gamma-aminobutyric acid has been researched along with Bewilderment in 7 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gabapentin is an effective treatment for chronic neuropathic pain but may cause dizziness, drowsiness, and confusion in some older adults." | 5.27 | Gabapentin dose and the 30-day risk of altered mental status in older adults: A retrospective population-based study. ( Burneo, J; Dev, VK; Dixon, SN; Fleet, JL; Garg, AX; Kuwornu, PJ; Montero-Odasso, M, 2018) |
| "Gabapentin is an effective treatment for chronic neuropathic pain but may cause dizziness, drowsiness, and confusion in some older adults." | 2.87 | Gabapentin dose and the 30-day risk of altered mental status in older adults: A retrospective population-based study. ( Burneo, J; Dev, VK; Dixon, SN; Fleet, JL; Garg, AX; Kuwornu, PJ; Montero-Odasso, M, 2018) |
| " The goal of this study was to assess the association between gabapentin dosing and adverse outcomes by obtaining estimates of the 30-day risk of hospitalization with altered mental status and mortality in older adults (mean age 76 years) in Ontario, Canada initiated on high dose (>600 mg/day; n = 34,159) compared to low dose (≤600 mg/day; n = 76,025) oral gabapentin in routine outpatient care." | 2.87 | Gabapentin dose and the 30-day risk of altered mental status in older adults: A retrospective population-based study. ( Burneo, J; Dev, VK; Dixon, SN; Fleet, JL; Garg, AX; Kuwornu, PJ; Montero-Odasso, M, 2018) |
| "Postoperative pain was assessed by a telephone interview 1 and 3 months after operation." | 2.76 | Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial. ( Hammarén, E; Kontinen, VK; Pesonen, A; Raivio, P; Rosenberg, PH; Suojaranta-Ylinen, R; Tarkkila, P, 2011) |
| "Postoperative confusion was measured with the Confusion Assessment Method for the intensive care unit (CAM-ICU)." | 2.76 | Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial. ( Hammarén, E; Kontinen, VK; Pesonen, A; Raivio, P; Rosenberg, PH; Suojaranta-Ylinen, R; Tarkkila, P, 2011) |
| " Reported adverse effects were also analysed." | 2.47 | Efficacy and safety of perioperative pregabalin for post-operative pain: a meta-analysis of randomized-controlled trials. ( Cateloy, F; Engelman, E, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fleet, JL | 1 |
| Dixon, SN | 1 |
| Kuwornu, PJ | 1 |
| Dev, VK | 1 |
| Montero-Odasso, M | 1 |
| Burneo, J | 1 |
| Garg, AX | 1 |
| Sankary, S | 1 |
| Canino, P | 1 |
| Jackson, J | 1 |
| Mansfield, AS | 1 |
| Qian, Q | 1 |
| Blum, A | 1 |
| Simsolo, C | 1 |
| Tatour, I | 1 |
| Pesonen, A | 1 |
| Suojaranta-Ylinen, R | 1 |
| Hammarén, E | 1 |
| Kontinen, VK | 1 |
| Raivio, P | 1 |
| Tarkkila, P | 1 |
| Rosenberg, PH | 1 |
| Engelman, E | 1 |
| Cateloy, F | 1 |
| Stahl, SM | 1 |
| Thornton, JE | 1 |
| Simpson, ML | 1 |
| Berger, PA | 1 |
| Napoliello, MJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cognitive Changes Associated With Initiation of Gabapentin Treatment in Adults With Chronic Pain[NCT04106011] | 3 participants (Actual) | Observational | 2020-01-10 | Terminated (stopped due to PI request - low enrollment) | |||
| Perioperative Multimodal General Anesthesia Focusing on Specific CNS Targets in Patients Undergoing Cardiac Surgeries[NCT04016740] | Early Phase 1 | 22 participants (Actual) | Interventional | 2019-08-20 | Completed | ||
| Peri-Operative Pregabalin for Reducing opIoid Consumption AfTer Cardiac surgEry: A Randomized Trial[NCT04517110] | Phase 3 | 17 participants (Actual) | Interventional | 2021-04-09 | Terminated (stopped due to The COVID-19 pandemic has reduced recruitment such that the study is no longer feasible) | ||
| Comparison of Periosteal and Subcutaneous Infusions of Articaine and Bupivacaine in Treatment of Acute Pain After Sternotomy[NCT01536717] | Phase 4 | 36 participants (Actual) | Interventional | 2012-03-31 | Suspended | ||
| Effects of Pre-operative Oral Pregabalin on Post Operative Morphine Consumption After Abdominal Hysterectomy With/Without Salpingo-oophorectomy Under Spinal Anesthesia With Intrathecal Morphine[NCT02285010] | Phase 4 | 125 participants (Actual) | Interventional | 2014-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Time to first analgesia is recorded from IV PCA. (NCT02285010)
Timeframe: 24 hours
| Intervention | hour (Median) |
|---|---|
| Placebo | 4.6 |
| Pregabalin | 7.7 |
"Pain score is evaluated by nurses using Numerical Rating Scale (NRS)~Minimum score 0 (no pain), Maximum score 10 (worst imaginable pain), lower scores mean a better outcome" (NCT02285010)
Timeframe: 24 hours
| Intervention | score on a scale (Median) | |
|---|---|---|
| At rest | At movement | |
| Placebo | 2 | 4 |
| Pregabalin | 2 | 4 |
Cumulative morphine consumption in the first 24 hours is recorded from IV PCA (NCT02285010)
Timeframe: 6, 12, and 24 hours after operation
| Intervention | mg (Median) | ||
|---|---|---|---|
| Morphine consumption 6 hr | Morphine consumption 12 hr | Morphine consumption 24 hr | |
| Placebo | 1 | 1 | 4 |
| Pregabalin | 0 | 1 | 5 |
Measure sedation score by evaluate and observe; measure pruritus, PONV, dizziness, visual disturbance using questionnaire (NCT02285010)
Timeframe: 24 hours
| Intervention | Participants (Count of Participants) | |||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pruritus72177998 | Pruritus72177999 | Nausea72177998 | Nausea72177999 | Vomiting72177998 | Vomiting72177999 | Dizziness72177998 | Dizziness72177999 | Visual disturbance72177998 | Visual disturbance72177999 | |||||||||||||||||||||||||||||||
| No | Mild | Moderate | Severe | |||||||||||||||||||||||||||||||||||||
| Pregabalin | 17 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 35 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 31 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 15 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 10 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 1 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 3 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 18 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 23 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 24 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 21 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 16 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 31 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 38 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 10 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 9 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 12 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 8 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 5 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 6 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 14 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 39 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 9 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 7 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 1 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 51 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 45 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 7 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 16 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 0 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 0 | |||||||||||||||||||||||||||||||||||||||
1 review available for gamma-aminobutyric acid and Bewilderment
| Article | Year |
|---|---|
Efficacy and safety of perioperative pregabalin for post-operative pain: a meta-analysis of randomized-controlled trials.
Topics: Analgesics; Analgesics, Opioid; Confusion; Dizziness; Dose-Response Relationship, Drug; Endpoint Det | 2011 |
2 trials available for gamma-aminobutyric acid and Bewilderment
| Article | Year |
|---|---|
Gabapentin dose and the 30-day risk of altered mental status in older adults: A retrospective population-based study.
Topics: Aged; Aged, 80 and over; Amines; Confusion; Cyclohexanecarboxylic Acids; Disease-Free Survival; Dizz | 2018 |
Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cardiac Surgical Procedures; | 2011 |
Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cardiac Surgical Procedures; | 2011 |
Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cardiac Surgical Procedures; | 2011 |
Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cardiac Surgical Procedures; | 2011 |
Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cardiac Surgical Procedures; | 2011 |
Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cardiac Surgical Procedures; | 2011 |
Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cardiac Surgical Procedures; | 2011 |
Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cardiac Surgical Procedures; | 2011 |
Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cardiac Surgical Procedures; | 2011 |
4 other studies available for gamma-aminobutyric acid and Bewilderment
| Article | Year |
|---|---|
Phenibut overdose.
Topics: Adult; Confusion; Direct-to-Consumer Advertising; Drug Overdose; GABA Agonists; gamma-Aminobutyric A | 2017 |
71-year-old man with chronic kidney failure and sudden change of mental status.
Topics: Academic Medical Centers; Aged; Amines; Analgesics; Confusion; Cyclohexanecarboxylic Acids; Dose-Res | 2009 |
Hyponatremia and confusion caused by pregabalin.
Topics: Aged; Amputation, Surgical; Analgesics; Confusion; gamma-Aminobutyric Acid; Humans; Hyponatremia; Ma | 2009 |
Gamma-vinyl-GABA treatment of tardive dyskinesia and other movement disorders.
Topics: Adult; Aged; Aminocaproates; Confusion; Dyskinesia, Drug-Induced; Female; gamma-Aminobutyric Acid; H | 1985 |