gamma-aminobutyric acid has been researched along with Arthralgia in 11 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Arthralgia: Pain in the joint.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We found that 24-h after CFA-induced knee inflammation, knee neurons show a decreased action potential generation threshold, as well as increased GABA and capsaicin sensitivity, but have unaltered acid sensitivity." | 3.88 | Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner. ( Callejo, G; Chakrabarti, S; Hockley, JRF; Pattison, LA; Singhal, K; Smith, ESJ, 2018) |
| "Although joint pain is common, its mechanisms remain undefined, with little known about the spinal neuronal responses that contribute to this type of pain." | 1.39 | Gabapentin alleviates facet-mediated pain in the rat through reduced neuronal hyperexcitability and astrocytic activation in the spinal cord. ( Crosby, ND; Dong, L; Winkelstein, BA, 2013) |
| "This study supports that facet joint pain is sustained through spinal neuronal and astrocytic activation." | 1.39 | Gabapentin alleviates facet-mediated pain in the rat through reduced neuronal hyperexcitability and astrocytic activation in the spinal cord. ( Crosby, ND; Dong, L; Winkelstein, BA, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (63.64) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chakrabarti, S | 1 |
| Pattison, LA | 1 |
| Singhal, K | 1 |
| Hockley, JRF | 1 |
| Callejo, G | 1 |
| Smith, ESJ | 1 |
| Dong, L | 2 |
| Crosby, ND | 2 |
| Winkelstein, BA | 2 |
| Zaucke, F | 1 |
| Kras, JV | 1 |
| Luo, ZD | 1 |
| Bas, DB | 1 |
| Su, J | 1 |
| Sandor, K | 1 |
| Agalave, NM | 1 |
| Lundberg, J | 1 |
| Codeluppi, S | 1 |
| Baharpoor, A | 1 |
| Nandakumar, KS | 1 |
| Holmdahl, R | 1 |
| Svensson, CI | 1 |
| Arvio, M | 1 |
| Merikanto, J | 1 |
| Nguyen, VH | 1 |
| Lawrence, HJ | 1 |
| Simjee, SU | 1 |
| Pleuvry, BJ | 1 |
| Coulthard, P | 1 |
| Almahrezi, A | 1 |
| Fitzcharles, MA | 1 |
| Bove, SE | 1 |
| Laemont, KD | 1 |
| Brooker, RM | 1 |
| Osborn, MN | 1 |
| Sanchez, BM | 1 |
| Guzman, RE | 1 |
| Hook, KE | 1 |
| Juneau, PL | 1 |
| Connor, JR | 1 |
| Kilgore, KS | 1 |
| Ferreira-Gomes, J | 1 |
| Neto, FL | 1 |
| Castro-Lopes, JM | 1 |
| Rovetta, G | 1 |
| Baratto, L | 1 |
| Farinelli, G | 1 |
| Monteforte, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Exploratory Study on the Use of Pregabalin for the Treatment of Taxol Related Arthralgia-Myalgia[NCT02024568] | Phase 2 | 38 participants (Anticipated) | Interventional | 2013-12-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 other studies available for gamma-aminobutyric acid and Arthralgia
| Article | Year |
|---|---|
Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Capsaicin; Cells, Cultured; Disease Mo | 2018 |
Gabapentin alleviates facet-mediated pain in the rat through reduced neuronal hyperexcitability and astrocytic activation in the spinal cord.
Topics: Amines; Analgesics; Animals; Arthralgia; Astrocytes; Cyclohexanecarboxylic Acids; Gabapentin; gamma- | 2013 |
Thrombospondin-4 and excitatory synaptogenesis promote spinal sensitization after painful mechanical joint injury.
Topics: Action Potentials; Amines; Analgesics; Animals; Arthralgia; Cyclohexanecarboxylic Acids; Excitatory | 2015 |
Collagen antibody-induced arthritis evokes persistent pain with spinal glial involvement and transient prostaglandin dependency.
Topics: Amines; Analgesics; Animals; Arthralgia; Arthritis, Experimental; Buprenorphine; Cyclohexanecarboxyl | 2012 |
[A relief from neural pain--gabapentin helped against hip ache in a girl with cerebral palsy].
Topics: Acetates; Adolescent; Amines; Analgesics; Arthralgia; Cerebral Palsy; Cyclohexanecarboxylic Acids; F | 2001 |
Use of gabapentin in the prevention of taxane-induced arthralgias and myalgias.
Topics: Acetates; Amines; Analgesics; Antineoplastic Agents, Phytogenic; Arthralgia; Cyclohexanecarboxylic A | 2004 |
Modulation of the gait deficit in arthritic rats by infusions of muscimol and bicuculline.
Topics: Animals; Arthralgia; Arthritis, Experimental; Body Weight; Disease Models, Animal; Dose-Response Rel | 2004 |
Dose-dependent severe arthralgia induced by gabapentin.
Topics: Acetates; Adult; Amines; Anticonvulsants; Arthralgia; Cyclohexanecarboxylic Acids; Female; Gabapenti | 2004 |
Surgically induced osteoarthritis in the rat results in the development of both osteoarthritis-like joint pain and secondary hyperalgesia.
Topics: Amines; Analgesics; Animals; Arthralgia; Cyclohexanecarboxylic Acids; Cyclooxygenase 2 Inhibitors; D | 2006 |
GABA(B2) receptor subunit mRNA decreases in the thalamus of monoarthritic animals.
Topics: Afferent Pathways; Animals; Arthralgia; Arthritis; Chronic Disease; Disease Models, Animal; Down-Reg | 2006 |
Three-month follow-up of shoulder-hand syndrome induced by phenobarbital and treated with gabapentin.
Topics: Acetaminophen; Acetates; Amines; Analgesics; Anticonvulsants; Arthralgia; Cyclohexanecarboxylic Acid | 2001 |