gamma-aminobutyric acid has been researched along with Affective Disorders, Psychotic in 10 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Affective Disorders, Psychotic: Disorders in which the essential feature is a severe disturbance in mood (depression, anxiety, elation, and excitement) accompanied by psychotic symptoms such as delusions, hallucinations, gross impairment in reality testing, etc.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Schizophrenia and affective psychoses share the following: 1) several treatments are effective in both, 2) similar modes of inheritance, 3) congruent seasonal birth excesses, 4) enlarged cerebral ventricles and cerebellar vermian atrophy, 5) dexamethasone non-suppression." | 2.38 | A review of evidence for GABergic predominance/glutamatergic deficit as a common etiological factor in both schizophrenia and affective psychoses: more support for a continuum hypothesis of "functional" psychosis. ( Saederup, E; Squires, RF, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (50.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Drevets, WC | 1 |
| Post, RM | 1 |
| Emrich, HM | 2 |
| von Zerssen, D | 2 |
| Kissling, W | 2 |
| Möller, HJ | 2 |
| Windorfer, A | 1 |
| Gillman, MA | 1 |
| Lichtigfeld, FJ | 1 |
| Gerner, RH | 1 |
| Hare, TA | 1 |
| Petty, F | 2 |
| Krupitskiĭ, EM | 1 |
| Burakov, AM | 1 |
| Karandashova, GF | 1 |
| Lebedev, VP | 1 |
| Katsnel'son, IaS | 1 |
| Nikitina, ZS | 1 |
| Grinenko, AIa | 1 |
| Borodkin, IuS | 1 |
| Squires, RF | 1 |
| Saederup, E | 1 |
| Kramer, GL | 1 |
| Dunnam, D | 1 |
| Rush, AJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776] | Phase 2 | 54 participants (Actual) | Interventional | 2017-08-07 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 3.90 |
| Gabapentin | 3.93 |
| Placebo Oral Tablet | 3.73 |
Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 21.59 |
| Gabapentin | 21.69 |
| Placebo Oral Tablet | 22.25 |
3 reviews available for gamma-aminobutyric acid and Affective Disorders, Psychotic
| Article | Year |
|---|---|
Use of the anticonvulsant carbamazepine in primary and secondary affective illness: clinical and theoretical implications.
Topics: Affective Disorders, Psychotic; Animals; Antidepressive Agents; Antipsychotic Agents; Bipolar Disord | 1982 |
Plasma concentrations of gamma-aminobutyric acid (GABA) and mood disorders: a blood test for manic depressive disease?
Topics: Affective Disorders, Psychotic; Bipolar Disorder; Brain; Drug Stability; gamma-Aminobutyric Acid; Hu | 1994 |
A review of evidence for GABergic predominance/glutamatergic deficit as a common etiological factor in both schizophrenia and affective psychoses: more support for a continuum hypothesis of "functional" psychosis.
Topics: Affective Disorders, Psychotic; Antipsychotic Agents; Brain; gamma-Aminobutyric Acid; Glutamates; Hu | 1991 |
3 trials available for gamma-aminobutyric acid and Affective Disorders, Psychotic
| Article | Year |
|---|---|
Use of the anticonvulsant carbamazepine in primary and secondary affective illness: clinical and theoretical implications.
Topics: Affective Disorders, Psychotic; Animals; Antidepressive Agents; Antipsychotic Agents; Bipolar Disord | 1982 |
Effect of sodium valproate on mania. The GABA-hypothesis of affective disorders.
Topics: Adolescent; Adult; Affective Disorders, Psychotic; Alcohol Withdrawal Delirium; Bipolar Disorder; Cl | 1980 |
[One of the methods of treatment of affective disorders in patients with alcoholism].
Topics: Adult; Affective Disorders, Psychotic; Alcoholism; beta-Endorphin; Brain; Double-Blind Method; Elect | 1991 |
5 other studies available for gamma-aminobutyric acid and Affective Disorders, Psychotic
| Article | Year |
|---|---|
Orbitofrontal cortex function and structure in depression.
Topics: Affective Disorders, Psychotic; Animals; Depression; Frontal Lobe; gamma-Aminobutyric Acid; Humans; | 2007 |
On a possible role of GABA in mania. Therapeutic efficacy of sodium valproate.
Topics: Affective Disorders, Psychotic; Bipolar Disorder; Double-Blind Method; Drug Evaluation; gamma-Aminob | 1981 |
Possible drug differentiation of the psychoses.
Topics: Affective Disorders, Psychotic; Bipolar Disorder; Diagnosis, Differential; gamma-Aminobutyric Acid; | 1982 |
CSF GABA in normal subjects and patients with depression, schizophrenia, mania, and anorexia nervosa.
Topics: Adolescent; Adult; Affective Disorders, Psychotic; Aged; Anorexia Nervosa; Bipolar Disorder; Depress | 1981 |
Plasma GABA in mood disorders.
Topics: Affective Disorders, Psychotic; gamma-Aminobutyric Acid; Humans; Mood Disorders | 1990 |