gamma-aminobutyric acid has been researched along with Allergic Encephalomyelitis in 24 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Transcriptomic and proteomic analyses of multiple sclerosis (MS) lesions indicate alterations in the gamma-aminobutyric acid (GABA) inhibitory system, suggesting its involvement in the disease process." | 3.79 | Systemic treatment with the inhibitory neurotransmitter γ-aminobutyric acid aggravates experimental autoimmune encephalomyelitis by affecting proinflammatory immune responses. ( Carmans, S; Hellings, N; Hendriks, JJ; Rigo, JM; Slaets, H; Stinissen, P; Thewissen, K, 2013) |
| "Although mouse models of experimental autoimmune encephalomyelitis (EAE) have provided insight on the pathobiology of MS-induced neuropathic pain, concurrent severe motor impairments confound quantitative assessment of pain behaviors over the disease course." | 1.40 | Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods. ( Khan, N; Smith, MT; Woodruff, TM, 2014) |
| "Mechanical allodynia was fully developed by 28-30days post-immunization (p." | 1.40 | Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods. ( Khan, N; Smith, MT; Woodruff, TM, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (12.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (8.33) | 29.6817 |
| 2010's | 14 (58.33) | 24.3611 |
| 2020's | 5 (20.83) | 2.80 |
| Authors | Studies |
|---|---|
| Kang, S | 1 |
| Liu, L | 1 |
| Wang, T | 1 |
| Cannon, M | 1 |
| Lin, P | 1 |
| Fan, TW | 1 |
| Scott, DA | 1 |
| Wu, HJ | 1 |
| Lane, AN | 1 |
| Wang, R | 1 |
| Stamoula, Е | 1 |
| Ainatzoglou, A | 1 |
| Dardalas, I | 1 |
| Vavilis, T | 1 |
| Stamatellos, VP | 1 |
| Siafis, S | 1 |
| Psathas, T | 1 |
| Boskou, I | 1 |
| Papazisis, G | 1 |
| Dąbrowska-Bouta, B | 1 |
| Strużyńska, L | 1 |
| Sidoryk-Węgrzynowicz, M | 1 |
| Sulkowski, G | 1 |
| Marchese, E | 1 |
| Valentini, M | 1 |
| Di Sante, G | 1 |
| Cesari, E | 1 |
| Adinolfi, A | 1 |
| Corvino, V | 1 |
| Ria, F | 1 |
| Sette, C | 1 |
| Geloso, MC | 1 |
| Tian, J | 1 |
| Song, M | 1 |
| Kaufman, DL | 1 |
| Benson, CA | 1 |
| Wong, G | 2 |
| Tenorio, G | 2 |
| Baker, GB | 3 |
| Kerr, BJ | 2 |
| Mori, F | 1 |
| Nisticò, R | 1 |
| Mandolesi, G | 4 |
| Piccinin, S | 1 |
| Mango, D | 1 |
| Kusayanagi, H | 1 |
| Berretta, N | 1 |
| Bergami, A | 1 |
| Gentile, A | 3 |
| Musella, A | 4 |
| Nicoletti, CG | 1 |
| Nicoletti, F | 1 |
| Buttari, F | 1 |
| Mercuri, NB | 1 |
| Martino, G | 2 |
| Furlan, R | 2 |
| Centonze, D | 4 |
| Kan, QC | 1 |
| Zhang, S | 1 |
| Xu, YM | 1 |
| Zhang, GX | 1 |
| Zhu, L | 1 |
| Sepman, H | 1 |
| Fresegna, D | 1 |
| Haji, N | 1 |
| Conrad, A | 1 |
| Lutz, B | 1 |
| Maccarrone, M | 1 |
| Paul, AM | 1 |
| Branton, WG | 1 |
| Walsh, JG | 1 |
| Polyak, MJ | 1 |
| Lu, JQ | 1 |
| Power, C | 1 |
| Khan, N | 1 |
| Woodruff, TM | 1 |
| Smith, MT | 1 |
| Silva, GA | 1 |
| Pradella, F | 1 |
| Moraes, A | 1 |
| Farias, A | 1 |
| dos Santos, LM | 1 |
| de Oliveira, AL | 1 |
| Bonfiglio, T | 1 |
| Olivero, G | 1 |
| Merega, E | 1 |
| Di Prisco, S | 1 |
| Padolecchia, C | 1 |
| Grilli, M | 1 |
| Milanese, M | 1 |
| Di Cesare Mannelli, L | 1 |
| Ghelardini, C | 1 |
| Bonanno, G | 1 |
| Marchi, M | 1 |
| Pittaluga, A | 1 |
| Bhat, R | 1 |
| Axtell, R | 1 |
| Mitra, A | 1 |
| Miranda, M | 1 |
| Lock, C | 1 |
| Tsien, RW | 1 |
| Steinman, L | 1 |
| Rossi, S | 1 |
| Muzio, L | 1 |
| De Chiara, V | 1 |
| Grasselli, G | 1 |
| Musumeci, G | 1 |
| De Ceglia, R | 1 |
| Maida, S | 1 |
| Biffi, E | 1 |
| Pedrocchi, A | 1 |
| Menegon, A | 1 |
| Bernardi, G | 1 |
| Cid, MP | 1 |
| Vilcaes, AA | 1 |
| Rupil, LL | 1 |
| Salvatierra, NA | 1 |
| Roth, GA | 1 |
| Musgrave, T | 1 |
| Benson, C | 1 |
| Browne, I | 1 |
| Rauw, G | 1 |
| Carmans, S | 1 |
| Hendriks, JJ | 1 |
| Slaets, H | 1 |
| Thewissen, K | 1 |
| Stinissen, P | 1 |
| Rigo, JM | 1 |
| Hellings, N | 1 |
| de Lago, E | 1 |
| Fernández-Ruiz, J | 1 |
| Ortega-Gutiérrez, S | 1 |
| Cabranes, A | 1 |
| Pryce, G | 1 |
| Baker, D | 1 |
| López-Rodríguez, M | 1 |
| Ramos, JA | 1 |
| Vignes, JR | 1 |
| Deloire, MS | 1 |
| Petry, KG | 1 |
| Nagy, F | 1 |
| Hamberger, A | 1 |
| Babitch, JA | 1 |
| Blomstrand, C | 1 |
| Hansson, HA | 1 |
| Sellström, A | 1 |
| Gottesfeld, Z | 1 |
| Teitelbaum, D | 1 |
| Webb, C | 1 |
| Arnon, R | 1 |
| Savoldi, F | 1 |
| Ceroni, M | 1 |
| Fussi, F | 1 |
| Curti, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Role of the Gut Microbiome as Determinant of Depression in Multiple Sclerosis Subjects[NCT05808101] | 120 participants (Anticipated) | Observational | 2022-01-27 | Recruiting | |||
| Effect of Vigabatrin in Refractory Autoimmune Encephalitis Patients - A Pilot Study[NCT03003143] | 0 participants (Actual) | Interventional | 2016-11-30 | Withdrawn | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for gamma-aminobutyric acid and Allergic Encephalomyelitis
| Article | Year |
|---|---|
Effects of GABAergic Agents on Multiple Sclerosis. A Narrative Review of
Topics: Animals; Central Nervous System; Encephalomyelitis, Autoimmune, Experimental; GABA Agonists; gamma-A | 2023 |
IL-1β dependent cerebellar synaptopathy in a mouse mode of multiple sclerosis.
Topics: Animals; Cerebellum; Encephalomyelitis, Autoimmune, Experimental; gamma-Aminobutyric Acid; Glutamic | 2015 |
22 other studies available for gamma-aminobutyric acid and Allergic Encephalomyelitis
| Article | Year |
|---|---|
GAB functions as a bioenergetic and signalling gatekeeper to control T cell inflammation.
Topics: 4-Aminobutyrate Transaminase; Aminobutyrates; Animals; Anti-Inflammatory Agents; Carbon; Encephalomy | 2022 |
Memantine Improves the Disturbed Glutamine and γ-Amino Butyric Acid Homeostasis in the Brain of Rats Subjected to Experimental Autoimmune Encephalomyelitis.
Topics: Amino Acids; Animals; Antifibrinolytic Agents; Brain; Encephalomyelitis, Autoimmune, Experimental; g | 2023 |
Alternative splicing of neurexins 1-3 is modulated by neuroinflammation in the prefrontal cortex of a murine model of multiple sclerosis.
Topics: Alternative Splicing; Animals; Calcium-Binding Proteins; Cognitive Dysfunction; Encephalitis; Enceph | 2021 |
Homotaurine limits the spreading of T cell autoreactivity within the CNS and ameliorates disease in a model of multiple sclerosis.
Topics: Animals; Antigen Presentation; Antigen-Presenting Cells; Cell Proliferation; Central Nervous System; | 2021 |
The MAO inhibitor phenelzine can improve functional outcomes in mice with established clinical signs in experimental autoimmune encephalomyelitis (EAE).
Topics: Analysis of Variance; Animals; CD4 Antigens; Central Nervous System; Chromatography, High Pressure L | 2013 |
Interleukin-1β promotes long-term potentiation in patients with multiple sclerosis.
Topics: Adolescent; Adult; Animals; Encephalomyelitis, Autoimmune, Experimental; Female; gamma-Aminobutyric | 2014 |
Matrine regulates glutamate-related excitotoxic factors in experimental autoimmune encephalomyelitis.
Topics: Alkaloids; Animals; Cerebral Cortex; Encephalomyelitis, Autoimmune, Experimental; Excitatory Amino A | 2014 |
Pre- and postsynaptic type-1 cannabinoid receptors control the alterations of glutamate transmission in experimental autoimmune encephalomyelitis.
Topics: Animals; Corpus Striatum; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Excitato | 2014 |
GABA transport and neuroinflammation are coupled in multiple sclerosis: regulation of the GABA transporter-2 by ganaxolone.
Topics: Animals; Astrocytes; Cells, Cultured; Encephalomyelitis, Autoimmune, Experimental; Female; Frontal L | 2014 |
Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods.
Topics: Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclohexanecarboxyli | 2014 |
Impact of pregabalin treatment on synaptic plasticity and glial reactivity during the course of experimental autoimmune encephalomyelitis.
Topics: Animals; Calcium-Binding Proteins; Cytokines; Disease Progression; Encephalomyelitis, Autoimmune, Ex | 2014 |
Prophylactic versus Therapeutic Fingolimod: Restoration of Presynaptic Defects in Mice Suffering from Experimental Autoimmune Encephalomyelitis.
Topics: Administration, Oral; Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Encephalomyelitis, | 2017 |
Inhibitory role for GABA in autoimmune inflammation.
Topics: 4-Aminobutyrate Transaminase; Animals; Antigen-Presenting Cells; Blotting, Western; Cells, Cultured; | 2010 |
Impaired striatal GABA transmission in experimental autoimmune encephalomyelitis.
Topics: Animals; Blotting, Western; Cells, Cultured; Corpus Striatum; Cytokines; Encephalomyelitis, Autoimmu | 2011 |
Participation of the GABAergic system on the glutamate release of frontal cortex synaptosomes from Wistar rats with experimental autoimmune encephalomyelitis.
Topics: 4-Aminopyridine; Animals; Calcium; Encephalomyelitis, Autoimmune, Experimental; Flunitrazepam; Front | 2011 |
The MAO inhibitor phenelzine improves functional outcomes in mice with experimental autoimmune encephalomyelitis (EAE).
Topics: Affect; Animals; Anterior Horn Cells; Brain Chemistry; Chromatography, High Pressure Liquid; Disease | 2011 |
Systemic treatment with the inhibitory neurotransmitter γ-aminobutyric acid aggravates experimental autoimmune encephalomyelitis by affecting proinflammatory immune responses.
Topics: Animals; Encephalomyelitis, Autoimmune, Experimental; Female; GABA Agents; gamma-Aminobutyric Acid; | 2013 |
UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Arachidonic Acids; Brain Chemistry; D | 2006 |
Characterization and restoration of altered inhibitory and excitatory control of micturition reflex in experimental autoimmune encephalomyelitis in rats.
Topics: Animals; Baclofen; Bicuculline; Cauda Equina; Efferent Pathways; Electric Stimulation; Encephalomyel | 2007 |
Evidence for differential function of neuronal and glial cells in protein metabolism and amino acid transport.
Topics: Amino Acids; Animals; Biological Transport, Active; Brain; Cell Fractionation; Cell Separation; Ence | 1975 |
Changes in the GABA system in experimental allergic encephalomyelitis-induced paralysis.
Topics: Aminobutyrates; Animals; Cattle; Choline O-Acetyltransferase; Encephalomyelitis, Autoimmune, Experim | 1976 |
Pharmacological effects of CEGABA, a new aminoacid occurring in mammalian brain.
Topics: Animals; Brain Chemistry; Chemical Phenomena; Chemistry; Electroencephalography; Encephalomyelitis, | 1987 |