Page last updated: 2024-10-16

gamma-aminobutyric acid and Benign Supratentorial Neoplasms

gamma-aminobutyric acid has been researched along with Benign Supratentorial Neoplasms in 3 studies

gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.

Research Excerpts

Excerpt	Relevance	Reference
"Gabapentin is an anticonvulsant drug that has analgesic properties for acute postoperative pain."	2.74	The analgesic effect of gabapentin as a prophylactic anticonvulsant drug on postcraniotomy pain: a prospective randomized study. ( Aykac, B; Bingol, CA; Karlikaya, G; Sayin, M; Türe, H; Türe, U, 2009)

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Kang, JS	1
Krakow, K	1
Roggendorf, J	1
Steinmetz, H	1
Hilker, R	1
Türe, H	1
Sayin, M	1
Karlikaya, G	1
Bingol, CA	1
Aykac, B	1
Türe, U	1
Gottschalk, A	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Gabapentin Regimens and Their Effects on Opioid Consumption[NCT03334903]			Phase 4	77 participants (Actual)	Interventional	2018-05-15	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

"VAS Score 1: How Much Pain do You Feel in Your Operative Site When Resting?"

Surgical site pain. Scale 0-10, with 0 best and 10 worst (NCT03334903)
Timeframe: 2-3 months after surgery (at 2nd postoperative appointment)

Intervention	score on 10-point scale (Mean)
Standard of Care	2.26
Postoperative Gabapentin Regimen	2.46

"VAS Score 2: How Much Pain do You Feel in Your Operative Site When Moving?"

Surgical site pain. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Intervention	score on a 10-point scale (Mean)
Standard of Care	3.84
Postoperative Gabapentin Regimen	3.54

"VAS Score 3: How Well Are You Sleeping?"

Sleep quality. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Intervention	score on a 10-point scale (Mean)
Standard of Care	5.73
Postoperative Gabapentin Regimen	6.38

"VAS Score 4: How Bad is Your Nausea?"

Nausea. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Intervention	score on a 10-point scale (Mean)
Standard of Care	0.36
Postoperative Gabapentin Regimen	0.17

"VAS Score 5: How Satisfied Are You With Your Pain Management?"

Satisfaction. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Intervention	score on a 10-point scale (Mean)
Standard of Care	7.83
Postoperative Gabapentin Regimen	8.48

Days Taking Opioids

Number of days until patients are finished consuming opioid medications after discharge. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Intervention	days (Mean)
Standard of Care	14.8
Postoperative Gabapentin Regimen	18.7

Opioid Consumption

Mean opioid consumption, measured in mg of morphine equivalents. (NCT03334903)
Timeframe: 2-3 months following surgery (total amount measured at second postoperative appointment; means assessed afterwards).

Intervention	morphine equivalents (Mean)
Standard of Care	287.0
Postoperative Gabapentin Regimen	281.1

Trials

1 trial available for gamma-aminobutyric acid and Benign Supratentorial Neoplasms

Article	Year
The analgesic effect of gabapentin as a prophylactic anticonvulsant drug on postcraniotomy pain: a prospective randomized study. Anesthesia and analgesia, 2009, Volume: 109, Issue:5 Topics: Administration, Oral; Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid;	2009

Other Studies

2 other studies available for gamma-aminobutyric acid and Benign Supratentorial Neoplasms

Article	Year
Botulinum toxin treatment of epilepsia partialis continua. Movement disorders : official journal of the Movement Disorder Society, 2009, Jan-15, Volume: 24, Issue:1 Topics: Anticonvulsants; Botulinum Toxins, Type A; Epilepsia Partialis Continua; Fructose; gamma-Aminobutyri	2009
Craniotomy pain: trying to do better. Anesthesia and analgesia, 2009, Volume: 109, Issue:5 Topics: Administration, Oral; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anticon	2009