gamma-aminobutyric acid has been researched along with Acute Pain in 20 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Acute Pain: Intensely discomforting, distressful, or agonizing sensation associated with trauma or disease, with well-defined location, character, and timing.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the present study was to investigate the effect of perioperative administration of pregabalin on postoperative acute and chronic pain and analgesic requirements." | 9.16 | Perioperative pregabalin for acute and chronic pain after abdominal hysterectomy or myomectomy: a randomised controlled trial. ( Fassoulaki, A; Melemeni, A; Paraskeva, A; Tsaroucha, A, 2012) |
| "Pregabalin in the doses given decreased morphine requirements for the first 48 h postoperatively, but neither altered the analgesic requirements beyond 48 h nor had any effect on acute, late or chronic pain." | 9.16 | Perioperative pregabalin for acute and chronic pain after abdominal hysterectomy or myomectomy: a randomised controlled trial. ( Fassoulaki, A; Melemeni, A; Paraskeva, A; Tsaroucha, A, 2012) |
| " Gabapentin was used as an adjunct for the management of acute pain in approximately half of enhanced recovery programs." | 8.95 | Gabapentin can decrease acute pain and morphine consumption in spinal surgery patients: A meta-analysis of randomized controlled trials. ( Li, C; Peng, C; Qu, J; Wu, D, 2017) |
| " Further studies should determine the optimal dose and whether pregabalin is superior to gabapentin in controlling acute pain after spine surgery." | 8.95 | A meta-analysis of the preoperative use of gabapentinoids for the treatment of acute postoperative pain following spinal surgery. ( Liu, B; Liu, R; Wang, L, 2017) |
| "Pregabalin produced a marked antinociceptive effect in rat models of facial inflammatory pain as well as in facial neuropathic and cancer pain models, suggesting that it may represent an important agent for the clinical control of orofacial pain." | 7.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| "To assess the analgesic effect of pregabalin in orofacial models of acute inflammatory pain and of persistent pain associated with nerve injury and cancer, and so determine its effectiveness in controlling orofacial pains having different underlying mechanisms." | 7.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| "Orofacial capsaicin and formalin tests were employed in male Wistar rats to assess the influence of pregabalin (or vehicle) pretreatment in acute pain models, and the results from these experiments were analyzed by one-way analysis of variance (ANOVA) followed by Newman Keuls post-hoc test." | 7.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| "The aim of the present study was to investigate the possible antinociceptive effects of systemic administration of tramadol and gabapentin either alone or in combination on acute pain models in mice." | 7.78 | The antinociceptive effects of systemic administration of tramadol, gabapentin and their combination on mice model of acute pain. ( Alaçam, B; Aydin, ON; Ek, RO; Şen, S; Temoçin, S; Uğur, B, 2012) |
| "Pregabalin revealed a comparative antinociceptive effect as similar to tramadol in acute model of pain, but interaction between these two drugs depends highly on their proportion in the combination." | 7.78 | Pregabalin antinociception and its interaction with tramadol in acute model of pain. ( Keyhanfar, F; Meymandi, MS, 2012) |
| "The aim of present study was to investigate the antinociceptive effect of pregabalin and tramadol either alone and or in combination on acute model of pain." | 7.78 | Pregabalin antinociception and its interaction with tramadol in acute model of pain. ( Keyhanfar, F; Meymandi, MS, 2012) |
| "Gabapentin was used as an adjunct for the management of acute pain in approximately half of enhanced recovery programs." | 6.55 | Gabapentin can decrease acute pain and morphine consumption in spinal surgery patients: A meta-analysis of randomized controlled trials. ( Li, C; Peng, C; Qu, J; Wu, D, 2017) |
| "Gabapentin was associated with reduced pain scores at 12 hours and 24 hours, corresponding to a reduction of 11." | 6.55 | Gabapentin can decrease acute pain and morphine consumption in spinal surgery patients: A meta-analysis of randomized controlled trials. ( Li, C; Peng, C; Qu, J; Wu, D, 2017) |
| "Gabapentin was efficacious in the reduction of postoperative pain, total morphine consumption, and morphine-related complications following spine surgery." | 6.55 | Gabapentin can decrease acute pain and morphine consumption in spinal surgery patients: A meta-analysis of randomized controlled trials. ( Li, C; Peng, C; Qu, J; Wu, D, 2017) |
| "Gabapentinoids were associated with reduced pain scores at 6, 12, 24, and 48 hours." | 6.55 | A meta-analysis of the preoperative use of gabapentinoids for the treatment of acute postoperative pain following spinal surgery. ( Liu, B; Liu, R; Wang, L, 2017) |
| "It is a novel drug used for the treatment of postoperative pain with antihyperalgesic properties and a unique mechanism of action." | 6.50 | Gabapentin in acute postoperative pain management. ( Challa, CK; Chang, CY; Eloy, JD; Shah, J, 2014) |
| "When gabapentin and tramadol were used in combination, gabapentin had no additive antinociceptive effect except for 300 mg/kg in tail-flick and hot-plate tests." | 5.38 | The antinociceptive effects of systemic administration of tramadol, gabapentin and their combination on mice model of acute pain. ( Alaçam, B; Aydin, ON; Ek, RO; Şen, S; Temoçin, S; Uğur, B, 2012) |
| "Paclitaxel can cause an acute pain syndrome (P-APS), considered to be an acute form of neuropathy and chronic chemotherapy-induced peripheral neuropathy (CIPN)." | 5.22 | Can pregabalin prevent paclitaxel-associated neuropathy?--An ACCRU pilot trial. ( Atherton, PJ; Lafky, J; Loprinzi, CL; Pachman, DR; Ruddy, KJ; Seisler, D; Shinde, SS; Soori, G, 2016) |
| "Acute pain after open abdominal hysterectomy limits the function of patients in the postoperative period, but data regarding the analgesic efficacy of a low dose of pregabalin (75 or 150 mg) have been conflicting." | 5.19 | A randomized placebo-controlled trial of two doses of pregabalin for postoperative analgesia in patients undergoing abdominal hysterectomy. ( Andreou, P; George, RB; Habib, AS; McKeen, DM, 2014) |
| "Pregabalin in the doses given decreased morphine requirements for the first 48 h postoperatively, but neither altered the analgesic requirements beyond 48 h nor had any effect on acute, late or chronic pain." | 5.16 | Perioperative pregabalin for acute and chronic pain after abdominal hysterectomy or myomectomy: a randomised controlled trial. ( Fassoulaki, A; Melemeni, A; Paraskeva, A; Tsaroucha, A, 2012) |
| "The aim of the present study was to investigate the effect of perioperative administration of pregabalin on postoperative acute and chronic pain and analgesic requirements." | 5.16 | Perioperative pregabalin for acute and chronic pain after abdominal hysterectomy or myomectomy: a randomised controlled trial. ( Fassoulaki, A; Melemeni, A; Paraskeva, A; Tsaroucha, A, 2012) |
| " Gabapentin was used as an adjunct for the management of acute pain in approximately half of enhanced recovery programs." | 4.95 | Gabapentin can decrease acute pain and morphine consumption in spinal surgery patients: A meta-analysis of randomized controlled trials. ( Li, C; Peng, C; Qu, J; Wu, D, 2017) |
| " Further studies should determine the optimal dose and whether pregabalin is superior to gabapentin in controlling acute pain after spine surgery." | 4.95 | A meta-analysis of the preoperative use of gabapentinoids for the treatment of acute postoperative pain following spinal surgery. ( Liu, B; Liu, R; Wang, L, 2017) |
| "Orofacial capsaicin and formalin tests were employed in male Wistar rats to assess the influence of pregabalin (or vehicle) pretreatment in acute pain models, and the results from these experiments were analyzed by one-way analysis of variance (ANOVA) followed by Newman Keuls post-hoc test." | 3.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| "To assess the analgesic effect of pregabalin in orofacial models of acute inflammatory pain and of persistent pain associated with nerve injury and cancer, and so determine its effectiveness in controlling orofacial pains having different underlying mechanisms." | 3.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| "Pregabalin produced a marked antinociceptive effect in rat models of facial inflammatory pain as well as in facial neuropathic and cancer pain models, suggesting that it may represent an important agent for the clinical control of orofacial pain." | 3.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| "The aim of present study was to investigate the antinociceptive effect of pregabalin and tramadol either alone and or in combination on acute model of pain." | 3.78 | Pregabalin antinociception and its interaction with tramadol in acute model of pain. ( Keyhanfar, F; Meymandi, MS, 2012) |
| "Pregabalin revealed a comparative antinociceptive effect as similar to tramadol in acute model of pain, but interaction between these two drugs depends highly on their proportion in the combination." | 3.78 | Pregabalin antinociception and its interaction with tramadol in acute model of pain. ( Keyhanfar, F; Meymandi, MS, 2012) |
| "The aim of the present study was to investigate the possible antinociceptive effects of systemic administration of tramadol and gabapentin either alone or in combination on acute pain models in mice." | 3.78 | The antinociceptive effects of systemic administration of tramadol, gabapentin and their combination on mice model of acute pain. ( Alaçam, B; Aydin, ON; Ek, RO; Şen, S; Temoçin, S; Uğur, B, 2012) |
| "Trials of acute pain are complicated by the need to obtain consent, to randomize participants expeditiously while optimally treating pain." | 2.82 | Addressing challenges of clinical trials in acute pain: The Pain Management of Vaso-occlusive Crisis in Children and Young Adults with Sickle Cell Disease Study. ( Anghelescu, DL; Cancio, MI; Christensen, R; Faughnan, LG; Hankins, JS; James, DM; Kang, G; Nottage, KA; Richardson, J; Smeltzer, M; Wang, WC, 2016) |
| "Paclitaxel can cause an acute pain syndrome (P-APS), considered to be an acute form of neuropathy and chronic chemotherapy-induced peripheral neuropathy (CIPN)." | 2.82 | Can pregabalin prevent paclitaxel-associated neuropathy?--An ACCRU pilot trial. ( Atherton, PJ; Lafky, J; Loprinzi, CL; Pachman, DR; Ruddy, KJ; Seisler, D; Shinde, SS; Soori, G, 2016) |
| "Postoperative pain was managed using patient-controlled analgesia with morphine." | 2.79 | A randomized placebo-controlled trial of two doses of pregabalin for postoperative analgesia in patients undergoing abdominal hysterectomy. ( Andreou, P; George, RB; Habib, AS; McKeen, DM, 2014) |
| "Gabapentinoids were associated with reduced pain scores at 6, 12, 24, and 48 hours." | 2.55 | A meta-analysis of the preoperative use of gabapentinoids for the treatment of acute postoperative pain following spinal surgery. ( Liu, B; Liu, R; Wang, L, 2017) |
| "Gabapentin was efficacious in the reduction of postoperative pain, total morphine consumption, and morphine-related complications following spine surgery." | 2.55 | Gabapentin can decrease acute pain and morphine consumption in spinal surgery patients: A meta-analysis of randomized controlled trials. ( Li, C; Peng, C; Qu, J; Wu, D, 2017) |
| "Gabapentin was associated with reduced pain scores at 12 hours and 24 hours, corresponding to a reduction of 11." | 2.55 | Gabapentin can decrease acute pain and morphine consumption in spinal surgery patients: A meta-analysis of randomized controlled trials. ( Li, C; Peng, C; Qu, J; Wu, D, 2017) |
| "Gabapentin was used as an adjunct for the management of acute pain in approximately half of enhanced recovery programs." | 2.55 | Gabapentin can decrease acute pain and morphine consumption in spinal surgery patients: A meta-analysis of randomized controlled trials. ( Li, C; Peng, C; Qu, J; Wu, D, 2017) |
| " There were no significant differences in acute pain outcomes with pregabalin 100-300 mg between single preoperative dosing regimens and those including additional doses repeated after surgery." | 2.52 | Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis. ( Habib, AS; Mishriky, BM; Waldron, NH, 2015) |
| "It is a novel drug used for the treatment of postoperative pain with antihyperalgesic properties and a unique mechanism of action." | 2.50 | Gabapentin in acute postoperative pain management. ( Challa, CK; Chang, CY; Eloy, JD; Shah, J, 2014) |
| "Recent awareness that chronic pain may occur after childbirth has prompted clinicians and researchers to investigate this topic." | 2.49 | Chronic pain after childbirth. ( Bollag, L; Landau, R; Ortner, C, 2013) |
| "Linear regression analysis was used to evaluate the dose-response relationships between logarithms of drug doses and their resultant maximum possible antinociceptive effects in the mouse hot-plate test." | 1.38 | Synergistic interaction of pregabalin with the synthetic cannabinoid WIN 55,212-2 mesylate in the hot-plate test in mice: an isobolographic analysis. ( Florek-Łuszczki, M; Luszczki, JJ, 2012) |
| "When gabapentin and tramadol were used in combination, gabapentin had no additive antinociceptive effect except for 300 mg/kg in tail-flick and hot-plate tests." | 1.38 | The antinociceptive effects of systemic administration of tramadol, gabapentin and their combination on mice model of acute pain. ( Alaçam, B; Aydin, ON; Ek, RO; Şen, S; Temoçin, S; Uğur, B, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 19 (95.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sadaeng, W | 1 |
| Márta, K | 1 |
| Mátrai, P | 1 |
| Hegyi, P | 1 |
| Tóth, B | 1 |
| Németh, B | 1 |
| Czumbel, LM | 1 |
| Sang-Ngoen, T | 1 |
| Gyöngyi, Z | 1 |
| Varga, G | 1 |
| Révész, P | 1 |
| Szanyi, I | 1 |
| Karádi, K | 1 |
| Gerber, G | 1 |
| Peng, C | 1 |
| Li, C | 1 |
| Qu, J | 1 |
| Wu, D | 1 |
| Jodoin, M | 1 |
| Rouleau, D | 1 |
| Larson-Dupuis, C | 1 |
| Gosselin, N | 1 |
| De Beaumont, L | 1 |
| Liu, B | 1 |
| Liu, R | 1 |
| Wang, L | 1 |
| Nesterkina, M | 1 |
| Kravchenko, I | 1 |
| Landau, R | 1 |
| Bollag, L | 1 |
| Ortner, C | 1 |
| George, RB | 1 |
| McKeen, DM | 1 |
| Andreou, P | 1 |
| Habib, AS | 2 |
| Chang, CY | 1 |
| Challa, CK | 1 |
| Shah, J | 1 |
| Eloy, JD | 1 |
| Mishriky, BM | 1 |
| Waldron, NH | 1 |
| Hummig, W | 1 |
| Kopruszinski, CM | 1 |
| Chichorro, JG | 1 |
| Cleve, M | 1 |
| Gussew, A | 1 |
| Reichenbach, JR | 1 |
| Shinde, SS | 1 |
| Seisler, D | 1 |
| Soori, G | 1 |
| Atherton, PJ | 1 |
| Pachman, DR | 1 |
| Lafky, J | 1 |
| Ruddy, KJ | 1 |
| Loprinzi, CL | 1 |
| Nottage, KA | 1 |
| Hankins, JS | 1 |
| Faughnan, LG | 1 |
| James, DM | 1 |
| Richardson, J | 1 |
| Christensen, R | 1 |
| Kang, G | 1 |
| Smeltzer, M | 1 |
| Cancio, MI | 1 |
| Wang, WC | 1 |
| Anghelescu, DL | 1 |
| Badiola, IJ | 1 |
| Raymond-Dufresne, E | 1 |
| Zhu, CZ | 1 |
| Mills, CD | 1 |
| Hsieh, GC | 1 |
| Zhong, C | 1 |
| Mikusa, J | 1 |
| Lewis, LG | 1 |
| Gauvin, D | 1 |
| Lee, CH | 1 |
| Decker, MW | 1 |
| Bannon, AW | 1 |
| Rueter, LE | 1 |
| Joshi, SK | 1 |
| Meymandi, MS | 1 |
| Keyhanfar, F | 1 |
| Luszczki, JJ | 1 |
| Florek-Łuszczki, M | 1 |
| Aydin, ON | 1 |
| Ek, RO | 1 |
| Temoçin, S | 1 |
| Uğur, B | 1 |
| Alaçam, B | 1 |
| Şen, S | 1 |
| Fassoulaki, A | 1 |
| Melemeni, A | 1 |
| Tsaroucha, A | 1 |
| Paraskeva, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| "Preoperative Gabapentin and Its Effects on Postoperative Analgesia in Patients Undergoing Cosmetic Breast Surgery"[NCT05997355] | 100 participants (Anticipated) | Interventional | 2023-09-01 | Not yet recruiting | |||
| A Randomized, Placebo Controlled Trial of Pregabalin for Post-operative Pain in Women Undergoing Abdominal Hysterectomy[NCT00781131] | Phase 4 | 101 participants (Actual) | Interventional | 2008-05-31 | Completed | ||
| Opioid-Free Shoulder Arthroplasty[NCT03540030] | Phase 4 | 86 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
| Effect of Two Different Doses of Oral Pregabalin Premedication for Postoperative Pain Relief After Gynecological Surgeries[NCT04708353] | 90 participants (Anticipated) | Interventional | 2020-08-20 | Recruiting | |||
| Psychosocial and Psychophysical Factors Influencing the Effect of Preemptive Systemic Analgesia in Combination With Regional Anesthesia on Postoperative Pain Following Upper Limb Surgery[NCT05248152] | 90 participants (Anticipated) | Interventional | 2022-01-13 | Recruiting | |||
| Efficacy of Different Doses of Pregabalin as a Multimodal Analgesic Agent in Postoperative Pain Control After Total Knee Arthroplasty - A Randomized Controlled Trial[NCT05447364] | Phase 4 | 82 participants (Anticipated) | Interventional | 2021-07-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
American Shoulder and Elbow Surgeons (ASES) Shoulder Score for pain and function. Range 0-100. Low score = worse shoulder condition. Function, disability, and pain subscores (all ranges 0-50), and are summed for total ASES score. (NCT03540030)
Timeframe: 2 Weeks
| Intervention | units on a scale (Median) |
|---|---|
| Observational | 54.3 |
| Non-Opioid Intervention | 54.2 |
Morphine milli-equivalents In-hospital post-operative. Continuous scale of MME, no defined better/worse. Measured as number and dose of medications taken. For example, if the patient received an opioid, the drug and dose was recorded and converted to MME. A time frame of when to assess opioid use in-hospital post-operative was not used but was a continuous monitor for rescue opioid from in-hospital post-operative through discharge. (NCT03540030)
Timeframe: In-hospital Stay
| Intervention | Morphine milli-equivalents (Median) |
|---|---|
| Observational | 45.0 |
| Non-Opioid Intervention | 19.0 |
Pain at patient discharge or 24-hours, whichever comes first - measured on a 0 (no pain) -10 (worst possible pain) numeric rating scale (NRS). A score of 0(no pain) is preferable to 10(worst possible pain) (NCT03540030)
Timeframe: 24 hours
| Intervention | score on a scale (Median) |
|---|---|
| Observational | 3.0 |
| Non-Opioid Intervention | 2.0 |
Simple Shoulder Test (SST) activity score. Range 0-12. 0 = worse activity score. (NCT03540030)
Timeframe: 2 Months
| Intervention | score on a scale (Median) |
|---|---|
| Observational | 6 |
| Non-Opioid Intervention | 6 |
Simple Shoulder Test (SST) activity score. Range 0-12. 0 = worse activity score. (NCT03540030)
Timeframe: 2 Weeks
| Intervention | score on a scale (Median) |
|---|---|
| Observational | 2.0 |
| Non-Opioid Intervention | 2.0 |
post-operative pain: measured on a 0 (no pain) -10 (worst) numeric rating scale (NRS) at 6hrs, 12hrs, 2 weeks, and 2 months. A score of 0(no pain) is preferable to 10(worst possible pain) (NCT03540030)
Timeframe: 6hrs, 12hrs, 2weeks, 2 months
| Intervention | score on a scale (Median) | |||
|---|---|---|---|---|
| 6 Hrs | 12 hrs | 2 weeks | 2 months | |
| Non-Opioid Intervention | 0.0 | 0 | 0.82 | 0 |
| Observational | 2 | 4 | 1.3 | 0.7 |
rate of constipation (NCT03540030)
Timeframe: 2 Months
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 4 | 27 | 4 |
| Observational | 7 | 21 | 2 |
rate of constipation (NCT03540030)
Timeframe: 2 Weeks
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 13 | 22 | 0 |
| Observational | 19 | 9 | 2 |
rate of falls (NCT03540030)
Timeframe: 2 Months
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 4 | 27 | 4 |
| Observational | 4 | 24 | 2 |
rate of falls (NCT03540030)
Timeframe: 2 Weeks
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 5 | 30 | 0 |
| Observational | 1 | 27 | 2 |
rate of nausea (NCT03540030)
Timeframe: 2 Months
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 1 | 30 | 0 |
| Observational | 0 | 28 | 2 |
rate of nausea (NCT03540030)
Timeframe: 2 Weeks
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 1 | 34 | 0 |
| Observational | 5 | 23 | 2 |
Satisfaction with overall pain using Numeric Pain Rating (NRS) scale. yes, no. No being better than yes. (NCT03540030)
Timeframe: 2 Months
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 29 | 2 | 4 |
| Observational | 23 | 5 | 2 |
Satisfaction with overall pain using Numeric Pain Rating (NRS) scale. yes, no. No being better than yes. (NCT03540030)
Timeframe: 2 Weeks
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 34 | 1 | 0 |
| Observational | 27 | 1 | 2 |
quality of life using VR-12 subscores. Physical Health (PCS) subscore and Mental Health (MCS) subscore, not summed. Range reported in weighted units. Physical Health subscore: 1 point increase in PCS is associated with 6% lower total health care expenditures, 5% lower pharmacy expenditures, 9% lower rate of hospital inpatient visits, 4% lower rate of medical provider visits, 5% lower rate of hospital outpatient visits. Mental Health sub score a 1 point increase in MCS is associated with 7% lower total health care expenditures, 4% lower pharmacy expenditures, 15% lower rate of hospital inpatient visits, and 4% lower rate of medical provider visits. Both PCS/MCS are score 0-100 with 100 indicating the highest level of health. (NCT03540030)
Timeframe: 2 Months
| Intervention | score on a scale (Median) | |
|---|---|---|
| PCS | MCS | |
| Non-Opioid Intervention | 40.3 | 60.8 |
| Observational | 38.4 | 58.7 |
quality of life using VR-12 subscores. Physical Health (PCS) subscore and Mental Health (MCS) subscore, not summed. Range reported in weighted units. Physical Health subscore: 1 point increase in PCS is associated with 6% lower total health care expenditures, 5% lower pharmacy expenditures, 9% lower rate of hospital inpatient visits, 4% lower rate of medical provider visits, 5% lower rate of hospital outpatient visits. Mental Health sub score a 1 point increase in MCS is associated with 7% lower total health care expenditures, 4% lower pharmacy expenditures, 15% lower rate of hospital inpatient visits, and 4% lower rate of medical provider visits. Both PCS/MCS are score 0-100 with 100 indicating the highest level of health. (NCT03540030)
Timeframe: 2 Weeks
| Intervention | score on a scale (Median) | |
|---|---|---|
| PCS | MCS | |
| Non-Opioid Intervention | 35.0 | 59.1 |
| Observational | 36.7 | 56.3 |
9 reviews available for gamma-aminobutyric acid and Acute Pain
| Article | Year |
|---|---|
γ-Aminobutyric Acid and Derivatives Reduce the Incidence of Acute Pain after Herpes Zoster - A Systematic Review and Meta-analysis.
Topics: Acute Pain; gamma-Aminobutyric Acid; Herpes Zoster; Humans; Incidence | 2020 |
Gabapentin can decrease acute pain and morphine consumption in spinal surgery patients: A meta-analysis of randomized controlled trials.
Topics: Acute Pain; Amines; Analgesics; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Gabap | 2017 |
The clinical utility of repetitive transcranial magnetic stimulation in reducing the risks of transitioning from acute to chronic pain in traumatically injured patients.
Topics: Acute Pain; Animals; Chronic Pain; Disease Progression; gamma-Aminobutyric Acid; Humans; Transcrania | 2018 |
A meta-analysis of the preoperative use of gabapentinoids for the treatment of acute postoperative pain following spinal surgery.
Topics: Acute Pain; Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Hu | 2017 |
Chronic pain after childbirth.
Topics: Acute Pain; Adrenergic alpha-Agonists; Adult; Amines; Analgesics; Anesthetics, Dissociative; Cesarea | 2013 |
Gabapentin in acute postoperative pain management.
Topics: Acute Pain; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric | 2014 |
Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis.
Topics: Acute Pain; Analgesics; Chronic Pain; gamma-Aminobutyric Acid; Humans; Pain, Postoperative; Pregabal | 2015 |
Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis.
Topics: Acute Pain; Analgesics; Chronic Pain; gamma-Aminobutyric Acid; Humans; Pain, Postoperative; Pregabal | 2015 |
Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis.
Topics: Acute Pain; Analgesics; Chronic Pain; gamma-Aminobutyric Acid; Humans; Pain, Postoperative; Pregabal | 2015 |
Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis.
Topics: Acute Pain; Analgesics; Chronic Pain; gamma-Aminobutyric Acid; Humans; Pain, Postoperative; Pregabal | 2015 |
Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis.
Topics: Acute Pain; Analgesics; Chronic Pain; gamma-Aminobutyric Acid; Humans; Pain, Postoperative; Pregabal | 2015 |
Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis.
Topics: Acute Pain; Analgesics; Chronic Pain; gamma-Aminobutyric Acid; Humans; Pain, Postoperative; Pregabal | 2015 |
Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis.
Topics: Acute Pain; Analgesics; Chronic Pain; gamma-Aminobutyric Acid; Humans; Pain, Postoperative; Pregabal | 2015 |
Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis.
Topics: Acute Pain; Analgesics; Chronic Pain; gamma-Aminobutyric Acid; Humans; Pain, Postoperative; Pregabal | 2015 |
Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis.
Topics: Acute Pain; Analgesics; Chronic Pain; gamma-Aminobutyric Acid; Humans; Pain, Postoperative; Pregabal | 2015 |
Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis.
Topics: Acute Pain; Analgesics; Chronic Pain; gamma-Aminobutyric Acid; Humans; Pain, Postoperative; Pregabal | 2015 |
Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis.
Topics: Acute Pain; Analgesics; Chronic Pain; gamma-Aminobutyric Acid; Humans; Pain, Postoperative; Pregabal | 2015 |
Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis.
Topics: Acute Pain; Analgesics; Chronic Pain; gamma-Aminobutyric Acid; Humans; Pain, Postoperative; Pregabal | 2015 |
Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis.
Topics: Acute Pain; Analgesics; Chronic Pain; gamma-Aminobutyric Acid; Humans; Pain, Postoperative; Pregabal | 2015 |
Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis.
Topics: Acute Pain; Analgesics; Chronic Pain; gamma-Aminobutyric Acid; Humans; Pain, Postoperative; Pregabal | 2015 |
Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis.
Topics: Acute Pain; Analgesics; Chronic Pain; gamma-Aminobutyric Acid; Humans; Pain, Postoperative; Pregabal | 2015 |
Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis.
Topics: Acute Pain; Analgesics; Chronic Pain; gamma-Aminobutyric Acid; Humans; Pain, Postoperative; Pregabal | 2015 |
Can Chronic Pain Be Prevented?
Topics: Acute Pain; Amines; Anesthesia, Conduction; Chronic Pain; Cyclohexanecarboxylic Acids; Epigenesis, G | 2016 |
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. BET 3: can pregabalin effectively diminish acute herpetic pain and reduce the incidence of post-herpetic neuralgia?
Topics: Acute Pain; Analgesics; Evidence-Based Medicine; gamma-Aminobutyric Acid; Herpes Simplex; Humans; In | 2012 |
4 trials available for gamma-aminobutyric acid and Acute Pain
| Article | Year |
|---|---|
A randomized placebo-controlled trial of two doses of pregabalin for postoperative analgesia in patients undergoing abdominal hysterectomy.
Topics: Acute Pain; Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Dose-Response Rela | 2014 |
Can pregabalin prevent paclitaxel-associated neuropathy?--An ACCRU pilot trial.
Topics: Acute Pain; Adult; Aged; Amines; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric | 2016 |
Addressing challenges of clinical trials in acute pain: The Pain Management of Vaso-occlusive Crisis in Children and Young Adults with Sickle Cell Disease Study.
Topics: Acute Disease; Acute Pain; Adolescent; Adult; Amines; Analgesics; Anemia, Sickle Cell; Child; Child, | 2016 |
Perioperative pregabalin for acute and chronic pain after abdominal hysterectomy or myomectomy: a randomised controlled trial.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics; Chronic Pain; Codeine; Double-Blind Method; Drug Combi | 2012 |
7 other studies available for gamma-aminobutyric acid and Acute Pain
| Article | Year |
|---|---|
Analgesic Activity of Novel GABA Esters after Transdermal Delivery.
Topics: Acute Pain; Administration, Cutaneous; Analgesics, Non-Narcotic; Animals; Capsaicin; Esters; Formald | 2016 |
Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain.
Topics: Acute Pain; Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Carrageenan; Chronic Pain; Dis | 2014 |
In vivo detection of acute pain-induced changes of GABA+ and Glx in the human brain by using functional 1H MEGA-PRESS MR spectroscopy.
Topics: Acute Pain; Brain; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Magnetic Resonance Spectr | 2015 |
Assessing carrageenan-induced locomotor activity impairment in rats: comparison with evoked endpoint of acute inflammatory pain.
Topics: Acute Pain; Adrenergic Uptake Inhibitors; Amines; Amphetamine; Analgesics; Analgesics, Opioid; Anima | 2012 |
Pregabalin antinociception and its interaction with tramadol in acute model of pain.
Topics: Acute Pain; Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relations | 2012 |
Synergistic interaction of pregabalin with the synthetic cannabinoid WIN 55,212-2 mesylate in the hot-plate test in mice: an isobolographic analysis.
Topics: Acute Pain; Analgesics; Animals; Benzoxazines; Disease Models, Animal; Dose-Response Relationship, D | 2012 |
The antinociceptive effects of systemic administration of tramadol, gabapentin and their combination on mice model of acute pain.
Topics: Acute Pain; Amines; Analgesics; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Mo | 2012 |