gamma-aminobutyric acid has been researched along with Age-Related Memory Disorders in 86 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this article was to report a case of chorea that developed in an elderly man being treated with gabapentin for severe anxiety." | 7.75 | Chorea associated with gabapentin use in an elderly man. ( Attupurath, R; Aziz, R; Muralee, S; Tampi, RR; Wollman, D, 2009) |
| "This article reports a case of chorea in an elderly patient who was receiving gabapentin for the treatment of anxiety." | 7.75 | Chorea associated with gabapentin use in an elderly man. ( Attupurath, R; Aziz, R; Muralee, S; Tampi, RR; Wollman, D, 2009) |
| "Chorea is a hyperkinetic movement disorder characterized by irregular, flowing, nonstereotyped, random, involuntary movements." | 5.35 | Chorea associated with gabapentin use in an elderly man. ( Attupurath, R; Aziz, R; Muralee, S; Tampi, RR; Wollman, D, 2009) |
| "On evaluation, the patient had choreiform movements involving the neck, trunk, upper and lower extremities, and tongue." | 5.35 | Chorea associated with gabapentin use in an elderly man. ( Attupurath, R; Aziz, R; Muralee, S; Tampi, RR; Wollman, D, 2009) |
| "The purpose of this article was to report a case of chorea that developed in an elderly man being treated with gabapentin for severe anxiety." | 3.75 | Chorea associated with gabapentin use in an elderly man. ( Attupurath, R; Aziz, R; Muralee, S; Tampi, RR; Wollman, D, 2009) |
| "This article reports a case of chorea in an elderly patient who was receiving gabapentin for the treatment of anxiety." | 3.75 | Chorea associated with gabapentin use in an elderly man. ( Attupurath, R; Aziz, R; Muralee, S; Tampi, RR; Wollman, D, 2009) |
| "Using a repeated acquisition procedure in a 3-panel runway apparatus, the effect of WEB 1881 FU on impairment of working memory produced either by scopolamine or by cerebral ischemia was investigated in rats and compared with those of aniracetam and Ca hopantenate." | 3.68 | WEB 1881 FU ameliorates impairment of working memory induced by scopolamine and cerebral ischemia in the three-panel runway task. ( Kitajima, I; Ohno, M; Ueki, S; Yamamoto, T, 1990) |
| "Schizophrenia is a brain disorder associated with cognitive deficits that severely affect the patients' capacity for daily functioning." | 2.47 | GABA neuron alterations, cortical circuit dysfunction and cognitive deficits in schizophrenia. ( Fish, KN; Gonzalez-Burgos, G; Lewis, DA, 2011) |
| "Neonatal seizures commonly caused by hypoxia can lead to long-term neurological outcomes." | 1.91 | Fingolimod Administration Following Hypoxia Induced Neonatal Seizure Can Restore Impaired Long-term Potentiation and Memory Performance in Adult Rats. ( Ali Mard, S; Farbood, Y; Ghafouri, S; Hajipour, S; Khombi Shooshtari, M; Moradi Chameh, H; Sarkaki, A; Sistani Karampour, N, 2023) |
| "Seizure was induced in 24 male and female pups (6 in each experimental group) at postnatal day 10 (P10) by premixed gas (5% oxygen/ 95% nitrogen) in a hypoxic chamber for 15 minutes." | 1.91 | Fingolimod Administration Following Hypoxia Induced Neonatal Seizure Can Restore Impaired Long-term Potentiation and Memory Performance in Adult Rats. ( Ali Mard, S; Farbood, Y; Ghafouri, S; Hajipour, S; Khombi Shooshtari, M; Moradi Chameh, H; Sarkaki, A; Sistani Karampour, N, 2023) |
| "Sensory dysfunctions such as allodynia and hyperalgesia are only part of the symptoms associated with neuropathic pain that extend to memory and affectivity deficits." | 1.62 | 2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2- and H3 histamine autoreceptors. ( Amodeo, P; Belardo, C; Boccella, S; Calignano, A; Cristiano, C; de Novellis, V; Di Marzo, V; Guida, F; Iannotta, M; Iannotti, FA; Infantino, R; Luongo, L; Maione, S; Marabese, I; Paino, S; Palazzo, E; Ricciardi, F; Vitale, RM, 2021) |
| "Age and sex are risk factors of Alzheimer's disease (AD)." | 1.48 | Sex- and age-specific modulation of brain GABA levels in a mouse model of Alzheimer's disease. ( Alia, A; Hartlage-Rübsamen, M; Höfling, C; Matysik, J; Roy, U; Roβner, S; Stute, L, 2018) |
| "Neuropathic pain was induced by a chronic constriction injury of the sciatic nerve (CCI) and mechanical allodynia and the spatial memory was assessed using the Von Frey filaments and Morris water maze respectively." | 1.46 | In vivo evaluation of the hippocampal glutamate, GABA and the BDNF levels associated with spatial memory performance in a rodent model of neuropathic pain. ( Farahmandfar, M; Janzadeh, A; Naghdi, N; Nasirinezhad, F; Saffarpour, S; Shaabani, M, 2017) |
| "Inflammation is considered to be one of the crucial pathological factors associated with the development of Alzheimer's disease, although supportive experimental evidence remains undiscovered." | 1.46 | Immunological alteration & toxic molecular inductions leading to cognitive impairment & neurotoxicity in transgenic mouse model of Alzheimer's disease. ( Abdel-Rahman, E; Ahuja, M; Amin, R; Buabeid, M; Dhanasekaran, M; Majrashi, M; Parameshwaran, K; Pondugula, S; Ramesh, S; Suppiramaniam, V; Thiruchelvan, K, 2017) |
| "Pretreatment of sarcosine (600 mg/kg, i." | 1.43 | Effect of Sarcosine (a Glycine Transport 1 Inhibitor) and Risperidone (an Atypical antipsychotic Drug) on MK-801 Induced Learning and Memory Deficits in Rats. ( Ahmad, MA; Akhtar, M; Kumar, V; Najmi, AK, 2016) |
| " Results showed that chronic administration of ketamine can cause a variety of imbalances, and application of an antagonist of the D2 receptor in PFC can also induce imbalances but in a very different manner." | 1.43 | A heuristic model for working memory deficit in schizophrenia. ( Grace, AA; Pogarell, O; Qi, Z; Tretter, F; Voit, EO; Yu, GP, 2016) |
| "Depression during pregnancy has been linked to in utero stress and is associated with long-lasting symptoms in offspring, including anxiety, helplessness, attentional deficits, and social withdrawal." | 1.42 | Prenatal stress, regardless of concurrent escitalopram treatment, alters behavior and amygdala gene expression of adolescent female rats. ( Bourke, CH; Ehrlich, DE; Hazra, R; Jairam, N; Neigh, GN; Nemeth, CL; Owens, MJ; Rainnie, DG; Rowson, S; Ryan, SJ; Sholar, CA; Stowe, ZN, 2015) |
| " Since, 5-HT6 antagonists improved the effectiveness of gabapentinoids, reduction in the dosage and frequency of gabapentinoids treatment may reduce the side effects." | 1.42 | 5-HT6 receptor antagonist attenuates the memory deficits associated with neuropathic pain and improves the efficacy of gabapentinoids. ( Babu, VA; Bhyrapuneni, G; Goura, V; Jayarajan, P; Nirogi, R; Shinde, A; Yathavakilla, S, 2015) |
| "After infection with RML murine scrapie agent, transgenic (tg) mice expressing prion protein (PrP) without its glycophosphatidylinositol (GPI) membrane anchor (GPI(-/-) PrP tg mice) continue to make abundant amounts of the abnormally folded disease-associated PrPres but have a normal life span." | 1.35 | Scrapie-induced defects in learning and memory of transgenic mice expressing anchorless prion protein are associated with alterations in the gamma aminobutyric acid-ergic pathway. ( Bernard-Trifilo, J; Kunz, S; McGavern, D; Oldstone, MB; Sanchez-Alavez, M; Solforosi, L; Trifilo, MJ, 2008) |
| "Chorea is a hyperkinetic movement disorder characterized by irregular, flowing, nonstereotyped, random, involuntary movements." | 1.35 | Chorea associated with gabapentin use in an elderly man. ( Attupurath, R; Aziz, R; Muralee, S; Tampi, RR; Wollman, D, 2009) |
| "On evaluation, the patient had choreiform movements involving the neck, trunk, upper and lower extremities, and tongue." | 1.35 | Chorea associated with gabapentin use in an elderly man. ( Attupurath, R; Aziz, R; Muralee, S; Tampi, RR; Wollman, D, 2009) |
| "Chronic transauricular kindled seizure was induced by repeated application of initially subconvulsive electrical stimulation (40 mA, 0." | 1.34 | [Effects of acute maximal electroshock and chronic transauricular kindled seizures on learning abilities in Sprague-Dawley rats]. ( Chen, Z; Li, Q; Wu, DC; Zhang, Q, 2007) |
| "Chronic transauricular kindled seizures induced CA1 neuron damage and a decrease in histamine levels in the hippocampus." | 1.34 | [Effects of acute maximal electroshock and chronic transauricular kindled seizures on learning abilities in Sprague-Dawley rats]. ( Chen, Z; Li, Q; Wu, DC; Zhang, Q, 2007) |
| "Different types of kindling seizure produce different effects on cognitive behavior: (1) an acute MES impairs learning ability, which may be associated with an abnormal plasticity and an increase of GABA in the hippocampus; (2) the chronic transauricular kindled seizure impairs retrieval memory mainly, which may be related to CA1 neuron damage and a decrease in histaminergic activity in the hippocampus." | 1.34 | [Effects of acute maximal electroshock and chronic transauricular kindled seizures on learning abilities in Sprague-Dawley rats]. ( Chen, Z; Li, Q; Wu, DC; Zhang, Q, 2007) |
| "Chronic transauricular kindled seizures was induced by repeated application of initially subconvulsive electrical stimulation through ear-clip electrodes once every 24 h until the occurrence of 3 consecutive clonic-tonic seizures." | 1.33 | [Effect of chronic transauricular kindled seizures on passive-avoidance test memory retention in rats]. ( Chen, Z; Li, Q; Liu, LY; Zhou, WX; Zhu, YY, 2006) |
| "Chronic transauricular kindled seizures impaired passive-avoidance test memory retention in rats." | 1.33 | [Effect of chronic transauricular kindled seizures on passive-avoidance test memory retention in rats]. ( Chen, Z; Li, Q; Liu, LY; Zhou, WX; Zhu, YY, 2006) |
| "Chronic transauricular kindled seizure impaired passive-avoidance test memory retention, and it might be due to the damaged CA1 neurons and a decrease of histamine in the hippocampus induced by epilepsy." | 1.33 | [Effect of chronic transauricular kindled seizures on passive-avoidance test memory retention in rats]. ( Chen, Z; Li, Q; Liu, LY; Zhou, WX; Zhu, YY, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (3.49) | 18.7374 |
| 1990's | 5 (5.81) | 18.2507 |
| 2000's | 24 (27.91) | 29.6817 |
| 2010's | 45 (52.33) | 24.3611 |
| 2020's | 9 (10.47) | 2.80 |
| Authors | Studies |
|---|---|
| Yu, Y | 1 |
| Li, JJ | 1 |
| He, XQ | 1 |
| Lai, ZY | 1 |
| Hao, R | 1 |
| Qi, Y | 1 |
| Cao, DQ | 1 |
| Fu, M | 1 |
| Ma, H | 1 |
| Xie, QC | 1 |
| Sun, M | 1 |
| Huang, ZL | 1 |
| Jin, LJ | 1 |
| Sun, HH | 1 |
| Lu, N | 1 |
| Wang, R | 1 |
| Yung, WH | 1 |
| Huang, Y | 3 |
| Burjanadze, MA | 1 |
| Dashniani, MG | 1 |
| Solomonia, RO | 1 |
| Beselia, GV | 1 |
| Tsverava, L | 1 |
| Lagani, V | 1 |
| Chkhikvishvili, NC | 1 |
| Naneishvili, TL | 1 |
| Kruashvili, LB | 1 |
| Chighladze, MR | 1 |
| Wang, YS | 1 |
| Qiu, TY | 1 |
| Fu, Q | 1 |
| Xiong, SQ | 1 |
| Wang, ZZ | 1 |
| Lu, MF | 1 |
| Yang, JH | 1 |
| Hu, ZZ | 1 |
| Hajipour, S | 1 |
| Khombi Shooshtari, M | 1 |
| Farbood, Y | 1 |
| Ali Mard, S | 1 |
| Sarkaki, A | 1 |
| Moradi Chameh, H | 1 |
| Sistani Karampour, N | 1 |
| Ghafouri, S | 1 |
| Nkwingwa, BK | 1 |
| Wado, EK | 1 |
| Foyet, HS | 1 |
| Bouvourne, P | 1 |
| Jugha, VT | 1 |
| Mambou, AHMY | 1 |
| Bila, RB | 1 |
| Taiwe, GS | 1 |
| Wang, X | 1 |
| Zhao, Z | 1 |
| Guo, J | 1 |
| Mei, D | 1 |
| Duan, Y | 1 |
| Zhang, Y | 1 |
| Gou, L | 1 |
| Kotlinska, JH | 1 |
| Grochecki, P | 1 |
| Michalak, A | 1 |
| Pankowska, A | 1 |
| Kochalska, K | 1 |
| Suder, P | 1 |
| Ner-Kluza, J | 1 |
| Matosiuk, D | 1 |
| Marszalek-Grabska, M | 1 |
| Koh, MT | 1 |
| Branch, A | 1 |
| Haberman, R | 1 |
| Gallagher, M | 1 |
| Boccella, S | 1 |
| Guida, F | 1 |
| Iannotta, M | 1 |
| Iannotti, FA | 1 |
| Infantino, R | 1 |
| Ricciardi, F | 1 |
| Cristiano, C | 1 |
| Vitale, RM | 1 |
| Amodeo, P | 1 |
| Marabese, I | 1 |
| Belardo, C | 1 |
| de Novellis, V | 1 |
| Paino, S | 1 |
| Palazzo, E | 1 |
| Calignano, A | 1 |
| Di Marzo, V | 1 |
| Maione, S | 1 |
| Luongo, L | 1 |
| Saffarpour, S | 1 |
| Shaabani, M | 1 |
| Naghdi, N | 1 |
| Farahmandfar, M | 1 |
| Janzadeh, A | 1 |
| Nasirinezhad, F | 1 |
| Montes, S | 1 |
| Solís-Guillén, RDC | 1 |
| García-Jácome, D | 1 |
| Páez-Martínez, N | 1 |
| Cui, J | 1 |
| Ng, LJ | 1 |
| Volman, V | 1 |
| Llorente-Ovejero, A | 1 |
| Manuel, I | 1 |
| Giralt, MT | 1 |
| Rodríguez-Puertas, R | 1 |
| Liang, L | 1 |
| Zhou, H | 1 |
| Zhang, S | 1 |
| Yuan, J | 1 |
| Wu, H | 1 |
| Roy, U | 1 |
| Stute, L | 1 |
| Höfling, C | 1 |
| Hartlage-Rübsamen, M | 1 |
| Matysik, J | 1 |
| Roβner, S | 1 |
| Alia, A | 1 |
| Orfila, JE | 1 |
| Grewal, H | 1 |
| Dietz, RM | 1 |
| Strnad, F | 1 |
| Shimizu, T | 1 |
| Moreno, M | 1 |
| Schroeder, C | 1 |
| Yonchek, J | 1 |
| Rodgers, KM | 1 |
| Dingman, A | 1 |
| Bernard, TJ | 1 |
| Quillinan, N | 1 |
| Macklin, WB | 1 |
| Traystman, RJ | 1 |
| Herson, PS | 1 |
| Dargaei, Z | 1 |
| Bang, JY | 1 |
| Mahadevan, V | 1 |
| Khademullah, CS | 1 |
| Bedard, S | 1 |
| Parfitt, GM | 1 |
| Kim, JC | 1 |
| Woodin, MA | 1 |
| Cunha-Rodrigues, MC | 1 |
| Balduci, CTDN | 1 |
| Tenório, F | 1 |
| Barradas, PC | 1 |
| Watremez, W | 1 |
| Jackson, J | 1 |
| Almari, B | 1 |
| McLean, SL | 1 |
| Grayson, B | 1 |
| Neill, JC | 1 |
| Fischer, N | 1 |
| Allouche, A | 1 |
| Koziel, V | 1 |
| Pillot, T | 1 |
| Harte, MK | 1 |
| Newell, AJ | 1 |
| Lalitsasivimol, D | 1 |
| Willing, J | 1 |
| Gonzales, K | 1 |
| Waters, EM | 1 |
| Milner, TA | 1 |
| McEwen, BS | 1 |
| Wagner, CK | 1 |
| Ambrad Giovannetti, E | 1 |
| Fuhrmann, M | 1 |
| Leung, LS | 1 |
| Shen, B | 1 |
| Huszka, C | 1 |
| Thielen, JW | 1 |
| Gancheva, S | 1 |
| Hong, D | 1 |
| Rohani Rankouhi, S | 1 |
| Chen, B | 1 |
| Apostolopoulou, M | 1 |
| Anadol-Schmitz, E | 1 |
| Roden, M | 1 |
| Norris, DG | 1 |
| Tendolkar, I | 1 |
| Al-Hazmi, MA | 1 |
| Rawi, SM | 1 |
| Arafa, NM | 1 |
| Wagas, A | 1 |
| Montasser, AO | 1 |
| Hu, Y | 2 |
| Liu, M | 2 |
| Liu, P | 3 |
| Yan, JJ | 2 |
| Liu, MY | 1 |
| Zhang, GQ | 2 |
| Zhou, XJ | 1 |
| Yu, BY | 2 |
| Richetto, J | 1 |
| Calabrese, F | 1 |
| Meyer, U | 1 |
| Riva, MA | 1 |
| Begenisic, T | 1 |
| Baroncelli, L | 1 |
| Sansevero, G | 1 |
| Milanese, M | 1 |
| Bonifacino, T | 1 |
| Bonanno, G | 1 |
| Cioni, G | 1 |
| Maffei, L | 1 |
| Sale, A | 1 |
| Qiao, S | 1 |
| Peng, R | 1 |
| Yan, H | 1 |
| Gao, Y | 1 |
| Wang, C | 1 |
| Wang, S | 1 |
| Zou, Y | 1 |
| Xu, X | 1 |
| Zhao, L | 1 |
| Dong, J | 2 |
| Su, Z | 1 |
| Feng, X | 1 |
| Wang, L | 1 |
| Hu, X | 1 |
| Jo, S | 1 |
| Yarishkin, O | 1 |
| Hwang, YJ | 1 |
| Chun, YE | 1 |
| Park, M | 1 |
| Woo, DH | 1 |
| Bae, JY | 1 |
| Kim, T | 1 |
| Lee, J | 1 |
| Chun, H | 1 |
| Park, HJ | 1 |
| Lee, DY | 1 |
| Hong, J | 1 |
| Kim, HY | 1 |
| Oh, SJ | 1 |
| Park, SJ | 1 |
| Lee, H | 1 |
| Yoon, BE | 1 |
| Kim, Y | 2 |
| Jeong, Y | 1 |
| Shim, I | 1 |
| Bae, YC | 1 |
| Cho, J | 1 |
| Kowall, NW | 1 |
| Ryu, H | 1 |
| Hwang, E | 1 |
| Kim, D | 1 |
| Lee, CJ | 1 |
| Rudenko, A | 1 |
| Seo, J | 1 |
| Hu, J | 1 |
| Su, SC | 1 |
| de Anda, FC | 1 |
| Durak, O | 1 |
| Ericsson, M | 1 |
| Carlén, M | 1 |
| Tsai, LH | 1 |
| Kumar, V | 1 |
| Ahmad, MA | 1 |
| Najmi, AK | 1 |
| Akhtar, M | 1 |
| Cui, SQ | 1 |
| Wang, Q | 1 |
| Zheng, Y | 1 |
| Xiao, B | 1 |
| Sun, HW | 1 |
| Gu, XL | 1 |
| Zhang, YC | 1 |
| Fu, CH | 1 |
| Dong, PX | 1 |
| Wang, XM | 1 |
| Ehrlich, DE | 1 |
| Neigh, GN | 1 |
| Bourke, CH | 1 |
| Nemeth, CL | 1 |
| Hazra, R | 1 |
| Ryan, SJ | 1 |
| Rowson, S | 1 |
| Jairam, N | 1 |
| Sholar, CA | 1 |
| Rainnie, DG | 1 |
| Stowe, ZN | 1 |
| Owens, MJ | 1 |
| Sawano, E | 1 |
| Iwatani, K | 1 |
| Tominaga-Yoshino, K | 1 |
| Ogura, A | 1 |
| Tashiro, T | 1 |
| Li, JT | 1 |
| Zhao, YY | 1 |
| Wang, HL | 1 |
| Wang, XD | 1 |
| Su, YA | 1 |
| Si, TM | 1 |
| Solas, M | 1 |
| Puerta, E | 1 |
| Ramirez, MJ | 1 |
| Jayarajan, P | 1 |
| Nirogi, R | 1 |
| Shinde, A | 1 |
| Goura, V | 1 |
| Babu, VA | 1 |
| Yathavakilla, S | 1 |
| Bhyrapuneni, G | 1 |
| Tong, LM | 1 |
| Yoon, SY | 2 |
| Andrews-Zwilling, Y | 2 |
| Yang, A | 1 |
| Lin, V | 1 |
| Lei, H | 1 |
| Lee, V | 1 |
| MacKenzie, G | 1 |
| Hooper, A | 1 |
| Maguire, J | 1 |
| Qi, Z | 1 |
| Yu, GP | 1 |
| Tretter, F | 1 |
| Pogarell, O | 1 |
| Grace, AA | 1 |
| Voit, EO | 1 |
| Li, G | 2 |
| Lv, J | 1 |
| Wang, J | 1 |
| Wan, P | 1 |
| Li, Y | 2 |
| Jiang, H | 1 |
| Jin, Q | 1 |
| Ladrón de Guevara-Miranda, D | 1 |
| Millón, C | 1 |
| Rosell-Valle, C | 1 |
| Pérez-Fernández, M | 1 |
| Missiroli, M | 1 |
| Serrano, A | 1 |
| Pavón, FJ | 1 |
| Rodríguez de Fonseca, F | 1 |
| Martínez-Losa, M | 1 |
| Álvarez-Dolado, M | 1 |
| Santín, LJ | 1 |
| Castilla-Ortega, E | 1 |
| Ahuja, M | 1 |
| Buabeid, M | 1 |
| Abdel-Rahman, E | 1 |
| Majrashi, M | 1 |
| Parameshwaran, K | 1 |
| Amin, R | 1 |
| Ramesh, S | 1 |
| Thiruchelvan, K | 1 |
| Pondugula, S | 1 |
| Suppiramaniam, V | 1 |
| Dhanasekaran, M | 1 |
| Trifilo, MJ | 1 |
| Sanchez-Alavez, M | 1 |
| Solforosi, L | 1 |
| Bernard-Trifilo, J | 1 |
| Kunz, S | 1 |
| McGavern, D | 1 |
| Oldstone, MB | 1 |
| Sunyer, B | 1 |
| Shim, KS | 1 |
| An, G | 1 |
| Höger, H | 1 |
| Lubec, G | 1 |
| Staley, KJ | 1 |
| Anderson, AE | 1 |
| Frauenknecht, K | 1 |
| Plaschke, K | 1 |
| Sommer, C | 1 |
| Gupta, N | 1 |
| Zhang, H | 1 |
| Puighermanal, E | 1 |
| Marsicano, G | 1 |
| Busquets-Garcia, A | 1 |
| Lutz, B | 1 |
| Maldonado, R | 1 |
| Ozaita, A | 1 |
| Mackie, K | 1 |
| Katona, I | 1 |
| Attupurath, R | 1 |
| Aziz, R | 1 |
| Wollman, D | 1 |
| Muralee, S | 1 |
| Tampi, RR | 1 |
| Blanc, F | 1 |
| Ruppert, E | 1 |
| Kleitz, C | 1 |
| Valenti, MP | 1 |
| Cretin, B | 1 |
| Humbel, RL | 1 |
| Honnorat, J | 1 |
| Namer, IJ | 1 |
| Hirsch, E | 1 |
| Manning, L | 1 |
| de Seze, J | 1 |
| Belforte, JE | 1 |
| Zsiros, V | 1 |
| Sklar, ER | 1 |
| Jiang, Z | 1 |
| Yu, G | 1 |
| Quinlan, EM | 1 |
| Nakazawa, K | 1 |
| Braden, BB | 1 |
| Talboom, JS | 1 |
| Crain, ID | 1 |
| Simard, AR | 1 |
| Lukas, RJ | 1 |
| Prokai, L | 1 |
| Scheldrup, MR | 1 |
| Bowman, BL | 1 |
| Bimonte-Nelson, HA | 1 |
| Blake, MG | 1 |
| Boccia, MM | 1 |
| Carcaboso, AM | 1 |
| Chiappetta, DA | 1 |
| Höcht, C | 1 |
| Krawczyk, MC | 1 |
| Sosnik, A | 1 |
| Baratti, CM | 1 |
| Lecourtier, L | 1 |
| de Vasconcelos, AP | 1 |
| Leroux, E | 1 |
| Cosquer, B | 1 |
| Geiger, K | 1 |
| Lithfous, S | 1 |
| Cassel, JC | 1 |
| Pang, KC | 1 |
| Jiao, X | 1 |
| Sinha, S | 1 |
| Beck, KD | 1 |
| Servatius, RJ | 1 |
| Bien-Ly, N | 1 |
| Xu, Q | 1 |
| Bernardo, A | 1 |
| Zwilling, D | 1 |
| Yan, TX | 1 |
| Chen, L | 1 |
| Li, E | 1 |
| Kim, DH | 1 |
| Cai, M | 1 |
| Lee, S | 1 |
| Lim, E | 1 |
| Hoon Ryu, J | 1 |
| Unterman, TG | 1 |
| Park, S | 1 |
| Luo, J | 1 |
| Min, S | 1 |
| Wei, K | 1 |
| Li, P | 1 |
| Liu, YF | 1 |
| Gonzalez-Burgos, G | 2 |
| Fish, KN | 1 |
| Lewis, DA | 3 |
| Heo, H | 1 |
| Yoo, M | 1 |
| Han, D | 1 |
| Cho, Y | 1 |
| Joung, I | 1 |
| Kwon, YK | 1 |
| Zarrindast, MR | 1 |
| Shamsi, T | 1 |
| Azarmina, P | 1 |
| Rostami, P | 1 |
| Shafaghi, B | 1 |
| Inada, K | 1 |
| Ishigooka, J | 1 |
| Rosi, S | 1 |
| Giovannini, MG | 1 |
| Lestage, PJ | 1 |
| Muñoz, C | 1 |
| Corte, LD | 1 |
| Pepeu, G | 1 |
| Volk, DW | 1 |
| Hashimoto, T | 1 |
| Sabolek, HR | 1 |
| Bunce, JG | 1 |
| Giuliana, D | 1 |
| Chrobak, JJ | 1 |
| Li, Q | 2 |
| Liu, LY | 1 |
| Zhu, YY | 1 |
| Zhou, WX | 1 |
| Chen, Z | 2 |
| Guerrini, G | 1 |
| Ciciani, G | 1 |
| Cambi, G | 1 |
| Bruni, F | 1 |
| Selleri, S | 1 |
| Besnard, F | 1 |
| Montali, M | 1 |
| Martini, C | 1 |
| Ghelardini, C | 1 |
| Galeotti, N | 1 |
| Costanzo, A | 1 |
| Wu, DC | 1 |
| Zhang, Q | 1 |
| Krebs-Kraft, DL | 1 |
| Parent, MB | 1 |
| Rueda, N | 1 |
| Flórez, J | 1 |
| Martínez-Cué, C | 1 |
| Ohtomo, E | 1 |
| Heim, C | 2 |
| Sieklucka, M | 2 |
| Sontag, KH | 2 |
| Ogasawara, T | 1 |
| Itoh, Y | 1 |
| Tamura, M | 1 |
| Mushiroi, T | 1 |
| Ukai, Y | 1 |
| Kise, M | 1 |
| Kimura, K | 1 |
| Zhang, J | 1 |
| Lan, J | 1 |
| Kurz, T | 1 |
| Riederer, P | 1 |
| Gerlach, M | 1 |
| Sun, MK | 2 |
| Zhao, WQ | 1 |
| Nelson, TJ | 1 |
| Alkon, DL | 2 |
| Johansson, IM | 1 |
| Birzniece, V | 1 |
| Lindblad, C | 1 |
| Olsson, T | 1 |
| Bäckström, T | 1 |
| Makeeva, VL | 1 |
| Abe, E | 1 |
| Murai, S | 1 |
| Masuda, Y | 1 |
| Saito, H | 1 |
| Itoh, T | 1 |
| Kamei, C | 1 |
| Tsujimoto, S | 1 |
| Tasaka, K | 1 |
| Ohno, M | 1 |
| Yamamoto, T | 1 |
| Kitajima, I | 1 |
| Ueki, S | 1 |
| Barkai, AI | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Longitudinal Early-onset Alzheimer's Disease Study Protocol[NCT03507257] | 700 participants (Anticipated) | Observational | 2018-04-30 | Recruiting | |||
| Treatment of Cognitive Disability in Schizophrenia With a GABA-A Alpha2/3 Receptor Agonist[NCT00129441] | Phase 2 | 16 participants (Actual) | Interventional | 2005-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
For the AX Continuous Performance Test, subjects are required to maintain an attentional set across a delay interval in order to overcome a prepotent response tendency (target responses are required when an X is presented but only in the context of a preceding A; non-target conditions are AY, BX and BY). The dependent measure was d-prime at the long delay (calculated as AX hits minus BX false alarms, which is particularly sensitive to context processing impairments in individuals with schizophrenia. (NCT00129441)
Timeframe: Week 4
| Intervention | d-prime (Mean) |
|---|---|
| L-830982 | 1.9 |
| Placebo | 0.7 |
The Brief Psychiatric Rating Scale-anchored (BPRS; Overall and Gorham, 1962; Woerner, Mannuzza, Kane, 1988) is an 18-item scale that is among the most widely used measure of psychopathology. Scores range from 1-7, with higher scores reflecting greater pathology. A total score is derived from the sum of all 18 items (possible scores range from 18-126). It relies on clinical judgment in the assessment of key areas of psychopathology (depression, anxiety, psychosis). (NCT00129441)
Timeframe: Week 4
| Intervention | Scores on a scale (Mean) |
|---|---|
| L-830982 | 26.3 |
| Placebo | 27.0 |
The N-back task is a sequential-letter memory task for which working memory load is varied, as the respondent must indicate when the current stimulus matches the one from 'n' steps earlier in the sequence. The dependent measure for the N-back task was performance in the 2-back condition, which provides the best index of performance and dorsolateral prefrontal cortex disturbances in subjects with schizophrenia. (NCT00129441)
Timeframe: Week 4
| Intervention | proportion of errors (Mean) |
|---|---|
| L-830982 | 0.239 |
| Placebo | 0.297 |
The N-back task is a sequential-letter memory task for which working memory load is varied, as the respondent must indicate when the current stimulus matches the one from 'n' steps earlier in the sequence. The dependent measure for the N-back task was performance in the 2-back condition, which provides the best index of performance and dorsolateral prefrontal cortex disturbances in subjects with schizophrenia. (NCT00129441)
Timeframe: Week 4
| Intervention | msec (Mean) |
|---|---|
| L-830982 | 786 |
| Placebo | 684 |
The POP task is a cued stimulus-response reversal paradigm that, similar to the AX Continuous Performance Test, requires increases in cognitive control through the maintenance and use of context information to overcome prepotent response tendencies. (NCT00129441)
Timeframe: Week 4
| Intervention | msec (Mean) |
|---|---|
| L-830982 | 57 |
| Placebo | 66 |
The POP task is a cued stimulus-response reversal paradigm that, similar to the AX Continuous Performance Test, requires increases in cognitive control through the maintenance and use of context information to overcome prepotent response tendencies. (NCT00129441)
Timeframe: Week 4
| Intervention | proportion of errors (Mean) |
|---|---|
| L-830982 | 0.042 |
| Placebo | 0.031 |
"The Delayed Memory Index consists of verbal and nonverbal recall tasks (words, drawings) that the subject views early in the evaluation and without warning, is asked to recall ~1/2 hr later. Scores are expressed as standardized scores normalized to a population mean of 100, with a standard deviation of 15 (possible scores between 40-135). Higher scores reflect better performance. Subjects received the A form at baseline and wk-4 visit and the B form at the wk-2 visit (A/B forms are equivalent alternate forms, which allow for retesting patients without the confound of practice effects)." (NCT00129441)
Timeframe: Week 4
| Intervention | Standard Score (Mean) |
|---|---|
| L-830982 | 85.3 |
| Placebo | 63.8 |
"Five index scores are computed from the RBANS (immediate memory, language, visuospatial, attention, delayed memory) that are combined to provide the Total Score. The Total Score is expressed as a standardized score normalized to a population mean of 100, with a standard deviation of 15 (possible scores 40-135). Higher scores reflect better performance. All subjects received the A form at baseline and the wk-4 visit and the B form at the wk-2 visit (the A/B forms are equivalent alternate forms, which allow for retesting patients without the confound of practice effects)." (NCT00129441)
Timeframe: Week 4
| Intervention | Standard Score (Mean) |
|---|---|
| L-830982 | 76.7 |
| Placebo | 70.8 |
8 reviews available for gamma-aminobutyric acid and Age-Related Memory Disorders
| Article | Year |
|---|---|
Unravelling biological roles and mechanisms of GABA
Topics: Depression; gamma-Aminobutyric Acid; Humans; Memory Disorders; Receptors, GABA-B; Synapses | 2022 |
Unsupervised excitation: GABAergic dysfunctions in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Disease Models, Animal; GABAergic Neurons; | 2019 |
Treatment Options in Alzheimer´s Disease: The GABA Story.
Topics: Aged; Alzheimer Disease; Animals; Cognition Disorders; Drug Design; gamma-Aminobutyric Acid; Humans; | 2015 |
GABA neuron alterations, cortical circuit dysfunction and cognitive deficits in schizophrenia.
Topics: Animals; Biological Clocks; Cerebral Cortex; Cognition Disorders; Cortical Synchronization; Disease | 2011 |
[Dementia induced by antianxiety drugs].
Topics: Aging; Anti-Anxiety Agents; Benzodiazepines; Chlorides; Dementia; GABA-A Receptor Agonists; gamma-Am | 2004 |
Selective alterations in prefrontal cortical GABA neurotransmission in schizophrenia: a novel target for the treatment of working memory dysfunction.
Topics: Animals; GABA Agents; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamate De | 2004 |
Pathophysiologically based treatment interventions in schizophrenia.
Topics: Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Memory Disorders; Models, Neurological; Pr | 2006 |
[Recent advances in brain metabolic activators].
Topics: Aged; Amantadine; Animals; Brain; Cats; Cerebrovascular Circulation; Cerebrovascular Disorders; Clin | 1984 |
1 trial available for gamma-aminobutyric acid and Age-Related Memory Disorders
| Article | Year |
|---|---|
[Recent advances in brain metabolic activators].
Topics: Aged; Amantadine; Animals; Brain; Cats; Cerebrovascular Circulation; Cerebrovascular Disorders; Clin | 1984 |
78 other studies available for gamma-aminobutyric acid and Age-Related Memory Disorders
| Article | Year |
|---|---|
5-HT
Topics: Animals; CA1 Region, Hippocampal; gamma-Aminobutyric Acid; Hippocampus; Humans; Long-Term Potentiati | 2022 |
Age-related changes in medial septal cholinergic and GABAergic projection neurons and hippocampal neurotransmitter receptors: relationship with memory impairment.
Topics: Animals; Cholinergic Agents; gamma-Aminobutyric Acid; Hippocampus; Humans; Maze Learning; Memory Dis | 2022 |
Fingolimod Administration Following Hypoxia Induced Neonatal Seizure Can Restore Impaired Long-term Potentiation and Memory Performance in Adult Rats.
Topics: Animals; Epilepsy; Female; Fingolimod Hydrochloride; gamma-Aminobutyric Acid; Hippocampus; Hypoxia; | 2023 |
Ameliorative effects of Albizia adianthifolia aqueous extract against pentylenetetrazole-induced epilepsy and associated memory loss in mice: Role of GABAergic, antioxidant defense and anti-inflammatory systems.
Topics: Albizzia; Amnesia; Animals; Anti-Inflammatory Agents; Anticonvulsants; Antioxidants; Epilepsy; gamma | 2023 |
GABA
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Humans; | 2023 |
Neonatal Maternal Separation Induces Sexual Dimorphism in Brain Development: The Influence on Amino Acid Levels and Cognitive Disorders.
Topics: Amino Acids; Animals; Brain; Cognitive Dysfunction; Female; gamma-Aminobutyric Acid; Glutamic Acid; | 2023 |
Significance of inhibitory recruitment in aging with preserved cognition: limiting gamma-aminobutyric acid type A α5 function produces memory impairment.
Topics: Aging; Animals; Cognitive Reserve; gamma-Aminobutyric Acid; Hippocampus; Male; Memory Disorders; Neu | 2020 |
2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2- and H3 histamine autoreceptors.
Topics: Amino Acid Sequence; Animals; Anxiety; Behavior, Animal; Chlorocebus aethiops; Cognition; COS Cells; | 2021 |
In vivo evaluation of the hippocampal glutamate, GABA and the BDNF levels associated with spatial memory performance in a rodent model of neuropathic pain.
Topics: Analysis of Variance; Animals; Brain-Derived Neurotrophic Factor; Chromatography, High Pressure Liqu | 2017 |
Environmental enrichment reverses memory impairment induced by toluene in mice.
Topics: Administration, Inhalation; Animals; Environment Design; gamma-Aminobutyric Acid; Glutamic Acid; Hip | 2017 |
Callosal injury-induced working memory impairment: a computational network modeling study.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Computer Simulation; Corpus Callo | 2017 |
Increase in cortical endocannabinoid signaling in a rat model of basal forebrain cholinergic dysfunction.
Topics: Animals; Antibodies, Monoclonal; Basal Forebrain; Cerebral Cortex; Cholinergic Neurons; Disease Mode | 2017 |
Effects of gut microbiota disturbance induced in early life on the expression of extrasynaptic GABA-A receptor α5 and δ subunits in the hippocampus of adult rats.
Topics: Animals; Behavior, Animal; Brain; gamma-Aminobutyric Acid; Gastrointestinal Microbiome; Hippocampus; | 2017 |
Sex- and age-specific modulation of brain GABA levels in a mouse model of Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Amyloidogenic Proteins; Animals; Astrocytes; Brain; Disease Models, Animal | 2018 |
Delayed inhibition of tonic inhibition enhances functional recovery following experimental ischemic stroke.
Topics: Animals; Brain Ischemia; Cognition; gamma-Aminobutyric Acid; Hippocampus; Long-Term Potentiation; Ma | 2019 |
Restoring GABAergic inhibition rescues memory deficits in a Huntington's disease mouse model.
Topics: Animals; Bumetanide; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Hippocampus; Humans; H | 2018 |
GABA function may be related to the impairment of learning and memory caused by systemic prenatal hypoxia-ischemia.
Topics: Animals; Female; gamma-Aminobutyric Acid; Hippocampus; Hypoxia-Ischemia, Brain; Learning; Maze Learn | 2018 |
Stabilized Low-n Amyloid-β Oligomers Induce Robust Novel Object Recognition Deficits Associated with Inflammatory, Synaptic, and GABAergic Dysfunction in the Rat.
Topics: Amyloid beta-Peptides; Animals; Brain; Cognition; Disease Models, Animal; Donepezil; Female; gamma-A | 2018 |
Progesterone receptor expression in cajal-retzius cells of the developing rat dentate gyrus: Potential role in hippocampus-dependent memory.
Topics: Animals; Behavior, Animal; Dentate Gyrus; Female; gamma-Aminobutyric Acid; Hippocampus; Interneurons | 2018 |
Long-lasting disruption of spatial memory by GABA
Topics: Animals; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Male; Maze Learning; Mem | 2019 |
Higher GABA concentration in the medial prefrontal cortex of Type 2 diabetes patients is associated with episodic memory dysfunction.
Topics: Adult; Diabetes Mellitus, Type 2; Female; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Spectr | 2019 |
The potent effects of ginseng root extract and memantine on cognitive dysfunction in male albino rats.
Topics: Acetylcholinesterase; Animals; Brain; Dopamine; Dose-Response Relationship, Drug; gamma-Aminobutyric | 2015 |
Effect of kai xin san on learning and memory in a rat model of paradoxical sleep deprivation.
Topics: Animals; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Cognition Disorders; Cyclic AMP | 2013 |
Prenatal versus postnatal maternal factors in the development of infection-induced working memory impairments in mice.
Topics: Animals; Animals, Newborn; Down-Regulation; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase | 2013 |
Fluoxetine in adulthood normalizes GABA release and rescues hippocampal synaptic plasticity and spatial memory in a mouse model of Down syndrome.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Biophysics; Disease Models, | 2014 |
Reduction of phosphorylated synapsin I (ser-553) leads to spatial memory impairment by attenuating GABA release after microwave exposure in Wistar rats.
Topics: Animals; gamma-Aminobutyric Acid; Male; Memory Disorders; Microwaves; PC12 Cells; Phosphorylation; R | 2014 |
GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Astrocytes; | 2014 |
Loss of cyclin-dependent kinase 5 from parvalbumin interneurons leads to hyperinhibition, decreased anxiety, and memory impairment.
Topics: Animals; Anxiety; Behavior, Animal; Cyclin-Dependent Kinase 5; gamma-Aminobutyric Acid; Inhibition, | 2015 |
Effect of Sarcosine (a Glycine Transport 1 Inhibitor) and Risperidone (an Atypical antipsychotic Drug) on MK-801 Induced Learning and Memory Deficits in Rats.
Topics: Animals; Antipsychotic Agents; Dizocilpine Maleate; gamma-Aminobutyric Acid; Glycine; Glycine Plasma | 2016 |
Puerarin protects against damage to spatial learning and memory ability in mice with chronic alcohol poisoning.
Topics: Alcoholism; Animals; Cerebral Cortex; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorb | 2015 |
Prenatal stress, regardless of concurrent escitalopram treatment, alters behavior and amygdala gene expression of adolescent female rats.
Topics: Amygdala; Animals; Anxiety; Citalopram; Corticosterone; Disease Models, Animal; Estradiol; Female; g | 2015 |
Reduction in NPY-positive neurons and dysregulation of excitability in young senescence-accelerated mouse prone 8 (SAMP8) hippocampus precede the onset of cognitive impairment.
Topics: Aging; Animals; Behavior, Animal; Cognition Disorders; Cyclic AMP Response Element-Binding Protein; | 2015 |
Long-term effects of neonatal exposure to MK-801 on recognition memory and excitatory-inhibitory balance in rat hippocampus.
Topics: Animals; Animals, Newborn; Cell Count; Disease Models, Animal; Dizocilpine Maleate; Exploratory Beha | 2015 |
5-HT6 receptor antagonist attenuates the memory deficits associated with neuropathic pain and improves the efficacy of gabapentinoids.
Topics: Amines; Animals; Cognition; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Gabapent | 2015 |
Enhancing GABA Signaling during Middle Adulthood Prevents Age-Dependent GABAergic Interneuron Decline and Learning and Memory Deficits in ApoE4 Mice.
Topics: Aging; Animals; Apolipoprotein E4; Female; GABA Agonists; gamma-Aminobutyric Acid; Gene Knock-In Tec | 2016 |
Reduced tonic inhibition in the dentate gyrus contributes to chronic stress-induced impairments in learning and memory.
Topics: Animals; Chronic Disease; Dentate Gyrus; Female; gamma-Aminobutyric Acid; Learning; Learning Disabil | 2016 |
A heuristic model for working memory deficit in schizophrenia.
Topics: Brain; Computer Simulation; gamma-Aminobutyric Acid; Glutamic Acid; Heuristics; Humans; Ketamine; Me | 2016 |
GABAB receptors in the hippocampal dentate gyrus are involved in spatial learning and memory impairment in a rat model of vascular dementia.
Topics: Animals; Baclofen; Dementia, Vascular; Dentate Gyrus; Disease Models, Animal; GABA Antagonists; GABA | 2016 |
Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis.
Topics: Adaptation, Physiological; Aging; Animals; Behavior, Animal; Cocaine; Cognition Disorders; Dentate G | 2017 |
Immunological alteration & toxic molecular inductions leading to cognitive impairment & neurotoxicity in transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Cognition D | 2017 |
Scrapie-induced defects in learning and memory of transgenic mice expressing anchorless prion protein are associated with alterations in the gamma aminobutyric acid-ergic pathway.
Topics: Animals; Behavior, Animal; Brain; Electrophysiology; gamma-Aminobutyric Acid; Glycosylphosphatidylin | 2008 |
Hippocampal levels of phosphorylated protein kinase A (phosphor-S96) are linked to spatial memory enhancement by SGS742.
Topics: Amino Acid Sequence; Animals; Cyclic AMP-Dependent Protein Kinases; GABA Antagonists; GABA-B Recepto | 2009 |
Hyperactive interneurons impair learning in a neurofibromatosis model.
Topics: Animals; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; gamma-Aminobutyric Acid | 2009 |
Transient oligemia is associated with long-term changes in binding densities of cortical inhibitory GABAA receptors in the rat brain.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Disease Models, Animal; Down-Regulation; GABA Agonis | 2009 |
Behavioral and neurochemical effects of acute putrescine depletion by difluoromethylornithine in rats.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Eflornithine; Enzyme Inhibitors; Exploratory Beh | 2009 |
Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling.
Topics: Animals; Anisomycin; Central Nervous System Agents; Cognition; Dronabinol; gamma-Aminobutyric Acid; | 2009 |
Get stoned in GABAergic synapses.
Topics: Animals; Axons; Carrier Proteins; Dronabinol; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; I | 2009 |
Chorea associated with gabapentin use in an elderly man.
Topics: Aged; Amines; Analgesics; Anti-Dyskinesia Agents; Anxiety; Chorea; Cognition Disorders; Cyclohexanec | 2009 |
Acute limbic encephalitis and glutamic acid decarboxylase antibodies: a reality?
Topics: Acute Disease; Adult; Anti-Inflammatory Agents; Autoantibodies; Biomarkers; Electroencephalography; | 2009 |
Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes.
Topics: Action Potentials; Analysis of Variance; Animals; Animals, Newborn; Cerebral Cortex; Disease Models, | 2010 |
Medroxyprogesterone acetate impairs memory and alters the GABAergic system in aged surgically menopausal rats.
Topics: Animals; Contraceptive Agents, Female; Female; gamma-Aminobutyric Acid; Hippocampus; Medroxyprogeste | 2010 |
Novel long-term anticonvulsant treatment with gabapentin without causing memory impairment in mice.
Topics: Amines; Animals; Anticonvulsants; Cognition Disorders; Cyclohexanecarboxylic Acids; Disease Models, | 2010 |
Septohippocampal pathways contribute to system consolidation of a spatial memory: sequential implication of GABAergic and cholinergic neurons.
Topics: Acetylcholine; Animals; Cholinergic Neurons; GABAergic Neurons; gamma-Aminobutyric Acid; Hippocampus | 2011 |
Damage of GABAergic neurons in the medial septum impairs spatial working memory and extinction of active avoidance: effects on proactive interference.
Topics: Animals; Choline O-Acetyltransferase; Diagonal Band of Broca; Disease Models, Animal; GABA Plasma Me | 2011 |
Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.
Topics: Age Factors; Analysis of Variance; Animals; Apolipoprotein E4; Cells, Cultured; Dentate Gyrus; Elect | 2010 |
Hippocampus-dependent spatial learning and memory are impaired in growth hormone-deficient spontaneous dwarf rats.
Topics: Acetylcholine; Animals; Choline O-Acetyltransferase; Dwarfism, Pituitary; gamma-Aminobutyric Acid; G | 2011 |
Propofol protects against impairment of learning-memory and imbalance of hippocampal Glu/GABA induced by electroconvulsive shock in depressed rats.
Topics: Animals; Cognition; Depression; Down-Regulation; Electroconvulsive Therapy; Electroshock; gamma-Amin | 2011 |
Upregulation of TrkB by forskolin facilitated survival of MSC and functional recovery of memory deficient model rats.
Topics: Adenylyl Cyclases; Animals; Brain-Derived Neurotrophic Factor; Cell Survival; Colforsin; Disease Mod | 2013 |
[Effect and mechanism of dingzhixiao wan on scopolamine-induced learning-memory impairment in mice].
Topics: Animals; Brain Chemistry; Dopamine; Drugs, Chinese Herbal; gamma-Aminobutyric Acid; Glutamic Acid; L | 2012 |
GABAergic system and imipramine-induced impairment of memory retention in rats.
Topics: Animals; Avoidance Learning; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; GABA | 2004 |
S 18986, a positive modulator of AMPA receptors with cognition-enhancing properties, increases ACh release in the hippocampus of young and aged rat.
Topics: Acetylcholine; Aging; Animals; Avoidance Learning; Benzothiadiazines; Dose-Response Relationship, Dr | 2004 |
Within-subject memory decline in middle-aged rats: effects of intraseptal tacrine.
Topics: Acetylcholine; Aging; Animals; Catheterization; Cholinergic Fibers; Drug Administration Routes; Earl | 2004 |
[Effect of chronic transauricular kindled seizures on passive-avoidance test memory retention in rats].
Topics: Animals; Avoidance Learning; gamma-Aminobutyric Acid; Hippocampus; Histamine; Kindling, Neurologic; | 2006 |
Novel 3-iodo-8-ethoxypyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide as promising lead for design of alpha5-inverse agonist useful tools for therapy of mnemonic damage.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Ataxia; Diazepam; Drug Design; GABA Agonists; gamma-Aminobuty | 2007 |
[Effects of acute maximal electroshock and chronic transauricular kindled seizures on learning abilities in Sprague-Dawley rats].
Topics: Animals; Chronic Disease; Electric Stimulation; Electrodes; Electroshock; gamma-Aminobutyric Acid; H | 2007 |
Hippocampal infusions of glucose reverse memory deficits produced by co-infusions of a GABA receptor agonist.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; GABA Agonists; gamma-A | 2008 |
Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome.
Topics: Acetylcholine; Animals; Brain; Cholinesterase Inhibitors; Cognition Disorders; Dementia; Disease Mod | 2008 |
Levemopamil injection after cerebral oligemia reduces spatial memory deficits in rats.
Topics: Acetylcholine; Animals; Brain Chemistry; Calcium Channel Blockers; Carotid Arteries; gamma-Aminobuty | 1994 |
Involvement of cholinergic and GABAergic systems in the reversal of memory disruption by NS-105, a cognition enhancer.
Topics: Acetylcholine; Animals; Avoidance Learning; Basal Ganglia; Cerebral Cortex; Cognition; Electroshock; | 1999 |
Cerebral oligaemia episode triggers free radical formation and late cognitive deficiencies.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aspartic Acid; Carotid Stenosis; Cognition Disorders; Corpu | 2000 |
Theta rhythm of hippocampal CA1 neuron activity: gating by GABAergic synaptic depolarization.
Topics: Acetazolamide; Animals; Bicarbonates; Biological Clocks; Carbonic Anhydrase Inhibitors; Carbonic Anh | 2001 |
Allopregnanolone inhibits learning in the Morris water maze.
Topics: Anesthetics; Animals; Brain; Corticosterone; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Hipp | 2002 |
Impairment of hippocampal CA1 heterosynaptic transformation and spatial memory by beta-amyloid(25-35).
Topics: Amyloid beta-Peptides; Animals; Carbachol; Cholinergic Agonists; Excitatory Postsynaptic Potentials; | 2002 |
[Neurologic adverse manifestations and complications of ambulatory therapy with psychotropic drugs in the late stages].
Topics: Adult; Aged; Antidepressive Agents; Autonomic Nervous System; Basal Ganglia Diseases; Cognition Diso | 1978 |
Reversal by 3,3',5-triido-L-thyronine of the working memory deficit, and the decrease in acetylcholine, glutamate and gamma-aminobutyric acid induced by ethylcholine aziridinium ion in mice.
Topics: Acetylcholine; Animals; Aspartic Acid; Aziridines; Behavior, Animal; Brain; Choline; gamma-Aminobuty | 1992 |
Effects of cholinergic drugs and cerebral metabolic activators on memory impairment in old rats.
Topics: Acetylcholine; Aging; Animals; Benzoquinones; Brain; Central Nervous System Agents; gamma-Aminobutyr | 1990 |
WEB 1881 FU ameliorates impairment of working memory induced by scopolamine and cerebral ischemia in the three-panel runway task.
Topics: Animals; Brain Ischemia; gamma-Aminobutyric Acid; Male; Memory; Memory Disorders; Pantothenic Acid; | 1990 |
Biochemical and neuroendocrinological effects of electroconvulsive therapy. Discussion of Part II.
Topics: Animals; Brain; Cerebral Cortex; Electroconvulsive Therapy; gamma-Aminobutyric Acid; Memory Disorder | 1986 |