gamma-aminobutyric acid has been researched along with Adhesions, Tissue in 3 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Levy, BS | 1 |
| Silverman, A | 1 |
| Samuels, Q | 1 |
| Gikas, H | 1 |
| Nawras, A | 1 |
| Kroin, JS | 1 |
| Buvanendran, A | 1 |
| Cochran, E | 1 |
| Tuman, KJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pregabalin for the Treatment of Abdominal Pain From Adhesions: Placebo Controlled Trial[NCT00310765] | Phase 4 | 18 participants (Actual) | Interventional | 2006-03-31 | Terminated (stopped due to Study was terminated by the sponsor due to low accrual.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Patients were randomized to pregabalin or placebo 75 mg twice a day. Patients were allowed to double the dose on day 3 if adequate pain relief was not obtained. Abdominal pain reduction was measured on a Likert scale. A Likert scale assumes the intensity of pain is linear on a continuum from no pain at level 0 to severe pain at level 10. Patients were required to complete a daily dairy recording pain using the Likert 11-point numeric scale. The primary end point was a positive change in the daily pain diary of 2 points from each patient's baseline at weeks 8 after the completion of the blinded study and at week 12 during the open label portion of the study. After 7 weeks all patients are randomized to study drug pregabalin 150 to 300 mg daily for 4 additional weeks after a one week wash out with no medication. (NCT00310765)
Timeframe: Baseline and week 2 through week 12
| Intervention | units on a scale (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| baseline pain score | week 2 | week 3 | week 4 | week 5 | week 6 | week 7 | week 8 open label with no study medication | week 9 open label | week 10 open label | week 11 open label | week 12 open label | |
| Patients Treated With Placebo | 5.8 | 5.22 | 4.64 | 4.84 | 4.32 | 3.88 | 3.92 | 4.13 | 2.21 | 2.27 | 2.23 | 1.13 |
| Patients Treated With Pregabalin | 6.15 | 2.87 | 1.88 | 3.31 | 2.72 | 2.49 | 2.53 | 2.46 | 2.06 | 1.84 | 1.46 | 1.68 |
Absolute Improvement in Sleep by assessing Mean Daily sleep interference scores as measured weekly starting at baseline and reported weekly through week 12 excluding the first week. This score is an 11 point scale the documents the pain interference in sleep in the preceding 24 hours. 0 is no interference and 10 is pain completely disrupted sleep in the previous 24 hours. During the study patients recorded a daily sleep interference score based on 11 point scale (0-10) with the higher number being the most sleep interference (NCT00310765)
Timeframe: Baseline and week 2 through week 12
| Intervention | units on a scale (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| baseline | week 2 | week 3 | week 4 | week 5 | week 6 | week 7 | week 8 open label no study medication | week 9 open label | week 10 open label | week 11 open label | week 12 open label | |
| Placebo | 4.66 | 3.4 | 3.26 | 3.54 | 3.06 | 2.74 | 3.18 | 3.30 | 1.70 | 1.25 | 1.18 | 0.56 |
| Pregabalin | 3.94 | 2.20 | 1.60 | 1.68 | 1.68 | 1.55 | 1.6 | 1.82 | 1.31 | 1.37 | 1.39 | 1.01 |
1 review available for gamma-aminobutyric acid and Adhesions, Tissue
| Article | Year |
|---|---|
The complex nature of chronic pelvic pain.
Topics: Adult; Amines; Anti-Anxiety Agents; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, | 2007 |
1 trial available for gamma-aminobutyric acid and Adhesions, Tissue
| Article | Year |
|---|---|
Pregabalin for the treatment of abdominal adhesion pain: a randomized, double-blind, placebo-controlled trial.
Topics: Abdomen; Abdominal Pain; Adult; Analgesics; Chronic Pain; Double-Blind Method; Female; gamma-Aminobu | 2012 |
1 other study available for gamma-aminobutyric acid and Adhesions, Tissue
| Article | Year |
|---|---|
Characterization of pain and pharmacologic responses in an animal model of lumbar adhesive arachnoiditis.
Topics: Amines; Analgesics; Analgesics, Opioid; Animals; Arachnoiditis; Behavior, Animal; Cauda Equina; Cycl | 2005 |