gamma-aminobutyric acid has been researched along with Acute Post-Traumatic Stress Disorder in 57 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It has been suggested that the anticonvulsant drug pregabalin may be useful in some anxiety disorders." | 5.19 | Effect of pregabalin augmentation in treatment of patients with combat-related chronic posttraumatic stress disorder: a randomized controlled trial. ( Baniasadi, M; Fayyazi Bordbar, MR; Hosseini, G; Mostafavi Toroghi, H; Rezaei Ardani, A, 2014) |
| "Pregabalin effectively reduced the severity of PTSD symptoms but it was not effective in improving the severity of depression, anxiety, and quality of life." | 5.19 | Effect of pregabalin augmentation in treatment of patients with combat-related chronic posttraumatic stress disorder: a randomized controlled trial. ( Baniasadi, M; Fayyazi Bordbar, MR; Hosseini, G; Mostafavi Toroghi, H; Rezaei Ardani, A, 2014) |
| " The physiological state (body weight and plasma corticosterone concentrations), emotion, cognitive behavior, brain morphology, apoptosis, and balance of gamma-aminobutyric acid (GABA) and glutamate in the hippocampus and prefrontal cortex were observed." | 3.80 | Glutamate and GABA imbalance promotes neuronal apoptosis in hippocampus after stress. ( Chen, C; Gao, J; Li, S; Li, YY; Liu, LM; Liu, Y; Wang, H; Wu, YM; Yang, C, 2014) |
| "In the short term, doses of 100 mg/kg and 300 mg/kg of pregabalin effectively attenuated anxiety-like behaviors." | 3.74 | Brief post-stressor treatment with pregabalin in an animal model for PTSD: short-term anxiolytic effects without long-term anxiogenic effect. ( Cohen, H; Ifergane, G; Kaplan, Z; Matar, MA; Zohar, J, 2008) |
| "MDD and PTSD patients present abnormalities in the HPA axis regulation, such as altered cortisol levels or failure to suppress cortisol release in the dexamethasone suppression test." | 2.72 | The Role of HPA Axis and Allopregnanolone on the Neurobiology of Major Depressive Disorders and PTSD. ( Almeida, FB; Barros, HMT; Pinna, G, 2021) |
| "Posttraumatic stress disorder (PTSD) symptoms may improve significantly with antidepressant medications, however some phenomena often remain refractory to the most commonly used treatments." | 2.70 | Gabapentin in PTSD: a retrospective, clinical series of adjunctive therapy. ( Brodrick, PS; Hamner, MB; Labbate, LA, 2001) |
| "The gabapentin was often first prescribed to facilitate sleep." | 2.70 | Gabapentin in PTSD: a retrospective, clinical series of adjunctive therapy. ( Brodrick, PS; Hamner, MB; Labbate, LA, 2001) |
| "Posttraumatic stress disorder (PTSD) is a trauma and stressor-related disorder that results in complex somatic, cognitive, affective and behavioural effects, after exposure to traumatic event(s)." | 2.58 | Systematic review of in-vivo neuro magnetic resonance spectroscopy for the assessment of posttraumatic stress disorder. ( Mountford, C; Quadrelli, S; Ramadan, S, 2018) |
| "Posttraumatic stress disorder (PTSD) is a chronic and debilitating psychiatric disorder afflicting millions of individuals across the world." | 2.55 | Glutamate dysregulation and glutamatergic therapeutics for PTSD: Evidence from human studies. ( Abdallah, CG; Averill, CL; Averill, LA; Boesl, MA; Krystal, JH; Purohit, P, 2017) |
| "Post-traumatic stress disorder (PTSD) is a debilitating disorder which, after a sufficient delay, may be diagnosed amongst individuals who respond with intense fear, helplessness or horror to traumatic events." | 2.50 | Pharmacological interventions for preventing post-traumatic stress disorder (PTSD). ( Amos, T; Ipser, JC; Stein, DJ, 2014) |
| "The complex aetiology of PTSD, for which experiencing a traumatic event forms a necessary condition, makes it difficult to identify specific genes that substantially contribute to the disorder." | 2.44 | The genetic background to PTSD. ( Boer, F; Broekman, BF; Olff, M, 2007) |
| " In this article, we examine issues related to the long-term use of benzodiazepines, including concerns about the development of therapeutic tolerance, dose escalation, and adverse cognitive effects." | 2.43 | Benzodiazepines in clinical practice: consideration of their long-term use and alternative agents. ( Pollack, MH; Stevens, JC, 2005) |
| "Posttraumatic stress disorder (PTSD) develops after exposure to events that are threatening and/or intensely distressing." | 2.41 | The psychobiology of posttraumatic stress disorder. ( Nutt, DJ, 2000) |
| "Melatonin is an endogenous hormone which modulates sleep-wake cycles." | 1.91 | Melatonin alleviates PTSD-like behaviors and restores serum GABA and cortisol levels in mice. ( Jin, W; Li, W; Sun, Y; Wang, Q; Xu, Z; Yang, J; Yu, L, 2023) |
| "As compared to no-shock controls, PTSD-like mice spent significantly more time freezing and displayed less rearing in a contextual fear test, spent significantly less time in and had fewer entries into open arms in an elevated maze test, and spent significantly less time in and had fewer entries into a light box in a light-dark transition task." | 1.91 | Melatonin alleviates PTSD-like behaviors and restores serum GABA and cortisol levels in mice. ( Jin, W; Li, W; Sun, Y; Wang, Q; Xu, Z; Yang, J; Yu, L, 2023) |
| "Testosterone levels in PTSD patients differed neither from that observed in PTSD resistant nor control groups." | 1.72 | Biomarkers in PTSD-susceptible and resistant veterans with war experience of more than ten years ago: FOCUS ON cortisol, thyroid hormones, testosterone and GABA. ( Boks, MP; Chipeeva, N; de Kloet, ER; Feklicheva, I; Komelkova, M; Korobova, S; Kuznetsova, Y; Mamonova, M; Maslennikova, E; Pashkov, A; Platkovski, P; Sidorenko, O; Tseilikman, O; Tseilikman, V; Vasilenko, T, 2022) |
| "The Clinician Administered PTSD Scale measured hyperarousal symptoms, including sleep disruption." | 1.72 | Regional specificity and clinical correlates of cortical GABA alterations in posttraumatic stress disorder. ( Eric Jensen, J; Olson, EA; Ren, B; Rosso, IM; Silveri, MM, 2022) |
| "In analyses using PTSD diagnosis as a categorical group variable, women with and without a diagnosis of PTSD did not differ in plasma GABA levels (ps > ." | 1.62 | Plasma gamma-aminobutyric acid (GABA) levels and posttraumatic stress disorder symptoms in trauma-exposed women: a preliminary report. ( Anderson, GM; Arditte Hall, KA; DeLane, SE; Lago, TR; Pineles, SL; Rasmusson, AM; Shor, R; Wang, W, 2021) |
| "Patients with PTSD, as well as rodent models of PTSD, demonstrate structural and functional changes in brain regions mediating fear learning, including prefrontal cortex (PFC), amygdala (AMYG), and hippocampus (HC)." | 1.43 | Increased Cortical Gamma-Aminobutyric Acid Precedes Incomplete Extinction of Conditioned Fear and Increased Hippocampal Excitatory Tone in a Mouse Model of Mild Traumatic Brain Injury. ( Charlton, JL; Conti, AC; Galloway, MP; Ghoddoussi, F; Kohler, RJ; Perrine, SA; Schneider, BL, 2016) |
| "This hypothesis was studied in 17 PTSD patients and 17 healthy Controls using classic and emotional Stroop paradigms." | 1.43 | Is plasma GABA level a biomarker of Post-Traumatic Stress Disorder (PTSD) severity? A preliminary study. ( Andruetan, Y; Caillet, L; Canini, F; de Montleau, F; Denis, J; Lefebvre, B; Trousselard, M, 2016) |
| "During baseline, PTSD had lower plasma GABA concentrations than the Controls." | 1.43 | Is plasma GABA level a biomarker of Post-Traumatic Stress Disorder (PTSD) severity? A preliminary study. ( Andruetan, Y; Caillet, L; Canini, F; de Montleau, F; Denis, J; Lefebvre, B; Trousselard, M, 2016) |
| "Intense stress promotes PTSD, which has been associated with exaggerated startle and deficient sensorimotor gating." | 1.42 | Predator Stress-Induced CRF Release Causes Enduring Sensitization of Basolateral Amygdala Norepinephrine Systems that Promote PTSD-Like Startle Abnormalities. ( Bakshi, VP; Baldo, BA; Rajbhandari, AK, 2015) |
| "Thirteen adults with DSM-IV PTSD and 13 matched healthy control subjects underwent single voxel (1) H-MRS at 4 Tesla." | 1.40 | Insula and anterior cingulate GABA levels in posttraumatic stress disorder: preliminary findings using magnetic resonance spectroscopy. ( Crowley, DJ; Jensen, JE; Rauch, SL; Rosso, IM; Silveri, MM; Weiner, MR, 2014) |
| "Insula GABA was significantly lower in PTSD subjects than in controls, and dorsal ACC GABA did not differ significantly between the groups." | 1.40 | Insula and anterior cingulate GABA levels in posttraumatic stress disorder: preliminary findings using magnetic resonance spectroscopy. ( Crowley, DJ; Jensen, JE; Rauch, SL; Rosso, IM; Silveri, MM; Weiner, MR, 2014) |
| "Heavy drinking in PTSD is associated with partially neutralized neurotransmitter imbalance, but also with neuronal injury commonly observed in AUD." | 1.40 | A preliminary examination of cortical neurotransmitter levels associated with heavy drinking in posttraumatic stress disorder. ( Abé, C; Batki, SL; Meyerhoff, DJ; Pennington, DL, 2014) |
| "Although posttraumatic stress disorder (PTSD) is associated with a variety of structural and functional brain changes, the molecular pathophysiological mechanisms underlying these macroscopic alterations are unknown." | 1.40 | Prefrontal GABA and glutathione imbalance in posttraumatic stress disorder: preliminary findings. ( Hasler, G; Michels, L; Mueller-Pfeiffer, C; O'Gorman, RL; Schick, M; Schulte-Vels, T; Zeffiro, T, 2014) |
| "The findings have implications for PTSD treatment approaches." | 1.40 | Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality. ( Metzler, T; Meyerhoff, DJ; Mon, A; Neylan, TC, 2014) |
| "As expected, PTSD+ had higher depressive and anxiety symptom scores and a higher Insomnia Severity Index (ISI) score." | 1.40 | Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality. ( Metzler, T; Meyerhoff, DJ; Mon, A; Neylan, TC, 2014) |
| "Twenty-seven patients with PTSD (PTSD+) and 18 trauma-exposed controls without PTSD (PTSD-), recruited from United States Army reservists, Army National Guard, and mental health clinics." | 1.40 | Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality. ( Metzler, T; Meyerhoff, DJ; Mon, A; Neylan, TC, 2014) |
| "We investigated the effect of a PTSD-like animal model induced by severe stress." | 1.40 | Glutamate and GABA imbalance promotes neuronal apoptosis in hippocampus after stress. ( Chen, C; Gao, J; Li, S; Li, YY; Liu, LM; Liu, Y; Wang, H; Wu, YM; Yang, C, 2014) |
| "However, PTSD-related pathological changes in the hippocampus and prefrontal cortex remain poorly understood." | 1.40 | Glutamate and GABA imbalance promotes neuronal apoptosis in hippocampus after stress. ( Chen, C; Gao, J; Li, S; Li, YY; Liu, LM; Liu, Y; Wang, H; Wu, YM; Yang, C, 2014) |
| "PTSD is associated with reduced GABA in the right anterior insula." | 1.40 | Insula and anterior cingulate GABA levels in posttraumatic stress disorder: preliminary findings using magnetic resonance spectroscopy. ( Crowley, DJ; Jensen, JE; Rauch, SL; Rosso, IM; Silveri, MM; Weiner, MR, 2014) |
| "Posttraumatic stress disorder (PTSD) patients have low cortical concentrations of γ-aminobutyric acid (GABA) and elevated glutamate (Glu) as measured by proton magnetic resonance spectroscopy ((1)H MRS)." | 1.40 | A preliminary examination of cortical neurotransmitter levels associated with heavy drinking in posttraumatic stress disorder. ( Abé, C; Batki, SL; Meyerhoff, DJ; Pennington, DL, 2014) |
| "Major depression is a mental disorder often preceded by exposure to chronic stress or stressful life events." | 1.39 | Social vs. environmental stress models of depression from a behavioural and neurochemical approach. ( Elizalde, N; García-García, AL; Tordera, RM; Venzala, E, 2013) |
| "These results suggest that mild traumatic brain injury predisposes the brain toward heightened fear learning during stressful postinjury events and provides a potential molecular mechanism by which this occurs." | 1.38 | Concussive brain injury enhances fear learning and excitatory processes in the amygdala. ( Buen, F; Fanselow, MS; Giza, CC; Hovda, DA; Poulos, AM; Reger, ML, 2012) |
| "Depression, epilepsy, post traumatic stress disorder (PTSD), and chronic pain exemplify medical conditions that are exacerbated by stress, have low heart rate variability (HRV) and low GABAergic activity, respond to pharmacologic agents that increase activity of the GABA system, and show symptom improvement in response to yoga-based interventions." | 1.38 | Effects of yoga on the autonomic nervous system, gamma-aminobutyric-acid, and allostasis in epilepsy, depression, and post-traumatic stress disorder. ( Brown, RP; Ciraulo, DA; Gerbarg, PL; Saper, RB; Streeter, CC, 2012) |
| " Nine patients meeting Diagnostic and Statistical Manual, fourth edition criteria for PTSD who were on stable doses of antidepressants were treated open label with flexibly dosed pregabalin for 6 weeks." | 1.35 | Pregabalin augmentation of antidepressants in patients with accident-related posttraumatic stress disorder: an open label pilot study. ( Han, C; Marks, DM; Masand, PS; Pae, CU; Patkar, AA, 2009) |
| "Patients were assessed for PTSD and major depressive disorder at 6-week and 1-year follow-ups." | 1.33 | Relationship between posttrauma GABA plasma levels and PTSD at 1-year follow-up. ( Boss, V; Brunet, A; Devos, P; Ducrocq, F; Fontaine, M; Goudemand, M; Laffargue, P; Thomas, P; Vaiva, G, 2006) |
| "The mean GABA level (nmol/mL) in the PTSD group (n = 55; M =." | 1.32 | Low posttrauma GABA plasma levels as a predictive factor in the development of acute posttraumatic stress disorder. ( Boss, V; Brunet, A; Cottencin, O; Devos, P; Ducrocq, F; Fontaine, M; Goudemand, M; Laffargue, P; Rascle, C; Thomas, P; Vaiva, G, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (7.02) | 18.2507 |
| 2000's | 19 (33.33) | 29.6817 |
| 2010's | 25 (43.86) | 24.3611 |
| 2020's | 9 (15.79) | 2.80 |
| Authors | Studies |
|---|---|
| Rosso, IM | 2 |
| Silveri, MM | 2 |
| Olson, EA | 1 |
| Eric Jensen, J | 1 |
| Ren, B | 1 |
| Fernández de Sevilla, ME | 1 |
| Pignatelli, J | 1 |
| Zegarra-Valdivia, JA | 1 |
| Mendez, P | 1 |
| Nuñez, A | 1 |
| Torres Alemán, I | 1 |
| Feklicheva, I | 1 |
| Boks, MP | 2 |
| de Kloet, ER | 1 |
| Chipeeva, N | 1 |
| Maslennikova, E | 1 |
| Pashkov, A | 1 |
| Korobova, S | 1 |
| Komelkova, M | 1 |
| Kuznetsova, Y | 1 |
| Platkovski, P | 1 |
| Mamonova, M | 1 |
| Sidorenko, O | 1 |
| Vasilenko, T | 1 |
| Tseilikman, O | 1 |
| Tseilikman, V | 1 |
| Xu, Z | 1 |
| Li, W | 1 |
| Sun, Y | 1 |
| Jin, W | 1 |
| Yu, L | 1 |
| Yang, J | 1 |
| Wang, Q | 1 |
| Borgonetti, V | 1 |
| Cruz, B | 1 |
| Vozella, V | 1 |
| Khom, S | 1 |
| Steinman, MQ | 1 |
| Bullard, R | 1 |
| D'Ambrosio, S | 1 |
| Oleata, CS | 1 |
| Vlkolinsky, R | 1 |
| Bajo, M | 1 |
| Zorrilla, EP | 1 |
| Kirson, D | 1 |
| Roberto, M | 1 |
| Richards, A | 1 |
| Kanady, JC | 1 |
| Neylan, TC | 2 |
| Shang, C | 1 |
| Guo, Y | 1 |
| Yao, JQ | 1 |
| Fang, XX | 1 |
| Sun, LJ | 1 |
| Jiang, XY | 1 |
| Ding, ZC | 1 |
| Ran, YH | 1 |
| Wang, HL | 1 |
| Zhang, LM | 1 |
| Li, YF | 1 |
| Arditte Hall, KA | 1 |
| DeLane, SE | 1 |
| Anderson, GM | 1 |
| Lago, TR | 1 |
| Shor, R | 1 |
| Wang, W | 1 |
| Rasmusson, AM | 1 |
| Pineles, SL | 1 |
| Almeida, FB | 1 |
| Pinna, G | 1 |
| Barros, HMT | 1 |
| Quadrelli, S | 1 |
| Mountford, C | 1 |
| Ramadan, S | 1 |
| Konen, C | 1 |
| Niederst, E | 1 |
| Gravitz, L | 1 |
| Signorelli, MS | 1 |
| Costanzo, MC | 1 |
| Cinconze, M | 1 |
| Concerto, C | 1 |
| Weiner, MR | 1 |
| Crowley, DJ | 1 |
| Rauch, SL | 1 |
| Jensen, JE | 1 |
| Sarro, EC | 1 |
| Sullivan, RM | 1 |
| Barr, G | 1 |
| Gao, J | 1 |
| Wang, H | 1 |
| Liu, Y | 1 |
| Li, YY | 1 |
| Chen, C | 1 |
| Liu, LM | 1 |
| Wu, YM | 1 |
| Li, S | 1 |
| Yang, C | 1 |
| Meyerhoff, DJ | 2 |
| Mon, A | 1 |
| Metzler, T | 1 |
| Amos, T | 1 |
| Stein, DJ | 2 |
| Ipser, JC | 1 |
| Baniasadi, M | 1 |
| Hosseini, G | 1 |
| Fayyazi Bordbar, MR | 1 |
| Rezaei Ardani, A | 1 |
| Mostafavi Toroghi, H | 1 |
| Pennington, DL | 1 |
| Abé, C | 1 |
| Batki, SL | 1 |
| Michels, L | 1 |
| Schulte-Vels, T | 1 |
| Schick, M | 1 |
| O'Gorman, RL | 1 |
| Zeffiro, T | 1 |
| Hasler, G | 1 |
| Mueller-Pfeiffer, C | 1 |
| Rajbhandari, AK | 1 |
| Baldo, BA | 1 |
| Bakshi, VP | 1 |
| Schneider, BL | 1 |
| Ghoddoussi, F | 1 |
| Charlton, JL | 1 |
| Kohler, RJ | 1 |
| Galloway, MP | 2 |
| Perrine, SA | 2 |
| Conti, AC | 1 |
| Trousselard, M | 1 |
| Lefebvre, B | 1 |
| Caillet, L | 1 |
| Andruetan, Y | 1 |
| de Montleau, F | 1 |
| Denis, J | 1 |
| Canini, F | 1 |
| Schür, RR | 1 |
| Geuze, E | 1 |
| Prinsen, HC | 1 |
| Verhoeven-Duif, NM | 1 |
| Joëls, M | 1 |
| Kahn, RS | 1 |
| Vermetten, E | 1 |
| Vinkers, CH | 1 |
| Averill, LA | 1 |
| Purohit, P | 1 |
| Averill, CL | 1 |
| Boesl, MA | 1 |
| Krystal, JH | 1 |
| Abdallah, CG | 1 |
| Zohar, J | 2 |
| Matar, MA | 1 |
| Ifergane, G | 1 |
| Kaplan, Z | 1 |
| Cohen, H | 1 |
| Ooba, S | 1 |
| Hasuo, H | 1 |
| Shigemori, M | 1 |
| Akasu, T | 1 |
| Strawn, JR | 1 |
| Dowling, BP | 1 |
| Geracioti, TD | 1 |
| Pae, CU | 1 |
| Marks, DM | 1 |
| Han, C | 1 |
| Masand, PS | 1 |
| Patkar, AA | 1 |
| Knox, D | 1 |
| George, SA | 1 |
| Liberzon, I | 1 |
| Paslakis, G | 1 |
| Gilles, M | 1 |
| Deuschle, M | 1 |
| Reger, ML | 1 |
| Poulos, AM | 1 |
| Buen, F | 1 |
| Giza, CC | 1 |
| Hovda, DA | 1 |
| Fanselow, MS | 1 |
| Streeter, CC | 1 |
| Gerbarg, PL | 1 |
| Saper, RB | 1 |
| Ciraulo, DA | 1 |
| Brown, RP | 1 |
| Bandelow, B | 1 |
| Sher, L | 1 |
| Bunevicius, R | 1 |
| Hollander, E | 1 |
| Kasper, S | 1 |
| Möller, HJ | 1 |
| Searcy, CP | 1 |
| Bobadilla, L | 1 |
| Gordon, WA | 1 |
| Jacques, S | 1 |
| Elliott, L | 1 |
| Venzala, E | 1 |
| García-García, AL | 1 |
| Elizalde, N | 1 |
| Tordera, RM | 1 |
| Huang, R | 1 |
| Li, Z | 1 |
| Chen, H | 1 |
| Huang, Y | 1 |
| Ding, L | 1 |
| Berigan, TR | 1 |
| Malek-Ahmadi, P | 1 |
| Pigott, TA | 1 |
| Vaiva, G | 2 |
| Thomas, P | 2 |
| Ducrocq, F | 2 |
| Fontaine, M | 2 |
| Boss, V | 2 |
| Devos, P | 2 |
| Rascle, C | 1 |
| Cottencin, O | 1 |
| Brunet, A | 2 |
| Laffargue, P | 2 |
| Goudemand, M | 2 |
| Harvey, BH | 1 |
| Oosthuizen, F | 1 |
| Brand, L | 1 |
| Wegener, G | 1 |
| Stevens, JC | 1 |
| Pollack, MH | 1 |
| Mataix-Cols, D | 1 |
| van den Heuvel, OA | 1 |
| Schwartz, TL | 1 |
| Nihalani, N | 1 |
| Broekman, BF | 1 |
| Olff, M | 1 |
| Boer, F | 1 |
| Stein, MB | 1 |
| Kerridge, C | 1 |
| Dimsdale, JE | 1 |
| Hoyt, DB | 1 |
| Macleod, AD | 1 |
| Markowitz, JS | 1 |
| Finkenbine, R | 1 |
| Myrick, H | 1 |
| King, L | 1 |
| Carson, WH | 1 |
| Vaquerizo, J | 1 |
| Romero-Rodríguez, JC | 1 |
| González-Roncero, A | 1 |
| Gómez-Marcos, A | 1 |
| Donnelly, CL | 1 |
| Amaya-Jackson, L | 1 |
| March, JS | 1 |
| Brannon, N | 1 |
| Labbate, L | 1 |
| Huber, M | 1 |
| Nutt, DJ | 1 |
| Hageman, I | 1 |
| Andersen, HS | 1 |
| Jørgensen, MB | 1 |
| Hamner, MB | 1 |
| Brodrick, PS | 1 |
| Labbate, LA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD[NCT02884908] | Phase 3 | 252 participants (Anticipated) | Interventional | 2016-09-30 | Active, not recruiting | ||
| Application of Vagal Stimulation by Cold Face Mask in Exposure and Response Prevention for Obsessive Compulsive Disorder[NCT02196090] | 10 participants (Anticipated) | Interventional | 2014-07-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
15 reviews available for gamma-aminobutyric acid and Acute Post-Traumatic Stress Disorder
| Article | Year |
|---|---|
Sleep disturbance in PTSD and other anxiety-related disorders: an updated review of clinical features, physiological characteristics, and psychological and neurobiological mechanisms.
Topics: Anxiety Disorders; Brain; Dopamine; gamma-Aminobutyric Acid; Humans; Orexins; Sleep; Sleep Wake Diso | 2020 |
The Role of HPA Axis and Allopregnanolone on the Neurobiology of Major Depressive Disorders and PTSD.
Topics: Adaptation, Physiological; Animals; Antidepressive Agents; Chronic Disease; Corticosterone; Depressi | 2021 |
Systematic review of in-vivo neuro magnetic resonance spectroscopy for the assessment of posttraumatic stress disorder.
Topics: Aspartic Acid; Atrophy; Brain; Creatine; Female; gamma-Aminobutyric Acid; Gyrus Cinguli; Hippocampus | 2018 |
Pharmacological interventions for preventing post-traumatic stress disorder (PTSD).
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Aged; Amines; Anti-Anxiety Agents; Anti-Inflammatory | 2014 |
Glutamate dysregulation and glutamatergic therapeutics for PTSD: Evidence from human studies.
Topics: Brain; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Receptors, Glutamate; Stress Disorders, Post- | 2017 |
Pharmacological prevention of combat-related PTSD: a literature review.
Topics: Catecholamines; GABA Agents; gamma-Aminobutyric Acid; Glucocorticoids; Humans; Hypothalamo-Hypophyse | 2012 |
[Pharmacological intervention of conditioned fear and its extinction].
Topics: Animals; Anxiety Disorders; Cannabinoids; Conditioning, Psychological; Extinction, Psychological; Fe | 2012 |
Anxiety disorders in women.
Topics: Agoraphobia; Anti-Anxiety Agents; Anxiety Disorders; Comorbidity; Female; gamma-Aminobutyric Acid; H | 2003 |
Benzodiazepines in clinical practice: consideration of their long-term use and alternative agents.
Topics: Anti-Anxiety Agents; Anticonvulsants; Antipsychotic Agents; Anxiety Disorders; Benzodiazepines; Cogn | 2005 |
Common and distinct neural correlates of obsessive-compulsive and related disorders.
Topics: Anxiety Disorders; Frontal Lobe; gamma-Aminobutyric Acid; Humans; Limbic System; Nerve Net; Obsessiv | 2006 |
Tiagabine in anxiety disorders.
Topics: Anxiety Disorders; Female; GABA Agonists; gamma-Aminobutyric Acid; Humans; Male; Nipecotic Acids; Ra | 2006 |
The genetic background to PTSD.
Topics: Apolipoproteins; Brain; Brain-Derived Neurotrophic Factor; Dopamine; gamma-Aminobutyric Acid; Humans | 2007 |
Psychopharmacology of pediatric posttraumatic stress disorder.
Topics: Adolescent; Catecholamines; Child; Comorbidity; gamma-Aminobutyric Acid; Humans; Neurosecretory Syst | 1999 |
The psychobiology of posttraumatic stress disorder.
Topics: Brain; gamma-Aminobutyric Acid; Glutamates; Humans; Hypothalamo-Hypophyseal System; Life Change Even | 2000 |
Post-traumatic stress disorder: a review of psychobiology and pharmacotherapy.
Topics: gamma-Aminobutyric Acid; Glutamic Acid; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Nore | 2001 |
4 trials available for gamma-aminobutyric acid and Acute Post-Traumatic Stress Disorder
| Article | Year |
|---|---|
Effect of pregabalin augmentation in treatment of patients with combat-related chronic posttraumatic stress disorder: a randomized controlled trial.
Topics: Adult; Anticonvulsants; Antidepressive Agents; Anxiety; Combat Disorders; Depression; Double-Blind M | 2014 |
Pharmacotherapy to prevent PTSD: Results from a randomized controlled proof-of-concept trial in physically injured patients.
Topics: Adolescent; Adult; Amines; Anti-Anxiety Agents; California; Cyclohexanecarboxylic Acids; Female; Gab | 2007 |
Gabapentin treatment for posttraumatic stress disorder.
Topics: Acetates; Amines; Anti-Anxiety Agents; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric A | 2000 |
Gabapentin in PTSD: a retrospective, clinical series of adjunctive therapy.
Topics: Acetates; Adult; Aged; Amines; Anti-Anxiety Agents; Cyclohexanecarboxylic Acids; Gabapentin; gamma-A | 2001 |
38 other studies available for gamma-aminobutyric acid and Acute Post-Traumatic Stress Disorder
| Article | Year |
|---|---|
Regional specificity and clinical correlates of cortical GABA alterations in posttraumatic stress disorder.
Topics: Adult; Brain; Creatine; Dissociative Disorders; gamma-Aminobutyric Acid; Humans; Magnetic Resonance | 2022 |
Insulin-like growth factor I mitigates post-traumatic stress by inhibiting AMP-kinase in orexin neurons.
Topics: Adenosine Monophosphate; Adenylate Kinase; AMP-Activated Protein Kinases; Animals; gamma-Aminobutyri | 2022 |
Biomarkers in PTSD-susceptible and resistant veterans with war experience of more than ten years ago: FOCUS ON cortisol, thyroid hormones, testosterone and GABA.
Topics: Biomarkers; Disease Susceptibility; gamma-Aminobutyric Acid; Humans; Hydrocortisone; Stress Disorder | 2022 |
Melatonin alleviates PTSD-like behaviors and restores serum GABA and cortisol levels in mice.
Topics: Animals; gamma-Aminobutyric Acid; Hydrocortisone; Melatonin; Mice; Receptors, Melatonin; Stress Diso | 2023 |
IL-18 Signaling in the Rat Central Amygdala Is Disrupted in a Comorbid Model of Post-Traumatic Stress and Alcohol Use Disorder.
Topics: Alcohol Drinking; Alcoholism; Animals; Central Amygdaloid Nucleus; Ethanol; Female; gamma-Aminobutyr | 2023 |
Rapid anti-PTSD-like activity of the TSPO agonist YL-IPA08: Emphasis on brain GABA, neurosteroids and HPA axis function.
Topics: Animals; Behavior, Animal; Carrier Proteins; Corticosterone; Disease Models, Animal; gamma-Aminobuty | 2020 |
Plasma gamma-aminobutyric acid (GABA) levels and posttraumatic stress disorder symptoms in trauma-exposed women: a preliminary report.
Topics: Adult; Chromatography, Liquid; Female; Follicular Phase; gamma-Aminobutyric Acid; Humans; Luteal Pha | 2021 |
Special Issue on Disease: New Advances in Psychiatry.
Topics: Animals; Brain; Cerebellum; Depression, Postpartum; Depressive Disorder; Female; gamma-Aminobutyric | 2019 |
The forgotten part of memory.
Topics: Alzheimer Disease; Animals; Anxiety; Brain; Cerebral Cortex; Dopamine; Dopaminergic Neurons; Drosoph | 2019 |
What kind of diagnosis in a case of mobbing: post-traumatic stress disorder or adjustment disorder?
Topics: Adjustment Disorders; Alprazolam; Anti-Anxiety Agents; Crowding; Diagnosis, Differential; Drug Thera | 2013 |
Insula and anterior cingulate GABA levels in posttraumatic stress disorder: preliminary findings using magnetic resonance spectroscopy.
Topics: Adolescent; Adult; Brain; Brain Mapping; Female; gamma-Aminobutyric Acid; Humans; Magnetic Resonance | 2014 |
Unpredictable neonatal stress enhances adult anxiety and alters amygdala gene expression related to serotonin and GABA.
Topics: Amygdala; Animals; Animals, Newborn; Anxiety; Anxiety Disorders; Conditioning, Classical; Electrosho | 2014 |
Glutamate and GABA imbalance promotes neuronal apoptosis in hippocampus after stress.
Topics: Animals; Anxiety; Apoptosis; Behavior, Animal; Body Weight; Dexamethasone; Emotions; Freezing Reacti | 2014 |
Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality.
Topics: Arousal; Aspartic Acid; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli; Huma | 2014 |
A preliminary examination of cortical neurotransmitter levels associated with heavy drinking in posttraumatic stress disorder.
Topics: Adult; Aged; Alcoholism; Aspartic Acid; Cerebral Cortex; Choline; Comorbidity; Creatine; gamma-Amino | 2014 |
Prefrontal GABA and glutathione imbalance in posttraumatic stress disorder: preliminary findings.
Topics: Adult; Female; gamma-Aminobutyric Acid; Glutathione; Gyrus Cinguli; Humans; Magnetic Resonance Spect | 2014 |
Predator Stress-Induced CRF Release Causes Enduring Sensitization of Basolateral Amygdala Norepinephrine Systems that Promote PTSD-Like Startle Abnormalities.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Basolateral Nuclear Complex; Corticotropin-Rele | 2015 |
Increased Cortical Gamma-Aminobutyric Acid Precedes Incomplete Extinction of Conditioned Fear and Increased Hippocampal Excitatory Tone in a Mouse Model of Mild Traumatic Brain Injury.
Topics: Animals; Behavior, Animal; Brain Concussion; Conditioning, Classical; Extinction, Psychological; Fea | 2016 |
Is plasma GABA level a biomarker of Post-Traumatic Stress Disorder (PTSD) severity? A preliminary study.
Topics: Adult; Biomarkers; Case-Control Studies; Emotions; Female; gamma-Aminobutyric Acid; Humans; Male; Mi | 2016 |
Development of psychopathology in deployed armed forces in relation to plasma GABA levels.
Topics: Adult; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Humans; Male; Military Personnel | 2016 |
Brief post-stressor treatment with pregabalin in an animal model for PTSD: short-term anxiolytic effects without long-term anxiogenic effect.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Anticonvulsants; Anxiety; Behavior, Animal; Cue | 2008 |
Diazepam attenuates the post-traumatic hyperactivity of excitatory synapses in rat hippocampal CA1 neurons.
Topics: Animals; Blood Gas Analysis; Diazepam; Electrophysiology; Excitatory Postsynaptic Potentials; gamma- | 2008 |
Pregabalin treatment of posttraumatic stress disorder.
Topics: Adolescent; Child; Child Abuse, Sexual; Female; gamma-Aminobutyric Acid; Humans; Middle Aged; Pregab | 2008 |
Pregabalin augmentation of antidepressants in patients with accident-related posttraumatic stress disorder: an open label pilot study.
Topics: Accidents; Adult; Anti-Anxiety Agents; Antidepressive Agents; Drug Therapy, Combination; Female; gam | 2009 |
Single prolonged stress decreases glutamate, glutamine, and creatine concentrations in the rat medial prefrontal cortex.
Topics: Amygdala; Animals; Aspartic Acid; Creatine; Energy Metabolism; gamma-Aminobutyric Acid; Glutamic Aci | 2010 |
Pregabalin in the treatment of posttraumatic stress disorder: a case report.
Topics: Afghanistan; Anticonvulsants; Antidepressive Agents; Anxiety; Depressive Disorder; gamma-Aminobutyri | 2011 |
Concussive brain injury enhances fear learning and excitatory processes in the amygdala.
Topics: Affective Symptoms; Amygdala; Animals; Behavior, Animal; Brain Concussion; Conditioning, Psychologic | 2012 |
Effects of yoga on the autonomic nervous system, gamma-aminobutyric-acid, and allostasis in epilepsy, depression, and post-traumatic stress disorder.
Topics: Allostasis; Anxiety Disorders; Autonomic Nervous System; Chronic Pain; Depression; Electric Stimulat | 2012 |
Guidelines for the pharmacological treatment of anxiety disorders, obsessive-compulsive disorder and posttraumatic stress disorder in primary care.
Topics: Antidepressive Agents, Tricyclic; Antipsychotic Agents; Anxiety Disorders; Benzodiazepines; Dose-Res | 2012 |
Social vs. environmental stress models of depression from a behavioural and neurochemical approach.
Topics: Animals; Anxiety; Behavior, Animal; Brain Stem; Depression; Disease Models, Animal; Dopamine; gamma- | 2013 |
Gabapentin and PTSD.
Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Fructose; Gabapentin; gamma-Aminobut | 2002 |
Gabapentin and posttraumatic stress disorder.
Topics: Acetates; Adult; Amines; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Cyclohexanec | 2003 |
Low posttrauma GABA plasma levels as a predictive factor in the development of acute posttraumatic stress disorder.
Topics: Acute Disease; Adult; Biomarkers; Case-Control Studies; Cohort Studies; Female; gamma-Aminobutyric A | 2004 |
Stress-restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus.
Topics: Animals; Chromatography, High Pressure Liquid; Corticosterone; Electrochemistry; Enzyme Inhibitors; | 2004 |
Relationship between posttrauma GABA plasma levels and PTSD at 1-year follow-up.
Topics: Accidents, Traffic; Adolescent; Adult; Aged; Biomarkers; Cohort Studies; Depressive Disorder, Major; | 2006 |
Vigabatrin and posttraumatic stress disorder.
Topics: Anticonvulsants; Arousal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; ga | 1996 |
Gabapentin abuse in a cocaine user: implications for treatment?
Topics: Acetates; Adult; Amines; Anticonvulsants; Crack Cocaine; Cyclohexanecarboxylic Acids; Female; Gabape | 1997 |
[Partial complex status epilepticus: diagnostic difficulties].
Topics: Anticonvulsants; Child; Crime; Diagnosis, Differential; Drug Therapy, Combination; Electroencephalog | 1998 |