gamma-aminobutyric acid has been researched along with Altered Level of Consciousness in 8 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Carpronium chloride has a chemical structure similar to that of acetylcholine; therefore, it exhibits both cholinergic and local vasodilatory activities." | 1.62 | Cholinergic crisis caused by ingesting topical carpronium chloride solution: A case report. ( Amagasa, S; Endo, T; Kashiura, M; Kubota, Y; Moriya, T, 2021) |
| " The adverse effects of gabapentin seem to vary from person to person and should be viewed with a high degree of suspicion, especially in patients taking this drug at the beginning." | 1.35 | Gabapentin toxicity: an important cause of altered consciousness in patients with uraemia. ( Chen, CC; Chong, CF; Hung, TY; Seow, VK; Wang, TL, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Endo, T | 1 |
| Amagasa, S | 1 |
| Kashiura, M | 1 |
| Kubota, Y | 1 |
| Moriya, T | 1 |
| Ciurleo, R | 1 |
| Bramanti, P | 1 |
| Calabrò, RS | 1 |
| Sullivan, RW | 1 |
| Ryzewski, M | 1 |
| Holland, MG | 1 |
| Marraffa, JM | 1 |
| Shimizu, T | 1 |
| Yoshida, T | 1 |
| Kitamura, K | 1 |
| Hamada, O | 1 |
| Bhat, R | 1 |
| Rockwood, K | 1 |
| Hung, TY | 1 |
| Seow, VK | 1 |
| Chong, CF | 1 |
| Wang, TL | 1 |
| Chen, CC | 1 |
| Lekomtsev, VT | 1 |
| Watanabe, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
1 review available for gamma-aminobutyric acid and Altered Level of Consciousness
| Article | Year |
|---|---|
Pharmacotherapy for disorders of consciousness: are 'awakening' drugs really a possibility?
Topics: Antidepressive Agents; Consciousness; Consciousness Disorders; Dopamine Agents; Drug Design; gamma-A | 2013 |
7 other studies available for gamma-aminobutyric acid and Altered Level of Consciousness
| Article | Year |
|---|---|
Cholinergic crisis caused by ingesting topical carpronium chloride solution: A case report.
Topics: Aged, 80 and over; Cholinesterase Inhibitors; Consciousness Disorders; Eating; Female; Flushing; gam | 2021 |
Compounded ointment results in severe toxicity in a pediatric patient.
Topics: Administration, Cutaneous; Amines; Analgesics; Body Surface Area; Bradycardia; Clonidine; Combined M | 2013 |
Disturbance of consciousness and involuntary movements caused by pregabalin.
Topics: Aged, 80 and over; Analgesics; Consciousness Disorders; Diazepam; GABA Modulators; gamma-Aminobutyri | 2012 |
Delirium as a disorder of consciousness.
Topics: Acetylcholine; Aged; Arousal; Attention; Awareness; Brain Stem; Cerebral Cortex; Child; Consciousnes | 2007 |
Gabapentin toxicity: an important cause of altered consciousness in patients with uraemia.
Topics: Amines; Anticonvulsants; Consciousness Disorders; Cyclohexanecarboxylic Acids; Diagnosis, Differenti | 2008 |
[Nootropic agents in the complex treatment of patients with traumatic epilepsy].
Topics: Adult; Brain Injuries; Consciousness Disorders; Drug Therapy, Combination; Epilepsy, Post-Traumatic; | 1990 |
[Consciousness disorders in the aged due to therapeutic drugs].
Topics: Aged; Anemia; Cognition Disorders; Consciousness Disorders; Drug Interactions; Flunarizine; gamma-Am | 1990 |