Compounds > gamma-aminobutyric acid
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gamma-aminobutyric acid and Aging

gamma-aminobutyric acid has been researched along with Aging in 697 studies

gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Data from 4 phase 2/3 studies were pooled to characterize the exposure response of daily pregabalin (150-600 mg) in patients with fibromyalgia using self-assessed daily pain scores (PAIN) and end-of-treatment patient global impression of change (PGIC)."9.14Exposure-response analyses of the effects of pregabalin in patients with fibromyalgia using daily pain scores and patient global impression of change. ( Burger, P; Byon, W; Chew, M; Corrigan, B; Ito, K; Ouellet, D; Pauer, L; Zeiher, B, 2010)
"To determine the relative tolerability and efficacy of two newer antiepileptic drugs, lamotrigine (LTG) and gabapentin (GBP), as compared to carbamazepine (CBZ) in older patients with epilepsy."9.11New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine. ( Boardman, KD; Carter, GS; Collins, JF; Felicetta, J; Frederick, T; Marks, W; Pryor, F; Ramsay, RE; Rowan, AJ; Spitz, M; Tomyanovich, ML; Towne, A; Uthman, BM, 2005)
" Prolonged supplementation with both melatonin and SkQ1 (separately) suppressed the progression of the AMD-like pathology in OXYS rats without affecting the glutamate/GABA system but worsened the condition of the Wistar rat's retina during normal aging."8.12The glutamate/GABA system in the retina of male rats: effects of aging, neurodegeneration, and supplementation with melatonin and antioxidant SkQ1. ( Antonenko, AK; Fursova, AZ; Kolosova, NG; Telegina, DV, 2022)
"Aging is known to affect adversely the corticosterone status and the brain function including cognition."7.96Calorie restriction improves aging-induced impairment of cognitive function in relation to deregulation of corticosterone status and brain regional GABA system. ( Banerjee, S; Chakraborty, A; Mukherjee, B; Poddar, MK, 2020)
"The releases of endogenous glutamate, aspartate, GABA and taurine from hippocampal slices from 7-day-, 3-, 12-, and 18-month-old mice were investigated under cell-damaging conditions using a superfusion system."7.70Release of endogenous glutamate, aspartate, GABA, and taurine from hippocampal slices from adult and developing mice under cell-damaging conditions. ( Oja, SS; Saransaari, P, 1998)
"Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats."7.68Age dependency of the susceptibility of rats to aminooxyacetic acid seizures. ( Cavalheiro, EA; Dziki, M; Kleinrok, Z; Parada, J; Turski, W, 1992)
"The effects of progabide, a direct gamma-aminobutyric acid (GABA) receptor agonist, on bicuculline-induced seizures have been tested in developing rats, ages 7-28 days, to study the correlation between the antiepileptic effectiveness of this drug and the level of functional maturation of the GABAergic system."7.67Effects of progabide on bicuculline-induced epileptic seizures in developing rats. ( de Feo, MR; Mecarelli, O; Ricci, GF; Rina, MF, 1988)
"The properties of gamma-aminobutyric acid recognition sites, benzodiazepine binding sites and the effect of exogeneous gamma-aminobutyric acid on benzodiazepine binding were determined in crude membrane fractions prepared from the brains of DBA/2 mice at ages before (8-9 and 17-18 days), during (22-23 and 28-29 days) and after (40-43 days) the age of high susceptibility to audiogenic seizures."7.66gamma-Aminobutyric acid and benzodiazepine binding sites in audiogenic seizure-susceptible mice. ( Horton, RW; Meldrum, BS; Prestwich, SA, 1982)
" However, patients on the same PGB dosage per body weight had rather different PGB trough concentrations, which could be explained only in part by age and comedication."6.73Serum concentrations of pregabalin in patients with epilepsy: the influence of dose, age, and comedication. ( Jürgens, U; May, TW; Neb, R; Rambeck, B, 2007)
"The most common etiology was cerebral infarction."6.71New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine. ( Boardman, KD; Carter, GS; Collins, JF; Felicetta, J; Frederick, T; Marks, W; Pryor, F; Ramsay, RE; Rowan, AJ; Spitz, M; Tomyanovich, ML; Towne, A; Uthman, BM, 2005)
" The ameliorative effect of FDH-GABA on premature aging showed a clear dose-response relationship, and at the same time, the changes of intestinal microorganisms showed a certain correlation with the relevant indexes of nervous system."6.44Beneficial effect of GABA-rich fermented milk whey on nervous system and intestinal microenvironment of aging mice induced by D-galactose. ( He, W; Jiang, Y; Min, J; Song, H; Yang, Z; Zhao, S, 2024)
"Taurine release was doubled in hypoxia and tripled in ischemia but K+ stimulation was abolished."5.30Release of endogenous glutamate, aspartate, GABA, and taurine from hippocampal slices from adult and developing mice under cell-damaging conditions. ( Oja, SS; Saransaari, P, 1998)
"Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats."5.28Age dependency of the susceptibility of rats to aminooxyacetic acid seizures. ( Cavalheiro, EA; Dziki, M; Kleinrok, Z; Parada, J; Turski, W, 1992)
"Data from 4 phase 2/3 studies were pooled to characterize the exposure response of daily pregabalin (150-600 mg) in patients with fibromyalgia using self-assessed daily pain scores (PAIN) and end-of-treatment patient global impression of change (PGIC)."5.14Exposure-response analyses of the effects of pregabalin in patients with fibromyalgia using daily pain scores and patient global impression of change. ( Burger, P; Byon, W; Chew, M; Corrigan, B; Ito, K; Ouellet, D; Pauer, L; Zeiher, B, 2010)
"To determine the relative tolerability and efficacy of two newer antiepileptic drugs, lamotrigine (LTG) and gabapentin (GBP), as compared to carbamazepine (CBZ) in older patients with epilepsy."5.11New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine. ( Boardman, KD; Carter, GS; Collins, JF; Felicetta, J; Frederick, T; Marks, W; Pryor, F; Ramsay, RE; Rowan, AJ; Spitz, M; Tomyanovich, ML; Towne, A; Uthman, BM, 2005)
" We used matrix-assisted laser desorption/ionization mass spectrometry imaging in combination with multivariate analysis to visualize in anatomical detail metabolic effects of aging and tacrine-mediated acetylcholinesterase inhibition on comprehensive neurotransmitter systems in multiple mouse brain regions of 12-week-old and 14-month-old mice."4.12Region-Specific and Age-Dependent Multitarget Effects of Acetylcholinesterase Inhibitor Tacrine on Comprehensive Neurotransmitter Systems. ( Andrén, PE; Fridjonsdottir, E; Mantas, I; Nilsson, A; Odell, LR; Schembri, LS; Shariatgorji, R; Svenningsson, P; Vallianatou, T, 2022)
" Prolonged supplementation with both melatonin and SkQ1 (separately) suppressed the progression of the AMD-like pathology in OXYS rats without affecting the glutamate/GABA system but worsened the condition of the Wistar rat's retina during normal aging."4.12The glutamate/GABA system in the retina of male rats: effects of aging, neurodegeneration, and supplementation with melatonin and antioxidant SkQ1. ( Antonenko, AK; Fursova, AZ; Kolosova, NG; Telegina, DV, 2022)
"Aging is known to affect adversely the corticosterone status and the brain function including cognition."3.96Calorie restriction improves aging-induced impairment of cognitive function in relation to deregulation of corticosterone status and brain regional GABA system. ( Banerjee, S; Chakraborty, A; Mukherjee, B; Poddar, MK, 2020)
" Motor learning modulates the GABAergic (gamma-aminobutyric acid) system within the sensorimotor cortex (SM); however, it is unclear whether different practice regimes differentially modulate this system and whether this is impacted by aging."3.88The neurochemical basis of the contextual interference effect. ( Chalavi, S; Edden, RAE; Heise, KF; Maes, C; Pauwels, L; Puts, NAJ; Swinnen, SP; Zivari Adab, H, 2018)
"Pregabalin (PGB) is extensively prescribed to treat neurological and neuropsychiatrical conditions such as neuropathic pain, anxiety disorders, and epilepsy."3.85Chronic pregabalin treatment decreases excitability of dentate gyrus and accelerates maturation of adult-born granule cells. ( Coll, L; Lempel, AA; Piriz, J; Schinder, AF; Uchitel, OD, 2017)
" The regional neurochemical profile evolution indicated that aging induces general modifications of neurotransmission processes (reduced GABA and glutamate), primary energy metabolism (altered glucose, alanine, and lactate) and turnover of lipid membranes (modification of choline-containing compounds and phosphorylethanolamine), which are all probably involved in the frequently observed age-related cognitive decline."3.80Longitudinal neurochemical modifications in the aging mouse brain measured in vivo by 1H magnetic resonance spectroscopy. ( Do, KQ; Duarte, JM; Gruetter, R, 2014)
"Changes in the levels of gamma-aminobutyric acid (GABA) are known to occur in different parts of the brain during aging."3.75Age-related changes in GAD levels in the central auditory system of the rat. ( Burianova, J; Ouda, L; Profant, O; Syka, J, 2009)
" In ganglion and amacrine cells, fura-2 imaging showed that before postnatal day (P) 6, exogenous GABA, acting via ionotropic GABA receptors, evoked calcium rise, which persisted in HCO3- -free buffer but was blocked with 0 extracellular calcium."3.73Shift of intracellular chloride concentration in ganglion and amacrine cells of developing mouse retina. ( Coulter, DA; Freed, MA; Pathak, HR; Vardi, N; Zhang, LL, 2006)
" Tetanic stimulation of cholinergic afferents to release endogenous acetylcholine, or an exogenous application of the nAChR agonist cytisine, increased the frequency of spontaneous IPSCs in young rats; however these effects were not evident in aged rats, indicating that the nicotinic control of GABA release is lowered during aging."3.73Age-related alterations of GABAergic input to CA1 pyramidal neurons and its control by nicotinic acetylcholine receptors in rat hippocampus. ( Dutar, P; Epelbaum, J; Jouvenceau, A; Potier, B, 2006)
"The neonatal ventral hippocampal lesion in the rat has been used as a model of schizophrenia, a human disorder associated with changes in markers of dopamine and gamma-aminobutyric acid (GABA) circuits in various regions of the brain."3.72The neonatal ventral hippocampal lesion model of schizophrenia: effects on dopamine and GABA mRNA markers in the rat midbrain. ( Khaing, ZZ; Lerman, DN; Lipska, BK; Weinberger, DR, 2003)
" Using Ca(2+) imaging and patch clamp in a flat-mount perinatal rabbit retinal preparation, this study demonstrates that, in addition to the cholinergic system, a strychnine-sensitive system in the inner retina plays an obligatory and developmentally regulated role in the initiation and propagation of spontaneous retinal waves."3.71A critical role of the strychnine-sensitive glycinergic system in spontaneous retinal waves of the developing rabbit. ( Zhou, ZJ, 2001)
"The releases of endogenous glutamate, aspartate, GABA and taurine from hippocampal slices from 7-day-, 3-, 12-, and 18-month-old mice were investigated under cell-damaging conditions using a superfusion system."3.70Release of endogenous glutamate, aspartate, GABA, and taurine from hippocampal slices from adult and developing mice under cell-damaging conditions. ( Oja, SS; Saransaari, P, 1998)
"The action of progabide against motor seizures elicited by pentylenetetrazol was studied in 7-, 12-, 18-, 25-day-old and adult rats."3.69Anticonvulsant effect of progabide in rats during ontogenesis. ( Kozuchová, A; Mares, P; Stanková, L, 1997)
"Brain aging decreases binding of tert-butylbicyclophosphorothionate (TBPS), a specific ligand for Cl- channels, but has no effect on Cl- influx."3.69Age-related changes of GABA-activated chloride channel properties in brain cortex synaptic plasma membrane: evidence for phospholipase involvement. ( Samochocki, M; Strosznajder, J, 1994)
"Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats."3.68Age dependency of the susceptibility of rats to aminooxyacetic acid seizures. ( Cavalheiro, EA; Dziki, M; Kleinrok, Z; Parada, J; Turski, W, 1992)
"gamma-Aminobutyric acid (GABA) has been implicated in the development of hypertension and in the regulation of blood pressure."3.67The GABA/benzodiazepine receptor complex in the nervous system of a hypertensive strain of rat. ( Head, RA; Tunnicliff, G; Welborn, KL, 1984)
"The effects of progabide, a direct gamma-aminobutyric acid (GABA) receptor agonist, on bicuculline-induced seizures have been tested in developing rats, ages 7-28 days, to study the correlation between the antiepileptic effectiveness of this drug and the level of functional maturation of the GABAergic system."3.67Effects of progabide on bicuculline-induced epileptic seizures in developing rats. ( de Feo, MR; Mecarelli, O; Ricci, GF; Rina, MF, 1988)
"The properties of gamma-aminobutyric acid recognition sites, benzodiazepine binding sites and the effect of exogeneous gamma-aminobutyric acid on benzodiazepine binding were determined in crude membrane fractions prepared from the brains of DBA/2 mice at ages before (8-9 and 17-18 days), during (22-23 and 28-29 days) and after (40-43 days) the age of high susceptibility to audiogenic seizures."3.66gamma-Aminobutyric acid and benzodiazepine binding sites in audiogenic seizure-susceptible mice. ( Horton, RW; Meldrum, BS; Prestwich, SA, 1982)
"Thirty adults (17 with mild cognitive impairment [MCI]), ranging in age from 55 to 87 years, were enrolled and successfully completed the study."2.78Growth hormone-releasing hormone effects on brain γ-aminobutyric acid levels in mild cognitive impairment and healthy aging. ( Baker, LD; Barsness, SM; Borson, S; Craft, S; Friedman, SD; Jensen, JE; Merriam, GR; Novotny, EJ; Otto, RK; Vitiello, MV, 2013)
"Patients with diabetic polyneuropathy were examined to study their biological age, rate of aging and pain syndrome."2.76[Biological age and the pain syndrome at diabetic polyneuropathy]. ( Emel'ianov, VV; Galkin, VV; Nesterova, MV, 2011)
" However, patients on the same PGB dosage per body weight had rather different PGB trough concentrations, which could be explained only in part by age and comedication."2.73Serum concentrations of pregabalin in patients with epilepsy: the influence of dose, age, and comedication. ( Jürgens, U; May, TW; Neb, R; Rambeck, B, 2007)
"The most common etiology was cerebral infarction."2.71New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine. ( Boardman, KD; Carter, GS; Collins, JF; Felicetta, J; Frederick, T; Marks, W; Pryor, F; Ramsay, RE; Rowan, AJ; Spitz, M; Tomyanovich, ML; Towne, A; Uthman, BM, 2005)
"The incidence of seizures is particularly high in the early ages of life."2.47Altered GABA signaling in early life epilepsies. ( Briggs, SW; Galanopoulou, AS, 2011)
" The ameliorative effect of FDH-GABA on premature aging showed a clear dose-response relationship, and at the same time, the changes of intestinal microorganisms showed a certain correlation with the relevant indexes of nervous system."2.44Beneficial effect of GABA-rich fermented milk whey on nervous system and intestinal microenvironment of aging mice induced by D-galactose. ( He, W; Jiang, Y; Min, J; Song, H; Yang, Z; Zhao, S, 2024)
"Menopause is the time of life when menstrual cycles cease, and is caused by reduced secretion of the ovarian hormones oestrogen and progesterone."2.44Menopause. ( Nelson, HD, 2008)
" Individualization of dosage and avoidance of unnecessary polypharmacy are essential for safe utilization of anti-epileptic drugs."2.44[Epilepsy in the elderly]. ( Yoshino, A, 2007)
"Although epilepsy was believed to have the highest incidence in childhood, recent epidemiologic studies revealed that the incidence increases markedly in elderly."2.44[Epilepsy in the elderly]. ( Yoshino, A, 2007)
"Central tinnitus is used herein either to designate a tinnitus that originates in the central auditory system, or to refer to a component of a peripherally generated tinnitus that is exaggerated by auditory brain mechanisms."2.39Central tinnitus and lateral inhibition: an auditory brainstem model. ( Gerken, GM, 1996)
"Depression affects approximately 5% of elderly people and its etiology might be related to chronic stress exposure during neurodevelopmental periods."1.51Adolescent stress increases depression-like behaviors and alters the excitatory-inhibitory balance in aged mice. ( Li, JT; Liu, X; Ma, YN; Si, TM; Su, YA; Sun, YX; Wang, H; Wang, HL, 2019)
"Age and sex are risk factors of Alzheimer's disease (AD)."1.48Sex- and age-specific modulation of brain GABA levels in a mouse model of Alzheimer's disease. ( Alia, A; Hartlage-Rübsamen, M; Höfling, C; Matysik, J; Roy, U; Roβner, S; Stute, L, 2018)
"Moreover, in mice carrying an Alzheimer's disease-related mutation in presenilin 1, astrocytes accumulated GABA even in the absence of amyloidosis."1.48A bell-shaped dependence between amyloidosis and GABA accumulation in astrocytes in a mouse model of Alzheimer's disease. ( Brawek, B; Chesters, R; Garaschuk, O; Hermes, M; Klement, D; Lerdkrai, C; Müller, J, 2018)
"Amyloid-β (Aβ) plaque accumulation in Alzheimer's disease (AD) is associated with glutamatergic synapse loss, but less is known about its effect on inhibitory synapses."1.39Altered synapses and gliotransmission in Alzheimer's disease and AD model mice. ( Dickson, TC; Kirkcaldie, MT; Mitew, S; Vickers, JC, 2013)
"However, it is unclear whether the conductive hearing loss caused by otitis media in early age will affect sound tolerance later in life."1.37Early age conductive hearing loss causes audiogenic seizure and hyperacusis behavior. ( Allman, B; Fu, Q; Jayaram, A; Kumaraguru, A; Li, J; Manohar, S; Sun, W, 2011)
"The oxytocin effect was mediated by uterine-type oxytocin receptors."1.36Oxytocin and vasopressin enhance synaptic transmission in the hypoglossal motor nucleus of young rats by acting on distinct receptor types. ( Dupré, A; Raggenbass, M; Reymond-Marron, I; Wrobel, LJ, 2010)
"Bumetanide is a specific inhibitor of this cotransporter."1.35Age- and dose-specific anticonvulsant action of bumetanide in immature rats. ( Mares, P, 2009)
"Pretreatment with bumetanide (0."1.35Age- and dose-specific anticonvulsant action of bumetanide in immature rats. ( Mares, P, 2009)
"When propranolol was administered at either 5-, 60-, or 120-min post-training, there was an inhibition of conditioned responses, these data support the hypothesis that NE is important for consolidation of learning."1.35Neurotransmitter release during delay eyeblink classical conditioning: role of norepinephrine in consolidation and effect of age. ( Avilas, M; Bickford, PC; Cartford, MC; Catlow, BJ; George, A; Paredes, DA; Samec, A; Schlunck, A; Small, B, 2009)
"As propofol is a GABAA agonist, we hypothesized that it and more specific GABAA modulators would increase intracellular free calcium ([Ca2+]i), resulting in the death of neonatal rat hippocampal neurons."1.35GABAergic mechanism of propofol toxicity in immature neurons. ( Fiskum, G; Kahraman, S; McCarthy, MM; Zup, SL, 2008)
"Febrile seizures are the most common seizure type in children, and hyperthermia may contribute to seizure generation during fever."1.35Effects of temperature elevation on neuronal inhibition in hippocampal neurons of immature and mature rats. ( Leung, LS; Qu, L, 2009)
"The zolpidem-induced increase of decay times, amplitude and charge transfer and alpha1-ir expression were the lowest in PN5-9 males but increased with age, in both genders."1.35Age- and gender-related differences in GABAA receptor-mediated postsynaptic currents in GABAergic neurons of the substantia nigra reticulata in the rat. ( Chudomel, O; Galanopoulou, AS; Herman, H; Moshé, SL; Nair, K, 2009)
"The metyrapone treatment produced no changes in GAD activity at PN23, but induced an important increase in this activity at PN90."1.34Role of maternal corticosterone in the development and maturation of the aminoacidergic systems of the rat brain. ( Garcia-Montojo, M; González, JC; Lecumberri, M; Leret, ML, 2007)
"Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter that is synthesized by two isoforms of glutamic acid decarboxylase (GAD), GAD65 and GAD67."1.33GABAergic neurons in the lateral superior olive of the hamster are distinguished by differential expression of gad isoforms during development. ( Jenkins, SA; Simmons, DD, 2006)
"In the immature hippocampus, seizures generated with functional GABAergic synapses include fast oscillations that are required to transform a naive network to an epileptic one: blocking GABA receptors prevents the long-lasting sequels of seizures."1.33Epileptogenic actions of GABA and fast oscillations in the developing hippocampus. ( Ben-Ari, Y; Gozlan, H; Khalilov, I; Le Van Quyen, M, 2005)
"Adenosine is a known inhibitor of respiratory output during early life."1.33Adenosine A2A receptors mediate GABAergic inhibition of respiration in immature rats. ( Haxhiu, MA; Martin, RJ; Mayer, CA; Wilson, CG, 2006)
"01), but GBP daily dosage or concomitant AEDs had no significant influence on the ratio."1.32Association between patient age and gabapentin serum concentration-to-dose ratio: a preliminary multivariate analysis. ( Adín, J; Armijo, JA; Pena, MA; Vega-Gil, N, 2004)
"The immature brain is prone to seizures but the underlying mechanisms are poorly understood."1.32Developmental changes in GABAergic actions and seizure susceptibility in the rat hippocampus. ( Ben-Ari, Y; Holmes, GL; Khalilov, I; Khazipov, R; Morozova, E; Tyzio, R, 2004)
" After 1-d or 14-d withdrawal from Amph, they were challenged on day 8 (W1d) or on day 21 (W14d) with a single same dosage and then perfused."1.32Age- and region-dependent alterations in the GABAergic innervation in the brain of rats treated with amphetamine. ( Chen, CT; Lin, TY; Yin, HS, 2004)
"The Fragile X syndrome, a common form of mental retardation in humans, is caused by silencing the fragile X mental retardation (FMR1) gene leading to the absence of the encoded fragile X mental retardation protein 1 (FMRP)."1.31Alterations of amino acids and monoamine metabolism in male Fmr1 knockout mice: a putative animal model of the human fragile X mental retardation syndrome. ( Braun, K; Gruss, M, 2001)
"Malondialdehyde (MDA) was measured as a marker of oxidative damage."1.31Diets enriched in foods with high antioxidant activity reverse age-induced decreases in cerebellar beta-adrenergic function and increases in proinflammatory cytokines. ( Bickford, PC; Choo, K; Gemma, C; Holmes, DB; Mesches, MH; Sepesi, B, 2002)
"A well known drug in the treatment of spasticity is the GABA(B) agonist Baclofen."1.31Baclofen inhibits ANP-mediated cyclic GMP synthesis in the rat cervical spinal cord. ( de Louw, AJ; de Vente, J; Steinbusch, HP; Steinbusch, HW; Troost, J; Vles, JS, 2002)
"Minimal seizures were not affected by solvent or progabide pretreatment."1.30Anticonvulsant effect of progabide in rats during ontogenesis. ( Kozuchová, A; Mares, P; Stanková, L, 1997)
"The action of progabide against motor seizures elicited by pentylenetetrazol was studied in 7-, 12-, 18-, 25-day-old and adult rats."1.30Anticonvulsant effect of progabide in rats during ontogenesis. ( Kozuchová, A; Mares, P; Stanková, L, 1997)
"SL 75 102 suppressed generalized tonic-clonic seizures in adult rats and restricted the tonic phase of these seizures in rat pups."1.30Anticonvulsant effect of SL 75 102 in adult and immature rats. ( Haugvicová, R; Kubová, H; Mares, P, 1997)
"Glycine and taurine were present at relatively low concentrations during the prenatal period, then rose significantly by about 4-fold after birth; their levels decreased by the end of the first postnatal week but increased gradually thereafter until reaching adult values by the third week."1.30Levels of amino acid neurotransmitters during mouse cerebellar neurogenesis and in histotypic cerebellar cultures. ( Benítez-Diaz, PR; Delgado-Saez, MC; Mendoza-Briceño, RV; Miranda-Contreras, L; Palacios-Prü, EL, 1999)
"Taurine release was doubled in hypoxia and tripled in ischemia but K+ stimulation was abolished."1.30Release of endogenous glutamate, aspartate, GABA, and taurine from hippocampal slices from adult and developing mice under cell-damaging conditions. ( Oja, SS; Saransaari, P, 1998)
"Sodium azide is an inhibitor of cytochrome oxidase which produces selective striatal lesions in both rodents and primates."1.29Systemic or local administration of azide produces striatal lesions by an energy impairment-induced excitotoxic mechanism. ( Beal, MF; Brouillet, E; Henshaw, DR; Hyman, BT; Jenkins, BG; Rosen, BR; Schulz, JB; Sodhi, P, 1994)
" Chronic administration of sodium azide for 1 month lead to striatal neuropathological changes."1.29Systemic or local administration of azide produces striatal lesions by an energy impairment-induced excitotoxic mechanism. ( Beal, MF; Brouillet, E; Henshaw, DR; Hyman, BT; Jenkins, BG; Rosen, BR; Schulz, JB; Sodhi, P, 1994)
" The plasma concentration ratio of the [R] to [S] enantiomers appears to remain constant across the vigabatrin dosage interval in adult volunteers, and in the present study this has also proved to be the case in 12 chronically treated adult epileptic patients."1.29Plasma vigabatrin enantiomer ratios in adults and children. ( Appleton, DB; Burke, CJ; Eadie, MJ; Nagarajan, L; Schramm, T, 1993)
"Apomorphine failed to produce similar increases in glutamate concentration in middle-aged and aged rats."1.29Dopamine--glutamate--GABA interactions and ageing: studies in the striatum of the conscious rat. ( Mora, F; Porras, A, 1995)
"No clinical seizure activity was observed during this period."1.29Hippocampal changes in developing postnatal mice following intrauterine exposure to domoic acid. ( Dakshinamurti, K; Sharma, SK; Sundaram, M; Watanabe, T, 1993)
"Domoic acid (0."1.29Hippocampal changes in developing postnatal mice following intrauterine exposure to domoic acid. ( Dakshinamurti, K; Sharma, SK; Sundaram, M; Watanabe, T, 1993)
"The glycine effect was strychnine-insensitive, characteristic of the glycine modulatory site in the N-methyl-D-aspartate receptor."1.29Regulation of D-aspartate release by glutamate and GABA receptors in cerebral cortical slices from developing and ageing mice. ( Oja, SS; Saransaari, P, 1994)
" In aged rats, the dose-response curve was shifted to the left, indicating an increase in the potency of GABA to inhibit [3H]t-butylbicycloorthobenzoate binding."1.29GABAA receptor binding in the aging rat inferior colliculus. ( Albin, RL; Caspary, DM; Milbrandt, JC; Turgeon, SM, 1996)
"Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats."1.28Age dependency of the susceptibility of rats to aminooxyacetic acid seizures. ( Cavalheiro, EA; Dziki, M; Kleinrok, Z; Parada, J; Turski, W, 1992)
"Putamen tissue from four cases of Huntington's disease showed a marked reduction in [3H]nipecotic acid binding."1.28[3H]nipecotic acid binding to gamma-aminobutyric acid uptake sites in postmortem human brain. ( Czudek, C; Reynolds, GP, 1990)
"Taurine was thus able to modulate GABA release through bicuculline-sensitive receptors, but this modulation was not evident in cerebellar slices from 7-day-old mice."1.28Release of taurine and GABA from cerebellar slices from developing and adult mice. ( Kontro, P; Oja, SS, 1989)
"gamma-Aminobutyric acid (GABA) has been implicated in the development of hypertension and in the regulation of blood pressure."1.27The GABA/benzodiazepine receptor complex in the nervous system of a hypertensive strain of rat. ( Head, RA; Tunnicliff, G; Welborn, KL, 1984)
"3."1.27Age-related changes in GABA and benzodiazepine receptor binding in rat brain are influenced by sampling time. ( Niles, LP; Pickering, DS; Pulido, OM, 1988)
"Muscimol pretreatment (dosages ranging from 0."1.27Ontogeny of GABA-ergic and dopaminergic mediation of gnawing behavior in the mouse. ( Tirelli, E, 1987)
"[3H]muscimol was used for the labeling of GABA receptors and [3H]flunitrazepam for benzodiazepine receptors."1.26Ontogeny of high-affinity GABA and benzodiazepine receptors in the rat cerebellum: an autoradiographic study. ( Kuhar, MJ; Palacios, JM, 1981)
"Taurine was present in large amounts in early fetal life and decreased slowly during neonatal life, arriving at amounts found in the mother not until after 150 days of age."1.26Sulfur amino acid metabolism in the developing rhesus monkey brain: subcellular studies of taurine, cysteinesulfinic acid decarboxylase, gamma-aminobutyric acid, and glutamic acid decarboxylase. ( Gaull, GE; Rassin, DK; Sturman, JA, 1981)
"Choline uptake was very low until 12 days postnatally, then the Vmax increased and approached adult values of 29 pmol/mg prot."1.26Developmental studies of the uptake of choline, GABA and dopamine by crude synaptosomal preparations after in vivo or in vitro lead treatment. ( Krigman, MR; Morell, P; Ramsay, PB, 1980)
" Similar studies were conducted with rats treated at the highest lead dosage which did not result in weight loss (100 microgram lead as lead acetate/g body weight/day via intubation)."1.26Developmental studies of the uptake of choline, GABA and dopamine by crude synaptosomal preparations after in vivo or in vitro lead treatment. ( Krigman, MR; Morell, P; Ramsay, PB, 1980)

Research

Studies (697)

TimeframeStudies, this research(%)All Research%
pre-1990146 (20.95)18.7374
1990's179 (25.68)18.2507
2000's216 (30.99)29.6817
2010's130 (18.65)24.3611
2020's26 (3.73)2.80

Authors

AuthorsStudies
Ahn, Y1
Hong, KB1
Kim, S1
Suh, HJ1
Jo, K1
Hone-Blanchet, A1
Bohsali, A1
Krishnamurthy, LC1
Shahid, S1
Lin, Q1
Zhao, L2
Loring, D1
Goldstein, F1
John, SE1
Fleischer, CC1
Levey, A1
Lah, J1
Qiu, D1
Crosson, B1
Petitet, P1
Spitz, G1
Emir, UE1
Johansen-Berg, H1
O'Shea, J1
Maes, C6
Cuypers, K5
Peeters, R2
Sunaert, S3
Edden, RAE6
Gooijers, J2
Swinnen, SP7
Fridjonsdottir, E1
Vallianatou, T1
Mantas, I1
Shariatgorji, R1
Nilsson, A1
Schembri, LS1
Odell, LR1
Svenningsson, P1
Andrén, PE1
Tu, J1
Jin, Y1
Zhuo, J1
Cao, X1
Liu, G1
Du, H1
Liu, L1
Wang, J2
Xiao, H1
Telegina, DV1
Antonenko, AK1
Fursova, AZ1
Kolosova, NG1
Mafi, AM1
Tokar, N1
Russ, MG1
Barat, O2
Mellott, JG2
Dong, J1
Guo, C1
Yang, Z2
Wu, Y1
Zhang, C1
Wu, J1
Wang, L1
Ervin, JF1
Wang, SJ1
Soderblom, E1
Ko, D1
Yan, D1
Lyssikatos, C1
Wang, Z2
Liu, Z1
Warden, SJ1
Bonewald, L1
Brotto, M1
He, W1
Song, H2
Zhao, S1
Min, J1
Jiang, Y2
Rozycka, A2
Charzynska, A1
Misiewicz, Z1
Maciej Stepniewski, T1
Sobolewska, A2
Kossut, M3
Liguz-Lecznar, M3
Hörtnagl, H1
Pifl, C1
Hörtnagl, E1
Reiner, A1
Sperk, G1
Nikitenko, T1
Chowdhury, N1
Puri, R1
He, JL1
Domínguez, S1
Rey, CC1
Therreau, L1
Fanton, A1
Massotte, D1
Verret, L1
Piskorowski, RA1
Chevaleyre, V1
Varlinskaya, EI1
Johnson, JM1
Przybysz, KR2
Deak, T1
Diaz, MR2
Qin, X1
He, Y1
Wang, N1
Zou, JX1
Zhang, YM1
Cao, JL1
Pan, BX1
Zhang, WH1
Pan-Vazquez, A1
Wefelmeyer, W1
Gonzalez Sabater, V1
Neves, G1
Burrone, J1
Koh, MT1
Branch, A1
Haberman, R1
Gallagher, M1
Chakraborty, A1
Banerjee, S1
Mukherjee, B1
Poddar, MK4
King, BR1
Rumpf, JJ1
Verbaanderd, E1
Heise, KF4
Dolfen, N1
Doyon, J1
Classen, J1
Mantini, D2
Puts, NAJ3
Albouy, G1
Richardson, BD2
Sottile, SY1
Caspary, DM10
Dobri, SGJ1
Ross, B1
Oruro, EM1
Pardo, GVE1
Lucion, AB1
Calcagnotto, ME2
Idiart, MAP1
Chamberlain, JD1
Gagnon, H3
Lalwani, P3
Cassady, KE1
Simmonite, M4
Seidler, RD3
Taylor, SF3
Weissman, DH4
Park, DC1
Polk, TA4
Elgueta-Reyes, M1
Martínez-Pinto, J1
Renard, GM1
Sotomayor-Zárate, R1
Porges, EC2
Jensen, G1
Foster, B1
Edden, RA3
Puts, NA2
Mooney, RA1
Cirillo, J1
Byblow, WD1
Kondo, HM1
Kochiyama, T1
Godfrey, DA1
Chen, K1
O'Toole, TR1
Mustapha, AIAA1
Brecht, EJ1
Barsz, K1
Gross, B1
Walton, JP1
Woods, AJ1
Lamb, DG1
Williamson, JB1
Cohen, RA1
Harris, AD2
Daher, I1
Le Dieu-Lugon, B1
Dourmap, N1
Lecuyer, M1
Ramet, L1
Gomila, C1
Ausseil, J1
Marret, S2
Leroux, P1
Roy, V1
El Mestikawy, S1
Daumas, S1
Gonzalez, B1
Leroux-Nicollet, I1
Cleren, C1
Prud'homme, GJ1
Glinka, Y1
Kurt, M1
Liu, W1
Wang, Q1
Bao, H1
Asrican, B1
Li, W2
Gu, B1
Wen, Z1
Lim, SA1
Haniff, I1
Ramakrishnan, C1
Deisseroth, K1
Philpot, B1
Song, J1
Brawek, B1
Chesters, R1
Klement, D1
Müller, J1
Lerdkrai, C1
Hermes, M1
Garaschuk, O2
Li, Y2
Yu, L1
Zeng, F1
Liu, QS2
Roy, U1
Stute, L1
Höfling, C1
Hartlage-Rübsamen, M1
Matysik, J1
Roβner, S1
Alia, A1
Bondar, T1
Carmona, J1
Gao, K1
Benedetti, B1
Basson, M1
Levinson, R1
Stower, H1
Farrell, A1
Chalavi, S2
Pauwels, L3
Zivari Adab, H1
Hermans, L2
Leunissen, I2
Levin, O1
Hasanpour, M1
Nourazarian, A1
Geranmayeh, MH1
Nikanfar, M1
Khaki-Khatibi, F1
Rahbarghazi, R1
Cui, B1
Su, D1
She, X1
Zhang, M1
Wang, R2
Zhai, Q1
Marenco, S1
Meyer, C1
van der Veen, JW1
Zhang, Y2
Kelly, R1
Shen, J1
Weinberger, DR2
Dickinson, D1
Berman, KF1
Carp, J1
Foerster, BR1
Ossher, L1
Petrou, M2
Cassady, K2
Foerster, B1
Park, D1
Peltier, SJ1
Davydova, TV1
Gruden, MA1
Kudrin, VS1
Narkevich, VB1
Vetrile, LA1
Zakharova, IA1
Sewell, RDE1
Pandya, M1
Palpagama, TH1
Turner, C1
Waldvogel, HJ1
Faull, RL1
Kwakowsky, A1
Pal, I1
Paltati, CRB1
Kaur, C1
Kumar, P1
Jacob, TG1
Bhardwaj, DN2
Roy, TS2
Quevenco, FC1
Schreiner, SJ1
Preti, MG1
van Bergen, JMG1
Kirchner, T1
Wyss, M1
Steininger, SC1
Gietl, A1
Leh, SE1
Buck, A1
Pruessmann, KP1
Hock, C1
Nitsch, RM1
Henning, A1
Van De Ville, D1
Unschuld, PG2
Pozdnyakova, N1
Dudarenko, M1
Borisova, T1
Robinson, LC1
Wang, HL1
Sun, YX1
Liu, X1
Wang, H3
Ma, YN1
Su, YA1
Li, JT1
Si, TM1
Peltier, S1
Hoshino, O3
Gao, F1
Li, M1
Wang, G1
Liu, C2
Zhao, B1
Bai, X1
Zhao, C1
Wang, X1
Barker, PB2
Mitew, S1
Kirkcaldie, MT1
Dickson, TC1
Vickers, JC1
Lee, CY1
Liou, HH1
Friedman, SD1
Baker, LD1
Borson, S1
Jensen, JE1
Barsness, SM1
Craft, S1
Merriam, GR1
Otto, RK1
Novotny, EJ1
Vitiello, MV1
Koyama, Y1
Andoh, T1
Kamiya, Y1
Morita, S1
Miyazaki, T1
Uchimoto, K1
Mihara, T1
Goto, T1
Liu, J2
Zhang, B1
Lei, H2
Feng, Z1
Hsu, AL1
Xu, XZ1
Mori, T1
Mori, K1
Ito, H1
Goji, A1
Miyazaki, M1
Harada, M1
Kurosawa, K1
Kagami, S1
Ohira, K1
Takeuchi, R1
Iwanaga, T1
Miyakawa, T1
Lazarus, MS1
Krishnan, K1
Huang, ZJ1
Sharma, S1
Nag, TC1
Thakar, A1
Rossiter, HE1
Davis, EM1
Clark, EV1
Boudrias, MH1
Ward, NS1
Duarte, JM1
Do, KQ1
Gruetter, R2
Lehner, M1
Kaliszewska, A1
Zakrzewska, R1
Zhu, S1
He, J1
Adilijiang, A1
Zhang, H3
Hartle, K1
Guo, H1
Kong, J1
Huang, Q1
Li, XM2
Gleich, O3
Netz, J1
Strutz, J3
Tatarishvili, J1
Oki, K1
Monni, E1
Koch, P1
Memanishvili, T1
Buga, AM1
Verma, V1
Popa-Wagner, A1
Brüstle, O1
Lindvall, O1
Kokaia, Z1
Moradi-Chameh, H1
Peng, J1
Wu, C1
Zhang, L1
Cusmano, DM1
Mong, JA3
Kenney, MJ1
Mora-Gallegos, A1
Rojas-Carvajal, M1
Salas, S1
Saborío-Arce, A1
Fornaguera-Trías, J1
Brenes, JC1
Li, MH1
Suchland, KL1
Ingram, SL1
Brown, AR1
Herd, MB1
Belelli, D1
Lambert, JJ1
Willing, J1
Juraska, JM1
McQuail, JA2
Frazier, CJ2
Bizon, JL3
Sawano, E1
Iwatani, K1
Tominaga-Yoshino, K1
Ogura, A1
Tashiro, T1
Beas, BS1
Ban Uelos, C1
Setlow, B1
Albrecht, A1
Ivens, S1
Papageorgiou, IE1
Çalışkan, G1
Saiepour, N1
Brück, W1
Richter-Levin, G1
Heinemann, U3
Stork, O1
Tong, LM1
Yoon, SY1
Andrews-Zwilling, Y1
Yang, A1
Lin, V1
Huang, Y1
Brandt, AS1
Pradhan, S1
Lim, IA1
Churchill, G1
Hua, J1
Ross, CA1
van Zijl, PC1
Margolis, RL1
Fei, F1
Lee, KM1
McCarry, BE1
Bowdish, DM1
Liao, C1
Han, Q1
Ma, Y2
Su, B1
Du, Z1
Chazalon, M1
Bestaven, E1
Leste-Lasserre, T1
Baufreton, J1
Cazalets, JR1
Cho, YH1
Garret, M2
Oh, H1
Lewis, DA4
Sibille, E1
Lempel, AA1
Coll, L1
Schinder, AF1
Uchitel, OD1
Piriz, J1
Carpenter, HE1
Kelly, KB1
Caporali, P1
Bruno, F1
Palladino, G1
Dragotto, J1
Petrosini, L2
Mangia, F1
Erickson, RP1
Canterini, S1
Fiorenza, MT1
Mojabi, FS1
Fahimi, A1
Moghadam, S2
Windy McNerneny, M1
Ponnusamy, R1
Kleschevnikov, A1
Mobley, WC1
Salehi, A1
Aracri, P1
Meneghini, S1
Coatti, A1
Amadeo, A2
Becchetti, A2
Villanueva-Castillo, C1
Tecuatl, C1
Herrera-López, G1
Galván, EJ1
Huang, D1
Liu, D1
Yin, J1
Qian, T1
Shrestha, S1
Ni, H1
Oyelami, T1
Bondt, A1
den Wyngaert, IV1
Hoorde, KV1
Hoskens, L1
Shaban, H1
Kemp, JA1
Drinkenburg, WH1
Ladrón de Guevara-Miranda, D1
Millón, C1
Rosell-Valle, C1
Pérez-Fernández, M1
Missiroli, M1
Serrano, A1
Pavón, FJ1
Rodríguez de Fonseca, F1
Martínez-Losa, M1
Álvarez-Dolado, M1
Santín, LJ1
Castilla-Ortega, E1
Werner, DF1
Noda, Y1
Zomorrodi, R1
Cash, RF1
Barr, MS1
Farzan, F1
Rajji, TK1
Chen, R1
Daskalakis, ZJ1
Blumberger, DM1
Imoto, Y1
Segi-Nishida, E1
Suzuki, H1
Kobayashi, K1
Tyzio, R2
Minlebaev, M1
Rheims, S1
Ivanov, A1
Jorquera, I1
Holmes, GL3
Zilberter, Y1
Ben-Ari, Y10
Khazipov, R3
Pisu, MG1
Mostallino, MC1
Dore, R1
Mura, ML1
Maciocco, E1
Russo, E1
De Sarro, G1
Serra, M1
Qu, L3
Leung, LS3
Neal-Perry, GS1
Zeevalk, GD1
Shu, J1
Etgen, AM1
Béldi, M1
Takács, J1
Bárdos, G1
Világi, I1
Reynoso, R2
Ponzo, O2
Cardoso, N1
Szwarcfarb, B4
Carbone, S4
Moguilevsky, J2
Scacchi, P2
Nakamura, S3
Inoue, T1
Nakajima, K1
Moritani, M1
Nakayama, K1
Tokita, K1
Yoshida, A1
Maki, K1
El-faramawy, YA1
El-banouby, MH1
Sergeev, P1
Mortagy, AK1
Amer, MS1
Abdel-tawab, AM1
Paredes, DA1
Cartford, MC1
Catlow, BJ1
Samec, A1
Avilas, M1
George, A1
Schlunck, A1
Small, B1
Bickford, PC9
Kahraman, S1
Zup, SL1
McCarthy, MM6
Fiskum, G1
Wójtowicz, T2
Lebida, K1
Mozrzymas, JW2
Burianova, J1
Ouda, L1
Profant, O1
Syka, J1
Tseng, KY1
Lewis, BL1
Hashimoto, T1
Sesack, SR2
Kloc, M1
O'Donnell, P1
Hua, T2
Li, G1
Tang, C1
Chang, S1
Xu, C1
Cui, C1
Alkon, DL1
Hammarlund, M1
Nix, P1
Hauth, L1
Jorgensen, EM1
Bastiani, M1
Oja, SS9
Saransaari, P5
Watanabe, M1
Sakuma, Y1
Kato, M1
Dugan, LL1
Ali, SS1
Shekhtman, G1
Roberts, AJ1
Lucero, J1
Quick, KL1
Behrens, MM1
Chudomel, O1
Herman, H1
Nair, K1
Moshé, SL4
Galanopoulou, AS2
Lasztóczi, B1
Nyitrai, G1
Héja, L1
Kardos, J1
Liu, P2
Jing, Y1
Yee, CL1
Wang, Y2
Anderson, S1
Ekker, M1
Rubenstein, JL2
Madhusudan, A1
Sidler, C1
Knuesel, I1
Magno, L1
Catanzariti, V1
Nitsch, R1
Krude, H1
Naumann, T1
Hughes, LF2
Turner, JG1
Parrish, JL1
Constantin, S1
Jasoni, CL1
Wadas, B1
Herbison, AE3
Turner, CP1
DeBenedetto, D1
Ware, E1
Stowe, R1
Lee, A1
Swanson, J1
Walburg, C1
Lambert, A1
Lyle, M1
Desai, P1
Wrobel, LJ1
Reymond-Marron, I1
Dupré, A1
Raggenbass, M1
Yazaki-Sugiyama, Y1
Kang, S1
Câteau, H1
Fukai, T1
Hensch, TK2
Bonner, JF1
Blesch, A1
Neuhuber, B1
Fischer, I1
Boyce, R1
Goaillard, JM1
Mares, P4
Rajalu, M1
Müller, UC1
Caley, A1
Harvey, RJ1
Poisbeau, P2
Lonchamp, E1
Dupont, JL1
Doussau, F1
Shin, HS1
Poulain, B1
Bossu, JL1
Shetty, AK1
Hattiangady, B1
Rao, MS1
De Bartolo, P1
Cutuli, D1
Ricceri, L1
Gelfo, F1
Foti, F1
Laricchiuta, D1
Scattoni, ML1
Calamandrei, G1
Zhang, ZW1
Zak, JD1
Liu, H1
Martínez-Cerdeño, V1
Noctor, SC1
Espinosa, A1
Ariza, J1
Parker, P1
Orasji, S1
Daadi, MM1
Bankiewicz, K1
Alvarez-Buylla, A1
Kriegstein, AR1
Byon, W1
Ouellet, D1
Chew, M1
Ito, K1
Burger, P1
Pauer, L1
Zeiher, B1
Corrigan, B1
Khan, M1
De Sevilla, L1
Mahesh, VB1
Brann, DW1
Hamer, G1
Matilainen, O1
Holmberg, CI1
Koyanagi, Y1
Yamamoto, K1
Oi, Y1
Koshikawa, N1
Kobayashi, M1
Brown, MN1
Mathews, GC1
Baba, Y1
Tukada, A1
Ogawa, H1
Campbell, NR1
Fernandes, CC1
Halff, AW1
Berg, DK1
Devaraj, R1
Ganesalingam, GS1
Smith, PF1
Lanoue, AC1
Dumitriu, A1
Myers, RH1
Soghomonian, JJ1
Shah, D1
Agrawal, S1
Jiang, B1
Sohya, K1
Sarihi, A1
Yanagawa, Y1
Tsumoto, T1
Khundakar, A1
Morris, C1
Thomas, AJ1
Fujiwara, H1
Zheng, M1
Miyamoto, A2
Karnani, MM1
Venner, A1
Jensen, LT1
Fugger, L1
Burdakov, D1
Stanley, EM1
Fadel, JR1
Mott, DD1
Yang, H1
Pang, W1
Lu, H1
Cheng, D1
Yan, X1
Cheng, Y1
Gao, XP1
Liu, Q2
Wong-Riley, MT2
Fleming, RL1
Acheson, SK1
Moore, SD1
Wilson, WA1
Swartzwelder, HS1
Luo, B1
Wang, HT1
Su, YY1
Wu, SH1
Chen, L1
Albayram, O1
Alferink, J1
Pitsch, J1
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Neitzert, K1
Poppensieker, K1
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Legler, A1
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Hennig, MH1
Grady, J1
van Coppenhagen, J1
Sernagor, E1
Sun, W1
Manohar, S1
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Li, J2
Allman, B1
Masiulis, I1
Yun, S1
Eisch, AJ1
Galkin, VV2
Nesterova, MV2
Emel'ianov, VV1
Tujioka, K2
Ohsumi, M1
Sakamoto, K1
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Akao, M1
Kim, M2
Hayase, K2
Yokogoshi, H2
Huang, J1
Lin, Y1
Han, R1
Chen, J1
Wang, YY1
Wang, W1
Wei, YY1
Kaneko, T1
Li, YQ1
Wu, SX1
Dahmani, S1
Tourrel, F1
Blanc, T1
Jegou-Colleter, S1
Laudenbach, V1
Chiang, PH1
Wu, PY1
Kuo, TW1
Liu, YC1
Chan, CF1
Chien, TC1
Cheng, JK1
Huang, YY1
Chiu, CD1
Lien, CC1
Haam, J1
Popescu, IR1
Morton, LA1
Halmos, KC1
Teruyama, R1
Ueta, Y1
Tasker, JG1
Vaccaro, A1
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Rouleau, G1
Drapeau, P1
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Aufhaus, E1
Weber-Fahr, W1
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Oberthuer, G1
Hoerst, M1
Meyer-Lindenberg, A1
Boettcher, U1
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Baroncelli, L1
Viegi, A1
Tiraboschi, E1
Castren, E1
Cattaneo, A1
Maffei, L1
Lehmann, K1
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Bolz, J1
Hasegawa, J1
Yang, JM1
Zhang, J1
Yu, YQ1
Duan, S1
Hsieh, YC1
Puche, AC1
Llano, DA1
Turner, J1
Ling, LL1
Uteshev, VV1
Gemma, C1
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Sepesi, B1
Choo, K1
Holmes, DB1
Amateau, SK1
Morales, B1
Choi, SY1
Kirkwood, A1
Moon, JS1
Kim, JJ1
Chang, IY1
Chung, YY1
Jun, JY1
You, HJ1
Yoon, SP1
Dlugos, CA1
Pentney, RJ1
Kraushaar, U1
Backus, KH1
Burke, RE1
Al-Sarraf, H1
Sobkowicz, HM1
August, BK1
Slapnick, SM1
Perreault, MC1
Qin, Y1
Heggelund, P1
Zhu, JJ1
Momiyama, T1
Okada, M2
Zhu, G1
Hirose, S1
Ito, KI1
Murakami, T1
Wakui, M1
Kaneko, S1
Kim, G1
Kandler, K2
Jolas, T1
Zhang, XS1
Zhang, Q1
Wong, G1
Del Vecchio, R1
Gold, L1
Priestley, T1
Obermair, GJ1
Kaufmann, WA1
Knaus, HG1
Flucher, BE1
Dzhala, VI1
Staley, KJ1
Vela, J1
Gutierrez, A2
Vitorica, J5
Ruano, D5
Mtchedlishvili, Z1
Sun, CS1
Harrison, MB1
Kapur, J1
Ben-Yaakov, G1
Golan, H2
Cannizzaro, C1
Martire, M1
Cannizzaro, E1
Monastero, R1
Gagliano, M1
Mineo, A1
Provenzano, G1
Miller, G1
Leventhal, AG1
Pu, M1
Zhou, Y3
Lorke, DE2
Wong, LY1
Lai, HW1
Poon, PW1
Zhang, A1
Chan, WY1
Yew, DT3
Balakrishnan, V1
Becker, M1
Löhrke, S1
Nothwang, HG1
Güresir, E1
Friauf, E2
Jones, BW1
Watt, CB1
Frederick, JM1
Baehr, W1
Chen, CK1
Levine, EM1
Milam, AH1
Lavail, MM1
Marc, RE1
Vitellaro-Zuccarello, L1
Calvaresi, N1
De Biasi, S1
Hsu, YH1
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Parker, I1
Miledi, R2
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Morio, Y1
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Terwilleger, ER1
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Dziki, M1
Parada, J1
Kleinrok, Z1
Cavalheiro, EA1
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Clinical Trials (8)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Role of the Gut Microbiome as Determinant of Depression in Multiple Sclerosis Subjects[NCT05808101]120 participants (Anticipated)Observational2022-01-27Recruiting
Structural and Functional Imaging of Neuropsychiatric Patients and Normal Volunteers With 3.0 Tesla MRI and Magnetoencephalography (MEG)[NCT00004571]3,420 participants (Anticipated)Observational2000-02-17Recruiting
A Neurobiological Investigation of Patients With Schizophrenia Spectrum Disorders and Their Siblings[NCT00001486]6,150 participants (Anticipated)Observational1995-07-15Recruiting
GHRH: Cognition in Aging and MCI[NCT00257712]Phase 2151 participants (Actual)Interventional2006-02-28Completed
Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776]Phase 254 participants (Actual)Interventional2017-08-07Completed
Clinical Trial of Etanercept (TNF-α Blocker) for Treatment of Blast-Induced Tinnitus[NCT04066348]Phase 2310 participants (Anticipated)Interventional2022-07-01Recruiting
A Multicentre, Double-blind, Randomized, Phase IV Clinical Trial Comparing the Safety, Tolerability and Efficacy of Levetiracetam Versus Lamotrigine and Carbamazepine in the Oral Antiepileptic Therapy of Newly Diagnosed Elderly Patients With Focal Epileps[NCT00438451]Phase 4361 participants (Actual)Interventional2007-01-31Completed
The Efficacy of ACupuncture On Menopausal Symptoms (ACOM): A Randomized Controlled Trial[NCT02746497]70 participants (Actual)Interventional2016-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Prefrontal GABA+ Concentrations

Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition

Interventionmmol/kg (Mean)
N-Acetylcysteine3.90
Gabapentin3.93
Placebo Oral Tablet3.73

Prefrontal Glx Concentrations

Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition

Interventionmmol/kg (Mean)
N-Acetylcysteine21.59
Gabapentin21.69
Placebo Oral Tablet22.25

58-week Retention Rate Measured by the Number of Drop Outs Due to Adverse Events or Seizures From Day 1 of Treatment

(NCT00438451)
Timeframe: 58 weeks

Interventionproportion of participants (Mean)
Levetiracetam0.61
Carbamazepine0.46
Lamotrigine0.56

Percentage of Patients Remaining Seizure Free at Week 58 (Visit 6)

Percentage of patients experiencing no seizures until week 58 (Visit 6) and did not discontinue the study until week 58. (NCT00438451)
Timeframe: week 58

Interventionpercentage of participants (Number)
Levetiracetam43
Carbamazepine33
Lamotrigine38

Percentage of Patients Remaining Seizure-free at Week 30 (Visit 4)

Percentage of patients experiencing no seizures until week 30 (Visit 4) and did not discontinue the study until week 30. (NCT00438451)
Timeframe: Week 30

Interventionpercentage of participants (Number)
Levetiracetam48
Carbamazepine39
Lamotrigine49

Proportion of Seizure-free Days During the Maintenance Phase for Subjects Who Enter the Maintenance Phase

(NCT00438451)
Timeframe: 52 weeks

Interventionproportion of seizure-free days (Number)
Levetiracetam0.99
Carbamazepine0.99
Lamotrigine0.99

Results of Cognitive Testing (EpiTrack© by UCB) - Score at V6

EPITrack-Score shows the performance of attention and executive functions. Higher values indicate a better performance. The results of EPITrack Score ranges between 7 and 45. (NCT00438451)
Timeframe: week 58

Interventionunits on a scale (Mean)
Levetiracetam26.0
Carbamazepine26.0
Lamotrigine25.4

The Absolute Seizure Frequency During the Maintenance Phase (Weeks 7 - 58)

"Seizure frequency was assessed by investigators in the CRF at the Visits V3, V4, V5 and V6.~The absolute seizure frequency during the maintenance phase was defined as the sum of those entries." (NCT00438451)
Timeframe: over 52 weeks

Interventionnumber of seizures (Number)
Levetiracetam168
Carbamazepine131
Lamotrigine130

The Time (in Days) to First Break-through Seizure (From Day 1 of Treatment)

(NCT00438451)
Timeframe: over the whole duration of 58 weeks

Interventiondays (Median)
LevetiracetamNA
CarbamazepineNA
LamotrigineNA

Time to Drop Out

number of days between randomization and premature discontinuation of the study (NCT00438451)
Timeframe: 58 weeks

Interventiondays (Median)
LevetiracetamNA
Carbamazepine265
LamotrigineNA

Portland Neurotoxicity Scale (PNS) at V6

"The PNS is a 15-item scale. Each item can be scored from 1 to 9. There are a total score (includes all items, range:15 to 135) and two subscores: The cognitive toxicity subscore (10 items: Energy Level, Memory, Interest, Concentration, Forgetfulness, Sleepliness, Moodiness, Alertness, Attention Span, Motivation, range:10 to 90) and the somatomoto subscore (5 items: Vision, Walking, Coordination, Tremor, Speech, range:5-45). The score is calculated by taking the mean of all non-missing values times the number of items.~Lower values indicate better quality of life." (NCT00438451)
Timeframe: at week 58

,,
Interventionunits on a scale (Mean)
Cognitive toxicity subscoreSomatomotor subscoreTotal Score
Carbamazepine27.311.438.7
Lamotrigine23.710.834.5
Levetiracetam22.210.532.7

QOLIE-31 (Quality Of Life In Epilepsy) Results at V6

The QOLIE-31 is a 31 item score that measures the quality of life in epilepsy (each item with a range of 0 to 100). There are 7 sub-scores seizure worry (items 11,21,22,23,25), overall quality of life (items 1,14), emotional well-being (items 3,4,5,7,9), energy/fatigue (items 2,6,8,10), cognitive functioning (items 12,15,16,17,18,26), medication effects (items 24,29,30) and social functioning (13,19,20,27,28). These scores were combined to a total score by Total score = seizure worry*0.08 + overall quality of life*0.14 + emotional well-being*0.15 + energy/fatigue*0.12 + cognitive functioning*0.27 + medication effects*0.03 + social functioning*0.21 For all scores, higher values indicate better quality of life. Each score has a possible range from 0 to 100. (NCT00438451)
Timeframe: 58 weeks, final visit

,,
Interventionunits on a scale (Mean)
Seizure worryOverall quality of lifeEmotional well-beingEnergy/fatigueCognitive functioningMedication effectsSocial functioningTotal ScoreHealth Scale
Carbamazepine75.465.069.854.568.970.676.368.965.7
Lamotrigine75.067.167.459.868.072.676.769.167.5
Levetiracetam85.167.272.060.875.177.681.173.969.5

Results of Cognitive Testing (EpiTrack© by UCB) - Categories at V6

"Evaluation of current testing at V6:~≥29 score points: Inconspicuous; 26 to 28 score points: Borderline;~≤25 score points: Impaired" (NCT00438451)
Timeframe: 58 weeks

,,
Interventionparticipants (Number)
Without pathological findingsBorderlineImpaired
Carbamazepine341733
Lamotrigine311539
Levetiracetam381036

Results of Cognitive Testing (EpiTrack© by UCB) - Changes to Baseline (V0) at Week 58 (V6)

"Evaluation of Changes~Changes in the EpiTrack® Score were categorized as follows:~≥5 score points: Improved;~-3 to 4 score points: Unchanged;~≤-4 score points: Worsened" (NCT00438451)
Timeframe: week 58

,,
Interventionparticipants (Number)
ImprovedUnchangedWorsened
Carbamazepine16568
Lamotrigine155313
Levetiracetam15616

Reviews

50 reviews available for gamma-aminobutyric acid and Aging

ArticleYear
Response inhibition in humans: a whistle stop review.
    Journal of neurophysiology, 2020, 03-01, Volume: 123, Issue:3

    Topics: Aging; gamma-Aminobutyric Acid; Humans; Inhibition, Psychological; Nerve Net; Transcranial Magnetic

2020
Mechanisms of GABAergic and cholinergic neurotransmission in auditory thalamus: Impact of aging.
    Hearing research, 2021, 03-15, Volume: 402

    Topics: Acoustic Stimulation; Aged; Aging; Cholinergic Agents; gamma-Aminobutyric Acid; Geniculate Bodies; H

2021
The trajectory of cortical GABA across the lifespan, an individual participant data meta-analysis of edited MRS studies.
    eLife, 2021, 06-01, Volume: 10

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Bayes Theorem; Cerebral Cortex; Chil

2021
The space where aging acts: focus on the GABAergic synapse.
    Aging cell, 2017, Volume: 16, Issue:4

    Topics: Aging; Animals; Calbindin 2; Calbindins; Cell Count; Cognitive Dysfunction; GABAergic Neurons; gamma

2017
The Dynamics of Neurosteroids and Sex-Related Hormones in the Pathogenesis of Alzheimer's Disease.
    Neuromolecular medicine, 2018, Volume: 20, Issue:2

    Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Brain; Cell Differentiation; Di

2018
Molecular aspects of age-related cognitive decline: the role of GABA signaling.
    Trends in molecular medicine, 2015, Volume: 21, Issue:7

    Topics: Aging; Cognition; gamma-Aminobutyric Acid; Humans; Prefrontal Cortex; Receptors, GABA; Signal Transd

2015
Vasomotor symptoms: viewpoint from the Indian subcontinent and management of a common menopausal problem.
    Seminars in reproductive medicine, 2010, Volume: 28, Issue:5

    Topics: Aging; Amines; Antihypertensive Agents; Asian People; Complementary Therapies; Cyclohexanecarboxylic

2010
Altered GABA signaling in early life epilepsies.
    Neural plasticity, 2011, Volume: 2011

    Topics: Aging; Child, Preschool; Epilepsy; Female; gamma-Aminobutyric Acid; Humans; Infant; Infant, Newborn;

2011
The interesting interplay between interneurons and adult hippocampal neurogenesis.
    Molecular neurobiology, 2011, Volume: 44, Issue:3

    Topics: Aging; Animals; gamma-Aminobutyric Acid; Hippocampus; Humans; Interneurons; Mental Disorders; Nervou

2011
[Neurological consequences after long-term sedation in the ICU].
    Annales francaises d'anesthesie et de reanimation, 2012, Volume: 31, Issue:1

    Topics: Aging; Anesthetics, General; Animals; Cesarean Section; Conscious Sedation; Critical Care; Excitator

2012
GABA through the ages: regulation of cortical function and plasticity by inhibitory interneurons.
    Neural plasticity, 2012, Volume: 2012

    Topics: Aging; Animals; Cell Movement; Cerebral Cortex; gamma-Aminobutyric Acid; Humans; Interneurons; Mice;

2012
Steroid modulation of astrocytes in the neonatal brain: implications for adult reproductive function.
    Biology of reproduction, 2002, Volume: 67, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Astrocytes; Brain; Cell Differentiation; Estradiol; Female; gamma-

2002
Assessment and treatment of hot flushes and menopausal mood disturbance.
    The Psychiatric clinics of North America, 2003, Volume: 26, Issue:3

    Topics: Acetates; Aging; Amines; Anti-Anxiety Agents; Cognition Disorders; Cyclohexanecarboxylic Acids; Fema

2003
[Dementia induced by antianxiety drugs].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl

    Topics: Aging; Anti-Anxiety Agents; Benzodiazepines; Chlorides; Dementia; GABA-A Receptor Agonists; gamma-Am

2004
Antiaging treatments have been legally prescribed for approximately thirty years.
    Annals of the New York Academy of Sciences, 2004, Volume: 1019

    Topics: Aging; Brain; Cognition; Drug Prescriptions; gamma-Aminobutyric Acid; Humans; Longevity; Oxygen

2004
Role of synaptic inhibition in spatiotemporal patterning of cortical activity.
    Progress in brain research, 2005, Volume: 147

    Topics: Aging; Animals; Electrophysiology; gamma-Aminobutyric Acid; Nerve Net; Neural Inhibition; Protein Is

2005
Motion perception getting better with age?
    Neuron, 2005, Feb-03, Volume: 45, Issue:3

    Topics: Aged; Aging; Contrast Sensitivity; gamma-Aminobutyric Acid; Humans; Motion Perception; Neural Inhibi

2005
[Epilepsy in the elderly].
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2007, Volume: 27, Issue:1

    Topics: Aged; Aged, 80 and over; Aging; Amines; Anticonvulsants; Cerebrovascular Disorders; Comorbidity; Cyc

2007
Changes in the structural complexity of the aged brain.
    Aging cell, 2007, Volume: 6, Issue:3

    Topics: Action Potentials; Aged; Aging; Alzheimer Disease; Brain; Dendrites; Dendritic Spines; Electrophysio

2007
GABA(A) receptors in aging and Alzheimer's disease.
    Journal of neurochemistry, 2007, Volume: 103, Issue:4

    Topics: Aging; Alzheimer Disease; Animals; gamma-Aminobutyric Acid; Humans; Protein Subunits; Receptors, GAB

2007
Glutamate-dopamine-GABA interactions in the aging basal ganglia.
    Brain research reviews, 2008, Volume: 58, Issue:2

    Topics: Age Factors; Aging; Animals; Basal Ganglia; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Humans

2008
Uncovering the mechanisms of estrogen effects on hippocampal function.
    Frontiers in neuroendocrinology, 2008, Volume: 29, Issue:2

    Topics: Acetylcholine; Aging; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cognition; Cyclic

2008
Menopause.
    Lancet (London, England), 2008, Mar-01, Volume: 371, Issue:9614

    Topics: Adult; Aging; Amines; Cyclohexanecarboxylic Acids; Estrogen Replacement Therapy; Female; Gabapentin;

2008
Central neurotransmitters and aging.
    Life sciences, 1980, May-19, Volume: 26, Issue:20

    Topics: Acetylcholine; Adenylyl Cyclases; Adult; Aged; Aging; Animals; Aromatic-L-Amino-Acid Decarboxylases;

1980
Neurobiology of aging.
    New York state journal of medicine, 1981, Volume: 81, Issue:6

    Topics: Aging; Brain; Brain Chemistry; Cell Survival; Dopamine; gamma-Aminobutyric Acid; Humans; Lipofuscin;

1981
Neuroendocrine control of thyrotropin secretion.
    Endocrine reviews, 1981,Fall, Volume: 2, Issue:4

    Topics: Adult; Aging; Animals; Calcium; Cholecystokinin; Circadian Rhythm; Cyclic AMP; Dopamine; Estrogens;

1981
Neurotransmitter systems in aging and senile dementia.
    Progress in neuro-psychopharmacology, 1981, Volume: 5, Issue:5-6

    Topics: Acetylcholine; Aged; Aging; Animals; Brain; Choline; Clinical Trials as Topic; Dementia; Dopamine; g

1981
Biochemical changes in normal aging in human brain.
    Advances in neurology, 1983, Volume: 38

    Topics: Acetylcholinesterase; Adaptation, Physiological; Adenosylmethionine Decarboxylase; Adult; Aged; Agin

1983
[Neuromediators in the brain of the aged].
    Presse medicale (Paris, France : 1983), 1983, Dec-29, Volume: 12, Issue:48

    Topics: Acetylcholine; Aged; Aging; Animals; Autopsy; Brain; Catecholamines; Endorphins; gamma-Aminobutyric

1983
GABA binding processes and behavior.
    General pharmacology, 1983, Volume: 14, Issue:3

    Topics: Aging; Animals; Basal Ganglia Diseases; Behavior; Behavior, Animal; Epilepsy; Extrapyramidal Tracts;

1983
Trophic actions of GABA on the development of physiologically active GABA receptors.
    Advances in biochemical psychopharmacology, 1983, Volume: 37

    Topics: Aging; Animals; Aspartic Acid; Cells, Cultured; Cerebellum; gamma-Aminobutyric Acid; Glutamates; Hum

1983
Benzodiazepine receptors.
    Neuropharmacology, 1984, Volume: 23, Issue:2B

    Topics: Aging; Animals; Cells; gamma-Aminobutyric Acid; Humans; Receptors, Cell Surface; Receptors, Drug; Re

1984
Cerebrospinal fluid GABA measurements: basic and clinical considerations.
    Clinical neuropharmacology, 1983, Volume: 6, Issue:1

    Topics: Aging; Diet; Female; gamma-Aminobutyric Acid; Humans; Male; Sex Factors

1983
On some conditions that influence cortical spreading depression.
    Anais da Academia Brasileira de Ciencias, 1984, Volume: 56, Issue:4

    Topics: Aging; Animals; Chlorides; Cortical Spreading Depression; Electroencephalography; gamma-Aminobutyric

1984
Chemical pathology of Huntington's disease.
    Annual review of pharmacology and toxicology, 1980, Volume: 20

    Topics: Acetylcholine; Aging; Behavior; Dopamine; gamma-Aminobutyric Acid; Humans; Huntington Disease; Neuro

1980
Alterations of central GABAergic activity in neurologic and psychiatric disorders: evaluation through measurements of GABA and GAD activity in cerebrospinal fluid.
    Molecular and cellular biochemistry, 1981, Sep-25, Volume: 39

    Topics: Aging; Carboxy-Lyases; Cold Temperature; Drug Stability; Female; gamma-Aminobutyric Acid; Glutamate

1981
Biosynthesis and assay of neurosteroids in rats and mice: functional correlates.
    The Journal of steroid biochemistry and molecular biology, 1995, Volume: 53, Issue:1-6

    Topics: Adrenalectomy; Aggression; Aging; Animals; Behavior, Animal; Dehydroepiandrosterone; Dihydrotestoste

1995
Basic aspects of GABA-transaminase in neuropsychiatric disorders.
    Clinical biochemistry, 1995, Volume: 28, Issue:2

    Topics: 4-Aminobutyrate Transaminase; Aging; Animals; Blood Platelets; Brain; Brain Diseases; Female; gamma-

1995
[Sodium valproate--still a current antiepileptic agent?].
    Praxis, 1994, Oct-04, Volume: 83, Issue:40

    Topics: Aging; Drug Interactions; Electroencephalography; Female; gamma-Aminobutyric Acid; Humans; Milk, Hum

1994
Central tinnitus and lateral inhibition: an auditory brainstem model.
    Hearing research, 1996, Volume: 97, Issue:1-2

    Topics: Acoustic Stimulation; Aging; Animals; Auditory Threshold; Cats; Cochlear Nucleus; Disease Models, An

1996
Excitatory neurotransmission and sexual differentiation of the brain.
    Brain research bulletin, 1997, Volume: 44, Issue:4

    Topics: Aging; Animals; Brain; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Male

1997
GABAergic deafferentation hypothesis of brain aging and Alzheimer's disease revisited.
    Brain research bulletin, 1998, Volume: 45, Issue:4

    Topics: Aging; Alzheimer Disease; Animals; Brain; gamma-Aminobutyric Acid; Humans; Neurons, Afferent; Recept

1998
Neural mechanisms underlying the pubertal increase in LHRH release in the rhesus monkey.
    Trends in endocrinology and metabolism: TEM, 2001, Volume: 12, Issue:8

    Topics: Aging; Animals; Brain; Female; gamma-Aminobutyric Acid; Glutamic Acid; Gonadotropin-Releasing Hormon

2001
Audiogenic seizures in mice.
    Federation proceedings, 1979, Volume: 38, Issue:10

    Topics: Acoustic Stimulation; Aging; Animals; Cerebellum; gamma-Aminobutyric Acid; Mice; Mice, Inbred A; Mic

1979
Potassium effects on transport of amino acids, inorganic ions, and water: ontogenetic and quantitative differences.
    Advances in experimental medicine and biology, 1976, Volume: 69

    Topics: Adenosine Triphosphatases; Aging; Amino Acids; Animals; Biological Transport, Active; Brain; Chick E

1976
GABA-receptors in the vertebrate nervous system.
    Progress in neurobiology, 1977, Volume: 9, Issue:3

    Topics: Action Potentials; Aging; Aminobutyrates; Animals; Bicuculline; Brain; Cats; Cerebellar Cortex; Cere

1977
The role of afferent activity in the maintenance of primate neocorticalfunction.
    The Journal of experimental biology, 1990, Volume: 153

    Topics: Afferent Pathways; Aging; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cerebral Cortex; ga

1990
Benzodiazepines and the developing rat: a critical review.
    Neuroscience and biobehavioral reviews, 1985,Spring, Volume: 9, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Brain; Bra

1985
Dopamine: a prolactin-inhibiting hormone.
    Endocrine reviews, 1985,Fall, Volume: 6, Issue:4

    Topics: Aging; Animals; Cyclic AMP; Dopamine; Electrophysiology; Female; gamma-Aminobutyric Acid; Gonadotrop

1985
[Pathophysiology of dementia].
    No to shinkei = Brain and nerve, 1985, Volume: 37, Issue:10

    Topics: Acetylcholine; Aged; Aging; Alzheimer Disease; Brain; Brain Chemistry; Dementia; Dopamine; gamma-Ami

1985

Trials

9 trials available for gamma-aminobutyric acid and Aging

ArticleYear
Growth hormone-releasing hormone effects on brain γ-aminobutyric acid levels in mild cognitive impairment and healthy aging.
    JAMA neurology, 2013, Volume: 70, Issue:7

    Topics: Aged; Aged, 80 and over; Aging; Brain Chemistry; Cognitive Dysfunction; Double-Blind Method; Female;

2013
Exposure-response analyses of the effects of pregabalin in patients with fibromyalgia using daily pain scores and patient global impression of change.
    Journal of clinical pharmacology, 2010, Volume: 50, Issue:7

    Topics: Adult; Aging; Algorithms; Analgesics; Creatinine; Data Interpretation, Statistical; Dose-Response Re

2010
[Biological age and the pain syndrome at diabetic polyneuropathy].
    Advances in gerontology = Uspekhi gerontologii, 2011, Volume: 24, Issue:2

    Topics: Adult; Aging; Amines; Calcium Channel Blockers; Cyclohexanecarboxylic Acids; Diabetic Neuropathies;

2011
New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine.
    Neurology, 2005, Jun-14, Volume: 64, Issue:11

    Topics: Aged; Aging; Amines; Anticonvulsants; Carbamazepine; Cerebral Infarction; Cyclohexanecarboxylic Acid

2005
Serum concentrations of pregabalin in patients with epilepsy: the influence of dose, age, and comedication.
    Therapeutic drug monitoring, 2007, Volume: 29, Issue:6

    Topics: Adult; Aged; Aging; Anticonvulsants; Dose-Response Relationship, Drug; Drug Interactions; Drug Monit

2007
Neurotransmitter systems in aging and senile dementia.
    Progress in neuro-psychopharmacology, 1981, Volume: 5, Issue:5-6

    Topics: Acetylcholine; Aged; Aging; Animals; Brain; Choline; Clinical Trials as Topic; Dementia; Dopamine; g

1981
Aging alters regional multichemical profile of the human brain: an in vivo 1H-MRS study of young versus middle-aged subjects.
    Journal of neurochemistry, 2001, Volume: 76, Issue:2

    Topics: Adult; Age Factors; Aging; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female; gamma-A

2001
Aging alters the multichemical networking profile of the human brain: an in vivo (1)H-MRS study of young versus middle-aged subjects.
    Journal of neurochemistry, 2001, Volume: 77, Issue:1

    Topics: Adult; Aging; Analysis of Variance; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female

2001
Impaired growth hormone response to sodium valproate in normal aging.
    Psychopharmacology, 1987, Volume: 91, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aging; gamma-Aminobutyric Acid; Growth Hormone; Humans; Hypothalamo-

1987

Other Studies

639 other studies available for gamma-aminobutyric acid and Aging

ArticleYear
Changes in Locomotor Activity and Oxidative Stress-Related Factors after the Administration of an Amino Acid Mixture by Generation and Age.
    International journal of molecular sciences, 2021, Sep-10, Volume: 22, Issue:18

    Topics: 5-Hydroxytryptophan; Aging; Amino Acids; Animals; Central Nervous System; Disease Models, Animal; ga

2021
Relationships between frontal metabolites and Alzheimer's disease biomarkers in cognitively normal older adults.
    Neurobiology of aging, 2022, Volume: 109

    Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Biomarkers; Cognition; Creatine; Fem

2022
Age-related decline in cortical inhibitory tone strengthens motor memory.
    NeuroImage, 2021, 12-15, Volume: 245

    Topics: Adaptation, Physiological; Aged; Aged, 80 and over; Aging; Evoked Potentials, Motor; gamma-Aminobuty

2021
Task-Related Modulation of Sensorimotor GABA+ Levels in Association with Brain Activity and Motor Performance: A Multimodal MRS-fMRI Study in Young and Older Adults.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022, 02-09, Volume: 42, Issue:6

    Topics: Adult; Aged; Aging; Female; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Imaging; Magnetic Re

2022
Region-Specific and Age-Dependent Multitarget Effects of Acetylcholinesterase Inhibitor Tacrine on Comprehensive Neurotransmitter Systems.
    ACS chemical biology, 2022, 01-21, Volume: 17, Issue:1

    Topics: Aging; Animals; Brain; Brain Mapping; Cholinesterase Inhibitors; Dopaminergic Neurons; gamma-Aminobu

2022
Exogenous GABA improves the antioxidant and anti-aging ability of silkworm (Bombyx mori).
    Food chemistry, 2022, Jul-30, Volume: 383

    Topics: Aging; Animals; Antioxidants; Bombyx; gamma-Aminobutyric Acid; Larva; RNA, Messenger

2022
The glutamate/GABA system in the retina of male rats: effects of aging, neurodegeneration, and supplementation with melatonin and antioxidant SkQ1.
    Biogerontology, 2022, Volume: 23, Issue:5

    Topics: Aging; Aminobutyrates; Animals; Antioxidants; Dietary Supplements; Disease Models, Animal; gamma-Ami

2022
Age-related ultrastructural changes in the lateral cortex of the inferior colliculus.
    Neurobiology of aging, 2022, Volume: 120

    Topics: Aging; Animals; Cerebral Cortex; gamma-Aminobutyric Acid; Inferior Colliculi; Rats; Synapses

2022
Follicle-Stimulating Hormone Alleviates Ovarian Aging by Modulating Mitophagy- and Glycophagy-Based Energy Metabolism in Hens.
    Cells, 2022, 10-18, Volume: 11, Issue:20

    Topics: Aging; AMP-Activated Protein Kinases; Animals; Chickens; Energy Metabolism; Female; Follicle Stimula

2022
GABA signaling triggered by TMC-1/Tmc delays neuronal aging by inhibiting the PKC pathway in
    Science advances, 2022, 12-21, Volume: 8, Issue:51

    Topics: Aged; Aging; Animals; Caenorhabditis elegans; gamma-Aminobutyric Acid; Humans; Ion Channels; Proteom

2022
γ-Aminobutyric acids (GABA) and serum GABA/AABA (G/A) ratio as potential biomarkers of physical performance and aging.
    Scientific reports, 2023, 10-10, Volume: 13, Issue:1

    Topics: Aged; Aging; Aminobutyrates; Biomarkers; Female; gamma-Aminobutyric Acid; Humans; Male; Physical Fun

2023
Beneficial effect of GABA-rich fermented milk whey on nervous system and intestinal microenvironment of aging mice induced by D-galactose.
    Microbiological research, 2024, Volume: 278

    Topics: Aging; Animals; Antioxidants; Brain; Galactose; gamma-Aminobutyric Acid; Mice; Milk; Oxidative Stres

2024
Glutamate, GABA, and Presynaptic Markers Involved in Neurotransmission Are Differently Affected by Age in Distinct Mouse Brain Regions.
    ACS chemical neuroscience, 2019, 11-20, Volume: 10, Issue:11

    Topics: Aging; Animals; Biomarkers; Blotting, Western; Brain; Brain Chemistry; Female; gamma-Aminobutyric Ac

2019
Distinct gradients of various neurotransmitter markers in caudate nucleus and putamen of the human brain.
    Journal of neurochemistry, 2020, Volume: 152, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Aging; Biomarkers; Caudate Nucleus; Choline O-Acetyltransferase; Dop

2020
Maturation of PNN and ErbB4 Signaling in Area CA2 during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory.
    Cell reports, 2019, Oct-29, Volume: 29, Issue:5

    Topics: Aging; Animals; Animals, Newborn; CA2 Region, Hippocampal; gamma-Aminobutyric Acid; Interneurons; Lo

2019
Adolescent forced swim stress increases social anxiety-like behaviors and alters kappa opioid receptor function in the basolateral amygdala of male rats.
    Progress in neuro-psychopharmacology & biological psychiatry, 2020, 03-02, Volume: 98

    Topics: Aging; Animals; Anxiety; Basolateral Nuclear Complex; Dynorphins; Female; gamma-Aminobutyric Acid; M

2020
Moderate maternal separation mitigates the altered synaptic transmission and neuronal activation in amygdala by chronic stress in adult mice.
    Molecular brain, 2019, 12-18, Volume: 12, Issue:1

    Topics: Aging; Amygdala; Animals; Anxiety; Behavior, Animal; Chronic Disease; Excitatory Postsynaptic Potent

2019
Activity-Dependent Plasticity of Axo-axonic Synapses at the Axon Initial Segment.
    Neuron, 2020, 04-22, Volume: 106, Issue:2

    Topics: Aging; Animals; Axon Initial Segment; Axons; gamma-Aminobutyric Acid; Interneurons; Mice; Mice, Tran

2020
Significance of inhibitory recruitment in aging with preserved cognition: limiting gamma-aminobutyric acid type A α5 function produces memory impairment.
    Neurobiology of aging, 2020, Volume: 91

    Topics: Aging; Animals; Cognitive Reserve; gamma-Aminobutyric Acid; Hippocampus; Male; Memory Disorders; Neu

2020
Calorie restriction improves aging-induced impairment of cognitive function in relation to deregulation of corticosterone status and brain regional GABA system.
    Mechanisms of ageing and development, 2020, Volume: 189

    Topics: Aging; Animals; Brain; Caloric Restriction; Cognition; Cognitive Dysfunction; Corticosterone; gamma-

2020
Baseline sensorimotor GABA levels shape neuroplastic processes induced by motor learning in older adults.
    Human brain mapping, 2020, Volume: 41, Issue:13

    Topics: Aged; Aging; Connectome; Female; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Imaging; Magnet

2020
Total GABA level in human auditory cortex is associated with speech-in-noise understanding in older age.
    NeuroImage, 2021, 01-15, Volume: 225

    Topics: Acoustic Stimulation; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Auditory Cortex; Auditory

2021
The maturational characteristics of the GABA input in the anterior piriform cortex may also contribute to the rapid learning of the maternal odor during the sensitive period.
    Learning & memory (Cold Spring Harbor, N.Y.), 2020, Volume: 27, Issue:12

    Topics: Aging; Animals; Animals, Newborn; Female; gamma-Aminobutyric Acid; Learning; Male; Models, Neurologi

2020
GABA levels are differentially associated with bimanual motor performance in older as compared to young adults.
    NeuroImage, 2021, 05-01, Volume: 231

    Topics: Adult; Aged; Aging; Brain; Female; Functional Laterality; gamma-Aminobutyric Acid; Humans; Magnetic

2021
GABA levels in ventral visual cortex decline with age and are associated with neural distinctiveness.
    Neurobiology of aging, 2021, Volume: 102

    Topics: Aging; Animals; Cell Dedifferentiation; Cognition; gamma-Aminobutyric Acid; Humans; Magnetic Resonan

2021
Neonatal programming with sex hormones: Effect on expression of dopamine D
    European journal of pharmacology, 2021, Jul-05, Volume: 902

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Animals, Newborn; Dopami

2021
GABA and primary motor cortex inhibition in young and older adults: a multimodal reliability study.
    Journal of neurophysiology, 2017, 07-01, Volume: 118, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aging; Electromyography; Evoked Potentials, Motor; Female; gamma-Ami

2017
Normal Aging Slows Spontaneous Switching in Auditory and Visual Bistability.
    Neuroscience, 2018, 10-01, Volume: 389

    Topics: Acoustic Stimulation; Adult; Aging; Auditory Perception; Brain; Female; gamma-Aminobutyric Acid; Hum

2018
Amino acid and acetylcholine chemistry in the central auditory system of young, middle-aged and old rats.
    Hearing research, 2017, Volume: 350

    Topics: Acetylcholine; Age Factors; Aging; Amino Acids; Animals; Aspartic Acid; Auditory Pathways; Brain; Ch

2017
Increasing GABA reverses age-related alterations in excitatory receptive fields and intensity coding of auditory midbrain neurons in aged mice.
    Neurobiology of aging, 2017, Volume: 56

    Topics: 4-Aminobutyrate Transaminase; Acoustic Stimulation; Aging; Animals; Anticonvulsants; Auditory Percep

2017
Impact of tissue correction strategy on GABA-edited MRS findings.
    NeuroImage, 2017, 11-15, Volume: 162

    Topics: Adult; Aged; Aged, 80 and over; Aging; Female; Frontal Lobe; gamma-Aminobutyric Acid; Humans; Image

2017
Magnesium Sulfate Prevents Neurochemical and Long-Term Behavioral Consequences of Neonatal Excitotoxic Lesions: Comparison Between Male and Female Mice.
    Journal of neuropathology and experimental neurology, 2017, Oct-01, Volume: 76, Issue:10

    Topics: Aging; Animals; Animals, Newborn; Brain; Calcium Channel Blockers; Disease Models, Animal; Excitator

2017
The anti-aging protein Klotho is induced by GABA therapy and exerts protective and stimulatory effects on pancreatic beta cells.
    Biochemical and biophysical research communications, 2017, 12-02, Volume: 493, Issue:4

    Topics: Aging; Animals; Cell Proliferation; Cell Survival; Cells, Cultured; Diabetes Mellitus, Experimental;

2017
Long-Range GABAergic Inputs Regulate Neural Stem Cell Quiescence and Control Adult Hippocampal Neurogenesis.
    Cell stem cell, 2017, Nov-02, Volume: 21, Issue:5

    Topics: Aging; Animals; Cell Cycle; Dentate Gyrus; GABAergic Neurons; gamma-Aminobutyric Acid; Gene Deletion

2017
A bell-shaped dependence between amyloidosis and GABA accumulation in astrocytes in a mouse model of Alzheimer's disease.
    Neurobiology of aging, 2018, Volume: 61

    Topics: Aging; Alzheimer Disease; Amyloidogenic Proteins; Amyloidosis; Animals; Astrocytes; Brain; Disease M

2018
Resveratrol modulates cocaine-induced inhibitory synaptic plasticity in VTA dopamine neurons by inhibiting phosphodiesterases (PDEs).
    Scientific reports, 2017, Nov-15, Volume: 7, Issue:1

    Topics: Aging; Animals; Cocaine; Cocaine-Related Disorders; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases

2017
Sex- and age-specific modulation of brain GABA levels in a mouse model of Alzheimer's disease.
    Neurobiology of aging, 2018, Volume: 62

    Topics: Aging; Alzheimer Disease; Amyloidogenic Proteins; Animals; Astrocytes; Brain; Disease Models, Animal

2018
Notable advances 2017.
    Nature medicine, 2017, 12-07, Volume: 23, Issue:12

    Topics: Aging; Biomedical Research; Cancer Vaccines; Cardiovascular Diseases; Diabetes Mellitus, Type 1; gam

2017
The neurochemical basis of the contextual interference effect.
    Neurobiology of aging, 2018, Volume: 66

    Topics: Adolescent; Adult; Aged; Aging; Female; gamma-Aminobutyric Acid; Humans; Learning; Magnetic Resonanc

2018
Age-related differences in GABA levels are driven by bulk tissue changes.
    Human brain mapping, 2018, Volume: 39, Issue:9

    Topics: Adolescent; Adult; Aged; Aging; Brain Chemistry; Cerebrospinal Fluid; Female; gamma-Aminobutyric Aci

2018
Aging and GABA.
    Aging, 2018, Jun-13, Volume: 10, Issue:6

    Topics: Aging; Brain; Cognition; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Spectroscopy; Transcran

2018
Effects of chronic noise exposure on the microbiome-gut-brain axis in senescence-accelerated prone mice: implications for Alzheimer's disease.
    Journal of neuroinflammation, 2018, Jun-22, Volume: 15, Issue:1

    Topics: Aging; Animals; Avoidance Learning; Brain; Claudins; Cognition Disorders; Corticosterone; Cytokines;

2018
Role of gamma-amino-butyric acid in the dorsal anterior cingulate in age-associated changes in cognition.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018, Volume: 43, Issue:11

    Topics: Adolescent; Adult; Aging; Cognition; Cognitive Dysfunction; Female; gamma-Aminobutyric Acid; Gyrus C

2018
Role of gamma-amino-butyric acid in the dorsal anterior cingulate in age-associated changes in cognition.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018, Volume: 43, Issue:11

    Topics: Adolescent; Adult; Aging; Cognition; Cognitive Dysfunction; Female; gamma-Aminobutyric Acid; Gyrus C

2018
Role of gamma-amino-butyric acid in the dorsal anterior cingulate in age-associated changes in cognition.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018, Volume: 43, Issue:11

    Topics: Adolescent; Adult; Aging; Cognition; Cognitive Dysfunction; Female; gamma-Aminobutyric Acid; Gyrus C

2018
Role of gamma-amino-butyric acid in the dorsal anterior cingulate in age-associated changes in cognition.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018, Volume: 43, Issue:11

    Topics: Adolescent; Adult; Aging; Cognition; Cognitive Dysfunction; Female; gamma-Aminobutyric Acid; Gyrus C

2018
Age-Related Declines in Occipital GABA are Associated with Reduced Fluid Processing Ability.
    Academic radiology, 2019, Volume: 26, Issue:8

    Topics: Aged; Aging; Cognition; Female; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Spectroscopy; Ma

2019
Sensorimotor network segregation declines with age and is linked to GABA and to sensorimotor performance.
    NeuroImage, 2019, 02-01, Volume: 186

    Topics: Adult; Aged; Aged, 80 and over; Aging; Brain Mapping; Female; gamma-Aminobutyric Acid; Humans; Magne

2019
Effect of Antibodies to Glutamate on Age-Related Memory Changes in C57Bl/6 Mice.
    Bulletin of experimental biology and medicine, 2019, Volume: 166, Issue:3

    Topics: Administration, Intranasal; Aging; Animals; Antibodies; Aspartic Acid; Avoidance Learning; Condition

2019
Sex- and age-related changes in GABA signaling components in the human cortex.
    Biology of sex differences, 2019, 01-14, Volume: 10, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aging; Cerebral Cortex; Female; gamma-Aminobutyric Acid; Humans; Mal

2019
Age-related alterations in the modulation of intracortical inhibition during stopping of actions.
    Aging, 2019, 01-22, Volume: 11, Issue:2

    Topics: Adult; Aged; Aging; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Motor Cortex; Muscle

2019
Morphological and neurochemical changes in GABAergic neurons of the aging human inferior colliculus.
    Hearing research, 2019, Volume: 377

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Auditory Pathways; Cell Death; Child

2019
GABA and glutamate moderate beta-amyloid related functional connectivity in cognitively unimpaired old-aged adults.
    NeuroImage. Clinical, 2019, Volume: 22

    Topics: Aged; Aging; Amyloid beta-Peptides; Aniline Compounds; Cerebellum; Cerebral Cortex; Connectome; Fema

2019
Age-Dependency of Levetiracetam Effects on Exocytotic GABA Release from Nerve Terminals in the Hippocampus and Cortex in Norm and After Perinatal Hypoxia.
    Cellular and molecular neurobiology, 2019, Volume: 39, Issue:5

    Topics: Aging; Animals; Animals, Newborn; Exocytosis; gamma-Aminobutyric Acid; Hippocampus; Hypoxia; Levetir

2019
GABAergic and glutamatergic cells in the inferior colliculus dynamically express the GABA
    Neurobiology of aging, 2019, Volume: 80

    Topics: Aging; Animals; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Inferior Colliculi; Rats; Receptor

2019
Adolescent stress increases depression-like behaviors and alters the excitatory-inhibitory balance in aged mice.
    Chinese medical journal, 2019, Jul-20, Volume: 132, Issue:14

    Topics: Aging; Animals; Anxiety; Brain; Depression; Depressive Disorder; gamma-Aminobutyric Acid; Hippocampu

2019
Neural distinctiveness declines with age in auditory cortex and is associated with auditory GABA levels.
    NeuroImage, 2019, 11-01, Volume: 201

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Auditory Cortex; Cross-Sectional Stu

2019
Ambient GABA responsible for age-related changes in multistable perception.
    Neural computation, 2013, Volume: 25, Issue:5

    Topics: Aging; gamma-Aminobutyric Acid; Humans; Models, Neurological; Neural Networks, Computer; Optical Ill

2013
Edited magnetic resonance spectroscopy detects an age-related decline in brain GABA levels.
    NeuroImage, 2013, Volume: 78

    Topics: Adult; Aged; Aging; Brain; Brain Chemistry; Female; gamma-Aminobutyric Acid; Humans; Magnetic Resona

2013
Altered synapses and gliotransmission in Alzheimer's disease and AD model mice.
    Neurobiology of aging, 2013, Volume: 34, Issue:10

    Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Cerebral Cortex; Disease Model

2013
GABAergic tonic inhibition is regulated by developmental age and epilepsy in the dentate gyrus.
    Neuroreport, 2013, Jul-10, Volume: 24, Issue:10

    Topics: Aging; Animals; Anticonvulsants; Data Interpretation, Statistical; Dentate Gyrus; Diazepam; Electrop

2013
Bumetanide, an inhibitor of cation-chloride cotransporter isoform 1, inhibits γ-aminobutyric acidergic excitatory actions and enhances sedative actions of midazolam in neonatal rats.
    Anesthesiology, 2013, Volume: 119, Issue:5

    Topics: Aging; Animals; Animals, Newborn; Bumetanide; CA3 Region, Hippocampal; Calcium; Calcium Signaling; C

2013
Functional aging in the nervous system contributes to age-dependent motor activity decline in C. elegans.
    Cell metabolism, 2013, Sep-03, Volume: 18, Issue:3

    Topics: Acetylcholine; Aging; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; gamma-Aminob

2013
Age-related changes in a patient with Pelizaeus-Merzbacher disease determined by repeated 1H-magnetic resonance spectroscopy.
    Journal of child neurology, 2014, Volume: 29, Issue:2

    Topics: Aging; Aspartic Acid; Case-Control Studies; Child, Preschool; Creatine; gamma-Aminobutyric Acid; Glu

2014
Chronic fluoxetine treatment reduces parvalbumin expression and perineuronal nets in gamma-aminobutyric acidergic interneurons of the frontal cortex in adult mice.
    Molecular brain, 2013, Nov-05, Volume: 6

    Topics: Aging; Animals; Apoptosis; CA3 Region, Hippocampal; Calbindin 2; Cell Count; Fluoxetine; Frontal Lob

2013
GAD67 deficiency in parvalbumin interneurons produces deficits in inhibitory transmission and network disinhibition in mouse prefrontal cortex.
    Cerebral cortex (New York, N.Y. : 1991), 2015, Volume: 25, Issue:5

    Topics: Aging; Animals; Electrophysiology; Female; GABAergic Neurons; gamma-Aminobutyric Acid; Glutamate Dec

2015
The aging human cochlear nucleus: Changes in the glial fibrillary acidic protein, intracellular calcium regulatory proteins, GABA neurotransmitter and cholinergic receptor.
    Journal of chemical neuroanatomy, 2014, Volume: 56

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Autopsy; Calcium-Binding Proteins; Child, Prescho

2014
Beta oscillations reflect changes in motor cortex inhibition in healthy ageing.
    NeuroImage, 2014, May-01, Volume: 91

    Topics: Adult; Aged; Aged, 80 and over; Aging; Beta Rhythm; Cortical Synchronization; Data Interpretation, S

2014
Longitudinal neurochemical modifications in the aging mouse brain measured in vivo by 1H magnetic resonance spectroscopy.
    Neurobiology of aging, 2014, Volume: 35, Issue:7

    Topics: Aging; Alanine; Animals; Cerebral Cortex; Cognition; Corpus Striatum; Energy Metabolism; Ethanolamin

2014
Altered glutamate/GABA equilibrium in aged mice cortex influences cortical plasticity.
    Brain structure & function, 2015, Volume: 220, Issue:3

    Topics: Aging; Animals; Conditioning, Classical; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; G

2015
Astrocyte-dependent protective effect of quetiapine on GABAergic neuron is associated with the prevention of anxiety-like behaviors in aging mice after long-term treatment.
    Journal of neurochemistry, 2014, Volume: 130, Issue:6

    Topics: Adenosine Triphosphate; Aging; Animals; Antipsychotic Agents; Anxiety; Astrocytes; Behavior, Animal;

2014
Comparing the inferior colliculus of young and old gerbils (Meriones unguiculatus) with an emphasis on GABA.
    Experimental gerontology, 2014, Volume: 57

    Topics: Aging; Animals; gamma-Aminobutyric Acid; Gerbillinae; Inferior Colliculi

2014
Human induced pluripotent stem cells improve recovery in stroke-injured aged rats.
    Restorative neurology and neuroscience, 2014, Volume: 32, Issue:4

    Topics: Aging; Analysis of Variance; Animals; Brain Injuries; Cell Differentiation; Disease Models, Animal;

2014
Intracellular activities related to in vitro hippocampal sharp waves are altered in CA3 pyramidal neurons of aged mice.
    Neuroscience, 2014, Sep-26, Volume: 277

    Topics: Aging; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; gamma-Aminobutyric Acid; Membrane

2014
In utero exposure to valproic acid changes sleep in juvenile rats: a model for sleep disturbances in autism.
    Sleep, 2014, Sep-01, Volume: 37, Issue:9

    Topics: Aging; Animals; Arousal; Child Development Disorders, Pervasive; Circadian Rhythm; Disease Models, A

2014
Medullary regulation of visceral sympathetic nerve discharge at peak hyperthermia in aged F344 rats.
    Autonomic neuroscience : basic & clinical, 2014, Volume: 186

    Topics: Aging; Animals; Bicuculline; Body Temperature; Fever; GABA-A Receptor Antagonists; gamma-Aminobutyri

2014
Age-dependent effects of environmental enrichment on spatial memory and neurochemistry.
    Neurobiology of learning and memory, 2015, Volume: 118

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Dopamine; Environment; gamma-Aminobutyric Acid; Glut

2015
GABAergic transmission and enhanced modulation by opioids and endocannabinoids in adult rat rostral ventromedial medulla.
    The Journal of physiology, 2015, Jan-01, Volume: 593, Issue:1

    Topics: Action Potentials; Aging; Analgesics, Opioid; Animals; Endocannabinoids; Enkephalin, Ala(2)-MePhe(4)

2015
Developmentally regulated neurosteroid synthesis enhances GABAergic neurotransmission in mouse thalamocortical neurones.
    The Journal of physiology, 2015, Jan-01, Volume: 593, Issue:1

    Topics: 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); 5-alpha-Dihydroprogesterone; Aging; Animals; gamm

2015
The timing of neuronal loss across adolescence in the medial prefrontal cortex of male and female rats.
    Neuroscience, 2015, Aug-20, Volume: 301

    Topics: Aging; Analysis of Variance; Animals; Cell Count; Female; gamma-Aminobutyric Acid; Male; Neuroglia;

2015
Reduction in NPY-positive neurons and dysregulation of excitability in young senescence-accelerated mouse prone 8 (SAMP8) hippocampus precede the onset of cognitive impairment.
    Journal of neurochemistry, 2015, Volume: 135, Issue:2

    Topics: Aging; Animals; Behavior, Animal; Cognition Disorders; Cyclic AMP Response Element-Binding Protein;

2015
Prefrontal cortical GABAergic signaling and impaired behavioral flexibility in aged F344 rats.
    Neuroscience, 2017, 03-14, Volume: 345

    Topics: Aging; Animals; Attention; Baclofen; Discrimination Learning; Executive Function; GABA-B Receptor Ag

2017
Shifts in excitatory/inhibitory balance by juvenile stress: A role for neuron-astrocyte interaction in the dentate gyrus.
    Glia, 2016, Volume: 64, Issue:6

    Topics: Aging; Animals; Astrocytes; Cell Communication; Dentate Gyrus; Electric Stimulation; gamma-Aminobuty

2016
Enhancing GABA Signaling during Middle Adulthood Prevents Age-Dependent GABAergic Interneuron Decline and Learning and Memory Deficits in ApoE4 Mice.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, Feb-17, Volume: 36, Issue:7

    Topics: Aging; Animals; Apolipoprotein E4; Female; GABA Agonists; gamma-Aminobutyric Acid; Gene Knock-In Tec

2016
Age-related changes in anterior cingulate cortex glutamate in schizophrenia: A (1)H MRS Study at 7 Tesla.
    Schizophrenia research, 2016, Volume: 172, Issue:1-3

    Topics: Adult; Aging; Antipsychotic Agents; Aspartic Acid; Choline; Creatine; Dipeptides; Female; gamma-Amin

2016
Age-associated metabolic dysregulation in bone marrow-derived macrophages stimulated with lipopolysaccharide.
    Scientific reports, 2016, Mar-04, Volume: 6

    Topics: Aging; Animals; Arginine; Cells, Cultured; gamma-Aminobutyric Acid; Glycolysis; Inflammation; Lipopo

2016
Age-related gene expression change of GABAergic system in visual cortex of rhesus macaque.
    Gene, 2016, Sep-30, Volume: 590, Issue:2

    Topics: Aging; Animals; Blotting, Western; Female; gamma-Aminobutyric Acid; Gene Expression Regulation, Deve

2016
Early GABAergic transmission defects in the external globus pallidus and rest/activity rhythm alteration in a mouse model of Huntington's disease.
    Neuroscience, 2016, 08-04, Volume: 329

    Topics: Aging; Animals; Disease Models, Animal; Disease Progression; gamma-Aminobutyric Acid; Globus Pallidu

2016
The Role of BDNF in Age-Dependent Changes of Excitatory and Inhibitory Synaptic Markers in the Human Prefrontal Cortex.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016, Volume: 41, Issue:13

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Animals; Brain-Derived Neurotrophic Factor; Femal

2016
Chronic pregabalin treatment decreases excitability of dentate gyrus and accelerates maturation of adult-born granule cells.
    Journal of neurochemistry, 2017, Volume: 140, Issue:2

    Topics: Aging; Animals; Calcium Channels; Cytoplasmic Granules; Dentate Gyrus; Epilepsy; gamma-Aminobutyric

2017
Age-related changes in tonic activation of presynaptic versus extrasynaptic γ-amniobutyric acid type B receptors in rat medial prefrontal cortex.
    Neurobiology of aging, 2016, Volume: 45

    Topics: Aging; Animals; Beclomethasone; Cognition; Executive Function; gamma-Aminobutyric Acid; Male; Neural

2016
Developmental delay in motor skill acquisition in Niemann-Pick C1 mice reveals abnormal cerebellar morphogenesis.
    Acta neuropathologica communications, 2016, 09-01, Volume: 4, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Cerebellum; Cohort Studies; Developmental Disabilities; Disease Mo

2016
GABAergic hyperinnervation of dentate granule cells in the Ts65Dn mouse model of down syndrome: Exploring the role of App.
    Hippocampus, 2016, Volume: 26, Issue:12

    Topics: Aging; Amyloid beta-Protein Precursor; Animals; Cyclin-Dependent Kinase 5; Dentate Gyrus; Disease Mo

2016
α4β2
    Neuroscience, 2017, 01-06, Volume: 340

    Topics: Aging; Animals; Female; gamma-Aminobutyric Acid; Immunohistochemistry; Inhibitory Postsynaptic Poten

2017
Aging-related impairments of hippocampal mossy fibers synapses on CA3 pyramidal cells.
    Neurobiology of aging, 2017, Volume: 49

    Topics: Aging; Animals; CA3 Region, Hippocampal; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid

2017
Glutamate-glutamine and GABA in brain of normal aged and patients with cognitive impairment.
    European radiology, 2017, Volume: 27, Issue:7

    Topics: Adult; Aged; Aging; Alzheimer Disease; Analysis of Variance; Case-Control Studies; Cognitive Dysfunc

2017
Age-dependent concomitant changes in synaptic dysfunction and GABAergic pathway in the APP/PS1 mouse model.
    Acta neurobiologiae experimentalis, 2016, Volume: 76, Issue:4

    Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Dose-Resp

2016
Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis.
    Disease models & mechanisms, 2017, 03-01, Volume: 10, Issue:3

    Topics: Adaptation, Physiological; Aging; Animals; Behavior, Animal; Cocaine; Cognition Disorders; Dentate G

2017
Age-dependent regulation of GABA transmission by kappa opioid receptors in the basolateral amygdala of Sprague-Dawley rats.
    Neuropharmacology, 2017, 05-01, Volume: 117

    Topics: Aging; Animals; Basolateral Nuclear Complex; Benzeneacetamides; gamma-Aminobutyric Acid; Glutamic Ac

2017
Characterization of the influence of age on GABA
    Aging, 2017, 02-16, Volume: 9, Issue:2

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Electroencephalography; Electromyogr

2017
Rapid and stable changes in maturation-related phenotypes of the adult hippocampal neurons by electroconvulsive treatment.
    Molecular brain, 2017, 03-02, Volume: 10, Issue:1

    Topics: Aging; Animals; Biomarkers; Cell Differentiation; Dentate Gyrus; Down-Regulation; Electroshock; gamm

2017
Postnatal changes in somatic gamma-aminobutyric acid signalling in the rat hippocampus.
    The European journal of neuroscience, 2008, Volume: 27, Issue:10

    Topics: Aging; Animals; Animals, Newborn; Cell Differentiation; Cell Membrane; Chloride Channels; gamma-Amin

2008
Neuroactive steroids and GABAA receptor plasticity in the brain of the WAG/Rij rat, a model of absence epilepsy.
    Journal of neurochemistry, 2008, Volume: 106, Issue:6

    Topics: Aging; Animals; Animals, Genetically Modified; Brain; Brain Chemistry; Cerebral Cortex; Desoxycortic

2008
Mechanisms of hyperthermia-induced depression of GABAergic synaptic transmission in the immature rat hippocampus.
    Journal of neurochemistry, 2008, Volume: 106, Issue:5

    Topics: Adenylyl Cyclases; Aging; Animals; Animals, Newborn; Body Temperature; Cyclic AMP-Dependent Protein

2008
Restoration of the luteinizing hormone surge in middle-aged female rats by altering the balance of GABA and glutamate transmission in the medial preoptic area.
    Biology of reproduction, 2008, Volume: 79, Issue:5

    Topics: Age Factors; Aging; Animals; Estradiol; Estrous Cycle; Female; GABA-A Receptor Antagonists; gamma-Am

2008
Retardation in somatosensory cortex development induced by postnatal BrdU treatment in mice.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2008, Volume: 26, Issue:7

    Topics: Action Potentials; Aging; Animals; Animals, Newborn; Antimetabolites; Biomarkers; Bromodeoxyuridine;

2008
Effect of bacterial lipopolysaccharide on the reproductive axis of prepubertal and peripubertal female rats. Ontogenic changes in the immune-neuroendocrine interactions.
    Neuroimmunomodulation, 2008, Volume: 15, Issue:2

    Topics: Adipose Tissue; Aging; Animals; Bacterial Infections; Female; gamma-Aminobutyric Acid; Glutamic Acid

2008
Synaptic transmission from the supratrigeminal region to jaw-closing and jaw-opening motoneurons in developing rats.
    Journal of neurophysiology, 2008, Volume: 100, Issue:4

    Topics: Aging; Animals; Electrophysiology; gamma-Aminobutyric Acid; In Vitro Techniques; Jaw; Masticatory Mu

2008
Changes in glutamate decarboxylase enzyme activity and tau-protein phosphorylation in the hippocampus of old rats exposed to chronic mild stress: reversal with the neuronal nitric oxide synthase inhibitor 7-nitroindazole.
    Pharmacology, biochemistry, and behavior, 2009, Volume: 91, Issue:3

    Topics: Aging; Animals; Blotting, Western; Chromatography, High Pressure Liquid; Chronic Disease; Enzyme Inh

2009
Neurotransmitter release during delay eyeblink classical conditioning: role of norepinephrine in consolidation and effect of age.
    Neurobiology of learning and memory, 2009, Volume: 92, Issue:3

    Topics: Adrenergic beta-Antagonists; Aging; Animals; Association Learning; Cerebellum; Conditioning, Eyelid;

2009
GABAergic mechanism of propofol toxicity in immature neurons.
    Journal of neurosurgical anesthesiology, 2008, Volume: 20, Issue:4

    Topics: Aging; Anesthetics, Intravenous; Animals; Calcium; Calcium Channel Agonists; Calcium Channels, L-Typ

2008
17beta-estradiol affects GABAergic transmission in developing hippocampus.
    Brain research, 2008, Nov-19, Volume: 1241

    Topics: Age Factors; Aging; Animals; Drug Administration Schedule; Estradiol; Excitatory Amino Acid Antagoni

2008
Age-related changes in GAD levels in the central auditory system of the rat.
    Experimental gerontology, 2009, Volume: 44, Issue:3

    Topics: Aging; Analysis of Variance; Animals; Auditory Cortex; Blotting, Western; gamma-Aminobutyric Acid; G

2009
A neonatal ventral hippocampal lesion causes functional deficits in adult prefrontal cortical interneurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, Nov-26, Volume: 28, Issue:48

    Topics: Aging; Animals; Animals, Newborn; Biomarkers; Denervation; Dopamine Agonists; gamma-Aminobutyric Aci

2008
Enhanced adaptation of visual cortical cells to visual stimulation in aged cats.
    Neuroscience letters, 2009, Feb-13, Volume: 451, Issue:1

    Topics: Adaptation, Physiological; Aging; Animals; Cats; Electrophysiology; gamma-Aminobutyric Acid; Membran

2009
Age-dependent enhancement of inhibitory synaptic transmission in CA1 pyramidal neurons via GluR5 kainate receptors.
    Hippocampus, 2009, Volume: 19, Issue:8

    Topics: Aging; Animals; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Inhibitory

2009
Axon regeneration requires a conserved MAP kinase pathway.
    Science (New York, N.Y.), 2009, Feb-06, Volume: 323, Issue:5915

    Topics: Aging; Animals; Axons; Axotomy; Caenorhabditis elegans; Caenorhabditis elegans Proteins; gamma-Amino

2009
Release of endogenous amino acids from the hippocampus and brain stem from developing and adult mice in ischemia.
    Neurochemical research, 2009, Volume: 34, Issue:9

    Topics: Aging; Alanine; Animals; Aspartic Acid; Brain Ischemia; Brain Stem; Female; gamma-Aminobutyric Acid;

2009
GABAA receptors mediate excitation in adult rat GnRH neurons.
    Biology of reproduction, 2009, Volume: 81, Issue:2

    Topics: Aging; Animals; Calcium; Calcium Signaling; Cells, Cultured; Chi-Square Distribution; Circadian Rhyt

2009
Effects of temperature elevation on neuronal inhibition in hippocampal neurons of immature and mature rats.
    Journal of neuroscience research, 2009, Volume: 87, Issue:12

    Topics: Aging; Animals; Animals, Newborn; Body Temperature; Cell Differentiation; Dentate Gyrus; Female; Fev

2009
IL-6 mediated degeneration of forebrain GABAergic interneurons and cognitive impairment in aged mice through activation of neuronal NADPH oxidase.
    PloS one, 2009, Volume: 4, Issue:5

    Topics: Aging; Animals; Cell Nucleus; Cognition; gamma-Aminobutyric Acid; Interleukin-6; Interneurons; Membr

2009
Age- and gender-related differences in GABAA receptor-mediated postsynaptic currents in GABAergic neurons of the substantia nigra reticulata in the rat.
    Neuroscience, 2009, Sep-29, Volume: 163, Issue:1

    Topics: Aging; Animals; Cell Differentiation; Female; GABA Agonists; GABA-A Receptor Agonists; gamma-Aminobu

2009
Synchronization of GABAergic inputs to CA3 pyramidal cells precedes seizure-like event onset in juvenile rat hippocampal slices.
    Journal of neurophysiology, 2009, Volume: 102, Issue:4

    Topics: Aging; Animals; CA3 Region, Hippocampal; Chlorides; GABA Antagonists; gamma-Aminobutyric Acid; Gluta

2009
Age-related changes in arginine and its metabolites in memory-associated brain structures.
    Neuroscience, 2009, Dec-01, Volume: 164, Issue:2

    Topics: Aging; Analysis of Variance; Animals; Arginase; Arginine; Brain; Citrulline; gamma-Aminobutyric Acid

2009
Arcuate nucleus expression of NKX2.1 and DLX and lineages expressing these transcription factors in neuropeptide Y(+), proopiomelanocortin(+), and tyrosine hydroxylase(+) neurons in neonatal and adult mice.
    The Journal of comparative neurology, 2009, Nov-01, Volume: 517, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus; Cell Count; Cell Lineage; gamma-A

2009
Accumulation of reelin-positive plaques is accompanied by a decline in basal forebrain projection neurons during normal aging.
    The European journal of neuroscience, 2009, Volume: 30, Issue:6

    Topics: Aging; Analysis of Variance; Animals; Astrocytes; Calbindins; Cell Adhesion Molecules, Neuronal; Cel

2009
Ongoing expression of Nkx2.1 in the postnatal mouse forebrain: potential for understanding NKX2.1 haploinsufficiency in humans?
    Brain research, 2009, Dec-22, Volume: 1304

    Topics: Acetylcholine; Aging; Animals; Animals, Newborn; Female; gamma-Aminobutyric Acid; Glutamate Decarbox

2009
Processing of broadband stimuli across A1 layers in young and aged rats.
    Hearing research, 2010, Jun-01, Volume: 264, Issue:1-2

    Topics: Acoustic Stimulation; Age Factors; Aging; Animals; Auditory Cortex; Auditory Pathways; Auditory Perc

2010
Gamma-aminobutyric acid and glutamate differentially regulate intracellular calcium concentrations in mouse gonadotropin-releasing hormone neurons.
    Endocrinology, 2010, Volume: 151, Issue:1

    Topics: Aging; Animals; Calcium; Calcium Signaling; Female; gamma-Aminobutyric Acid; Glutamic Acid; Gonadotr

2010
Postnatal exposure to MK801 induces selective changes in GAD67 or parvalbumin.
    Experimental brain research, 2010, Volume: 201, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Cell Count; Cell Differentiation; Disease Models, Animal; Dizocilp

2010
Oxytocin and vasopressin enhance synaptic transmission in the hypoglossal motor nucleus of young rats by acting on distinct receptor types.
    Neuroscience, 2010, Feb-03, Volume: 165, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Axons; Cell Membrane; Dendrites; Excitatory Postsynaptic Potential

2010
Bidirectional plasticity in fast-spiking GABA circuits by visual experience.
    Nature, 2009, Nov-12, Volume: 462, Issue:7270

    Topics: Action Potentials; Aging; Animals; Dominance, Ocular; gamma-Aminobutyric Acid; Interneurons; Mice; M

2009
Promoting directional axon growth from neural progenitors grafted into the injured spinal cord.
    Journal of neuroscience research, 2010, May-01, Volume: 88, Issue:6

    Topics: Aging; Animals; Axons; Brain-Derived Neurotrophic Factor; Cell Enlargement; Female; gamma-Aminobutyr

2010
Seizures in the developing brain result in a long-lasting decrease in GABA(B) inhibitory postsynaptic currents in the rat hippocampus.
    Neurobiology of disease, 2010, Volume: 37, Issue:3

    Topics: Action Potentials; Age Factors; Aging; Animals; Animals, Newborn; CA1 Region, Hippocampal; Dentate G

2010
Immature brains don't need GABA to get 'hyper'-excited.
    The Journal of physiology, 2010, Jan-01, Volume: 588, Issue:Pt 1

    Topics: Action Potentials; Aging; Animals; Biological Clocks; Cells, Cultured; gamma-Aminobutyric Acid; Hipp

2010
Age- and dose-specific anticonvulsant action of bumetanide in immature rats.
    Physiological research, 2009, Volume: 58, Issue:6

    Topics: Age Factors; Aging; Animals; Anticonvulsants; Bumetanide; Disease Models, Animal; Dose-Response Rela

2009
Plasticity of synaptic inhibition in mouse spinal cord lamina II neurons during early postnatal development and after inactivation of the glycine receptor alpha3 subunit gene.
    The European journal of neuroscience, 2009, Volume: 30, Issue:12

    Topics: Aging; Animals; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Inhibitory Postsynaptic Poten

2009
Deletion of Cav2.1(alpha1(A)) subunit of Ca2+-channels impairs synaptic GABA and glutamate release in the mouse cerebellar cortex in cultured slices.
    The European journal of neuroscience, 2009, Volume: 30, Issue:12

    Topics: Aging; Animals; Calcium Channel Blockers; Calcium Channels, N-Type; Calcium Channels, P-Type; Calciu

2009
Vulnerability of hippocampal GABA-ergic interneurons to kainate-induced excitotoxic injury during old age.
    Journal of cellular and molecular medicine, 2009, Volume: 13, Issue:8B

    Topics: Aging; Animals; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Kainic Acid; Male; Rats; Rats, I

2009
Does age matter? Behavioral and neuro-anatomical effects of neonatal and adult basal forebrain cholinergic lesions.
    Journal of Alzheimer's disease : JAD, 2010, Volume: 20, Issue:1

    Topics: Acetylcholine; Age Factors; Aging; Analysis of Variance; Animals; Animals, Newborn; Antibodies, Mono

2010
MeCP2 is required for normal development of GABAergic circuits in the thalamus.
    Journal of neurophysiology, 2010, Volume: 103, Issue:5

    Topics: Aging; Animals; Animals, Newborn; Evoked Potentials; gamma-Aminobutyric Acid; Immunohistochemistry;

2010
Embryonic MGE precursor cells grafted into adult rat striatum integrate and ameliorate motor symptoms in 6-OHDA-lesioned rats.
    Cell stem cell, 2010, Mar-05, Volume: 6, Issue:3

    Topics: Aging; Animals; Behavior, Animal; Cell Differentiation; Cell Movement; Cell Survival; Cell Transplan

2010
Enhanced glutamatergic and decreased GABAergic synaptic appositions to GnRH neurons on proestrus in the rat: modulatory effect of aging.
    PloS one, 2010, Apr-14, Volume: 5, Issue:4

    Topics: Aging; Animals; Diestrus; gamma-Aminobutyric Acid; Glutamic Acid; Gonadotropin-Releasing Hormone; Ne

2010
A photoconvertible reporter of the ubiquitin-proteasome system in vivo.
    Nature methods, 2010, Volume: 7, Issue:6

    Topics: Aging; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Dopamine; gamma-Aminobutyri

2010
Presynaptic interneuron subtype- and age-dependent modulation of GABAergic synaptic transmission by beta-adrenoceptors in rat insular cortex.
    Journal of neurophysiology, 2010, Volume: 103, Issue:5

    Topics: Action Potentials; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Aging; Animals; Cerebral Cor

2010
Activity- and age-dependent modulation of GABAergic neurotransmission by system A-mediated glutamine uptake.
    Journal of neurochemistry, 2010, Volume: 114, Issue:3

    Topics: Aging; Amino Acid Transport System A; Animals; Carrier Proteins; gamma-Aminobutyric Acid; Glutamic A

2010
Sexual dimorphism in shape and distribution of GABA-like immuno-reactive neurons in cricket terminal abdominal ganglion.
    Zoological science, 2010, Volume: 27, Issue:6

    Topics: Aging; Animals; Female; gamma-Aminobutyric Acid; Ganglia, Invertebrate; Gryllidae; Male; Neurons; Se

2010
Endogenous signaling through alpha7-containing nicotinic receptors promotes maturation and integration of adult-born neurons in the hippocampus.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Jun-30, Volume: 30, Issue:26

    Topics: Adult Stem Cells; Aging; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cell Survival; Dendrites;

2010
A multivariate analysis of the effects of aging on glutamate, GABA and arginine metabolites in the rat vestibular nucleus.
    Hearing research, 2010, Oct-01, Volume: 269, Issue:1-2

    Topics: Aging; Animals; Arginine; Cerebellum; Cluster Analysis; gamma-Aminobutyric Acid; Glutamic Acid; Male

2010
Decreased glutamic acid decarboxylase mRNA expression in prefrontal cortex in Parkinson's disease.
    Experimental neurology, 2010, Volume: 226, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aging; Autoradiography; Brain Chemistry; gamma-Aminobutyric Acid; Gl

2010
Laminar-specific maturation of GABAergic transmission and susceptibility to visual deprivation are related to endocannabinoid sensitivity in mouse visual cortex.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Oct-20, Volume: 30, Issue:42

    Topics: Aging; Animals; Cannabinoid Receptor Modulators; Electric Stimulation; Endocannabinoids; Evoked Pote

2010
The immunohistochemical examination of GABAergic interneuron markers in the dorsolateral prefrontal cortex of patients with late-life depression.
    International psychogeriatrics, 2011, Volume: 23, Issue:4

    Topics: Aged; Aged, 80 and over; Aging; Biomarkers; Calbindin 2; Case-Control Studies; Depression; Female; g

2011
Insufficient augmentation of ambient GABA responsible for age-related cognitive deficit.
    Cognitive processing, 2011, Volume: 12, Issue:2

    Topics: Aging; Cognition Disorders; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans

2011
Direct and indirect control of orexin/hypocretin neurons by glycine receptors.
    The Journal of physiology, 2011, Feb-01, Volume: 589, Issue:Pt 3

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Alanine; Animals; Animals, Newborn; Benzothiadiazines;

2011
Interneuron loss reduces dendritic inhibition and GABA release in hippocampus of aged rats.
    Neurobiology of aging, 2012, Volume: 33, Issue:2

    Topics: Aging; Animals; Cell Count; Dendrites; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Male; Neu

2012
Comparison of metabolic profiling of cyanidin-3-O-galactoside and extracts from blueberry in aged mice.
    Journal of agricultural and food chemistry, 2011, Mar-09, Volume: 59, Issue:5

    Topics: Aging; Animals; Anthocyanins; Blueberry Plants; Brain Chemistry; Choline; Fruit; Galactosides; gamma

2011
Excitatory-inhibitory imbalance in hypoglossal neurons during the critical period of postnatal development in the rat.
    The Journal of physiology, 2011, Apr-15, Volume: 589, Issue:Pt 8

    Topics: Age Factors; Aging; Analysis of Variance; Animals; Animals, Newborn; Brain Stem; Electric Stimulatio

2011
GABA transport modulates the ethanol sensitivity of tonic inhibition in the rat dentate gyrus.
    Alcohol (Fayetteville, N.Y.), 2011, Volume: 45, Issue:6

    Topics: Aging; Animals; Dentate Gyrus; Ethanol; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric

2011
Activation of presynaptic GABAB receptors modulates GABAergic and glutamatergic inputs to the medial geniculate body.
    Hearing research, 2011, Volume: 280, Issue:1-2

    Topics: Aging; Animals; Baclofen; Electric Stimulation; Excitatory Postsynaptic Potentials; Female; GABA-B R

2011
Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Jul-05, Volume: 108, Issue:27

    Topics: Aging; Animals; Brain; Cell Count; Female; gamma-Aminobutyric Acid; Gene Expression; Hippocampus; In

2011
Age-dependent homeostatic plasticity of GABAergic signaling in developing retinal networks.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Aug-24, Volume: 31, Issue:34

    Topics: Action Potentials; Aging; Animals; Animals, Newborn; Bicuculline; GABA Antagonists; gamma-Aminobutyr

2011
Early age conductive hearing loss causes audiogenic seizure and hyperacusis behavior.
    Hearing research, 2011, Volume: 282, Issue:1-2

    Topics: Acoustic Stimulation; Age Factors; Aging; Animals; Anticonvulsants; Auditory Perception; Behavior, A

2011
Effect of dietary γ-aminobutyric acid on the brain protein synthesis rate in hypophysectomized aged rats.
    Journal of nutritional science and vitaminology, 2011, Volume: 57, Issue:4

    Topics: Aging; Animals; Brain; Diet; GABA Agents; gamma-Aminobutyric Acid; Growth Hormone; Hypophysectomy; M

2011
Spatial and temporal distribution patterns of enkephalinergic neurons in adult and developing retinas of the preproenkephalin-green fluorescent protein transgenic mouse.
    Cells, tissues, organs, 2012, Volume: 195, Issue:6

    Topics: Aging; Animals; Enkephalins; gamma-Aminobutyric Acid; Glycine Plasma Membrane Transport Proteins; Gr

2012
GABA is depolarizing in hippocampal dentate granule cells of the adolescent and adult rats.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Jan-04, Volume: 32, Issue:1

    Topics: Action Potentials; Aging; Animals; Dentate Gyrus; Excitatory Postsynaptic Potentials; gamma-Aminobut

2012
GABA is excitatory in adult vasopressinergic neuroendocrine cells.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Jan-11, Volume: 32, Issue:2

    Topics: Aging; Animals; Excitatory Postsynaptic Potentials; GABAergic Neurons; gamma-Aminobutyric Acid; Male

2012
Mutant TDP-43 and FUS cause age-dependent paralysis and neurodegeneration in C. elegans.
    PloS one, 2012, Volume: 7, Issue:2

    Topics: Aging; Animals; Animals, Genetically Modified; Caenorhabditis elegans; DNA-Binding Proteins; gamma-A

2012
Corticosterone promotes emergence of fictive air breathing in Xenopus laevis Daudin tadpole brainstems.
    The Journal of experimental biology, 2012, Apr-01, Volume: 215, Issue:Pt 7

    Topics: Aging; Air; Animals; Brain Stem; Corticosterone; gamma-Aminobutyric Acid; In Vitro Techniques; Larva

2012
Absence of changes in GABA concentrations with age and gender in the human anterior cingulate cortex: a MEGA-PRESS study with symmetric editing pulse frequencies for macromolecule suppression.
    Magnetic resonance in medicine, 2013, Volume: 69, Issue:2

    Topics: Adult; Aging; Algorithms; Female; gamma-Aminobutyric Acid; Gyrus Cinguli; Humans; Macromolecular Sub

2013
[Efficacy of convalis in the treatment of pain diabetic polyneuropathy and it's influence on biological age].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2012, Volume: 112, Issue:1

    Topics: Adult; Age Factors; Aging; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Diabetic Neuropathi

2012
IGF-1 restores visual cortex plasticity in adult life by reducing local GABA levels.
    Neural plasticity, 2012, Volume: 2012

    Topics: Aging; Animals; gamma-Aminobutyric Acid; Insulin-Like Growth Factor I; Microdialysis; Nerve Net; Neu

2012
Dynamic modulation of an orientation preference map by GABA responsible for age-related cognitive performance.
    Cognitive processing, 2012, Volume: 13, Issue:4

    Topics: Action Potentials; Aging; Animals; Cognition; Computer Simulation; gamma-Aminobutyric Acid; Models,

2012
Postnatal development of 2 microcircuits involving fast-spiking interneurons in the mouse prefrontal cortex.
    Cerebral cortex (New York, N.Y. : 1991), 2014, Volume: 24, Issue:1

    Topics: Aging; Animals; Blotting, Western; Electrophysiological Phenomena; Excitatory Postsynaptic Potential

2014
Development of the Islands of Calleja.
    Brain research, 2013, Jan-15, Volume: 1490

    Topics: Aging; Animals; Calcium-Binding Proteins; Coloring Agents; gamma-Aminobutyric Acid; Glutamate Decarb

2013
Diminished cortical inhibition in an aging mouse model of chronic tinnitus.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Nov-14, Volume: 32, Issue:46

    Topics: Acoustic Stimulation; Aging; Animals; Auditory Cortex; Auditory Threshold; Cerebral Cortex; Chronic

2012
Reduced GABA(A) receptor-mediated tonic inhibition in aged rat auditory thalamus.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Jan-16, Volume: 33, Issue:3

    Topics: Aging; Animals; Auditory Pathways; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Memb

2013
Diets enriched in foods with high antioxidant activity reverse age-induced decreases in cerebellar beta-adrenergic function and increases in proinflammatory cytokines.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Jul-15, Volume: 22, Issue:14

    Topics: Aging; Animals; Antioxidants; Bacterial Proteins; Cerebellum; Cucumis sativus; Cytokines; Dietary Su

2002
Dark rearing alters the development of GABAergic transmission in visual cortex.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Sep-15, Volume: 22, Issue:18

    Topics: Aging; Animals; Cell Differentiation; Critical Period, Psychological; Darkness; Excitatory Postsynap

2002
Postnatal development of parvalbumin and calbindin D-28k immunoreactivities in the canine anterior cingulate cortex: transient expression in layer V pyramidal cells.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2002, Volume: 20, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Calbindins; Cell Differentiation; Cell Movement; Dogs; Down-Regula

2002
Quantitative immunocytochemistry of GABA and synaptophysin in the cerebellar cortex of old ethanol-fed rats.
    Alcoholism, clinical and experimental research, 2002, Volume: 26, Issue:11

    Topics: Aging; Animals; Cerebellar Cortex; Ethanol; gamma-Aminobutyric Acid; Immunohistochemistry; Male; Rat

2002
Characterization of GABA(A) and glycine receptors in neurons of the developing rat inferior colliculus.
    Pflugers Archiv : European journal of physiology, 2002, Volume: 445, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Electric Conductivity; gamma-Aminobutyric Acid; Glycine; In Vitro

2002
Developmental changes in short-term synaptic depression in the neonatal mouse spinal cord.
    Journal of neurophysiology, 2002, Volume: 88, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Calcium; Electric Stimulation; Excitatory Postsynaptic Potentials;

2002
Transport of 14C-gamma-aminobutyric acid into brain, cerebrospinal fluid and choroid plexus in neonatal and adult rats.
    Brain research. Developmental brain research, 2002, Dec-15, Volume: 139, Issue:2

    Topics: Aging; Amino Acids, Cyclic; Animals; Animals, Newborn; beta-Alanine; Biological Transport, Active; B

2002
Influence of neurotrophins on the synaptogenesis of inner hair cells in the deaf Bronx waltzer (bv) mouse organ of Corti in culture.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2002, Volume: 20, Issue:7

    Topics: Aging; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Cell Count; Cell Differentiatio

2002
Postnatal development of GABAergic signalling in the rat lateral geniculate nucleus: presynaptic dendritic mechanisms.
    The Journal of physiology, 2003, Jan-01, Volume: 546, Issue:Pt 1

    Topics: Aging; Animals; Animals, Newborn; Axons; Dendrites; Electrophysiology; GABA-A Receptor Antagonists;

2003
Parallel decrease in omega-conotoxin-sensitive transmission and dopamine-induced inhibition at the striatal synapse of developing rats.
    The Journal of physiology, 2003, Jan-15, Volume: 546, Issue:Pt 2

    Topics: Agatoxins; Aging; Animals; Animals, Newborn; Calcium Channel Blockers; Cholinergic Fibers; Corpus St

2003
Age-dependent modulation of hippocampal excitability by KCNQ-channels.
    Epilepsy research, 2003, Volume: 53, Issue:1-2

    Topics: Aging; Animals; Biosensing Techniques; Cortical Spreading Depression; Epilepsy, Benign Neonatal; gam

2003
Elimination and strengthening of glycinergic/GABAergic connections during tonotopic map formation.
    Nature neuroscience, 2003, Volume: 6, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Auditory Pathways; Brain Mapping; Cluster Analysis; gamma-Aminobut

2003
Long-term potentiation is increased in the CA1 area of the hippocampus of APP(swe/ind) CRND8 mice.
    Neurobiology of disease, 2002, Volume: 11, Issue:3

    Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Electroph

2002
The small conductance Ca2+-activated K+ channel SK3 is localized in nerve terminals of excitatory synapses of cultured mouse hippocampal neurons.
    The European journal of neuroscience, 2003, Volume: 17, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Brain Chemistry; Calcium; Cell Count; Cells, Cultured; Disks Large

2003
Excitatory actions of endogenously released GABA contribute to initiation of ictal epileptiform activity in the developing hippocampus.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Mar-01, Volume: 23, Issue:5

    Topics: Action Potentials; Aging; Animals; Animals, Newborn; Epilepsy; Excitatory Amino Acid Antagonists; GA

2003
Rat hippocampal GABAergic molecular markers are differentially affected by ageing.
    Journal of neurochemistry, 2003, Volume: 85, Issue:2

    Topics: Aging; Animals; Biomarkers; Calbindin 2; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocamp

2003
Increased neurosteroid sensitivity of hippocampal GABAA receptors during postnatal development.
    Neuroscience, 2003, Volume: 118, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Cell Membrane; Cells, Cultured; Dentate Gyrus; Dose-Response Relat

2003
Cell proliferation in response to GABA in postnatal hippocampal slice culture.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2003, Volume: 21, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Cell Division; Culture Techniques; gamma-Aminobutyric Acid; Hippoc

2003
Effects of 8-OH-DPAT on open field performance of young and aged rats prenatally exposed to diazepam: a tool to reveal 5-HT1A receptor function.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2003, Volume: 13, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Anti-Anxiety Agents; Behavior, Animal; Diaze

2003
Neuroscience. Old neurons revisit their youth.
    Science (New York, N.Y.), 2003, May-02, Volume: 300, Issue:5620

    Topics: Aging; Animals; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Macaca; Muscimol; Neurons;

2003
GABA and its agonists improved visual cortical function in senescent monkeys.
    Science (New York, N.Y.), 2003, May-02, Volume: 300, Issue:5620

    Topics: Aging; Animals; Bicuculline; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Macaca fascic

2003
Early postnatal sound exposure induces lasting neuronal changes in the inferior colliculus of senescence accelerated mice (SAMP8): a morphometric study on GABAergic neurons and NMDA expression.
    Cellular and molecular neurobiology, 2003, Volume: 23, Issue:2

    Topics: Acoustic Stimulation; Aging; Animals; Animals, Newborn; Female; gamma-Aminobutyric Acid; Inferior Co

2003
Expression and function of chloride transporters during development of inhibitory neurotransmission in the auditory brainstem.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, May-15, Volume: 23, Issue:10

    Topics: Aging; Animals; Brain Stem; Cochlear Nerve; Evoked Potentials, Auditory, Brain Stem; gamma-Aminobuty

2003
Retinal remodeling triggered by photoreceptor degenerations.
    The Journal of comparative neurology, 2003, Sep-08, Volume: 464, Issue:1

    Topics: Aging; Amino Acids; Animals; Animals, Genetically Modified; Cell Death; Cell Movement; Disease Model

2003
Expression of GABA transporters, GAT-1 and GAT-3, in the cerebral cortex and thalamus of the rat during postnatal development.
    Cell and tissue research, 2003, Volume: 313, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Antibodies, Monoclonal; Astrocytes; Carrier Proteins; Cerebral Cor

2003
Contrasting expression of Kv4.3, an A-type K+ channel, in migrating Purkinje cells and other post-migratory cerebellar neurons.
    The European journal of neuroscience, 2003, Volume: 18, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Cell Aggregation; Cell Movement; Cerebellum; Embryo, Mammalian; ga

2003
CHANGES IN GLUTAMIC ACID, GLUTAMINE, AND GAMMA-AMINOBUTYRIC ACID CONCENTRATIONS DURING POSTNATAL MATURATION OF THE CAT BRAIN.
    Acta medica Iugoslavica, 1964, Volume: 18

    Topics: Aging; Aminobutyrates; Brain; Brain Chemistry; Cats; gamma-Aminobutyric Acid; Glutamates; Glutamic A

1964
Widely expressed transcripts for chemokine receptor CXCR1 in identified glutamatergic, gamma-aminobutyric acidergic, and cholinergic neurons and astrocytes of the rat brain: a single-cell reverse transcription-multiplex polymerase chain reaction study.
    Journal of neuroscience research, 2003, Oct-15, Volume: 74, Issue:2

    Topics: Acetylcholine; Aging; Animals; Animals, Newborn; Astrocytes; Brain; Cell Line; Cell Separation; Fema

2003
Perinatal iron deficiency alters the neurochemical profile of the developing rat hippocampus.
    The Journal of nutrition, 2003, Volume: 133, Issue:10

    Topics: Aging; Animals; Aspartic Acid; Body Weight; Brain; Brain Chemistry; Creatine; Ethanolamines; Female;

2003
Stress impairs alpha(1A) adrenoceptor-mediated noradrenergic facilitation of GABAergic transmission in the basolateral amygdala.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2004, Volume: 29, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adrenergic alpha-Antagonists; Adr

2004
Boosting GABA improves impaired auditory temporal resolution in the gerbil.
    Neuroreport, 2003, Oct-06, Volume: 14, Issue:14

    Topics: Acoustic Stimulation; Aging; Animals; Anticonvulsants; Auditory Pathways; Auditory Perceptual Disord

2003
Age-related modifications of the morphological organization of pituicytes are associated with alteration of the GABAergic and dopaminergic innervation afferent to the neurohypophysial lobe.
    The European journal of neuroscience, 2003, Volume: 18, Issue:7

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Afferent Pathways; Aging; Animals; Astro

2003
The neonatal ventral hippocampal lesion model of schizophrenia: effects on dopamine and GABA mRNA markers in the rat midbrain.
    The European journal of neuroscience, 2003, Volume: 18, Issue:11

    Topics: Aging; Animals; Animals, Newborn; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transpo

2003
Changes of prolactin regulatory mechanisms in aging: 24-h rhythms of serum prolactin and median eminence and adenohypophysial concentration of dopamine, serotonin, (gamma-aminobutyric acid, taurine and somatostatin in young and aged rats.
    Experimental gerontology, 2004, Volume: 39, Issue:1

    Topics: Aging; Animals; Circadian Rhythm; Dopamine; gamma-Aminobutyric Acid; Male; Median Eminence; Pituitar

2004
Age- and region-dependent alterations in the GABAergic innervation in the brain of rats treated with amphetamine.
    The international journal of neuropsychopharmacology, 2004, Volume: 7, Issue:1

    Topics: Aging; Amphetamine; Animals; Behavior, Animal; Brain; Central Nervous System Stimulants; gamma-Amino

2004
Developmental changes in GABAergic actions and seizure susceptibility in the rat hippocampus.
    The European journal of neuroscience, 2004, Volume: 19, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Bicuculline; Disease Susceptibility; Excitatory Postsynaptic Poten

2004
GABAA receptor subunit mRNA expression in cultured embryonic and adult human dorsal root ganglion neurons.
    Brain research. Developmental brain research, 2004, Apr-19, Volume: 149, Issue:2

    Topics: Aging; Bicuculline; Blotting, Southern; Cells, Cultured; Central Nervous System Stimulants; Drug Int

2004
S 18986, a positive modulator of AMPA receptors with cognition-enhancing properties, increases ACh release in the hippocampus of young and aged rat.
    Neuroscience letters, 2004, May-06, Volume: 361, Issue:1-3

    Topics: Acetylcholine; Aging; Animals; Avoidance Learning; Benzothiadiazines; Dose-Response Relationship, Dr

2004
[Hyperexcitability CA1 neurons induced by brief episodes of hypoxia in hippocampal slices in rats of various age groups].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2004, Volume: 90, Issue:1

    Topics: Action Potentials; Aging; Animals; Cell Hypoxia; Electric Stimulation; Epilepsy; Excitatory Postsyna

2004
Glutamic acid decarboxylase 67 (GAD67) gene expression in discrete regions of the rostral preoptic area change during the oestrous cycle and with age.
    Journal of neuroendocrinology, 2004, Volume: 16, Issue:8

    Topics: Aging; Animals; Circadian Rhythm; Estrous Cycle; Female; gamma-Aminobutyric Acid; Gene Expression Re

2004
Age-dependent changes in the lateral superior olive of the gerbil (Meriones unguiculatus).
    Hearing research, 2004, Volume: 194, Issue:1-2

    Topics: Aging; Animals; Auditory Pathways; Cell Count; gamma-Aminobutyric Acid; Gerbillinae; Glycine; Humans

2004
Stage-dependent dynamics and modulation of spontaneous waves in the developing rabbit retina.
    The Journal of physiology, 2004, Oct-15, Volume: 560, Issue:Pt 2

    Topics: Aging; Animals; Animals, Newborn; Electrophysiology; Embryo, Mammalian; Embryonic Development; gamma

2004
Within-subject memory decline in middle-aged rats: effects of intraseptal tacrine.
    Neurobiology of aging, 2004, Volume: 25, Issue:9

    Topics: Acetylcholine; Aging; Animals; Catheterization; Cholinergic Fibers; Drug Administration Routes; Earl

2004
Gamma-aminobutyric acidergic interneuron vulnerability to aging in canine prefrontal cortex.
    Journal of neuroscience research, 2004, Sep-15, Volume: 77, Issue:6

    Topics: Aging; Amyloid beta-Peptides; Animals; Cell Survival; Dogs; Female; gamma-Aminobutyric Acid; Interne

2004
Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors.
    Proceedings of the National Academy of Sciences of the United States of America, 2004, Sep-14, Volume: 101, Issue:37

    Topics: Aging; Animals; Basic Helix-Loop-Helix Transcription Factors; Behavior, Animal; Brain; Cell Adhesion

2004
Axon mediated interneuron migration.
    Journal of neuropathology and experimental neurology, 2004, Volume: 63, Issue:9

    Topics: Aging; Animals; Axons; Cell Adhesion Molecules, Neuronal; Cell Communication; Cell Differentiation;

2004
A mouse model for Finnish variant late infantile neuronal ceroid lipofuscinosis, CLN5, reveals neuropathology associated with early aging.
    Human molecular genetics, 2004, Dec-01, Volume: 13, Issue:23

    Topics: Aging; Animals; Base Sequence; Brain; Disease Models, Animal; DNA Primers; gamma-Aminobutyric Acid;

2004
Spatial distribution of inhibitory synaptic connections during development of ferret primary visual cortex.
    Experimental brain research, 2005, Volume: 160, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Cell Differentiation; Cell Shape; Electric Stimulation; Excitatory

2005
The 16th Annual Meeting of the Winter Conference on Neural Plasticity. St. Lucia, West Indies. February 21-28, 2004.
    CNS drug reviews, 2004,Fall, Volume: 10, Issue:3

    Topics: Aging; Animals; Brain; Brain-Derived Neurotrophic Factor; gamma-Aminobutyric Acid; Gene Expression;

2004
Association between patient age and gabapentin serum concentration-to-dose ratio: a preliminary multivariate analysis.
    Therapeutic drug monitoring, 2004, Volume: 26, Issue:6

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Amines; Analysis of Variance; Child;

2004
A developmental switch in the excitability and function of the starburst network in the mammalian retina.
    Neuron, 2004, Dec-02, Volume: 44, Issue:5

    Topics: Acetylcholine; Aging; Animals; Electrophysiology; Embryo, Mammalian; gamma-Aminobutyric Acid; In Vit

2004
Characteristics and determinants of normal sleep.
    The Journal of clinical psychiatry, 2004, Volume: 65 Suppl 16

    Topics: Activity Cycles; Age Factors; Aging; Central Nervous System Stimulants; Circadian Rhythm; Ethanol; g

2004
Dopamine and GABA increases produced by activation of glutamate receptors in the nucleus accumbens are decreased during aging.
    Neurobiology of aging, 2005, Volume: 26, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Ana

2005
Postnatal developmental expressions of neurotransmitters and receptors in various brain stem nuclei of rats.
    Journal of applied physiology (Bethesda, Md. : 1985), 2005, Volume: 98, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Brain Stem; gamma-Aminobutyric Acid; Gene Expression Regulation, D

2005
Time-matched pre- and postsynaptic changes of GABAergic synaptic transmission in the developing mouse superior colliculus.
    The Journal of physiology, 2005, Mar-15, Volume: 563, Issue:Pt 3

    Topics: Action Potentials; Aging; Animals; Animals, Newborn; Cells, Cultured; Computer Simulation; Evoked Po

2005
Effects of the metabotropic glutamate receptor agonist, ACPD, on the extracellular concentrations of GABA and acetylcholine in the prefrontal cortex of the rat during the normal process of aging.
    Brain research bulletin, 2005, Feb-15, Volume: 65, Issue:1

    Topics: Acetylcholine; Age Factors; Aging; Analysis of Variance; Animals; Cycloleucine; Dose-Response Relati

2005
Circling behavior and [14C]2-deoxyglucose mapping in rats: possible implications for autistic repetitive behaviors.
    Neurobiology of disease, 2005, Volume: 18, Issue:2

    Topics: Aging; Animals; Autistic Disorder; Autoradiography; Behavior, Animal; Brain; Brain Mapping; Carbon R

2005
Aging reduces center-surround antagonism in visual motion processing.
    Neuron, 2005, Feb-03, Volume: 45, Issue:3

    Topics: Adult; Aged; Aging; Contrast Sensitivity; gamma-Aminobutyric Acid; Humans; Models, Neurological; Mot

2005
Age-dependent spontaneous hyperexcitability and impairment of GABAergic function in the hippocampus of mice lacking trkB.
    Cerebral cortex (New York, N.Y. : 1991), 2006, Volume: 16, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Biological Clocks; Calcium Signaling; gamma-Aminobutyric Acid; Hip

2006
Endogenous neurotrophins are required for the induction of GABAergic long-term potentiation in the neonatal rat hippocampus.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Jun-15, Volume: 25, Issue:24

    Topics: Aging; Animals; Animals, Newborn; Evoked Potentials; gamma-Aminobutyric Acid; Hippocampus; Long-Term

2005
Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy.
    Nature neuroscience, 2005, Volume: 8, Issue:8

    Topics: Aging; Animals; Apoptosis; Behavior, Animal; Brain; Cell Count; Cerebral Cortex; Epilepsy; gamma-Ami

2005
Region- and age-specific deficits in gamma-aminobutyric acidergic neuron development in the telencephalon of the uPAR(-/-) mouse.
    The Journal of comparative neurology, 2005, Sep-05, Volume: 489, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Cell Count; Cell Death; Cell Differentiation; Cell Movement; Femal

2005
Adenosine A2A receptors mediate GABAergic inhibition of respiration in immature rats.
    Journal of applied physiology (Bethesda, Md. : 1985), 2006, Volume: 100, Issue:1

    Topics: Adenosine; Adenosine A2 Receptor Agonists; Aging; Animals; Bicuculline; Biological Clocks; Brain; GA

2006
Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Sep-28, Volume: 25, Issue:39

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-P

2005
High resolution 1H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of Batten disease.
    The Journal of biological chemistry, 2005, Dec-30, Volume: 280, Issue:52

    Topics: Aging; Animals; Aspartic Acid; Brain; Cerebellum; Cerebral Cortex; Creatine; Disease Models, Animal;

2005
Alleviative effects of gamma-aminobutyric acid (GABA) on behavioral abnormalities in aged dogs.
    The Journal of veterinary medical science, 2005, Volume: 67, Issue:10

    Topics: Aging; Animals; Behavioral Symptoms; Dogs; gamma-Aminobutyric Acid; Quality of Life; Surveys and Que

2005
Postnatal changes in functional activities of the pig's brain: a combined functional magnetic resonance imaging and immunohistochemical study.
    Neuro-Signals, 2005, Volume: 14, Issue:5

    Topics: Aging; Animals; Animals, Newborn; Brain; Brain Chemistry; Female; Fluorescent Antibody Technique; ga

2005
Chronic nicotine exposure during adolescence differentially influences calcium-binding proteins in rat anterior cingulate cortex.
    The European journal of neuroscience, 2005, Volume: 22, Issue:10

    Topics: Administration, Oral; Aging; Animals; Calcium-Binding Proteins; Fluorescent Antibody Technique; gamm

2005
Twenty-four hour rhythm of plasma prolactin in female rabbit pups. Correlation with hypothalamic and adenohypophysial dopamine, serotonin, gamma-aminobutyric acid and taurine content.
    Animal reproduction science, 2006, Volume: 91, Issue:1-2

    Topics: Aging; Animals; Animals, Newborn; Circadian Rhythm; Dopamine; Female; gamma-Aminobutyric Acid; Media

2006
Epileptogenic actions of GABA and fast oscillations in the developing hippocampus.
    Neuron, 2005, Dec-08, Volume: 48, Issue:5

    Topics: Aging; Animals; Animals, Newborn; Cellular Senescence; Electrophysiology; Epilepsy; GABA Antagonists

2005
GABA regulates synaptic integration of newly generated neurons in the adult brain.
    Nature, 2006, Feb-02, Volume: 439, Issue:7076

    Topics: Aging; Animals; Brain; Dendrites; Dentate Gyrus; Female; gamma-Aminobutyric Acid; Mice; Mice, Inbred

2006
Immunocytochemical analysis of D-serine distribution in the mammalian brain reveals novel anatomical compartmentalizations in glia and neurons.
    Glia, 2006, Volume: 53, Issue:4

    Topics: Aging; Animals; Biomarkers; Brain; Brain Chemistry; Fixatives; Formaldehyde; gamma-Aminobutyric Acid

2006
Dynamic remodeling of dendritic arbors in GABAergic interneurons of adult visual cortex.
    PLoS biology, 2006, Volume: 4, Issue:2

    Topics: Aging; Animals; Dendrites; gamma-Aminobutyric Acid; Gene Expression Regulation; Mice; Rats; Time Fac

2006
Shift of intracellular chloride concentration in ganglion and amacrine cells of developing mouse retina.
    Journal of neurophysiology, 2006, Volume: 95, Issue:4

    Topics: Action Potentials; Aging; Amacrine Cells; Animals; Animals, Newborn; Calcium; Calcium Channels; Chlo

2006
MRS of normal and impaired fetal brain development.
    European journal of radiology, 2006, Volume: 57, Issue:2

    Topics: Aging; Aspartic Acid; Brain; Choline; Creatine; Female; Fetal Development; Fetus; gamma-Aminobutyric

2006
GABAergic signaling in young granule cells in the adult rat and mouse dentate gyrus.
    Hippocampus, 2006, Volume: 16, Issue:3

    Topics: Aging; Animals; Cell Differentiation; Cell Division; Dentate Gyrus; Doublecortin Domain Proteins; Do

2006
Substantia Gelatinosa neurons in defined-medium organotypic slice culture are similar to those in acute slices from young adult rats.
    Pain, 2006, Volume: 121, Issue:3

    Topics: Action Potentials; Afferent Pathways; Aging; Animals; Chronic Disease; Culture Media; Electric Stimu

2006
Progesterone's effects to reduce anxiety behavior of aged mice do not require actions via intracellular progestin receptors.
    Psychopharmacology, 2006, Volume: 186, Issue:3

    Topics: Aging; Animals; Anxiety; Behavior, Animal; Conflict, Psychological; gamma-Aminobutyric Acid; Hippoca

2006
Relevance of astrocytic activation to reductions of astrocytic GABAA receptors.
    Brain research, 2006, May-17, Volume: 1089, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Astrocytes; Biomarkers; Brain Ischemia; Cell Communication; Cell M

2006
Maintenance of inhibitory interneurons and boutons in sensorimotor cortex between middle and old age in Fischer 344 X Brown Norway rats.
    Journal of chemical neuroanatomy, 2006, Volume: 32, Issue:1

    Topics: Aging; Animals; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Image Processing,

2006
Environmental enrichment promotes neurogenesis and changes the extracellular concentrations of glutamate and GABA in the hippocampus of aged rats.
    Brain research bulletin, 2006, Jun-15, Volume: 70, Issue:1

    Topics: Aging; Analysis of Variance; Animals; Bromodeoxyuridine; Cell Count; Chromatography, High Pressure L

2006
Dietary gamma-aminobutyric acid affects the brain protein synthesis rate in young rats.
    Amino acids, 2007, Volume: 32, Issue:2

    Topics: Aging; Animal Feed; Animals; Body Weight; Brain; Brain Chemistry; Dietary Proteins; gamma-Aminobutyr

2007
Age-related alterations of GABAergic input to CA1 pyramidal neurons and its control by nicotinic acetylcholine receptors in rat hippocampus.
    Neuroscience, 2006, Sep-29, Volume: 142, Issue:1

    Topics: Age Factors; Aging; Alkaloids; Analysis of Variance; Animals; Azocines; Bicuculline; Calbindins; Dos

2006
GABAergic neurons in the lateral superior olive of the hamster are distinguished by differential expression of gad isoforms during development.
    Brain research, 2006, Sep-21, Volume: 1111, Issue:1

    Topics: Aging; Animals; Auditory Pathways; Cell Differentiation; Cochlea; Cricetinae; Efferent Pathways; gam

2006
Prenatal stress and early adoption effects on benzodiazepine receptors and anxiogenic behavior in the adult rat brain.
    Synapse (New York, N.Y.), 2006, Dec-15, Volume: 60, Issue:8

    Topics: Aging; Amygdala; Animals; Animals, Newborn; Anxiety Disorders; Binding Sites; Brain; Down-Regulation

2006
Postnatal expression of alpha2 nicotinic acetylcholine receptor subunit mRNA in developing cortex and hippocampus.
    Journal of chemical neuroanatomy, 2006, Volume: 32, Issue:2-4

    Topics: Acetylcholine; Aging; Animals; Animals, Newborn; Cerebral Cortex; gamma-Aminobutyric Acid; Gene Expr

2006
Opposite effects of a GABA(B) antagonist in two models of epileptic seizures in developing rats.
    Brain research bulletin, 2006, Dec-11, Volume: 71, Issue:1-3

    Topics: Action Potentials; Aging; Animals; Animals, Newborn; Cerebral Cortex; Convulsants; Disease Models, A

2006
An increase in in vivo release of LHRH and precocious puberty by posterior hypothalamic lesions in female rhesus monkeys (Macaca mulatta).
    American journal of physiology. Endocrinology and metabolism, 2007, Volume: 292, Issue:4

    Topics: Aging; Animals; Circadian Rhythm; Female; gamma-Aminobutyric Acid; Glutamic Acid; Gonadotropin-Relea

2007
Alteration in the GABAergic network of the prefrontal cortex in a potential animal model of psychosis.
    Journal of neural transmission (Vienna, Austria : 1996), 2007, Volume: 114, Issue:5

    Topics: Aging; Animals; Cell Differentiation; Disease Models, Animal; Dopamine Uptake Inhibitors; Environmen

2007
Maternal deprivation and early handling affect density of calcium binding protein-containing neurons in selected brain regions and emotional behavior in periadolescent rats.
    Neuroscience, 2007, Mar-16, Volume: 145, Issue:2

    Topics: Affective Symptoms; Aging; Animals; Anxiety Disorders; Behavior, Animal; Brain; Brain Chemistry; Cal

2007
GABAergic circuits and the stress hyporesponsive period in the rat: ontogeny of glutamic acid decarboxylase (GAD) 67 mRNA expression in limbic-hypothalamic stress pathways.
    Brain research, 2007, Mar-23, Volume: 1138

    Topics: Aging; Animals; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hypothalamus; Isoenzymes;

2007
Shunting and hyperpolarizing GABAergic inhibition in the high-potassium model of ictogenesis in the developing rat hippocampus.
    Hippocampus, 2007, Volume: 17, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Disease Models, Animal; Epilepsy; GABA Agonists; GABA Antagonists;

2007
GABAergic modulation of developing pedunculopontine nucleus.
    Neuroreport, 2007, Feb-12, Volume: 18, Issue:3

    Topics: Action Potentials; Aging; Animals; Baclofen; GABA Agonists; GABA-B Receptor Antagonists; gamma-Amino

2007
Susceptibility for homeostatic plasticity is down-regulated in parallel with maturation of the rat hippocampal synaptic circuitry.
    The Journal of physiology, 2007, Jun-01, Volume: 581, Issue:Pt 2

    Topics: Age Factors; Aging; Animals; Animals, Newborn; Down-Regulation; Excitatory Postsynaptic Potentials;

2007
Alterations in GABA(A) receptor expression in neonatal ventral hippocampal lesioned rats: comparison of prepubertal and postpubertal periods.
    Synapse (New York, N.Y.), 2007, Volume: 61, Issue:6

    Topics: Adaptation, Physiological; Aging; Animals; Animals, Newborn; Binding, Competitive; Bridged Bicyclo C

2007
17 beta-estradiol modulates GABAergic synaptic transmission and tonic currents during development in vitro.
    Neuropharmacology, 2007, Volume: 52, Issue:6

    Topics: Aging; Algorithms; Animals; Blotting, Western; Cells, Cultured; Electrophoresis, Polyacrylamide Gel;

2007
Androgen administration to aged male mice increases anti-anxiety behavior and enhances cognitive performance.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008, Volume: 33, Issue:5

    Topics: Age Factors; Aging; Analysis of Variance; Androgens; Animals; Anxiety; Avoidance Learning; Behavior,

2008
BMPR1a signaling determines numbers of oligodendrocytes and calbindin-expressing interneurons in the cortex.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, Jul-11, Volume: 27, Issue:28

    Topics: Aging; Animals; Animals, Newborn; Astrocytes; Basic Helix-Loop-Helix Transcription Factors; Bone Mor

2007
Molecular and cellular characterization of the age-related neuroinflammatory processes occurring in normal rat hippocampus: potential relation with the loss of somatostatin GABAergic neurons.
    Journal of neurochemistry, 2007, Volume: 103, Issue:3

    Topics: Aging; Animals; Cell Count; Cell Death; Down-Regulation; Encephalitis; gamma-Aminobutyric Acid; Gene

2007
Middle-aged female rats lack the dynamic changes in GAD(67) mRNA levels observed in young females on the day of a luteinising hormone surge.
    Journal of neuroendocrinology, 2007, Volume: 19, Issue:9

    Topics: Aging; Animals; Estrous Cycle; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hypothalamu

2007
Dynamic patterns of colocalization of calbindin, parvalbumin and GABA in subpopulations of mouse basolateral amygdalar cells during development.
    Journal of chemical neuroanatomy, 2008, Volume: 35, Issue:1

    Topics: Aging; Amygdala; Animals; Animals, Newborn; Brain Mapping; Calbindins; Calcium; Cell Differentiation

2008
Postnatal development and kinetics of [3H]gaboxadol binding in rat brain: in vitro homogenate binding and quantitative autoradiography.
    Brain research, 2007, Sep-19, Volume: 1170

    Topics: Aging; Animals; Animals, Newborn; Autoradiography; Binding, Competitive; Brain; Brain Chemistry; Flu

2007
Astrocytes may play a role in the etiology of absence epilepsy: a comparison between immature GAERS not yet expressing seizures and adults.
    Neurobiology of disease, 2007, Volume: 28, Issue:2

    Topics: Acetic Acid; Aging; Animals; Astrocytes; Brain; Cell Communication; Cell Differentiation; Disease Mo

2007
Changes of expression of genes related to the activity of the gonadotrophin-releasing hormone pulse generator in young versus middle-aged male rats.
    Journal of neuroendocrinology, 2007, Volume: 19, Issue:10

    Topics: Aging; Animals; gamma-Aminobutyric Acid; Gene Expression Profiling; Gene Expression Regulation; Glut

2007
Role of maternal corticosterone in the development and maturation of the aminoacidergic systems of the rat brain.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2007, Volume: 25, Issue:7

    Topics: Aging; Amino Acids; Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Corticost

2007
Mechanism of age-dependent susceptibility and novel treatment strategy in glutaric acidemia type I.
    The Journal of clinical investigation, 2007, Volume: 117, Issue:11

    Topics: Aging; Amino Acid Metabolism, Inborn Errors; Animals; Brain Diseases, Metabolic, Inborn; Child; Diet

2007
Increasing Interaction of amygdalar afferents with GABAergic interneurons between birth and adulthood.
    Cerebral cortex (New York, N.Y. : 1991), 2008, Volume: 18, Issue:7

    Topics: Aging; Amygdala; Animals; Efferent Pathways; gamma-Aminobutyric Acid; Interneurons; Male; Nerve Net;

2008
Impaired synaptogenesis and long-term modulation of behavior following postnatal elevation of GABA levels in mice.
    Neuropharmacology, 2008, Volume: 54, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Blotting, Western; Cerebral Cor

2008
Decreased proportion of GABA neurons accompanies age-related degradation of neuronal function in cat striate cortex.
    Brain research bulletin, 2008, Jan-31, Volume: 75, Issue:1

    Topics: Action Potentials; Aging; Analysis of Variance; Animals; Cats; Cell Count; gamma-Aminobutyric Acid;

2008
Early maturation of GABAergic synapses in mouse retinal ganglion cells.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2008, Volume: 26, Issue:2

    Topics: Aging; Animals; Cell Differentiation; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Am

2008
Taurine improves learning and retention in aged mice.
    Neuroscience letters, 2008, May-02, Volume: 436, Issue:1

    Topics: Administration, Oral; Aging; Animals; Dietary Supplements; gamma-Aminobutyric Acid; Learning; Mice;

2008
Despite GABAergic neurotransmission, GABAergic innervation does not compensate for the defect in glycine receptor postsynaptic aggregation in spastic mice.
    The European journal of neuroscience, 2008, Volume: 27, Issue:10

    Topics: Aging; Animals; Cell Differentiation; gamma-Aminobutyric Acid; Hypoglossal Nerve; Medulla Oblongata;

2008
Decline of the presynaptic network, including GABAergic terminals, in the aging suprachiasmatic nucleus of the mouse.
    Journal of biological rhythms, 2008, Volume: 23, Issue:3

    Topics: Aging; Animals; Base Sequence; DNA Primers; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Male;

2008
Early undernutrition and [3H]gamma-aminobutyric acid binding in rat brain.
    Journal of neurochemistry, 1984, Volume: 43, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Brain; Cerebral Cortex; Diazepam; gamma-Aminobutyric Acid; Hippoca

1984
Chemistry of mood and emotion.
    Annual review of psychology, 1980, Volume: 31

    Topics: Acetylcholine; Aging; Brain; Dopamine; Emotions; Enkephalins; Epinephrine; gamma-Aminobutyric Acid;

1980
Ontogeny of neurochemical markers for noradrenergic, GABAergic, and cholinergic neurons in neocortex lesioned with methylazoxymethanol acetate.
    Journal of neurochemistry, 1980, Volume: 34, Issue:6

    Topics: Acetylcholine; Aging; Animals; Azo Compounds; Cerebral Cortex; Choline; Choline O-Acetyltransferase;

1980
Aging and neurotransmitter systems.
    Advances in biochemical psychopharmacology, 1980, Volume: 23

    Topics: Adult; Aged; Aging; Brain; Catecholamines; Choline O-Acetyltransferase; Dementia; gamma-Aminobutyric

1980
Conversion of glucose to neurotransmitter amino acids in the brains of young and aging rats.
    Experimental gerontology, 1980, Volume: 15, Issue:6

    Topics: Age Factors; Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Female; gamma-Aminobutyric Acid; G

1980
Age-related alterations in neurotransmitter receptors: an electrophysiological and biochemical analysis.
    Neurobiology of aging, 1981,Spring, Volume: 2, Issue:1

    Topics: Acetylcholine; Aging; Animals; Evoked Potentials; gamma-Aminobutyric Acid; Hippocampus; Muscimol; Ne

1981
Neurotransmitter and carbohydrate metabolism during aging and mild hypoxia.
    Neurobiology of aging, 1981,Fall, Volume: 2, Issue:3

    Topics: Acetylcholine; Aging; Amino Acids; Animals; Brain; gamma-Aminobutyric Acid; Glucose; Hypoxia; Mice;

1981
Age-related changes in the glutamate metabolism of cerebral cortical slices from rats.
    Neurochemical research, 1982, Volume: 7, Issue:6

    Topics: Aging; Animals; Aspartic Acid; Carbon Dioxide; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates;

1982
Protein and taurine of maternal diets during the mouse neonatal period: permanent effects on cerebellar--brainstem amino acid levels in mature offspring.
    Neurochemical research, 1982, Volume: 7, Issue:8

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Brain Stem; Cerebellum; Dietary Proteins; Female; gam

1982
Effects of free fatty acids, ethanol and development on gamma-aminobutyric acid and glutamate fluxes in rat nerve endings.
    Biochemical pharmacology, 1982, Dec-15, Volume: 31, Issue:24

    Topics: Aging; Animals; Chemical Phenomena; Chemistry, Physical; Ethanol; Fatty Acids, Nonesterified; gamma-

1982
Biochemical development of the human brain. III. Benzodiazepine receptors, free gamma-aminobutyrate (GABA) and other amino acids.
    Journal of neuroscience research, 1982, Volume: 8, Issue:4

    Topics: Adult; Aged; Aging; Amino Acids; Aspartic Acid; Brain; Cerebellum; Female; Flunitrazepam; Frontal Lo

1982
Metabolism of the glutamate group of amino acids in rat brain as a function of age.
    Mechanisms of ageing and development, 1984, Volume: 24, Issue:2

    Topics: Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Energy Metabolism; Enzymes; gamma-Aminob

1984
High-affinity uptake of neurotransmitters in rat neostriatum: effects of aging.
    Journal of neurochemistry, 1984, Volume: 43, Issue:6

    Topics: Aging; Animals; Caudate Nucleus; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Glutamates; Glu

1984
The GABA/benzodiazepine receptor complex in the nervous system of a hypertensive strain of rat.
    Neurochemical research, 1984, Volume: 9, Issue:8

    Topics: Aging; Animals; Brain; Cerebellum; Cerebral Cortex; Flunitrazepam; gamma-Aminobutyric Acid; Glutamat

1984
Developmental changes of the GABA and polyamine systems in isolated neurons in cell culture.
    Developmental neuroscience, 1981, Volume: 4, Issue:3

    Topics: Aging; Amino Acids; Animals; Cerebral Cortex; Chick Embryo; DNA; gamma-Aminobutyric Acid; Putrescine

1981
Decreased CSF concentrations of homovanillic acid and gamma-aminobutyric acid in Alzheimer's disease. Age- or disease-related modifications?
    Archives of neurology, 1982, Volume: 39, Issue:11

    Topics: Age Factors; Aged; Aging; Alzheimer Disease; Brain Chemistry; Dementia; Female; gamma-Aminobutyric A

1982
Impairment of brain neurotransmitter receptors in aged rats.
    Mechanisms of ageing and development, 1980, Volume: 12, Issue:1

    Topics: Aging; Animals; Brain; Corpus Striatum; gamma-Aminobutyric Acid; Male; Olfactory Bulb; Pituitary Gla

1980
Effects of thyroid state on brain development: beta-adrenergic receptors and 5'-nucleotidase activity.
    Brain research, 1980, Oct-06, Volume: 198, Issue:2

    Topics: Aging; Animals; Brain; Dihydroalprenolol; Female; gamma-Aminobutyric Acid; Male; Nucleotidases; Rats

1980
Ontogeny of high-affinity GABA and benzodiazepine receptors in the rat cerebellum: an autoradiographic study.
    Brain research, 1981, Volume: 254, Issue:4

    Topics: Aging; Animals; Autoradiography; Cerebellum; Clonazepam; Female; Flunitrazepam; gamma-Aminobutyric A

1981
Ontogeny of 3H-diazepam binding sites in different rat brain area. Effect of GABA.
    Developmental neuroscience, 1981, Volume: 4, Issue:6

    Topics: Aging; Animals; Binding Sites; Brain; Cerebral Cortex; Diazepam; gamma-Aminobutyric Acid; Rats; Rats

1981
Functional interaction between benzodiazepine and GABA recognition sites in aged rats.
    Neurobiology of aging, 1981,Winter, Volume: 2, Issue:4

    Topics: Aging; Animals; Benzodiazepines; Brain; Cell Membrane; Diazepam; gamma-Aminobutyric Acid; Organ Spec

1981
gamma-Aminobutyric acid and benzodiazepine binding sites in audiogenic seizure-susceptible mice.
    Journal of neurochemistry, 1982, Volume: 39, Issue:3

    Topics: Acoustic Stimulation; Aging; Animals; Benzodiazepines; Brain; Cell Membrane; Flunitrazepam; gamma-Am

1982
[3H]GABA binding in developing rabbit retina.
    Neurochemical research, 1982, Volume: 7, Issue:4

    Topics: Aging; Animals; gamma-Aminobutyric Acid; Kinetics; Rabbits; Receptors, Cell Surface; Receptors, GABA

1982
Changes in neurotransmitter actions in the aged rat hippocampus.
    Neurobiology of aging, 1982,Summer, Volume: 3, Issue:2

    Topics: Acetylcholinesterase; Action Potentials; Aging; Animals; gamma-Aminobutyric Acid; Hippocampus; Neuro

1982
Age-related changes of benzodiazepine and GABA binding sites in the rat retina.
    Neurobiology of aging, 1982,Fall, Volume: 3, Issue:3

    Topics: Aging; Animals; Diazepam; Female; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Recepto

1982
Aging of the high affinity GABA transporter in synaptosomes from the hypothalamus of the rat.
    Experimental gerontology, 1983, Volume: 18, Issue:2

    Topics: Aging; Animals; gamma-Aminobutyric Acid; Hypothalamus; Kinetics; Male; Muridae; Receptors, Cell Surf

1983
Neurotransmitter receptors and aging.
    Journal of the American Geriatrics Society, 1984, Volume: 32, Issue:1

    Topics: Aging; Benzodiazepines; Central Nervous System; gamma-Aminobutyric Acid; Humans; Receptors, Adrenerg

1984
Chronic chlordiazepoxide treatment on adult and newborn rats: effect on the GABA-benzodiazepine receptor complex.
    Advances in biochemical psychopharmacology, 1983, Volume: 38

    Topics: Aging; Animals; Animals, Newborn; Chlordiazepoxide; Female; Flunitrazepam; gamma-Aminobutyric Acid;

1983
Ligand-binding studies on GABA receptors--relation to physiology and behavior.
    Neurochemical research, 1984, Volume: 9, Issue:3

    Topics: Aging; Analgesia; Animals; Behavior; Brain; Cardiovascular Physiological Phenomena; Epilepsy; gamma-

1984
Studies of the maturation of the visual system of the albino mouse.
    Archives d'anatomie, d'histologie et d'embryologie normales et experimentales, 1984, Volume: 67

    Topics: Aging; Animals; Dopamine; gamma-Aminobutyric Acid; Geniculate Bodies; Glutamates; Mice; Mice, Inbred

1984
Ontogeny of mechanisms which regulate light/dark differences in retinal dopamine synthesis.
    European journal of pharmacology, 1984, Jun-01, Volume: 101, Issue:3-4

    Topics: Adaptation, Physiological; Aging; Animals; Bicuculline; Darkness; Dihydroxyphenylalanine; Dopamine;

1984
Development of gamma-aminobutyric acid mediated inhibition of X cells of the cat lateral geniculate nucleus.
    The Journal of physiology, 1984, Volume: 357

    Topics: Aging; Animals; Bicuculline; Cats; gamma-Aminobutyric Acid; Geniculate Bodies; Neural Inhibition; Ne

1984
Transport of branched-chain amino acids in brain slices of developing and adult rats.
    Acta physiologica Scandinavica, 1984, Volume: 122, Issue:3

    Topics: Aging; Amino Acids; Amino Acids, Branched-Chain; Animals; Biological Transport; Brain; Extracellular

1984
Effect of hyperbaric oxygen on GABA transport in rat brain synaptosomes.
    Journal of neural transmission, 1983, Volume: 57, Issue:3

    Topics: Aging; Animals; Brain; Cerebral Cortex; Free Radicals; gamma-Aminobutyric Acid; Hyperbaric Oxygenati

1983
Is there a non-synaptic component in the K+-stimulated release of GABA in the developing rat cortex?
    Brain research, 1983, Volume: 312, Issue:2

    Topics: Aging; Animals; Calcium; Cerebral Cortex; Culture Techniques; gamma-Aminobutyric Acid; Neural Inhibi

1983
[Effect of aging on cerebrospinal fluid GABA level].
    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 1983, Volume: 20, Issue:6

    Topics: Adult; Aged; Aging; Animals; Brain; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Radi

1983
Development of hyperpolarizing inhibitory postsynaptic potentials and hyperpolarizing response to gamma-aminobutyric acid in rabbit hippocampus studied in vitro.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1984, Volume: 4, Issue:3

    Topics: Action Potentials; Aging; Animals; Animals, Newborn; Bicuculline; GABA Antagonists; gamma-Aminobutyr

1984
Growth hormone secretion of the neonatal rat pituitaries is stimulated by gamma-aminobutyric acid in vitro.
    Life sciences, 1984, Apr-16, Volume: 34, Issue:16

    Topics: Aging; Animals; Animals, Newborn; Baclofen; Bicuculline; Diazepam; Female; GABA Antagonists; gamma-A

1984
Central GABA mechanisms during postnatal development in the rat: neurochemical characteristics.
    Journal of neural transmission, 1984, Volume: 59, Issue:2

    Topics: 3-Mercaptopropionic Acid; Aging; Aminooxyacetic Acid; Animals; Brain; Female; gamma-Aminobutyric Aci

1984
Membrane properties and aging: in vivo and in vitro effects of ethanol on synaptosomal gamma-aminobutyric acid (GABA) release.
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 229, Issue:3

    Topics: Aging; Animals; Cerebral Cortex; Ethanol; gamma-Aminobutyric Acid; Male; Membranes; Mice; Mice, Inbr

1984
Effects of postnatal trimethyltin or triethyltin treatment on CNS catecholamine, GABA, and acetylcholine systems in the rat.
    Journal of neurochemistry, 1983, Volume: 40, Issue:5

    Topics: Acetylcholine; Aging; Animals; Brain; Choline; Dopamine; gamma-Aminobutyric Acid; Norepinephrine; Or

1983
Altered sensitivity of forebrain neurones to iontophoretically applied noradrenaline in aging rats.
    Neurobiology of aging, 1983,Spring, Volume: 4, Issue:1

    Topics: Aging; Animals; Cerebral Cortex; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Iontopho

1983
Potential therapies in aging and senile dementias.
    Annals of the New York Academy of Sciences, 1982, Volume: 396

    Topics: Acetylcholine; Aging; Alzheimer Disease; Animals; Cerebrovascular Circulation; Dementia; gamma-Amino

1982
Central nervous system gamma-aminobutyric acid activity in man. Relationship to age and sex as reflected in CSF.
    Archives of neurology, 1982, Volume: 39, Issue:4

    Topics: Adult; Aged; Aging; Central Nervous System; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Ag

1982
Aging of membrane transport mechanisms in the central nervous system. GABA transport in rat cortical synaptosomes.
    Experimental gerontology, 1982, Volume: 17, Issue:1

    Topics: Aging; Animals; Biological Transport; Brain; Dose-Response Relationship, Drug; gamma-Aminobutyric Ac

1982
Cerebral glutamic acid decarboxylase activity and gamma-aminobutyric acid concentrations in mice susceptible or resistant to audiogenic seizures.
    Journal of neurochemistry, 1982, Volume: 39, Issue:5

    Topics: Acoustic Stimulation; Aging; Animals; Brain; Carboxy-Lyases; gamma-Aminobutyric Acid; Glutamate Deca

1982
Kernicterus: enzymatic evidence for difference between the development of cholinergic and GABAergic innervations in the brain of the Gunn rat.
    Journal of neurochemistry, 1981, Volume: 37, Issue:4

    Topics: Acetylcholine; Aging; Animals; Brain; Carboxy-Lyases; Choline O-Acetyltransferase; gamma-Aminobutyri

1981
The development of glutamic acid decarboxylase in the visual cortex and the dorsal lateral geniculate nucleus of the rat.
    Brain research, 1981, Aug-03, Volume: 217, Issue:2

    Topics: Aging; Animals; Carboxy-Lyases; gamma-Aminobutyric Acid; Geniculate Bodies; Glutamate Decarboxylase;

1981
Postnatal changes of GABAergic and glutamatergic parameters.
    Brain research, 1981, Volume: 227, Issue:4

    Topics: Aging; Alanine; Amino Acids; Amino Acids, Cyclic; Animals; Carboxy-Lyases; Cerebral Cortex; Corpus S

1981
Biochemical development of the human brain. II. Some parameters of the GABA-ergic system.
    Developmental neuroscience, 1981, Volume: 4, Issue:3

    Topics: Adult; Aging; Cerebellum; Cerebral Cortex; DNA; Female; gamma-Aminobutyric Acid; Gestational Age; Gl

1981
Sulfur amino acid metabolism in the developing rhesus monkey brain: subcellular studies of taurine, cysteinesulfinic acid decarboxylase, gamma-aminobutyric acid, and glutamic acid decarboxylase.
    Journal of neurochemistry, 1981, Volume: 37, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Brain; Carboxy-Lyases; Female; Fetus; gamma-Aminobutyric Acid; Glu

1981
GABA stimulation of 3H-diazepam binding in aged mice.
    Life sciences, 1981, Aug-31, Volume: 29, Issue:9

    Topics: Aging; Animals; Brain; Diazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Male; Membr

1981
Developmental studies of the uptake of choline, GABA and dopamine by crude synaptosomal preparations after in vivo or in vitro lead treatment.
    Brain research, 1980, Apr-14, Volume: 187, Issue:2

    Topics: Aging; Animals; Biological Transport; Body Weight; Brain; Cerebral Cortex; Choline; Corpus Striatum;

1980
Effects of thyroid state on brain development: muscarinic acetylcholine and GABA receptors.
    Brain research, 1980, Oct-06, Volume: 198, Issue:2

    Topics: Acetylcholine; Aging; Animals; Brain; Female; gamma-Aminobutyric Acid; Male; Muscimol; Quinuclidinyl

1980
Age-related electrophysiological changes in rat cerebellum.
    Brain research, 1980, Nov-10, Volume: 201, Issue:1

    Topics: Aging; Amphetamine; Animals; Cerebellum; Fluphenazine; gamma-Aminobutyric Acid; Haloperidol; Locus C

1980
Ontogenic development of GABA recognition sites in different brain areas.
    Pharmacological research communications, 1980, Volume: 12, Issue:5

    Topics: Aging; Animals; Binding Sites; Brain; gamma-Aminobutyric Acid; Membranes; Rats

1980
Decreased monosynaptic GABAB-mediated inhibitory postsynaptic potentials in hippocampal CA1 pyramidal cells in the aged rat: pharmacological characterization and possible mechanisms.
    Journal of neurophysiology, 1995, Volume: 74, Issue:2

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; GABA Antagonists; gamma-Aminobutyric Acid; Hip

1995
Development of glycinergic and glutamatergic synaptic transmission in the auditory brainstem of perinatal rats.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:10

    Topics: Aging; Animals; Auditory Pathways; Brain Stem; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glyci

1995
Endogenous excitatory amino acid release from brain slices and astrocyte cultures evoked by trimethyltin and other neurotoxic agents.
    Neurochemical research, 1995, Volume: 20, Issue:7

    Topics: Aging; Animals; Aspartic Acid; Astrocytes; Brain; Cells, Cultured; Cerebral Cortex; Excitatory Amino

1995
An oriented framework of neuronal processes in the ventral lateral geniculate nucleus of the rat demonstrated by NADPH diaphorase histochemistry and GABA immunocytochemistry.
    Neuroscience, 1994, Volume: 60, Issue:2

    Topics: Aging; Amino Acid Oxidoreductases; Animals; Brain; gamma-Aminobutyric Acid; Geniculate Bodies; Histo

1994
Systemic or local administration of azide produces striatal lesions by an energy impairment-induced excitotoxic mechanism.
    Experimental neurology, 1994, Volume: 129, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine Triphosphate; Aging; Animals; Azides; Biogenic Amines; Cor

1994
Acetylcholinesterase-containing intrinsic neurons in the rat main olfactory bulb: cytological and neurochemical features.
    The European journal of neuroscience, 1994, Sep-01, Volume: 6, Issue:9

    Topics: Acetylcholinesterase; Aging; Animals; Animals, Newborn; gamma-Aminobutyric Acid; Histocytochemistry;

1994
Glycine- and GABA-activated currents in identified glial cells of the developing rat spinal cord slice.
    The European journal of neuroscience, 1995, Jun-01, Volume: 7, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Astrocytes; Chlorides; Electrophysiology; gamma-Aminobutyric Acid;

1995
Astroglial cells express large amounts of GABAA receptor proteins in mature brain.
    Journal of neurochemistry, 1995, Volume: 65, Issue:5

    Topics: Aging; Animals; Astrocytes; Benzodiazepines; Binding Sites; Brain; Cattle; Cells, Cultured; gamma-Am

1995
Age-dependent neurotoxicity of striatal lesions produced by aminooxyacetic acid: quantitative in vitro 1H NMR spectroscopic studies.
    Journal of neurochemistry, 1995, Volume: 65, Issue:3

    Topics: Aging; Alanine; Animals; Aspartic Acid; Corpus Striatum; Creatine; Energy Metabolism; gamma-Aminobut

1995
Reversal of a muscle response to GABA during C. elegans male development.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:9

    Topics: Aging; Anal Canal; Animals; Caenorhabditis elegans; Constipation; Defecation; gamma-Aminobutyric Aci

1995
Cholinergic and GABAergic neurons in the nucleus basalis region of young and aged rats.
    Neuroscience, 1995, Volume: 67, Issue:3

    Topics: Aging; Animals; Antibodies; Carboxy-Lyases; Cell Count; Cell Death; Cholinergic Fibers; gamma-Aminob

1995
Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate.
    Journal of neurochemistry, 1993, Volume: 61, Issue:3

    Topics: Adenosine Triphosphate; Aging; Animals; Corpus Striatum; Dizocilpine Maleate; gamma-Aminobutyric Aci

1993
Plasma vigabatrin enantiomer ratios in adults and children.
    Clinical and experimental neurology, 1993, Volume: 30

    Topics: Aged; Aged, 80 and over; Aging; Anticonvulsants; Child; Child, Preschool; Chromatography, Gas; Femal

1993
Developmental kinetics of GAD family mRNAs parallel neurogenesis in the rat spinal cord.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:4

    Topics: Aging; Alternative Splicing; Animals; Base Sequence; DNA Primers; Embryonic and Fetal Development; g

1995
The effects of chronic treatment with N-tert-butyl-alpha-phenylnitrone on cerebellar noradrenergic receptor function in aged F344 rats.
    Brain research, 1994, Oct-17, Volume: 660, Issue:2

    Topics: Aging; Animals; Cerebellum; Cyclic N-Oxides; gamma-Aminobutyric Acid; Isoproterenol; Male; Membrane

1994
Aging-associated changes in the pharmacological properties of the benzodiazepine (omega) receptor isotypes in the rat hippocampus.
    Journal of neurochemistry, 1995, Volume: 64, Issue:2

    Topics: Aging; Animals; Binding Sites; gamma-Aminobutyric Acid; Hippocampus; Isomerism; Male; Membranes; Pyr

1995
Postnatal ontogeny of GABAB binding in rat brain.
    Neuroscience, 1994, Volume: 62, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Autoradiography; Binding, Competitive; Brain; GABA-B Receptor Anta

1994
GABAergic and developmental influences on homosynaptic LTD and depotentiation in rat hippocampus.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:2

    Topics: Aging; Animals; Electric Stimulation; Electrophysiology; GABA-A Receptor Antagonists; GABA-B Recepto

1995
Transient expression of a novel type of GABA response in rat CA3 hippocampal neurones during development.
    The Journal of physiology, 1994, Nov-01, Volume: 480 ( Pt 3)

    Topics: Aging; Animals; Animals, Newborn; Baclofen; Bicuculline; gamma-Aminobutyric Acid; Hippocampus; Neuro

1994
Enhancement of GABA-activated membrane currents in aged Fischer 344 rat basal forebrain neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:3 Pt 2

    Topics: Action Potentials; Aging; Animals; Bicuculline; Drug Synergism; gamma-Aminobutyric Acid; Ion Channel

1995
Influence of hypoxia on excitation and GABAergic inhibition in mature and developing rat neocortex.
    Experimental brain research, 1993, Volume: 97, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Cell Hypoxia; Ele

1993
Enhanced aspartate release related to epilepsy in (EL) mice.
    Journal of neurochemistry, 1994, Volume: 63, Issue:2

    Topics: Aging; Animals; Aspartic Acid; Epilepsy; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippoca

1994
Age-related changes in brainstem auditory neurotransmitters: measures of GABA and acetylcholine function.
    Hearing research, 1994, Jun-15, Volume: 77, Issue:1-2

    Topics: 4-Aminobutyrate Transaminase; Acetylcholine; Aging; Animals; Aspartic Acid; Auditory Pathways; Biolo

1994
Age-related changes of GABA-activated chloride channel properties in brain cortex synaptic plasma membrane: evidence for phospholipase involvement.
    Journal of neurochemistry, 1994, Volume: 63, Issue:4

    Topics: Aging; Animals; Arachidonic Acid; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic

1994
Allosteric modulation of [35S]TBPS-binding in the cerebral cortex of the rat during postnatal development.
    Brain research. Developmental brain research, 1994, Jul-15, Volume: 80, Issue:1-2

    Topics: Aging; Allosteric Regulation; Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compo

1994
Modulation of GABA-mediated synaptic transmission by endogenous zinc in the immature rat hippocampus in vitro.
    The Journal of physiology, 1994, Jul-01, Volume: 478 ( Pt 1)

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Aging; Alanine; Animals; Animals, Newborn;

1994
Cajal-Retzius neurons identified by GABA immunohistochemistry in layer I of the rat cerebral cortex.
    Neuroscience research, 1994, Volume: 20, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Cerebral Cortex; Embryonic and Fetal Development; Fetus; gamma-Ami

1994
The astrocyte response to gamma-aminobutyric acid attenuates with age in the rat optic nerve.
    Proceedings. Biological sciences, 1994, Oct-22, Volume: 258, Issue:1351

    Topics: Aging; Animals; Astrocytes; Bicuculline; gamma-Aminobutyric Acid; In Vitro Techniques; Membrane Pote

1994
Developmental changes in the distribution of gamma-aminobutyric acid-immunoreactive neurons in the embryonic chick lumbosacral spinal cord.
    The Journal of comparative neurology, 1994, May-08, Volume: 343, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Chick Embryo; Embryonic and Fetal Development; gamma-Aminobutyric

1994
Nitric oxide production and neurotoxicity mediated by activated microglia from human versus mouse brain.
    The Journal of infectious diseases, 1994, Volume: 170, Issue:2

    Topics: Aged; Aging; Animals; Animals, Newborn; Arginine; Brain; Cells, Cultured; gamma-Aminobutyric Acid; H

1994
Regulation of D-aspartate release by glutamate and GABA receptors in cerebral cortical slices from developing and ageing mice.
    Neuroscience, 1994, Volume: 60, Issue:1

    Topics: Aging; Animals; Aspartic Acid; Cerebellum; Cerebral Cortex; Excitatory Amino Acid Antagonists; Femal

1994
Sexual differences in the effect of the GABAergic system on LH secretion and in the hypothalamic ontogenesis of GABAA receptors in prepubertal rats.
    Brain research, 1994, May-23, Volume: 646, Issue:2

    Topics: Aging; Aminooxyacetic Acid; Animals; Female; gamma-Aminobutyric Acid; Hypothalamus; Luteinizing Horm

1994
Plasticity of astroglial glutamate and gamma-aminobutyric acid uptake in cell cultures derived from postnatal mouse cerebellum.
    Journal of neurochemistry, 1993, Volume: 60, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Astrocytes; Autoradiography; Binding Sites; Cells, Cultured; Cereb

1993
Synaptic neurochemistry of human striatum during development: changes in sudden infant death syndrome.
    Journal of neurochemistry, 1993, Volume: 60, Issue:6

    Topics: Acetylcholinesterase; Aging; Biogenic Amines; Biomarkers; Carnitine O-Acetyltransferase; Choline O-A

1993
Neocortical, hippocampal and septal parvalbumin- and somatostatin-containing neurons in young and aged rats: correlation with passive avoidance and water maze performance.
    Neuroscience, 1993, Volume: 53, Issue:2

    Topics: Aging; Animals; Avoidance Learning; Brain Chemistry; Cerebral Cortex; Dendrites; gamma-Aminobutyric

1993
Neurotrophic effects of cAMP generating systems on central noradrenergic neurons.
    Brain research, 1993, Jun-18, Volume: 614, Issue:1-2

    Topics: Adenylyl Cyclases; Aging; Animals; Calcium; Cell Differentiation; Cell Survival; Culture Media; Cycl

1993
Hippocampal changes in developing postnatal mice following intrauterine exposure to domoic acid.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1993, Volume: 13, Issue:10

    Topics: Aging; Analysis of Variance; Animals; Brain; Calcium; Cerebral Cortex; Dose-Response Relationship, D

1993
Developmental regulation of voltage-gated K+ channel and GABAA receptor expression in Bergmann glial cells.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1994, Volume: 14, Issue:5 Pt 1

    Topics: Aging; Animals; Barium; Bicuculline; Cerebellum; Fluorescent Antibody Technique; gamma-Aminobutyric

1994
Modulation of 35S-TBPS binding by GABAergic drugs in the cerebral cortex of newborn and adult rats.
    Brain research bulletin, 1993, Volume: 32, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds,

1993
Cholinergic and non-cholinergic synaptic mechanisms in the aged rat hippocampus.
    Annals of the New York Academy of Sciences, 1993, Sep-24, Volume: 695

    Topics: Aging; Animals; gamma-Aminobutyric Acid; Hippocampus; Male; Membrane Potentials; Neurons; Pyramidal

1993
Modulation of the developing rat sympathetic GABAA receptor by Zn++, benzodiazepines, barbiturates and ethanol.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:3

    Topics: Aging; Animals; Barbiturates; Benzodiazepines; Bicuculline; Diazepam; Ethanol; GABA-A Receptor Antag

1993
Postnatal development and GABA allosteric modulation of benzodiazepine receptor binding in the vitamin B-6 deficient rat brain.
    Neurochemical research, 1993, Volume: 18, Issue:12

    Topics: Aging; Allosteric Regulation; Animals; Brain; Cell Membrane; Cerebellum; Cerebral Cortex; Female; Fl

1993
Chronic infusions of GABA into the medial prefrontal cortex induce spatial alternation deficits in aged rats.
    Behavioural brain research, 1993, Oct-21, Volume: 57, Issue:1

    Topics: Aging; Animals; Appetitive Behavior; Attention; Brain Mapping; Discrimination Learning; gamma-Aminob

1993
The effects of ethanol on gamma-aminobutyric acid-induced depressions of cerebellar Purkinje neurons: influence of beta adrenergic receptor action in young and aged Fischer 344 rats.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:2

    Topics: Aging; Animals; Drug Synergism; Ethanol; gamma-Aminobutyric Acid; Isoproterenol; Male; Purkinje Cell

1993
The attenuation of GABA sensitivity in the maturing myelin-deficient rat optic nerve.
    Brain research. Developmental brain research, 1993, Mar-19, Volume: 72, Issue:1

    Topics: Action Potentials; Aging; Animals; Bicuculline; gamma-Aminobutyric Acid; In Vitro Techniques; Muscim

1993
Differential properties of type I and type II benzodiazepine receptors in mammalian CNS neurones.
    British journal of pharmacology, 1993, Volume: 109, Issue:3

    Topics: Aging; Animals; Benzothiepins; Central Nervous System; Cerebral Cortex; Diazepam; gamma-Aminobutyric

1993
Differential ontogenesis of presynaptic and postsynaptic GABAB inhibition in rat somatosensory cortex.
    Journal of neurophysiology, 1993, Volume: 70, Issue:1

    Topics: Aging; Animals; Culture Techniques; Evoked Potentials, Somatosensory; gamma-Aminobutyric Acid; Inter

1993
Motor learning deficits in aged rats are correlated with loss of cerebellar noradrenergic function.
    Brain research, 1993, Aug-20, Volume: 620, Issue:1

    Topics: Aging; Animals; Cerebellum; Drug Synergism; Electrophysiology; gamma-Aminobutyric Acid; Isoprotereno

1993
GABA transporter mRNA: in vitro expression and quantitation in neonatal rat and postmortem human brain.
    Neurochemistry international, 1993, Volume: 22, Issue:3

    Topics: Adult; Aging; Animals; Animals, Newborn; Base Sequence; Brain; Cadaver; Carrier Proteins; Cells, Cul

1993
GABAergic effects on respiratory neuronal discharge during opossum development.
    The American journal of physiology, 1993, Volume: 264, Issue:2 Pt 2

    Topics: Aging; Animals; Animals, Suckling; Bicuculline; Electrophysiology; gamma-Aminobutyric Acid; Injectio

1993
Behavioral state dependence of homo- and hetero-synaptic modulation of dentate gyrus excitability.
    Experimental brain research, 1993, Volume: 93, Issue:1

    Topics: Aging; Animals; Atropine; Behavior, Animal; Electric Stimulation; Electroencephalography; gamma-Amin

1993
Dopamine--glutamate--GABA interactions and ageing: studies in the striatum of the conscious rat.
    The European journal of neuroscience, 1995, Nov-01, Volume: 7, Issue:11

    Topics: Aging; Animals; Apomorphine; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Male

1995
GABAA receptor binding in the aging rat inferior colliculus.
    Neuroscience, 1996, Volume: 73, Issue:2

    Topics: Aged; Aging; Animals; Autoradiography; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic

1996
Suicide and aging. II: The psychobiological interface.
    International psychogeriatrics, 1995,Summer, Volume: 7, Issue:2

    Topics: Adolescent; Adult; Age Factors; Aged; Aging; Binding, Competitive; Brain; Dopamine; Female; gamma-Am

1995
Quantitative aspects of synaptogenesis in the rat barrel field cortex with special reference to GABA circuitry.
    The Journal of comparative neurology, 1996, Sep-23, Volume: 373, Issue:3

    Topics: Aging; Analysis of Variance; Animals; Cell Count; Female; gamma-Aminobutyric Acid; Immunohistochemis

1996
The effects of aging on cerebellar beta-adrenergic receptor activation and motor learning in female F344 rats.
    Neuroscience letters, 1996, Sep-20, Volume: 216, Issue:1

    Topics: Action Potentials; Adrenergic beta-Agonists; Aging; Animals; Cerebellum; Female; gamma-Aminobutyric

1996
The GABAergic control of gonadotropin-releasing hormone secretion in male rats during sexual maturation involves effects on hypothalamic excitatory and inhibitory amino acid systems.
    Neuroendocrinology, 1996, Volume: 64, Issue:4

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; GABA Agonists; GABA Antagonists; gamma-Aminobutyric A

1996
Regional and developmental variations in metabolite concentration in the rat brain and eye: a study using 1H NMR spectroscopy and high performance liquid chromatography.
    Neurochemical research, 1996, Volume: 21, Issue:9

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Stem; Cerebellum; Cerebra

1996
Electrophysiological correlates of seizure sensitivity in the dentate gyrus of epileptic juvenile and adult gerbils.
    Journal of neurophysiology, 1996, Volume: 76, Issue:4

    Topics: Aging; Animals; Cell Count; Dentate Gyrus; Electric Stimulation; Epilepsy; gamma-Aminobutyric Acid;

1996
GABAA receptor function in developing rat thalamic reticular neurons: whole cell recordings of GABA-mediated currents and modulation by clonazepam.
    Journal of neurophysiology, 1996, Volume: 76, Issue:4

    Topics: Aging; Analysis of Variance; Animals; Chloride Channels; Clonazepam; GABA Modulators; gamma-Aminobut

1996
Responses of young and aged Fischer 344 rat inferior colliculus neurons to binaural tonal stimuli.
    Hearing research, 1996, Volume: 100, Issue:1-2

    Topics: Acoustic Stimulation; Aging; Analysis of Variance; Animals; Auditory Threshold; gamma-Aminobutyric A

1996
Age-related modifications on the GABAA receptor binding properties from Wistar rat prefrontal cortex.
    Brain research, 1996, Oct-28, Volume: 738, Issue:1

    Topics: Aging; Animals; Benzodiazepines; Binding Sites; Flunitrazepam; GABA Agonists; GABA Modulators; gamma

1996
Different mechanisms regulate IPSC kinetics in early postnatal and juvenile hippocampal granule cells.
    Journal of neurophysiology, 1996, Volume: 76, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Electric Stimulation; Evoked Potentials; Female; gamma-Aminobutyri

1996
A pacemaker current in dye-coupled hilar interneurons contributes to the generation of giant GABAergic potentials in developing hippocampus.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Feb-15, Volume: 17, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Cations; Electric Conductivity; Electrophysiology; gamma-Aminobuty

1997
Granule cell disinhibition in dentate gyrus of genetically seizure susceptible El mice.
    Brain research, 1997, Jan-16, Volume: 745, Issue:1-2

    Topics: Aging; Animals; Anticonvulsants; Bicuculline; Chromatography, High Pressure Liquid; Dentate Gyrus; E

1997
Functional alteration of the GABAB receptor in the brain of spontaneously hypertensive rats.
    Clinical and experimental pharmacology & physiology. Supplement, 1995, Volume: 22, Issue:1

    Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Aging; Animals; Blood Pressure; Brain; Brain Chemist

1995
Excitatory and trophic action of GABA and related substances in newborn mice and organotypic cerebellar culture.
    Developmental neuroscience, 1997, Volume: 19, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Bicuculline; Calcium; Cell Count; Cerebellum; Diazepam; GABA Agent

1997
Identifying monoaminergic, GABAergic, and cholinergic characteristics in immortalized neuronal cell lines.
    Neurochemical research, 1997, Volume: 22, Issue:5

    Topics: Acetylcholine; Aging; Animals; Animals, Newborn; Aspartic Acid; Brain; Cell Line, Transformed; Cell

1997
The neuronal system of the saccus vasculosus of trout (Salmo trutta fario and Oncorhynchus mykiss): an immunocytochemical and nerve tracing study.
    Cell and tissue research, 1997, Volume: 288, Issue:3

    Topics: Aging; Animals; Axonal Transport; Brain; Carbocyanines; Cerebrospinal Fluid; Embryo, Nonmammalian; F

1997
Plasticity of the auditory brainstem: effects of cochlear ablation on GAP-43 immunoreactivity in the rat.
    The Journal of comparative neurology, 1997, May-26, Volume: 382, Issue:1

    Topics: Aging; Animals; Brain Stem; Cochlea; Cochlear Nucleus; Female; Functional Laterality; gamma-Aminobut

1997
Cerebrospinal fluid gamma-aminobutyric acid and glutamate values in dogs with epilepsy.
    American journal of veterinary research, 1997, Volume: 58, Issue:5

    Topics: Aging; Animals; Body Weight; Chromatography, High Pressure Liquid; Dog Diseases; Dogs; Epilepsy; Fem

1997
Age-related deficits in the cerebellar beta adrenergic signal transduction cascade in Fischer 344 rats.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 281, Issue:2

    Topics: Aging; Animals; Cerebellum; Colforsin; Cyclic AMP; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred

1997
Cleft palate and decreased brain gamma-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase.
    Proceedings of the National Academy of Sciences of the United States of America, 1997, Jun-10, Volume: 94, Issue:12

    Topics: Aging; Animals; Brain; Cerebral Cortex; Cleft Palate; gamma-Aminobutyric Acid; Genotype; Glutamate D

1997
Effect of age on synthesis of the GABAergic steroids 5-alpha-pregnane-3,20-dione and 5-alpha-pregnane-3-alpha-ol-20-one in rat cortex in vitro.
    Journal of neural transmission (Vienna, Austria : 1996), 1997, Volume: 104, Issue:2-3

    Topics: 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); 3-Hydroxysteroid Dehydrogenases; 5-alpha-Dihydrop

1997
Is hypothalamic GABA involved in immune function in relation to dietary protein during aging?
    Neurochemical research, 1997, Volume: 22, Issue:9

    Topics: Aging; Animals; Antibody Formation; Cell Survival; Dietary Proteins; gamma-Aminobutyric Acid; Glutam

1997
Aging attenuates diurnal variation in hamster locomotion, anxiolysis and GABA turnover.
    Neuroscience letters, 1997, Sep-12, Volume: 233, Issue:1

    Topics: Age Factors; Aging; Animals; Anxiety; Circadian Rhythm; Cricetinae; gamma-Aminobutyric Acid; Locomot

1997
Reserpine effects on neurotransmitters in chick heart during growth.
    Journal of physiology, Paris, 1997, Volume: 91, Issue:2

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Chickens; gamma-Aminobutyric Acid; Inj

1997
Dopamine axons in primate prefrontal cortex: specificity of distribution, synaptic targets, and development.
    Advances in pharmacology (San Diego, Calif.), 1998, Volume: 42

    Topics: Aging; Animals; Axons; Carrier Proteins; Dendrites; Dopamine; Dopamine Plasma Membrane Transport Pro

1998
Neurochemical development of the degenerating rat retina.
    The Journal of comparative neurology, 1997, Nov-10, Volume: 388, Issue:1

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Arginine; Aspartic Acid; gamma-Aminobutyric Acid; Glu

1997
Expression of two forms of glutamic acid decarboxylase (GAD67 and GAD65) during postnatal development of the cat visual cortex.
    Brain research. Developmental brain research, 1997, Nov-12, Volume: 103, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Blotting, Western; Cats; gamma-Aminobutyric Acid; Gene Expression

1997
Involvement of gamma amino butyric acid (GABA) in the postnatal function of the GnRH pulse generator as determined on the basis of GnRH and GnRH-receptor gene expression in the hypothalamus and the pituitary.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 1997, Volume: 105, Issue:6

    Topics: Aging; Animals; Bicuculline; Female; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression; Gon

1997
Ontogeny of GABA-immunoreactive cells in the prefrontal and occipital cortices of the primate.
    Journal fur Hirnforschung, 1997, Volume: 38, Issue:4

    Topics: Aging; Animals; Cell Count; Cell Death; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Immunohist

1997
Age-related development of gamma-aminobutyric acid (GABA)B receptor functions in various brain regions of spontaneously hypertensive rats.
    Neurochemical research, 1998, Volume: 23, Issue:1

    Topics: Adenylyl Cyclases; Aging; Animals; Baclofen; Brain; Corpus Striatum; Cyclic AMP; GABA Agonists; gamm

1998
Developmental profile and synaptic origin of early network oscillations in the CA1 region of rat neonatal hippocampus.
    The Journal of physiology, 1998, Feb-15, Volume: 507 ( Pt 1)

    Topics: Aging; Animals; Animals, Newborn; Calcium; Electrophysiology; gamma-Aminobutyric Acid; Hippocampus;

1998
Ontogenesis of presynaptic GABAB receptor-mediated inhibition in the CA3 region of the rat hippocampus.
    Journal of neurophysiology, 1998, Volume: 79, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Animals, Newborn;

1998
Modulation of calcium by inhibitory systems in the developing auditory midbrain.
    Neuroscience, 1998, Volume: 83, Issue:4

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Aging; Animals

1998
Hypothalamic GABA-ergic activity and T-cell proliferation in aged mammal: effect of dietary protein.
    Neurochemistry international, 1998, Volume: 32, Issue:2

    Topics: 4-Aminobutyrate Transaminase; Aging; Animals; Diet, Protein-Restricted; Dietary Proteins; gamma-Amin

1998
Release of endogenous glutamate, aspartate, GABA, and taurine from hippocampal slices from adult and developing mice under cell-damaging conditions.
    Neurochemical research, 1998, Volume: 23, Issue:4

    Topics: Aging; Animals; Aspartic Acid; Brain Ischemia; Female; gamma-Aminobutyric Acid; Glutamic Acid; Hippo

1998
Age-dependent and cell class-specific modulation of retinal ganglion cell bursting activity by GABA.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, May-15, Volume: 18, Issue:10

    Topics: Aging; Animals; Animals, Newborn; Bicuculline; Electrophysiology; Female; Ferrets; GABA Antagonists;

1998
A developmental shift from GABAergic to glycinergic transmission in the central auditory system.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Jun-15, Volume: 18, Issue:12

    Topics: Aging; Animals; Auditory Pathways; Baclofen; Brain; Electric Conductivity; GABA Agonists; gamma-Amin

1998
Anticonvulsant effect of progabide in rats during ontogenesis.
    Physiological research, 1997, Volume: 46, Issue:1

    Topics: Aging; Animals; Anticonvulsants; Behavior, Animal; Convulsants; gamma-Aminobutyric Acid; Male; Penty

1997
Anticonvulsant effect of SL 75 102 in adult and immature rats.
    Physiological research, 1997, Volume: 46, Issue:1

    Topics: Aging; Animals; Anticonvulsants; gamma-Aminobutyric Acid; Pentylenetetrazole; Rats; Seizures

1997
Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Oct-01, Volume: 18, Issue:19

    Topics: Aging; Animals; Antioxidants; Body Weight; Brain Chemistry; Calcium Radioisotopes; Cognition Disorde

1998
Effect of neonatal exposure to monosodium L-glutamate on regional GABA release during postnatal development.
    Neurochemistry international, 1998, Volume: 33, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Brain; Cerebral Cortex; Corpus Striatum; gamma-Aminobutyric Acid;

1998
[D-cycloserine is active in the adult mouse and inactive in the aged mouse, in the forced swim test].
    Annales pharmaceutiques francaises, 1998, Volume: 56, Issue:5

    Topics: Aging; Animals; Avoidance Learning; Cycloserine; GABA Agonists; gamma-Aminobutyric Acid; Imipramine;

1998
Aging decreases the sensitivity of the GABA carrier to propofol and etomidate.
    British journal of anaesthesia, 1998, Volume: 81, Issue:2

    Topics: Aging; Anesthetics, Intravenous; Animals; Cell Culture Techniques; Etomidate; gamma-Aminobutyric Aci

1998
Impaired function of bipolar cells in the Royal College of Surgeons rat.
    Acta anatomica, 1998, Volume: 162, Issue:2-3

    Topics: Aging; Animals; Cells, Cultured; Electroretinography; gamma-Aminobutyric Acid; Interneurons; Magnesi

1998
Olfactory bulb development is altered in small-eye (Sey) mice.
    The Journal of comparative neurology, 1998, Dec-21, Volume: 402, Issue:3

    Topics: Aging; Animals; Calbindin 2; Calbindins; DNA-Binding Proteins; Dopamine; Eye Proteins; gamma-Aminobu

1998
Alteration of NMDA receptor-mediated synaptic responses in CA1 area of the aged rat hippocampus: contribution of GABAergic and cholinergic deficits.
    Hippocampus, 1998, Volume: 8, Issue:6

    Topics: Acetylcholine; Aging; Animals; Antibodies, Monoclonal; Cholinergic Agents; Denervation; Excitatory P

1998
Somatic recording of GABAergic autoreceptor current in cerebellar stellate and basket cells.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999, Mar-01, Volume: 19, Issue:5

    Topics: Action Potentials; Aging; Animals; Autoreceptors; Axons; Bicuculline; Cadmium; Calcium Channels; Cer

1999
Effects of age on GABA turnover rates in specific hypothalamic areas in female rats.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 1999, Volume: 107, Issue:1

    Topics: Aging; Animals; Diestrus; Estrus; Female; gamma-Aminobutyric Acid; Gonadotropin-Releasing Hormone; H

1999
[Interaction of neurotransmitters in specific circuits of the brain].
    Anales de la Real Academia Nacional de Medicina, 1998, Volume: 115, Issue:3

    Topics: Aging; Animals; Brain; Brain Diseases; Cerebral Cortex; Dopamine; gamma-Aminobutyric Acid; Glutamic

1998
Developmental sex differences in amino acid neurotransmitter levels in hypothalamic and limbic areas of rat brain.
    Neuroscience, 1999, Volume: 90, Issue:4

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Female; gamma-Aminobutyric Acid; Gluta

1999
Expression of GABA transporter subtypes (GAT1, GAT3) in the developing rabbit retina.
    Acta ophthalmologica Scandinavica, 1999, Volume: 77, Issue:3

    Topics: Aging; Animals; Carrier Proteins; Fluorescent Antibody Technique; GABA Plasma Membrane Transport Pro

1999
Low expression of the ClC-2 chloride channel during postnatal development: a mechanism for the paradoxical depolarizing action of GABA and glycine in the hippocampus.
    Proceedings. Biological sciences, 1999, Jun-22, Volume: 266, Issue:1425

    Topics: Aging; Amino Acid Sequence; Animals; Animals, Newborn; Chloride Channels; Cloning, Molecular; Female

1999
Age-related changes in GABA(A) receptor subunit composition and function in rat auditory system.
    Neuroscience, 1999, Volume: 93, Issue:1

    Topics: Aging; Animals; Blotting, Western; Chlorides; gamma-Aminobutyric Acid; Hearing; In Situ Hybridizatio

1999
Levels of amino acid neurotransmitters during mouse cerebellar neurogenesis and in histotypic cerebellar cultures.
    Developmental neuroscience, 1999, Volume: 21, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Cells, Cultured; Cerebellum; Chromatography, High P

1999
Subpopulations of GABAergic and non-GABAergic rat dorsal horn neurons express Ca2+-permeable AMPA receptors.
    The European journal of neuroscience, 1999, Volume: 11, Issue:8

    Topics: Aging; Animals; Calcium; Calcium-Binding Proteins; Cobalt; gamma-Aminobutyric Acid; Glycine; Immunoh

1999
Increased glutathione levels in neurochemically identified fibre systems in the aged rat lumbar motor nuclei.
    The European journal of neuroscience, 1999, Volume: 11, Issue:8

    Topics: Aging; Animals; Axons; gamma-Aminobutyric Acid; Glutamic Acid; Glutathione; Glycine; Immunohistochem

1999
Effect of increased brain GABA concentrations on breathing in unanesthetized newborn rabbits.
    Biology of the neonate, 1999, Volume: 76, Issue:3

    Topics: 4-Aminobutyrate Transaminase; Aging; Aminooxyacetic Acid; Animals; Animals, Newborn; Brain; Brain St

1999
Age-related reductions in the activities of antioxidant enzymes in the rat inferior colliculus.
    Hearing research, 1999, Volume: 135, Issue:1-2

    Topics: Aging; Alkaline Phosphatase; Animals; Antioxidants; Auditory Pathways; Catalase; gamma-Aminobutyric

1999
GABA(A) receptor in growth cones: the outline of GABA(A) receptor-dependent signaling in growth cones is applicable to a variety of alpha-subunit species.
    Journal of neuroscience research, 1999, Nov-01, Volume: 58, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Calcium; Cerebral Cortex; Chlorides; Diazepam; Fetus; gamma-Aminob

1999
Differential bicuculline-induced epileptogenesis in rat neonatal, juvenile and adult CA3 pyramidal neurons in vitro.
    Brain research. Developmental brain research, 1999, Oct-20, Volume: 117, Issue:1

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Aging; Animals; Animals, Newborn; Bicuculli

1999
Effects of aging on the interaction between glutamate, dopamine, and GABA in striatum and nucleus accumbens of the awake rat.
    Journal of neurochemistry, 1999, Volume: 73, Issue:5

    Topics: Aging; Animals; Corpus Striatum; Dicarboxylic Acids; Dopamine; Drug Interactions; Excitatory Amino A

1999
Developmental sex differences in calbindin-D(28K) and calretinin immunoreactivity in the neonatal rat hypothalamus.
    Journal of neurobiology, 2000, Feb-15, Volume: 42, Issue:3

    Topics: Aging; Analysis of Variance; Animals; Animals, Newborn; Calbindin 2; Calbindins; Female; gamma-Amino

2000
In vitro proton and phosphorus NMR spectroscopic analysis of murine (C57Bl/6J) brain development.
    NMR in biomedicine, 1999, Volume: 12, Issue:7

    Topics: Aging; Animals; Aspartic Acid; Brain; Brain Chemistry; Chloroform; Creatine; gamma-Aminobutyric Acid

1999
Effects of aging on cerebellar noradrenergic function and motor learning: nutritional interventions.
    Mechanisms of ageing and development, 1999, Volume: 111, Issue:2-3

    Topics: Action Potentials; Aging; Animals; Antioxidants; Cerebellum; Dietary Supplements; gamma-Aminobutyric

1999
Anticonvulsant taurine derivatives modify taurine and GABA release in the mouse hippocampus.
    Proceedings of the Western Pharmacology Society, 1999, Volume: 42

    Topics: Aging; Animals; Anticonvulsants; Brain Ischemia; Female; gamma-Aminobutyric Acid; Hippocampus; In Vi

1999
Distribution and developmental changes in GABA-like immunoreactive neurons in the central nervous system of pond snail, Lymnaea stagnalis.
    The Journal of comparative neurology, 2000, Mar-13, Volume: 418, Issue:3

    Topics: Aging; Animals; Brain; Central Nervous System; gamma-Aminobutyric Acid; Ganglia, Invertebrate; Lymna

2000
Chronic NMDA exposure accelerates development of GABAergic inhibition in the superior colliculus.
    Journal of neurophysiology, 2000, Volume: 83, Issue:3

    Topics: Aging; Animals; Carrier Proteins; Coloring Agents; Electrophysiology; Female; GABA Plasma Membrane T

2000
Effect of adenosine A2A receptor stimulation on GABA release from the striatum of young and aged rats in vivo.
    Neuroreport, 1999, Dec-16, Volume: 10, Issue:18

    Topics: Adenosine; Aging; Animals; Animals, Newborn; Corpus Striatum; gamma-Aminobutyric Acid; Male; Microdi

1999
Inhibitory threshold for critical-period activation in primary visual cortex.
    Nature, 2000, Mar-09, Volume: 404, Issue:6774

    Topics: Aging; Animals; Critical Period, Psychological; Diazepam; gamma-Aminobutyric Acid; Haplorhini; Mice;

2000
Dietary protein alters age-induced change in hypothalamic GABA and immune response.
    Neuroscience, 2000, Volume: 97, Issue:2

    Topics: Aging; Animals; Cytotoxicity, Immunologic; Dietary Proteins; gamma-Aminobutyric Acid; Hypothalamus;

2000
Colocalization of choline acetyltransferase and gamma-aminobutyric acid in the developing and adult turtle retinas.
    The Journal of comparative neurology, 2000, May-15, Volume: 420, Issue:4

    Topics: Aging; Animals; Choline O-Acetyltransferase; Fluorescent Antibody Technique; gamma-Aminobutyric Acid

2000
Characterisation of GABA(A) receptors in fetal, neonatal and adult ovine brain: region and age related changes and the effects of allopregnanolone.
    Neuropharmacology, 2000, Jul-10, Volume: 39, Issue:9

    Topics: Aging; Animals; Animals, Newborn; Binding, Competitive; Brain; Brain Stem; Bridged Bicyclo Compounds

2000
Age-related resistance to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid-induced hippocampal lesion.
    Hippocampus, 2000, Volume: 10, Issue:3

    Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biological Transport; Biom

2000
[Changes of GABA immunoreactivity in aged rat cochlear nucleus].
    Zhonghua yi xue za zhi, 1998, Volume: 78, Issue:1

    Topics: Aging; Animals; Cochlear Nucleus; Female; gamma-Aminobutyric Acid; Immunohistochemistry; Male; Presb

1998
Age-related differences in the effects of bacterial endotoxin (LPS) upon the release of LHRH, gonadotropins and hypothalamic inhibitory amino acid neurotransmitters measured in tissues explanted from intact male rats.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2000, Volume: 108, Issue:3

    Topics: Aging; Animals; Follicle Stimulating Hormone; gamma-Aminobutyric Acid; Gonadotropin-Releasing Hormon

2000
Benzodiazepine modulation of GABAergic responses is intact in the cerebellum of aged F344 rats.
    Neuroscience letters, 2000, Sep-22, Volume: 291, Issue:3

    Topics: Action Potentials; Aging; Animals; Anti-Anxiety Agents; Cerebellum; Dose-Response Relationship, Drug

2000
Developmental regulation of glutamic acid decarboxylase mRNA expression and splicing in the rat striatum by dopamine.
    Brain research. Molecular brain research, 2000, Sep-30, Volume: 81, Issue:1-2

    Topics: Aging; Animals; Animals, Newborn; Cells, Cultured; Corpus Striatum; Dopamine; Embryonic and Fetal De

2000
Do subplate neurons comprise a transient population of cells in developing neocortex of rats?
    The Journal of comparative neurology, 2000, Oct-30, Volume: 426, Issue:4

    Topics: Acetylcholinesterase; Aging; Animals; Animals, Newborn; Atrophy; Biomarkers; Bromodeoxyuridine; Cell

2000
[The neuroethological basis of learning and memory decline in aged rats].
    Sheng li ke xue jin zhan [Progress in physiology], 1997, Volume: 28, Issue:4

    Topics: Aging; Animals; Dentate Gyrus; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Hippocampus

1997
Potassium-coupled chloride cotransport controls intracellular chloride in rat neocortical pyramidal neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Nov-01, Volume: 20, Issue:21

    Topics: Aging; Animals; Carrier Proteins; Chlorides; Diuretics; Dose-Response Relationship, Drug; Evoked Pot

2000
GABA binding to cerebral cortical GABAA and GABAB sites in aging mice.
    Proceedings of the Western Pharmacology Society, 2000, Volume: 43

    Topics: Aging; Animals; Cerebral Cortex; Cognition; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Ki

2000
Hypothermia inhibits ischemia-induced efflux of amino acids and neuronal damage in the hippocampus of aged rats.
    Brain research, 2000, Nov-24, Volume: 884, Issue:1--2

    Topics: Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Cerebrovascular Circulation; Ex

2000
Heterogeneity in the basic membrane properties of postnatal gonadotropin-releasing hormone neurons in the mouse.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Feb-01, Volume: 21, Issue:3

    Topics: Action Potentials; Aging; Animals; Barium; Calcium Channels; Calcium Signaling; Cell Membrane; Cesiu

2001
Neurotransmitter contents in the retina of RCS rat.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2000, Volume: 238, Issue:12

    Topics: Acetylcholine; Aging; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Dopamine; gamma-

2000
Parvalbumin and GABA in the developing somatosensory thalamus of the rat: an immunocytochemical ultrastructural correlation.
    Anatomy and embryology, 2001, Volume: 203, Issue:2

    Topics: Aging; Animals; gamma-Aminobutyric Acid; Immunohistochemistry; Microscopy, Electron; Parvalbumins; R

2001
Responses of young and aged rat inferior colliculus neurons to sinusoidally amplitude modulated stimuli.
    Hearing research, 2001, Volume: 153, Issue:1-2

    Topics: Acoustic Stimulation; Aging; Animals; Evoked Potentials, Auditory; gamma-Aminobutyric Acid; Humans;

2001
Chemical network of the living human brain. Evidence of reorganization with aging.
    Brain research. Cognitive brain research, 2001, Volume: 11, Issue:2

    Topics: Adult; Aging; Brain; Brain Chemistry; Female; gamma-Aminobutyric Acid; Glucose; Humans; Magnetic Res

2001
Increase in the number of detectable preoptic glutamic acid decarboxylase 67-immunoreactive cells in immature male rats.
    Neuroscience research, 2001, Volume: 40, Issue:2

    Topics: Aging; Animals; Cell Count; Cell Size; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Gonadotropi

2001
Postnatal alterations of GABA receptor profiles in the rat superior colliculus.
    Neuroscience, 2001, Volume: 104, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Cell Count; Cell Differentiation; gamma-Aminobutyric Acid; Immunoh

2001
Slow IPSC kinetics, low levels of alpha1 subunit expression and paired-pulse depression are distinct properties of neonatal inhibitory GABAergic synaptic connections in the mouse superior colliculus.
    The European journal of neuroscience, 2001, Volume: 13, Issue:11

    Topics: Action Potentials; Aging; Animals; Animals, Newborn; Bicuculline; Cell Differentiation; Electric Sti

2001
A critical role of the strychnine-sensitive glycinergic system in spontaneous retinal waves of the developing rabbit.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Jul-15, Volume: 21, Issue:14

    Topics: Aging; Animals; Calcium; Carrier Proteins; Fluorescent Dyes; GABA Antagonists; gamma-Aminobutyric Ac

2001
GABAergic neuronal subtypes in the human frontal cortex--development and deficits in schizophrenia.
    Journal of chemical neuroanatomy, 2001, Volume: 22, Issue:1-2

    Topics: Aged; Aging; Calbindin 2; Calbindins; Female; Frontal Lobe; gamma-Aminobutyric Acid; Humans; Immunoh

2001
Development of GABA-immunoreactive neuron patterning in the spinal cord.
    The Journal of comparative neurology, 2001, Sep-10, Volume: 438, Issue:1

    Topics: Aging; Animals; Body Patterning; Cell Size; Dopamine; gamma-Aminobutyric Acid; Immunohistochemistry;

2001
Diazepam fails to potentiate GABA-induced chloride uptake and to produce anxiolytic-like action in aged rats.
    Pharmacology, biochemistry, and behavior, 2001, Volume: 68, Issue:4

    Topics: Aging; Animals; Anti-Anxiety Agents; Cerebral Cortex; Chlorides; Diazepam; Dose-Response Relationshi

2001
Expression of estrogen receptor (ER)-alpha and -beta immunoreactivity in hippocampal cell cultures with special attention to GABAergic neurons.
    Journal of neuroscience research, 2001, Sep-01, Volume: 65, Issue:5

    Topics: Aging; Animals; Animals, Newborn; Astrocytes; Cell Size; Cells, Cultured; Estrogen Receptor alpha; E

2001
Region-specific developmental specialization of GABA-glycine cosynapses in laminas I-II of the rat spinal dorsal horn.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Oct-15, Volume: 21, Issue:20

    Topics: Action Potentials; Aging; Animals; Calcium Channel Blockers; Calcium Channels; GABA Modulators; gamm

2001
GABAergic neurons that pioneer hippocampal area CA1 of the mouse: morphologic features and multiple fates.
    The Journal of comparative neurology, 2001, Oct-15, Volume: 439, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Apoptosis; Bromodeoxyuridine; Cell Compartmentation; Cell Differen

2001
The nonuniform distribution of the GABA(A) receptor alpha 1 subunit influences inhibitory synaptic transmission to motoneurons within a motor nucleus.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Nov-01, Volume: 21, Issue:21

    Topics: Aging; Animals; Animals, Newborn; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Glycin

2001
The development of inhibitory synaptic specializations in the mouse deep cerebellar nuclei.
    Neuroscience, 2001, Volume: 105, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Calbindins; Cell Differentiation; Cerebellar Cortex; Cerebellar Nu

2001
In vivo NO/cGMP signalling in the hippocampus.
    Neurochemical research, 2001, Volume: 26, Issue:8-9

    Topics: Aging; Animals; Cyclic GMP; Epilepsy; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Nitric Ox

2001
Differential expression of GAD(65) and GAD(67) during the development of the rat retina.
    Brain research, 2001, Nov-23, Volume: 919, Issue:2

    Topics: Aging; Amacrine Cells; Animals; Cell Differentiation; Exons; gamma-Aminobutyric Acid; Gene Expressio

2001
Postnatal maturation of GABA(A) and GABA(C) receptor function in the mammalian superior colliculus.
    The European journal of neuroscience, 2001, Volume: 14, Issue:8

    Topics: Aging; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Excitatory Postsynaptic Potentia

2001
Sexual dimorphism and developmental regulation of substantia nigra function.
    Annals of neurology, 2001, Volume: 50, Issue:5

    Topics: Aging; Animals; Animals, Newborn; Castration; Convulsants; Disease Susceptibility; Female; GABA Agon

2001
Tonic activity and GABA responsiveness of medial vestibular nucleus neurons in aged rats.
    Neuroreport, 2001, Dec-21, Volume: 12, Issue:18

    Topics: Aging; Animals; Baclofen; Dose-Response Relationship, Drug; GABA Agonists; gamma-Aminobutyric Acid;

2001
Developmental sex differences in glutamic acid decarboxylase (GAD(65)) and the housekeeping gene, GAPDH.
    Brain research, 2001, Dec-20, Volume: 922, Issue:2

    Topics: Aging; Amygdala; Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus; Blotting, Western; Dors

2001
Long-term depression in the basolateral amygdala of the mouse involves the activation of interneurons.
    Neuroscience, 2001, Volume: 107, Issue:1

    Topics: Aging; Amygdala; Animals; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cal

2001
Early development of the retina and pineal complex in the sea lamprey: comparative immunocytochemical study.
    The Journal of comparative neurology, 2002, Jan-14, Volume: 442, Issue:3

    Topics: Aging; Animals; Cell Differentiation; Female; gamma-Aminobutyric Acid; Immunohistochemistry; Lamprey

2002
Cholecystokinin-immunopositive basket and Schaffer collateral-associated interneurones target different domains of pyramidal cells in the CA1 area of the rat hippocampus.
    Neuroscience, 2002, Volume: 109, Issue:1

    Topics: Action Potentials; Aging; Animals; Animals, Newborn; Axons; Calbindins; Cholecystokinin; gamma-Amino

2002
Single-cell RT-PCR detects shifts in mRNA expression profiles of basal forebrain neurons during aging.
    Brain research. Molecular brain research, 2002, Jan-31, Volume: 98, Issue:1-2

    Topics: Aging; Animals; Calbindin 1; Calbindin 2; Calbindins; Calcium; Choline O-Acetyltransferase; Choliner

2002
Ontogenic modifications in the effect of the GABAergic system on the hypothalamic excitatory amino acids: its relationship with GABAergic control of gonadotrophin secretion during sexual maturation in female rats.
    Brain research. Developmental brain research, 2002, Jan-31, Volume: 133, Issue:1

    Topics: Aging; Aminooxyacetic Acid; Animals; Aspartic Acid; Excitatory Amino Acids; Female; Follicle Stimula

2002
Plasticity of GABA(a) system during ageing: focus on vestibular compensation and possible pharmacological intervention.
    Brain research, 2002, Mar-01, Volume: 929, Issue:1

    Topics: Adaptation, Physiological; Aging; Animals; Brain; Flunitrazepam; GABA Modulators; gamma-Aminobutyric

2002
Activity- and age-dependent GABAergic synaptic plasticity in the developing rat hippocampus.
    The European journal of neuroscience, 2001, Volume: 14, Issue:12

    Topics: Action Potentials; Aging; Animals; Animals, Newborn; Electric Stimulation; Excitatory Amino Acid Ant

2001
Baclofen inhibits ANP-mediated cyclic GMP synthesis in the rat cervical spinal cord.
    Neuroscience letters, 2002, Mar-15, Volume: 321, Issue:1-2

    Topics: Aging; Animals; Atrial Natriuretic Factor; Baclofen; Cervical Vertebrae; Cyclic GMP; GABA Agonists;

2002
Estrogen regulates the development of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Apr-01, Volume: 22, Issue:7

    Topics: Aging; Animals; Animals, Newborn; Blotting, Western; Brain-Derived Neurotrophic Factor; Cells, Cultu

2002
Differential susceptibility to ageing of rat preganglionic neurones projecting to the major pelvic ganglion and of their afferent inputs.
    Autonomic neuroscience : basic & clinical, 2002, Feb-28, Volume: 96, Issue:1

    Topics: Afferent Pathways; Aging; Animals; Dendrites; Disease Susceptibility; Efferent Pathways; gamma-Amino

2002
Ontogeny of gamma-aminobutyric acid-immunoreactive neuronal populations in the forebrain and midbrain of the sea lamprey.
    The Journal of comparative neurology, 2002, May-13, Volume: 446, Issue:4

    Topics: Aging; Animals; Body Patterning; Calbindin 2; Cell Differentiation; Embryo, Nonmammalian; Female; ga

2002
Differential ontogeny of GABA(B)-receptor-mediated pre- and postsynaptic modulation of GABA and glycine transmission in respiratory rhythm-generating network in mouse.
    The Journal of physiology, 2002, Apr-15, Volume: 540, Issue:Pt 2

    Topics: Aging; Animals; Animals, Newborn; Brain Stem; Electrophysiology; Excitatory Postsynaptic Potentials;

2002
Age-dependent changes in 24-hour rhythms of thymic and circulating growth hormone and adrenocorticotropin in rats injected with Freund's adjuvant.
    Neuroimmunomodulation, 2001, Volume: 9, Issue:5

    Topics: Adrenocorticotropic Hormone; Aging; Animals; Aspartic Acid; Behavior, Animal; Chronobiology Disorder

2001
Distribution of postsynaptic GABA(A) receptor aggregates in the deep cerebellar nuclei of normal and mutant mice.
    The Journal of comparative neurology, 2002, Jun-03, Volume: 447, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Carrier Proteins; Cell Differentiation; Cerebellar Nuclei; Dendrit

2002
Postnatal development of parvalbumin- and GABA transporter-immunoreactive axon terminals in monkey prefrontal cortex.
    The Journal of comparative neurology, 2002, Jun-24, Volume: 448, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Carrier Proteins; Cell Differentiation; Female; GABA Plasma Membra

2002
Alterations of amino acids and monoamine metabolism in male Fmr1 knockout mice: a putative animal model of the human fragile X mental retardation syndrome.
    Neural plasticity, 2001, Volume: 8, Issue:4

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Brain St

2001
Possible role of glutamate, aspartate, glutamine, GABA or taurine on cadmium toxicity on the hypothalamic pituitary axis activity in adult male rats.
    Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2002, Volume: 15, Issue:2

    Topics: Administration, Oral; Aging; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Cadmium; gamma-Am

2002
Expression and dendritic mRNA localization of GABAC receptor rho1 and rho2 subunits in developing rat brain and spinal cord.
    The European journal of neuroscience, 2002, Volume: 15, Issue:11

    Topics: Aging; Animals; Animals, Newborn; Brain; Dendrites; GABA Antagonists; gamma-Aminobutyric Acid; Gene

2002
Effect of aging on neurotransmitter receptor binding in rat and human brain.
    Life sciences, 1979, Jan-22, Volume: 24, Issue:4

    Topics: Adult; Aged; Aging; Alprenolol; Animals; Brain; Cerebellum; Cyclic AMP; gamma-Aminobutyric Acid; Hum

1979
Postnatal amino acid uptake by the rat small intestine. Changes in membrane transport systems for amino acids associated with maturation of jejunal morphology.
    Journal of developmental physiology, 1979, Volume: 1, Issue:2

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Arginine; Biological Transport, Active; gamma-Aminobu

1979
Differential effects of agonal status on measurements of GABA and glutamate decarboxylase in human post-mortem brain tissue from control and Huntington's chorea subjects.
    Journal of neurochemistry, 1979, Volume: 33, Issue:3

    Topics: Adolescent; Adult; Aged; Aging; Animals; Brain; Carboxy-Lyases; gamma-Aminobutyric Acid; Glutamate D

1979
Dihydropicrotoxinin binding sites in rat brain: comparison to GABA receptors.
    Brain research, 1978, Jul-21, Volume: 150, Issue:3

    Topics: Aging; Aminobutyrates; Animals; Binding Sites; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Corpu

1978
Similarities between cysteinesulphinate transaminase and aspartate aminotransferase.
    Ciba Foundation symposium, 1979, Issue:72

    Topics: Aging; Animals; Aspartate Aminotransferases; Brain; Electrophoresis, Polyacrylamide Gel; gamma-Amino

1979
GABA fluxes in presynaptic nerve endings from immature rats.
    Journal of neurochemistry, 1979, Volume: 33, Issue:5

    Topics: Aging; Animals; Biological Transport; Brain; Calcium; gamma-Aminobutyric Acid; Intracellular Membran

1979
GABA metabolism in cultured glial cells.
    Advances in experimental medicine and biology, 1979, Volume: 123

    Topics: 4-Aminobutyrate Transaminase; Aging; Animals; Brain; Cell Line; Cells, Cultured; Cycloheximide; gamm

1979
Rapid method for the assay of 4-aminobutyric acid (GABA), glutamic acid and aspartic acid in brain tissue and subcellular fractions.
    Journal of chromatography, 1979, Apr-11, Volume: 162, Issue:4

    Topics: Aging; Animals; Aspartic Acid; Brain; Brain Chemistry; Chromatography, Ion Exchange; Chromatography,

1979
Histochemical detection of gamma aminobutyric acid (GABA) degradative enzymes in the Purkinje cell population of old rat cerebellum.
    Basic and applied histochemistry, 1979, Volume: 23, Issue:4

    Topics: 4-Aminobutyrate Transaminase; Aging; Aldehyde Oxidoreductases; Animals; Formazans; gamma-Aminobutyri

1979
Developmental changes and dietary histidine manipulation: effect on rat olfactory bulb and leg muscle components.
    The Journal of nutrition, 1978, Volume: 108, Issue:8

    Topics: Aging; Aminobutyrates; Animals; Anserine; Carnosine; Diet; Dipeptides; Female; gamma-Aminobutyric Ac

1978
Biochemical aspects of the aging brain.
    Age and ageing, 1978, Volume: Suppl

    Topics: Acetylcholine; Aging; Alzheimer Disease; Brain; Cell Count; Dementia; Energy Metabolism; gamma-Amino

1978
[Possibility of using enriched glial and neuronal cell fractions to study transport of neurotransmitter amino acids in old age].
    Voprosy biokhimii mozga, 1978, Volume: 13

    Topics: Aging; Animals; Brain; gamma-Aminobutyric Acid; Neuroglia; Neurons; Rats

1978
The cerebellar glomerulus: isolation and metabolic properties of a purified fraction.
    Journal of neurochemistry, 1976, Volume: 27, Issue:1

    Topics: Aging; Animals; Biological Transport, Active; Cell Fractionation; Cerebellum; gamma-Aminobutyric Aci

1976
Enhanced stimulus--secretion coupling from brains of aged mice.
    Experimental neurology, 1977, Volume: 57, Issue:3

    Topics: Acetylcholine; Aging; Aminobutyrates; Animals; Brain; Calcium; Dopamine; gamma-Aminobutyric Acid; In

1977
Postnatal alterations in effects of potassium on uptake and release of glutamate and GABA in rat brain cortex slices.
    Journal of neurochemistry, 1976, Volume: 26, Issue:5

    Topics: Aging; Aminobutyrates; Animals; Animals, Newborn; Biological Transport; Biological Transport, Active

1976
Changes in the effect of gamma-aminobutyric acid on prolactin secretion during sexual maturation in female rats.
    Endocrinology, 1992, Volume: 131, Issue:1

    Topics: 4-Aminobutyrate Transaminase; Aging; Aminooxyacetic Acid; Animals; Baclofen; Female; gamma-Aminobuty

1992
Age-dependent changes in substantia nigra GABA-mediated seizure suppression.
    Epilepsy research. Supplement, 1992, Volume: 8

    Topics: Aging; Animals; Animals, Newborn; Baclofen; Bicuculline; Dominance, Cerebral; Energy Metabolism; Flu

1992
Changes in ligand binding to GABAA receptor sites in pacific salmon (Oncorhynchus) brain during spawning migration and "aging".
    Journal fur Hirnforschung, 1992, Volume: 33, Issue:4-5

    Topics: Aging; Aminobutyrates; Analgesics; Animals; Baclofen; Bicuculline; Binding, Competitive; Brain; Fema

1992
Development of the glutamate system in rabbit retina.
    Neurochemical research, 1992, Volume: 17, Issue:1

    Topics: Aging; Animals; Animals, Newborn; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Immunohistoche

1992
Mitochondrial enzymes related to glutamate and GABA metabolism in the hippocampus of young and aged rats: a quantitative histochemical study.
    Neurochemical research, 1992, Volume: 17, Issue:2

    Topics: 4-Aminobutyrate Transaminase; Aging; Animals; Electron Transport Complex IV; gamma-Aminobutyric Acid

1992
Modulation of tyrosine hydroxylase gene expression in the rat adrenal gland by exercise: effects of age.
    Brain research. Molecular brain research, 1992, Volume: 14, Issue:1-2

    Topics: Acetylcholine; Adrenal Medulla; Aging; Animals; Catecholamines; Choline O-Acetyltransferase; Enzyme

1992
The ontogeny of the uptake systems for glutamate, GABA, and glycine in synaptic vesicles isolated from rat brain.
    Neurochemical research, 1992, Volume: 17, Issue:5

    Topics: Adenosine Triphosphate; Aging; Animals; Brain; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; G

1992
Age-dependent regulation of GABAA receptors in neocortex.
    Brain research. Molecular brain research, 1992, Volume: 14, Issue:3

    Topics: Aging; Animals; Baclofen; Cats; Cerebral Cortex; GABA-A Receptor Antagonists; gamma-Aminobutyric Aci

1992
Effects of ethanol on Na(+)-dependent amino acid uptake: dependence on rat age and Na+, K(+)-ATPase activity.
    Brain research, 1992, Oct-09, Volume: 593, Issue:1

    Topics: Aging; Alcohols; Animals; Biological Transport; Cerebral Cortex; Dose-Response Relationship, Drug; E

1992
Messenger RNAs coding for receptors and channels in the cerebral cortex of adult and aged rats.
    Brain research. Molecular brain research, 1992, Volume: 13, Issue:1-2

    Topics: Acetylcholine; Aging; Animals; Cerebral Cortex; Female; gamma-Aminobutyric Acid; Glutamates; Glutami

1992
Vasoactive intestinal polypeptide modulates GABAA receptor function in bipolar cells and ganglion cells of the rat retina.
    Journal of neurophysiology, 1992, Volume: 67, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Chloride Channels; Drug Synergism; Electric Conductivity; gamma-Am

1992
Developmental neuron-glia interactions: role of serotonin innervation upon the differentiation of the ependymocytes of the rat subcommissural organ.
    Progress in brain research, 1992, Volume: 91

    Topics: Aging; Animals; Animals, Newborn; Cell Communication; Cell Differentiation; Ependyma; gamma-Aminobut

1992
Temporal and spatial differences of the GABAergic abnormalities during development of the E1 mouse.
    The Japanese journal of psychiatry and neurology, 1992, Volume: 46, Issue:2

    Topics: Aging; Animals; Epilepsy; gamma-Aminobutyric Acid; Hippocampus; Mice; Mice, Neurologic Mutants; Pari

1992
Characterization of the transcallosal response in aged rats and its susceptibility to nootropic drugs.
    Neuropharmacology, 1992, Volume: 31, Issue:10

    Topics: Aging; Animals; Blood Pressure; Cerebral Cortex; Corpus Callosum; Electric Stimulation; Electroencep

1992
Perinatal hypoxic ischemic encephalopathy affects the proportion of GABA-immunoreactive neurons in the cerebral cortex of the rat.
    Brain research, 1992, Oct-02, Volume: 592, Issue:1-2

    Topics: Aging; Animals; Animals, Newborn; Brain Ischemia; Cell Count; Cell Survival; Cerebral Cortex; Epilep

1992
[Use of gamma-aminobutyric acid from various sources in the synthesis of homocarnosine in the brain of animals of various ages].
    Biokhimiia (Moscow, Russia), 1992, Volume: 57, Issue:9

    Topics: Aging; Animals; Brain; Carbon Radioisotopes; Carnosine; gamma-Aminobutyric Acid; Putrescine; Rats

1992
Development of GABA-immunoreactivity in the neocortex of the mouse.
    The Journal of comparative neurology, 1992, Dec-22, Volume: 326, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Cerebral Cortex; Embryonic and Fetal Development; gamma-Aminobutyr

1992
Development of subpopulations of GABAergic neurons in cat visual cortical areas.
    Neuroreport, 1992, Volume: 3, Issue:12

    Topics: Aging; Animals; Cats; Fluorescent Antibody Technique; gamma-Aminobutyric Acid; Immunohistochemistry;

1992
Age dependency of the susceptibility of rats to aminooxyacetic acid seizures.
    Brain research. Developmental brain research, 1992, Jun-19, Volume: 67, Issue:2

    Topics: Aging; Aminooxyacetic Acid; Animals; Anticonvulsants; Body Temperature; Brain; Carbamazepine; Clonaz

1992
Alterations in the properties of hippocampal pyramidal neurons in the aged rat.
    Neuroscience, 1992, Volume: 48, Issue:4

    Topics: Acetylcholine; Action Potentials; Aging; Analysis of Variance; Animals; Baclofen; Carbachol; Electri

1992
Zinc and GABA in developing brain.
    Nature, 1991, Sep-19, Volume: 353, Issue:6341

    Topics: Aging; Animals; Brain; gamma-Aminobutyric Acid; Humans; Rats; Receptors, GABA-A; Zinc

1991
GABA-sensitivity of dorsal column axons: an in vitro comparison between adult and neonatal rat spinal cords.
    Brain research. Developmental brain research, 1991, Jul-16, Volume: 61, Issue:1

    Topics: Action Potentials; Aging; Animals; Animals, Newborn; Axons; gamma-Aminobutyric Acid; Isonicotinic Ac

1991
Quantitative autoradiographic study of the postnatal development of benzodiazepine binding sites and their coupling to GABA receptors in the rat brain.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1991, Volume: 9, Issue:4

    Topics: Aging; Animals; Autoradiography; Brain; Flunitrazepam; gamma-Aminobutyric Acid; Organ Specificity; R

1991
Adult-like biphasic neurobehavioral changes induced by a GABA-A agonist in infant and weanling mice.
    Brain research. Developmental brain research, 1991, Aug-19, Volume: 61, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Ataxia; Behavior, Animal; Catalepsy; Dose-Response Relationship, D

1991
Aging reduces the mRNA of alpha 1 GABAA receptor subunit in rat cerebral cortex.
    European journal of pharmacology, 1991, Oct-14, Volume: 208, Issue:2

    Topics: Aging; Animals; Blotting, Northern; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocycl

1991
Postnatal maturation of the GABAergic system in rat neocortex.
    Journal of neurophysiology, 1991, Volume: 65, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Aging; Animals; Animals, Newborn; Baclofen; Bicucull

1991
The ontogeny of the uptake systems for glycine, GABA and glutamate in synaptic vesicles isolated from rat spinal cord-medulla.
    Brain research. Developmental brain research, 1991, Dec-17, Volume: 64, Issue:1-2

    Topics: Aging; Animals; Animals, Newborn; Cell Membrane; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid;

1991
N-methyl-D-aspartate and aspartate raise the cytosolic free calcium concentration by acting upon receptors transiently expressed on immature cerebellar Purkinje cells.
    Neuroscience letters, 1991, Oct-28, Volume: 132, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Animals, Newborn;

1991
Biogenic amines and GABA in the larval and adult forms of the nematode Nippostrongylus brasiliensis.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1991, Volume: 100, Issue:3

    Topics: Aging; Animals; Biogenic Amines; Feces; gamma-Aminobutyric Acid; Larva; Nippostrongylus; Rats; Rats,

1991
GABA inhibits the rise in cytosolic free calcium concentration in depolarized immature cerebellar Purkinje cells.
    Neuroscience letters, 1991, Jan-28, Volume: 122, Issue:2

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1991
Activity-dependent regulation of glutamic acid decarboxylase in the rat barrel cortex: effects of neonatal versus adult sensory deprivation.
    The Journal of comparative neurology, 1991, May-08, Volume: 307, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamate Decarboxylase;

1991
Characterization of microcarrier cultures of neurons and astrocytes from cerebral cortex and cerebellum.
    Neurochemical research, 1991, Volume: 16, Issue:8

    Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Cerebellum; Cerebral Cortex; Culture Te

1991
Effects of ageing on the content in sulfur-containing amino acids in rat brain.
    Journal of neural transmission. General section, 1991, Volume: 86, Issue:3

    Topics: Aging; Amino Acids, Sulfur; Animals; Brain Chemistry; gamma-Aminobutyric Acid; Male; Rats; Rats, Inb

1991
Postnatal expression of glutamate decarboxylases in developing rat cerebellum.
    Neurochemical research, 1991, Volume: 16, Issue:3

    Topics: Aging; Animals; Blotting, Northern; Blotting, Western; Cerebellar Cortex; Cerebellum; gamma-Aminobut

1991
Changes in GABA-immunoreactivity and GABA-transaminase activity in rat amygdaloid complex in aging.
    Journal fur Hirnforschung, 1991, Volume: 32, Issue:2

    Topics: 4-Aminobutyrate Transaminase; Aging; Amygdala; Animals; Astrocytes; gamma-Aminobutyric Acid; Glial F

1991
Modification of gamma-aminobutyric acidA receptor binding and function by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline in vitro and in vivo: effects of aging.
    Journal of neurochemistry, 1991, Volume: 56, Issue:4

    Topics: Aging; Animals; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic;

1991
Pharmacologic characterization of GABAA/benzodiazepine receptor in rat hippocampus during aging.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:3

    Topics: Aging; Animals; Binding Sites; Cerebellum; Cerebral Cortex; Culture Techniques; Drug Interactions; F

1991
Postnatal development of ganglion cells in the rabbit retina: characterizations with AB5 and GABA antibodies.
    Brain research. Developmental brain research, 1991, Jul-16, Volume: 61, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Antibodies, Monoclonal; gamma-Aminobutyric Acid; Immunohistochemis

1991
Immunocytochemical and neurochemical evidence for age-related loss of GABA in the inferior colliculus: implications for neural presbycusis.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1990, Volume: 10, Issue:7

    Topics: Acetylcholine; Aging; Animals; Aspartic Acid; Calcium; gamma-Aminobutyric Acid; Glutamates; Glutamic

1990
Loss of gamma-aminobutyric acid (GABA) immunoreactivity from mouse first somatosensory (SI) cortex following neonatal, but not adult, denervation.
    Brain research, 1991, Jan-04, Volume: 538, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Denervation; gamma-Aminobutyric Acid; Immunohistochemistry; Mice;

1991
Ontogeny of glutamate decarboxylase and gamma-aminobutyric acid immunoreactivities in the rat cochlea.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 1990, Volume: 248, Issue:1

    Topics: Aging; Animals; Cochlea; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Immunoenzyme Techniques;

1990
GABA content and synthesis in the aging rat brain.
    Experimental gerontology, 1990, Volume: 25, Issue:6

    Topics: Aging; Aminooxyacetic Acid; Animals; Brain; Cerebral Cortex; Corpus Striatum; gamma-Aminobutyric Aci

1990
Effects of cholinergic drugs and cerebral metabolic activators on memory impairment in old rats.
    Journal of pharmacobio-dynamics, 1990, Volume: 13, Issue:12

    Topics: Acetylcholine; Aging; Animals; Benzoquinones; Brain; Central Nervous System Agents; gamma-Aminobutyr

1990
Role of hypothalamic factors (growth-hormone-releasing hormone and gamma-aminobutyric acid) in the regulation of growth hormone secretion in the neonatal and adult rat.
    Neuroendocrinology, 1990, Volume: 52, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Female; gamma-Aminobutyric Acid; Growth Hormone; Growth Hormone-Re

1990
[3H]nipecotic acid binding to gamma-aminobutyric acid uptake sites in postmortem human brain.
    Journal of neurochemistry, 1990, Volume: 55, Issue:1

    Topics: Aged; Aging; Binding Sites; Brain; Cadaver; Female; gamma-Aminobutyric Acid; Hippocampus; Humans; Hu

1990
Regulation of the cytosolic free calcium concentration by Na+ spikes in immature cerebellar neurons with N-methyl-D-aspartate receptors.
    Brain research, 1990, Sep-10, Volume: 527, Issue:1

    Topics: Action Potentials; Aging; Animals; Calcium; Cerebellum; Cytosol; Gallopamil; gamma-Aminobutyric Acid

1990
The allosteric glycine site of the N-methyl-D-aspartate receptor modulates GABAergic-mediated synaptic events in neonatal rat CA3 hippocampal neurons.
    Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:1

    Topics: Aging; Allosteric Regulation; Allosteric Site; Animals; Animals, Newborn; Aspartic Acid; Electric Co

1990
GABAergic mechanisms in the CA3 hippocampal region during early postnatal life.
    Progress in brain research, 1990, Volume: 83

    Topics: Action Potentials; Aging; Animals; Bicuculline; gamma-Aminobutyric Acid; Hippocampus; Immunohistoche

1990
Hyperthermia-induced seizures with a servo system: neurophysiological roles of age, temperature elevation rate and regional GABA content in the rat.
    Brain & development, 1990, Volume: 12, Issue:3

    Topics: Aging; Animals; Body Temperature; Brain Chemistry; Female; gamma-Aminobutyric Acid; Hyperthermia, In

1990
Determination of gamma-aminobutyric acid in human cerebrospinal fluid by isocratic high-performance liquid chromatography.
    Journal of chromatography, 1990, Aug-03, Volume: 529, Issue:2

    Topics: Adult; Aged; Aging; Amino Acids; Amino Acids, Neutral; Chromatography, High Pressure Liquid; Female;

1990
Immuno- and histochemical data on changed GABA transmission in aged rat cerebellum.
    Journal fur Hirnforschung, 1990, Volume: 31, Issue:4

    Topics: 4-Aminobutyrate Transaminase; Aging; Animals; Cerebellar Cortex; Cerebellum; gamma-Aminobutyric Acid

1990
Factors involved in the age-related alteration in the efficiency of the brain bioenergetics.
    Mechanisms of ageing and development, 1990, Volume: 56, Issue:2

    Topics: Adenine Nucleotides; Aging; Animals; Brain; Electron Transport; Energy Metabolism; gamma-Aminobutyri

1990
Postnatal development of 3H-GABA-accumulating cells in rabbit retina.
    The Journal of comparative neurology, 1986, Jan-01, Volume: 243, Issue:1

    Topics: Age Factors; Aging; Animals; Animals, Newborn; Autoradiography; gamma-Aminobutyric Acid; Microscopy,

1986
Aging reduces the GABA-dependent 36Cl- flux in rat brain membrane vesicles.
    Life sciences, 1988, Volume: 43, Issue:22

    Topics: Aging; Animals; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocycl

1988
Discrimination of heterogenous mRNAs encoding strychnine-sensitive glycine receptors in Xenopus oocytes by antisense oligonucleotides.
    Proceedings of the National Academy of Sciences of the United States of America, 1989, Volume: 86, Issue:20

    Topics: Aging; Animals; Base Sequence; beta-Alanine; Female; gamma-Aminobutyric Acid; Glycine; Kainic Acid;

1989
Postnatal evolution of the gamma-aminobutyric acid/benzodiazepine receptor complex in a model of inherited epilepsy: the quaking mouse.
    Journal of neurochemistry, 1989, Volume: 52, Issue:2

    Topics: Aging; Animals; Brain; Brain Stem; Cerebellum; Diazepam; Diencephalon; Epilepsy; Flunitrazepam; gamm

1989
Changes in the amounts of amino acids associated with nerve endings (synaptosomes) during synaptogenesis.
    Neurochemical research, 1989, Volume: 14, Issue:4

    Topics: Aging; Amino Acids; Animals; Brain; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutamic A

1989
Distribution of GABAergic neurons in late fetal and early postnatal rat hippocampus.
    Brain research. Developmental brain research, 1989, Dec-01, Volume: 50, Issue:2

    Topics: Aging; Animals; Embryonic and Fetal Development; gamma-Aminobutyric Acid; Hippocampus; Immunohistoch

1989
Postnatal development of GABA-mediated synaptic inhibition in rat hippocampus.
    Neuroscience, 1989, Volume: 28, Issue:3

    Topics: Action Potentials; Aging; Animals; Bicuculline; Electric Stimulation; gamma-Aminobutyric Acid; Gluta

1989
Release of taurine and GABA from cerebellar slices from developing and adult mice.
    Neuroscience, 1989, Volume: 29, Issue:2

    Topics: Aging; Animals; Bicuculline; Cerebellum; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Kinet

1989
Developmental changes in the calcium dependency of gamma-aminobutyric acid release from isolated growth cones: correlation with growth cone morphology.
    Journal of neurochemistry, 1989, Volume: 53, Issue:3

    Topics: Aging; Animals; Axons; Calcium; Dendrites; Diencephalon; Female; gamma-Aminobutyric Acid; Kinetics;

1989
Changes with aging in the levels of amino acids in rat CNS structural elements. I. Glutamate and related amino acids.
    Neurochemical research, 1989, Volume: 14, Issue:6

    Topics: Aging; Animals; Aspartic Acid; Brain; Brain Mapping; Brain Stem; Cerebellar Cortex; Cerebral Cortex;

1989
Development of GABA immunoreactivity in brainstem auditory nuclei of the chick: ontogeny of gradients in terminal staining.
    The Journal of comparative neurology, 1989, Jun-22, Volume: 284, Issue:4

    Topics: Aging; Animals; Auditory Pathways; Brain Stem; Cell Differentiation; Chick Embryo; Chickens; gamma-A

1989
GABA-stimulated chloride uptake and enhancement by diazepam in synaptoneurosomes from rat brain during prenatal and postnatal development.
    Brain research. Developmental brain research, 1989, Sep-01, Volume: 49, Issue:1

    Topics: Aging; Animals; Brain; Chlorides; Diazepam; Fetus; gamma-Aminobutyric Acid; Rats; Synaptosomes

1989
Ontogeny of high affinity uptake of GABA studied in 'minislices' (tissue prisms) of rat cerebral cortex.
    Brain research. Developmental brain research, 1989, Oct-01, Volume: 49, Issue:2

    Topics: Aging; Animals; Cerebral Cortex; gamma-Aminobutyric Acid; In Vitro Techniques; Rats; Rats, Inbred St

1989
When does GABA-like immunoreactivity appear in the rat cerebellar GABAergic neurons?
    Brain research, 1989, Nov-20, Volume: 502, Issue:2

    Topics: Aging; Animals; Cerebellum; Embryonic and Fetal Development; gamma-Aminobutyric Acid; Immunohistoche

1989
GABA, benzodiazepine and serotonergic receptor development in the dorsal raphe nucleus: electrophysiological studies.
    Brain research, 1987, Volume: 432, Issue:2

    Topics: Action Potentials; Aging; Animals; Clonazepam; Electric Stimulation; gamma-Aminobutyric Acid; Raphe

1987
Age-related changes in GABA and benzodiazepine receptor binding in rat brain are influenced by sampling time.
    Progress in neuro-psychopharmacology & biological psychiatry, 1988, Volume: 12, Issue:2-3

    Topics: Aging; Animals; Brain; Cerebral Cortex; Circadian Rhythm; Diazepam; gamma-Aminobutyric Acid; Kinetic

1988
Quantitative comparisons of gamma-aminobutyric acid neurons and receptors in the visual cortex of normal and dark-reared cats.
    The Journal of comparative neurology, 1988, Jun-08, Volume: 272, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Cats; Darkness; gamma-Aminobutyric Acid; Neurons; Receptors, GABA-

1988
Cerebellar GABAA and benzodiazepine receptor characteristics in young and aged mice.
    Brain research bulletin, 1988, Volume: 21, Issue:2

    Topics: Aging; Animals; Cerebellum; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred ICR; Muscimol; Recepto

1988
Some long-lasting neurochemical effects of prenatal or early postnatal exposure to diazepam.
    Journal of neurochemistry, 1985, Volume: 45, Issue:1

    Topics: Aging; Animals; Brain; Choline; Diazepam; Female; Frontal Lobe; gamma-Aminobutyric Acid; Hippocampus

1985
Aspartate metabolism in rats during aging.
    Experimental gerontology, 1985, Volume: 20, Issue:3-4

    Topics: Aging; Animals; Aspartic Acid; Brain; Carbon Dioxide; Cerebral Cortex; gamma-Aminobutyric Acid; Glut

1985
[Ageing and neurotransmitters].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1985, Volume: 74, Issue:10

    Topics: Acetylcholine; Aged; Aging; Alzheimer Disease; Animals; Brain; Choline O-Acetyltransferase; Dopamine

1985
Regional distribution of amino acid transmitters in postmortem brains of presenile and senile dementia of Alzheimer type.
    Annals of neurology, 1986, Volume: 19, Issue:3

    Topics: Aged; Aging; Alzheimer Disease; Aspartic Acid; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic

1986
A postmortem study of amino acid neurotransmitters in Alzheimer's disease.
    Annals of neurology, 1986, Volume: 20, Issue:5

    Topics: Aged; Aging; Alanine; Alzheimer Disease; Amino Acids; Aspartic Acid; Brain; gamma-Aminobutyric Acid;

1986
Postnatal development of neurons containing both catecholaminergic and GABAergic traits in the rat main olfactory bulb.
    Brain research, 1987, Feb-17, Volume: 403, Issue:2

    Topics: Aging; Animals; Catecholamines; Cell Count; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Neuron

1987
Release of neurotransmitter amino acids from rat brain synaptosomes and its regulation in aging.
    Gerontology, 1988, Volume: 34, Issue:1-2

    Topics: Aging; Amino Acids; Animals; Aspartic Acid; Brain; Calcium; gamma-Aminobutyric Acid; Glutamates; Glu

1988
The development of GABA-like immunoreactivity in the thoracic ganglia of the locust Schistocerca gregaria.
    Cell and tissue research, 1988, Volume: 254, Issue:3

    Topics: Aging; Animals; gamma-Aminobutyric Acid; Grasshoppers; Immunohistochemistry; Neurotransmitter Agents

1988
Release of endogenous taurine and gamma-aminobutyric acid from brain slices from the adult and developing mouse.
    Journal of neurochemistry, 1989, Volume: 52, Issue:4

    Topics: Aging; Animals; Brain; Calcium; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Magnesium; Mal

1989
[Correlation between the steady state and turnover of gamma-aminobutyric acid during brain maturation in mice].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1986, Volume: 180, Issue:1

    Topics: Aging; Animals; Brain; gamma-Aminobutyric Acid; Kinetics; Mice; Mice, Inbred C57BL; Mice, Inbred DBA

1986
Aging: effect on the interaction of ethanol and pentobarbital with the benzodiazepine-GABA receptor-ionophore complex.
    Brain research, 1985, Sep-23, Volume: 343, Issue:2

    Topics: Aging; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Ethanol; Flunitr

1985
Glutamic acid decarboxylase-like immunoreactive neurites in senile plaques.
    Neuroscience letters, 1985, Aug-30, Volume: 59, Issue:2

    Topics: Aging; Amyloid; Animals; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Immunoen

1985
Calcium-independent release of gamma-aminobutyrate from nerve processes in the developing rabbit retina.
    Neuroscience, 1986, Volume: 17, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Autoradiography; Calcium; Evoked Potentials; gamma-Aminobutyric Ac

1986
GABA receptor binding in rat cerebral cortex and superior cervical ganglion in the absence of GABAergic synapses.
    Neuroscience letters, 1986, May-23, Volume: 66, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Baclofen; Bicuculline; Binding, Competitive; Cerebral Cortex; Fema

1986
Free and conjugated CSF and plasma GABA in Huntington's chorea.
    Acta neurologica Scandinavica, 1986, Volume: 74, Issue:4

    Topics: Adult; Aging; Brain; Female; gamma-Aminobutyric Acid; Humans; Huntington Disease; Male; Middle Aged;

1986
Dissociation of the IPSP and response to GABA during spreading depression-like depolarizations in hippocampal slices.
    Brain research, 1987, Feb-24, Volume: 404, Issue:1-2

    Topics: Aging; Animals; Cortical Spreading Depression; Electrophysiology; gamma-Aminobutyric Acid; Hippocamp

1987
Age-dependent and selective binding of beta-bungarotoxin to GABAergic neurons in the rat cerebellum.
    Neuroscience letters, 1987, Apr-23, Volume: 76, Issue:1

    Topics: Aging; Animals; Bungarotoxins; Cerebellar Cortex; Cerebellum; gamma-Aminobutyric Acid; Immunoenzyme

1987
[Immunoregulative effects of homocarnosine and gamma-aminobuthyric acid].
    Nihon seirigaku zasshi. Journal of the Physiological Society of Japan, 1986, Volume: 48, Issue:6

    Topics: Aging; Animals; Antibody Formation; Carnosine; Dipeptides; gamma-Aminobutyric Acid; Homeostasis; Imm

1986
Ontogeny of GABA-ergic and dopaminergic mediation of gnawing behavior in the mouse.
    Psychopharmacology, 1987, Volume: 92, Issue:1

    Topics: Aging; Animals; Dopamine; Female; gamma-Aminobutyric Acid; Male; Methylphenidate; Mice; Muscimol; St

1987
An investigation into the development of calcium-dependent neurotransmitter release from isolated growth cones.
    Biochemical Society transactions, 1988, Volume: 16, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Brain; Calcium; gamma-Aminobutyric Acid; Neurons; Rats; Synaptic V

1988
Transient GABA-like immunoreactive axons in the corpus callosum of perinatal rats.
    Neuroscience letters, 1988, Oct-31, Volume: 93, Issue:1

    Topics: Aging; Animals; Corpus Callosum; gamma-Aminobutyric Acid; Immunohistochemistry; Neuronal Plasticity;

1988
Changes in the central GABAergic system after acute treatment with corticosterone.
    Naunyn-Schmiedeberg's archives of pharmacology, 1988, Volume: 337, Issue:6

    Topics: Aging; Animals; Brain; Cerebral Cortex; Corpus Striatum; Corticosterone; gamma-Aminobutyric Acid; Hy

1988
Effect of aminooxyacetic acid on the release of preloaded [3H]GABA and radioactive metabolites from slices of developing mouse brain.
    Neurochemical research, 1988, Volume: 13, Issue:10

    Topics: Acetates; Aging; Aminooxyacetic Acid; Animals; Brain; gamma-Aminobutyric Acid; In Vitro Techniques;

1988
Effects of progabide on bicuculline-induced epileptic seizures in developing rats.
    Clinical neuropharmacology, 1988, Volume: 11, Issue:5

    Topics: Aging; Animals; Anticonvulsants; Bicuculline; Female; gamma-Aminobutyric Acid; Male; Rats; Rats, Inb

1988
The development of GABAergic neurons in the rat hippocampal formation. An immunocytochemical study.
    Brain research. Developmental brain research, 1988, Dec-01, Volume: 44, Issue:2

    Topics: Aging; Animals; Cell Count; gamma-Aminobutyric Acid; Hippocampus; Immunohistochemistry; Neurons; Rat

1988
[Comparison of the abilities of GABA accumulation in the discrete brain areas of rats with different ages].
    Sheng li xue bao : [Acta physiologica Sinica], 1988, Volume: 40, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Brain; Female; gamma-Aminobutyric Acid; Male; Rats; Spinal Cord; T

1988
Taurine and GABA release from mouse cerebral cortex slices: potassium stimulation releases more taurine than GABA from developing brain.
    Brain research, 1987, Dec-15, Volume: 465, Issue:1-2

    Topics: Aging; Animals; Brain Chemistry; Cerebral Cortex; gamma-Aminobutyric Acid; Mice; Potassium; Taurine

1987
Postnatal development of transmitter systems: sexual differentiation of the GABAergic system and effects of muscimol.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1986, Volume: 4, Issue:4

    Topics: Aging; Animals; Brain; Female; gamma-Aminobutyric Acid; Male; Maternal-Fetal Exchange; Muscimol; Pre

1986
Synapses between GABA-immunoreactive axonal and dendritic elements in monkey substantia nigra.
    Neuroscience letters, 1986, May-23, Volume: 66, Issue:3

    Topics: Aging; Animals; Axons; Dendrites; gamma-Aminobutyric Acid; Immunoenzyme Techniques; Macaca fascicula

1986
Localization of high-affinity GABA uptake and GABA content in the rat duodenum during development.
    Cell and tissue research, 1987, Volume: 249, Issue:3

    Topics: Aging; Animals; Duodenum; Embryonic and Fetal Development; Epithelium; gamma-Aminobutyric Acid; Hist

1987
Release of gamma-aminobutyric acid from the visual cortex of young kittens.
    Brain research, 1986, Volume: 389, Issue:1-2

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Cats; Chromatography, High Pressure Liquid; Electric

1986
Identification and characterization of pipecolic acid binding sites in mouse brain.
    Neurochemical research, 1985, Volume: 10, Issue:5

    Topics: Aging; Animals; Binding Sites; Brain; Cell Membrane; Cerebral Cortex; gamma-Aminobutyric Acid; Male;

1985
Some properties of guinea pig brain glutamate decarboxylase and its inhibition by the convulsant allylglycine (2-amino-4-pentenoic acid).
    Journal of neurochemistry, 1974, Volume: 23, Issue:2

    Topics: Aging; Allyl Compounds; Amino Acids; Animals; Anions; Brain; Carbon Radioisotopes; Carboxy-Lyases; C

1974
Appearance of gamma aminobutyrate transaminase activity in developing rat brain.
    Journal of neurochemistry, 1974, Volume: 23, Issue:2

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Brain; Cerebellum; Diencephalon; gamma-Aminobutyric A

1974
Problems in interpreting neurochemical changes occurring in developing and aging animals.
    Progress in brain research, 1973, Volume: 40, Issue:0

    Topics: Aging; Animals; Brain; Cats; Cricetinae; DNA; gamma-Aminobutyric Acid; Glutamates; Haplorhini; Human

1973
Regional changes in amino acid content in developing rat brain.
    Journal of neurochemistry, 1974, Volume: 23, Issue:5

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Brain; Cerebellum; Cerebral Cortex; Ch

1974