Page last updated: 2024-10-16

gamma-aminobutyric acid and Amentia

gamma-aminobutyric acid has been researched along with Amentia in 68 studies

gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.

Research Excerpts

ExcerptRelevanceReference
"Twelve patients with moderate to severe dementia and severe behavioral disorders were treated with open-label gabapentin (200-1,200 mg/day) for 8 weeks in a prospective case-series design."9.09Effectiveness of gabapentin for the treatment of behavioral disorders in dementia. ( Herrmann, N; Lanctôt, K; Myszak, M, 2000)
" Controlled trials in elderly patients with epilepsy demonstrate efficacy and tolerability comparable to gabapentin."8.84Lamotrigine therapy in elderly patients with epilepsy, bipolar disorder or dementia. ( Nanry, K; Ramsay, E; Sajatovic, M; Thompson, T, 2007)
"Reports of lamotrigine therapy in elderly patients with epilepsy, bipolar disorder (BD), or dementia were identified by conducting an electronic search of major publication databases."8.84Lamotrigine therapy in elderly patients with epilepsy, bipolar disorder or dementia. ( Nanry, K; Ramsay, E; Sajatovic, M; Thompson, T, 2007)
"Review of the available literature suggests lamotrigine is effective and well tolerated in elderly patients with epilepsy and relatively well-tolerated and may be effective in delaying mood relapse, particularly in the depressive pole, in patients with BD."8.84Lamotrigine therapy in elderly patients with epilepsy, bipolar disorder or dementia. ( Nanry, K; Ramsay, E; Sajatovic, M; Thompson, T, 2007)
"Our patient, a 77-year-old Czech woman with incipient vascular dementia, received gabapentin 400mg at bedtime for 6 months and showed convincing improvement."7.77Gabapentin in the treatment of dementia-associated nocturnal agitation. ( Busek, P; Buskova, J; Nevsimalova, S, 2011)
"In a 24-patient case series from retrospective chart review, the authors examined the use of gabapentin for the treatment of aggressive and agitated behaviors in nursing home patients with a DSM-IV diagnosis of dementia."7.70A retrospective chart review of gabapentin for the treatment of aggressive and agitated behavior in patients with dementias. ( Hawkins, JW; Peyser, CE; Sheikh, JI; Tinklenberg, JR; Yesavage, JA, 2000)
"Gabapentin was generally well tolerated in this population."6.69Effectiveness of gabapentin for the treatment of behavioral disorders in dementia. ( Herrmann, N; Lanctôt, K; Myszak, M, 2000)
"Gabapentin was very effective in treating nocturnal agitation."5.37Gabapentin in the treatment of dementia-associated nocturnal agitation. ( Busek, P; Buskova, J; Nevsimalova, S, 2011)
" According to a predefined scheme for 8 weeks, all patients in the intervention group received individual daily pain treatment with acetaminophen, extended release morphine, buprenorphine transdermal patch, and/or pregabaline."5.19The response of agitated behavior to pain management in persons with dementia. ( Aarsland, D; Ballard, C; Cohen-Mansfield, J; Husebo, BS; Seifert, R, 2014)
"Pain medication significantly improved pain in the intervention group, with indications that acetaminophen also improved ADL function."5.19Impact of a stepwise protocol for treating pain on pain intensity in nursing home patients with dementia: a cluster randomized trial. ( Aarsland, D; Ballard, C; Corbett, A; Husebo, BS; Sandvik, RK; Seifert, R; Selbaek, G, 2014)
"Twelve patients with moderate to severe dementia and severe behavioral disorders were treated with open-label gabapentin (200-1,200 mg/day) for 8 weeks in a prospective case-series design."5.09Effectiveness of gabapentin for the treatment of behavioral disorders in dementia. ( Herrmann, N; Lanctôt, K; Myszak, M, 2000)
" The purpose of this review of the literature is to assess the interest and the limits of anticonvulsant mood stabilizers (carbamazepine, valproic acid, gabapentin, lamotrigine, topiramate, oxcarbazepine) in the treatment of the so-called "noncognitive" symptoms of dementia."4.84[Anticonvulsant mood stabilizers in the treatment of behavioral and psychological symptoms of dementia (BPSD)]. ( Pinheiro, D, 2008)
"Among these medications, only carbamazepine demonstrated its efficacy in behavioral and psychological symptoms of dementia (BPSD) in controlled studies, notably that of Tariot et al."4.84[Anticonvulsant mood stabilizers in the treatment of behavioral and psychological symptoms of dementia (BPSD)]. ( Pinheiro, D, 2008)
" Controlled trials in elderly patients with epilepsy demonstrate efficacy and tolerability comparable to gabapentin."4.84Lamotrigine therapy in elderly patients with epilepsy, bipolar disorder or dementia. ( Nanry, K; Ramsay, E; Sajatovic, M; Thompson, T, 2007)
"Reports of lamotrigine therapy in elderly patients with epilepsy, bipolar disorder (BD), or dementia were identified by conducting an electronic search of major publication databases."4.84Lamotrigine therapy in elderly patients with epilepsy, bipolar disorder or dementia. ( Nanry, K; Ramsay, E; Sajatovic, M; Thompson, T, 2007)
"Review of the available literature suggests lamotrigine is effective and well tolerated in elderly patients with epilepsy and relatively well-tolerated and may be effective in delaying mood relapse, particularly in the depressive pole, in patients with BD."4.84Lamotrigine therapy in elderly patients with epilepsy, bipolar disorder or dementia. ( Nanry, K; Ramsay, E; Sajatovic, M; Thompson, T, 2007)
"To review and summarize the currently available data on the use of anticonvulsant mood stabilizers (carbamazepine, valproic acid, gabapentin, lamotrigine, topiramate) in the treatment of behavioral and psychological symptoms of dementia (BPSD); to determine whether these medications can be recommended for routine clinical use."4.84Anticonvulsants for the treatment of behavioral and psychological symptoms of dementia: a literature review. ( Konovalov, S; Muralee, S; Tampi, RR, 2008)
"Our patient, a 77-year-old Czech woman with incipient vascular dementia, received gabapentin 400mg at bedtime for 6 months and showed convincing improvement."3.77Gabapentin in the treatment of dementia-associated nocturnal agitation. ( Busek, P; Buskova, J; Nevsimalova, S, 2011)
"In a 24-patient case series from retrospective chart review, the authors examined the use of gabapentin for the treatment of aggressive and agitated behaviors in nursing home patients with a DSM-IV diagnosis of dementia."3.70A retrospective chart review of gabapentin for the treatment of aggressive and agitated behavior in patients with dementias. ( Hawkins, JW; Peyser, CE; Sheikh, JI; Tinklenberg, JR; Yesavage, JA, 2000)
"In addition, restlessness and pacing were sensible to analgesics."2.79The response of agitated behavior to pain management in persons with dementia. ( Aarsland, D; Ballard, C; Cohen-Mansfield, J; Husebo, BS; Seifert, R, 2014)
"Pain is frequent and distressing in people with dementia, but no randomized controlled trials have evaluated the effect of analgesic treatment on pain intensity as a key outcome."2.79Impact of a stepwise protocol for treating pain on pain intensity in nursing home patients with dementia: a cluster randomized trial. ( Aarsland, D; Ballard, C; Corbett, A; Husebo, BS; Sandvik, RK; Seifert, R; Selbaek, G, 2014)
"Gabapentin was generally well tolerated in this population."2.69Effectiveness of gabapentin for the treatment of behavioral disorders in dementia. ( Herrmann, N; Lanctôt, K; Myszak, M, 2000)
"Dementia is a progressive neurodegenerative disorder with cognitive dysfunction, and is often complicated by behavioral and psychological symptoms of dementia (BPSD) including excitement, aggression, and hallucinations."2.53Neuropharmacological efficacy of the traditional Japanese Kampo medicine yokukansan and its active ingredients. ( Ikarashi, Y; Mizoguchi, K, 2016)
"Manganese (Mn) is an essential trace element that is required for maintaining proper function and regulation of numerous biochemical and cellular reactions."2.49Manganese toxicity in the central nervous system: the glutamine/glutamate-γ-aminobutyric acid cycle. ( Aschner, M; Sidoryk-Wegrzynowicz, M, 2013)
" Despite its essentiality, at excessive levels Mn is toxic to the central nervous system (CNS)."2.49Manganese toxicity in the central nervous system: the glutamine/glutamate-γ-aminobutyric acid cycle. ( Aschner, M; Sidoryk-Wegrzynowicz, M, 2013)
"Gabapentin was very effective in treating nocturnal agitation."1.37Gabapentin in the treatment of dementia-associated nocturnal agitation. ( Busek, P; Buskova, J; Nevsimalova, S, 2011)
"These observations suggest that in Alzheimer's disease there are no major changes in the extracellular concentrations of these putative amino acid transmitters."1.27Amino acid release from biopsy samples of temporal neocortex from patients with Alzheimer's disease. ( Bowen, DM; Davison, AN; Neary, D; Sims, NR; Smith, CC, 1983)
"gamma-Aminobutyric acid (GABA) was measured in CSF as such and following acid hydrolysis by the ion-exchange/fluorometric method."1.27Free and conjugated GABA in human cerebrospinal fluid: effect of degenerative neurologic diseases and isoniazid. ( Manyam, BV; Tremblay, RD, 1984)
"In patients with Huntington's disease, on administration of isoniazid at 900 mg/day, along with pyridoxine at 100 mg/day, a 4-fold increase of both free (P less than 0."1.27Free and conjugated GABA in human cerebrospinal fluid: effect of degenerative neurologic diseases and isoniazid. ( Manyam, BV; Tremblay, RD, 1984)
"Neuropathologically, Huntington's disease is characterized by a profound reduction in neuronal cells originating in the corpus striatum and globus pallidus."1.26Cerebrospinal fluid gamma-aminobutyric acid variations in neurological disorders. ( Enna, SJ; Stern, LZ; Wastek, GJ; Yamamura, HI, 1977)

Research

Studies (68)

TimeframeStudies, this research(%)All Research%
pre-199039 (57.35)18.7374
1990's4 (5.88)18.2507
2000's14 (20.59)29.6817
2010's11 (16.18)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Shalev, D1
Arbuckle, MR1
Gilbert, N1
Husebo, BS2
Ballard, C2
Cohen-Mansfield, J1
Seifert, R2
Aarsland, D2
Sandvik, RK1
Selbaek, G1
Corbett, A1
Breivik, H1
Ikarashi, Y1
Mizoguchi, K1
Pinheiro, D1
Hagino, T1
Ochiai, S1
Sato, E1
Watanabe, Y1
Senga, S1
Haro, H1
Jeong, DU1
Chang, WS1
Hwang, YS1
Lee, D1
Chang, JW1
Buskova, J1
Busek, P1
Nevsimalova, S1
Nilsen, LH1
Rae, C1
Ittner, LM1
Götz, J1
Sonnewald, U1
Sidoryk-Wegrzynowicz, M1
Aschner, M1
FEITELEVICH, J1
ZIPILIVAN, M1
Moretti, R1
Torre, P1
Antonello, RM1
Cazzato, G1
Bava, A1
Inada, K1
Ishigooka, J1
Horvath, J1
Coeytaux, A1
Jallon, P1
Landis, T1
Temperli, P1
Burkhard, PR1
Sajatovic, M1
Ramsay, E1
Nanry, K1
Thompson, T1
Bhat, R1
Rockwood, K1
Konovalov, S1
Muralee, S1
Tampi, RR1
Rueda, N1
Flórez, J1
Martínez-Cué, C1
Talarovicova, A1
Krskova, L1
Kiss, A1
McGeer, EG2
McGeer, PL1
Rossor, MN4
Emson, PC1
Mountjoy, CQ3
Roth, M3
Iversen, LL3
Smith, CC1
Bowen, DM3
Sims, NR1
Neary, D1
Davison, AN4
Davies, P2
Greenwald, BS1
Davis, KL1
Coyle, JT1
Singer, H1
McKinney, M1
Price, D1
Bareggi, SR1
Franceschi, M1
Bonini, L1
Zecca, L1
Smirne, S1
Kuroda, H1
Barbosa, ER1
Marchiori, PE1
Scaff, M1
de Assis, JL1
Manyam, BV1
Tremblay, RD1
Cross, AJ1
Crow, TJ1
Ferrier, IN1
Johnson, JA1
Markakis, D1
Manyam, NV1
Katz, L1
Hare, TA1
Gerber, JC1
Grossman, MH1
Zimmer, R1
Teelken, AW1
Trieling, WB1
Weber, W1
Weihmayr, T1
Lauter, H1
Roberts, E1
Garrett, NJ1
Johnson, AL1
Tarbit, I1
Perry, EK1
Perry, RH1
Blessed, G1
Tomlinson, BE1
Sheldon, LJ1
Ancill, RJ1
Holliday, SG1
Goldenberg, G1
Kahaner, K1
Basavaraju, N1
Rangu, S1
Herrmann, N1
Lanctôt, K1
Myszak, M1
Hawkins, JW1
Tinklenberg, JR1
Sheikh, JI1
Peyser, CE1
Yesavage, JA1
Lindenmayer, JP1
Inoue, T1
Wang, F1
Moriguchi, A1
Shirakawa, K1
Matsuoka, N1
Goto, T1
Rossi, P1
Serrao, M1
Pozzessere, G1
Toru, M1
Spillane, JA1
Goodhart, MJ1
White, P1
Terry, RD1
Achar, VS1
Welch, KM1
Chabi, E1
Bartosh, K1
Meyer, JS1
Enna, SJ2
Stern, LZ1
Wastek, GJ1
Yamamura, HI2
McNamara, JO1
Appel, SH1
Reisine, TD1
Bird, ED1
Spokes, E1
Tosca, P1
Canevari, L1
Di Paolo, E1
Ferrari, R1
Verzé, S1
Zerbi, F1
Dagani, F1
Reynolds, GP1
Pearson, SJ1
Heathfield, KW1
Kish, SJ1
Chang, LJ1
Mirchandani, L1
Shannak, K1
Hornykiewicz, O1
Kanazawa, I1
Kwak, S1
Sasaki, H1
Muramoto, O1
Mizutani, T1
Hori, A1
Nukina, N1
Pomara, N1
Deptula, D1
Galloway, MP1
LeWitt, PA1
Stanley, M1
Jones, EG1
Mirsky, AF1
Duncan, CC1
Myslobodsky, MS1
Nakahiro, M1
Mochizuki, D1
Uchida, S1
Yoshida, H1
Otomo, E1
Noda, S1
Umezaki, H1
Yamamoto, K1
Araki, T1
Murakami, T1
Ishii, N1
Nakamura, S1
Kameyama, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Impact of Pain on Behavioural Disturbances in Patients With Moderate and Severe Dementia. A Cluster Randomized Trial[NCT01021696]Phase 2/Phase 3352 participants (Actual)Interventional2009-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

18 reviews available for gamma-aminobutyric acid and Amentia

ArticleYear
Neuropharmacological efficacy of the traditional Japanese Kampo medicine yokukansan and its active ingredients.
    Pharmacology & therapeutics, 2016, Volume: 166

    Topics: Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Catecholamines; Dementia; Drugs, Chinese Herbal

2016
[Anticonvulsant mood stabilizers in the treatment of behavioral and psychological symptoms of dementia (BPSD)].
    L'Encephale, 2008, Volume: 34, Issue:4

    Topics: Aged; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dementia; Fructose; Gabap

2008
Manganese toxicity in the central nervous system: the glutamine/glutamate-γ-aminobutyric acid cycle.
    Journal of internal medicine, 2013, Volume: 273, Issue:5

    Topics: Central Nervous System; Dementia; Evidence-Based Medicine; gamma-Aminobutyric Acid; Glutamic Acid; G

2013
[Dementia induced by antianxiety drugs].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl

    Topics: Aging; Anti-Anxiety Agents; Benzodiazepines; Chlorides; Dementia; GABA-A Receptor Agonists; gamma-Am

2004
Lamotrigine therapy in elderly patients with epilepsy, bipolar disorder or dementia.
    International journal of geriatric psychiatry, 2007, Volume: 22, Issue:10

    Topics: Aged; Aged, 80 and over; Amines; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine;

2007
Anticonvulsants for the treatment of behavioral and psychological symptoms of dementia: a literature review.
    International psychogeriatrics, 2008, Volume: 20, Issue:2

    Topics: Aggression; Amines; Anticonvulsants; Carbamazepine; Cognition Disorders; Cyclohexanecarboxylic Acids

2008
Some assessments of the amygdala role in suprahypothalamic neuroendocrine regulation: a minireview.
    Endocrine regulations, 2007, Volume: 41, Issue:4

    Topics: Alzheimer Disease; Amygdala; Anxiety Disorders; Autistic Disorder; Corticotropin-Releasing Hormone;

2007
Neurotransmitter systems in aging and senile dementia.
    Progress in neuro-psychopharmacology, 1981, Volume: 5, Issue:5-6

    Topics: Acetylcholine; Aged; Aging; Animals; Brain; Choline; Clinical Trials as Topic; Dementia; Dopamine; g

1981
An update on the neurochemistry of Alzheimer disease.
    Advances in neurology, 1983, Volume: 38

    Topics: Acetylcholinesterase; Alzheimer Disease; Arecoline; Brain; Choline; Choline O-Acetyltransferase; Cho

1983
Experimental pharmacology of Alzheimer disease.
    Advances in neurology, 1983, Volume: 38

    Topics: Acetylcholine; Adult; Aged; Alzheimer Disease; Dementia; Dopamine; gamma-Aminobutyric Acid; Humans;

1983
Neurotransmitter specific alterations in dementing disorders: insights from animal models.
    Journal of psychiatric research, 1984, Volume: 18, Issue:4

    Topics: Alzheimer Disease; Animals; Brain; Cats; Cerebral Cortex; Cholinergic Fibers; Dementia; Disease Mode

1984
The pathophysiology of agitation.
    The Journal of clinical psychiatry, 2000, Volume: 61 Suppl 14

    Topics: Aggression; Behavioral Symptoms; Bipolar Disorder; Dementia; Dopamine; gamma-Aminobutyric Acid; Huma

2000
[Abnormal neurotransmission in neurological diseases (author's transl)].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1979, Volume: 24, Issue:2

    Topics: Acetylcholine; Animals; Antiparkinson Agents; Corpus Striatum; Dementia; Dopamine; Female; gamma-Ami

1979
Dementia. A brief and selective review.
    Archives of neurology, 1976, Volume: 33, Issue:1

    Topics: Alzheimer Disease; Basal Ganglia; Brain; Brain Chemistry; Caudate Nucleus; Creutzfeldt-Jakob Syndrom

1976
Biochemical approaches to dementia.
    Contemporary neurology series, 1977, Volume: 15

    Topics: Adult; Aged; Alzheimer Disease; Animals; Brain; Cerebrovascular Circulation; Dementia; gamma-Aminobu

1977
Neurotransmitters in the cerebral cortex.
    Journal of neurosurgery, 1986, Volume: 65, Issue:2

    Topics: Acetylcholine; Alzheimer Disease; Animals; Cerebral Cortex; Cerebrovascular Disorders; Dementia; Dop

1986
Petit mal epilepsy: a review and integration of recent information.
    Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society, 1986, Volume: 3, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Brain; Cognition; Dementia; Electroencephalogra

1986
[Pathophysiology of dementia].
    No to shinkei = Brain and nerve, 1985, Volume: 37, Issue:10

    Topics: Acetylcholine; Aged; Aging; Alzheimer Disease; Brain; Brain Chemistry; Dementia; Dopamine; gamma-Ami

1985

Trials

5 trials available for gamma-aminobutyric acid and Amentia

ArticleYear
The response of agitated behavior to pain management in persons with dementia.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2014, Volume: 22, Issue:7

    Topics: Acetaminophen; Aged, 80 and over; Analgesics; Buprenorphine; Delayed-Action Preparations; Dementia;

2014
Impact of a stepwise protocol for treating pain on pain intensity in nursing home patients with dementia: a cluster randomized trial.
    European journal of pain (London, England), 2014, Volume: 18, Issue:10

    Topics: Acetaminophen; Activities of Daily Living; Aged; Aged, 80 and over; Analgesics; Buprenorphine; Clini

2014
Gabapentin for the treatment of behavioural alterations in dementia: preliminary 15-month investigation.
    Drugs & aging, 2003, Volume: 20, Issue:14

    Topics: Acetates; Aged; Amines; Anti-Anxiety Agents; Comorbidity; Cyclohexanecarboxylic Acids; Dementia; Fem

2003
Neurotransmitter systems in aging and senile dementia.
    Progress in neuro-psychopharmacology, 1981, Volume: 5, Issue:5-6

    Topics: Acetylcholine; Aged; Aging; Animals; Brain; Choline; Clinical Trials as Topic; Dementia; Dopamine; g

1981
Effectiveness of gabapentin for the treatment of behavioral disorders in dementia.
    Journal of clinical psychopharmacology, 2000, Volume: 20, Issue:1

    Topics: Acetates; Aged; Aged, 80 and over; Amines; Anti-Anxiety Agents; Behavioral Symptoms; Cyclohexanecarb

2000

Other Studies

46 other studies available for gamma-aminobutyric acid and Amentia

ArticleYear
Metabolism and Memory: Obesity, Diabetes, and Dementia.
    Biological psychiatry, 2017, 12-01, Volume: 82, Issue:11

    Topics: Dementia; gamma-Aminobutyric Acid; Humans; Islet Amyloid Polypeptide; Memory; Obesity

2017
The science of tea's mood-altering magic.
    Nature, 2019, Volume: 566, Issue:7742

    Topics: Adenosine; Affect; Alpha Rhythm; Animals; Antioxidants; Behavior; Beta Rhythm; Blood-Brain Barrier;

2019
A high-quality RCT documents that elderly with dementia, the most neglected pain patients, have effective and safe pain relief from paracetamol alone or with buprenorphine patch.
    European journal of pain (London, England), 2014, Volume: 18, Issue:10

    Topics: Acetaminophen; Analgesics; Buprenorphine; Clinical Protocols; Dementia; Female; gamma-Aminobutyric A

2014
Prognostic prediction in patients with hip fracture: risk factors predicting difficulties with discharge to own home.
    Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology, 2011, Volume: 12, Issue:2

    Topics: Age Distribution; Aged; Aged, 80 and over; Comorbidity; Dementia; Disability Evaluation; Female; Fem

2011
Decrease of GABAergic markers and arc protein expression in the frontal cortex by intraventricular 192 IgG-saporin.
    Dementia and geriatric cognitive disorders, 2011, Volume: 32, Issue:1

    Topics: Acetylcholinesterase; Animals; Antibodies, Monoclonal; Blotting, Western; Choline O-Acetyltransferas

2011
Gabapentin in the treatment of dementia-associated nocturnal agitation.
    Medical science monitor : international medical journal of experimental and clinical research, 2011, Volume: 17, Issue:12

    Topics: Aged; Amines; Anti-Anxiety Agents; Cyclohexanecarboxylic Acids; Darkness; Dementia; Female; Gabapent

2011
Glutamate metabolism is impaired in transgenic mice with tau hyperphosphorylation.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2013, Volume: 33, Issue:5

    Topics: Acetates; Animals; Astrocytes; Cerebellar Cortex; Dementia; Female; gamma-Aminobutyric Acid; Glucose

2013
[Effects of gamma-aminobutyric acid-pyridoxine in presenile and senile psychiatric disorders].
    La Semana medica, 1962, Dec-31, Volume: 121

    Topics: Amino Acids; Dementia; gamma-Aminobutyric Acid; Humans; Mental Disorders; Psychotic Disorders; Pyrid

1962
Carbamazepine encephalopathy masquerading as Creutzfeldt-Jakob disease.
    Neurology, 2005, Aug-23, Volume: 65, Issue:4

    Topics: Aged; Amines; Analgesics, Non-Narcotic; Atrophy; Basal Ganglia; Brain; Brain Damage, Chronic; Carbam

2005
Delirium as a disorder of consciousness.
    Journal of neurology, neurosurgery, and psychiatry, 2007, Volume: 78, Issue:11

    Topics: Acetylcholine; Aged; Arousal; Attention; Awareness; Brain Stem; Cerebral Cortex; Child; Consciousnes

2007
Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome.
    Neuroscience letters, 2008, Mar-05, Volume: 433, Issue:1

    Topics: Acetylcholine; Animals; Brain; Cholinesterase Inhibitors; Cognition Disorders; Dementia; Disease Mod

2008
Aging and neurotransmitter systems.
    Advances in biochemical psychopharmacology, 1980, Volume: 23

    Topics: Adult; Aged; Aging; Brain; Catecholamines; Choline O-Acetyltransferase; Dementia; gamma-Aminobutyric

1980
Neurotransmitters and CNS disease. Dementia.
    Lancet (London, England), 1982, Nov-27, Volume: 2, Issue:8309

    Topics: Acetylcholine; Aged; Alzheimer Disease; Cerebral Cortex; Choline O-Acetyltransferase; Dementia; Dopa

1982
Neurotransmitters of the cerebral cortex in senile dementia of Alzheimer type.
    Experimental brain research, 1982, Volume: Suppl 5

    Topics: Aged; Alzheimer Disease; Cerebral Cortex; Choline O-Acetyltransferase; Dementia; Enkephalin, Methion

1982
Amino acid release from biopsy samples of temporal neocortex from patients with Alzheimer's disease.
    Brain research, 1983, Mar-28, Volume: 264, Issue:1

    Topics: Acetylcholine; Alzheimer Disease; Amino Acids; Aspartic Acid; Dementia; gamma-Aminobutyric Acid; Glu

1983
Decreased CSF concentrations of homovanillic acid and gamma-aminobutyric acid in Alzheimer's disease. Age- or disease-related modifications?
    Archives of neurology, 1982, Volume: 39, Issue:11

    Topics: Age Factors; Aged; Aging; Alzheimer Disease; Brain Chemistry; Dementia; Female; gamma-Aminobutyric A

1982
Gamma-aminobutyric acid (GABA) in cerebrospinal fluid.
    Acta medica Okayama, 1983, Volume: 37, Issue:3

    Topics: Adult; Behcet Syndrome; Cerebellar Diseases; Cerebral Infarction; Dementia; Female; gamma-Aminobutyr

1983
[Huntington chorea: report of 16 cases].
    Arquivos de neuro-psiquiatria, 1983, Volume: 41, Issue:2

    Topics: Adult; Aged; Brain Diseases; Chlorpromazine; Dementia; Diagnosis, Differential; Female; gamma-Aminob

1983
Free and conjugated GABA in human cerebrospinal fluid: effect of degenerative neurologic diseases and isoniazid.
    Brain research, 1984, Jul-30, Volume: 307, Issue:1-2

    Topics: Adult; Age Factors; Aged; Cerebellar Ataxia; Dementia; Epilepsy; gamma-Aminobutyric Acid; Humans; Hu

1984
Striatal dopamine receptors in Alzheimer-type dementia.
    Neuroscience letters, 1984, Nov-23, Volume: 52, Issue:1-2

    Topics: Aged; Alzheimer Disease; Choline O-Acetyltransferase; Dementia; Female; gamma-Aminobutyric Acid; Hom

1984
Levels of gamma-aminobutyric acid in cerebrospinal fluid in various neurologic disorders.
    Archives of neurology, 1980, Volume: 37, Issue:6

    Topics: Brain Chemistry; Cerebellar Diseases; Creatine Kinase; Dementia; Diet; Encephalitis; Epilepsy; gamma

1980
Gamma-aminobutyric acid and homovanillic acid concentration in the CSF of patients with senile dementia of Alzheimer's type.
    Archives of neurology, 1984, Volume: 41, Issue:6

    Topics: Aged; Alzheimer Disease; Dementia; Female; gamma-Aminobutyric Acid; Homovanillic Acid; Humans; Middl

1984
Correlation of cortical cholinergic and GABA deficits with quantitative neuropathological findings in senile dementia.
    Brain : a journal of neurology, 1984, Volume: 107 ( Pt 2)

    Topics: Alzheimer Disease; Brain; Choline O-Acetyltransferase; Cholinergic Fibers; Dementia; gamma-Aminobuty

1984
Potential therapies in aging and senile dementias.
    Annals of the New York Academy of Sciences, 1982, Volume: 396

    Topics: Acetylcholine; Aging; Alzheimer Disease; Animals; Cerebrovascular Circulation; Dementia; gamma-Amino

1982
A post-mortem study of the cholinergic and GABA systems in senile dementia.
    Brain : a journal of neurology, 1982, Volume: 105, Issue:Pt 2

    Topics: Aged; Alzheimer Disease; Brain; Cerebral Cortex; Choline O-Acetyltransferase; Dementia; gamma-Aminob

1982
Hippocampal free amino acids in Alzheimer's disease.
    Journal of neurochemistry, 1980, Volume: 35, Issue:5

    Topics: Aged; Alzheimer Disease; Amino Acids; Arginine; Aspartic Acid; Dementia; gamma-Aminobutyric Acid; Gl

1980
Gabapentin in geriatric psychiatry patients.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1998, Volume: 43, Issue:4

    Topics: Acetates; Aged; Aged, 80 and over; Alzheimer Disease; Amines; Anticonvulsants; Bipolar Disorder; Cyc

1998
Gabapentin for disruptive behaviour in an elderly demented patient.
    Drugs & aging, 1998, Volume: 13, Issue:2

    Topics: Acetates; Aged; Aged, 80 and over; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Dementia; D

1998
A retrospective chart review of gabapentin for the treatment of aggressive and agitated behavior in patients with dementias.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2000,Summer, Volume: 8, Issue:3

    Topics: Acetates; Aged; Aged, 80 and over; Aggression; Amines; Antimanic Agents; California; Cyclohexanecarb

2000
FK960, a novel potential anti-dementia drug, enhances high K(+)-evoked release of somatostatin from rat hippocampal slices.
    Brain research, 2001, Feb-16, Volume: 892, Issue:1

    Topics: Acetylcholine; Animals; Aspartic Acid; Benzamides; Dementia; gamma-Aminobutyric Acid; Hippocampus; I

2001
Gabapentin-induced worsening of neuropsychiatric symptoms in dementia with lewy bodies: case reports.
    European neurology, 2002, Volume: 47, Issue:1

    Topics: Acetates; Aged; Amines; Cyclohexanecarboxylic Acids; Dementia; Female; Gabapentin; gamma-Aminobutyri

2002
Biochemical changes in Alzheimer's disease-senile dementia: neurotransmitters in senile dementia of the Alzheimer's type.
    Research publications - Association for Research in Nervous and Mental Disease, 1979, Volume: 57

    Topics: Acetylcholine; Acetylcholinesterase; Aged; Alzheimer Disease; Brain; Choline O-Acetyltransferase; De

1979
Letter: Extrapyramidal diseases and dementia.
    Lancet (London, England), 1975, May-24, Volume: 1, Issue:7917

    Topics: Aged; Brain; Dementia; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; Parkinson Disease

1975
Choline in Alzheimer's disease.
    Lancet (London, England), 1977, Oct-15, Volume: 2, Issue:8042

    Topics: Aged; Alzheimer Disease; Cerebral Cortex; Choline; Choline O-Acetyltransferase; Dementia; gamma-Amin

1977
Cerebrospinal fluid gamma-aminobutyric acid in neurologic disease.
    Neurology, 1976, Volume: 26, Issue:8

    Topics: Aminobutyrates; Cerebrovascular Disorders; Dementia; Epilepsy, Post-Traumatic; Epilepsy, Temporal Lo

1976
Cerebrospinal fluid gamma-aminobutyric acid variations in neurological disorders.
    Archives of neurology, 1977, Volume: 34, Issue:11

    Topics: Adolescent; Adult; Aged; Alzheimer Disease; Aminobutyrates; Child; Dementia; gamma-Aminobutyric Acid

1977
Pre- and postsynaptic neurochemical alterations in Alzheimer's disease.
    Brain research, 1978, Dec-29, Volume: 159, Issue:2

    Topics: Aged; Alzheimer Disease; Caudate Nucleus; Choline O-Acetyltransferase; Dementia; Frontal Lobe; gamma

1978
Biochemical aspects of the aging brain.
    Age and ageing, 1978, Volume: Suppl

    Topics: Acetylcholine; Aging; Alzheimer Disease; Brain; Cell Count; Dementia; Energy Metabolism; gamma-Amino

1978
Glutamate and GABA levels in CSF from patients affected by dementia and olivo-ponto-cerebellar atrophy.
    Acta neurologica Scandinavica, 1992, Volume: 85, Issue:6

    Topics: Age Factors; Aged; Aged, 80 and over; Dementia; Female; gamma-Aminobutyric Acid; Glutamates; Glutami

1992
Dementia in Huntington's disease is associated with neurochemical deficits in the caudate nucleus, not the cerebral cortex.
    Neuroscience letters, 1990, May-18, Volume: 113, Issue:1

    Topics: Adult; Aged; Caudate Nucleus; Cerebral Cortex; Choline O-Acetyltransferase; Dementia; Female; gamma-

1990
Progressive supranuclear palsy: relationship between extrapyramidal disturbances, dementia, and brain neurotransmitter markers.
    Annals of neurology, 1985, Volume: 18, Issue:5

    Topics: Aged; Aspartic Acid; Basal Ganglia Diseases; Brain; Bulbar Palsy, Progressive; Choline O-Acetyltrans

1985
Studies on neurotransmitter markers of the basal ganglia in Pick's disease, with special reference to dopamine reduction.
    Journal of the neurological sciences, 1988, Volume: 83, Issue:1

    Topics: Adult; Basal Ganglia; Brain; Choline O-Acetyltransferase; Dementia; Dopamine; Female; gamma-Aminobut

1988
CSF GABA in caregiver spouses of Alzheimer patients.
    The American journal of psychiatry, 1989, Volume: 146, Issue:6

    Topics: Alzheimer Disease; Chromatography, High Pressure Liquid; Dementia; Female; gamma-Aminobutyric Acid;

1989
Effect of the 'antidementia drug' pantoyl-GABA on high affinity transport of choline and on the contents of choline and acetylcholine in rat brain.
    British journal of pharmacology, 1988, Volume: 95, Issue:4

    Topics: Acetylcholine; Animals; Biological Transport, Active; Brain; Choline; Dementia; gamma-Aminobutyric A

1988
[Drug therapy of Alzheimer's disease. General concepts on nootropic drugs].
    Nihon rinsho. Japanese journal of clinical medicine, 1988, Volume: 46, Issue:7

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amantadine; Aminoacridines; Dementia; gamma-Aminobutyric

1988
Reye-like syndrome following treatment with the pantothenic acid antagonist, calcium hopantenate.
    Journal of neurology, neurosurgery, and psychiatry, 1988, Volume: 51, Issue:4

    Topics: Aged; Biopsy; Dementia; Female; gamma-Aminobutyric Acid; Humans; Liver; Microscopy, Electron; Pantot

1988