gamma-aminobutyric acid and Body Weight studies

gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.

Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.

Research Excerpts

Excerpt	Relevance	Reference
" The study was undertaken to investigate the possible protective and ameliorating effects of GABA in Letrozole induced PCOS model in rats by targeting insulin resistance."	7.85	Protective effects of GABA against metabolic and reproductive disturbances in letrozole induced polycystic ovarian syndrome in rats. ( Afsar, T; Almajwal, A; Jahan, S; Pirzada, M; Rauf, N; Razak, S; Ullah, A; Ullah, H, 2017)
"The action of peripherally released leptin at long-form leptin receptors (LepRb) within the brain represents a fundamental axis in the regulation of energy homeostasis and body weight."	7.78	Neurochemical characterization of body weight-regulating leptin receptor neurons in the nucleus of the solitary tract. ( Evans, ML; Garfield, AS; Gribble, FM; Heisler, LK; Myers, MG; Patterson, C; Reimann, F; Skora, S, 2012)
"Pregabalin (PGB) was licensed in Europe as an add-on antiepileptic drug (AED) for the treatment of partial-onset seizures in 2004."	7.77	Adjunctive pregabalin for uncontrolled partial-onset seizures: findings from a prospective audit. ( Brodie, MJ; Kelly, K; Leach, V; Parker, P; Stephen, LJ; Wilson, EA, 2011)
"The purpose of this study was to investigate whether taurine ameliorate the diabetic retinopathy, and to further explore the underlying mechanisms."	7.74	Dietary taurine supplementation ameliorates diabetic retinopathy via anti-excitotoxicity of glutamate in streptozotocin-induced Sprague-Dawley rats. ( Chen, F; Chen, K; Mi, M; Tang, Y; Wang, J; Wei, N; Xu, H; Xu, Z; Yu, X; Zeng, K; Zhang, Q; Zhu, J, 2008)
"The authors reviewed changes in body weight in 44 patients treated with Gabapentin (GPN) for a period of 12 or more months."	7.69	Changes in body weight with chronic, high-dose gabapentin therapy. ( DeCerce, J; DeToledo, JC; Ramsay, RE; Toledo, C, 1997)
" Since the effects of carbamazepine on substance P content are identical with previously described effects of lithium, an alteration in substance P neurotransmission may be one of the neurochemical bases of common clinical and behavioral effects of carbamazepine and lithium on affective disorders."	7.67	Effects of chronic treatment with trihexyphenidyl and carbamazepine alone or in combination with haloperidol on substance P content in rat brain: a possible implication of substance P in affective disorders. ( Mataga, N; Mitsushio, H; Takashima, M; Toru, M, 1988)
"1 %) and relative bioavailability (F) (26."	5.40	Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014)
"Vigabatrin is an inhibitor of γ-aminobutyric acid transaminase."	5.40	Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014)
"Vigabatrin pharmacokinetic data from six randomized controlled clinical trials and one open-label study were analyzed using nonlinear mixed-effects modeling."	5.40	Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014)
" Covariate analysis indicated that age, creatinine clearance (CLCR), and body weight were important predictors of vigabatrin pharmacokinetic parameters."	5.40	Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014)
"The model adequately described vigabatrin pharmacokinetic and enabled predictions of systemic exposures in pediatric patients 1-12 months of age."	5.40	Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014)
"Of the 135 patients, 14 (10."	5.37	Adjunctive pregabalin for uncontrolled partial-onset seizures: findings from a prospective audit. ( Brodie, MJ; Kelly, K; Leach, V; Parker, P; Stephen, LJ; Wilson, EA, 2011)
"To assess the roles of substance P in neurologic or psychiatric illnesses, effects of acute or chronic (40- or 80-day dietary) treatment with trihexyphenidyl and carbamazepine alone or in combination with haloperidol on substance P content were investigated in the rat brain."	5.27	Effects of chronic treatment with trihexyphenidyl and carbamazepine alone or in combination with haloperidol on substance P content in rat brain: a possible implication of substance P in affective disorders. ( Mataga, N; Mitsushio, H; Takashima, M; Toru, M, 1988)
"Gabapentin was administered in single doses of 10 mg/kg (N=48 healthy subjects, age 1 month-12 years) or in multiple doses of 10-65 mg/kg per day (N=205 patients with epilepsy, age 2 months-13 years) at 08:00, 14:00, and 20:00."	5.09	Population pharmacokinetics of gabapentin in infants and children. ( Bockbrader, HN; Garofalo, E; Ouellet, D; Shapiro, DY; Wesche, DL, 2001)
" Activation of LDTg amylin receptors by the agonist salmon calcitonin dose-dependently reduces body weight, food intake, and motivated feeding behaviors."	3.85	Amylin Acts in the Lateral Dorsal Tegmental Nucleus to Regulate Energy Balance Through Gamma-Aminobutyric Acid Signaling. ( Hahn, JD; Hayes, MR; Kanoski, SE; Koch-Laskowski, K; Krawczyk, J; McGrath, LE; Mietlicki-Baase, EG; Noble, EE; Olivos, DR; Reiner, DJ; Schmidt, HD; Turner, CA; Zimmer, DJ, 2017)
" The study was undertaken to investigate the possible protective and ameliorating effects of GABA in Letrozole induced PCOS model in rats by targeting insulin resistance."	3.85	Protective effects of GABA against metabolic and reproductive disturbances in letrozole induced polycystic ovarian syndrome in rats. ( Afsar, T; Almajwal, A; Jahan, S; Pirzada, M; Rauf, N; Razak, S; Ullah, A; Ullah, H, 2017)
" The results indicated that GABA has an advantage over taurine of anti-fatigue effect."	3.83	Extraction, purification and anti-fatigue activity of γ-aminobutyric acid from mulberry (Morus alba L.) leaves. ( Chen, H; He, Q; He, X; Li, J; Liu, Y; Wang, J; Wei, B; Zhang, C; Zhang, Y, 2016)
" We hypothesized that the body weight setpoint of the DIO-D phenotype resides in the hypothalamic paraventricular nucleus (PVN), where anorexigenic melanocortins, including melanotan II (MTII), increase presynaptic GABA release, and the orexigenic neuropeptide Y (NPY) inhibits it."	3.81	Defense of Elevated Body Weight Setpoint in Diet-Induced Obese Rats on Low Energy Diet Is Mediated by Loss of Melanocortin Sensitivity in the Paraventricular Hypothalamic Nucleus. ( Baracos, VE; Chee, MJ; Colmers, WF; Doslikova, B; Luchtman, DW; Marks, DL, 2015)
" The physiological state (body weight and plasma corticosterone concentrations), emotion, cognitive behavior, brain morphology, apoptosis, and balance of gamma-aminobutyric acid (GABA) and glutamate in the hippocampus and prefrontal cortex were observed."	3.80	Glutamate and GABA imbalance promotes neuronal apoptosis in hippocampus after stress. ( Chen, C; Gao, J; Li, S; Li, YY; Liu, LM; Liu, Y; Wang, H; Wu, YM; Yang, C, 2014)
"The action of peripherally released leptin at long-form leptin receptors (LepRb) within the brain represents a fundamental axis in the regulation of energy homeostasis and body weight."	3.78	Neurochemical characterization of body weight-regulating leptin receptor neurons in the nucleus of the solitary tract. ( Evans, ML; Garfield, AS; Gribble, FM; Heisler, LK; Myers, MG; Patterson, C; Reimann, F; Skora, S, 2012)
"Isoflurane anesthesia was physiologically well tolerated by the dams."	3.77	Rats exposed to isoflurane in utero during early gestation are behaviorally abnormal as adults. ( Baxter, MG; Crosby, G; Culley, DJ; Keel, PK; Palanisamy, A; Xie, Z, 2011)
"Rats exposed to isoflurane in utero at a time that corresponds to the second trimester in humans have impaired spatial memory acquisition and reduced anxiety, compared with controls."	3.77	Rats exposed to isoflurane in utero during early gestation are behaviorally abnormal as adults. ( Baxter, MG; Crosby, G; Culley, DJ; Keel, PK; Palanisamy, A; Xie, Z, 2011)
"Pregabalin (PGB) was licensed in Europe as an add-on antiepileptic drug (AED) for the treatment of partial-onset seizures in 2004."	3.77	Adjunctive pregabalin for uncontrolled partial-onset seizures: findings from a prospective audit. ( Brodie, MJ; Kelly, K; Leach, V; Parker, P; Stephen, LJ; Wilson, EA, 2011)
"A total of 60 pregnant mice, divided into 12 groups of five mice each, were exposed to gabapentin in four different doses of 0 (control), 113, 226, or 452 mg/kg body weight per day, at three different gestational stages including early gestation (1-6 days), mid-gestation (7-12 days), and late gestation (13-17 days)."	3.74	Teratogenic effects of the anticonvulsant gabapentin in mice. ( Goel, RK; Madhyastha, S; Nasar, MA; Pai, MM; Prabhu, LV; Rai, R; Singh, G; Yadav, SK, 2008)
"The purpose of this study was to investigate whether taurine ameliorate the diabetic retinopathy, and to further explore the underlying mechanisms."	3.74	Dietary taurine supplementation ameliorates diabetic retinopathy via anti-excitotoxicity of glutamate in streptozotocin-induced Sprague-Dawley rats. ( Chen, F; Chen, K; Mi, M; Tang, Y; Wang, J; Wei, N; Xu, H; Xu, Z; Yu, X; Zeng, K; Zhang, Q; Zhu, J, 2008)
"The aim of this study was to assess the effects of prenatal exposures to cannabinoids or carbon monoxide (CO) in an animal experimental model reproducing the environmental conditions in which a fetus develops whose mother, during pregnancy, ingests by smoking low doses of cannabinoids or CO."	3.74	Effects of prenatal exposure to the CB-1 receptor agonist WIN 55212-2 or CO on the GABAergic neuronal systems of rat cerebellar cortex. ( Ambrosi, G; Auteri, P; Benagiano, V; Bosco, L; Cagiano, R; Flace, P; Girolamo, F; Lorusso, L; Rizzi, A; Sabatini, R, 2007)
"We aim to study and elucidate the safety profile of the antiepileptic doses of gabapentin during pregnancy, and to evaluate gabapentin-induced murine fetotoxicity at different dose levels."	3.74	Teratogenic effects of the anticonvulsant gabapentin in mice. ( Goel, RK; Madhyastha, S; Nasar, MA; Pai, MM; Prabhu, LV; Rai, R; Singh, G; Yadav, SK, 2008)
"Gabapentin should not be prescribed during pregnancy, as no therapeutic dose of gabapentin is safe during this period as far as the foetal well-being is concerned."	3.74	Teratogenic effects of the anticonvulsant gabapentin in mice. ( Goel, RK; Madhyastha, S; Nasar, MA; Pai, MM; Prabhu, LV; Rai, R; Singh, G; Yadav, SK, 2008)
"several parameters, concerning fertility were measured in 40 albino male rats of Sprague Dawley strain, they were divided into 4 groups, group one received vehicle (distilled water), group two received Vigabatrin in a dose of 200 mg/kg body weight, group three received Lamotrigine in a dose of 30 mg/kg body weight, and group four received Gabapentin 100 mg/kg body weight."	3.72	The effect of Vigabatrin, Lamotrigine and Gabapentin on the fertility, weights, sex hormones and biochemical profiles of male rats. ( Abdul-Zahra, E; Bataineh, H; Daoud, AS; Otoom, S, 2004)
"The authors reviewed changes in body weight in 44 patients treated with Gabapentin (GPN) for a period of 12 or more months."	3.69	Changes in body weight with chronic, high-dose gabapentin therapy. ( DeCerce, J; DeToledo, JC; Ramsay, RE; Toledo, C, 1997)
"The effect of caloric deprivation to stimulate hypothalamic neuropeptide Y (NPY) gene expression is hypothesized to represent a physiologically important adaptation in body weight homeostasis."	3.68	Differential effect of fasting on hypothalamic expression of genes encoding neuropeptide Y, galanin, and glutamic acid decarboxylase. ( Baskin, DG; Grubin, CE; Schwartz, MW; Sipols, AJ, 1993)
"Wistar rat pups were administered either a high dose of lead acetate (400 micrograms lead/g body weight/day) or a low dose (100 micrograms lead/g body weight/day) by gastric intubation, from 2 days through 60 days of age."	3.68	Regional alterations of brain biogenic amines and GABA/glutamate levels in rats following chronic lead exposure during neonatal development. ( Desiraju, T; Shailesh Kumar, MV, 1990)
"The effect of maternal alcohol consumption during pregnancy and lactation on gamma-aminobutyric acid (GABA) levels in different rat brain regions of 3-week-old pups was investigated."	3.67	Effect of pre- and postnatal alcohol consumption on GABA levels of various brain regions in the rat offspring. ( Ciesielski, L; Ledig, M; Lorentz, JG; Mandel, P; Simler, S, 1988)
" Since the effects of carbamazepine on substance P content are identical with previously described effects of lithium, an alteration in substance P neurotransmission may be one of the neurochemical bases of common clinical and behavioral effects of carbamazepine and lithium on affective disorders."	3.67	Effects of chronic treatment with trihexyphenidyl and carbamazepine alone or in combination with haloperidol on substance P content in rat brain: a possible implication of substance P in affective disorders. ( Mataga, N; Mitsushio, H; Takashima, M; Toru, M, 1988)
"The role of gamma-aminobutyric acid (GABA) in the abnormal secretion of thyrotropic hormone (TSH) in uremia was studied in male Sprague-Dawley rats rendered renally insufficient by subtotal nephrectomy."	3.67	Gamma-aminobutyric acid and dysregulation of TSH secretion in uremic male rats. ( Ansari, MA; Elias, AN; Iyer, K; Pandian, MR; Vaziri, ND, 1987)
" Intersubject variability was approximately 30% for oral clearance and volume of distribution and was larger for the absorption rate constant and lag time."	2.70	Population pharmacokinetics of gabapentin in infants and children. ( Bockbrader, HN; Garofalo, E; Ouellet, D; Shapiro, DY; Wesche, DL, 2001)
"Gabapentin was administered in single doses of 10 mg/kg (N=48 healthy subjects, age 1 month-12 years) or in multiple doses of 10-65 mg/kg per day (N=205 patients with epilepsy, age 2 months-13 years) at 08:00, 14:00, and 20:00."	2.70	Population pharmacokinetics of gabapentin in infants and children. ( Bockbrader, HN; Garofalo, E; Ouellet, D; Shapiro, DY; Wesche, DL, 2001)
"Trimegestone (TMG) is a novel, 19-norpregnane progestin with potent and selective properties."	2.44	Preclinical and clinical properties of trimegestone: a potent and selective progestin. ( Bossemeyer, R; Bouchard, P; Sitruk-Ware, R, 2007)
"Palmatine plays a significant role in sedation and hypnosis, which may be associated with the increase of intra-cerebral 5-HT."	1.51	Palmatine plays a role in sedation and hypnosis by increasing 5-hydroxytryptamine. ( Du, J; Qiu, L; Qiu, M; Yu, Y; Zhu, Q, 2019)
"The mechanism responsible for the anti-seizure effect of ketogenic diets is poorly understood."	1.43	Ketogenic diet prevents neuronal firing increase within the substantia nigra during pentylenetetrazole-induced seizure in rats. ( Coppola, G; Iovane, V; Monda, M; Operto, FF; Pisano, S; Stoddard, M; Viggiano, A, 2016)
"However, PTSD-related pathological changes in the hippocampus and prefrontal cortex remain poorly understood."	1.40	Glutamate and GABA imbalance promotes neuronal apoptosis in hippocampus after stress. ( Chen, C; Gao, J; Li, S; Li, YY; Liu, LM; Liu, Y; Wang, H; Wu, YM; Yang, C, 2014)
"We investigated the effect of a PTSD-like animal model induced by severe stress."	1.40	Glutamate and GABA imbalance promotes neuronal apoptosis in hippocampus after stress. ( Chen, C; Gao, J; Li, S; Li, YY; Liu, LM; Liu, Y; Wang, H; Wu, YM; Yang, C, 2014)
"Koumine treatment of diabetic rats decreased neuropathic pain behavior as early as after the first administration."	1.40	Anti-allodynic and neuroprotective effects of koumine, a Benth alkaloid, in a rat model of diabetic neuropathy. ( Huang, HH; Ling, Q; Liu, M; Wu, MX; Xu, Y; Yang, J; Yu, CX, 2014)
"Koumine was given at a dose range of 0."	1.40	Anti-allodynic and neuroprotective effects of koumine, a Benth alkaloid, in a rat model of diabetic neuropathy. ( Huang, HH; Ling, Q; Liu, M; Wu, MX; Xu, Y; Yang, J; Yu, CX, 2014)
"Diabetic rats developed mechanical hyperalgesia within 3 weeks after streptozocin injection and exhibited reduced SNCV and impaired myelin/axonal structure."	1.40	Anti-allodynic and neuroprotective effects of koumine, a Benth alkaloid, in a rat model of diabetic neuropathy. ( Huang, HH; Ling, Q; Liu, M; Wu, MX; Xu, Y; Yang, J; Yu, CX, 2014)
" Covariate analysis indicated that age, creatinine clearance (CLCR), and body weight were important predictors of vigabatrin pharmacokinetic parameters."	1.40	Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014)
"The model adequately described vigabatrin pharmacokinetic and enabled predictions of systemic exposures in pediatric patients 1-12 months of age."	1.40	Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014)
"1 %) and relative bioavailability (F) (26."	1.40	Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014)
"Vigabatrin is an inhibitor of γ-aminobutyric acid transaminase."	1.40	Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014)
"Reproductive endocrine disturbances are a major health concern in women with epilepsy due to their long term use of antiepileptic drugs (AEDs)."	1.40	Second generation anti-epileptic drugs adversely affect reproductive functions in young non-epileptic female rats. ( Kaur, G; Kumar, S, 2014)
"Vigabatrin pharmacokinetic data from six randomized controlled clinical trials and one open-label study were analyzed using nonlinear mixed-effects modeling."	1.40	Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014)
" Blockade of serotonin (5-HT(3)) receptor signalling in the NTS by either the chronic administration of ondansetron or the genetic inactivation of Tph2 in caudal serotonergic neurons that project to the NTS protects against starvation when AgRP neurons are ablated."	1.38	Deciphering a neuronal circuit that mediates appetite. ( Clark, MS; Palmiter, RD; Wu, Q, 2012)
"Huntington's disease is a progressive neurodegenerative disorder that gradually reduces memory, cognitive skills and normal movements of affected individuals."	1.38	Possible GABAergic mechanism in the neuroprotective effect of gabapentin and lamotrigine against 3-nitropropionic acid induced neurotoxicity. ( Kalonia, H; Kumar, A; Kumar, P, 2012)
"Isoflurane anesthesia was physiologically well tolerated by the dams."	1.37	Rats exposed to isoflurane in utero during early gestation are behaviorally abnormal as adults. ( Baxter, MG; Crosby, G; Culley, DJ; Keel, PK; Palanisamy, A; Xie, Z, 2011)
"Of the 135 patients, 14 (10."	1.37	Adjunctive pregabalin for uncontrolled partial-onset seizures: findings from a prospective audit. ( Brodie, MJ; Kelly, K; Leach, V; Parker, P; Stephen, LJ; Wilson, EA, 2011)
" In the present retrospective study we evaluated the impact of these vendor changes on ketamine dosing to establish anaesthesia, on pilocarpine-induced seizure susceptibility, and on basal extracellular hippocampal noradrenaline, dopamine, serotonin, gamma-amino butyric acid, and glutamate levels of all pilocarpine-treated rats included in our studies."	1.35	Intrastrain differences in seizure susceptibility, pharmacological response and basal neurochemistry of Wistar rats. ( Aourz, N; Clinckers, R; De Bundel, D; Meurs, A; Michotte, Y; Portelli, J; Smolders, I, 2009)
"Ketosis was quantified as 24-h ketonuria."	1.34	Ketogenic diet: electrophysiological effects on the normal human cortex. ( Bellomo, G; Cantello, R; Cecchin, M; D'Andrea, F; Monaco, F; Tarletti, R; Varrasi, C; Veggiotti, P, 2007)
"It has been hypothesized that alcohol addiction is mediated, at least in part, by specific gamma-aminobutyric acid(A) (GABA(A)) receptors within the ventral pallidum (VP)."	1.32	The reinforcing properties of alcohol are mediated by GABA(A1) receptors in the ventral pallidum. ( Carroll, MR; Cook, JM; Cummings, R; Eiler, WJ; Foster, KL; Garcia, M; Grey, C; Harvey, SC; Jones, CM; June, HL; Ma, C; Mason, D; McCane, S; McKay, PF; Sarma, PV; Seyoum, R; Skolnick, P; Woods, JE; Yin, W, 2003)
"Very low birth weight (VLBW) and fetal growth restriction are associated with increased risks of long-term visual impairments, including alterations to contrast sensitivity, a parameter mediated in part by dopaminergic amacrine cells."	1.32	Chronic placental insufficiency affects retinal development in the guinea pig. ( Briscoe, T; Caddy, J; Dieni, S; Lambert, G; Loeliger, M; Rees, S; Rehn, A, 2004)
"The rats with acute renal failure showed arrested body weight gain and an increase of kidney weight, whereas oral administration of GABA attenuated the physiological changes induced by acute renal failure."	1.32	Protective effect of gamma-aminobutyric acid against glycerol-induced acute renal failure in rats. ( Kim, HY; Nakagawa, T; Sasaki, S; Yokozawa, T, 2004)
" During the chronic administration of experimental diets to SHR/Izm, a significantly slower increase in blood pressure with respect to the control group was observed at 1 or 2 weeks after the start of feeding with the GABA or FMG diet respectively (P<0."	1.32	Effect of a gamma-aminobutyric acid-enriched dairy product on the blood pressure of spontaneously hypertensive and normotensive Wistar-Kyoto rats. ( Hayakawa, K; Kasaha, K; Kimura, M; Matsumoto, K; Sansawa, H; Yamori, Y, 2004)
"In diazepam-treated rats, GABA content of the hypothalamus was unaffected by stresses but that of the hippocampus was slightly decreased."	1.31	Diazepam-like effects of a fish protein hydrolysate (Gabolysat PC60) on stress responsiveness of the rat pituitary-adrenal system and sympathoadrenal activity. ( Bernet, F; Dupouy, JP; Montel, V; Noël, B, 2000)
"Heptachlor is a cyclodiene pesticide that was widely used for many years, and for which inadvertent exposure to children and fetuses took place in the early 1980s; yet little is known regarding the developmental neurotoxicity of it and other cyclodienes."	1.31	Neurotoxicological outcomes of perinatal heptachlor exposure in the rat. ( Chapin, RE; Harris, MW; Meacham, CA; Moser, VC; Shafer, TJ; Ward, TR, 2001)
"The relationship between ketosis and brain amino acid metabolism was studied in mice that consumed a ketogenic diet (>90% of calories as lipid)."	1.31	Brain amino acid metabolism and ketosis. ( Daikhin, Y; Lazarow, A; Nissim, I; Yudkoff, M, 2001)
" Pregnant Sprague-Dawley dams were dosed from gestational day (GD) 12 to postnatal day (PND) 7, whereupon the rat pups were dosed directly until PND 21 (group A) or PND 42 (group B)."	1.31	Neurotoxicological outcomes of perinatal heptachlor exposure in the rat. ( Chapin, RE; Harris, MW; Meacham, CA; Moser, VC; Shafer, TJ; Ward, TR, 2001)
" Male Sprague-Dawley rats were dosed orally for 3 months with normal saline or JS at 0."	1.31	Neurotransmitter levels in brains of chronically Jiawey Siwu-treated rats. ( Chen, CC; Chu, CP; Jian, ZH; Lu, HY; Lu, MS; Ng, YY; Yu, S, 2002)
"Gabapentin was without effect in controls but suppressed (P < 0."	1.30	Gabapentin prevents hyperalgesia during the formalin test in diabetic rats. ( Calcutt, NA; Ceseña, RM, 1999)
"Animal models of fetal alcohol syndrome have been developed and used to examine the consequences of prenatal ethanol exposure on the central nervous system."	1.30	Effects of prenatal ethanol exposure on parvalbumin-expressing GABAergic neurons in the adult rat medial septum. ( Heaton, MB; Moore, DB; Ruygrok, AC; Walker, DW, 1997)
"Gabapentin displays efficacy against abnormal sensory processing in diabetic rats and may be of benefit for treating painful diabetic neuropathy."	1.30	Gabapentin prevents hyperalgesia during the formalin test in diabetic rats. ( Calcutt, NA; Ceseña, RM, 1999)
" Oral dosing [3 mg/ml of drinking water, giving doses of GVG of 194 +/- 38 mg/kg/day and of EOS of 303 +/- 42 mg/kg/day (mean +/- SD)] was followed by microdialysis at 2, 8, and 21 days."	1.29	The effect of chronic treatment with the GABA transaminase inhibitors gamma-vinyl-GABA and ethanolamine-O-sulphate on the in vivo release of GABA from rat hippocampus. ( Fowler, LJ; Qume, M; Whitton, PS, 1995)
"Acute and chronic administration of vigabatrin, a selective inactivator of GABA-T, suppresses haloperidol-induced dyskinesias at low doses without preventing the enhancement of striatal dopamine D2 receptor density or the development of vacuous chewing movements."	1.29	Suppression of haloperidol-induced oral dyskinesias in rats by vigabatrin. ( Elands, J; Gobaille, S; Grauffel, C; Knödgen, B; Moran, P; Sarhan, S; Seiler, N; van den Buuse, M, 1995)
" Testicular weight was significantly lower in the group of rats treated with the low dosage of GAG (5 mg/kg), and serum prolactin was significantly lower in the rats treated with the high dosage of GAG (20 mg/kg) as compared with control rats."	1.27	Prolonged treatment with gamma-aminobutyric acid (GABA)-mimetic substances in prepubertal male rats. ( Debeljuk, L; Díaz, MD; Maines, VM; Seilicovich, A, 1983)
"In the second experiment, GBL-treated rats had body weights similar to those of control rats, but testicular weights were significantly decreased."	1.27	Prolonged treatment with gamma-aminobutyric acid (GABA)-mimetic substances in prepubertal male rats. ( Debeljuk, L; Díaz, MD; Maines, VM; Seilicovich, A, 1983)
"Bicuculline pretreatment, however, did not alter the basal secretion of TSH in either the normal or the uremic animals, and it also did not augment the TRH-stimulated TSH response in the normal animals."	1.27	Gamma-aminobutyric acid and dysregulation of TSH secretion in uremic male rats. ( Ansari, MA; Elias, AN; Iyer, K; Pandian, MR; Vaziri, ND, 1987)
"To assess the roles of substance P in neurologic or psychiatric illnesses, effects of acute or chronic (40- or 80-day dietary) treatment with trihexyphenidyl and carbamazepine alone or in combination with haloperidol on substance P content were investigated in the rat brain."	1.27	Effects of chronic treatment with trihexyphenidyl and carbamazepine alone or in combination with haloperidol on substance P content in rat brain: a possible implication of substance P in affective disorders. ( Mataga, N; Mitsushio, H; Takashima, M; Toru, M, 1988)
" Similar studies were conducted with rats treated at the highest lead dosage which did not result in weight loss (100 microgram lead as lead acetate/g body weight/day via intubation)."	1.26	Developmental studies of the uptake of choline, GABA and dopamine by crude synaptosomal preparations after in vivo or in vitro lead treatment. ( Krigman, MR; Morell, P; Ramsay, PB, 1980)
"Choline uptake was very low until 12 days postnatally, then the Vmax increased and approached adult values of 29 pmol/mg prot."	1.26	Developmental studies of the uptake of choline, GABA and dopamine by crude synaptosomal preparations after in vivo or in vitro lead treatment. ( Krigman, MR; Morell, P; Ramsay, PB, 1980)

Research

Studies (194)

Authors

Clinical Trials (5)

Trial Overview

Trial Outcomes

"VAS Score 1: How Much Pain do You Feel in Your Operative Site When Resting?"

Timeframe	Studies, this research(%)	All Research%
pre-1990	32 (16.49)	18.7374
1990's	29 (14.95)	18.2507
2000's	71 (36.60)	29.6817
2010's	53 (27.32)	24.3611
2020's	9 (4.64)	2.80

Authors	Studies
Yong, Y	1
Cakir, I	1
Lining Pan, P	1
Biddinger, JE	1
Bluett, RJ	1
Mackie, K	1
Bingham, N	1
Patel, S	1
Ghamari-Langroudi, M	1
Hosseini Dastgerdi, A	1
Sharifi, M	1
Soltani, N	1
Li, X	2
Song, X	1
Fang, L	1
Ding, J	1
Qi, L	1
Wang, Q	2
Dong, C	1
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Wang, T	1
Wu, Q	2
Zhang, M	2
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Zhang, K	1
Shi, Z	1
Lv, M	1
Wang, F	1
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Yanaka, N	1
Du, J	1
Yu, Y	1
Qiu, L	1
Qiu, M	1
Zhu, Q	1
Fontaine, CJ	1
Pinar, C	1
Yang, W	1
Pang, AF	1
Suesser, KE	1
Choi, JSJ	1
Christie, BR	1
Lee, DW	1
Nam, YK	1
Kim, TK	1
Kim, JH	1
Kim, SY	1
Min, JW	1
Lee, JH	1
Kim, HY	2
Kim, DJ	1
Choe, BY	1
Takeshima, K	1
Yamatsu, A	1
Yamashita, Y	1
Watabe, K	1
Horie, N	1
Masuda, K	1
Kim, M	2
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Liu, Y	2
Li, YY	1
Chen, C	1
Liu, LM	1
Wu, YM	1
Li, S	1
Yang, C	1
Tzanoulinou, S	1
García-Mompó, C	1
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Veenit, V	1
Nacher, J	1
Sandi, C	1
Ling, Q	1
Liu, M	1
Wu, MX	1
Xu, Y	2
Yang, J	2
Huang, HH	1
Yu, CX	1
Evans, MC	1
Rizwan, MZ	1
Anderson, GM	2
Nielsen, JC	1
Kowalski, KG	1
Karim, A	1
Patel, M	1
Wesche, DL	2
Tolbert, D	1
Kumar, S	1
Kaur, G	1
Xie, ZX	1
Xia, SF	1
Qiao, Y	1
Shi, YH	1
Le, GW	1
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Olivos, DR	1
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Noble, EE	1
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Schmidt, HD	1
Kanoski, SE	1
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Meurers, BH	1
Zhu, C	1
Fernagut, PO	1
Richter, F	1
Hsia, YC	1
Fleming, SM	1
Oh, M	1
Elashoff, D	1
Dicarlo, CD	1
Seaman, RL	1
Chesselet, MF	1
Ackermann, TF	1
Hörtnagl, H	1
Wolfer, DP	1
Colacicco, G	1
Sohr, R	1
Lang, F	1
Hellweg, R	1
Lang, UE	1
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Elmquist, JK	1
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Matsunaga, M	1
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Smolders, I	1
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Clinckers, R	1
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Furukawa, F	1
Suguro, M	1
Ito, H	1
Imai, N	1
Nabae, K	1
Toda, Y	1
Inatomi, S	1
Kinugasa, S	1
Kobayashi, H	1
Hokazono, H	1
Omori, T	1
Ono, K	1
Roberto, M	1
Cruz, MT	1
Gilpin, NW	1
Sabino, V	1
Schweitzer, P	1
Bajo, M	1
Cottone, P	1
Madamba, SG	1
Stouffer, DG	1
Zorrilla, EP	1
Koob, GF	1
Siggins, GR	1
Parsons, LH	1
Bellocchio, L	1
Lafenêtre, P	1
Cannich, A	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
Role of the Gut Microbiome as Determinant of Depression in Multiple Sclerosis Subjects[NCT05808101]		120 participants (Anticipated)	Observational	2022-01-27	Recruiting
Comparison of Oral Gabapentin and Pregabalin in Postoperative Pain Control After Photorefractive Keratectomy: a Prospective, Randomized Study.[NCT00954187]		8 participants (Actual)	Interventional	2009-11-30	Terminated (stopped due to PI left institution)
Gabapentin Regimens and Their Effects on Opioid Consumption[NCT03334903]	Phase 4	77 participants (Actual)	Interventional	2018-05-15	Completed
Gabapentin as a Pre-emptive Analgesic in Oral and Maxillofacial Surgical Procedures[NCT02957097]	Phase 4	0 participants (Actual)	Interventional	2019-09-30	Withdrawn (stopped due to Original PI left institution and the PI who took over was not able to initiate the study so it was never started.)
The Effect of Gabapentin on Acute Pain and PONV in Bariatric Surgical Patients[NCT00886236]		62 participants (Actual)	Interventional	2008-02-29	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Surgical site pain. Scale 0-10, with 0 best and 10 worst (NCT03334903)
Timeframe: 2-3 months after surgery (at 2nd postoperative appointment)

"VAS Score 2: How Much Pain do You Feel in Your Operative Site When Moving?"

Intervention	score on 10-point scale (Mean)
Standard of Care	2.26
Postoperative Gabapentin Regimen	2.46

Surgical site pain. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

"VAS Score 3: How Well Are You Sleeping?"

Intervention	score on a 10-point scale (Mean)
Standard of Care	3.84
Postoperative Gabapentin Regimen	3.54

Sleep quality. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

"VAS Score 4: How Bad is Your Nausea?"

Intervention	score on a 10-point scale (Mean)
Standard of Care	5.73
Postoperative Gabapentin Regimen	6.38

Nausea. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

"VAS Score 5: How Satisfied Are You With Your Pain Management?"

Intervention	score on a 10-point scale (Mean)
Standard of Care	0.36
Postoperative Gabapentin Regimen	0.17

Satisfaction. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Days Taking Opioids

Intervention	score on a 10-point scale (Mean)
Standard of Care	7.83
Postoperative Gabapentin Regimen	8.48

Number of days until patients are finished consuming opioid medications after discharge. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Opioid Consumption

Intervention	days (Mean)
Standard of Care	14.8
Postoperative Gabapentin Regimen	18.7

Mean opioid consumption, measured in mg of morphine equivalents. (NCT03334903)
Timeframe: 2-3 months following surgery (total amount measured at second postoperative appointment; means assessed afterwards).

Evaluate Incidence of Respiratory Depression as Evidenced by Pulse Oximetry Data

Evaluate the Amount of Diluadid Given Postoperatively

Intervention	morphine equivalents (Mean)
Standard of Care	287.0
Postoperative Gabapentin Regimen	281.1

Intervention	% oxygen saturation (Mean)
1 Preoperative Gabapentin Liquid	93
2 Preoperative and Postoperative Gabapentin Liquid	94
3 Preoperative and Postoperative Placebo Liquid	95

The amount of intraoperative and postoperative opioids used will be collected and analyzed for the three different arms. (NCT00886236)
Timeframe: 120 hours

Article	Year
Glutamate and GABA in lateral hypothalamic mechanisms controlling food intake. Physiology & behavior, 2011, Jul-25, Volume: 104, Issue:1 Topics: Animals; Body Weight; Eating; Feeding Behavior; gamma-Aminobutyric Acid; Glutamic Acid; Hypothalamic	2011
Characterizing and understanding body weight patterns in patients treated with pregabalin. Current medical research and opinion, 2012, Volume: 28, Issue:6 Topics: Adult; Aged; Anticonvulsants; Body Weight; Comprehension; Diabetic Neuropathies; Epilepsies, Partial	2012
Overlapping and interactive pathways regulating appetite and craving. Journal of addictive diseases, 2004, Volume: 23, Issue:3 Topics: Adipose Tissue; Appetite Regulation; Body Weight; Cannabinoid Receptor Modulators; Energy Intake; ga	2004
Hap1 and GABA: thinking about food intake. Cell metabolism, 2006, Volume: 3, Issue:6 Topics: Animals; Body Weight; Eating; Feeding and Eating Disorders; gamma-Aminobutyric Acid; Hypothalamus; N	2006
Preclinical and clinical properties of trimegestone: a potent and selective progestin. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2007, Volume: 23, Issue:6 Topics: Affect; Animals; Body Weight; Central Nervous System; Chemical Phenomena; Chemistry; Depression; Dru	2007

Article	Year
Evaluation of the optimal preemptive dose of gabapentin for postoperative pain relief after lumbar diskectomy: a randomized, double-blind, placebo-controlled study. Journal of neurosurgical anesthesiology, 2005, Volume: 17, Issue:2 Topics: Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Body Weight; Cyclohexa	2005
Evaluation of the optimal preemptive dose of gabapentin for postoperative pain relief after lumbar diskectomy: a randomized, double-blind, placebo-controlled study. Journal of neurosurgical anesthesiology, 2005, Volume: 17, Issue:2 Topics: Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Body Weight; Cyclohexa	2005
Evaluation of the optimal preemptive dose of gabapentin for postoperative pain relief after lumbar diskectomy: a randomized, double-blind, placebo-controlled study. Journal of neurosurgical anesthesiology, 2005, Volume: 17, Issue:2 Topics: Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Body Weight; Cyclohexa	2005
Evaluation of the optimal preemptive dose of gabapentin for postoperative pain relief after lumbar diskectomy: a randomized, double-blind, placebo-controlled study. Journal of neurosurgical anesthesiology, 2005, Volume: 17, Issue:2 Topics: Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Body Weight; Cyclohexa	2005
Evaluation of the optimal preemptive dose of gabapentin for postoperative pain relief after lumbar diskectomy: a randomized, double-blind, placebo-controlled study. Journal of neurosurgical anesthesiology, 2005, Volume: 17, Issue:2 Topics: Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Body Weight; Cyclohexa	2005
Evaluation of the optimal preemptive dose of gabapentin for postoperative pain relief after lumbar diskectomy: a randomized, double-blind, placebo-controlled study. Journal of neurosurgical anesthesiology, 2005, Volume: 17, Issue:2 Topics: Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Body Weight; Cyclohexa	2005
Evaluation of the optimal preemptive dose of gabapentin for postoperative pain relief after lumbar diskectomy: a randomized, double-blind, placebo-controlled study. Journal of neurosurgical anesthesiology, 2005, Volume: 17, Issue:2 Topics: Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Body Weight; Cyclohexa	2005
Evaluation of the optimal preemptive dose of gabapentin for postoperative pain relief after lumbar diskectomy: a randomized, double-blind, placebo-controlled study. Journal of neurosurgical anesthesiology, 2005, Volume: 17, Issue:2 Topics: Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Body Weight; Cyclohexa	2005
Evaluation of the optimal preemptive dose of gabapentin for postoperative pain relief after lumbar diskectomy: a randomized, double-blind, placebo-controlled study. Journal of neurosurgical anesthesiology, 2005, Volume: 17, Issue:2 Topics: Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Body Weight; Cyclohexa	2005
Evaluation of the optimal preemptive dose of gabapentin for postoperative pain relief after lumbar diskectomy: a randomized, double-blind, placebo-controlled study. Journal of neurosurgical anesthesiology, 2005, Volume: 17, Issue:2 Topics: Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Body Weight; Cyclohexa	2005
Evaluation of the optimal preemptive dose of gabapentin for postoperative pain relief after lumbar diskectomy: a randomized, double-blind, placebo-controlled study. Journal of neurosurgical anesthesiology, 2005, Volume: 17, Issue:2 Topics: Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Body Weight; Cyclohexa	2005
Evaluation of the optimal preemptive dose of gabapentin for postoperative pain relief after lumbar diskectomy: a randomized, double-blind, placebo-controlled study. Journal of neurosurgical anesthesiology, 2005, Volume: 17, Issue:2 Topics: Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Body Weight; Cyclohexa	2005
Evaluation of the optimal preemptive dose of gabapentin for postoperative pain relief after lumbar diskectomy: a randomized, double-blind, placebo-controlled study. Journal of neurosurgical anesthesiology, 2005, Volume: 17, Issue:2 Topics: Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Body Weight; Cyclohexa	2005
Evaluation of the optimal preemptive dose of gabapentin for postoperative pain relief after lumbar diskectomy: a randomized, double-blind, placebo-controlled study. Journal of neurosurgical anesthesiology, 2005, Volume: 17, Issue:2 Topics: Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Body Weight; Cyclohexa	2005
Evaluation of the optimal preemptive dose of gabapentin for postoperative pain relief after lumbar diskectomy: a randomized, double-blind, placebo-controlled study. Journal of neurosurgical anesthesiology, 2005, Volume: 17, Issue:2 Topics: Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Body Weight; Cyclohexa	2005
Evaluation of the optimal preemptive dose of gabapentin for postoperative pain relief after lumbar diskectomy: a randomized, double-blind, placebo-controlled study. Journal of neurosurgical anesthesiology, 2005, Volume: 17, Issue:2 Topics: Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Body Weight; Cyclohexa	2005
Population pharmacokinetics of gabapentin in infants and children. Epilepsy research, 2001, Volume: 47, Issue:3 Topics: Acetates; Adolescent; Amines; Anticonvulsants; Body Weight; Child; Child, Preschool; Creatinine; Cyc	2001

Article	Year
Endogenous cannabinoids are required for MC4R-mediated control of energy homeostasis. Proceedings of the National Academy of Sciences of the United States of America, 2021, 10-19, Volume: 118, Issue:42 Topics: Animals; Arachidonic Acids; Body Weight; Cannabinoids; Endocannabinoids; Energy Metabolism; Fasting;	2021
GABA administration improves liver function and insulin resistance in offspring of type 2 diabetic rats. Scientific reports, 2021, 11-30, Volume: 11, Issue:1 Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Endocrinology; Female; gamma-A	2021
Body Weight-Supported Treadmill Training Ameliorates Motoneuronal Hyperexcitability by Increasing GAD-65/67 and KCC2 Expression via TrkB Signaling in Rats with Incomplete Spinal Cord Injury. Neurochemical research, 2022, Volume: 47, Issue:6 Topics: Animals; Body Weight; Brain-Derived Neurotrophic Factor; gamma-Aminobutyric Acid; Immunoglobulin G;	2022
Tong-Xie-Yao-Fang alleviates diarrhea-predominant irritable bowel syndrome in rats via the GCN2/PERK-eIF2α-ATF4 signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Volume: 107 Topics: Activating Transcription Factor 4; Animals; Body Weight; Caspase 3; Cysteine; Diarrhea; Drugs, Chine	2022
Gamma-aminobutyric acid-producing lactobacilli positively affect metabolism and depressive-like behaviour in a mouse model of metabolic syndrome. Scientific reports, 2019, 11-08, Volume: 9, Issue:1 Topics: Adipose Tissue; Animals; Behavior, Animal; Body Weight; Cholesterol; Corticosterone; Depression; Dis	2019
Gamma-Aminobutyric Acid Increases Erythropoietin by Activation of Citrate Cycle and Stimulation of Hypoxia-Inducible Factors Expression in Rats. Biomolecules, 2020, 04-12, Volume: 10, Issue:4 Topics: Adenosine Triphosphate; Animals; Basic Helix-Loop-Helix Transcription Factors; Body Weight; Citric A	2020
Effects of GABA Supplementation on Intestinal SIgA Secretion and Gut Microbiota in the Healthy and ETEC-Infected Weanling Piglets. Mediators of inflammation, 2020, Volume: 2020 Topics: Amino Acids; Animals; Bacterial Proteins; Bacteroidetes; Body Weight; Dietary Supplements; Enterococ	2020
Disruption of GABA or glutamate release from POMC neurons in the adult mouse does not affect metabolic end points. American journal of physiology. Regulatory, integrative and comparative physiology, 2020, 11-01, Volume: 319, Issue:5 Topics: Animals; Body Weight; Diet, High-Fat; Energy Metabolism; Female; gamma-Aminobutyric Acid; Gene Expre	2020
Nitrate and nitrite exposure leads to mild anxiogenic-like behavior and alters brain metabolomic profile in zebrafish. PloS one, 2020, Volume: 15, Issue:12 Topics: Animals; Anxiety; Arachidonic Acid; Association Learning; Behavior, Animal; Body Size; Body Weight;	2020
Stereological Study of Changes of GABA-Immunoreactive Neurons in Spinal Dorsal Horn of SNI Rats. BioMed research international, 2021, Volume: 2021 Topics: Animals; Body Weight; GABAergic Neurons; gamma-Aminobutyric Acid; Immune System; Male; Neuralgia; Ne	2021
Gamma-Aminobutyric Acid Increases the Production of Short-Chain Fatty Acids and Decreases pH Values in Mouse Colon. Molecules (Basel, Switzerland), 2017, Apr-20, Volume: 22, Issue:4 Topics: Animals; Body Weight; Cecum; Colon; Fatty Acids, Volatile; Female; gamma-Aminobutyric Acid; Hydrogen	2017
Protective effects of GABA against metabolic and reproductive disturbances in letrozole induced polycystic ovarian syndrome in rats. Journal of ovarian research, 2017, Sep-15, Volume: 10, Issue:1 Topics: Androgen Antagonists; Animals; Blood Glucose; Body Weight; Catalase; Estradiol; Female; gamma-Aminob	2017
Recombinant tissue plasminogen activator induces long-term anxiety-like behaviors via the ERK1/2-GAD1-GABA cascade in the hippocampus of a rat model. Neuropharmacology, 2018, Volume: 128 Topics: Animals; Anxiety; bcl-2-Associated X Protein; Body Weight; Disease Models, Animal; Exploratory Behav	2018
Disease-modifying effects of ganglioside GM1 in Huntington's disease models. EMBO molecular medicine, 2017, Volume: 9, Issue:11 Topics: Animals; Behavior, Animal; Body Weight; Brain; Calcium-Binding Proteins; Disease Models, Animal; Dop	2017
Antihypertensive Effect of γ-Aminobutyric Acid-Enriched Brown Rice on Spontaneously Hypertensive Rats. Journal of nutritional science and vitaminology, 2018, Volume: 64, Issue:1 Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Deoxygua	2018
Novel metabolic disturbances in marginal vitamin B The Journal of nutritional biochemistry, 2019, Volume: 65 Topics: Animals; Body Weight; Carboxy-Lyases; Eating; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hear	2019
Palmatine plays a role in sedation and hypnosis by increasing 5-hydroxytryptamine. Cellular and molecular biology (Noisy-le-Grand, France), 2019, Apr-30, Volume: 65, Issue:4 Topics: Animals; Berberine Alkaloids; Body Weight; Brain; Cell Proliferation; Dose-Response Relationship, Dr	2019
Impaired Bidirectional Synaptic Plasticity in Juvenile Offspring Following Prenatal Ethanol Exposure. Alcoholism, clinical and experimental research, 2019, Volume: 43, Issue:10 Topics: Animals; Bicuculline; Body Weight; Dentate Gyrus; Female; Fetal Alcohol Spectrum Disorders; GABA Ant	2019
Dose-dependent influence of short-term intermittent ethanol intoxication on cerebral neurochemical changes in rats detected by ex vivo proton nuclear magnetic resonance spectroscopy. Neuroscience, 2014, Mar-14, Volume: 262 Topics: Alanine; Alcoholic Intoxication; Animals; Aspartic Acid; Body Weight; Central Nervous System Depress	2014
Subchronic toxicity evaluation of γ-aminobutyric acid (GABA) in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2014, Volume: 68 Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; gamma-	2014
Glutamate and GABA imbalance promotes neuronal apoptosis in hippocampus after stress. Medical science monitor : international medical journal of experimental and clinical research, 2014, Mar-27, Volume: 20 Topics: Animals; Anxiety; Apoptosis; Behavior, Animal; Body Weight; Dexamethasone; Emotions; Freezing Reacti	2014
Long-term behavioral programming induced by peripuberty stress in rats is accompanied by GABAergic-related alterations in the Amygdala. PloS one, 2014, Volume: 9, Issue:4 Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Body Weight; Exploratory Behavior; gamma-Aminobutyric	2014
Anti-allodynic and neuroprotective effects of koumine, a Benth alkaloid, in a rat model of diabetic neuropathy. Biological & pharmaceutical bulletin, 2014, Volume: 37, Issue:5 Topics: Amines; Animals; Blood Glucose; Body Weight; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Experim	2014
Insulin action on GABA neurons is a critical regulator of energy balance but not fertility in mice. Endocrinology, 2014, Volume: 155, Issue:11 Topics: Animals; Body Weight; Energy Metabolism; Female; Fertility; GABAergic Neurons; gamma-Aminobutyric Ac	2014
Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. Clinical pharmacokinetics, 2014, Volume: 53, Issue:11 Topics: Adult; Body Weight; Child; Child, Preschool; Enzyme Inhibitors; Epilepsy; Female; gamma-Aminobutyric	2014
Second generation anti-epileptic drugs adversely affect reproductive functions in young non-epileptic female rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2014, Volume: 24, Issue:10 Topics: Amines; Animals; Anticonvulsants; Astrocytes; Blotting, Western; Body Weight; Cyclohexanecarboxylic	2014
Effect of GABA on oxidative stress in the skeletal muscles and plasma free amino acids in mice fed high-fat diet. Journal of animal physiology and animal nutrition, 2015, Volume: 99, Issue:3 Topics: Amino Acids; Animals; Body Weight; Dietary Fats; Drinking; Eating; gamma-Aminobutyric Acid; Male; Mi	2015
Defense of Elevated Body Weight Setpoint in Diet-Induced Obese Rats on Low Energy Diet Is Mediated by Loss of Melanocortin Sensitivity in the Paraventricular Hypothalamic Nucleus. PloS one, 2015, Volume: 10, Issue:10 Topics: alpha-MSH; Animals; Arcuate Nucleus of Hypothalamus; Body Weight; Caloric Restriction; Diet; Dietary	2015
Extraction, purification and anti-fatigue activity of γ-aminobutyric acid from mulberry (Morus alba L.) leaves. Scientific reports, 2016, Jan-08, Volume: 6 Topics: Animals; Blood Urea Nitrogen; Body Weight; Fatigue; gamma-Aminobutyric Acid; Glycogen; Lactic Acid;	2016
Dietary Restriction Affects Neuronal Response Property and GABA Synthesis in the Primary Visual Cortex. PloS one, 2016, Volume: 11, Issue:2 Topics: Animal Feed; Animals; Blotting, Western; Body Weight; Brain; Brain Mapping; Caloric Restriction; Cat	2016
A high-fat diet decreases GABA concentration in the frontal cortex and hippocampus of rats. Biological research, 2016, Feb-29, Volume: 49 Topics: Animals; Blood Glucose; Body Weight; Diet, High-Fat; Feeding Behavior; Frontal Lobe; gamma-Aminobuty	2016
Essential fatty acid-rich diets protect against striatal oxidative damage induced by quinolinic acid in rats. Nutritional neuroscience, 2017, Volume: 20, Issue:7 Topics: Animals; Body Weight; Cholesterol; Corpus Striatum; Disease Models, Animal; Fatty Acids, Essential;	2017
Ketogenic diet prevents neuronal firing increase within the substantia nigra during pentylenetetrazole-induced seizure in rats. Brain research bulletin, 2016, Volume: 125 Topics: 3-Hydroxybutyric Acid; Action Potentials; Animals; Blood Glucose; Body Weight; Convulsants; Diet, Ke	2016
Hypothalamic arcuate nucleus tyrosine hydroxylase neurons play orexigenic role in energy homeostasis. Nature neuroscience, 2016, Volume: 19, Issue:10 Topics: Agouti-Related Protein; Animals; Arcuate Nucleus of Hypothalamus; Body Weight; Dopamine; Eating; Ene	2016
Ameliorative effect of synthetic γ-aminobutyric acid (GABA) on performance traits, antioxidant status and immune response in broiler exposed to cyclic heat stress. Environmental science and pollution research international, 2016, Volume: 23, Issue:23 Topics: Animal Feed; Animals; Antioxidants; Body Weight; Chickens; Dietary Supplements; gamma-Aminobutyric A	2016
Amylin Acts in the Lateral Dorsal Tegmental Nucleus to Regulate Energy Balance Through Gamma-Aminobutyric Acid Signaling. Biological psychiatry, 2017, Dec-01, Volume: 82, Issue:11 Topics: Amylin Receptor Agonists; Animals; Body Weight; Calcitonin; Conditioning, Operant; Eating; Food Pref	2017
Low dose rotenone treatment causes selective transcriptional activation of cell death related pathways in dopaminergic neurons in vivo. Neurobiology of disease, 2009, Volume: 33, Issue:2 Topics: Animals; Body Weight; Cell Death; Dopamine; Electron Transport Complex I; Exploratory Behavior; gamm	2009
Phosphatidylinositide dependent kinase deficiency increases anxiety and decreases GABA and serotonin abundance in the amygdala. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2008, Volume: 22, Issue:5-6 Topics: 3-Phosphoinositide-Dependent Protein Kinases; Amygdala; Animals; Anxiety; Behavior, Animal; Body Wei	2008
Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nature neuroscience, 2008, Volume: 11, Issue:9 Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Absorptiometry, Photon; Agouti-Re	2008
Effects of gamma-aminobutyric acid administration on health and growth rate of group-housed Japanese black calves fed using an automatic controlled milk feeder. The Journal of veterinary medical science, 2009, Volume: 71, Issue:5 Topics: Animals; Animals, Suckling; Aspartate Aminotransferases; Blood Glucose; Blood Proteins; Blood Urea N	2009
Isoflurane anesthesia interferes with the expression of cocaine-induced sensitization in female rats. Neuroscience letters, 2009, Oct-16, Volume: 464, Issue:1 Topics: Anesthetics, Inhalation; Animals; Body Weight; Cocaine; Estrous Cycle; Female; gamma-Aminobutyric Ac	2009
Intrastrain differences in seizure susceptibility, pharmacological response and basal neurochemistry of Wistar rats. Epilepsy research, 2009, Volume: 87, Issue:2-3 Topics: Analysis of Variance; Anesthetics, Dissociative; Animals; Biogenic Monoamines; Body Weight; Brain; B	2009
Rat medium-term multi-organ carcinogenesis bioassay of Agaricus blazei Murrill fruit-body extract. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2010, Volume: 48, Issue:1 Topics: Agaricus; Animals; Body Weight; Carcinogens; Drinking; Eating; Female; Fruiting Bodies, Fungal; gamm	2010
Effects of single and combined administration of fermented barley extract and gamma-aminobutyric acid on the development of atopic dermatitis in NC/Nga mice. Bioscience, biotechnology, and biochemistry, 2010, Volume: 74, Issue:1 Topics: Animals; Body Weight; Cytokines; Dermatitis, Atopic; Female; Fermentation; gamma-Aminobutyric Acid;	2010
Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence. Biological psychiatry, 2010, May-01, Volume: 67, Issue:9 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alcoholism; Amygdala; Animals; Body Weight; Central Nervous Sy	2010
Bimodal control of stimulated food intake by the endocannabinoid system. Nature neuroscience, 2010, Volume: 13, Issue:3 Topics: Animals; Body Weight; Brain; Corpus Striatum; Eating; Fasting; gamma-Aminobutyric Acid; Glutamic Aci	2010
Exercise changes regional vascular control by commissural NTS in spontaneously hypertensive rats. American journal of physiology. Regulatory, integrative and comparative physiology, 2010, Volume: 299, Issue:1 Topics: Animals; Blood Pressure; Blood Vessels; Body Weight; Chloralose; Energy Metabolism; gamma-Aminobutyr	2010
Lack of effect of intranigral transplants of a GABAergic cell line on absence seizures. Epilepsy & behavior : E&B, 2010, Volume: 18, Issue:4 Topics: Animals; Body Weight; Cell Line; Cell Transplantation; Disease Models, Animal; Epilepsy, Absence; ga	2010
Impaired hippocampal synaptic plasticity in C6 glioma-bearing rats. Journal of neuro-oncology, 2011, Volume: 103, Issue:3 Topics: Animals; Body Weight; Brain Neoplasms; Cell Line, Tumor; Chromatography, High Pressure Liquid; Disea	2011
Role of GABA receptors in fetal lung development in rats. PloS one, 2010, Nov-30, Volume: 5, Issue:11 Topics: Actins; Animals; Bicuculline; Body Weight; Cell Proliferation; Chlorides; Female; GABA Agents; GABA-	2010
Rats exposed to isoflurane in utero during early gestation are behaviorally abnormal as adults. Anesthesiology, 2011, Volume: 114, Issue:3 Topics: Anesthesia; Anesthetics, Inhalation; Animals; Anxiety; Behavior, Animal; Blood Pressure; Body Weight	2011
Pregabalin as a neuroprotector after spinal cord injury in rats: biochemical analysis and effect on glial cells. Journal of Korean medical science, 2011, Volume: 26, Issue:3 Topics: Animals; Apoptosis; Astrocytes; Blotting, Western; Body Weight; Caspase 3; Cell Proliferation; Fluor	2011
Adjunctive pregabalin for uncontrolled partial-onset seizures: findings from a prospective audit. Acta neurologica Scandinavica, 2011, Volume: 124, Issue:2 Topics: Adolescent; Adult; Aged; Anticonvulsants; Body Weight; Dose-Response Relationship, Drug; Drug Admini	2011
Chronic restraint stress impairs endocannabinoid mediated suppression of GABAergic signaling in the hippocampus of adult male rats. Brain research bulletin, 2011, Jul-15, Volume: 85, Issue:6 Topics: Animals; Body Weight; Cannabinoid Receptor Modulators; Endocannabinoids; gamma-Aminobutyric Acid; Hi	2011
Scopolamine impairs behavioural function and arginine metabolism in the rat dentate gyrus. Neuropharmacology, 2011, Volume: 61, Issue:8 Topics: Amino Acids; Animals; Arginine; Behavioral Symptoms; Body Weight; Brain Chemistry; Cholinergic Antag	2011
Possible GABAergic mechanism in the neuroprotective effect of gabapentin and lamotrigine against 3-nitropropionic acid induced neurotoxicity. European journal of pharmacology, 2012, Jan-15, Volume: 674, Issue:2-3 Topics: Amines; Animals; Body Weight; Brain; Catalase; Cyclohexanecarboxylic Acids; GABAergic Neurons; Gabap	2012
Effects of GABAB receptor agonists and antagonists on glycemia regulation in mice. European journal of pharmacology, 2012, Feb-29, Volume: 677, Issue:1-3 Topics: Animals; Baclofen; Basal Metabolism; Blood Glucose; Body Weight; Eating; GABA-B Receptor Agonists; G	2012
Role of GABA release from leptin receptor-expressing neurons in body weight regulation. Endocrinology, 2012, Volume: 153, Issue:5 Topics: Animals; Body Weight; Eating; Energy Metabolism; gamma-Aminobutyric Acid; Leptin; Mice; Mice, Transg	2012
Developmental exposure to manganese chloride induces sustained aberration of neurogenesis in the hippocampal dentate gyrus of mice. Toxicological sciences : an official journal of the Society of Toxicology, 2012, Volume: 127, Issue:2 Topics: Age Factors; Animals; Animals, Newborn; Apoptosis; Body Weight; Cell Adhesion Molecules, Neuronal; C	2012
Deciphering a neuronal circuit that mediates appetite. Nature, 2012, Mar-14, Volume: 483, Issue:7391 Topics: Agouti-Related Protein; Animals; Appetite; Body Weight; Feeding Behavior; Female; gamma-Aminobutyric	2012
GABA: a cotransmitter linking leptin to obesity prevention. Endocrinology, 2012, Volume: 153, Issue:5 Topics: Animals; Body Weight; gamma-Aminobutyric Acid; Neurons; Receptors, Leptin; Vesicular Inhibitory Amin	2012
Neurochemical characterization of body weight-regulating leptin receptor neurons in the nucleus of the solitary tract. Endocrinology, 2012, Volume: 153, Issue:10 Topics: Animals; Body Weight; Brain-Derived Neurotrophic Factor; Cholecystokinin; Energy Metabolism; gamma-A	2012
Endogenous content and release of [(3)H]-GABA and [(3)H]-glutamate in the spinal cord of chronically undernourished rat. Neurochemical research, 2013, Volume: 38, Issue:1 Topics: Animals; Body Mass Index; Body Weight; Calcium; Data Interpretation, Statistical; Female; gamma-Amin	2013
Neonatal leptin exposure specifies innervation of presympathetic hypothalamic neurons and improves the metabolic status of leptin-deficient mice. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Jan-09, Volume: 33, Issue:2 Topics: Adipose Tissue, Brown; Adipose Tissue, White; Animals; Animals, Newborn; Body Temperature Regulation	2013
Nutrigenomic effects of germinated brown rice and its bioactives on hepatic gluconeogenic genes in type 2 diabetic rats and HEPG2 cells. Molecular nutrition & food research, 2013, Volume: 57, Issue:3 Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; gamma-Aminobutyric Acid; Gene Expres	2013
Effect of γ-aminobutyric acid on growth performance and immune function in chicks under beak trimming stress. Animal science journal = Nihon chikusan Gakkaiho, 2013, Volume: 84, Issue:2 Topics: Adrenocorticotropic Hormone; Animal Husbandry; Animals; Beak; Body Weight; CD4 Lymphocyte Count; CD8	2013
Neonatal monosodium glutamate treatment modifies glutamic acid decarboxylase activity during rat brain postnatal development. Neurochemistry international, 2003, Volume: 42, Issue:4 Topics: Animals; Animals, Newborn; Body Weight; Brain; Cerebellum; Female; gamma-Aminobutyric Acid; Glutamat	2003
Chemical coding of GABA(B) receptor-immunoreactive neurones in hypothalamic regions regulating body weight. Journal of neuroendocrinology, 2003, Volume: 15, Issue:1 Topics: Animals; Antibodies; Arcuate Nucleus of Hypothalamus; Body Weight; Dorsomedial Hypothalamic Nucleus;	2003
Neurotransmitter levels in brains of chronically Jiawey Siwu-treated rats. The American journal of Chinese medicine, 2002, Volume: 30, Issue:4 Topics: Animals; Biogenic Monoamines; Body Weight; Brain Chemistry; Drugs, Chinese Herbal; Excitatory Amino	2002
Dietary protein restriction causes modification in aluminum-induced alteration in glutamate and GABA system of rat brain. BMC neuroscience, 2003, Feb-25, Volume: 4 Topics: 4-Aminobutyrate Transaminase; Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Body Weight;	2003
Aqueous extract of Monascus purpureus M9011 prevents and reverses fructose-induced hypertension in rats. Journal of agricultural and food chemistry, 2003, Jul-02, Volume: 51, Issue:14 Topics: Animals; Blood Glucose; Blood Pressure; Body Weight; Cholesterol; Cholesterol, HDL; Fructose; gamma-	2003
Protective effects of the antioxidant selenium on quinolinic acid-induced neurotoxicity in rats: in vitro and in vivo studies. Journal of neurochemistry, 2003, Volume: 86, Issue:2 Topics: Animals; Antioxidants; Behavior, Animal; Body Weight; Brain Chemistry; Corpus Striatum; gamma-Aminob	2003
Copper blocks quinolinic acid neurotoxicity in rats: contribution of antioxidant systems. Free radical biology & medicine, 2003, Aug-15, Volume: 35, Issue:4 Topics: Animals; Antioxidants; Blotting, Western; Body Weight; Ceruloplasmin; Copper; Copper Sulfate; Free R	2003
The reinforcing properties of alcohol are mediated by GABA(A1) receptors in the ventral pallidum. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003, Volume: 28, Issue:12 Topics: Alcoholism; Alcohols; Animals; Body Weight; Carbolines; Conditioning, Operant; Disease Models, Anima	2003
Perinatal iron deficiency alters the neurochemical profile of the developing rat hippocampus. The Journal of nutrition, 2003, Volume: 133, Issue:10 Topics: Aging; Animals; Aspartic Acid; Body Weight; Brain; Brain Chemistry; Creatine; Ethanolamines; Female;	2003
Stress impairs alpha(1A) adrenoceptor-mediated noradrenergic facilitation of GABAergic transmission in the basolateral amygdala. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2004, Volume: 29, Issue:1 Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adrenergic alpha-Antagonists; Adr	2004
Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice. The European journal of neuroscience, 2003, Volume: 18, Issue:10 Topics: 4-Butyrolactone; Adjuvants, Anesthesia; Animals; Anticonvulsants; Autoradiography; Baclofen; Behavio	2003
Cyclic GMP protein kinase activity is reduced in thyroxine-induced hypertrophic cardiac myocytes. Clinical and experimental pharmacology & physiology, 2003, Volume: 30, Issue:12 Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Body Weight; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dep	2003
Effect of valproic acid on levels of GABA and glutamic acid in pentylenetetrazole-damaged rat brain. Proceedings of the Western Pharmacology Society, 2003, Volume: 46 Topics: Animals; Anticonvulsants; Body Weight; Brain Chemistry; Convulsants; gamma-Aminobutyric Acid; Glutam	2003
Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science (New York, N.Y.), 2004, Apr-02, Volume: 304, Issue:5667 Topics: Animals; Arcuate Nucleus of Hypothalamus; Body Weight; Eating; Evoked Potentials; Excitatory Postsyn	2004
Critically timed ethanol exposure reduces GABAAR function on septal neurons developing in vivo but not in vitro. Brain research, 2004, May-15, Volume: 1008, Issue:1 Topics: Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Bicuculline; Body Weight; Cells, C	2004
Modulation of the gait deficit in arthritic rats by infusions of muscimol and bicuculline. Pain, 2004, Volume: 109, Issue:3 Topics: Animals; Arthralgia; Arthritis, Experimental; Body Weight; Disease Models, Animal; Dose-Response Rel	2004
Chronic placental insufficiency affects retinal development in the guinea pig. Investigative ophthalmology & visual science, 2004, Volume: 45, Issue:7 Topics: Amacrine Cells; Animals; Blotting, Western; Body Weight; Calbindin 2; Calbindins; Catecholamines; Ch	2004
Repeated administration of the GABAB receptor agonist CGP44532 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine-seeking in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:1 Topics: Animals; Body Weight; Conditioning, Operant; Cues; Food; GABA-B Receptor Agonists; gamma-Aminobutyri	2005
The effect of Vigabatrin, Lamotrigine and Gabapentin on the fertility, weights, sex hormones and biochemical profiles of male rats. Neuro endocrinology letters, 2004, Volume: 25, Issue:3 Topics: Amines; Analgesics; Animals; Antimanic Agents; Body Weight; Cyclohexanecarboxylic Acids; Female; Fer	2004
Chronic stress attenuates GABAergic inhibition and alters gene expression of parvocellular neurons in rat hypothalamus. The European journal of neuroscience, 2004, Volume: 20, Issue:6 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anim	2004
Suppressive effect of Saiko-ka-ryukotsu-borei-to, a herbal medicine, on excessive release of glutamate in the hippocampus. Brain research bulletin, 2004, Sep-30, Volume: 64, Issue:3 Topics: Animals; Body Weight; Disease Models, Animal; Drugs, Chinese Herbal; Excitatory Amino Acid Antagonis	2004
Effect of a gamma-aminobutyric acid-enriched dairy product on the blood pressure of spontaneously hypertensive and normotensive Wistar-Kyoto rats. The British journal of nutrition, 2004, Volume: 92, Issue:3 Topics: Administration, Oral; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Bl	2004
Protective effect of gamma-aminobutyric acid against glycerol-induced acute renal failure in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2004, Volume: 42, Issue:12 Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Body Weight; Creatinine; gamma-Aminobutyric Acid;	2004
Injectable dexamethasone administration enhances cortical GABAergic neuronal differentiation in a novel model of postnatal steroid therapy in mice. Pediatric research, 2005, Volume: 57, Issue:1 Topics: Animals; Animals, Newborn; Body Weight; Cell Death; Cell Differentiation; Cerebral Cortex; Dexametha	2005
Gestational and postnatal malnutrition affects sensitivity of young rats to picrotoxin and quinolinic acid and uptake of GABA by cortical and hippocampal slices. Brain research. Developmental brain research, 2005, Feb-08, Volume: 154, Issue:2 Topics: Analysis of Variance; Animals; Animals, Newborn; Body Weight; Caseins; Cerebral Cortex; Dose-Respons	2005
Behavioral and neurochemical repercussions of hippocampal network activity blockade during the neonatal period. Brain research. Developmental brain research, 2005, Mar-22, Volume: 155, Issue:1 Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Disease Models, Animal; Dopamine; Female;	2005
GABA transporter deficiency causes tremor, ataxia, nervousness, and increased GABA-induced tonic conductance in cerebellum. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Mar-23, Volume: 25, Issue:12 Topics: Animals; Anxiety; Ataxia; Behavior, Animal; Benzodiazepines; Body Temperature; Body Weight; Cerebell	2005
Maternal exposure to the antiepileptic drug vigabatrin affects postnatal development in the rat. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2005, Volume: 26, Issue:2 Topics: Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Birth Weight; Body Weight; Brain Chemi	2005
In vivo effect of chronic hypoxia on the neurochemical profile of the developing rat hippocampus. Brain research. Developmental brain research, 2005, May-12, Volume: 156, Issue:2 Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Body Weight; Brain Chem	2005
Role of the renal nerves in gamma-aminobutyric acid-induced antihypertensive effect in spontaneously hypertensive rats. European journal of pharmacology, 2005, Nov-07, Volume: 524, Issue:1-3 Topics: Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Creatinine; Denervation; Drinking; Ea	2005
Staying slim on a low-GABA diet. Nature medicine, 2006, Volume: 12, Issue:5 Topics: Animals; Appetite; Body Weight; Eating; gamma-Aminobutyric Acid; Humans; Hypothalamus; Mice; Recepto	2006
Dietary gamma-aminobutyric acid affects the brain protein synthesis rate in young rats. Amino acids, 2007, Volume: 32, Issue:2 Topics: Aging; Animal Feed; Animals; Body Weight; Brain; Brain Chemistry; Dietary Proteins; gamma-Aminobutyr	2007
Brain manganese accumulation is inversely related to gamma-amino butyric acid uptake in male and female rats. Toxicological sciences : an official journal of the Society of Toxicology, 2007, Volume: 95, Issue:1 Topics: Animals; Body Weight; Brain; Caudate Nucleus; Cerebellum; Female; gamma-Aminobutyric Acid; Globus Pa	2007
GABA, not glycine, mediates inhibition of latent respiratory motor pathways after spinal cord injury. Experimental neurology, 2007, Volume: 203, Issue:2 Topics: Animals; Bicuculline; Body Weight; Efferent Pathways; Female; GABA Antagonists; gamma-Aminobutyric A	2007
Iron deficient and manganese supplemented diets alter metals and transporters in the developing rat brain. Toxicological sciences : an official journal of the Society of Toxicology, 2007, Volume: 95, Issue:1 Topics: Amino Acids; Animals; Animals, Newborn; Body Weight; Brain; Cation Transport Proteins; Dietary Suppl	2007
GABA enhancement of maternal defense in mice: possible neural correlates. Pharmacology, biochemistry, and behavior, 2007, Volume: 86, Issue:1 Topics: Aggression; Animals; Body Weight; Chlordiazepoxide; Female; GABA Modulators; gamma-Aminobutyric Acid	2007
Effects of dietary administration of plant-derived anthocyanin-rich colors to spontaneously hypertensive rats. Journal of nutritional science and vitaminology, 2007, Volume: 53, Issue:1 Topics: Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Animals; Anthocyanins; Blood Pressur	2007
Ketogenic diet: electrophysiological effects on the normal human cortex. Epilepsia, 2007, Volume: 48, Issue:9 Topics: Adult; Blood Pressure; Body Temperature; Body Weight; Cerebral Cortex; Diet Therapy; Dietary Fats; E	2007
Pregabalin in central neuropathic pain associated with spinal cord injury: a placebo-controlled trial. Neurology, 2007, Jun-12, Volume: 68, Issue:24 Topics: Adverse Drug Reaction Reporting Systems; Analgesics; Anti-Anxiety Agents; Body Weight; Conflict of I	2007
Embryonic depletion of serotonin affects cortical development. The European journal of neuroscience, 2007, Volume: 26, Issue:2 Topics: Animals; Blotting, Western; Body Weight; Brain-Derived Neurotrophic Factor; Calbindin 2; Cell Count;	2007
Mixed effects modeling of weight change associated with placebo and pregabalin administration. Journal of pharmacokinetics and pharmacodynamics, 2007, Volume: 34, Issue:6 Topics: Body Weight; Clinical Trials as Topic; Female; gamma-Aminobutyric Acid; Humans; Male; Models, Biolog	2007
Dietary taurine supplementation ameliorates diabetic retinopathy via anti-excitotoxicity of glutamate in streptozotocin-induced Sprague-Dawley rats. Neurochemical research, 2008, Volume: 33, Issue:3 Topics: Amino Acid Transport System X-AG; Animals; Blood Glucose; Blotting, Western; Body Weight; Diabetes M	2008
Effects of prenatal exposure to the CB-1 receptor agonist WIN 55212-2 or CO on the GABAergic neuronal systems of rat cerebellar cortex. Neuroscience, 2007, Nov-09, Volume: 149, Issue:3 Topics: Animals; Atmosphere Exposure Chambers; Benzoxazines; Birth Weight; Body Weight; Carbon Monoxide; Cer	2007
Teratogenic effects of the anticonvulsant gabapentin in mice. Singapore medical journal, 2008, Volume: 49, Issue:1 Topics: Abnormalities, Drug-Induced; Amines; Animals; Anticonvulsants; Body Weight; Congenital Abnormalities	2008
Enhancement of social isolation-induced aggressive behavior of young mice by zinc deficiency. Life sciences, 2008, Apr-23, Volume: 82, Issue:17-18 Topics: Aggression; Animals; Behavior, Animal; Body Weight; Chromatography, High Pressure Liquid; Corticoste	2008
Brain neurotransmitter system and chronic lead intoxication. Pharmacological research communications, 1980, Volume: 12, Issue:5 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Body Weight; Brain; Cyclic GMP; Female; gamma-Aminobutyric	1980
Effect of acute and chronic phenobarbital treatment on GABA and other amino acids contents in seven regions of the rat brain. Journal of pharmacobio-dynamics, 1982, Volume: 5, Issue:2 Topics: Amino Acids; Animals; Body Weight; Brain; gamma-Aminobutyric Acid; Humans; Liver; Male; Neurotransmi	1982
Fenfluramine and brain transmitters in the obese Zucker rat. Neuropharmacology, 1984, Volume: 23, Issue:2A Topics: Animals; Body Weight; Brain Chemistry; Catecholamines; Dopamine; Feeding Behavior; Female; Fenfluram	1984
CSF neurochemistry of women with anorexia nervosa and normal women. The American journal of psychiatry, 1984, Volume: 141, Issue:11 Topics: Adolescent; Adult; Anorexia Nervosa; Body Weight; Calcium; Choline; Depressive Disorder; Female; gam	1984
Alleviation in the rat of a GABA-induced reduction in food intake and growth. Physiology & behavior, 1984, Volume: 33, Issue:1 Topics: 4-Aminobutyrate Transaminase; Animals; Body Temperature Regulation; Body Weight; Cold Temperature; D	1984
Effect of ascorbic acid deficiency on the in vivo synthesis of carnitine. Biochimica et biophysica acta, 1981, Jan-07, Volume: 672, Issue:1 Topics: Animals; Ascorbic Acid Deficiency; Body Weight; Carnitine; gamma-Aminobutyric Acid; Guinea Pigs; Kid	1981
Taurine mobilizing effects of beta alanine and other inhibitors of taurine transport. Life sciences, 1981, Jun-15, Volume: 28, Issue:24 Topics: Administration, Oral; Alanine; Animals; Appetite; beta-Alanine; Body Weight; gamma-Aminobutyric Acid	1981
Management of patients with bilateral amputations. British medical journal (Clinical research ed.), 1981, Sep-26, Volume: 283, Issue:6295 Topics: Body Weight; gamma-Aminobutyric Acid; Humans	1981
Evidence that a GABAergic mechanism influences the development of DOCA-salt hypertension in the rat. European journal of pharmacology, 1982, Sep-10, Volume: 83, Issue:1-2 Topics: Animals; Blood Pressure; Body Weight; Desoxycorticosterone; gamma-Aminobutyric Acid; Hypertension; M	1982
Time course relation between neurotoxic effects of kainic acid on behaviour and brain GABA-levels. Protection by gamma-vinyl GABA. Archives internationales de pharmacodynamie et de therapie, 1983, Volume: 261, Issue:1 Topics: Aminocaproates; Animals; Behavior, Animal; Body Weight; Brain Chemistry; gamma-Aminobutyric Acid; Ka	1983
Prolonged treatment with gamma-aminobutyric acid (GABA)-mimetic substances in prepubertal male rats. Archives of andrology, 1983, Volume: 10, Issue:3 Topics: 4-Butyrolactone; Alkynes; Aminocaproates; Animals; Body Weight; gamma-Aminobutyric Acid; Male; Organ	1983
An inability of gamma-acetylenic GABA to block eating evoked by hypothalamic stimulation. Behavioural brain research, 1980, Volume: 1, Issue:4 Topics: Alkynes; Aminocaproates; Animals; Body Weight; Brain Chemistry; Electric Stimulation; Feeding Behavi	1980
Dietary GABA decreases body weight of genetically obese mice. Life sciences, 1981, Dec-14, Volume: 29, Issue:24 Topics: 4-Aminobutyrate Transaminase; Animals; Body Weight; Diet; Eating; gamma-Aminobutyric Acid; Growth; M	1981
Developmental studies of the uptake of choline, GABA and dopamine by crude synaptosomal preparations after in vivo or in vitro lead treatment. Brain research, 1980, Apr-14, Volume: 187, Issue:2 Topics: Aging; Animals; Biological Transport; Body Weight; Brain; Cerebral Cortex; Choline; Corpus Striatum;	1980
Anorexic effects of ethanolamine-O-sulfate and muscimol in the rat: evidence that GABA inhibits ingestive behavior. Life sciences, 1980, Jun-09, Volume: 26, Issue:23 Topics: 4-Aminobutyrate Transaminase; Animals; Appetite Depressants; Body Weight; Brain Chemistry; Dextroamp	1980
Differential effect of fasting on hypothalamic expression of genes encoding neuropeptide Y, galanin, and glutamic acid decarboxylase. Brain research bulletin, 1993, Volume: 31, Issue:3-4 Topics: Animals; Arcuate Nucleus of Hypothalamus; Base Sequence; Blood Glucose; Body Weight; Fasting; Galani	1993
The effect of chronic treatment with the GABA transaminase inhibitors gamma-vinyl-GABA and ethanolamine-O-sulphate on the in vivo release of GABA from rat hippocampus. Journal of neurochemistry, 1995, Volume: 64, Issue:5 Topics: 4-Aminobutyrate Transaminase; Animals; Behavior, Animal; Body Weight; Calcium; Drinking; Ethanolamin	1995
Effect of green tea rich in gamma-aminobutyric acid on blood pressure of Dahl salt-sensitive rats. American journal of hypertension, 1995, Volume: 8, Issue:1 Topics: Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Disease Models, Animal; Female; gamma	1995
Suppression of haloperidol-induced oral dyskinesias in rats by vigabatrin. Pharmacology, biochemistry, and behavior, 1995, Volume: 50, Issue:2 Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Body Weight; Brain; Dyskinesia, Drug-Induced	1995
Hypothalamic GABAergic influences on treadmill exercise responses in rats. Brain research bulletin, 1994, Volume: 33, Issue:5 Topics: Animals; Behavior, Animal; Blood Pressure; Body Weight; GABA Antagonists; gamma-Aminobutyric Acid; H	1994
Regional alterations in the levels of brain biogenic amines, glutamate, GABA, and GAD activity due to chronic consumption of inorganic arsenic in developing and adult rats. Bulletin of environmental contamination and toxicology, 1993, Volume: 50, Issue:1 Topics: Age Factors; Animals; Arsenic; Biogenic Amines; Body Weight; Brain; Brain Chemistry; Female; gamma-A	1993
Testicular gamma-aminobutyric acid and circulating androgens in Syrian and Djungarian hamsters during sexual development. International journal of andrology, 1996, Volume: 19, Issue:3 Topics: Androgens; Animals; Body Weight; Cricetinae; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mesocrice	1996
Prenatal binge-like alcohol exposure alters neurochemical profiles in fetal rat brain. Pharmacology, biochemistry, and behavior, 1996, Volume: 55, Issue:4 Topics: Amniotic Fluid; Animals; Body Weight; Brain Chemistry; Central Nervous System Depressants; Chromatog	1996
Effect of glucose and 2-deoxyglucose on hypothalamic GABA release in lactating rats. Physiology & behavior, 1997, Volume: 61, Issue:2 Topics: Animals; Body Composition; Body Weight; Culture Techniques; Deoxyglucose; Eating; Energy Metabolism;	1997
Cerebrospinal fluid gamma-aminobutyric acid and glutamate values in dogs with epilepsy. American journal of veterinary research, 1997, Volume: 58, Issue:5 Topics: Aging; Animals; Body Weight; Chromatography, High Pressure Liquid; Dog Diseases; Dogs; Epilepsy; Fem	1997
Changes in body weight with chronic, high-dose gabapentin therapy. Therapeutic drug monitoring, 1997, Volume: 19, Issue:4 Topics: Acetates; Adolescent; Adult; Amines; Anticonvulsants; Body Weight; Cyclohexanecarboxylic Acids; Fema	1997
Effects of prenatal ethanol exposure on parvalbumin-expressing GABAergic neurons in the adult rat medial septum. Alcoholism, clinical and experimental research, 1997, Volume: 21, Issue:5 Topics: Animals; Body Weight; Cell Count; Cell Size; Ethanol; Female; Fetal Alcohol Spectrum Disorders; gamm	1997
Structural alterations of the hippocampal formation of adrenalectomized rats: an unbiased stereological study. Journal of neurocytology, 1997, Volume: 26, Issue:6 Topics: Adrenalectomy; Animals; Astrocytes; Body Weight; Cell Count; Dentate Gyrus; gamma-Aminobutyric Acid;	1997
Effect of chronic treatment with the GABA transaminase inhibitors gamma-vinyl GABA and ethanolamine O-sulphate on the in vitro GABA release from rat hippocampus. British journal of pharmacology, 1997, Volume: 122, Issue:3 Topics: 4-Aminobutyrate Transaminase; Amino Acids; Animals; Behavior, Animal; Body Weight; Brain Chemistry;	1997
Effect of injection of antisense oligodeoxynucleotides of GAD isozymes into rat ventromedial hypothalamus on food intake and locomotor activity. Brain research, 1998, Feb-16, Volume: 784, Issue:1-2 Topics: Animals; Body Weight; Chromatography, High Pressure Liquid; Eating; gamma-Aminobutyric Acid; Glutama	1998
Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Oct-01, Volume: 18, Issue:19 Topics: Aging; Animals; Antioxidants; Body Weight; Brain Chemistry; Calcium Radioisotopes; Cognition Disorde	1998
Corticofugal regulation of auditory sensitivity in the bat inferior colliculus. Journal of comparative physiology. A, Sensory, neural, and behavioral physiology, 1998, Volume: 183, Issue:6 Topics: Animals; Auditory Pathways; Auditory Threshold; Bicuculline; Body Weight; Chiroptera; Evoked Potenti	1998
Gabapentin prevents hyperalgesia during the formalin test in diabetic rats. Neuroscience letters, 1999, Mar-05, Volume: 262, Issue:2 Topics: Acetates; Amines; Analgesics; Animals; Blood Glucose; Body Weight; Cyclohexanecarboxylic Acids; Diab	1999
[1-(13)C]glucose metabolism in the tumoral and nontumoral cerebral tissue of a glioma-bearing rat. Journal of neurochemistry, 1999, Volume: 72, Issue:6 Topics: Alanine; Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Body Weight; Brain; Brain Neopla	1999
Effects of diabetes on non-adrenergic, non-cholinergic relaxation induced by GABA and electrical stimulation in the rat isolated duodenum. Clinical and experimental pharmacology & physiology, 1999, Volume: 26, Issue:9 Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Duodenum; Electric Stimulation	1999
Alterations in monoamines and GABA in the ventromedial and paraventricular nuclei of the hypothalamus following cold exposure: a reduction in noradrenaline induces hyperphagia. Brain research, 1999, Sep-18, Volume: 842, Issue:1 Topics: Animals; Biogenic Monoamines; Blood Glucose; Body Weight; Cold Temperature; Drinking; Eating; gamma-	1999
Influence of fetal alcohol exposure on the GABAergic regulation of growth hormone release in postnatal rats. Alcoholism, clinical and experimental research, 1999, Volume: 23, Issue:10 Topics: Age Factors; Animals; Animals, Newborn; Bicuculline; Body Weight; Central Nervous System Depressants	1999
Effect of experimental diabetes on GABA-mediated inhibition of neurally induced contractions in rat isolated trachea. Clinical and experimental pharmacology & physiology, 2000, Volume: 27, Issue:4 Topics: Acetylcholine; Animals; Baclofen; Bicuculline; Blood Glucose; Body Weight; Diabetes Mellitus, Experi	2000
Diazepam-like effects of a fish protein hydrolysate (Gabolysat PC60) on stress responsiveness of the rat pituitary-adrenal system and sympathoadrenal activity. Psychopharmacology, 2000, Volume: 149, Issue:1 Topics: Administration, Inhalation; Adrenocorticotropic Hormone; Animals; Anti-Anxiety Agents; Body Weight;	2000
Effect of oxidative stress on the uptake of GABA and glutamate in synaptosomes isolated from diabetic rat brain. Neuroendocrinology, 2000, Volume: 72, Issue:3 Topics: Animals; Ascorbic Acid; Blood Glucose; Body Weight; Brain; Diabetes Mellitus, Type 2; Disease Models	2000
Chronic lamotrigine treatment increases rat hippocampal GABA shunt activity and elevates cerebral taurine levels. Epilepsy research, 2001, Volume: 43, Issue:2 Topics: Amino Acids; Animals; Anticonvulsants; Body Weight; Brain; gamma-Aminobutyric Acid; Glutamic Acid; H	2001
Role of the central nervous system in the development of hypertension produced by chronic nitric oxide blockade in rats. Hypertension research : official journal of the Japanese Society of Hypertension, 2001, Volume: 24, Issue:1 Topics: Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Central Nervous System; Enzyme Inhibi	2001
Neurotoxicological outcomes of perinatal heptachlor exposure in the rat. Toxicological sciences : an official journal of the Society of Toxicology, 2001, Volume: 60, Issue:2 Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Brain; Brain Chemistry; Chlorides; Embryon	2001
Could reduced cerebrospinal fluid (csf) galanin contribute to restricted eating in anorexia nervosa? Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2001, Volume: 24, Issue:6 Topics: Adult; Anorexia Nervosa; Body Weight; Down-Regulation; Eating; Female; Galanin; gamma-Aminobutyric A	2001
Vincristine-induced allodynia in the rat. Pain, 2001, Volume: 93, Issue:1 Topics: Acetates; Amines; Analgesics; Animals; Antineoplastic Agents, Phytogenic; Body Weight; Cyclohexaneca	2001
Colocalization of GABA, enkephalin and neuropeptide Y in the tectum of the green frog Rana esculenta. Peptides, 2001, Volume: 22, Issue:7 Topics: Animals; Body Weight; Enkephalin, Methionine; Enkephalins; Female; gamma-Aminobutyric Acid; Male; Mi	2001
Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain. British journal of pharmacology, 2001, Volume: 133, Issue:6 Topics: Animals; Aspartic Acid; Body Weight; Brain; Cyclosporine; Drug Synergism; Everolimus; gamma-Aminobut	2001
Brain amino acid metabolism and ketosis. Journal of neuroscience research, 2001, Oct-15, Volume: 66, Issue:2 Topics: Amino Acids; Animals; Aspartic Acid; Blood-Brain Barrier; Body Weight; Brain; Coenzyme A; Dietary Fa	2001
Octylphenol and UV-B radiation alter larval development and hypothalamic gene expression in the leopard frog (Rana pipiens). Environmental health perspectives, 2002, Volume: 110, Issue:3 Topics: Animals; Body Weight; Carboxy-Lyases; DNA, Complementary; Estrogens, Non-Steroidal; Female; gamma-Am	2002
Cerebral GABA release and GAD activity in protein- and tryptophan-restricted rats during development. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2002, Volume: 20, Issue:1 Topics: Adaptation, Physiological; Animals; Animals, Newborn; Body Weight; Cerebral Cortex; Down-Regulation;	2002
Inhibitory action of halothane on rat masculine sexual behavior and sperm motility. Pharmacology, biochemistry, and behavior, 2002, Volume: 72, Issue:4 Topics: Administration, Inhalation; Anesthetics, Inhalation; Animals; Body Weight; Ejaculation; Female; gamm	2002
Therapeutic intervention in mice deficient for succinate semialdehyde dehydrogenase (gamma-hydroxybutyric aciduria). The Journal of pharmacology and experimental therapeutics, 2002, Volume: 302, Issue:1 Topics: Aldehyde Oxidoreductases; Animals; Benzocycloheptenes; Body Weight; gamma-Aminobutyric Acid; Genotyp	2002
Acute and chronic haloperidol treatment: comparison of effects on nigral dopaminergic cell activity. Life sciences, 1978, Oct-23, Volume: 23, Issue:16 Topics: Animals; Apomorphine; Body Weight; Dopamine; gamma-Aminobutyric Acid; Glutamates; Haloperidol; Kaini	1978
Elevation of brain histamine content in protein-deficient rats. Journal of neurochemistry, 1975, Volume: 24, Issue:5 Topics: Animals; Arginine; Body Weight; Brain Chemistry; Carnosine; gamma-Aminobutyric Acid; Histamine; Hist	1975
Effects of salt and water loading on carbohydrate and energy metabolism and levels of selected amino acids in the brains of young mice. Journal of neurochemistry, 1975, Volume: 24, Issue:5 Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Blood Glucose; Body Weight; Brain; Carbohydrate Metabo	1975
Effects of increasing brain GABA on the meal patterns of genetically obese vs. lean Zucker rats. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1992, Volume: 16, Issue:6 Topics: Animals; Body Weight; Brain Chemistry; Dose-Response Relationship, Drug; Eating; Ethanolamines; Fema	1992
Cis-dichlorodiammineplatinum alters GABAergic structures in the immature rat cerebellum. Neuroscience, 1992, Volume: 50, Issue:4 Topics: Animals; Body Weight; Cerebellum; Cisplatin; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Mitos	1992
Effects of alcohol dependence on shock-induced fighting: action of muscimol and homotaurine. Pharmacology, biochemistry, and behavior, 1992, Volume: 41, Issue:1 Topics: Aggression; Alcoholism; Animals; Body Weight; Electroshock; Ethanol; gamma-Aminobutyric Acid; Male;	1992
Effects of gamma-vinyl GABA (vigabatrin) on blood pressure and body weight of hypertensive and normotensive rats. Naunyn-Schmiedeberg's archives of pharmacology, 1992, Volume: 345, Issue:2 Topics: 4-Aminobutyrate Transaminase; Aminocaproates; Animals; Blood Pressure; Body Weight; Brain; gamma-Ami	1992
Comparative behavioral and neurochemical studies with striatal kainic acid- or quinolinic acid-lesioned rats. Pharmacology, biochemistry, and behavior, 1991, Volume: 39, Issue:2 Topics: Animals; Anxiety; Avoidance Learning; Behavior, Animal; Body Weight; Brain Chemistry; Corpus Striatu	1991
Regional alterations of brain biogenic amines and GABA/glutamate levels in rats following chronic lead exposure during neonatal development. Archives of toxicology, 1990, Volume: 64, Issue:4 Topics: Animals; Biogenic Amines; Body Weight; Brain; Dopamine; Dose-Response Relationship, Drug; Female; ga	1990
Behavioral effects of an intrauterine or neonatal diabetic environment in the rat. Biology of the neonate, 1991, Volume: 59, Issue:4 Topics: Animals; Animals, Newborn; Behavior, Animal; Blood Glucose; Body Weight; Brain Chemistry; Diabetes M	1991
Effects of chronic treatment with trihexyphenidyl and carbamazepine alone or in combination with haloperidol on substance P content in rat brain: a possible implication of substance P in affective disorders. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 245, Issue:3 Topics: Animals; Body Weight; Brain Chemistry; Carbamazepine; Dopamine; Dose-Response Relationship, Drug; ga	1988
Methylmercury-induced movement and postural disorders in developing rat: high-affinity uptake of choline, glutamate, and gamma-aminobutyric acid in the cerebral cortex and caudate-putamen. Journal of neurochemistry, 1989, Volume: 53, Issue:4 Topics: Animals; Biological Transport; Body Weight; Brain; Caudate Nucleus; Cerebral Cortex; Choline; gamma-	1989
Effect of furazolidone and nitrofurazone on brain gamma-amino butyric acid and glutamate concentrations in chickens. Clinical and experimental pharmacology & physiology, 1989, Volume: 16, Issue:5 Topics: Animals; Body Weight; Brain Chemistry; Chickens; Dose-Response Relationship, Drug; Furazolidone; gam	1989
Maternal undernutrition during lactation: effect on amino acids in brain regions of offspring. Journal of neurochemistry, 1985, Volume: 45, Issue:6 Topics: Amino Acids; Animals; Aspartic Acid; Body Weight; Brain Chemistry; Corpus Striatum; Female; gamma-Am	1985
Effect of early iron deficiency in rat on the gamma-aminobutyric acid shunt in brain. Journal of neurochemistry, 1986, Volume: 46, Issue:6 Topics: 4-Aminobutyrate Transaminase; Animals; Body Weight; Brain; Brain Chemistry; Erythrocyte Indices; Fem	1986
Chronic effects of perchloroethylene and trichloroethylene on the gerbil brain amino acids and glutathione. Neurotoxicology, 1986,Spring, Volume: 7, Issue:1 Topics: Amino Acids; Animals; Body Weight; Brain Chemistry; Female; gamma-Aminobutyric Acid; Gerbillinae; Gl	1986
Evidence that a GABAergic mechanism influences the development of obesity in obese Zucker rats. Pharmacological research communications, 1988, Volume: 20, Issue:12 Topics: Animals; beta-Endorphin; Body Weight; gamma-Aminobutyric Acid; Insulin; Obesity; Rats; Rats, Zucker;	1988
A nonglucocorticoid steroid analog of methylprednisolone duplicates its high-dose pharmacology in models of central nervous system trauma and neuronal membrane damage. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:1 Topics: Adrenocorticotropic Hormone; Animals; Body Weight; Brain; Brain Injuries; Cells, Cultured; gamma-Ami	1987
Gamma-aminobutyric acid and dysregulation of TSH secretion in uremic male rats. Nephron, 1987, Volume: 46, Issue:3 Topics: Animals; Bicuculline; Body Weight; gamma-Aminobutyric Acid; Male; Nephrectomy; Radioimmunoassay; Rat	1987
Effect of pre- and postnatal alcohol consumption on GABA levels of various brain regions in the rat offspring. Alcohol and alcoholism (Oxford, Oxfordshire), 1988, Volume: 23, Issue:1 Topics: Animals; Body Weight; Brain; Brain Chemistry; Disease Models, Animal; Ethanol; Female; Fetal Alcohol	1988
Effectiveness of physostigmine as a pretreatment drug for protection of rats from organophosphate poisoning. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1986, Volume: 6, Issue:3 Topics: Acetylcholinesterase; Action Potentials; Animals; Atropine; Body Weight; Brain; Brain Chemistry; Cho	1986
Alterations in cerebral glutamic acid decarboxylase and 3H-flunitrazepam binding during continuous treatment of rats for up to 1 year with haloperidol, sulpiride or clozapine. Journal of neural transmission, 1987, Volume: 68, Issue:1-2 Topics: Animals; Body Weight; Brain; Clozapine; Flunitrazepam; gamma-Aminobutyric Acid; Glutamate Decarboxyl	1987
Development of the gamma-aminobutyric acid neurotransmitter system in the rat cerebral cortex during repeated administration of the GABA-transaminase inhibitor ethanolamine O-sulphate. Journal of neurochemistry, 1986, Volume: 46, Issue:1 Topics: 4-Aminobutyrate Transaminase; Animals; Binding Sites; Body Weight; Cerebral Cortex; Dose-Response Re	1986
Effect of hyperphenylalaninemia on amino acid metabolism and compartmentation in neonatal rat brain. Brain research, 1974, Mar-08, Volume: 67, Issue:3 Topics: Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Body Weight; Brain; gamma-Aminobutyric Acid;	1974

gamma-aminobutyric acid and Body Weight