gamma-aminobutyric acid has been researched along with Autosomal Dominant Juvenile Parkinson Disease in 72 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We review occupational Mn-induced parkinsonism and the dynamic modes of Mn transport in biological systems, as well as the detection and pharmacokinetic modeling of Mn trafficking." | 2.52 | Manganese-Induced Parkinsonism and Parkinson's Disease: Shared and Distinguishable Features. ( Aschner, M; Bowman, AB; Kwakye, GF; Mukhopadhyay, S; Paoliello, MM, 2015) |
| "It is hard to define what ratio of insomnia and daytime hypersomnia is caused by the antiparkinsonian treatment, by the somatic and mental-emotional symptoms of the neurodegenerative disease and by the neurodegenerative brain process itself." | 2.44 | [Sleep disorders in Parkinson syndromes]. ( Kovács, GG; Lalit, N; Péter, H; Szucs, A, 2007) |
| "Among 5,653,547 reports, 4925 parkinsonism reports were found with pregabalin and 4881 with gabapentin." | 1.56 | Parkinsonism associated with gabapentinoid drugs: A pharmacoepidemiologic study. ( Chebane, L; Lapeyre-Mestre, M; Montastruc, F; Montastruc, JL; Pacheco-Paez, T; Renoux, C; Rousseau, V, 2020) |
| "In a mouse model of early parkinsonism, GATs are downregulated, tonic GABAergic inhibition of DA release augmented, and nigrostriatal GABA co-release attenuated." | 1.56 | GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model. ( Bengoa-Vergniory, N; Brimblecombe, KR; Connor-Robson, N; Cragg, SJ; Doig, NM; Lopes, EF; Magill, PJ; Pasternack, N; Roberts, BM; Siddorn, RE; Threlfell, S; Wade-Martins, R, 2020) |
| "Recent data showed that rats induced to Parkinsonism by 6-hydroxydopamine (6-OHDA) administration in the substantia nigra pars compacta (SNpc) showed lower mean arterial pressure (MAP) and heart rate (HR), as reduction in sympathetic modulation." | 1.51 | Glutamate and GABA neurotransmission are increased in paraventricular nucleus of hypothalamus in rats induced to 6-OHDA parkinsonism: Involvement of nNOS. ( Ariza, D; Crestani, CC; Cruz Lucchetti, BF; de Jager, L; Martins, AB; Martins-Pinge, MC; Pinge-Filho, P; Rodrigues, AT; Turossi Amorim, ED; Uchoa, ET, 2019) |
| "The onset of motor deficits in parkinsonism is thought to result from dopamine (DA) loss-induced corticostriatal disruption and the development of excessive cortico-basal ganglia synchronization." | 1.46 | Frequency-Dependent Corticostriatal Disinhibition Resulting from Chronic Dopamine Depletion: Role of Local Striatal cGMP and GABA-AR Signaling. ( Flores-Barrera, E; Jayasinghe, VR; Tseng, KY; West, AR, 2017) |
| "Manganese treatment produced increased aspartate (P < 0." | 1.31 | Low cumulative manganese exposure affects striatal GABA but not dopamine. ( Gwiazda, RH; Lee, D; Sheridan, J; Smith, DR, 2002) |
| " A sub-chronic dosing regimen of low cumulative manganese exposure (4." | 1.31 | Low cumulative manganese exposure affects striatal GABA but not dopamine. ( Gwiazda, RH; Lee, D; Sheridan, J; Smith, DR, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 37 (51.39) | 29.6817 |
| 2010's | 28 (38.89) | 24.3611 |
| 2020's | 7 (9.72) | 2.80 |
| Authors | Studies |
|---|---|
| Guo, Y | 2 |
| Zhu, H | 1 |
| Wang, Y | 3 |
| Sun, T | 1 |
| Xu, J | 1 |
| Wang, T | 2 |
| Guan, W | 1 |
| Wang, C | 1 |
| Liu, C | 1 |
| Ma, C | 1 |
| Abe, Y | 1 |
| Yagishita, S | 1 |
| Sano, H | 1 |
| Sugiura, Y | 1 |
| Dantsuji, M | 1 |
| Suzuki, T | 1 |
| Mochizuki, A | 1 |
| Yoshimaru, D | 1 |
| Hata, J | 1 |
| Matsumoto, M | 1 |
| Taira, S | 1 |
| Takeuchi, H | 1 |
| Okano, H | 1 |
| Ohno, N | 1 |
| Suematsu, M | 1 |
| Inoue, T | 1 |
| Nambu, A | 1 |
| Watanabe, M | 1 |
| Tanaka, KF | 1 |
| Pacheco-Paez, T | 1 |
| Montastruc, F | 1 |
| Rousseau, V | 1 |
| Chebane, L | 1 |
| Lapeyre-Mestre, M | 1 |
| Renoux, C | 1 |
| Montastruc, JL | 1 |
| Kiessling, CY | 1 |
| Lanza, K | 1 |
| Feinberg, E | 1 |
| Bishop, C | 2 |
| Nishijima, H | 1 |
| Mori, F | 1 |
| Arai, A | 1 |
| Zhu, G | 1 |
| Wakabayashi, K | 1 |
| Okada, M | 1 |
| Ueno, S | 1 |
| Ichinohe, N | 1 |
| Suzuki, C | 1 |
| Kon, T | 1 |
| Tomiyama, M | 1 |
| Brugnoli, A | 1 |
| Pisanò, CA | 1 |
| Morari, M | 6 |
| Roberts, BM | 1 |
| Doig, NM | 1 |
| Brimblecombe, KR | 1 |
| Lopes, EF | 1 |
| Siddorn, RE | 1 |
| Threlfell, S | 1 |
| Connor-Robson, N | 1 |
| Bengoa-Vergniory, N | 1 |
| Pasternack, N | 1 |
| Wade-Martins, R | 1 |
| Magill, PJ | 1 |
| Cragg, SJ | 1 |
| Sun, YN | 1 |
| Yao, L | 2 |
| Li, LB | 1 |
| Du, CX | 1 |
| Liu, J | 2 |
| Turossi Amorim, ED | 1 |
| de Jager, L | 1 |
| Martins, AB | 1 |
| Rodrigues, AT | 1 |
| Cruz Lucchetti, BF | 1 |
| Ariza, D | 1 |
| Pinge-Filho, P | 1 |
| Crestani, CC | 1 |
| Uchoa, ET | 1 |
| Martins-Pinge, MC | 1 |
| Liu, Y | 2 |
| Zong, X | 1 |
| Huang, J | 1 |
| Guan, Y | 1 |
| Li, Y | 1 |
| Du, T | 1 |
| Liu, K | 1 |
| Kang, X | 1 |
| Dou, C | 1 |
| Sun, X | 1 |
| Wu, R | 1 |
| Wen, L | 1 |
| Zhang, Y | 1 |
| López-Huerta, VG | 1 |
| Carrillo-Reid, L | 1 |
| Galarraga, E | 1 |
| Tapia, D | 1 |
| Fiordelisio, T | 1 |
| Drucker-Colin, R | 1 |
| Bargas, J | 1 |
| Fu, A | 1 |
| Zhao, Z | 1 |
| Gao, F | 1 |
| Zhang, M | 1 |
| Smith, KM | 1 |
| Browne, SE | 1 |
| Jayaraman, S | 1 |
| Bleickardt, CJ | 1 |
| Hodge, LM | 1 |
| Lis, E | 1 |
| Rittle, SL | 1 |
| Innocent, N | 1 |
| Mullins, DE | 1 |
| Boykow, G | 1 |
| Reynolds, IJ | 1 |
| Hill, D | 1 |
| Parker, EM | 1 |
| Hodgson, RA | 1 |
| Cremer, JN | 1 |
| Amunts, K | 1 |
| Graw, J | 1 |
| Piel, M | 1 |
| Rösch, F | 1 |
| Zilles, K | 1 |
| Chu, HY | 1 |
| Atherton, JF | 1 |
| Wokosin, D | 1 |
| Surmeier, DJ | 1 |
| Bevan, MD | 1 |
| Mastro, KJ | 1 |
| Gittis, AH | 1 |
| Papa, SM | 1 |
| Wichmann, T | 1 |
| Kwakye, GF | 1 |
| Paoliello, MM | 1 |
| Mukhopadhyay, S | 1 |
| Bowman, AB | 1 |
| Aschner, M | 1 |
| Borgkvist, A | 1 |
| Avegno, EM | 1 |
| Wong, MY | 1 |
| Kheirbek, MA | 1 |
| Sonders, MS | 1 |
| Hen, R | 1 |
| Sulzer, D | 1 |
| Jayasinghe, VR | 1 |
| Flores-Barrera, E | 1 |
| West, AR | 1 |
| Tseng, KY | 1 |
| McCreary, AC | 1 |
| Varney, MA | 1 |
| Newman-Tancredi, A | 1 |
| Lindenbach, D | 1 |
| Conti, MM | 1 |
| Ostock, CY | 1 |
| George, JA | 1 |
| Goldenberg, AA | 1 |
| Melikhov-Sosin, M | 1 |
| Nuss, EE | 1 |
| Wei, W | 1 |
| Ding, S | 1 |
| Zhou, FM | 1 |
| Rangel-Barajas, C | 2 |
| Silva, I | 2 |
| García-Ramírez, M | 1 |
| Sánchez-Lemus, E | 1 |
| Floran, L | 1 |
| Aceves, J | 3 |
| Erlij, D | 3 |
| Florán, B | 3 |
| Barroso-Chinea, P | 1 |
| Rico, AJ | 1 |
| Pérez-Manso, M | 1 |
| Roda, E | 1 |
| López, IP | 1 |
| Luis-Ravelo, D | 1 |
| Lanciego, JL | 1 |
| Thompson, LH | 1 |
| Kirik, D | 2 |
| Björklund, A | 2 |
| Mukhida, K | 1 |
| Hong, M | 1 |
| Miles, GB | 1 |
| Phillips, T | 1 |
| Baghbaderani, BA | 1 |
| McLeod, M | 1 |
| Kobayashi, N | 1 |
| Sen, A | 1 |
| Behie, LA | 1 |
| Brownstone, RM | 1 |
| Mendez, I | 1 |
| Boulet, S | 1 |
| Mounayar, S | 1 |
| Poupard, A | 2 |
| Bertrand, A | 2 |
| Jan, C | 1 |
| Pessiglione, M | 1 |
| Hirsch, EC | 1 |
| Feuerstein, C | 2 |
| François, C | 1 |
| Féger, J | 1 |
| Savasta, M | 2 |
| Tremblay, L | 1 |
| Marti, M | 5 |
| Trapella, C | 2 |
| Mabrouk, OS | 3 |
| Volta, M | 1 |
| Freund, HJ | 1 |
| Kuhn, J | 1 |
| Lenartz, D | 1 |
| Mai, JK | 1 |
| Schnell, T | 1 |
| Klosterkoetter, J | 1 |
| Sturm, V | 1 |
| Nandhu, MS | 1 |
| Fabia, ET | 1 |
| Paulose, CS | 1 |
| Salvadori, S | 1 |
| Korkmaz, OT | 1 |
| Tunçel, N | 1 |
| Tunçel, M | 1 |
| Oncü, EM | 1 |
| Sahintürk, V | 1 |
| Celik, M | 1 |
| Zhang, QJ | 1 |
| Ali, U | 1 |
| Gui, ZH | 1 |
| Hui, YP | 1 |
| Chen, L | 1 |
| Lopéz-Santiago, LM | 1 |
| Venero, JL | 1 |
| Mauriño, R | 1 |
| Machado, A | 1 |
| Santiago, M | 1 |
| Hutter-Saunders, JA | 1 |
| Kosloski, LM | 1 |
| McMillan, JM | 1 |
| Yotam, N | 1 |
| Rinat, T | 1 |
| Mosley, RL | 1 |
| Gendelman, HE | 1 |
| McCarthy, MM | 1 |
| Moore-Kochlacs, C | 1 |
| Gu, X | 1 |
| Boyden, ES | 1 |
| Han, X | 1 |
| Kopell, N | 1 |
| Ferraro, L | 1 |
| O'Connor, WT | 1 |
| Beggiato, S | 1 |
| Tomasini, MC | 1 |
| Fuxe, K | 1 |
| Tanganelli, S | 1 |
| Antonelli, T | 1 |
| Samoudi, G | 1 |
| Nissbrandt, H | 1 |
| Dutia, MB | 1 |
| Bergquist, F | 1 |
| Coune, PG | 1 |
| Craveiro, M | 1 |
| Gaugler, MN | 1 |
| Mlynárik, V | 1 |
| Schneider, BL | 1 |
| Aebischer, P | 1 |
| Gruetter, R | 1 |
| Dehorter, N | 1 |
| Lozovaya, N | 1 |
| Mdzomba, BJ | 1 |
| Michel, FJ | 1 |
| Lopez, C | 1 |
| Tsintsadze, V | 1 |
| Tsintsadze, T | 1 |
| Klinkenberg, M | 1 |
| Gispert, S | 1 |
| Auburger, G | 1 |
| Hammond, C | 1 |
| McCormack, AL | 1 |
| Thiruchelvam, M | 1 |
| Manning-Bog, AB | 1 |
| Thiffault, C | 1 |
| Langston, JW | 1 |
| Cory-Slechta, DA | 1 |
| Di Monte, DA | 1 |
| Schroeder, JA | 1 |
| Schneider, JS | 1 |
| Gwiazda, RH | 1 |
| Lee, D | 1 |
| Sheridan, J | 1 |
| Smith, DR | 1 |
| Luo, J | 1 |
| Kaplitt, MG | 1 |
| Fitzsimons, HL | 1 |
| Zuzga, DS | 1 |
| Oshinsky, ML | 1 |
| During, MJ | 1 |
| Nandi, D | 1 |
| Aziz, TZ | 1 |
| Giladi, N | 1 |
| Winter, J | 1 |
| Stein, JF | 1 |
| Fox, SH | 1 |
| Henry, B | 1 |
| Hill, M | 1 |
| Crossman, A | 1 |
| Brotchie, J | 1 |
| Gerstein, LM | 1 |
| Dovedova, EL | 1 |
| Popova, NS | 1 |
| Alfinito, PD | 1 |
| Wang, SP | 1 |
| Manzino, L | 1 |
| Rijhsinghani, S | 1 |
| Zeevalk, GD | 1 |
| Sonsalla, PK | 1 |
| Kase, H | 4 |
| Aoyama, S | 1 |
| Ichimura, M | 1 |
| Ikeda, K | 1 |
| Ishii, A | 1 |
| Kanda, T | 1 |
| Koga, K | 1 |
| Koike, N | 1 |
| Kurokawa, M | 1 |
| Kuwana, Y | 1 |
| Mori, A | 1 |
| Nakamura, J | 1 |
| Nonaka, H | 1 |
| Ochi, M | 3 |
| Saki, M | 1 |
| Shimada, J | 1 |
| Shindou, T | 1 |
| Shiozaki, S | 3 |
| Suzuki, F | 1 |
| Takeda, M | 1 |
| Yanagawa, K | 1 |
| Richardson, PJ | 1 |
| Jenner, P | 1 |
| Bedard, P | 1 |
| Borrelli, E | 1 |
| Hauser, RA | 1 |
| Chase, TN | 1 |
| Bruet, N | 1 |
| Windels, F | 1 |
| Carcenac, C | 1 |
| Stephenson, DT | 1 |
| Li, Q | 1 |
| Simmons, C | 1 |
| Connell, MA | 1 |
| Meglasson, MD | 1 |
| Merchant, K | 1 |
| Emborg, ME | 1 |
| Mazloom, M | 1 |
| Smith, Y | 1 |
| Mallet, N | 1 |
| Ballion, B | 1 |
| Le Moine, C | 1 |
| Gonon, F | 1 |
| Suon, S | 1 |
| Yang, M | 1 |
| Iacovitti, L | 1 |
| Yamamoto, N | 1 |
| Pierce, RC | 1 |
| Soghomonian, JJ | 2 |
| Wang, H | 1 |
| Katz, J | 1 |
| Dagostino, P | 1 |
| Viaro, R | 1 |
| Yi, PL | 1 |
| Tsai, CH | 1 |
| Lu, MK | 1 |
| Liu, HJ | 1 |
| Chen, YC | 1 |
| Chang, FC | 1 |
| Szucs, A | 1 |
| Kovács, GG | 1 |
| Lalit, N | 1 |
| Péter, H | 1 |
| Struve, MF | 1 |
| McManus, BE | 1 |
| Wong, BA | 1 |
| Dorman, DC | 1 |
| Chassain, C | 1 |
| Bielicki, G | 1 |
| Durand, E | 1 |
| Lolignier, S | 1 |
| Essafi, F | 1 |
| Traoré, A | 1 |
| Durif, F | 1 |
| Carta, AR | 1 |
| Frau, L | 1 |
| Lucia, F | 1 |
| Pinna, A | 1 |
| Annalisa, P | 1 |
| Pontis, S | 1 |
| Silvia, P | 1 |
| Simola, N | 1 |
| Nicola, S | 1 |
| Schintu, N | 1 |
| Nicoletta, S | 1 |
| Morelli, M | 1 |
| Micaela, M | 1 |
| Winkler, C | 1 |
| Dunnett, SB | 1 |
| Galvan, A | 1 |
| Ni, Z | 1 |
| Gao, D | 1 |
| Bouali-Benazzouz, R | 1 |
| Benabid, AL | 1 |
| Benazzouz, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multi-targets, Single-lead GPi+NBM DBS in Parkinson's Disease With Mild Cognitive Impairment[NCT04571112] | 6 participants (Actual) | Interventional | 2017-12-04 | Completed | |||
| Simultaneous Deep Brain Stimulation of the Globus Pallidus Internus and the Nucleus Basalis of Meynert in Patients With Parkinson's Disease and Mild Cognitive Impairment[NCT05320523] | 10 participants (Anticipated) | Interventional | 2021-07-20 | Recruiting | |||
| Phase I Study of Subthalamic GAD Gene Transfer in Medically Refractory Parkinson's Disease Patients[NCT00195143] | Phase 1 | 12 participants | Interventional | 2003-08-31 | Completed | ||
| A Phase II, Randomized, Open-label, Double-blind, Two-center Study to Evaluate the Tolerability, Safety and Dose-finding of Oil Cannabis Preparation for Pain in Parkinson's Disease[NCT03639064] | Phase 2 | 15 participants (Anticipated) | Interventional | 2020-12-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for gamma-aminobutyric acid and Autosomal Dominant Juvenile Parkinson Disease
| Article | Year |
|---|---|
Manganese-Induced Parkinsonism and Parkinson's Disease: Shared and Distinguishable Features.
Topics: Brain; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Magnesium; Manganese Poisoning; Par | 2015 |
Progress in pursuit of therapeutic A2A antagonists: the adenosine A2A receptor selective antagonist KW6002: research and development toward a novel nondopaminergic therapy for Parkinson's disease.
Topics: Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Clinical Trials as Topic; Corpus S | 2003 |
[Sleep disorders in Parkinson syndromes].
Topics: Acetylcholine; Antidepressive Agents; Antiparkinson Agents; Diagnosis, Differential; Disorders of Ex | 2007 |
Transplantation in the rat model of Parkinson's disease: ectopic versus homotopic graft placement.
Topics: Animals; Brain Tissue Transplantation; Disability Evaluation; Disease Models, Animal; Dopamine; gamm | 2000 |
New aspects of physiological and pathophysiological functions of adenosine A2A receptor in basal ganglia.
Topics: Adenosine; Animals; Basal Ganglia; gamma-Aminobutyric Acid; Humans; Models, Neurological; Neurotrans | 2001 |
1 trial available for gamma-aminobutyric acid and Autosomal Dominant Juvenile Parkinson Disease
| Article | Year |
|---|---|
Cognitive functions in a patient with Parkinson-dementia syndrome undergoing deep brain stimulation.
Topics: Acetylcholine; Aged; Arousal; Attention; Basal Nucleus of Meynert; Cholinergic Fibers; Cognition; Co | 2009 |
Cognitive functions in a patient with Parkinson-dementia syndrome undergoing deep brain stimulation.
Topics: Acetylcholine; Aged; Arousal; Attention; Basal Nucleus of Meynert; Cholinergic Fibers; Cognition; Co | 2009 |
Cognitive functions in a patient with Parkinson-dementia syndrome undergoing deep brain stimulation.
Topics: Acetylcholine; Aged; Arousal; Attention; Basal Nucleus of Meynert; Cholinergic Fibers; Cognition; Co | 2009 |
Cognitive functions in a patient with Parkinson-dementia syndrome undergoing deep brain stimulation.
Topics: Acetylcholine; Aged; Arousal; Attention; Basal Nucleus of Meynert; Cholinergic Fibers; Cognition; Co | 2009 |
66 other studies available for gamma-aminobutyric acid and Autosomal Dominant Juvenile Parkinson Disease
| Article | Year |
|---|---|
Miniature-swine iPSC-derived GABA progenitor cells function in a rat Parkinson's disease model.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; GABAergic Neurons; gamma-Ami | 2023 |
Shared GABA transmission pathology in dopamine agonist- and antagonist-induced dyskinesia.
Topics: Animals; Antiparkinson Agents; Dopamine; Dopamine Agonists; Dyskinesia, Drug-Induced; gamma-Aminobut | 2023 |
Parkinsonism associated with gabapentinoid drugs: A pharmacoepidemiologic study.
Topics: Aged; Bayes Theorem; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Parkins | 2020 |
Dopamine receptor cooperativity synergistically drives dyskinesia, motor behavior, and striatal GABA neurotransmission in hemiparkinsonian rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Corpus Striatum; Dopamine Agoni | 2020 |
GABA storage and release in the medial globus pallidus in L-DOPA-induced dyskinesia priming.
Topics: Animals; Antiparkinson Agents; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Globus Pallidus; L | 2020 |
Striatal and nigral muscarinic type 1 and type 4 receptors modulate levodopa-induced dyskinesia and striato-nigral pathway activation in 6-hydroxydopamine hemilesioned rats.
Topics: Allosteric Regulation; Animals; Dopamine Agents; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; | 2020 |
GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model.
Topics: Animals; Astrocytes; Cell Membrane; Corpus Striatum; Disease Models, Animal; Dopamine; Down-Regulati | 2020 |
Activation and blockade of basolateral amygdala 5-HT
Topics: Animals; Anti-Anxiety Agents; Anxiety; Basolateral Nuclear Complex; Corpus Striatum; Dopamine; gamma | 2018 |
Glutamate and GABA neurotransmission are increased in paraventricular nucleus of hypothalamus in rats induced to 6-OHDA parkinsonism: Involvement of nNOS.
Topics: Animals; Blood Pressure; Cardiovascular System; gamma-Aminobutyric Acid; Glutamic Acid; Heart Rate; | 2019 |
Ginsenoside Rb1 regulates prefrontal cortical GABAergic transmission in MPTP-treated mice.
Topics: Animals; Cell Line; gamma-Aminobutyric Acid; Ginsenosides; Humans; Male; Mice; Mice, Inbred C57BL; P | 2019 |
The balance of striatal feedback transmission is disrupted in a model of parkinsonism.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adrenergic Agents; Anesthetics, Local; Anim | 2013 |
Cellular uptake mechanism and therapeutic utility of a novel peptide in targeted-delivery of proteins into neuronal cells.
Topics: Amino Acid Sequence; Animals; Brain; Cell Line; Drug Delivery Systems; Endocytosis; gamma-Aminobutyr | 2013 |
Effects of the selective adenosine A2A receptor antagonist, SCH 412348, on the parkinsonian phenotype of MitoPark mice.
Topics: Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Dose-Response Relationship, Drug; | 2014 |
Neurotransmitter receptor density changes in Pitx3ak mice--a model relevant to Parkinson's disease.
Topics: Acetylcholine; Adenosine; Animals; Brain; Dopamine; Epinephrine; gamma-Aminobutyric Acid; Homeodomai | 2015 |
Heterosynaptic regulation of external globus pallidus inputs to the subthalamic nucleus by the motor cortex.
Topics: Animals; Dopamine; GABAergic Neurons; gamma-Aminobutyric Acid; Globus Pallidus; Glutamic Acid; Long- | 2015 |
Striking the right balance: cortical modulation of the subthalamic nucleus-globus pallidus circuit.
Topics: Animals; Dopamine; gamma-Aminobutyric Acid; Globus Pallidus; Glutamic Acid; Motor Cortex; Neural Pat | 2015 |
Interaction between hyperdirect and indirect basal ganglia pathways.
Topics: Animals; Dopamine; gamma-Aminobutyric Acid; Globus Pallidus; Glutamic Acid; Motor Cortex; Neural Pat | 2015 |
Loss of Striatonigral GABAergic Presynaptic Inhibition Enables Motor Sensitization in Parkinsonian Mice.
Topics: Adrenergic Agents; Animals; Bacterial Proteins; Channelrhodopsins; Corpus Striatum; Disease Models, | 2015 |
Frequency-Dependent Corticostriatal Disinhibition Resulting from Chronic Dopamine Depletion: Role of Local Striatal cGMP and GABA-AR Signaling.
Topics: Animals; Brain Waves; Cerebral Cortex; Corpus Striatum; Cyclic GMP; Dopamine; Forelimb; gamma-Aminob | 2017 |
The novel 5-HT1A receptor agonist, NLX-112 reduces l-DOPA-induced abnormal involuntary movements in rat: A chronic administration study with microdialysis measurements.
Topics: Animals; Anti-Dyskinesia Agents; Corpus Striatum; Cross-Over Studies; Dopamine; Dose-Response Relati | 2016 |
The Role of Primary Motor Cortex (M1) Glutamate and GABA Signaling in l-DOPA-Induced Dyskinesia in Parkinsonian Rats.
Topics: Animals; Antiparkinson Agents; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, | 2016 |
Dopaminergic treatment weakens medium spiny neuron collateral inhibition in the parkinsonian striatum.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Female; gamma-Amin | 2017 |
6-OHDA-induced hemiparkinsonism and chronic L-DOPA treatment increase dopamine D1-stimulated [(3)H]-GABA release and [(3)H]-cAMP production in substantia nigra pars reticulata of the rat.
Topics: 1-Methyl-3-isobutylxanthine; Analysis of Variance; Animals; Antiparkinson Agents; Behavior, Animal; | 2008 |
Glutamatergic pallidothalamic projections and their implications in the pathophysiology of Parkinson's disease.
Topics: Animals; Dopamine; Down-Regulation; Efferent Pathways; Entopeduncular Nucleus; gamma-Aminobutyric Ac | 2008 |
Non-dopaminergic neurons in ventral mesencephalic transplants make widespread axonal connections in the host brain.
Topics: Animals; Animals, Newborn; Brain; Brain Tissue Transplantation; Cells, Cultured; Dopamine; Female; g | 2008 |
A multitarget basal ganglia dopaminergic and GABAergic transplantation strategy enhances behavioural recovery in parkinsonian rats.
Topics: Animals; Basal Ganglia; Dopamine; Female; Fetal Stem Cells; gamma-Aminobutyric Acid; Humans; Immunoh | 2008 |
Behavioral recovery in MPTP-treated monkeys: neurochemical mechanisms studied by intrastriatal microdialysis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Chlorocebus aethiops; Corpus Striatum; Di | 2008 |
The novel nociceptin/orphanin FQ receptor antagonist Trap-101 alleviates experimental parkinsonism through inhibition of the nigro-thalamic pathway: positive interaction with L-DOPA.
Topics: Animals; Antiparkinson Agents; Benzimidazoles; Disease Models, Animal; Dose-Response Relationship, D | 2008 |
Stimulation of delta opioid receptors located in substantia nigra reticulata but not globus pallidus or striatum restores motor activity in 6-hydroxydopamine lesioned rats: new insights into the role of delta receptors in parkinsonism.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzamides; Bicuculline; Bridged Bicyclo Compounds, | 2008 |
Dopamine D1 receptor gene expression studies in unilateral 6-hydroxydopamine-lesioned Parkinson's rat: effect of 5-HT, GABA, and bone marrow cell supplementation.
Topics: Adrenergic Agents; Animals; Bone Marrow Transplantation; Brain; Dopamine; gamma-Aminobutyric Acid; M | 2010 |
The novel delta opioid receptor agonist UFP-512 dually modulates motor activity in hemiparkinsonian rats via control of the nigro-thalamic pathway.
Topics: Amino Acids; Animals; Antiparkinson Agents; Benzimidazoles; Dose-Response Relationship, Drug; gamma- | 2009 |
Vasoactive intestinal peptide (VIP) treatment of Parkinsonian rats increases thalamic gamma-aminobutyric acid (GABA) levels and alters the release of nerve growth factor (NGF) by mast cells.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Female; gamma-Aminobutyric Acid; Heparin; Male; Mast Cells; | 2010 |
Endogenous nociceptin/orphanin FQ (N/OFQ) contributes to haloperidol-induced changes of nigral amino acid transmission and parkinsonism: a combined microdialysis and behavioral study in naïve and nociceptin/orphanin FQ receptor knockout mice.
Topics: Animals; Antipsychotic Agents; Benzimidazoles; Disease Models, Animal; Dose-Response Relationship, D | 2010 |
Changes in firing rate and pattern of GABAergic neurons in subregions of the substantia nigra pars reticulata in rat models of Parkinson's disease.
Topics: Action Potentials; Animals; Cell Count; Disease Models, Animal; gamma-Aminobutyric Acid; Male; Media | 2010 |
L-DOPA-induced dyskinesia in hemiparkinsonian rats is associated with up-regulation of adenylyl cyclase type V/VI and increased GABA release in the substantia nigra reticulata.
Topics: Adenylyl Cyclases; Animals; Dyskinesia, Drug-Induced; Enzyme Inhibitors; gamma-Aminobutyric Acid; Le | 2011 |
Striatal ablation of GABAergic neurons prevents the in vivo neuroprotective effect of DCG-IV against the MPP+-induced neurotoxicity on dopaminergic nerve terminals.
Topics: Animals; Corpus Striatum; Cyclopropanes; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid; | 2010 |
BL-1023 improves behavior and neuronal survival in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated mice.
Topics: Animals; Behavior, Animal; Brain; Cell Survival; Drug Combinations; gamma-Aminobutyric Acid; Immunoh | 2011 |
Striatal origin of the pathologic beta oscillations in Parkinson's disease.
Topics: Action Potentials; Animals; Beta Rhythm; Carbachol; Cholinergic Agonists; Dopamine; gamma-Aminobutyr | 2011 |
Striatal NTS1 , dopamine D2 and NMDA receptor regulation of pallidal GABA and glutamate release--a dual-probe microdialysis study in the intranigral 6-hydroxydopamine unilaterally lesioned rat.
Topics: Adrenergic Agents; Animals; Corpus Striatum; gamma-Aminobutyric Acid; Globus Pallidus; Glutamic Acid | 2012 |
Noisy galvanic vestibular stimulation promotes GABA release in the substantia nigra and improves locomotion in hemiparkinsonian rats.
Topics: Acoustic Stimulation; Animals; Behavior, Animal; Disease Models, Animal; Female; gamma-Aminobutyric | 2012 |
An in vivo ultrahigh field 14.1 T (1) H-MRS study on 6-OHDA and α-synuclein-based rat models of Parkinson's disease: GABA as an early disease marker.
Topics: alpha-Synuclein; Animals; Biomarkers; Brain; Early Diagnosis; Female; gamma-Aminobutyric Acid; Magne | 2013 |
Subthalamic lesion or levodopa treatment rescues giant GABAergic currents of PINK1-deficient striatum.
Topics: Animals; Antiparkinson Agents; Corpus Striatum; Electric Conductivity; Excitatory Amino Acid Agonist | 2012 |
Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat.
Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Biomarkers; Dopamine; Environm | 2002 |
GABA-opioid interactions in the globus pallidus: [D-Ala2]-Met-enkephalinamide attenuates potassium-evoked GABA release after nigrostriatal lesion.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Cats; Disease Models, Anima | 2002 |
Low cumulative manganese exposure affects striatal GABA but not dopamine.
Topics: Animals; Corpus Striatum; Dopamine; Drug Administration Schedule; Drug Synergism; Environmental Expo | 2002 |
Subthalamic GAD gene therapy in a Parkinson's disease rat model.
Topics: Animals; Dependovirus; Disease Models, Animal; Dopamine; Electric Stimulation; Electrophysiology; ga | 2002 |
Reversal of akinesia in experimental parkinsonism by GABA antagonist microinjections in the pedunculopontine nucleus.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Bicuculline; Cholinergic Fibers; Female; GABA | 2002 |
Stimulation of cannabinoid receptors reduces levodopa-induced dyskinesia in the MPTP-lesioned nonhuman primate model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Benserazide; Callithrix | 2002 |
[Mechanism of nootropic digam action in hypofunction of brain dopaminergic system].
Topics: Animals; Caudate Nucleus; Dopamine Antagonists; GABA Agents; gamma-Aminobutyric Acid; Haloperidol; N | 2003 |
Adenosinergic protection of dopaminergic and GABAergic neurons against mitochondrial inhibition through receptors located in the substantia nigra and striatum, respectively.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Corpus Str | 2003 |
Neurochemical mechanisms induced by high frequency stimulation of the subthalamic nucleus: increase of extracellular striatal glutamate and GABA in normal and hemiparkinsonian rats.
Topics: Animals; Corpus Striatum; Electric Stimulation; Extracellular Fluid; gamma-Aminobutyric Acid; Glutam | 2003 |
L-DOPA-induced modulation of GABA and glutamate release in substantia nigra pars reticulata in a rodent model of Parkinson's disease.
Topics: Animals; gamma-Aminobutyric Acid; Glutamic Acid; Levodopa; Male; Oxidopamine; Parkinsonian Disorders | 2004 |
Adenosine A(2A) receptor-mediated modulation of GABA and glutamate release in the output regions of the basal ganglia in a rodent model of Parkinson's disease.
Topics: Adenosine A2 Receptor Antagonists; Animals; Basal Ganglia; Denervation; Disease Models, Animal; Effe | 2004 |
Expression of GAD65 and GAD67 immunoreactivity in MPTP-treated monkeys with or without L-DOPA administration.
Topics: Animals; Basal Ganglia; Cell Count; Cerebral Cortex; Disease Models, Animal; Dopamine Agents; gamma- | 2005 |
Synaptic microcircuitry of tyrosine hydroxylase-containing neurons and terminals in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys.
Topics: Animals; Corpus Striatum; gamma-Aminobutyric Acid; Image Processing, Computer-Assisted; Macaca mulat | 2006 |
Cortical inputs and GABA interneurons imbalance projection neurons in the striatum of parkinsonian rats.
Topics: Animals; Cerebral Cortex; Corpus Striatum; gamma-Aminobutyric Acid; Interneurons; Neural Pathways; P | 2006 |
Adult human bone marrow stromal spheres express neuronal traits in vitro and in a rat model of Parkinson's disease.
Topics: Animals; Biomarkers; Bone Marrow Transplantation; Cell Death; Cell Differentiation; Cell Line; Cells | 2006 |
Subchronic administration of L-DOPA to adult rats with a unilateral 6-hydroxydopamine lesion of dopamine neurons results in a sensitization of enhanced GABA release in the substantia nigra, pars reticulata.
Topics: Animals; Antiparkinson Agents; Dopamine; Dopamine Agents; Drug Administration Schedule; gamma-Aminob | 2006 |
Unilateral 6-hydroxydopamine lesion of dopamine neurons and subchronic L-DOPA administration in the adult rat alters the expression of the vesicular GABA transporter in different subsets of striatal neurons and in the substantia nigra, pars reticulata.
Topics: Animals; Antiparkinson Agents; Corpus Striatum; Dopamine; Down-Regulation; Drug Administration Sched | 2007 |
The nociceptin/orphanin FQ receptor antagonist J-113397 and L-DOPA additively attenuate experimental parkinsonism through overinhibition of the nigrothalamic pathway.
Topics: Animals; Antiparkinson Agents; Benzimidazoles; Bicuculline; Drug Synergism; Drug Therapy, Combinatio | 2007 |
Interleukin-1beta mediates sleep alteration in rats with rotenone-induced parkinsonism.
Topics: Animals; Arousal; Brain; Brain Mapping; Dopamine; gamma-Aminobutyric Acid; Interleukin-1beta; Male; | 2007 |
Basal ganglia neurotransmitter concentrations in rhesus monkeys following subchronic manganese sulfate inhalation.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Basal Ganglia; Disease Models, Animal; Dopamine; gamma-Amin | 2007 |
Metabolic changes detected by proton magnetic resonance spectroscopy in vivo and in vitro in a murin model of Parkinson's disease, the MPTP-intoxicated mouse.
Topics: Animals; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid | 2008 |
Behavioral and biochemical correlates of the dyskinetic potential of dopaminergic agonists in the 6-OHDA lesioned rat.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antiparkinson Agents; Corpus St | 2008 |
Intrapallidal dopamine restores motor deficits induced by 6-hydroxydopamine in the rat.
Topics: Animals; Apomorphine; Benzazepines; Dopamine; Dopamine Agonists; Dopamine Antagonists; gamma-Aminobu | 2001 |
Effect of microiontophoretic application of dopamine on subthalamic nucleus neuronal activity in normal rats and in rats with unilateral lesion of the nigrostriatal pathway.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Action Potentials; Animals; Apomorphine; | 2001 |