gamma-aminobutyric acid has been researched along with Alcohol Drinking in 98 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Alcohol Drinking: Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking.
| Excerpt | Relevance | Reference |
|---|---|---|
| "For this purpose, using genetically selected alcohol-preferring Marchigian Sardinian (msP) rats, we evaluated the effect of pregabalin on alcohol drinking and relapse to alcohol seeking elicited by environmental conditioning factors or stress." | 7.78 | Pregabalin reduces alcohol drinking and relapse to alcohol seeking in the rat. ( Cannella, N; Ciccocioppo, R; Cippitelli, A; de Guglielmo, G; Gerra, G; Kallupi, M; Massi, M; Somaini, L; Stopponi, S, 2012) |
| "Our results showed that treatment with pregabalin (0, 10, 30 and 60 mg/kg) given orally selectively reduced home cage alcohol drinking in msP rat." | 7.78 | Pregabalin reduces alcohol drinking and relapse to alcohol seeking in the rat. ( Cannella, N; Ciccocioppo, R; Cippitelli, A; de Guglielmo, G; Gerra, G; Kallupi, M; Massi, M; Somaini, L; Stopponi, S, 2012) |
| "Gabapentinoids were involved in 2115 (2." | 5.48 | Intentional Drug Overdose Involving Pregabalin and Gabapentin: Findings from the National Self-Harm Registry Ireland, 2007-2015. ( Arensman, E; Ashcroft, DM; Daly, C; Griffin, E; Perry, IJ; Webb, RT, 2018) |
| "This article explores the mechanisms of action and the potential responder profile of acamprosate, a compound efficacious in relapse prevention of alcoholism." | 4.84 | Acamprosate: recent findings and future research directions. ( Kiefer, F; Littleton, J; Mann, K; Spanagel, R, 2008) |
| "For this purpose, using genetically selected alcohol-preferring Marchigian Sardinian (msP) rats, we evaluated the effect of pregabalin on alcohol drinking and relapse to alcohol seeking elicited by environmental conditioning factors or stress." | 3.78 | Pregabalin reduces alcohol drinking and relapse to alcohol seeking in the rat. ( Cannella, N; Ciccocioppo, R; Cippitelli, A; de Guglielmo, G; Gerra, G; Kallupi, M; Massi, M; Somaini, L; Stopponi, S, 2012) |
| "Our results showed that treatment with pregabalin (0, 10, 30 and 60 mg/kg) given orally selectively reduced home cage alcohol drinking in msP rat." | 3.78 | Pregabalin reduces alcohol drinking and relapse to alcohol seeking in the rat. ( Cannella, N; Ciccocioppo, R; Cippitelli, A; de Guglielmo, G; Gerra, G; Kallupi, M; Massi, M; Somaini, L; Stopponi, S, 2012) |
| "Current treatments for adolescent alcohol use disorder (AUD) are mainly psychosocial and limited in their efficacy." | 3.30 | N-acetylcysteine does not alter neurometabolite levels in non-treatment seeking adolescents who use alcohol heavily: A preliminary randomized clinical trial. ( Brady, KT; Browning, BD; Ferguson, PL; Gray, KM; Green, R; Kirkland, AE; Liu, H; Maralit, AM; Meyerhoff, DJ; Miranda, R; Prisciandaro, JJ; Squeglia, LM; Tomko, RL, 2023) |
| "Post-treatment, gabapentin-treated participants had less probability of drinking during the follow-up post-treatment period (p = 0." | 2.74 | A double-blind trial of gabapentin versus lorazepam in the treatment of alcohol withdrawal. ( Anton, RF; Becker, HC; Boyle, E; Malcolm, R; Myrick, H; Randall, CL; Randall, PK, 2009) |
| "Gabapentin was well tolerated and effectively diminished the symptoms of alcohol withdrawal in our population especially at the higher target dose (1200 mg) used in this study." | 2.74 | A double-blind trial of gabapentin versus lorazepam in the treatment of alcohol withdrawal. ( Anton, RF; Becker, HC; Boyle, E; Malcolm, R; Myrick, H; Randall, CL; Randall, PK, 2009) |
| "Improved treatment of alcohol dependence is a high priority, including defining subtypes that might respond differently." | 2.74 | Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptoms. ( Anton, RF; Baros, AM; Latham, PK; Malcolm, R; Myrick, H; Randall, PK; Stewart, SH; Waid, R; Wright, TM, 2009) |
| "Gabapentin is a calcium channel GABAergic modulator that is widely used for pain." | 2.58 | Gabapentin for the treatment of alcohol use disorder. ( Mason, BJ; Quello, S; Shadan, F, 2018) |
| "Expert opinion: Alcohol use disorder represents a challenge and large, unmet medical need." | 2.58 | Gabapentin for the treatment of alcohol use disorder. ( Mason, BJ; Quello, S; Shadan, F, 2018) |
| "Problematic compounds may cause seizures either acutely or on withdrawal: Their use may reduce effectiveness of antiepileptic drugs, or may simply promote and enhance chaotic lifestyles." | 2.48 | Alcohol and drugs in epilepsy: pathophysiology, presentation, possibilities, and prevention. ( Borland, W; Leach, JP; Mohanraj, R, 2012) |
| "Alcohol dependence is considered to be divisible into two types (although the divisions between these are indistinct)." | 2.39 | Current concepts of ethanol dependence. ( Little, H; Littleton, J, 1994) |
| "We found that alcohol dependence alters the global brain immune landscape increasing IL-10 producing microglia and T-regulatory cells but decreasing local amygdala IL-10 levels." | 1.62 | IL-10 normalizes aberrant amygdala GABA transmission and reverses anxiety-like behavior and dependence-induced escalation of alcohol intake. ( Abeynaike, S; Bajo, M; Borgonetti, V; D'Ambrosio, S; Edwards, S; Nikzad, R; Pahng, A; Patel, RR; Paust, S; Roberto, M; Roberts, AJ; Wolfe, SA, 2021) |
| "Gabapentinoids were involved in 2115 (2." | 1.48 | Intentional Drug Overdose Involving Pregabalin and Gabapentin: Findings from the National Self-Harm Registry Ireland, 2007-2015. ( Arensman, E; Ashcroft, DM; Daly, C; Griffin, E; Perry, IJ; Webb, RT, 2018) |
| " In the control group, chronic administration of 3-ISOPBC did not significantly decrease any of these measures at any of the doses." | 1.46 | Effects of the benzodiazepine GABA ( Cook, JM; Holtyn, AF; Stephen, MR; Tiruveedhula, VV; Weerts, EM, 2017) |
| "Gabapentin pretreatment potentiated the interoceptive effects of both experimenter-administered and self-administered alcohol in discrimination-trained rats." | 1.43 | Gabapentin potentiates sensitivity to the interoceptive effects of alcohol and increases alcohol self-administration in rats. ( Besheer, J; Frisbee, S; Jaramillo, AA; Masciello, M; Randall, PA, 2016) |
| "Alcohol use disorder is a compulsive behavior driven by motivational systems and by a poor control of consummatory behavior." | 1.39 | Endocannabinoid/GABA interactions in the entopeduncular nucleus modulates alcohol intake in rats. ( Aguilar-Roblero, R; Caynas Rojas, S; Gómez Armas, D; Méndez-Díaz, M; Prospéro-García, O; Ruiz-Contreras, AE, 2013) |
| "We describe a patient with primary writer's cramp that was completely improved by drinking a small amount of alcohol." | 1.38 | Alcohol-responsive writer's cramp. ( An, JY; Kim, JS; Lim, SC; Yoon Kang, S, 2012) |
| "Writer's cramp is a rare movement disorder of unknown etiology, in which a cramp is elicited primarily or exclusively with writing." | 1.38 | Alcohol-responsive writer's cramp. ( An, JY; Kim, JS; Lim, SC; Yoon Kang, S, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (6.12) | 18.7374 |
| 1990's | 23 (23.47) | 18.2507 |
| 2000's | 20 (20.41) | 29.6817 |
| 2010's | 34 (34.69) | 24.3611 |
| 2020's | 15 (15.31) | 2.80 |
| Authors | Studies |
|---|---|
| Lorrai, I | 1 |
| Shankula, C | 1 |
| Gaytan, JM | 1 |
| Kawamura, T | 2 |
| Maccioni, P | 1 |
| Mugnaini, C | 1 |
| Corelli, F | 1 |
| Gessa, GL | 2 |
| Sanna, PP | 2 |
| Colombo, G | 1 |
| Moe, JS | 1 |
| Bolstad, I | 1 |
| Mørland, JG | 1 |
| Bramness, JG | 1 |
| Kreifeldt, M | 1 |
| Herman, MA | 2 |
| Sidhu, H | 1 |
| Okhuarobo, A | 1 |
| Macedo, GC | 1 |
| Shahryari, R | 1 |
| Gandhi, PJ | 1 |
| Roberto, M | 8 |
| Contet, C | 1 |
| Hamel, R | 1 |
| Demers, O | 1 |
| Boileau, C | 1 |
| Roy, ML | 1 |
| Théoret, H | 1 |
| Bernier, PM | 1 |
| Lepage, JF | 1 |
| Marinkovic, K | 1 |
| Alderson Myers, AB | 1 |
| Arienzo, D | 1 |
| Sereno, MI | 1 |
| Mason, GF | 1 |
| Huh, SY | 1 |
| Kim, SG | 2 |
| Kim, HK | 2 |
| Han, SI | 2 |
| Son, BG | 2 |
| Nutt, DJ | 2 |
| Tyacke, RJ | 1 |
| Spriggs, M | 1 |
| Jacoby, V | 1 |
| Borthwick, AD | 1 |
| Belelli, D | 1 |
| Kirkland, AE | 1 |
| Browning, BD | 1 |
| Green, R | 1 |
| Liu, H | 1 |
| Maralit, AM | 1 |
| Ferguson, PL | 1 |
| Meyerhoff, DJ | 1 |
| Prisciandaro, JJ | 2 |
| Miranda, R | 1 |
| Brady, KT | 1 |
| Tomko, RL | 1 |
| Gray, KM | 1 |
| Squeglia, LM | 1 |
| DeBaker, MC | 1 |
| Mitten, EH | 1 |
| Rose, TR | 1 |
| Marron Fernandez de Velasco, E | 1 |
| Gao, R | 1 |
| Lee, AM | 1 |
| Wickman, K | 1 |
| Chuong, V | 1 |
| Farokhnia, M | 1 |
| Khom, S | 2 |
| Pince, CL | 1 |
| Elvig, SK | 1 |
| Vlkolinsky, R | 2 |
| Marchette, RC | 1 |
| Koob, GF | 2 |
| Vendruscolo, LF | 1 |
| Leggio, L | 1 |
| Borgonetti, V | 2 |
| Cruz, B | 1 |
| Vozella, V | 1 |
| Steinman, MQ | 1 |
| Bullard, R | 1 |
| D'Ambrosio, S | 2 |
| Oleata, CS | 1 |
| Bajo, M | 4 |
| Zorrilla, EP | 1 |
| Kirson, D | 1 |
| Skorput, AG | 1 |
| Lee, SM | 1 |
| Yeh, PW | 2 |
| Yeh, HH | 2 |
| Rose, M | 1 |
| Patel, RR | 1 |
| Wolfe, SA | 1 |
| Abeynaike, S | 1 |
| Pahng, A | 1 |
| Nikzad, R | 1 |
| Edwards, S | 1 |
| Paust, S | 1 |
| Roberts, AJ | 3 |
| Marguet, F | 1 |
| Friocourt, G | 1 |
| Brosolo, M | 1 |
| Sauvestre, F | 1 |
| Marcorelles, P | 1 |
| Lesueur, C | 1 |
| Marret, S | 1 |
| Gonzalez, BJ | 1 |
| Laquerrière, A | 1 |
| Agoglia, AE | 1 |
| Zhu, M | 1 |
| Quadir, SG | 1 |
| Bluitt, MN | 1 |
| Douglass, E | 1 |
| Hanback, T | 1 |
| Tella, J | 1 |
| Ying, R | 1 |
| Hodge, CW | 2 |
| Mason, BJ | 1 |
| Quello, S | 1 |
| Shadan, F | 1 |
| Cuzon Carlson, VC | 1 |
| Grant, KA | 2 |
| Lovinger, DM | 1 |
| Daly, C | 1 |
| Griffin, E | 1 |
| Ashcroft, DM | 1 |
| Webb, RT | 1 |
| Perry, IJ | 1 |
| Arensman, E | 1 |
| Schacht, JP | 3 |
| Prescot, AP | 1 |
| Renshaw, PF | 1 |
| Brown, TR | 1 |
| Anton, RF | 6 |
| Papazisis, G | 1 |
| Garyfallos, G | 1 |
| Sardeli, C | 1 |
| Kouvelas, D | 1 |
| Valenzuela, CF | 1 |
| Puglia, MP | 1 |
| Zucca, S | 1 |
| Cruz, MT | 2 |
| Schweitzer, P | 3 |
| Irons, DE | 1 |
| Iacono, WG | 1 |
| Oetting, WS | 1 |
| Kirkpatrick, RM | 1 |
| Vrieze, SI | 1 |
| Miller, MB | 1 |
| McGue, M | 1 |
| Most, D | 1 |
| Ferguson, L | 1 |
| Blednov, Y | 1 |
| Mayfield, RD | 1 |
| Harris, RA | 3 |
| Matsushita, S | 1 |
| Higuchi, S | 1 |
| Repunte-Canonigo, V | 1 |
| Herman, M | 1 |
| Kranzler, HR | 1 |
| Sherva, R | 1 |
| Gelernter, J | 1 |
| Farrer, LA | 1 |
| Ding, ZM | 1 |
| Ingraham, CM | 1 |
| Rodd, ZA | 1 |
| McBride, WJ | 3 |
| Jung, WY | 1 |
| Lee, JS | 1 |
| Choe, S | 1 |
| Downes, MA | 1 |
| Berling, IL | 1 |
| Mostafa, A | 1 |
| Grice, J | 1 |
| Roberts, MS | 1 |
| Isbister, GK | 1 |
| Besheer, J | 1 |
| Frisbee, S | 1 |
| Randall, PA | 1 |
| Jaramillo, AA | 1 |
| Masciello, M | 1 |
| Cates-Gatto, C | 1 |
| Varodayan, FP | 1 |
| Nadav, T | 1 |
| Lasek, AW | 1 |
| Magazzini, L | 1 |
| Muthukumaraswamy, SD | 1 |
| Campbell, AE | 1 |
| Hamandi, K | 1 |
| Lingford-Hughes, A | 1 |
| Myers, JF | 1 |
| Sumner, P | 1 |
| Wilson, SJ | 1 |
| Singh, KD | 1 |
| Cheng, Y | 1 |
| Huang, CCY | 1 |
| Ma, T | 1 |
| Wei, X | 1 |
| Wang, X | 1 |
| Lu, J | 1 |
| Wang, J | 1 |
| Holtyn, AF | 1 |
| Tiruveedhula, VV | 1 |
| Stephen, MR | 1 |
| Cook, JM | 1 |
| Weerts, EM | 1 |
| Mann, K | 1 |
| Kiefer, F | 1 |
| Spanagel, R | 1 |
| Littleton, J | 2 |
| Brower, KJ | 1 |
| Myra Kim, H | 1 |
| Strobbe, S | 1 |
| Karam-Hage, MA | 1 |
| Consens, F | 1 |
| Zucker, RA | 1 |
| Siggins, GR | 2 |
| Messing, R | 1 |
| Andrikoula, M | 1 |
| Prelevic, G | 1 |
| Middleton, FA | 1 |
| Carrierfenster, K | 1 |
| Mooney, SM | 1 |
| Youngentob, SL | 1 |
| Myrick, H | 5 |
| Malcolm, R | 2 |
| Randall, PK | 5 |
| Boyle, E | 1 |
| Becker, HC | 1 |
| Randall, CL | 1 |
| Baros, AM | 3 |
| Latham, PK | 3 |
| Wright, TM | 3 |
| Stewart, SH | 1 |
| Waid, R | 1 |
| Izco, M | 1 |
| Gutierrez-Lopez, MD | 1 |
| Marchant, I | 1 |
| O'Shea, E | 1 |
| Colado, MI | 1 |
| Caputo, F | 1 |
| Bernardi, M | 1 |
| Ray, LA | 1 |
| Hutchison, KE | 1 |
| Ashenhurst, JR | 1 |
| Morrow, AL | 2 |
| Chefer, V | 1 |
| Meis, J | 1 |
| Wang, G | 1 |
| Kuzmin, A | 1 |
| Bakalkin, G | 1 |
| Shippenberg, T | 1 |
| Saba, LM | 1 |
| Bennett, B | 1 |
| Hoffman, PL | 1 |
| Barcomb, K | 1 |
| Ishii, T | 1 |
| Kechris, K | 1 |
| Tabakoff, B | 1 |
| Waid, LR | 2 |
| Steffensen, SC | 1 |
| Bradley, KD | 1 |
| Hansen, DM | 1 |
| Wilcox, JD | 1 |
| Wilcox, RS | 1 |
| Allison, DW | 1 |
| Merrill, CB | 1 |
| Edwards, JG | 1 |
| Stopponi, S | 1 |
| Somaini, L | 1 |
| Cippitelli, A | 1 |
| de Guglielmo, G | 1 |
| Kallupi, M | 1 |
| Cannella, N | 1 |
| Gerra, G | 1 |
| Massi, M | 2 |
| Ciccocioppo, R | 2 |
| Lim, SC | 1 |
| Kim, JS | 2 |
| An, JY | 1 |
| Yoon Kang, S | 1 |
| Kemppainen, H | 1 |
| Raivio, N | 1 |
| Kiianmaa, K | 2 |
| Romano-López, A | 1 |
| Méndez-Díaz, M | 2 |
| Ruiz-Contreras, AE | 2 |
| Carrisoza, R | 1 |
| Prospéro-García, O | 2 |
| Leach, JP | 1 |
| Mohanraj, R | 1 |
| Borland, W | 1 |
| Caynas Rojas, S | 1 |
| Gómez Armas, D | 1 |
| Aguilar-Roblero, R | 1 |
| Li, X | 1 |
| Henderson, S | 1 |
| Malcolm, RJ | 1 |
| Oh, SH | 1 |
| Soh, JR | 1 |
| Cha, YS | 1 |
| Wallner, M | 1 |
| Hanchar, HJ | 1 |
| Olsen, RW | 1 |
| Nie, Z | 1 |
| Madamba, SG | 1 |
| Moore, SD | 1 |
| Hess, CW | 1 |
| Saunders-Pullman, R | 1 |
| Eva, C | 1 |
| Serra, M | 2 |
| Mele, P | 1 |
| Panzica, G | 1 |
| Oberto, A | 1 |
| Ojanen, SP | 1 |
| Palmén, M | 1 |
| Hyytiä, P | 1 |
| Szumlinski, KK | 1 |
| Diab, ME | 1 |
| Friedman, R | 1 |
| Henze, LM | 1 |
| Lominac, KD | 1 |
| Bowers, MS | 1 |
| Porcu, P | 1 |
| Boyd, KN | 1 |
| Cuzon, VC | 1 |
| Yanagawa, Y | 1 |
| Obata, K | 1 |
| Claus, D | 1 |
| Kornhuber, ME | 1 |
| Ahn, YS | 1 |
| Fenner, D | 1 |
| Feller, D | 1 |
| Sieckman, G | 1 |
| Lloyd, S | 1 |
| Mitchell, M | 1 |
| Dexter, JD | 1 |
| Tumbelson, ME | 1 |
| Bylund, DB | 1 |
| Ticku, MK | 1 |
| Burch, T | 1 |
| Abbondanza, A | 1 |
| Sanna, E | 1 |
| Little, H | 1 |
| Thielen, RJ | 2 |
| Lumeng, L | 2 |
| Li, TK | 2 |
| Rassnick, S | 1 |
| D'Amico, E | 1 |
| Riley, E | 1 |
| Chappelle, AM | 1 |
| Samson, HH | 1 |
| Buck, KJ | 1 |
| Tomkins, DM | 1 |
| Sellers, EM | 1 |
| Fletcher, PJ | 1 |
| Volkow, ND | 1 |
| Wang, GJ | 1 |
| Fowler, JS | 1 |
| Logan, J | 1 |
| Hitzemann, R | 1 |
| Ding, YS | 1 |
| Pappas, N | 1 |
| Shea, C | 1 |
| Piscani, K | 1 |
| Chernet, E | 1 |
| Fadda, F | 2 |
| Rossetti, ZL | 2 |
| De Witte, P | 2 |
| Chatterjee, CR | 1 |
| Ringold, AL | 1 |
| Angeletti, S | 1 |
| Panocka, I | 1 |
| Uusi-Oukari, M | 1 |
| Mäkelä, R | 1 |
| Soini, S | 1 |
| Korpi, ER | 1 |
| Sinclair, JD | 1 |
| Wahlsten, D | 1 |
| Overstreet, DH | 1 |
| Smith, BR | 2 |
| Robidoux, J | 1 |
| Amit, Z | 2 |
| Boyle, AE | 1 |
| Biggio, G | 1 |
| Cibin, M | 1 |
| Diana, M | 1 |
| Ferrara, SD | 1 |
| Gallimberti, L | 1 |
| Mereu, GP | 1 |
| Allan, AM | 1 |
| Mayes, GG | 1 |
| Draski, LJ | 1 |
| Gewiss, M | 1 |
| Heidbreder, C | 1 |
| Opsomer, L | 1 |
| Durbin, P | 1 |
| Roy, A | 2 |
| DeJong, J | 2 |
| Lamparski, D | 1 |
| George, T | 1 |
| Linnoila, M | 2 |
| Moss, HB | 1 |
| Yao, JK | 1 |
| Burns, M | 1 |
| Maddock, J | 1 |
| Tarter, RE | 1 |
| Ferraro, T | 1 |
| Adinoff, B | 1 |
| Ravitz, B | 1 |
| Malka, R | 1 |
| Ollat, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Semaglutide Therapy for Alcohol Reduction (STAR): A Proof-of-Concept Phase II Clinical Trial[NCT06015893] | Phase 2 | 52 participants (Anticipated) | Interventional | 2024-01-03 | Recruiting | ||
| Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776] | Phase 2 | 54 participants (Actual) | Interventional | 2017-08-07 | Completed | ||
| A Double Blind Evaluation of Flumazenil and Gabapentin for the Treatment of Alcohol Withdrawal and Relapse Prevention[NCT00262639] | Phase 2/Phase 3 | 60 participants (Actual) | Interventional | 2005-12-31 | Completed | ||
| Gabapentin as an Adjunct to Naltrexone for Alcoholism[NCT00183196] | Phase 3 | 150 participants (Actual) | Interventional | 2003-01-31 | Completed | ||
| Neurocognitive and Neurobehavioral Mechanisms of Change Following Psychological[NCT03842670] | 140 participants (Anticipated) | Interventional | 2018-11-14 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 3.90 |
| Gabapentin | 3.93 |
| Placebo Oral Tablet | 3.73 |
Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 21.59 |
| Gabapentin | 21.69 |
| Placebo Oral Tablet | 22.25 |
percent days abstinent during treatment (NCT00262639)
Timeframe: Weeks 1 to 6
| Intervention | percent days (Mean) |
|---|---|
| Low CIWA Flumazenil/Gabapentin | 70.8 |
| Low CIWAar Placebo | 86.1 |
| High CIWAar Placebo | 75.9 |
| High CIWAar Flumazenil/Gabapentin | 95.9 |
percent of subjects completely abstinent during the six week medication study study (NCT00262639)
Timeframe: 6 week trial
| Intervention | percent of participants (Number) |
|---|---|
| Low CIWA Flumazenil/Gabapentin | 44 |
| Low CIWAar Placebo | 19 |
| High CIWAar Placebo | 33 |
| High CIWAar Flumazenil/Gabapentin | 71 |
Time to relapse drinking which is 5 standard drinks perday for males and 4 standard drinks per day for females. Subjects had a minimum of 4 days of abstinence prior to being entered into the protocol. (NCT00183196)
Timeframe: 16 weeks
| Intervention | days (Mean) |
|---|---|
| Naltrexone Plus Gabapentin and CBI | 69.9 |
| Naltrexone Plus Placebo and CBI | 59.6 |
| Placebo Plus Placebo Plus CBI | 57.3 |
20 reviews available for gamma-aminobutyric acid and Alcohol Drinking
| Article | Year |
|---|---|
Functional Alternatives to Alcohol.
Topics: Alcohol Drinking; Brain; Ethanol; gamma-Aminobutyric Acid | 2022 |
Gabapentin for the treatment of alcohol use disorder.
Topics: Alcohol Drinking; Alcoholism; Amines; Animals; Calcium Channel Blockers; Cyclohexanecarboxylic Acids | 2018 |
Focus on: neurotransmitter systems.
Topics: Alcohol Drinking; Animals; Biogenic Amines; Female; Fetal Alcohol Spectrum Disorders; gamma-Aminobut | 2011 |
Shared mechanisms of alcohol and other drugs.
Topics: Alcohol Drinking; Alcoholism; Analgesics, Opioid; Animals; Cannabinoids; gamma-Aminobutyric Acid; Hu | 2008 |
Genetic differences in response to alcohol.
Topics: Alcohol Dehydrogenase; Alcohol Drinking; Alcoholism; Aldehyde Dehydrogenase; Animals; Ethanol; gamma | 2014 |
Acamprosate: recent findings and future research directions.
Topics: Acamprosate; Alcohol Deterrents; Alcohol Drinking; Alcoholism; Animals; gamma-Aminobutyric Acid; Glu | 2008 |
Menopausal hot flushes revisited.
Topics: Acupuncture Therapy; Adult; Alcohol Drinking; Amines; Caffeine; Cyclohexanecarboxylic Acids; Estroge | 2009 |
Medications acting on the GABA system in the treatment of alcoholic patients.
Topics: Alcohol Drinking; Alcoholism; Animals; Diagnosis, Dual (Psychiatry); Ethanol; GABA Agents; gamma-Ami | 2010 |
Alcohol and drugs in epilepsy: pathophysiology, presentation, possibilities, and prevention.
Topics: Alcohol Drinking; Alcohol Withdrawal Seizures; Alcoholism; Amphetamine-Related Disorders; Benzodiaze | 2012 |
Movement disorders and alcohol misuse.
Topics: Adjuvants, Anesthesia; Alcohol Drinking; Brain; Comorbidity; Dystonic Disorders; Essential Tremor; E | 2006 |
Physiology and gene regulation of the brain NPY Y1 receptor.
Topics: Alcohol Drinking; Animals; Anxiety; Brain; Feeding Behavior; Female; gamma-Aminobutyric Acid; Gene E | 2006 |
Hypothalamic-pituitary-adrenal axis modulation of GABAergic neuroactive steroids influences ethanol sensitivity and drinking behavior.
Topics: Alcohol Drinking; Animals; Brain Chemistry; Central Nervous System Depressants; Discrimination, Psyc | 2006 |
Recent developments in alcoholism:neuronal ion channels.
Topics: Alcohol Drinking; Alcoholic Intoxication; Alcoholism; Animals; Brain; gamma-Aminobutyric Acid; Gluta | 1993 |
Current concepts of ethanol dependence.
Topics: Alcohol Drinking; Alcoholism; Animals; Arousal; Brain; gamma-Aminobutyric Acid; Humans; Motivation; | 1994 |
Molecular genetic analysis of the role of GABAergic systems in the behavioral and cellular actions of alcohol.
Topics: Alcohol Drinking; Alcoholism; Animals; Brain; Chromosome Mapping; gamma-Aminobutyric Acid; Humans; R | 1996 |
Chronic ethanol consumption: from neuroadaptation to neurodegeneration.
Topics: Acetylcholine; Adaptation, Physiological; Alcohol Amnestic Disorder; Alcohol Drinking; Alcohol-Relat | 1998 |
The role of neurotransmitters in alcohol dependence: animal research.
Topics: Alcohol Drinking; Alcoholism; Animals; Brain; Dopamine; Endorphins; gamma-Aminobutyric Acid; Neurotr | 1996 |
Nociceptin/orphanin FQ and drugs of abuse.
Topics: Alcohol Drinking; Analgesics, Opioid; Animals; Behavior; Brain; Dopamine; gamma-Aminobutyric Acid; G | 2000 |
Suppression of voluntary alcohol intake in rats and alcoholics by gamma-hydroxybutyric acid: a non-GABAergic mechanism.
Topics: Alcohol Drinking; Alcoholism; Animals; gamma-Aminobutyric Acid; Humans; Rats; Sodium Oxybate | 1992 |
[GABA and alcohol].
Topics: Alcohol Drinking; Alcoholism; Animals; Ethanol; gamma-Aminobutyric Acid; Humans; Nervous System; Rec | 1987 |
13 trials available for gamma-aminobutyric acid and Alcohol Drinking
| Article | Year |
|---|---|
The neurobiological markers of acute alcohol's subjective effects in humans.
Topics: Alcohol Drinking; Alcoholism; Cross-Over Studies; Ethanol; Female; gamma-Aminobutyric Acid; Humans; | 2022 |
Effect of Extract of Black Sticky Rice with Giant Embryo on Alcohol Cravings of Korean Social Drinkers: A 12-Week Randomized, Placebo-Controlled Trial.
Topics: Alcohol Drinking; Alcoholism; Craving; gamma-Aminobutyric Acid; Humans; Oryza; Plant Extracts; Repub | 2022 |
N-acetylcysteine does not alter neurometabolite levels in non-treatment seeking adolescents who use alcohol heavily: A preliminary randomized clinical trial.
Topics: Acetylcysteine; Adolescent; Alcohol Drinking; Alcoholism; Double-Blind Method; Ethanol; Female; gamm | 2023 |
Effect of GABA Extract of Black Sticky Rice with Giant Embryo on Alcohol-Related Indices After Acute Alcohol Intake in Social Drinkers.
Topics: Adult; Alcohol Drinking; Alcohol-Related Disorders; Female; gamma-Aminobutyric Acid; Humans; Male; M | 2015 |
A randomized double-blind pilot trial of gabapentin versus placebo to treat alcohol dependence and comorbid insomnia.
Topics: Adult; Alcohol Drinking; Alcoholism; Amines; Antimanic Agents; Cyclohexanecarboxylic Acids; Dose-Res | 2008 |
A double-blind trial of gabapentin versus lorazepam in the treatment of alcohol withdrawal.
Topics: Adult; Alcohol Drinking; Amines; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Doub | 2009 |
Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptoms.
Topics: Administration, Oral; Adult; Alcohol Drinking; Alcoholism; Amines; Cyclohexanecarboxylic Acids; Doub | 2009 |
Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptoms.
Topics: Administration, Oral; Adult; Alcohol Drinking; Alcoholism; Amines; Cyclohexanecarboxylic Acids; Doub | 2009 |
Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptoms.
Topics: Administration, Oral; Adult; Alcohol Drinking; Alcoholism; Amines; Cyclohexanecarboxylic Acids; Doub | 2009 |
Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptoms.
Topics: Administration, Oral; Adult; Alcohol Drinking; Alcoholism; Amines; Cyclohexanecarboxylic Acids; Doub | 2009 |
Naltrexone selectively elevates GABAergic neuroactive steroid levels in heavy drinkers with the Asp40 allele of the OPRM1 gene: a pilot investigation.
Topics: Adult; Alcohol Drinking; Alcoholism; Alleles; Amino Acid Substitution; Aspartic Acid; Double-Blind M | 2010 |
Gabapentin combined with naltrexone for the treatment of alcohol dependence.
Topics: Adult; Alcohol Drinking; Alcoholism; Amines; Cyclohexanecarboxylic Acids; Drug Administration Schedu | 2011 |
Gabapentin combined with naltrexone for the treatment of alcohol dependence.
Topics: Adult; Alcohol Drinking; Alcoholism; Amines; Cyclohexanecarboxylic Acids; Drug Administration Schedu | 2011 |
Gabapentin combined with naltrexone for the treatment of alcohol dependence.
Topics: Adult; Alcohol Drinking; Alcoholism; Amines; Cyclohexanecarboxylic Acids; Drug Administration Schedu | 2011 |
Gabapentin combined with naltrexone for the treatment of alcohol dependence.
Topics: Adult; Alcohol Drinking; Alcoholism; Amines; Cyclohexanecarboxylic Acids; Drug Administration Schedu | 2011 |
Neurocognitive performance, alcohol withdrawal, and effects of a combination of flumazenil and gabapentin in alcohol dependence.
Topics: Adult; Alcohol Drinking; Alcoholism; Amines; Cognition; Cyclohexanecarboxylic Acids; Drug Therapy, C | 2011 |
Neurocognitive performance, alcohol withdrawal, and effects of a combination of flumazenil and gabapentin in alcohol dependence.
Topics: Adult; Alcohol Drinking; Alcoholism; Amines; Cognition; Cyclohexanecarboxylic Acids; Drug Therapy, C | 2011 |
Neurocognitive performance, alcohol withdrawal, and effects of a combination of flumazenil and gabapentin in alcohol dependence.
Topics: Adult; Alcohol Drinking; Alcoholism; Amines; Cognition; Cyclohexanecarboxylic Acids; Drug Therapy, C | 2011 |
Neurocognitive performance, alcohol withdrawal, and effects of a combination of flumazenil and gabapentin in alcohol dependence.
Topics: Adult; Alcohol Drinking; Alcoholism; Amines; Cognition; Cyclohexanecarboxylic Acids; Drug Therapy, C | 2011 |
Effects of a GABA-ergic medication combination and initial alcohol withdrawal severity on cue-elicited brain activation among treatment-seeking alcoholics.
Topics: Adult; Alcohol Drinking; Alcoholism; Amines; Brain; Cues; Cyclohexanecarboxylic Acids; Drug Therapy, | 2013 |
Suppression of voluntary alcohol intake in rats and alcoholics by gamma-hydroxybutyric acid: a non-GABAergic mechanism.
Topics: Alcohol Drinking; Alcoholism; Animals; gamma-Aminobutyric Acid; Humans; Rats; Sodium Oxybate | 1992 |
Plasma GABA-like activity in response to ethanol challenge in men at high risk for alcoholism.
Topics: Adult; Alcohol Drinking; Alcoholic Intoxication; Alcoholism; Breath Tests; Ethanol; gamma-Aminobutyr | 1990 |
66 other studies available for gamma-aminobutyric acid and Alcohol Drinking
| Article | Year |
|---|---|
Reducing effect of the novel positive allosteric modulator of the GABA
Topics: Alcohol Drinking; Animals; Ethanol; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred C57BL; Rats; R | 2022 |
GABA
Topics: Alcohol Drinking; Alcoholism; Female; gamma-Aminobutyric Acid; Genotype; Humans; Linkage Disequilibr | 2022 |
Central amygdala corticotropin-releasing factor neurons promote hyponeophagia but do not control alcohol drinking in mice.
Topics: Alcohol Drinking; Alcoholism; Animals; Central Amygdaloid Nucleus; Corticotropin-Releasing Hormone; | 2022 |
Cortical GABA levels are reduced in young adult binge drinkers: Association with recent alcohol consumption and sex.
Topics: Alcohol Drinking; Binge Drinking; Blood Alcohol Content; Brain; Child, Preschool; Ethanol; Female; g | 2022 |
RGS6 negatively regulates inhibitory G protein signaling in dopamine neurons and positively regulates binge-like alcohol consumption in mice.
Topics: Alcohol Drinking; Animals; Dopamine; Dopaminergic Neurons; Female; gamma-Aminobutyric Acid; Male; Mi | 2023 |
The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission.
Topics: Alcohol Drinking; Alcoholism; Animals; Female; gamma-Aminobutyric Acid; Glucagon-Like Peptide 1; Mal | 2023 |
IL-18 Signaling in the Rat Central Amygdala Is Disrupted in a Comorbid Model of Post-Traumatic Stress and Alcohol Use Disorder.
Topics: Alcohol Drinking; Alcoholism; Animals; Central Amygdaloid Nucleus; Ethanol; Female; gamma-Aminobutyr | 2023 |
The NKCC1 antagonist bumetanide mitigates interneuronopathy associated with ethanol exposure in utero.
Topics: Alcohol Drinking; Animals; Bumetanide; Cerebral Cortex; Disease Models, Animal; Female; Fetal Alcoho | 2019 |
Gabapentin reduced drinking in patients with alcohol use disorder and alcohol withdrawal symptoms.
Topics: Alcohol Drinking; Alcoholism; Gabapentin; gamma-Aminobutyric Acid; Humans; Substance Withdrawal Synd | 2020 |
IL-10 normalizes aberrant amygdala GABA transmission and reverses anxiety-like behavior and dependence-induced escalation of alcohol intake.
Topics: Alcohol Drinking; Alcoholism; Animals; Anxiety; Central Amygdaloid Nucleus; Ethanol; gamma-Aminobuty | 2021 |
Prenatal alcohol exposure is a leading cause of interneuronopathy in humans.
Topics: Alcohol Drinking; Alcoholism; Binge Drinking; Brain; Calbindin 2; Case-Control Studies; Cell Movemen | 2020 |
Sex-specific plasticity in CRF regulation of inhibitory control in central amygdala CRF1 neurons after chronic voluntary alcohol drinking.
Topics: Alcohol Drinking; Animals; Central Amygdaloid Nucleus; Corticotropin-Releasing Hormone; Ethanol; Fem | 2022 |
Synaptic adaptations to chronic ethanol intake in male rhesus monkey dorsal striatum depend on age of drinking onset.
Topics: Adaptation, Physiological; Age Factors; Age of Onset; Alcohol Drinking; Animals; Central Nervous Sys | 2018 |
Intentional Drug Overdose Involving Pregabalin and Gabapentin: Findings from the National Self-Harm Registry Ireland, 2007-2015.
Topics: Adult; Alcohol Drinking; Amines; Cyclohexanecarboxylic Acids; Drug Overdose; Emergency Service, Hosp | 2018 |
Brain Glutamate, GABA, and Glutamine Levels and Associations with Recent Drinking in Treatment-Naïve Individuals with Alcohol Use Disorder Versus Light Drinkers.
Topics: Adult; Alcohol Drinking; Alcoholism; Aspartic Acid; Case-Control Studies; Female; gamma-Aminobutyric | 2019 |
Pregabalin abuse after past substance-seeking behavior.
Topics: Alcohol Drinking; Anti-Anxiety Agents; Anxiety Disorders; Behavior, Addictive; Drug-Seeking Behavior | 2013 |
Gamma-aminobutyric acid system genes--no evidence for a role in alcohol use and abuse in a community-based sample.
Topics: Adolescent; Adult; Alcohol Drinking; Alcoholism; Female; Follow-Up Studies; gamma-Aminobutyric Acid; | 2014 |
The synaptoneurosome transcriptome: a model for profiling the emolecular effects of alcohol.
Topics: Alcohol Drinking; Alcoholism; Amygdala; Animals; Ethanol; Female; gamma-Aminobutyric Acid; Gene Expr | 2015 |
Nf1 regulates alcohol dependence-associated excessive drinking and gamma-aminobutyric acid release in the central amygdala in mice and is associated with alcohol dependence in humans.
Topics: Alcohol Drinking; Alcoholism; Animals; Central Amygdaloid Nucleus; Ethanol; gamma-Aminobutyric Acid; | 2015 |
The reinforcing effects of ethanol within the nucleus accumbens shell involve activation of local GABA and serotonin receptors.
Topics: Alcohol Drinking; Animals; Benzamides; Bicuculline; Bridged Bicyclo Compounds, Heterocyclic; Ethanol | 2015 |
Acute behavioural disturbance associated with phenibut purchased via an internet supplier.
Topics: Adult; Alcohol Drinking; Delirium; Dronabinol; Emergency Service, Hospital; Female; gamma-Aminobutyr | 2015 |
Gabapentin potentiates sensitivity to the interoceptive effects of alcohol and increases alcohol self-administration in rats.
Topics: Alcohol Drinking; Alcohols; Amines; Analgesics; Analysis of Variance; Animals; Central Nervous Syste | 2016 |
Dependence-induced ethanol drinking and GABA neurotransmission are altered in Alk deficient mice.
Topics: Alcohol Drinking; Alcoholism; Anaplastic Lymphoma Kinase; Animals; Central Amygdaloid Nucleus; Centr | 2016 |
Significant reductions in human visual gamma frequency by the gaba reuptake inhibitor tiagabine revealed by robust peak frequency estimation.
Topics: Alcohol Drinking; Brain; Central Nervous System Depressants; Computer Simulation; Cross-Over Studies | 2016 |
Distinct Synaptic Strengthening of the Striatal Direct and Indirect Pathways Drives Alcohol Consumption.
Topics: Alcohol Drinking; Animals; Corpus Striatum; Designer Drugs; GABAergic Neurons; gamma-Aminobutyric Ac | 2017 |
Effects of the benzodiazepine GABA
Topics: Alcohol Drinking; Animals; Benzodiazepines; Drug-Seeking Behavior; Ethanol; GABA-A Receptor Antagoni | 2017 |
Protein kinase C epsilon mediation of CRF- and ethanol-induced GABA release in central amygdala.
Topics: Alcohol Drinking; Amygdala; Animals; Anxiety; Corticotropin-Releasing Hormone; Ethanol; gamma-Aminob | 2008 |
Gestational ethanol exposure alters the behavioral response to ethanol odor and the expression of neurotransmission genes in the olfactory bulb of adolescent rats.
Topics: Alcohol Drinking; Animals; Behavior, Animal; Ethanol; Female; Fetus; gamma-Aminobutyric Acid; Gene E | 2009 |
Administration of neurotoxic doses of MDMA reduces sensitivity to ethanol and increases GAT-1 immunoreactivity in mice striatum.
Topics: Alcohol Drinking; Animals; Corpus Striatum; Dopamine; Drug Tolerance; Ethanol; GABA Plasma Membrane | 2010 |
Repeated exposure to moderate doses of ethanol augments hippocampal glutamate neurotransmission by increasing release.
Topics: Alcohol Drinking; Animals; Brain Mapping; CA3 Region, Hippocampal; Ethanol; Extracellular Fluid; gam | 2011 |
A systems genetic analysis of alcohol drinking by mice, rats and men: influence of brain GABAergic transmission.
Topics: Alcohol Drinking; Animals; Brain; Central Nervous System Depressants; Ethanol; gamma-Aminobutyric Ac | 2011 |
The role of connexin-36 gap junctions in alcohol intoxication and consumption.
Topics: Action Potentials; Alcohol Drinking; Alcoholic Intoxication; Animals; Central Nervous System Depress | 2011 |
Pregabalin reduces alcohol drinking and relapse to alcohol seeking in the rat.
Topics: Alcohol Drinking; Animals; Anticonvulsants; Conditioning, Operant; Dose-Response Relationship, Drug; | 2012 |
Alcohol-responsive writer's cramp.
Topics: Adult; Alcohol Drinking; Brain; Dystonic Disorders; Electromyography; Ethanol; Female; gamma-Aminobu | 2012 |
Role for ventral pallidal GABAergic mechanisms in the regulation of ethanol self-administration.
Topics: Alcohol Drinking; Animals; Dose-Response Relationship, Drug; Ethanol; GABA Agonists; GABA Antagonist | 2012 |
Maternal separation and proclivity for ethanol intake: a potential role of the endocannabinoid system in rats.
Topics: Age Factors; Alcohol Drinking; Analysis of Variance; Animals; Animals, Newborn; Brain; Central Nervo | 2012 |
Endocannabinoid/GABA interactions in the entopeduncular nucleus modulates alcohol intake in rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Endocannabinoids; Entopeduncular Nucleus; GABA Agonists; GABA | 2013 |
GABA systems, benzodiazepines, and substance dependence.
Topics: Alcohol Drinking; Alcohol-Related Disorders; Benzodiazepines; gamma-Aminobutyric Acid; Humans; Hypno | 2003 |
Germinated brown rice extract shows a nutraceutical effect in the recovery of chronic alcohol-related symptoms.
Topics: Alcohol Drinking; Amino Acids; Animals; Cholesterol, HDL; Disease Models, Animal; gamma-Aminobutyric | 2003 |
Ethanol enhances alpha 4 beta 3 delta and alpha 6 beta 3 delta gamma-aminobutyric acid type A receptors at low concentrations known to affect humans.
Topics: Alcohol Drinking; Animals; Chlorides; DNA, Complementary; Dose-Response Relationship, Drug; Electric | 2003 |
Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors.
Topics: Alcohol Drinking; Amygdala; Animals; Corticotropin-Releasing Hormone; Dose-Response Relationship, Dr | 2004 |
Extracellular glutamate and GABA in the ventral tegmental area of alcohol-preferring AA and alcohol-avoiding ANA rats treated repeatedly with morphine.
Topics: Alcohol Drinking; Analgesics, Opioid; Animals; Extracellular Space; gamma-Aminobutyric Acid; Glutami | 2007 |
Accumbens neurochemical adaptations produced by binge-like alcohol consumption.
Topics: Alcohol Drinking; Alcoholism; Animals; Central Nervous System Depressants; Disease Models, Animal; D | 2007 |
Ethanol consumption during early pregnancy alters the disposition of tangentially migrating GABAergic interneurons in the fetal cortex.
Topics: Alcohol Drinking; Animals; Cell Movement; Cerebral Cortex; Coculture Techniques; Ethanol; Female; Fe | 2008 |
[Effect of ethanol on the neurotransmitters glutamate and GABA].
Topics: Alcohol Drinking; Animals; Brain; Corpus Striatum; Frontal Lobe; gamma-Aminobutyric Acid; Glutamates | 1982 |
Neurochemical effects of long-term ingestion of ethanol by Sinclair (S-1) swine.
Topics: Alcohol Drinking; Animals; Brain; Caudate Nucleus; Cerebellum; Cerebral Cortex; Cholesterol; Female; | 1983 |
Glutamine-induced alterations in the content of brain amino acid neurotransmitters in rats with different alcohol motivation.
Topics: Alcohol Drinking; Amino Acids; Animals; Brain; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; G | 1984 |
Alterations in gamma-aminobutyric acid receptor sensitivity following acute and chronic ethanol treatments.
Topics: Alcohol Drinking; Animals; Brain; Ethanol; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred C57BL; | 1980 |
Effect of lithium chloride on cerebral GABA levels in rats after single or repeated doses of ethanol.
Topics: Alcohol Drinking; Animals; Brain; Dose-Response Relationship, Drug; Ethanol; gamma-Aminobutyric Acid | 1980 |
Housing conditions alter GABAA receptor of alcohol-preferring and -nonpreferring rats.
Topics: Alcohol Drinking; Animals; Chlorine; Flunitrazepam; gamma-Aminobutyric Acid; Male; Radioisotopes; Ra | 1993 |
GABA antagonist and benzodiazepine partial inverse agonist reduce motivated responding for ethanol.
Topics: Alcohol Drinking; Animals; Appetitive Behavior; Arousal; Azides; Benzodiazepines; Brain; Chlordiazep | 1993 |
GABAergic transmission in the nucleus accumbens is involved in the termination of ethanol self-administration in rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Bicuculline; Dose-Response Relationship, Drug; gamma-Aminobut | 1995 |
Effect of dorsal raphe injections of the GABAA agonist, muscimol, on ethanol intake and measures of intoxication in Wistar rats.
Topics: Alcohol Drinking; Alcoholic Intoxication; Animals; Conditioning, Operant; Drinking Behavior; Ethanol | 1994 |
Decreases in dopamine receptors but not in dopamine transporters in alcoholics.
Topics: Adult; Alcohol Drinking; Alcoholism; Brain; Carbon Radioisotopes; Carrier Proteins; Corpus Striatum; | 1996 |
Regional densities of benzodiazepine sites in the CNS of alcohol-naive P and NP rats.
Topics: Alcohol Drinking; Animals; Autoradiography; Benzodiazepines; Brain; Flunitrazepam; gamma-Aminobutyri | 1997 |
A case report of reduction in alcohol craving and protection against alcohol withdrawal by gabapentin.
Topics: Acetates; Adult; Alcohol Drinking; Alcoholism; Amines; Animals; Anticonvulsants; Comorbidity; Cycloh | 1999 |
Cation modulation of GABA(A) receptors in brain sections of AT and ANT rats.
Topics: Alcohol Drinking; Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cations; Convulsants; Dos | 2001 |
Localization of the primary sites of genetic influence.
Topics: Alcohol Drinking; Animals; Chromosome Inversion; Crosses, Genetic; gamma-Aminobutyric Acid; Motor Sk | 1992 |
Betwixt gene and behavior.
Topics: Alcohol Drinking; Animals; Arousal; Crosses, Genetic; gamma-Aminobutyric Acid; Motor Skills; Phenoty | 1992 |
"Whole-animal" inverse and positive line differences.
Topics: Alcohol Drinking; Animals; Arousal; Crosses, Genetic; gamma-Aminobutyric Acid; Motor Skills; Phenoty | 1992 |
GABAergic involvement in the acquisition of voluntary ethanol intake in laboratory rats.
Topics: Alcohol Drinking; Animals; Baclofen; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Isoxazole | 1992 |
Microstructural analysis of the effects of THIP, a GABAA agonist, on voluntary ethanol intake in laboratory rats.
Topics: Alcohol Drinking; Animals; Conditioning, Operant; Eating; gamma-Aminobutyric Acid; Isoxazoles; Male; | 1992 |
gamma-Aminobutyric acid-activated chloride channels in rats selectively bred for differential acute sensitivity to alcohol.
Topics: Alcohol Drinking; Animals; Chloride Channels; Diazepam; Female; Flunitrazepam; gamma-Aminobutyric Ac | 1991 |
Acamprosate and diazepam differentially modulate alcohol-induced behavioural and cortical alterations in rats following chronic inhalation of ethanol vapour.
Topics: Acamprosate; Administration, Inhalation; Alcohol Drinking; Alcoholic Intoxication; Alcoholism; Anima | 1991 |
Depression among alcoholics. Relationship to clinical and cerebrospinal fluid variables.
Topics: Adult; Age Factors; Alcohol Drinking; Alcoholism; Anxiety Disorders; Depressive Disorder; Divorce; D | 1991 |
CSF gamma-aminobutyric acid in alcoholics and control subjects.
Topics: Adult; Age Factors; Alcohol Drinking; Alcoholism; Chromatography, Ion Exchange; Ethanol; Female; gam | 1990 |