobutyric acid in nucleus tractus solitarii of the rat.
Topics: Afferent Pathways; Animals; Baroreflex; Bradycardia; gamma-Aminobutyric Acid; Glutamic Acid; Male; M | 2001 |
Overexpression of eNOS in the RVLM causes hypotension and bradycardia via GABA release.
Topics: Adenoviridae; Animals; beta-Galactosidase; Blood Pressure; Bradycardia; Enzyme Inhibitors; gamma-Ami | 2001 |
GABAergic neurotransmission at the nucleus tractus solitarii in the suppression of reflex bradycardia by parabrachial nucleus.
Topics: Animals; Baroreflex; Bradycardia; Electric Stimulation; GABA Antagonists; gamma-Aminobutyric Acid; M | 2001 |
The effect of microinjection of amino acids into the nucleus tractus solitarius on the diving bradycardia in the rat.
Topics: Amino Acids; Animals; Blood Pressure; Bradycardia; Calcium; Cations; Diving; gamma-Aminobutyric Acid | 1991 |
Role of the nucleus ambiguus in the regulation of heart rate and arterial pressure.
Topics: Animals; Blood Pressure; Bradycardia; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Heart Rate | 1988 |
A GABAergic mechanism in the inhibition of cardiac vagal reflexes.
Topics: Animals; Bradycardia; gamma-Aminobutyric Acid; Heart Conduction System; Medulla Oblongata; Rabbits; | 1988 |
A GABAergic mechanism in the posterior hypothalamus modulates baroreflex bradycardia.
Topics: Animals; Bradycardia; Cats; Electric Stimulation; gamma-Aminobutyric Acid; Hypothalamus; Hypothalamu | 1988 |