gamma-aminobutyric acid has been researched along with Atherosclerotic Parkinsonism in 47 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study demonstrates that gabapentin improves rigidity, bradykinesia, and tremor of parkinsonism including both Parkinson's disease and Parkinson's syndrome." | 5.08 | Gabapentin for parkinsonism: a double-blind, placebo-controlled, crossover trial. ( Gruenthal, M; Mueller, ME; Olson, WH; Olson, WL, 1997) |
| "Gabapentin is a recently available anticonvulsant whose mechanism of action remains unknown." | 2.68 | Gabapentin for parkinsonism: a double-blind, placebo-controlled, crossover trial. ( Gruenthal, M; Mueller, ME; Olson, WH; Olson, WL, 1997) |
| "Tremor is currently ranked as the most common movement disorder." | 1.56 | Purkinje cell misfiring generates high-amplitude action tremors that are corrected by cerebellar deep brain stimulation. ( Brown, AM; Lin, T; Sillitoe, RV; van der Heijden, ME; White, JJ; Zhou, J, 2020) |
| "Manganese (Mn) is a well established neurotoxin associated with specific damage to the basal ganglia in humans." | 1.38 | Pathophysiology of manganese-associated neurotoxicity. ( Aschner, M; Criswell, SR; Dydak, U; Guilarte, TR; Racette, BA; Zheng, W, 2012) |
| "Ropinirole did not cause marked stereotypies." | 1.28 | Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist. ( Costall, B; Domeney, AM; Eden, RJ; Gerrard, PA; Harvey, CA; Kelly, ME; Naylor, RJ; Owen, DA; Wright, A, 1991) |
| "Ropinirole was weakly active at alpha 2-adrenoceptors and 5-HT2 receptors but inactive at 5-HT1, benzodiazepine and gamma-aminobutyric acid receptors or alpha 1 and beta-adrenoceptors." | 1.28 | Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist. ( Costall, B; Domeney, AM; Eden, RJ; Gerrard, PA; Harvey, CA; Kelly, ME; Naylor, RJ; Owen, DA; Wright, A, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (36.17) | 18.7374 |
| 1990's | 16 (34.04) | 18.2507 |
| 2000's | 5 (10.64) | 29.6817 |
| 2010's | 7 (14.89) | 24.3611 |
| 2020's | 2 (4.26) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, L | 1 |
| Ren, Y | 1 |
| Zeng, Z | 1 |
| Ren, H | 1 |
| Li, S | 1 |
| He, S | 1 |
| He, F | 1 |
| Li, X | 1 |
| Brown, AM | 1 |
| White, JJ | 1 |
| van der Heijden, ME | 1 |
| Zhou, J | 1 |
| Lin, T | 1 |
| Sillitoe, RV | 1 |
| Lyu, S | 1 |
| Guo, Y | 1 |
| Zhang, L | 1 |
| Wang, Y | 1 |
| Tang, G | 1 |
| Li, R | 1 |
| Yang, J | 1 |
| Gao, S | 1 |
| Ma, B | 1 |
| Liu, J | 1 |
| Lozovaya, N | 1 |
| Eftekhari, S | 1 |
| Cloarec, R | 1 |
| Gouty-Colomer, LA | 1 |
| Dufour, A | 1 |
| Riffault, B | 1 |
| Billon-Grand, M | 1 |
| Pons-Bennaceur, A | 1 |
| Oumar, N | 1 |
| Burnashev, N | 1 |
| Ben-Ari, Y | 1 |
| Hammond, C | 1 |
| Kim, SN | 1 |
| Doo, AR | 1 |
| Park, JY | 1 |
| Choo, HJ | 1 |
| Shim, I | 1 |
| Park, JJ | 1 |
| Chae, Y | 1 |
| Lee, B | 1 |
| Lee, H | 1 |
| Park, HJ | 1 |
| Cuomo, D | 1 |
| Martella, G | 1 |
| Barabino, E | 1 |
| Platania, P | 1 |
| Vita, D | 1 |
| Madeo, G | 1 |
| Selvam, C | 1 |
| Goudet, C | 1 |
| Oueslati, N | 1 |
| Pin, JP | 1 |
| Acher, F | 1 |
| Pisani, A | 1 |
| Beurrier, C | 1 |
| Melon, C | 1 |
| Kerkerian-Le Goff, L | 1 |
| Gubellini, P | 1 |
| Nandhu, MS | 1 |
| Paul, J | 1 |
| Kuruvilla, KP | 1 |
| Malat, A | 1 |
| Romeo, C | 1 |
| Paulose, CS | 1 |
| Bido, S | 1 |
| Marti, M | 1 |
| Morari, M | 1 |
| Du, J | 1 |
| Sun, ZL | 1 |
| Jia, J | 1 |
| Wang, X | 1 |
| Wang, XM | 1 |
| Racette, BA | 1 |
| Aschner, M | 1 |
| Guilarte, TR | 1 |
| Dydak, U | 1 |
| Criswell, SR | 1 |
| Zheng, W | 1 |
| McCormack, AL | 1 |
| Thiruchelvam, M | 1 |
| Manning-Bog, AB | 1 |
| Thiffault, C | 1 |
| Langston, JW | 1 |
| Cory-Slechta, DA | 1 |
| Di Monte, DA | 1 |
| Mytilineou, C | 1 |
| McNaught, KS | 1 |
| Shashidharan, P | 1 |
| Yabut, J | 1 |
| Baptiste, RJ | 1 |
| Parnandi, A | 1 |
| Olanow, CW | 1 |
| Zhao, XD | 1 |
| Zhou, XP | 1 |
| Liu, HH | 1 |
| Li, BM | 1 |
| Hu, XW | 1 |
| Li, FQ | 1 |
| You, BM | 1 |
| Casey, DE | 1 |
| Gerlach, J | 2 |
| Magelund, G | 1 |
| Christensen, TR | 1 |
| Logothetis, J | 1 |
| Paraschos, A | 1 |
| Frangos, E | 1 |
| Ananth, J | 1 |
| Lloyd, KG | 1 |
| Kopp, N | 1 |
| Jordan, D | 1 |
| Michel, JP | 1 |
| Pialat, J | 1 |
| Veisseire, M | 1 |
| Chazot, G | 1 |
| Tommasi, M | 1 |
| Levy, R | 2 |
| Herrero, MT | 3 |
| Ruberg, M | 2 |
| Villares, J | 1 |
| Faucheux, B | 2 |
| Guridi, J | 3 |
| Guillen, J | 2 |
| Luquin, MR | 3 |
| Javoy-Agid, F | 2 |
| Obeso, JA | 3 |
| Onofrj, M | 1 |
| Ferracci, F | 1 |
| Fulgente, T | 1 |
| Malatesta, G | 1 |
| Ghilardi, MF | 1 |
| Maneuf, YP | 2 |
| Mitchell, IJ | 1 |
| Crossman, AR | 4 |
| Brotchie, JM | 2 |
| Vila, M | 1 |
| Agid, Y | 1 |
| Hirsch, EC | 1 |
| Gerlach, M | 1 |
| Gsell, W | 1 |
| Kornhuber, J | 1 |
| Jellinger, K | 1 |
| Krieger, V | 1 |
| Pantucek, F | 1 |
| Vock, R | 1 |
| Riederer, P | 1 |
| Olson, WL | 1 |
| Gruenthal, M | 1 |
| Mueller, ME | 1 |
| Olson, WH | 1 |
| Winkler, C | 1 |
| Bentlage, C | 1 |
| Nikkhah, G | 1 |
| Samii, M | 1 |
| Björklund, A | 1 |
| Noda, S | 1 |
| Jackson-Lewis, V | 1 |
| Liberatore, G | 1 |
| Agostini, L | 1 |
| Firenze, C | 1 |
| Gallai, V | 1 |
| Piccinin, GL | 1 |
| Piccirilli, M | 1 |
| Rossi, A | 1 |
| Wolfarth, S | 1 |
| Eden, RJ | 1 |
| Costall, B | 1 |
| Domeney, AM | 1 |
| Gerrard, PA | 1 |
| Harvey, CA | 1 |
| Kelly, ME | 1 |
| Naylor, RJ | 1 |
| Owen, DA | 1 |
| Wright, A | 1 |
| Hikosaka, O | 1 |
| Robertson, RG | 2 |
| Graham, WC | 1 |
| Sambrook, MA | 2 |
| Snyder, SH | 1 |
| Clarke, CA | 1 |
| Boyce, S | 1 |
| Watanabe, R | 1 |
| Kish, SJ | 1 |
| Chang, LJ | 1 |
| Mirchandani, L | 1 |
| Shannak, K | 1 |
| Hornykiewicz, O | 1 |
| Arushanian, EB | 1 |
| Young, AB | 1 |
| Rondot, P | 2 |
| Bathien, N | 2 |
| Ziegler, M | 1 |
| Fournier, V | 1 |
| Morselli, PL | 1 |
| Brooks, BA | 1 |
| Fuchs, AF | 1 |
| Finocchio, D | 1 |
| Bennett, JP | 1 |
| Kosicka, B | 1 |
| Bugera, TE | 1 |
| Kittel, M | 1 |
| Smiałek, M | 1 |
| Carotti, A | 1 |
| Tomassetti, G | 1 |
| Lucciarini, L | 1 |
| Barone, G | 1 |
| Mugnai, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Double-blind Placebo-controlled Multicenter Proof-of-concept Trial to Assess the Efficacy and Safety of Bumetanide in Parkinson's Disease[NCT03899324] | Phase 2 | 40 participants (Anticipated) | Interventional | 2019-04-26 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for gamma-aminobutyric acid and Atherosclerotic Parkinsonism
| Article | Year |
|---|---|
Current psychopathological theories of tardive dyskinesia and their implications for future research.
Topics: Acetylcholine; Adult; Aged; Animals; Antipsychotic Agents; Brain; Dopamine; Dyskinesia, Drug-Induced | 1982 |
The neuropathology of GABA neurons in extrapyramidal disorders.
Topics: Basal Ganglia Diseases; gamma-Aminobutyric Acid; Humans; Huntington Disease; Neurons; Parkinson Dise | 1980 |
[Delayed type malignant syndrome and Parkinson's syndrome due to tiapride, Reye-like syndrome induced by calcium hopantenate].
Topics: Animals; Antipsychotic Agents; Diagnosis, Differential; gamma-Aminobutyric Acid; Humans; Neuroleptic | 1999 |
Experimental basis of the therapy of Parkinson's disease and the cholinergic-dopaminergic equilibrium in basal brain nuclei.
Topics: Animals; Apomorphine; Basal Ganglia Diseases; Behavior, Animal; Brain; Carbachol; Caudate Nucleus; C | 1976 |
[Neuroleptic parkinsonism and tardive dyskinesia and methods of pharmacologically correcting these pathologic conditions (review)].
Topics: Animals; Antipsychotic Agents; Cats; Cholinergic Fibers; Corpus Striatum; Dopamine; Dyskinesia, Drug | 1985 |
4 trials available for gamma-aminobutyric acid and Atherosclerotic Parkinsonism
| Article | Year |
|---|---|
gamma-Acetylenic GABA in tardive dyskinesia.
Topics: 4-Aminobutyrate Transaminase; Adult; Aged; Alkynes; Aminocaproates; Antipsychotic Agents; Brain; Dop | 1980 |
Gabapentin for parkinsonism: a double-blind, placebo-controlled, crossover trial.
Topics: Acetates; Adult; Aged; Amines; Antiparkinson Agents; Cross-Over Studies; Cyclohexanecarboxylic Acids | 1997 |
Movement disorders in patients with coexistent neuroleptic-induced tremor and tardive dyskinesia: EMG and pharmacological study.
Topics: Antipsychotic Agents; Clinical Trials as Topic; Corpus Striatum; Double-Blind Method; Dyskinesia, Dr | 1987 |
Therapeutic response to progabide in neuroleptic- and L-dopa-induced dyskinesias.
Topics: Adult; Aged; Antipsychotic Agents; Clinical Trials as Topic; Double-Blind Method; Dyskinesia, Drug-I | 1987 |
38 other studies available for gamma-aminobutyric acid and Atherosclerotic Parkinsonism
| Article | Year |
|---|---|
Comparative study of striatum GABA concentrations and magnetic resonance spectroscopic imaging in Parkinson's disease monkeys.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Chromatography, High Pressure Liquid; Corpus | 2019 |
Purkinje cell misfiring generates high-amplitude action tremors that are corrected by cerebellar deep brain stimulation.
Topics: Animals; Cerebellum; Deep Brain Stimulation; Female; gamma-Aminobutyric Acid; Harmaline; Male; Mice; | 2020 |
Blockade of GABA transporter-1 and GABA transporter-3 in the lateral habenula improves depressive-like behaviors in a rat model of Parkinson's disease.
Topics: Animals; Anisoles; Behavior, Animal; Depression; Dopamine; Dose-Response Relationship, Drug; Electro | 2020 |
GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease.
Topics: Acetylcholine; Action Potentials; Animals; Bumetanide; Chlorides; Cholinergic Agents; Cholinergic Ne | 2018 |
Combined treatment with acupuncture reduces effective dose and alleviates adverse effect of L-dopa by normalizing Parkinson's disease-induced neurochemical imbalance.
Topics: Acupuncture Therapy; Animals; Antiparkinson Agents; Brain Chemistry; Combined Modality Therapy; gamm | 2014 |
Metabotropic glutamate receptor subtype 4 selectively modulates both glutamate and GABA transmission in the striatum: implications for Parkinson's disease treatment.
Topics: Aminobutyrates; Animals; Antiparkinson Agents; Dose-Response Relationship, Drug; Electrophysiology; | 2009 |
Enhanced glutamate, IP3 and cAMP activity in the cerebral cortex of unilateral 6-hydroxydopamine induced Parkinson's rats: effect of 5-HT, GABA and bone marrow cell supplementation.
Topics: Animals; Behavior, Animal; Bone Marrow Cells; Bone Marrow Transplantation; Cerebral Cortex; Cyclic A | 2011 |
Amantadine attenuates levodopa-induced dyskinesia in mice and rats preventing the accompanying rise in nigral GABA levels.
Topics: Amantadine; Animals; Antiparkinson Agents; Behavior, Animal; Data Interpretation, Statistical; Dyski | 2011 |
[High-frequency electro-acupuncture stimulation modulates intracerebral γ-aminobutyric acid content in rat model of Parkinson's disease].
Topics: Acupuncture Therapy; Animals; Brain; Electroacupuncture; gamma-Aminobutyric Acid; Male; Motor Cortex | 2011 |
Pathophysiology of manganese-associated neurotoxicity.
Topics: Air Pollutants, Occupational; Animals; Aspartic Acid; Brain; Dopamine; gamma-Aminobutyric Acid; Huma | 2012 |
Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat.
Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Biomarkers; Dopamine; Environm | 2002 |
Inhibition of proteasome activity sensitizes dopamine neurons to protein alterations and oxidative stress.
Topics: Acetylcysteine; Animals; Canavanine; Cell Survival; Cells, Cultured; Cysteine Proteinase Inhibitors; | 2004 |
[Changes of amino acids neurotransmitters in striatum of hemi-parkinsonian rhesus monkey after high frequency stimulation of subthalamic nucleus].
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amino Acids; Animals; Chromatography, High Pressure Li | 2007 |
Side effects in preventive maintenance therapy with neuroleptics with special emphasis on tardive dyskinesia.
Topics: Antipsychotic Agents; Chronic Disease; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Humans; Pa | 1981 |
[Topographic and chemical study of the GABA synthetizing enzyme in Parkinsonian syndromes].
Topics: Aged; Brain; Brain Chemistry; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; Male | 1983 |
Effects of nigrostriatal denervation and L-dopa therapy on the GABAergic neurons in the striatum in MPTP-treated monkeys and Parkinson's disease: an in situ hybridization study of GAD67 mRNA.
Topics: Aged; Aged, 80 and over; Animals; Corpus Striatum; Denervation; gamma-Aminobutyric Acid; Glutamate D | 1995 |
Effects of drug manipulations on anterior components of somatosensory evoked potentials in a parkinsonian animal model.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cholinergic Antagonists; Electric Stimulation | 1994 |
On the role of enkephalin cotransmission in the GABAergic striatal efferents to the globus pallidus.
Topics: Animals; Bicuculline; Corpus Striatum; Drug Combinations; Efferent Pathways; Enkephalins; gamma-Amin | 1994 |
Origin of chorea-ballism and multisystem degeneration: pathophysiological implications.
Topics: Animals; Basal Ganglia Diseases; Chorea; Dopamine; Dystonia; gamma-Aminobutyric Acid; Globus Pallidu | 1993 |
Consequences of nigrostriatal denervation on the gamma-aminobutyric acidic neurons of substantia nigra pars reticulata and superior colliculus in parkinsonian syndromes.
Topics: Animals; Corpus Striatum; Denervation; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hum | 1996 |
A post mortem study on neurochemical markers of dopaminergic, GABA-ergic and glutamatergic neurons in basal ganglia-thalamocortical circuits in Parkinson syndrome.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Aged, 80 and over; Basal Ganglia; Biomarkers; Cerebral Cortex; | 1996 |
The cannabinoid receptor agonist WIN 55,212-2 reduces D2, but not D1, dopamine receptor-mediated alleviation of akinesia in the reserpine-treated rat model of Parkinson's disease.
Topics: Animals; Basal Ganglia; Benzazepines; Benzoxazines; Dopamine Agonists; gamma-Aminobutyric Acid; Loco | 1997 |
Intranigral transplants of GABA-rich striatal tissue induce behavioral recovery in the rat Parkinson model and promote the effects obtained by intrastriatal dopaminergic transplants.
Topics: Animals; Apomorphine; Brain Tissue Transplantation; Cell Count; Dopamine; Dopamine Agonists; Female; | 1999 |
Effects of a unilateral stereotaxic injection of Tinuvin 123 into the substantia nigra on the nigrostriatal dopaminergic pathway in the rat.
Topics: Animals; Astrocytes; Behavior, Animal; Calcium Channel Blockers; Decanoic Acids; Dopamine; Environme | 2000 |
[Neurochemical aspects of Parkinson tremor].
Topics: Antiparkinson Agents; gamma-Aminobutyric Acid; Histamine; Humans; Levodopa; Parkinson Disease, Secon | 1979 |
Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenylyl Cyclases; Animals; Antiparkinson Agents; Bloo | 1991 |
Dopamine and basal ganglia.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Basal Ganglia; Dopamine; gamma-Aminobutyric A | 1991 |
Further investigations into the pathophysiology of MPTP-induced parkinsonism in the primate: an intracerebral microdialysis study of gamma-aminobutyric acid in the lateral segment of the globus pallidus.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Chromatography, High Pressure Liquid; Dialysi | 1991 |
Parkinson's disease. Fresh factors to consider.
Topics: Animals; DNA; Dopamine; gamma-Aminobutyric Acid; MPTP Poisoning; Nerve Growth Factors; Nerve Tissue | 1991 |
The role of striatopallidal neurones utilizing gamma-aminobutyric acid in the pathophysiology of MPTP-induced parkinsonism in the primate: evidence from [3H]flunitrazepam autoradiography.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Brain; Carbidopa; Corpus Str | 1990 |
[Consciousness disorders in the aged due to therapeutic drugs].
Topics: Aged; Anemia; Cognition Disorders; Consciousness Disorders; Drug Interactions; Flunarizine; gamma-Am | 1990 |
Progressive supranuclear palsy: relationship between extrapyramidal disturbances, dementia, and brain neurotransmitter markers.
Topics: Aged; Aspartic Acid; Basal Ganglia Diseases; Brain; Bulbar Palsy, Progressive; Choline O-Acetyltrans | 1985 |
Pathophysiological mechanisms underlying tardive dyskinesia.
Topics: Antipsychotic Agents; Basal Ganglia Diseases; Brain; Dyskinesia, Drug-Induced; gamma-Aminobutyric Ac | 1985 |
Progressive supranuclear palsy: postmortem chemical analysis.
Topics: Basal Ganglia; Brain; Bulbar Palsy, Progressive; Choline O-Acetyltransferase; Dopamine; gamma-Aminob | 1985 |
Saccadic eye movement deficits in the MPTP monkey model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Eye Movements; gamma- | 1986 |
Striatal dopamine depletion, dopamine receptor stimulation, and GABA metabolism: implications for the therapy of Parkinson's disease.
Topics: Animals; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hydroxydopamin | 1986 |
[Gamma-aminobutyric acid (GABA) levels and glutamate decarboxylase (GAD) activity of the brain of rats with extrapyramidal syndrome after acute manganese chloride poisoning].
Topics: Acute Disease; Brain Chemistry; Chlorides; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; | 1985 |
[Trial use of L-dopa associated with a dopa-decarboxylase inhibitor in Parkinson's syndrome].
Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Diphenhydramine; Drug Therapy, Combination; g | 1974 |