gamma-aminobutyric acid has been researched along with Acute Disease in 154 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Acute Disease: Disease having a short and relatively severe course.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Topiramate, a structurally novel anticonvulsant, is being evaluated for other neurological conditions such as migraine, neuropathic pain, and essential tremor, and also for psychiatric conditions such as bipolar disorder, bulimia, post-traumatic stress disorder, and schizoaffective disorder, in addition to obesity." | 10.19 | The evolving role of topiramate among other mood stabilizers in the management of bipolar disorder. ( Chengappa, KN; Gershon, S; Levine, J, 2001) |
| "The pharmacological profile of topiramate is compared to other established and putative mood stabilizers, and a rationale for its use in bipolar disorder is presented." | 10.19 | The evolving role of topiramate among other mood stabilizers in the management of bipolar disorder. ( Chengappa, KN; Gershon, S; Levine, J, 2001) |
| "Topiramate appears to show promise as an addition to the agents available to treat bipolar disorder." | 10.19 | The evolving role of topiramate among other mood stabilizers in the management of bipolar disorder. ( Chengappa, KN; Gershon, S; Levine, J, 2001) |
| "The study did not prove any statistically significant effect of pregabalin in pain relief in patients with acute zoster pain or in the onset of postherpetic neuralgia in comparison with the placebo." | 9.14 | Effects of pregabalin on acute herpetic pain and postherpetic neuralgia incidence. ( Kamenik, M; Krcevski Skvarc, N, 2010) |
| "This randomized, double-blind, placebo-controlled crossover study measured the effect of a single dose of oral gabapentin (900 mg) on pain and allodynia associated with herpes zoster." | 9.11 | A single dose of gabapentin reduces acute pain and allodynia in patients with herpes zoster. ( Berry, JD; Petersen, KL, 2005) |
| "Pregabalin has proven efficacy in neuropathic pain conditions and fibromyalgia." | 8.85 | Pregabalin for acute and chronic pain in adults. ( Derry, S; McQuay, HJ; Moore, RA; Straube, S; Wiffen, PJ, 2009) |
| "To assess analgesic efficacy and associated adverse events of pregabalin in acute and chronic pain." | 8.85 | Pregabalin for acute and chronic pain in adults. ( Derry, S; McQuay, HJ; Moore, RA; Straube, S; Wiffen, PJ, 2009) |
| "Randomised, double blind trials reporting on the analgesic effect of pregabalin, with subjective pain assessment by the patient as either the primary or a secondary outcome." | 8.85 | Pregabalin for acute and chronic pain in adults. ( Derry, S; McQuay, HJ; Moore, RA; Straube, S; Wiffen, PJ, 2009) |
| "There was no clear evidence of beneficial effects of pregabalin in established acute postoperative pain." | 8.85 | Pregabalin for acute and chronic pain in adults. ( Derry, S; McQuay, HJ; Moore, RA; Straube, S; Wiffen, PJ, 2009) |
| "To evaluate the analgesic effectiveness and adverse effects of gabapentin for pain management in clinical practice." | 8.82 | Gabapentin for acute and chronic pain. ( Edwards, JE; McQuay, HJ; Moore, RA; Wiffen, PJ, 2005) |
| "Randomised trials of gabapentin in acute, chronic or cancer pain were identified by MEDLINE (1966-Nov 2004), EMBASE (1994-Nov 2004), SIGLE (1980-Jan 2004) and the Cochrane Central Register of Controlled Trials (CENTRAL) (Cochrane Library Issue 4, 2004)." | 8.82 | Gabapentin for acute and chronic pain. ( Edwards, JE; McQuay, HJ; Moore, RA; Wiffen, PJ, 2005) |
| "Randomised trials reporting the analgesic effects of gabapentin in patients, with subjective pain assessment as either the primary or a secondary outcome." | 8.82 | Gabapentin for acute and chronic pain. ( Edwards, JE; McQuay, HJ; Moore, RA; Wiffen, PJ, 2005) |
| "There is evidence to show that gabapentin is effective in neuropathic pain." | 8.82 | Gabapentin for acute and chronic pain. ( Edwards, JE; McQuay, HJ; Moore, RA; Wiffen, PJ, 2005) |
| "Latrunculin A microperfusion of the hippocampus induces acute epileptic seizures and long-term biochemical changes leading to spontaneous seizures." | 7.80 | Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus. ( Loureiro, AI; Sierra-Marcuño, G; Sierra-Paredes, G; Soares-da-Silva, P; Wright, LC, 2014) |
| "Oral administration of ESL (100 mg/kg), previous to latrunculin A microperfusion, completely prevented acute latrunculin A-induced seizures as well as chronic seizures and all EEG chronic signs of paroxysmal activity." | 7.80 | Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus. ( Loureiro, AI; Sierra-Marcuño, G; Sierra-Paredes, G; Soares-da-Silva, P; Wright, LC, 2014) |
| "ESL treatment prevented acute latrunculin A-induced seizures as well as chronic seizures and all EEG chronic signs of paroxysmal activity, supporting a possible anti-epileptogenic effect of ESL in mice." | 7.80 | Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus. ( Loureiro, AI; Sierra-Marcuño, G; Sierra-Paredes, G; Soares-da-Silva, P; Wright, LC, 2014) |
| " Approximately 30-40% of brain tumors patients who present with status epilepticus (SE) will not respond to typical therapy consisting of benzodiazepines and phenytoin (PHT), resulting in patients with refractory status epilepticus (RSE)." | 7.78 | Phenytoin, levetiracetam, and pregabalin in the acute management of refractory status epilepticus in patients with brain tumors. ( Doreswamy, M; Gingrich, KJ; Kolls, BJ; Swisher, CB; Vredenburgh, JJ, 2012) |
| "To evaluate the efficacy of treatment with gabapentin plus valacyclovir hydrochloride for the prevention of postherpetic neuralgia in patients with acute herpes zoster." | 7.77 | Incidence of postherpetic neuralgia after combination treatment with gabapentin and valacyclovir in patients with acute herpes zoster: open-label study. ( Digiorgio, C; Grady, J; Haitz, K; Lapolla, W; Lu, W; Magel, G; Mendoza, N; Tyring, S, 2011) |
| "The combination of gabapentin and valacyclovir administered acutely in patients with herpes zoster reduces the incidence of postherpetic neuralgia." | 7.77 | Incidence of postherpetic neuralgia after combination treatment with gabapentin and valacyclovir in patients with acute herpes zoster: open-label study. ( Digiorgio, C; Grady, J; Haitz, K; Lapolla, W; Lu, W; Magel, G; Mendoza, N; Tyring, S, 2011) |
| "The anticonvulsant gabapentin (GBP) has been shown effective for the treatment of neuropathic pain, although its mechanism of action remains unclear." | 7.73 | Comparison of the antinociceptive profiles of gabapentin and 3-methylgabapentin in rat models of acute and persistent pain: implications for mechanism of action. ( Aiyar, J; Anker, N; Belley, M; Bristow, L; Campbell, B; Cohen, C; Park, KT; Ren, K; Stearns, B; Urban, MO, 2005) |
| "Mice were administered by gastric tube with fipronil at six doses and their behavioral changes, pathological changes in their major viscera under light and electron microscopy and deaths were observed after acute poisoning." | 7.73 | [An experimental study on acute poisoning by fipronil in mice and its pharmaceutical therapy]. ( He, GX; Hu, GX; Lu, ZQ; Qiu, QM, 2006) |
| "Mice with acute poisoning by fipronil appeared exciting symptoms in CNS, leading to damage in its nerve cells." | 7.73 | [An experimental study on acute poisoning by fipronil in mice and its pharmaceutical therapy]. ( He, GX; Hu, GX; Lu, ZQ; Qiu, QM, 2006) |
| "Combined spinal administration of gabapentin and low doses of morphine significantly reduces pain-related behaviors in this acute rat pancreatitis model, whereas these agents were ineffective when used alone in this dose range." | 7.72 | Intrathecal gabapentin enhances the analgesic effects of subtherapeutic dose morphine in a rat experimental pancreatitis model. ( Lu, Y; Smiley, MM; Vera-Portocarrero, LP; Westlund, KN; Zidan, A, 2004) |
| " In this study, intrathecal gabapentin, which by itself is ineffective when administered spinally, was combined with low-dose morphine and tested in an acute bradykinin-induced pancreatitis model in rats." | 7.72 | Intrathecal gabapentin enhances the analgesic effects of subtherapeutic dose morphine in a rat experimental pancreatitis model. ( Lu, Y; Smiley, MM; Vera-Portocarrero, LP; Westlund, KN; Zidan, A, 2004) |
| "To present two years of experience in the use of gabapentin for the alleviation of neuropathic pain in spinal cord injury patients." | 7.71 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "Data were retrieved from the medical records of all spinal cord injury patients prescribed gabapentin for neuropathic pain." | 7.71 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "Seventy-six per cent of patients receiving gabapentin reported a reduction in neuropathic pain." | 7.71 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "Our experience suggests that gabapentin offers an effective therapeutic alternative for the alleviation of neuropathic pain following spinal cord injury." | 7.71 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "This report describes the results of maintenance treatment with gabapentin in 18 previously refractory Bipolar Disorder patients who initially responded to augmentation with gabapentin during the acute phase of their therapy." | 7.70 | Open maintenance treatment of bipolar disorder spectrum patients who responded to gabapentin augmentation in the acute phase of treatment. ( Schaffer, CB; Schaffer, LC, 1999) |
| "Reductions in allodynia area and severity, and overall pain relief, were also greater with gabapentin." | 6.71 | A single dose of gabapentin reduces acute pain and allodynia in patients with herpes zoster. ( Berry, JD; Petersen, KL, 2005) |
| "Gabapentin was well tolerated by all patients, with the most common side-effect being sedation." | 6.69 | Gabapentin in the acute treatment of refractory bipolar disorder. ( Altshuler, LL; Brown, ES; Denicoff, K; Frye, M; Gitlin, M; Goodman, R; Hwang, S; Keck, PE; Kupka, R; Leverich, G; McElroy, SL; Nolen, W; Post, R; Suppes, T, 1999) |
| "Fourteen of the 18 (78%) treated for hypomania or mania had a positive response to a dosage range of 600-3,600 mg/day." | 6.69 | Gabapentin in the acute treatment of refractory bipolar disorder. ( Altshuler, LL; Brown, ES; Denicoff, K; Frye, M; Gitlin, M; Goodman, R; Hwang, S; Keck, PE; Kupka, R; Leverich, G; McElroy, SL; Nolen, W; Post, R; Suppes, T, 1999) |
| "Multimodal treatment of postoperative pain using adjuncts such as gabapentin is becoming more common." | 6.47 | Efficacy of pregabalin in acute postoperative pain: a meta-analysis. ( Ho, KY; Wang, Y; Zhang, J, 2011) |
| "Gabapentin is an antiepileptic drug, also used in the treatment of neuropathic pain, which is the subject of a Cochrane review, currently under revision." | 6.46 | Single dose oral gabapentin for established acute postoperative pain in adults. ( Derry, S; McQuay, HJ; Moore, RA; Straube, S; Wiffen, PJ, 2010) |
| "Its efficacy in treating established acute postoperative pain has not been demonstrated." | 6.46 | Single dose oral gabapentin for established acute postoperative pain in adults. ( Derry, S; McQuay, HJ; Moore, RA; Straube, S; Wiffen, PJ, 2010) |
| "Topiramate, a structurally novel anticonvulsant, is being evaluated for other neurological conditions such as migraine, neuropathic pain, and essential tremor, and also for psychiatric conditions such as bipolar disorder, bulimia, post-traumatic stress disorder, and schizoaffective disorder, in addition to obesity." | 6.19 | The evolving role of topiramate among other mood stabilizers in the management of bipolar disorder. ( Chengappa, KN; Gershon, S; Levine, J, 2001) |
| "The pharmacological profile of topiramate is compared to other established and putative mood stabilizers, and a rationale for its use in bipolar disorder is presented." | 6.19 | The evolving role of topiramate among other mood stabilizers in the management of bipolar disorder. ( Chengappa, KN; Gershon, S; Levine, J, 2001) |
| "Topiramate appears to show promise as an addition to the agents available to treat bipolar disorder." | 6.19 | The evolving role of topiramate among other mood stabilizers in the management of bipolar disorder. ( Chengappa, KN; Gershon, S; Levine, J, 2001) |
| "Approximately 30-40% of brain tumors patients who present with status epilepticus (SE) will not respond to typical therapy consisting of benzodiazepines and phenytoin (PHT), resulting in patients with refractory status epilepticus (RSE)." | 5.38 | Phenytoin, levetiracetam, and pregabalin in the acute management of refractory status epilepticus in patients with brain tumors. ( Doreswamy, M; Gingrich, KJ; Kolls, BJ; Swisher, CB; Vredenburgh, JJ, 2012) |
| "Acute hypotension was induced by intravenous infusion of sodium nitroprusside (SNP)." | 5.36 | [Changes of gamma-aminobutyric acid and glycine released in the medial vestibular nucleus following acute hypotension in conscious rats]. ( An, Y; Jin, QH; Jin, YZ; Li, XL, 2010) |
| "Morphine pretreatment produced an increase in GABA levels and a decrease in glutamate levels in the first few minutes." | 5.35 | [Effect of a simple morphine system injection in some aminoacids in the anterior cingulate cortex during acute pain]. ( Hernández, L; Páez, X; Quiñones, B; Silva, E, 2008) |
| "Pretreatment with morphine suppressed the glutamate increase." | 5.35 | [Effect of a simple morphine system injection in some aminoacids in the anterior cingulate cortex during acute pain]. ( Hernández, L; Páez, X; Quiñones, B; Silva, E, 2008) |
| "Seizures were detected by continuous electroencephalographic monitoring for 24 h following permanent middle cerebral artery occlusion (MCAo)." | 5.33 | Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats. ( Bautista, CC; Chen, RW; Dave, JR; Hartings, JA; Lu, XC; Tortella, FC; Williams, AJ, 2006) |
| "Acute seizures following brain injury have been associated with a worsening of patient outcome, but they are often undiagnosed and untreated when they occur without motor convulsions." | 5.33 | Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats. ( Bautista, CC; Chen, RW; Dave, JR; Hartings, JA; Lu, XC; Tortella, FC; Williams, AJ, 2006) |
| "Morphine sulfate has long been used for analgesia, but clinical applications can be limited by side effects, tolerance, and potential for addiction at therapeutic doses." | 5.32 | Intrathecal gabapentin enhances the analgesic effects of subtherapeutic dose morphine in a rat experimental pancreatitis model. ( Lu, Y; Smiley, MM; Vera-Portocarrero, LP; Westlund, KN; Zidan, A, 2004) |
| "Neurogenic inflammation is an inflammatory response of peripheral tissue to vasoactive substances released from sensory afferent terminals." | 5.31 | Activation of spinal ORL-1 receptors prevents acute cutaneous neurogenic inflammation: role of nociceptin-induced suppression of primary afferent depolarization. ( Dong, XW; Jia, YP; Priestley, T; Williams, PA, 2002) |
| "Pain was assessed prior to and during treatment at 1, 3 and 6 months with a 10 cm visual analogue scale which ranged from 0 ('no pain') to 10 ('worst pain imaginable'), or by the documentation of a verbal description of pain." | 5.31 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "In this clinical trial, we studied the effects of adjunctive treatment with gabapentin in controlling the symptoms of acute mania in patients admitted with bipolar disorder." | 5.16 | Adjunctive treatment with gabapentin in bipolar patients during acute mania. ( Astaneh, AN; Rezaei, O, 2012) |
| "The purpose of this study was to evaluate the analgesic effects of perioperative gabapentin on postoperative acute and chronic pain after coronary artery bypass graft (CABG) surgery with median sternotomy and internal mammary artery harvesting." | 5.15 | The effects of gabapentin on acute and chronic postoperative pain after coronary artery bypass graft surgery. ( Onan, B; Selcuk, I; Sen, H; Turan, A; Ucak, A; Yilmaz, AT, 2011) |
| " Up to estimated 336 patients (interim analyses) with acute herpes zoster pain (VAS > 30 mm) will be randomised to one of three groups (a) semi-standardised acupuncture (168 patients); (b) gabapentine with individualised dosage between 900-3600 mg/d (84 patients); (c) sham laser acupuncture." | 5.14 | Acupuncture in acute herpes zoster pain therapy (ACUZoster) - design and protocol of a randomised controlled trial. ( Fleckenstein, J; Hoffrogge, P; Irnich, D; Kramer, S; Lang, PM; Lehmeyer, L; Mansmann, U; Pfab, F; Ring, J; Schober, GM; Schotten, KJ; Thoma, S; Weisenseel, P, 2009) |
| "This study is the first large-scale randomised placebo controlled trial to evaluate the efficacy of acupuncture compared to gabapentine and sham treatment and will provide valuable new information about the clinical and physiological effects of acupuncture and gabapentine in the treatment of acute herpes zoster pain." | 5.14 | Acupuncture in acute herpes zoster pain therapy (ACUZoster) - design and protocol of a randomised controlled trial. ( Fleckenstein, J; Hoffrogge, P; Irnich, D; Kramer, S; Lang, PM; Lehmeyer, L; Mansmann, U; Pfab, F; Ring, J; Schober, GM; Schotten, KJ; Thoma, S; Weisenseel, P, 2009) |
| "The study did not prove any statistically significant effect of pregabalin in pain relief in patients with acute zoster pain or in the onset of postherpetic neuralgia in comparison with the placebo." | 5.14 | Effects of pregabalin on acute herpetic pain and postherpetic neuralgia incidence. ( Kamenik, M; Krcevski Skvarc, N, 2010) |
| "This randomized, double-blind, placebo-controlled crossover study measured the effect of a single dose of oral gabapentin (900 mg) on pain and allodynia associated with herpes zoster." | 5.11 | A single dose of gabapentin reduces acute pain and allodynia in patients with herpes zoster. ( Berry, JD; Petersen, KL, 2005) |
| " Fifty patients scheduled for breast cancer surgery were blindly randomized to receive gabapentin, eutectic mixture of local anesthetics cream, and ropivacaine in the wound or three placebos." | 5.11 | Multimodal analgesia with gabapentin and local anesthetics prevents acute and chronic pain after breast surgery for cancer. ( Fassoulaki, A; Melemeni, A; Sarantopoulos, C; Triga, A, 2005) |
| "This review provides moderate-quality evidence that fails to support the use of GABA receptor agonists (chlormethiazole or diazepam) for the treatment of people with acute stroke." | 4.98 | Gamma aminobutyric acid (GABA) receptor agonists for acute stroke. ( Liu, J; Wang, LN; Zhang, J, 2018) |
| " Pregabalin seems to provide clinically benefit to patients with fibromyalgia." | 4.85 | [Innovations in ambulatory care]. ( Bodenmann, P; Chapuis, T; Cornuz, J; de Bosset, V; Jaunin-Stalder, N; Marguerat, I; Nanchen, D; Pasche, O, 2009) |
| "Pregabalin has proven efficacy in neuropathic pain conditions and fibromyalgia." | 4.85 | Pregabalin for acute and chronic pain in adults. ( Derry, S; McQuay, HJ; Moore, RA; Straube, S; Wiffen, PJ, 2009) |
| "To assess analgesic efficacy and associated adverse events of pregabalin in acute and chronic pain." | 4.85 | Pregabalin for acute and chronic pain in adults. ( Derry, S; McQuay, HJ; Moore, RA; Straube, S; Wiffen, PJ, 2009) |
| "Randomised, double blind trials reporting on the analgesic effect of pregabalin, with subjective pain assessment by the patient as either the primary or a secondary outcome." | 4.85 | Pregabalin for acute and chronic pain in adults. ( Derry, S; McQuay, HJ; Moore, RA; Straube, S; Wiffen, PJ, 2009) |
| "There was no clear evidence of beneficial effects of pregabalin in established acute postoperative pain." | 4.85 | Pregabalin for acute and chronic pain in adults. ( Derry, S; McQuay, HJ; Moore, RA; Straube, S; Wiffen, PJ, 2009) |
| "To evaluate the analgesic effectiveness and adverse effects of gabapentin for pain management in clinical practice." | 4.82 | Gabapentin for acute and chronic pain. ( Edwards, JE; McQuay, HJ; Moore, RA; Wiffen, PJ, 2005) |
| "Randomised trials of gabapentin in acute, chronic or cancer pain were identified by MEDLINE (1966-Nov 2004), EMBASE (1994-Nov 2004), SIGLE (1980-Jan 2004) and the Cochrane Central Register of Controlled Trials (CENTRAL) (Cochrane Library Issue 4, 2004)." | 4.82 | Gabapentin for acute and chronic pain. ( Edwards, JE; McQuay, HJ; Moore, RA; Wiffen, PJ, 2005) |
| "Randomised trials reporting the analgesic effects of gabapentin in patients, with subjective pain assessment as either the primary or a secondary outcome." | 4.82 | Gabapentin for acute and chronic pain. ( Edwards, JE; McQuay, HJ; Moore, RA; Wiffen, PJ, 2005) |
| "There is evidence to show that gabapentin is effective in neuropathic pain." | 4.82 | Gabapentin for acute and chronic pain. ( Edwards, JE; McQuay, HJ; Moore, RA; Wiffen, PJ, 2005) |
| "A 7-year-old boy with intractable epilepsy developed acute psychosis 3 days after initiating a rapid vigabatrin dosage escalation." | 4.79 | Vigabatrin-associated reversible acute psychosis in a child. ( Beltrán Marqués, M; Cánovas Martínez, A; Delgado Cordón, F; Escrivá Aparisi, A; Ordovás Baines, JP, 1995) |
| "Latrunculin A microperfusion of the hippocampus induces acute epileptic seizures and long-term biochemical changes leading to spontaneous seizures." | 3.80 | Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus. ( Loureiro, AI; Sierra-Marcuño, G; Sierra-Paredes, G; Soares-da-Silva, P; Wright, LC, 2014) |
| "Oral administration of ESL (100 mg/kg), previous to latrunculin A microperfusion, completely prevented acute latrunculin A-induced seizures as well as chronic seizures and all EEG chronic signs of paroxysmal activity." | 3.80 | Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus. ( Loureiro, AI; Sierra-Marcuño, G; Sierra-Paredes, G; Soares-da-Silva, P; Wright, LC, 2014) |
| "ESL treatment prevented acute latrunculin A-induced seizures as well as chronic seizures and all EEG chronic signs of paroxysmal activity, supporting a possible anti-epileptogenic effect of ESL in mice." | 3.80 | Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus. ( Loureiro, AI; Sierra-Marcuño, G; Sierra-Paredes, G; Soares-da-Silva, P; Wright, LC, 2014) |
| " Approximately 30-40% of brain tumors patients who present with status epilepticus (SE) will not respond to typical therapy consisting of benzodiazepines and phenytoin (PHT), resulting in patients with refractory status epilepticus (RSE)." | 3.78 | Phenytoin, levetiracetam, and pregabalin in the acute management of refractory status epilepticus in patients with brain tumors. ( Doreswamy, M; Gingrich, KJ; Kolls, BJ; Swisher, CB; Vredenburgh, JJ, 2012) |
| "To evaluate the efficacy of treatment with gabapentin plus valacyclovir hydrochloride for the prevention of postherpetic neuralgia in patients with acute herpes zoster." | 3.77 | Incidence of postherpetic neuralgia after combination treatment with gabapentin and valacyclovir in patients with acute herpes zoster: open-label study. ( Digiorgio, C; Grady, J; Haitz, K; Lapolla, W; Lu, W; Magel, G; Mendoza, N; Tyring, S, 2011) |
| "The combination of gabapentin and valacyclovir administered acutely in patients with herpes zoster reduces the incidence of postherpetic neuralgia." | 3.77 | Incidence of postherpetic neuralgia after combination treatment with gabapentin and valacyclovir in patients with acute herpes zoster: open-label study. ( Digiorgio, C; Grady, J; Haitz, K; Lapolla, W; Lu, W; Magel, G; Mendoza, N; Tyring, S, 2011) |
| "Impaired function of the central gamma-aminobutyric acid (GABA) system, which provides the brain's major inhibitory pathways, is thought to play an important role in the pathophysiology of anxiety disorders." | 3.76 | Effect of acute psychological stress on prefrontal GABA concentration determined by proton magnetic resonance spectroscopy. ( Drevets, WC; Grillon, C; Hasler, G; Shen, J; van der Veen, JW, 2010) |
| "To determine whether altered central and/or peripheral gamma-aminobutyric acid (GABA)ergic mechanisms acting in GABA(A) receptors contribute to the abnormal ventilatory response to acute and sustained hypoxia in obese Zucker rats." | 3.73 | GABAergic modulation of ventilatory response to acute and sustained hypoxia in obese Zucker rats. ( Huang, CY; Lee, SD; Lin, TB; Lo, MJ; Ting, H, 2005) |
| "The anticonvulsant gabapentin (GBP) has been shown effective for the treatment of neuropathic pain, although its mechanism of action remains unclear." | 3.73 | Comparison of the antinociceptive profiles of gabapentin and 3-methylgabapentin in rat models of acute and persistent pain: implications for mechanism of action. ( Aiyar, J; Anker, N; Belley, M; Bristow, L; Campbell, B; Cohen, C; Park, KT; Ren, K; Stearns, B; Urban, MO, 2005) |
| "Mice were administered by gastric tube with fipronil at six doses and their behavioral changes, pathological changes in their major viscera under light and electron microscopy and deaths were observed after acute poisoning." | 3.73 | [An experimental study on acute poisoning by fipronil in mice and its pharmaceutical therapy]. ( He, GX; Hu, GX; Lu, ZQ; Qiu, QM, 2006) |
| "Mice with acute poisoning by fipronil appeared exciting symptoms in CNS, leading to damage in its nerve cells." | 3.73 | [An experimental study on acute poisoning by fipronil in mice and its pharmaceutical therapy]. ( He, GX; Hu, GX; Lu, ZQ; Qiu, QM, 2006) |
| "Combined spinal administration of gabapentin and low doses of morphine significantly reduces pain-related behaviors in this acute rat pancreatitis model, whereas these agents were ineffective when used alone in this dose range." | 3.72 | Intrathecal gabapentin enhances the analgesic effects of subtherapeutic dose morphine in a rat experimental pancreatitis model. ( Lu, Y; Smiley, MM; Vera-Portocarrero, LP; Westlund, KN; Zidan, A, 2004) |
| " In this study, intrathecal gabapentin, which by itself is ineffective when administered spinally, was combined with low-dose morphine and tested in an acute bradykinin-induced pancreatitis model in rats." | 3.72 | Intrathecal gabapentin enhances the analgesic effects of subtherapeutic dose morphine in a rat experimental pancreatitis model. ( Lu, Y; Smiley, MM; Vera-Portocarrero, LP; Westlund, KN; Zidan, A, 2004) |
| "To present two years of experience in the use of gabapentin for the alleviation of neuropathic pain in spinal cord injury patients." | 3.71 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "Data were retrieved from the medical records of all spinal cord injury patients prescribed gabapentin for neuropathic pain." | 3.71 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "Seventy-six per cent of patients receiving gabapentin reported a reduction in neuropathic pain." | 3.71 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "Our experience suggests that gabapentin offers an effective therapeutic alternative for the alleviation of neuropathic pain following spinal cord injury." | 3.71 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "This report describes the results of maintenance treatment with gabapentin in 18 previously refractory Bipolar Disorder patients who initially responded to augmentation with gabapentin during the acute phase of their therapy." | 3.70 | Open maintenance treatment of bipolar disorder spectrum patients who responded to gabapentin augmentation in the acute phase of treatment. ( Schaffer, CB; Schaffer, LC, 1999) |
| "The novel anti-epileptic drugs lamotrigine, felbamate and gabapentin were compared in rat experimental models of acute (tail flick) and chronic pain: the chronic constriction injury and spinal nerve ligation models." | 3.69 | The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain. ( Fontana, DJ; Gogas, KR; Hedley, LR; Hunter, JC; Jacobson, LO; Kassotakis, L; Thompson, J, 1997) |
| "The binding of [3H]GABA to GABAA and GABAB binding sites was measured in cerebral cortical membranes derived from control rats and rats with acute hepatic encephalopathy (HE) induced with a hepatotoxin, thioacetamide." | 3.68 | Loss of GABAB binding sites in the cerebral cortex of rats with acute hepatic encephalopathy. ( Albrecht, J; Oja, SS; Saransaari, P; Wysmyk, U, 1993) |
| "Trials of acute pain are complicated by the need to obtain consent, to randomize participants expeditiously while optimally treating pain." | 2.82 | Addressing challenges of clinical trials in acute pain: The Pain Management of Vaso-occlusive Crisis in Children and Young Adults with Sickle Cell Disease Study. ( Anghelescu, DL; Cancio, MI; Christensen, R; Faughnan, LG; Hankins, JS; James, DM; Kang, G; Nottage, KA; Richardson, J; Smeltzer, M; Wang, WC, 2016) |
| "The assessment of postoperative pain at the 1- and 3-month follow-ups was performed using a numeric rating scale." | 2.76 | The effects of gabapentin on acute and chronic postoperative pain after coronary artery bypass graft surgery. ( Onan, B; Selcuk, I; Sen, H; Turan, A; Ucak, A; Yilmaz, AT, 2011) |
| "Gabapentin has opioid-sparing effects in adult surgical patients, but no reported studies have involved children and adolescents." | 2.75 | Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. ( Berens, RJ; Czarnecki, ML; Hainsworth, KR; Lyon, RM; Nelson, TJ; Rusy, LM; Tassone, JC; Thometz, JG; Weisman, SJ, 2010) |
| " Up to estimated 336 patients (interim analyses) with acute herpes zoster pain (VAS > 30 mm) will be randomised to one of three groups (a) semi-standardised acupuncture (168 patients); (b) gabapentine with individualised dosage between 900-3600 mg/d (84 patients); (c) sham laser acupuncture." | 2.74 | Acupuncture in acute herpes zoster pain therapy (ACUZoster) - design and protocol of a randomised controlled trial. ( Fleckenstein, J; Hoffrogge, P; Irnich, D; Kramer, S; Lang, PM; Lehmeyer, L; Mansmann, U; Pfab, F; Ring, J; Schober, GM; Schotten, KJ; Thoma, S; Weisenseel, P, 2009) |
| "Acute herpes zoster is a prevalent condition." | 2.74 | Acupuncture in acute herpes zoster pain therapy (ACUZoster) - design and protocol of a randomised controlled trial. ( Fleckenstein, J; Hoffrogge, P; Irnich, D; Kramer, S; Lang, PM; Lehmeyer, L; Mansmann, U; Pfab, F; Ring, J; Schober, GM; Schotten, KJ; Thoma, S; Weisenseel, P, 2009) |
| "Reductions in allodynia area and severity, and overall pain relief, were also greater with gabapentin." | 2.71 | A single dose of gabapentin reduces acute pain and allodynia in patients with herpes zoster. ( Berry, JD; Petersen, KL, 2005) |
| "Fifty patients scheduled for breast cancer surgery were blindly randomized to receive gabapentin, eutectic mixture of local anesthetics cream, and ropivacaine in the wound or three placebos." | 2.71 | Multimodal analgesia with gabapentin and local anesthetics prevents acute and chronic pain after breast surgery for cancer. ( Fassoulaki, A; Melemeni, A; Sarantopoulos, C; Triga, A, 2005) |
| "Gabapentin was effective in the treatment of mania and hypomania in patients with bipolar and schizoaffective disorders." | 2.69 | Clinical experience with gabapentin in patients with bipolar or schizoaffective disorder: results of an open-label study. ( Cabras, PL; Carta, MG; Hardoy, MC; Hardoy, MJ, 1999) |
| "Gabapentin was well tolerated by all patients, with the most common side-effect being sedation." | 2.69 | Gabapentin in the acute treatment of refractory bipolar disorder. ( Altshuler, LL; Brown, ES; Denicoff, K; Frye, M; Gitlin, M; Goodman, R; Hwang, S; Keck, PE; Kupka, R; Leverich, G; McElroy, SL; Nolen, W; Post, R; Suppes, T, 1999) |
| "Fourteen of the 18 (78%) treated for hypomania or mania had a positive response to a dosage range of 600-3,600 mg/day." | 2.69 | Gabapentin in the acute treatment of refractory bipolar disorder. ( Altshuler, LL; Brown, ES; Denicoff, K; Frye, M; Gitlin, M; Goodman, R; Hwang, S; Keck, PE; Kupka, R; Leverich, G; McElroy, SL; Nolen, W; Post, R; Suppes, T, 1999) |
| "Somnolence and rhinitis are frequent adverse events related to chlormethiazole." | 2.58 | Gamma aminobutyric acid (GABA) receptor agonists for acute stroke. ( Liu, J; Wang, LN; Zhang, J, 2018) |
| "Multimodal treatment of postoperative pain using adjuncts such as gabapentin is becoming more common." | 2.47 | Efficacy of pregabalin in acute postoperative pain: a meta-analysis. ( Ho, KY; Wang, Y; Zhang, J, 2011) |
| "Migraine and headache studies are excluded in this revision." | 2.46 | WITHDRAWN. Anticonvulsant drugs for acute and chronic pain. ( Carroll, D; Collins, S; Jadad, A; McQuay, HJ; Moore, RA; Wiffen, PJ, 2010) |
| "Gabapentin is an antiepileptic drug, also used in the treatment of neuropathic pain, which is the subject of a Cochrane review, currently under revision." | 2.46 | Single dose oral gabapentin for established acute postoperative pain in adults. ( Derry, S; McQuay, HJ; Moore, RA; Straube, S; Wiffen, PJ, 2010) |
| "Its efficacy in treating established acute postoperative pain has not been demonstrated." | 2.46 | Single dose oral gabapentin for established acute postoperative pain in adults. ( Derry, S; McQuay, HJ; Moore, RA; Straube, S; Wiffen, PJ, 2010) |
| "Multimodal postoperative pain management targeted at diminishing harmful outcomes should include pregabalin in cases that need opioid reduction and when the risk of developing chronic neuropathic postsurgical pain is present." | 2.46 | Pregabalin for the treatment of postsurgical pain. ( Durkin, B; Glass, P; Page, C, 2010) |
| "There is a general agreement now that migraine is not only a vascular phenomenon but also a genetically determined heterogenic ion-channelopathy resulting in cortical-spreading-depression-like events, the temporary impairment of antinociceptive structures of the brainstem and the activation of the trigeminal-vascular system." | 2.44 | GABAergic drugs for the treatment of migraine. ( Limmroth, V; Puppe, A, 2007) |
| "Migraine and headache studies are excluded in this revision." | 2.43 | Anticonvulsant drugs for acute and chronic pain. ( Carroll, D; Collins, S; Jadad, A; McQuay, H; Moore, A; Wiffen, P, 2005) |
| "When gabapentin was administered at doses less than 1200 mg, pain intensity was also lower at 6 h (WMD, -22." | 2.43 | Gabapentin and postoperative pain--a systematic review of randomized controlled trials. ( Gan, TJ; Habib, AS; Ho, KY, 2006) |
| "Weighted mean difference (WMD) for postoperative pain intensity (0-100 mm visual analogue scale) was -16." | 2.43 | Gabapentin and postoperative pain--a systematic review of randomized controlled trials. ( Gan, TJ; Habib, AS; Ho, KY, 2006) |
| "A 7-year-old boy with intractable epilepsy developed acute psychosis 3 days after initiating a rapid vigabatrin dosage escalation." | 2.39 | Vigabatrin-associated reversible acute psychosis in a child. ( Beltrán Marqués, M; Cánovas Martínez, A; Delgado Cordón, F; Escrivá Aparisi, A; Ordovás Baines, JP, 1995) |
| "Approximately 30-40% of brain tumors patients who present with status epilepticus (SE) will not respond to typical therapy consisting of benzodiazepines and phenytoin (PHT), resulting in patients with refractory status epilepticus (RSE)." | 1.38 | Phenytoin, levetiracetam, and pregabalin in the acute management of refractory status epilepticus in patients with brain tumors. ( Doreswamy, M; Gingrich, KJ; Kolls, BJ; Swisher, CB; Vredenburgh, JJ, 2012) |
| " It has also been reported that pregabalin used with oxycodine reveals analgesic effect with smaller dosage than pregabalin alone." | 1.38 | [Case of acute exacerbation of neuropathic cancer pain rapidly relieved by simultaneous oral intake of immediate release oxycodone and pregabalin]. ( Baba, M; Gomwo, I, 2012) |
| "Acute hypotension was induced by intravenous infusion of sodium nitroprusside (SNP)." | 1.36 | [Changes of gamma-aminobutyric acid and glycine released in the medial vestibular nucleus following acute hypotension in conscious rats]. ( An, Y; Jin, QH; Jin, YZ; Li, XL, 2010) |
| "Acute hypotension was induced by infusing sodium nitroprusside (SNP) into the femoral vein." | 1.36 | Changes of some amino acid concentrations in the medial vestibular nucleus of conscious rats following acute hypotension. ( An, Y; Jin, QH; Jin, YZ; Kim, MS; Li, XL; Park, BR, 2010) |
| "Morphine pretreatment produced an increase in GABA levels and a decrease in glutamate levels in the first few minutes." | 1.35 | [Effect of a simple morphine system injection in some aminoacids in the anterior cingulate cortex during acute pain]. ( Hernández, L; Páez, X; Quiñones, B; Silva, E, 2008) |
| "Pretreatment with morphine suppressed the glutamate increase." | 1.35 | [Effect of a simple morphine system injection in some aminoacids in the anterior cingulate cortex during acute pain]. ( Hernández, L; Páez, X; Quiñones, B; Silva, E, 2008) |
| "Inhibition of herpetic allodynia by repeated oral administration of gabapentin (100 mg/kg) alleviated the overexpression of mRNA of pronociceptin, as well as the severity of postherpetic allodynia." | 1.35 | Nociceptin-receptor deficiency prevents postherpetic pain without effects on acute herpetic pain in mice. ( Andoh, T; Kuraishi, Y; Sasaki, A; Shiraki, K; Takahata, H; Takasaki, I; Takeshima, H, 2008) |
| "This report describes two cases of transverse myelitis caused by varicella zoster." | 1.34 | Transverse myelitis caused by varicella zoster: case reports. ( Köseolu, HK; Yücel, E; Yýlmaz, S, 2007) |
| "Transverse myelitis is a group of disorders characterized by focal inflammation of the spinal cord and results in loss of motor and sensory function below the level of injury." | 1.34 | Transverse myelitis caused by varicella zoster: case reports. ( Köseolu, HK; Yücel, E; Yýlmaz, S, 2007) |
| " Better effects could be achieved with earlier use of high dosage GABA or Na-DMPS." | 1.34 | The antidotal effects of high-dosage gamma-aminobutyric acid on acute tetramine poisoning as compared with sodium dimercaptopropane sulfonate. ( Han, J; Sun, P; Weng, Y, 2007) |
| "Acute chest pain is a common presentation in emergency." | 1.34 | Role of Stellate ganglion block in post CABG sympathetically mediated chest pain. ( Ahmed, I; Khan, MU, 2007) |
| "Seizures were detected by continuous electroencephalographic monitoring for 24 h following permanent middle cerebral artery occlusion (MCAo)." | 1.33 | Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats. ( Bautista, CC; Chen, RW; Dave, JR; Hartings, JA; Lu, XC; Tortella, FC; Williams, AJ, 2006) |
| "Acute seizures following brain injury have been associated with a worsening of patient outcome, but they are often undiagnosed and untreated when they occur without motor convulsions." | 1.33 | Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats. ( Bautista, CC; Chen, RW; Dave, JR; Hartings, JA; Lu, XC; Tortella, FC; Williams, AJ, 2006) |
| "The mean GABA level (nmol/mL) in the PTSD group (n = 55; M =." | 1.32 | Low posttrauma GABA plasma levels as a predictive factor in the development of acute posttraumatic stress disorder. ( Boss, V; Brunet, A; Cottencin, O; Devos, P; Ducrocq, F; Fontaine, M; Goudemand, M; Laffargue, P; Rascle, C; Thomas, P; Vaiva, G, 2004) |
| "Vigabatrin (VGB) is an irreversible inhibitor of gamma-aminobutyric acid (GABA) transaminase." | 1.32 | Acute vigabatrin retinotoxicity in albino rats depends on light but not GABA. ( Benz, AM; Ishikawa, M; Izumi, M; Izumi, Y; Thio, LL; Zorumski, CF, 2004) |
| " Five hundred micromolar GABA and 50 microM tiagabine were not toxic in the presence or absence of light." | 1.32 | Acute vigabatrin retinotoxicity in albino rats depends on light but not GABA. ( Benz, AM; Ishikawa, M; Izumi, M; Izumi, Y; Thio, LL; Zorumski, CF, 2004) |
| "Morphine sulfate has long been used for analgesia, but clinical applications can be limited by side effects, tolerance, and potential for addiction at therapeutic doses." | 1.32 | Intrathecal gabapentin enhances the analgesic effects of subtherapeutic dose morphine in a rat experimental pancreatitis model. ( Lu, Y; Smiley, MM; Vera-Portocarrero, LP; Westlund, KN; Zidan, A, 2004) |
| "Lactic acidosis has been implicated; however, increases in the excitotoxic amino acid glutamate, which correlate with increased neuronal damage, may be the cause for the increased damage seen in hyperglycemic stroke." | 1.31 | The effect of streptozotocin-induced diabetes on the release of excitotoxic and other amino acids from the ischemic rat cerebral cortex. ( Diaz, FG; Guyot, LL; O'Regan, MH; Phillis, JW; Song, D, 2001) |
| "Neurogenic inflammation is an inflammatory response of peripheral tissue to vasoactive substances released from sensory afferent terminals." | 1.31 | Activation of spinal ORL-1 receptors prevents acute cutaneous neurogenic inflammation: role of nociceptin-induced suppression of primary afferent depolarization. ( Dong, XW; Jia, YP; Priestley, T; Williams, PA, 2002) |
| "Acyclovir treatment healed all skin lesions by day 15 after inoculation." | 1.31 | Effects of analgesics on delayed postherpetic pain in mice. ( Andoh, T; Kuraishi, Y; Nojima, H; Sasaki, A; Shiraki, K; Takasaki, I, 2002) |
| "Pain was assessed prior to and during treatment at 1, 3 and 6 months with a 10 cm visual analogue scale which ranged from 0 ('no pain') to 10 ('worst pain imaginable'), or by the documentation of a verbal description of pain." | 1.31 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "Ocular ischemia was sustained for 30, 60 and 90 minutes." | 1.30 | Changes of GABA metabolic enzymes in acute retinal ischemia. ( Ishiguro, S; Kobayashi, N; Nishikawa, S; Tamai, M; Tomita, H, 1999) |
| "3." | 1.29 | Neuroprotection by propofol in acute mechanical injury: role of GABAergic inhibition. ( Hollrigel, GS; Soltesz, I; Toth, K, 1996) |
| "In Japan, acute encephalopathy with hepatic steatosis resembling Reye's syndrome has been reported to occur after treatment with the pantothenic acid antagonist, calcium hopantenate." | 1.28 | Acute encephalopathy with hepatic steatosis induced by pantothenic acid antagonist, calcium hopantenate, in dogs. ( Haratake, J; Horie, A; Ishii, N; Noda, S; Sasaki, A; Umezaki, H, 1991) |
| "Muscimol was chronically administrated to the third ventricle of thalamic pigeons by means of osmotic minipumps at the rate of 0." | 1.27 | Effects of chronic intracerebroventricular GABAergic treatment on basal and chronic or acute stress-induced adrenocortical activities in the thalamic pigeon. ( Baylé, JD; Ramade, F, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (15.58) | 18.7374 |
| 1990's | 26 (16.88) | 18.2507 |
| 2000's | 65 (42.21) | 29.6817 |
| 2010's | 36 (23.38) | 24.3611 |
| 2020's | 3 (1.95) | 2.80 |
| Authors | Studies |
|---|---|
| Kalantari, S | 1 |
| Chashmniam, S | 1 |
| Nafar, M | 1 |
| Samavat, S | 1 |
| Rezaie, D | 1 |
| Dalili, N | 1 |
| Sun, T | 1 |
| Luo, L | 1 |
| Tian, QQ | 1 |
| Wang, WJ | 1 |
| Liu, QQ | 1 |
| Yang, L | 2 |
| Zhang, K | 1 |
| Zhang, W | 1 |
| Zhao, MG | 1 |
| Yang, Q | 1 |
| Zhang, T | 1 |
| Yu, F | 1 |
| Xu, H | 1 |
| Chen, M | 1 |
| Chen, X | 1 |
| Guo, L | 1 |
| Zhou, C | 1 |
| Xu, Y | 2 |
| Wang, F | 1 |
| Yu, J | 1 |
| Wu, B | 1 |
| Wang, S | 1 |
| Sui, S | 1 |
| Liu, Z | 1 |
| Peng, C | 1 |
| Liu, J | 2 |
| Luo, D | 1 |
| Fan, X | 1 |
| Liu, C | 1 |
| Lu, WY | 1 |
| Kakall, ZM | 1 |
| Pilowsky, PM | 1 |
| Farnham, MMJ | 1 |
| Simancas-Racines, D | 1 |
| Arevalo-Rodriguez, I | 1 |
| Osorio, D | 1 |
| Franco, JV | 1 |
| Hidalgo, R | 1 |
| Zhang, J | 2 |
| Wang, LN | 1 |
| Rohman, L | 1 |
| Hebron, A | 1 |
| Zhao, M | 1 |
| Nakamura, S | 1 |
| Miyake, T | 1 |
| So, K | 1 |
| Shirakawa, H | 1 |
| Tokuyama, S | 1 |
| Narita, M | 1 |
| Nakagawa, T | 1 |
| Kaneko, S | 1 |
| Dias, JM | 1 |
| de Brito, TV | 1 |
| de Aguiar Magalhães, D | 1 |
| da Silva Santos, PW | 1 |
| Batista, JA | 1 |
| do Nascimento Dias, EG | 1 |
| de Barros Fernandes, H | 1 |
| Damasceno, SR | 1 |
| Silva, RO | 1 |
| Aragão, KS | 1 |
| Souza, MH | 1 |
| Medeiros, JV | 1 |
| Barbosa, AL | 1 |
| Drouet, JB | 1 |
| Fauvelle, F | 1 |
| Maunoir-Regimbal, S | 1 |
| Fidier, N | 1 |
| Maury, R | 1 |
| Peinnequin, A | 1 |
| Denis, J | 1 |
| Buguet, A | 1 |
| Canini, F | 1 |
| MacKenzie, G | 1 |
| Maguire, J | 1 |
| Sierra-Paredes, G | 1 |
| Loureiro, AI | 1 |
| Wright, LC | 1 |
| Sierra-Marcuño, G | 1 |
| Soares-da-Silva, P | 1 |
| Matsumura, S | 1 |
| Taniguchi, W | 1 |
| Nishida, K | 1 |
| Nakatsuka, T | 1 |
| Ito, S | 1 |
| Chutko, LS | 1 |
| Surushkina, SIu | 1 |
| Iakovenko, EA | 1 |
| Nikishena, IS | 1 |
| Anisimova, TI | 1 |
| Bondarchuk, IuL | 1 |
| Nottage, KA | 1 |
| Hankins, JS | 1 |
| Faughnan, LG | 1 |
| James, DM | 1 |
| Richardson, J | 1 |
| Christensen, R | 1 |
| Kang, G | 1 |
| Smeltzer, M | 1 |
| Cancio, MI | 1 |
| Wang, WC | 1 |
| Anghelescu, DL | 1 |
| Houtepen, LC | 1 |
| Schür, RR | 1 |
| Wijnen, JP | 1 |
| Boer, VO | 1 |
| Boks, MP | 1 |
| Kahn, RS | 1 |
| Joëls, M | 1 |
| Klomp, DW | 1 |
| Vinkers, CH | 1 |
| Einarsdottir, S | 1 |
| Björnsson, E | 1 |
| Hetzler, BE | 1 |
| Ondracek, JM | 1 |
| Becker, EA | 1 |
| Siddiqui, A | 1 |
| Suresh, S | 1 |
| Dworkin, RH | 1 |
| Barbano, RL | 1 |
| Tyring, SK | 1 |
| Betts, RF | 1 |
| McDermott, MP | 1 |
| Pennella-Vaughan, J | 1 |
| Bennett, GJ | 1 |
| Berber, E | 1 |
| Gnann, JW | 1 |
| Irvine, C | 1 |
| Kamp, C | 1 |
| Kieburtz, K | 1 |
| Max, MB | 1 |
| Schmader, KE | 1 |
| Silva, E | 1 |
| Quiñones, B | 1 |
| Páez, X | 1 |
| Hernández, L | 1 |
| Bodenmann, P | 1 |
| Pasche, O | 1 |
| Nanchen, D | 1 |
| Jaunin-Stalder, N | 1 |
| Marguerat, I | 1 |
| Chapuis, T | 1 |
| de Bosset, V | 1 |
| Cornuz, J | 1 |
| Clarke, H | 1 |
| Pereira, S | 1 |
| Kennedy, D | 1 |
| Andrion, J | 1 |
| Mitsakakis, N | 1 |
| Gollish, J | 1 |
| Katz, J | 1 |
| Kay, J | 1 |
| Moore, RA | 6 |
| Straube, S | 2 |
| Wiffen, PJ | 5 |
| Derry, S | 3 |
| McQuay, HJ | 6 |
| Fleckenstein, J | 1 |
| Kramer, S | 1 |
| Hoffrogge, P | 1 |
| Thoma, S | 1 |
| Lang, PM | 1 |
| Lehmeyer, L | 1 |
| Schober, GM | 1 |
| Pfab, F | 1 |
| Ring, J | 1 |
| Weisenseel, P | 1 |
| Schotten, KJ | 1 |
| Mansmann, U | 1 |
| Irnich, D | 1 |
| Blanc, F | 1 |
| Ruppert, E | 1 |
| Kleitz, C | 1 |
| Valenti, MP | 1 |
| Cretin, B | 1 |
| Humbel, RL | 1 |
| Honnorat, J | 1 |
| Namer, IJ | 1 |
| Hirsch, E | 1 |
| Manning, L | 1 |
| de Seze, J | 1 |
| Sen, H | 2 |
| Sizlan, A | 1 |
| Yanarates, O | 1 |
| Emirkadi, H | 1 |
| Ozkan, S | 1 |
| Dagli, G | 1 |
| Turan, A | 3 |
| Kaufman, KR | 1 |
| Tanchuck, MA | 1 |
| Strong, MN | 1 |
| Finn, DA | 1 |
| Collins, S | 2 |
| Carroll, D | 2 |
| Jadad, A | 2 |
| Li, XL | 2 |
| An, Y | 2 |
| Jin, QH | 2 |
| Jin, YZ | 2 |
| Kim, MS | 1 |
| Park, BR | 1 |
| Rusy, LM | 1 |
| Hainsworth, KR | 1 |
| Nelson, TJ | 1 |
| Czarnecki, ML | 1 |
| Tassone, JC | 1 |
| Thometz, JG | 1 |
| Lyon, RM | 1 |
| Berens, RJ | 1 |
| Weisman, SJ | 1 |
| Amr, YM | 1 |
| Yousef, AA | 1 |
| Krcevski Skvarc, N | 1 |
| Kamenik, M | 1 |
| Hasler, G | 1 |
| van der Veen, JW | 1 |
| Grillon, C | 1 |
| Drevets, WC | 1 |
| Shen, J | 1 |
| Durkin, B | 1 |
| Page, C | 1 |
| Glass, P | 1 |
| Ucak, A | 1 |
| Onan, B | 1 |
| Selcuk, I | 1 |
| Yilmaz, AT | 1 |
| Ho, KY | 2 |
| Wang, Y | 1 |
| Edwards, J | 1 |
| Lapolla, W | 1 |
| Digiorgio, C | 1 |
| Haitz, K | 1 |
| Magel, G | 1 |
| Mendoza, N | 1 |
| Grady, J | 1 |
| Lu, W | 1 |
| Tyring, S | 1 |
| Sahgal, N | 1 |
| Banerjee, A | 1 |
| Igelström, KM | 1 |
| Shirley, CH | 1 |
| Heyward, PM | 1 |
| Swisher, CB | 1 |
| Doreswamy, M | 1 |
| Gingrich, KJ | 1 |
| Vredenburgh, JJ | 1 |
| Kolls, BJ | 1 |
| Komoly, S | 1 |
| Derks, NM | 1 |
| Pintér, O | 1 |
| Zuure, W | 1 |
| Ledent, C | 1 |
| Watanabe, M | 1 |
| Molnár, CS | 1 |
| Wei, Y | 1 |
| Roubos, EW | 1 |
| Wu, S | 1 |
| Hrabovszky, E | 1 |
| Zelena, D | 1 |
| Kozicz, T | 1 |
| Astaneh, AN | 1 |
| Rezaei, O | 1 |
| Baba, M | 1 |
| Gomwo, I | 1 |
| Handreck, A | 1 |
| Backofen-Wehrhahn, B | 1 |
| Bröer, S | 1 |
| Löscher, W | 1 |
| Gernert, M | 1 |
| Garcia-Cairasco, N | 1 |
| Laughlin, TM | 1 |
| Tram, KV | 1 |
| Wilcox, GL | 1 |
| Birnbaum, AK | 1 |
| Matsko, MA | 1 |
| Ivanova, NE | 1 |
| Heinz, A | 1 |
| Schäfer, M | 1 |
| Higley, JD | 1 |
| Krystal, JH | 1 |
| Goldman, D | 1 |
| Vaiva, G | 1 |
| Thomas, P | 1 |
| Ducrocq, F | 1 |
| Fontaine, M | 1 |
| Boss, V | 1 |
| Devos, P | 1 |
| Rascle, C | 1 |
| Cottencin, O | 1 |
| Brunet, A | 1 |
| Laffargue, P | 1 |
| Goudemand, M | 1 |
| Bureau, C | 1 |
| Poirson, H | 1 |
| Péron, JM | 1 |
| Vinel, JP | 1 |
| Dost, R | 1 |
| Rostock, A | 1 |
| Rundfeldt, C | 1 |
| Karamanlioğlu, B | 1 |
| Memiş, D | 1 |
| Hamamcioglu, MK | 1 |
| Tükenmez, B | 1 |
| Pamukçu, Z | 1 |
| Kurt, I | 1 |
| French, JA | 1 |
| Kanner, AM | 1 |
| Bautista, J | 1 |
| Abou-Khalil, B | 1 |
| Browne, T | 1 |
| Harden, CL | 1 |
| Theodore, WH | 1 |
| Bazil, C | 1 |
| Stern, J | 1 |
| Schachter, SC | 1 |
| Bergen, D | 1 |
| Hirtz, D | 1 |
| Montouris, GD | 1 |
| Nespeca, M | 1 |
| Gidal, B | 1 |
| Marks, WJ | 1 |
| Turk, WR | 1 |
| Fischer, JH | 1 |
| Bourgeois, B | 1 |
| Wilner, A | 1 |
| Faught, RE | 1 |
| Sachdeo, RC | 1 |
| Beydoun, A | 1 |
| Glauser, TA | 1 |
| Iyengar, S | 1 |
| Webster, AA | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Protective Role of Preoperative Stimulation of the Distal Limb of the Ileostomy Loop With GABA Before Ileostomy Closure[NCT05905393] | Phase 3 | 80 participants (Anticipated) | Interventional | 2023-06-30 | Not yet recruiting | ||
| Effect of Early Use of Oxycodone During the Acute Phase of Herpes Zoster on Preventing Postherpetic Neuralgia[NCT03120962] | 140 participants (Anticipated) | Interventional | 2017-05-31 | Not yet recruiting | |||
| Phenomics and Genomics of Clinically Relevant Chronic Postsurgical Pain: A Multicenter Prospective Study[NCT04798573] | 10,000 participants (Anticipated) | Observational | 2012-08-03 | Active, not recruiting | |||
| Pre-Emptive Analgesia in Ano-Rectal Surgery[NCT02402543] | 90 participants (Actual) | Interventional | 2014-06-30 | Completed | |||
| Use of Single Dose Pre-Operative Pregabalin for Post-Operative Analgesia in Bilateral Head and Neck Cancer Surgery: A Randomized, Double-Blinded, Placebo-Controlled Trial[NCT03714867] | Phase 4 | 0 participants (Actual) | Interventional | 2019-03-22 | Withdrawn (stopped due to Inability to recruit patients) | ||
| Cannabidiol for Fibromyalgia -The CANNFIB Trial Protocol for a Randomized, Double-blind, Placebo-controlled, Parallel-group, Single-center Trial[NCT04729179] | Phase 3 | 200 participants (Anticipated) | Interventional | 2021-03-01 | Recruiting | ||
| Analgetic Effectiveness of Acupuncture When Compared to a Standardised Analgesic Regimen in the Treatment of Herpes Zoster Neuralgia[NCT00885586] | Phase 4 | 68 participants (Actual) | Interventional | 2008-11-30 | Completed | ||
| The Efficacy and Safety of Intradermal Acupuncture for Acute Herpes Zoster: Study Protocol for a Randomized Controlled Trial[NCT05348382] | 72 participants (Anticipated) | Interventional | 2022-07-04 | Recruiting | |||
| The Effect of Intravenous Infusions of Lidocaine and Magnesium Versus Lidocaine and Ketamine Versus Lidocaine Alone on Recovery Profile and Postoperative Pain After Elective Gynecological Surgery[NCT04622904] | 90 participants (Anticipated) | Interventional | 2020-11-14 | Recruiting | |||
| Effect of Ultra-low Dose Naloxone on Remifentanil-Induced Hyperalgesia[NCT03066739] | Phase 2 | 105 participants (Anticipated) | Interventional | 2023-02-25 | Recruiting | ||
| Use of Gabapentin as Preanesthetic Medication in Oncologic Children Undergoing in Fast Procedures With Sevofluran[NCT03681574] | Phase 4 | 135 participants (Actual) | Interventional | 2017-07-01 | Completed | ||
| Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients[NCT02558010] | Phase 3 | 58 participants (Actual) | Interventional | 2016-02-01 | Completed | ||
| Placebo Controlled, Randomized,Gabapentin as Adjuvant for Postoperative Pain in Pediatric Orthopedic Surgery[NCT03005483] | Phase 4 | 40 participants (Actual) | Interventional | 2014-01-31 | Completed | ||
| Gabapentin Regimens and Their Effects on Opioid Consumption[NCT03334903] | Phase 4 | 77 participants (Actual) | Interventional | 2018-05-15 | Completed | ||
| Pain Control in Pediatric Posterior Spine Fusion Patients: The Effect of Gabapentin on Post-operative Opioid Use and Patient Satisfaction[NCT01977937] | Phase 4 | 55 participants (Actual) | Interventional | 2013-11-30 | Completed | ||
| Efficacy of Gabapentin as Adjuvant for Postoperative Pain in Pediatric Thoracic Surgery - a Randomized Quadruple Blind Study[NCT03393702] | Phase 4 | 104 participants (Actual) | Interventional | 2017-05-09 | Completed | ||
| Single Dose Preoperative Gabapentin Use in Minimally Invasive Hysterectomy for Acute Pain Management[NCT02703259] | Phase 4 | 137 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
| The Effect of Lidocaine to Prevent the Development of Chronic Post-Surgical Pain[NCT01619852] | 148 participants (Actual) | Interventional | 2012-06-30 | Completed | |||
| [NCT01250561] | 133 participants (Actual) | Interventional | 2002-02-28 | Completed | |||
| Effects of Pre-operative Oral Pregabalin on Post Operative Morphine Consumption After Abdominal Hysterectomy With/Without Salpingo-oophorectomy Under Spinal Anesthesia With Intrathecal Morphine[NCT02285010] | Phase 4 | 125 participants (Actual) | Interventional | 2014-11-30 | Completed | ||
| Comparison of Oral Gabapentin and Pregabalin in Postoperative Pain Control After Photorefractive Keratectomy: a Prospective, Randomized Study.[NCT00954187] | 8 participants (Actual) | Interventional | 2009-11-30 | Terminated (stopped due to PI left institution) | |||
| Randomized Controlled Pilot Trial of Adjunct Group Acupuncture vs Usual Care Among Patients With Painful Diabetic Neuropathy[NCT02104466] | 40 participants (Actual) | Interventional | 2015-03-31 | Completed | |||
| Effect of a Multimodal Pain Regimen on Pain Control, Patient Satisfaction and Narcotic Use in Orthopaedic Trauma Patients[NCT02160301] | Phase 4 | 0 participants (Actual) | Interventional | 2017-11-30 | Withdrawn (stopped due to Insufficient infrastructure/funding for enrollment) | ||
| The Effect of Gabapentin on Acute Pain and PONV in Bariatric Surgical Patients[NCT00886236] | 62 participants (Actual) | Interventional | 2008-02-29 | Completed | |||
| Comparison of Oral Lamotrigine Versus Pregabalin for Control of Acute and Chronic Pain Following Modified Radical Mastectomy: Controlled Double-blind Study[NCT03419949] | 0 participants | Expanded Access | Available | ||||
| Pilot Evaluation of Levetiracetam (Keppra® (Registered Trademark)) in Bipolar Illness[NCT00015769] | Phase 2 | 30 participants | Interventional | 2001-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Total amount of opioids consumed during the first 72 hours after surgery. (NCT02558010)
Timeframe: 72 hours
| Intervention | mg/kg (Median) |
|---|---|
| Methadone Group | 0.267 |
| Control Group | 0.340 |
Surgical site pain. Scale 0-10, with 0 best and 10 worst (NCT03334903)
Timeframe: 2-3 months after surgery (at 2nd postoperative appointment)
| Intervention | score on 10-point scale (Mean) |
|---|---|
| Standard of Care | 2.26 |
| Postoperative Gabapentin Regimen | 2.46 |
Surgical site pain. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
| Intervention | score on a 10-point scale (Mean) |
|---|---|
| Standard of Care | 3.84 |
| Postoperative Gabapentin Regimen | 3.54 |
Sleep quality. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
| Intervention | score on a 10-point scale (Mean) |
|---|---|
| Standard of Care | 5.73 |
| Postoperative Gabapentin Regimen | 6.38 |
Nausea. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
| Intervention | score on a 10-point scale (Mean) |
|---|---|
| Standard of Care | 0.36 |
| Postoperative Gabapentin Regimen | 0.17 |
Satisfaction. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
| Intervention | score on a 10-point scale (Mean) |
|---|---|
| Standard of Care | 7.83 |
| Postoperative Gabapentin Regimen | 8.48 |
Number of days until patients are finished consuming opioid medications after discharge. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
| Intervention | days (Mean) |
|---|---|
| Standard of Care | 14.8 |
| Postoperative Gabapentin Regimen | 18.7 |
Mean opioid consumption, measured in mg of morphine equivalents. (NCT03334903)
Timeframe: 2-3 months following surgery (total amount measured at second postoperative appointment; means assessed afterwards).
| Intervention | morphine equivalents (Mean) |
|---|---|
| Standard of Care | 287.0 |
| Postoperative Gabapentin Regimen | 281.1 |
"Patients will rate their pain using the Visual Analog Pain Scale (VAS). The VAS is a 10 cm line with anchors of no pain and worst pain imaginable. Patients rate their pain by marking on the 10 cm line where they feel their pain is at the time. The mark is then measured according to where it is along the 10 cm line and reported (range is 0.0 at the no pain end on the left up to 10.0 at the worst pain imaginable on the right). Lower pain scores on the VAS scale are considered a better outcome. The numbers seen in the outcome measure data table below represent an average of the total postoperative VAS scores recorded for each patient from each arm for the duration of their hospital stay." (NCT01977937)
Timeframe: five days
| Intervention | pain score on a scale (Mean) |
|---|---|
| Gabapentin | 2.46 |
| Simple Syrup | 3.46 |
Total the amount of Hydromorphone and Oxycodone used in milligrams per kilogram in each patient post-operatively, convert this amount to morphine equivalents, and determine if there is a significant difference between the Gabapentin versus Placebo group. (NCT01977937)
Timeframe: Five Days
| Intervention | morphine equivalents mg per kg (Mean) |
|---|---|
| Gabapentin | 3.58 |
| Simple Syrup | 5.33 |
Assessment of the amount of narcotic use postoperatively at 2 weeks. will use opioid equivalence table to convert all narcotic use to oxycodone equivalents (NCT02703259)
Timeframe: 2 weeks
| Intervention | morphine milligram equivalents (Mean) |
|---|---|
| Gabapentin | 167.2 |
| Control | 187.3 |
Assessment of the amount of narcotic use postoperatively at 24 hours. will use opioid equivalence table to convert all narcotic use to oxycodone equivalents (NCT02703259)
Timeframe: 24 hours
| Intervention | morphine milligram equivalents (Mean) |
|---|---|
| Gabapentin | 158.8 |
| Control | 175.0 |
"Assessment of the subject pain score postoperatively at 2 weeks. will use a numeric analog scale from 0-10.~The pain scale ranging from 0-10 with 0 representing No Pain and 10 representing the Worst Pain Possible" (NCT02703259)
Timeframe: 2 weeks
| Intervention | score on a scale (Mean) |
|---|---|
| Gabapentin | 1.3 |
| Control | 1.4 |
Pain score assesses patient subjective pain via patient reported numeric analogue scale, range 0-10 with 0 being no pain and 10 being severe pain. (NCT02703259)
Timeframe: 24 hours
| Intervention | score on a scale (Mean) |
|---|---|
| Gabapentin | 3.4 |
| Control | 3.4 |
Will assess for known symptoms of gabapentin postoperatively at 2 weeks. We will survey subjects regarding their experience of the following symptoms: dizziness/drowsiness, fatigue, loss of balance, blurry vision, tremulousness, swelling, nausea, vomiting, diarrhea, and allergic reaction (NCT02703259)
Timeframe: 2 weeks
| Intervention | Participants (Count of Participants) | ||||||
|---|---|---|---|---|---|---|---|
| Dizziness | Blurred vision | Somnolence | Difficulty walking | Tremulousness | Nausea | Vomiting | |
| Control | 8 | 3 | 21 | 5 | 2 | 7 | 1 |
| Gabapentin | 12 | 4 | 18 | 5 | 4 | 12 | 0 |
Will assess for known symptoms of gabapentin postoperatively at 24 hours. We will survey subjects regarding their experience of the following symptoms: dizziness/drowsiness, fatigue, loss of balance, blurry vision, tremulousness, swelling, nausea, vomiting, diarrhea, and allergic reaction (NCT02703259)
Timeframe: 24 hours
| Intervention | Participants (Count of Participants) | ||||||
|---|---|---|---|---|---|---|---|
| Dizziness | Blurred Vision | Somnolence | Difficulty walking | Tremulousness | Nausea | Vomiting | |
| Control | 8 | 4 | 23 | 11 | 6 | 25 | 15 |
| Gabapentin | 17 | 7 | 20 | 13 | 11 | 24 | 9 |
The participants development of chronic persistent pain 3 months after surgery as determined by character severity (yes/no). (NCT01619852)
Timeframe: 3 months
| Intervention | participants (Number) |
|---|---|
| Group L | 2 |
| .9% Normal Saline Placebo | 6 |
The amount of opioid analgesics consumed was converted to an equivalent dose of intravenous morphine. (NCT01619852)
Timeframe: 24 hours
| Intervention | equivalent dose of intravenous morphine (Median) |
|---|---|
| Group L | 34 |
| .9% Normal Saline Placebo | 39 |
Postoperative pain within the first 24 hours. Area under the numeric rating scale for pain versus time curve during the first 24 hours after surgery (score * hr). Numeric rating scale for pain on a scale of 0-10 (0 is no pain and 10 is high pain) versus time curve during the first 24 hours ( score * hr). The pain scores were collected upon arrival to recovery area, 30 minutes, 1 hour and every 6 hours up to 24 hours following the procedure. Minimum score is 60, Maximum score is 170. A higher value indicates more pain. (NCT01619852)
Timeframe: 24 hours
| Intervention | score on a scale (Median) |
|---|---|
| Group L | 116 |
| .9% Normal Saline Placebo | 119 |
Quality of recovery (QoR-40 instrument) is a 40-item questionnaire that provides a global score and sub-scores across five dimensions: patient support, comfort, emotions, physical independence, and pain. Score range: 40 to 200. A score of 40 demonstrates poor recovery and a maximum score of 200 represents good recovery. The higher the score the better recovery after surgery. (NCT01619852)
Timeframe: 24 hours post operative
| Intervention | units on a scale (Median) |
|---|---|
| Lidocaine (Group L) | 158 |
| .9% Normal Saline Placebo | 169 |
The development of chronic pain 3 months after surgery determined by the Leads Assessment of Neuropathic Symptoms and Signs (LANSS) scale, a valid 7-item tool for identifying patients whose pain is dominated by neuropathic mechanisms. Each item is a binary response (yes or no) to the presence of symptoms (5 items) or clinical signs (2 items), range 0-24 points. A score ≥ 12, neuropathic mechanisms are likely to be contributing to the patient's pain. A score < 12 is unlikely to be contributing. McGill questionnaire (Sensory domain) - 11 descriptors rated on an intensity scale as 0=none, 1=mild, 2=moderate, 3=severe. The higher the score, greater the pain (range 0-33). McGill questionnaire (Motivational-affective) 4 affect descriptors rated on an intensity scale as 0=none, 1=mild, 2=moderate, 3=severe.The higher the score the greater the pain (range 0-12) Brief pain inventory - pain severity (0, no pain, 10 excruciating pain); Greater the score; greater the pain (range 0-10). (NCT01619852)
Timeframe: 3 months
| Intervention | units on a scale (Median) | |||
|---|---|---|---|---|
| S-LANNS | McGill Questionaire-Sensory Discrimation | McGill Questionaire-Motivational-affective | Brief Pain Inventory | |
| .9% Normal Saline Placebo | 3 | 3 | 0 | 1 |
| Group L | 3 | 4 | 0 | 1 |
Time to first analgesia is recorded from IV PCA. (NCT02285010)
Timeframe: 24 hours
| Intervention | hour (Median) |
|---|---|
| Placebo | 4.6 |
| Pregabalin | 7.7 |
"Pain score is evaluated by nurses using Numerical Rating Scale (NRS)~Minimum score 0 (no pain), Maximum score 10 (worst imaginable pain), lower scores mean a better outcome" (NCT02285010)
Timeframe: 24 hours
| Intervention | score on a scale (Median) | |
|---|---|---|
| At rest | At movement | |
| Placebo | 2 | 4 |
| Pregabalin | 2 | 4 |
Cumulative morphine consumption in the first 24 hours is recorded from IV PCA (NCT02285010)
Timeframe: 6, 12, and 24 hours after operation
| Intervention | mg (Median) | ||
|---|---|---|---|
| Morphine consumption 6 hr | Morphine consumption 12 hr | Morphine consumption 24 hr | |
| Placebo | 1 | 1 | 4 |
| Pregabalin | 0 | 1 | 5 |
Measure sedation score by evaluate and observe; measure pruritus, PONV, dizziness, visual disturbance using questionnaire (NCT02285010)
Timeframe: 24 hours
| Intervention | Participants (Count of Participants) | |||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pruritus72177998 | Pruritus72177999 | Nausea72177998 | Nausea72177999 | Vomiting72177998 | Vomiting72177999 | Dizziness72177998 | Dizziness72177999 | Visual disturbance72177998 | Visual disturbance72177999 | |||||||||||||||||||||||||||||||
| No | Mild | Moderate | Severe | |||||||||||||||||||||||||||||||||||||
| Pregabalin | 17 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 35 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 31 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 15 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 10 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 1 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 3 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 18 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 23 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 24 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 21 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 16 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 31 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 38 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 10 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 9 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 12 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 8 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 5 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 6 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 14 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 39 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 9 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 7 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 1 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 51 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 45 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 7 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 16 | |||||||||||||||||||||||||||||||||||||||
| Placebo | 0 | |||||||||||||||||||||||||||||||||||||||
| Pregabalin | 0 | |||||||||||||||||||||||||||||||||||||||
(NCT00886236)
Timeframe: 48 hours
| Intervention | % oxygen saturation (Mean) |
|---|---|
| 1 Preoperative Gabapentin Liquid | 93 |
| 2 Preoperative and Postoperative Gabapentin Liquid | 94 |
| 3 Preoperative and Postoperative Placebo Liquid | 95 |
The amount of intraoperative and postoperative opioids used will be collected and analyzed for the three different arms. (NCT00886236)
Timeframe: 120 hours
| Intervention | ml (Mean) |
|---|---|
| 1 Preoperative Gabapentin Liquid | 11.035 |
| 2 Preoperative and Postoperative Gabapentin Liquid | 8.7 |
| 3 Preoperative and Postoperative Placebo Liquid | 12.4 |
(NCT00886236)
Timeframe: 120 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| 1 Preoperative Gabapentin Liquid | 12 |
| 2 Preoperative and Postoperative Gabapentin Liquid | 11 |
| 3 Preoperative and Postoperative Placebo Liquid | 12 |
31 reviews available for gamma-aminobutyric acid and Acute Disease
| Article | Year |
|---|---|
Interventions for treating acute high altitude illness.
Topics: Acetazolamide; Acute Disease; Adolescent; Adult; Altitude Sickness; Amines; Anticonvulsants; Atmosph | 2018 |
Gamma aminobutyric acid (GABA) receptor agonists for acute stroke.
Topics: Acute Disease; Chlormethiazole; Diazepam; Disorders of Excessive Somnolence; GABA Agonists; gamma-Am | 2018 |
[Innovations in ambulatory care].
Topics: Acute Disease; Age Factors; Aged, 80 and over; Algorithms; Ambulatory Care; Analgesics; Angiotensin- | 2009 |
Pregabalin for acute and chronic pain in adults.
Topics: Acute Disease; Adult; Analgesics; Chronic Disease; Diabetic Neuropathies; Fibromyalgia; gamma-Aminob | 2009 |
Pregabalin for acute and chronic pain in adults.
Topics: Acute Disease; Adult; Analgesics; Chronic Disease; Diabetic Neuropathies; Fibromyalgia; gamma-Aminob | 2009 |
Pregabalin for acute and chronic pain in adults.
Topics: Acute Disease; Adult; Analgesics; Chronic Disease; Diabetic Neuropathies; Fibromyalgia; gamma-Aminob | 2009 |
Pregabalin for acute and chronic pain in adults.
Topics: Acute Disease; Adult; Analgesics; Chronic Disease; Diabetic Neuropathies; Fibromyalgia; gamma-Aminob | 2009 |
WITHDRAWN. Anticonvulsant drugs for acute and chronic pain.
Topics: Acute Disease; Amines; Anticonvulsants; Chronic Disease; Controlled Clinical Trials as Topic; Cycloh | 2010 |
Single dose oral gabapentin for established acute postoperative pain in adults.
Topics: Acute Disease; Administration, Oral; Adult; Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapen | 2010 |
Pregabalin for the treatment of postsurgical pain.
Topics: Acute Disease; Analgesics; Analgesics, Opioid; Chronic Disease; Dose-Response Relationship, Drug; ga | 2010 |
Efficacy of pregabalin in acute postoperative pain: a meta-analysis.
Topics: Acute Disease; Analgesics, Non-Narcotic; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; | 2011 |
WITHDRAWN: Gabapentin for acute and chronic pain.
Topics: Acute Disease; Amines; Analgesics; Anticonvulsants; Chronic Disease; Cyclohexanecarboxylic Acids; ga | 2011 |
A critical review on the participation of inferior colliculus in acoustic-motor and acoustic-limbic networks involved in the expression of acute and kindled audiogenic seizures.
Topics: Acoustic Stimulation; Acute Disease; Animals; Bicuculline; Epilepsy, Reflex; gamma-Aminobutyric Acid | 2002 |
Neurobiological correlates of the disposition and maintenance of alcoholism.
Topics: Acute Disease; Alcoholism; Brain; Chronic Disease; Dopamine; Drug Tolerance; Ethanol; gamma-Aminobut | 2003 |
Efficacy and tolerability of the new antiepileptic drugs I: treatment of new onset epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epileps
Topics: Acetates; Acute Disease; Adolescent; Adult; Amines; Anticonvulsants; Carbamazepine; Child; Controlle | 2004 |
Reversal or reduction of glutamate and GABA transport in CNS pathology and therapy.
Topics: Acute Disease; Animals; Central Nervous System Diseases; Chronic Disease; gamma-Aminobutyric Acid; G | 2004 |
Lamotrigine and antiepileptic drugs as mood stabilizers in bipolar disorder.
Topics: Acute Disease; Amines; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine; Cyclohexa | 2005 |
Anticonvulsant drugs for acute and chronic pain.
Topics: Acute Disease; Amines; Anticonvulsants; Chronic Disease; Controlled Clinical Trials as Topic; Cycloh | 2005 |
Gabapentin for acute and chronic pain.
Topics: Acute Disease; Amines; Analgesics; Anticonvulsants; Chronic Disease; Cyclohexanecarboxylic Acids; Ga | 2005 |
Gabapentin and postoperative pain--a systematic review of randomized controlled trials.
Topics: Acute Disease; Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2006 |
Gabapentin and postoperative pain--a systematic review of randomized controlled trials.
Topics: Acute Disease; Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2006 |
Gabapentin and postoperative pain--a systematic review of randomized controlled trials.
Topics: Acute Disease; Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2006 |
Gabapentin and postoperative pain--a systematic review of randomized controlled trials.
Topics: Acute Disease; Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2006 |
Gabapentin and postoperative pain--a systematic review of randomized controlled trials.
Topics: Acute Disease; Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2006 |
Gabapentin and postoperative pain--a systematic review of randomized controlled trials.
Topics: Acute Disease; Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2006 |
Gabapentin and postoperative pain--a systematic review of randomized controlled trials.
Topics: Acute Disease; Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2006 |
Gabapentin and postoperative pain--a systematic review of randomized controlled trials.
Topics: Acute Disease; Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2006 |
Gabapentin and postoperative pain--a systematic review of randomized controlled trials.
Topics: Acute Disease; Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2006 |
GABAergic drugs for the treatment of migraine.
Topics: Acute Disease; Amines; Animals; Cyclohexanecarboxylic Acids; Fructose; GABA Agents; GABA Antagonists | 2007 |
Pain management in the traumatic amputee.
Topics: Acute Disease; Afghanistan; Amines; Amputation, Traumatic; Analgesia; Analgesics; Benchmarking; Caus | 2008 |
'It's not over when it's over': persistent neurobiological abnormalities in recovered depressed patients.
Topics: Acute Disease; Depressive Disorder; Dexamethasone; Electroconvulsive Therapy; gamma-Aminobutyric Aci | 2008 |
Acute pain: combination treatments and how we measure their efficacy.
Topics: Acute Disease; Amines; Analgesics, Non-Narcotic; Cyclohexanecarboxylic Acids; Drug Administration Sc | 2008 |
GABA and acute psychoses.
Topics: Acute Disease; Animals; Brain; Cats; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; Limbi | 1982 |
Neurologic manifestations of acute porphyria.
Topics: Acute Disease; Aminolevulinic Acid; Animals; Central Nervous System; Depression; Electrophysiology; | 1982 |
Vigabatrin-associated reversible acute psychosis in a child.
Topics: 4-Aminobutyrate Transaminase; Acute Disease; Anticonvulsants; Child; Clinical Trials as Topic; Enzym | 1995 |
Aggravation of generalized epilepsies.
Topics: Acute Disease; Anticonvulsants; Carbamazepine; Epilepsy, Generalized; gamma-Aminobutyric Acid; Human | 1998 |
Aggravation of focal epileptic seizures by antiepileptic drugs.
Topics: Acetates; Acute Disease; Adult; Amines; Anticonvulsants; Clinical Trials as Topic; Cyclohexanecarbox | 1998 |
GABA potentiation: a logical pharmacological approach for the treatment of acute ischaemic stroke.
Topics: Acute Disease; Animals; Brain; Brain Ischemia; Chlormethiazole; GABA Agonists; gamma-Aminobutyric Ac | 2000 |
An overview of acute stroke therapy: past, present, and future.
Topics: Acute Disease; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antibodies; Brain Ischemia; | 2000 |
The evolving role of topiramate among other mood stabilizers in the management of bipolar disorder.
Topics: Acetates; Acute Disease; Amines; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine; | 2001 |
The pharmacology of choreatic movement disorders.
Topics: Acetylcholine; Acute Disease; Amphetamine; Chorea; Dopamine; gamma-Aminobutyric Acid; Hepatolenticul | 1976 |
[Clinical and biochemical studies in a case of acute encephalopathy associated with calcium hopanthenate administration].
Topics: Acute Disease; Brain Diseases, Metabolic; Child, Preschool; Decanoic Acids; gamma-Aminobutyric Acid; | 1990 |
17 trials available for gamma-aminobutyric acid and Acute Disease
| Article | Year |
|---|---|
Addressing challenges of clinical trials in acute pain: The Pain Management of Vaso-occlusive Crisis in Children and Young Adults with Sickle Cell Disease Study.
Topics: Acute Disease; Acute Pain; Adolescent; Adult; Amines; Analgesics; Anemia, Sickle Cell; Child; Child, | 2016 |
A randomized, placebo-controlled trial of oxycodone and of gabapentin for acute pain in herpes zoster.
Topics: Acute Disease; Aged; Amines; Analgesics, Opioid; Clinical Trials as Topic; Cyclohexanecarboxylic Aci | 2009 |
Adding gabapentin to a multimodal regimen does not reduce acute pain, opioid consumption or chronic pain after total hip arthroplasty.
Topics: Acute Disease; Aged; Amines; Analgesics; Analgesics, Opioid; Anesthesia, Spinal; Arthroplasty, Repla | 2009 |
Adding gabapentin to a multimodal regimen does not reduce acute pain, opioid consumption or chronic pain after total hip arthroplasty.
Topics: Acute Disease; Aged; Amines; Analgesics; Analgesics, Opioid; Anesthesia, Spinal; Arthroplasty, Repla | 2009 |
Adding gabapentin to a multimodal regimen does not reduce acute pain, opioid consumption or chronic pain after total hip arthroplasty.
Topics: Acute Disease; Aged; Amines; Analgesics; Analgesics, Opioid; Anesthesia, Spinal; Arthroplasty, Repla | 2009 |
Adding gabapentin to a multimodal regimen does not reduce acute pain, opioid consumption or chronic pain after total hip arthroplasty.
Topics: Acute Disease; Aged; Amines; Analgesics; Analgesics, Opioid; Anesthesia, Spinal; Arthroplasty, Repla | 2009 |
Acupuncture in acute herpes zoster pain therapy (ACUZoster) - design and protocol of a randomised controlled trial.
Topics: Acupuncture Therapy; Acute Disease; Adult; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxyli | 2009 |
Acupuncture in acute herpes zoster pain therapy (ACUZoster) - design and protocol of a randomised controlled trial.
Topics: Acupuncture Therapy; Acute Disease; Adult; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxyli | 2009 |
Acupuncture in acute herpes zoster pain therapy (ACUZoster) - design and protocol of a randomised controlled trial.
Topics: Acupuncture Therapy; Acute Disease; Adult; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxyli | 2009 |
Acupuncture in acute herpes zoster pain therapy (ACUZoster) - design and protocol of a randomised controlled trial.
Topics: Acupuncture Therapy; Acute Disease; Adult; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxyli | 2009 |
A comparison of gabapentin and ketamine in acute and chronic pain after hysterectomy.
Topics: Acute Disease; Administration, Oral; Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analg | 2009 |
A comparison of gabapentin and ketamine in acute and chronic pain after hysterectomy.
Topics: Acute Disease; Administration, Oral; Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analg | 2009 |
A comparison of gabapentin and ketamine in acute and chronic pain after hysterectomy.
Topics: Acute Disease; Administration, Oral; Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analg | 2009 |
A comparison of gabapentin and ketamine in acute and chronic pain after hysterectomy.
Topics: Acute Disease; Administration, Oral; Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analg | 2009 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Evaluation of efficacy of the perioperative administration of Venlafaxine or gabapentin on acute and chronic postmastectomy pain.
Topics: Acute Disease; Adult; Amines; Analgesics; Breast Neoplasms; Chronic Disease; Cyclohexanecarboxylic A | 2010 |
Effects of pregabalin on acute herpetic pain and postherpetic neuralgia incidence.
Topics: Acute Disease; Adult; Aged; Analgesics; Double-Blind Method; Female; gamma-Aminobutyric Acid; Herpes | 2010 |
The effects of gabapentin on acute and chronic postoperative pain after coronary artery bypass graft surgery.
Topics: Acute Disease; Aged; Amines; Analgesics; Analgesics, Opioid; Chronic Disease; Chronic Pain; Coronary | 2011 |
Adjunctive treatment with gabapentin in bipolar patients during acute mania.
Topics: Acute Disease; Age Distribution; Amines; Analysis of Variance; Antimanic Agents; Bipolar Disorder; C | 2012 |
Analgesic effects of gabapentin after spinal surgery.
Topics: Acetates; Acute Disease; Adult; Amines; Analgesics; Cyclohexanecarboxylic Acids; Double-Blind Method | 2004 |
A single dose of gabapentin reduces acute pain and allodynia in patients with herpes zoster.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Amines; Analgesics; Anticonvulsants; Cross-Over Studi | 2005 |
Multimodal analgesia with gabapentin and local anesthetics prevents acute and chronic pain after breast surgery for cancer.
Topics: Acute Disease; Adult; Amines; Analgesia; Anesthetics, Local; Breast Neoplasms; Chronic Disease; Cycl | 2005 |
Clinical experience with gabapentin in patients with bipolar or schizoaffective disorder: results of an open-label study.
Topics: Acetates; Acute Disease; Adult; Aged; Amines; Anticonvulsants; Antimanic Agents; Antipsychotic Agent | 1999 |
Gabapentin in the acute treatment of refractory bipolar disorder.
Topics: Acetates; Acute Disease; Adult; Amines; Antimanic Agents; Bipolar Disorder; Cyclohexanecarboxylic Ac | 1999 |
Neurological deterioration in acute lacunar infarctions: the role of excitatory and inhibitory neurotransmitters.
Topics: Acute Disease; Aged; Brain Infarction; Disease Progression; Female; gamma-Aminobutyric Acid; Glutami | 2001 |
The evolving role of topiramate among other mood stabilizers in the management of bipolar disorder.
Topics: Acetates; Acute Disease; Amines; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine; | 2001 |
107 other studies available for gamma-aminobutyric acid and Acute Disease
| Article | Year |
|---|---|
A Noninvasive Urine Metabolome Panel as Potential Biomarkers for Diagnosis of T Cell-Mediated Renal Transplant Rejection.
Topics: Acute Disease; Adenosine Diphosphate; Adult; Biomarkers; Cholesterol Esters; Cross-Sectional Studies | 2020 |
Anxiolytic Effects of 8-O-Acetyl Shanzhiside Methylester on Acute and Chronic Anxiety via Inflammatory Response Inhibition and Excitatory/Inhibitory Transmission Imbalance.
Topics: Acute Disease; Animals; Anti-Anxiety Agents; Anxiety; Chronic Disease; Dose-Response Relationship, D | 2020 |
Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models.
Topics: Acute Disease; Animals; Basic-Leucine Zipper Transcription Factors; Chronic Disease; Disease Models, | 2021 |
Protective roles of hepatic gamma-aminobutyric acid signaling in acute ethanol exposure-induced liver injury.
Topics: Acute Disease; Adult; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Disease Models, An | 2018 |
PACAP-(6-38) or kynurenate microinjections in the RVLM prevent the development of sympathetic long-term facilitation after acute intermittent hypoxia.
Topics: Acute Disease; Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Hypertension | 2018 |
Acute dystonic reaction caused by gabapentin.
Topics: Acute Disease; Adult; Amines; Anti-Anxiety Agents; Cyclohexanecarboxylic Acids; Dystonia; Gabapentin | 2014 |
Pharmacological characterization of standard analgesics on oxaliplatin-induced acute cold hypersensitivity in mice.
Topics: Acute Disease; Amines; Analgesics; Animals; Antineoplastic Agents; Calcium Gluconate; Cryopyrin-Asso | 2014 |
Gabapentin, a synthetic analogue of gamma aminobutyric acid, reverses systemic acute inflammation and oxidative stress in mice.
Topics: Acute Disease; Amines; Animals; Anti-Inflammatory Agents; Cyclohexanecarboxylic Acids; Edema; Gabape | 2014 |
Differences in prefrontal cortex GABA/glutamate ratio after acute restraint stress in rats are associated with specific behavioral and neurobiological patterns.
Topics: Acute Disease; Adenylate Kinase; Animals; Corticosterone; Exploratory Behavior; gamma-Aminobutyric A | 2015 |
Chronic stress shifts the GABA reversal potential in the hippocampus and increases seizure susceptibility.
Topics: Acute Disease; Animals; Bumetanide; Chronic Disease; Corticosterone; Disease Models, Animal; gamma-A | 2015 |
Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus.
Topics: Acute Disease; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Bridged Bicyclo Compounds, Hete | 2014 |
In vivo two-photon imaging of structural dynamics in the spinal dorsal horn in an inflammatory pain model.
Topics: Acute Disease; Amines; Animals; Calcium Channel Blockers; Calcium Channels; Cyclohexanecarboxylic Ac | 2015 |
[Cognitive and emotional impairments in patients with protracted anxiety-phobic disorders].
Topics: Acute Disease; Adolescent; Adult; Chronic Disease; Cognition Disorders; gamma-Aminobutyric Acid; Hum | 2014 |
Acute stress effects on GABA and glutamate levels in the prefrontal cortex: A 7T
Topics: Acute Disease; Adolescent; Adult; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Hydrocorti | 2017 |
Pregabalin as a probable cause of acute liver injury.
Topics: Acute Disease; Analgesics; Chemical and Drug Induced Liver Injury; gamma-Aminobutyric Acid; Herpes Z | 2008 |
Baclofen does not counteract the acute effects of ethanol on flash-evoked potentials in Long-Evans rats.
Topics: Acute Disease; Alcohol-Induced Disorders, Nervous System; Animals; Arousal; Baclofen; Drug Synergism | 2008 |
Pregabalin for acute pain management: a shift in paradigm.
Topics: Acute Disease; Analgesics, Non-Narcotic; Drug Administration Schedule; gamma-Aminobutyric Acid; Huma | 2009 |
[Effect of a simple morphine system injection in some aminoacids in the anterior cingulate cortex during acute pain].
Topics: Acute Disease; Amino Acids; Analgesics, Opioid; Animals; Arginine; Aspartic Acid; Cerebral Cortex; D | 2008 |
Acute limbic encephalitis and glutamic acid decarboxylase antibodies: a reality?
Topics: Acute Disease; Adult; Anti-Inflammatory Agents; Autoantibodies; Biomarkers; Electroencephalography; | 2009 |
Replacement with GABAergic steroid precursors restores the acute ethanol withdrawal profile in adrenalectomy/gonadectomy mice.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Acute Disease; Alcohol-Induced | 2010 |
[Changes of gamma-aminobutyric acid and glycine released in the medial vestibular nucleus following acute hypotension in conscious rats].
Topics: Acute Disease; Animals; Chromatography, High Pressure Liquid; Ear, Inner; gamma-Aminobutyric Acid; G | 2010 |
Changes of some amino acid concentrations in the medial vestibular nucleus of conscious rats following acute hypotension.
Topics: Acute Disease; Animals; Blood Pressure; Chromatography, High Pressure Liquid; gamma-Aminobutyric Aci | 2010 |
Effect of acute psychological stress on prefrontal GABA concentration determined by proton magnetic resonance spectroscopy.
Topics: Acute Disease; Adult; Animals; Anxiety; Anxiety Disorders; Aspartic Acid; Choline; Diagnostic and St | 2010 |
Incidence of postherpetic neuralgia after combination treatment with gabapentin and valacyclovir in patients with acute herpes zoster: open-label study.
Topics: Acute Disease; Acyclovir; Aged; Amines; Analgesics; Antiviral Agents; Cyclohexanecarboxylic Acids; D | 2011 |
Efficacy of pregabalin in acute postoperative pain: a meta-analysis.
Topics: Acute Disease; Analgesics, Non-Narcotic; gamma-Aminobutyric Acid; Humans; Meta-Analysis as Topic; Pa | 2011 |
Low-magnesium medium induces epileptiform activity in mouse olfactory bulb slices.
Topics: Action Potentials; Acute Disease; Animals; Animals, Outbred Strains; Anticonvulsants; Culture Media; | 2011 |
Phenytoin, levetiracetam, and pregabalin in the acute management of refractory status epilepticus in patients with brain tumors.
Topics: Acute Disease; Aged; Anticonvulsants; Brain Neoplasms; Drug Therapy, Combination; Female; gamma-Amin | 2012 |
[About the neuropathic component of back pain].
Topics: Acute Disease; Analgesics; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Chroni | 2012 |
Cannabinoid modulation of midbrain urocortin 1 neurones during acute and chronic stress.
Topics: Acute Disease; Animals; Anxiety; Behavior, Animal; Chronic Disease; Endocannabinoids; gamma-Aminobut | 2012 |
[Case of acute exacerbation of neuropathic cancer pain rapidly relieved by simultaneous oral intake of immediate release oxycodone and pregabalin].
Topics: Acute Disease; Administration, Oral; Adult; Bone Neoplasms; Drug Combinations; gamma-Aminobutyric Ac | 2012 |
Anticonvulsant effects by bilateral and unilateral transplantation of GABA-producing cells into the subthalamic nucleus in an acute seizure model.
Topics: Acute Disease; Animals; Brain Tissue Transplantation; Corpus Striatum; Disease Models, Animal; Femal | 2014 |
Comparison of antiepileptic drugs tiagabine, lamotrigine, and gabapentin in mouse models of acute, prolonged, and chronic nociception.
Topics: Acetates; Acute Disease; Adrenergic alpha-Agonists; Amines; Analgesics, Non-Narcotic; Analgesics, Op | 2002 |
[Changes in adaptation-compensatory processes in the course of acute ischemic stroke (clinico-biochemical comparisons)].
Topics: Acid Phosphatase; Acute Disease; Adaptation, Physiological; Excitatory Amino Acids; Female; gamma-Am | 2003 |
Low posttrauma GABA plasma levels as a predictive factor in the development of acute posttraumatic stress disorder.
Topics: Acute Disease; Adult; Biomarkers; Case-Control Studies; Cohort Studies; Female; gamma-Aminobutyric A | 2004 |
[Gabapentine-induced acute hepatitis].
Topics: Acetates; Acute Disease; Amines; Anticonvulsants; Chemical and Drug Induced Liver Injury; Cyclohexan | 2003 |
The anti-hyperalgesic activity of retigabine is mediated by KCNQ potassium channel activation.
Topics: Acute Disease; Amines; Analgesics, Opioid; Animals; Carbamates; Cyclohexanecarboxylic Acids; Disease | 2004 |
Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats.
Topics: Acute Disease; Amines; Amitriptyline; Animals; Conscious Sedation; Cyclohexanecarboxylic Acids; Cycl | 2004 |
Acute vigabatrin retinotoxicity in albino rats depends on light but not GABA.
Topics: Acute Disease; Animals; Anticonvulsants; Darkness; gamma-Aminobutyric Acid; Light; Male; Nipecotic A | 2004 |
Intrathecal gabapentin enhances the analgesic effects of subtherapeutic dose morphine in a rat experimental pancreatitis model.
Topics: Acetates; Acute Disease; Amines; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Bradykin | 2004 |
GABAergic modulation of ventilatory response to acute and sustained hypoxia in obese Zucker rats.
Topics: Acute Disease; Animals; Bicuculline; Carbon Dioxide; Chronic Disease; GABA Antagonists; gamma-Aminob | 2005 |
Comparison of the antinociceptive profiles of gabapentin and 3-methylgabapentin in rat models of acute and persistent pain: implications for mechanism of action.
Topics: Acetates; Acute Disease; Amines; Analgesics; Animals; Benzylamines; Chronic Disease; Cyclohexanecarb | 2005 |
Brain creatine functions to attenuate acute stress responses through GABAnergic system in chicks.
Topics: Acute Disease; Adaptation, Physiological; Animals; Brain; Brain Chemistry; Chickens; Creatine; Disea | 2005 |
Pregabalin-associated acute psychosis and epileptiform EEG-changes.
Topics: Acute Disease; Adult; Anticonvulsants; Dose-Response Relationship, Drug; Electroencephalography; Fem | 2006 |
Midbrain neurotransmitters in acute hypoxic ventilatory response.
Topics: Acute Disease; Animals; gamma-Aminobutyric Acid; Glutamic Acid; Hypoxia; Mesencephalon; Microdialysi | 2006 |
Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats.
Topics: Acute Disease; Amines; Animals; Brain Ischemia; Cyclohexanecarboxylic Acids; Dose-Response Relations | 2006 |
[An experimental study on acute poisoning by fipronil in mice and its pharmaceutical therapy].
Topics: Acute Disease; Animals; Cerebral Cortex; Female; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; | 2006 |
Does acute pain associated with herpes zoster respond to treatment with gabapentin?
Topics: Acute Disease; Amines; Analgesics; Cross-Over Studies; Cyclohexanecarboxylic Acids; Double-Blind Met | 2006 |
Inhibition of pain behavior by GABA(B) receptors in the thalamic ventrobasal complex: effect on normal rats subjected to the formalin test of nociception.
Topics: Acute Disease; Analgesics; Animals; Baclofen; Behavior, Animal; Chronic Disease; Disease Models, Ani | 2006 |
Acute injury to superficial cortex leads to a decrease in synaptic inhibition and increase in excitation in neocortical layer V pyramidal cells.
Topics: Acute Disease; Animals; Brain Injuries; Disease Models, Animal; Epilepsy; Excitatory Postsynaptic Po | 2007 |
Co-modulation of acute ethanol-induced motor impairment by mouse cerebellar adenosinergic A1 and GABA(A) receptor systems.
Topics: Acute Disease; Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Alcohol | 2006 |
Transverse myelitis caused by varicella zoster: case reports.
Topics: Acute Disease; Amines; Amitriptyline; Analgesics, Non-Narcotic; Chickenpox; Cyclohexanecarboxylic Ac | 2007 |
Life-threatening status epilepticus following gabapentin administration in a patient with benign adult familial myoclonic epilepsy.
Topics: Acute Disease; Amines; Anticonvulsants; Benzodiazepines; Cyclohexanecarboxylic Acids; Drug Resistanc | 2007 |
The antidotal effects of high-dosage gamma-aminobutyric acid on acute tetramine poisoning as compared with sodium dimercaptopropane sulfonate.
Topics: Acute Disease; Animals; Antidotes; Bridged-Ring Compounds; gamma-Aminobutyric Acid; Mice; Random All | 2007 |
Case reports: zoster pain in haematological malignancies: effective pain relief with oxycodone in patients unresponsive to other analgesic measures.
Topics: Acute Disease; Aged; Aged, 80 and over; Amines; Analgesics; Antiviral Agents; Cyclohexanecarboxylic | 2007 |
Role of Stellate ganglion block in post CABG sympathetically mediated chest pain.
Topics: Acute Disease; Amines; Antidepressive Agents, Tricyclic; Chest Pain; Coronary Artery Bypass; Cyclohe | 2007 |
Nociceptin-receptor deficiency prevents postherpetic pain without effects on acute herpetic pain in mice.
Topics: Acute Disease; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gab | 2008 |
Acute pregabalin reversal of citalopram-induced sexual dysfunction in generalized anxiety disorder.
Topics: Acute Disease; Adult; Anticonvulsants; Antidepressive Agents, Second-Generation; Anxiety Disorders; | 2008 |
Increased GABA binding in mouse brain following acute swim stress.
Topics: Acute Disease; Analgesia; Animals; Brain; Chronic Disease; Female; gamma-Aminobutyric Acid; Kinetics | 1981 |
Effects of dopamine agonists, catecholamine depletors, and cholinergic and GABAergic drugs on acute dyskinesias in squirrel monkeys.
Topics: Acute Disease; alpha-Methyltyrosine; Animals; Avoidance Learning; Catecholamines; Dyskinesia, Drug-I | 1984 |
[3 cases of acute encephalopathy associated with calcium hopantenate administration].
Topics: Acute Disease; Child, Preschool; Female; gamma-Aminobutyric Acid; Humans; Infant; Intellectual Disab | 1983 |
[GABA-ergic system components and lipid peroxidation in acute exogenous acrylonitrile poisoning].
Topics: Acrylonitrile; Acute Disease; Animals; Epinephrine; Female; gamma-Aminobutyric Acid; Lipid Peroxides | 1982 |
gamma-Aminobutyric acid concentration in cerebrospinal fluid in schizophrenia.
Topics: Acute Disease; Adult; Chronic Disease; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; R | 1981 |
Alterations in extracellular GABA in the ventral hypothalamus of rats in response to acute glucoprivation.
Topics: Acute Disease; Animals; Deoxyglucose; Extracellular Space; gamma-Aminobutyric Acid; Glucose; Hypotha | 1995 |
Acute pancreatitis associated with dual vigabatrin and lamotrigine therapy.
Topics: Acute Disease; Adult; Amylases; Anticonvulsants; Epilepsy, Complex Partial; gamma-Aminobutyric Acid; | 1994 |
Loss of GABAB binding sites in the cerebral cortex of rats with acute hepatic encephalopathy.
Topics: Acute Disease; Animals; Cerebral Cortex; gamma-Aminobutyric Acid; Hepatic Encephalopathy; In Vitro T | 1993 |
Area-dependent changes in GABAergic function after acute and chronic cold stress.
Topics: Acute Disease; Animals; Cerebral Cortex; Chronic Disease; Cold Temperature; gamma-Aminobutyric Acid; | 1993 |
Release of excitatory and inhibitory amino acids from the locus coeruleus of conscious rats by cardiovascular stimuli and various forms of acute stress.
Topics: Acute Disease; Amino Acids; Animals; Antihypertensive Agents; Arginine; Aspartic Acid; Cardiovascula | 1995 |
Neuroprotection by propofol in acute mechanical injury: role of GABAergic inhibition.
Topics: Acute Disease; Anesthetics, Intravenous; Animals; Brain Injuries; Dendrites; gamma-Aminobutyric Acid | 1996 |
Treatment of acute mania with gabapentin.
Topics: Acetates; Acute Disease; Adult; Amines; Anticonvulsants; Bipolar Disorder; Cyclohexanecarboxylic Aci | 1997 |
The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain.
Topics: Acetates; Acute Disease; Amines; Analgesics; Animals; Anticonvulsants; Chronic Disease; Cyclohexanec | 1997 |
Acute treatment of bipolar depression with gabapentin.
Topics: Acetates; Acute Disease; Adult; Amines; Anticonvulsants; Bipolar Disorder; Cyclohexanecarboxylic Aci | 1997 |
S-(+)-3-isobutylgaba and its stereoisomer reduces the amount of inflammation and hyperalgesia in an acute arthritis model in the rat.
Topics: Acute Disease; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis | 1998 |
Acute encephalopathy associated with vigabatrin monotherapy in patients with mild renal failure.
Topics: Acute Disease; Adult; Aged; Anticonvulsants; Electroencephalography; Encephalitis; Epilepsy, General | 1998 |
Central modulation of formalin-induced acute peripheral inflammation & pain by some putative amino acid neurotransmitters in rats.
Topics: Acute Disease; Amino Acids; Animals; Aspartic Acid; Brain; Formaldehyde; gamma-Aminobutyric Acid; In | 1998 |
[Levels of neurotransmitter amino acids in the cerebrospinal fluid of patients with acute ischemic stroke].
Topics: Acute Disease; Aspartic Acid; Brain Ischemia; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycin | 1999 |
Gabapentin as monotherapy in the treatment of acute mania.
Topics: Acetates; Acute Disease; Adult; Amines; Anticonvulsants; Bipolar Disorder; Cyclohexanecarboxylic Aci | 1999 |
Changes of GABA metabolic enzymes in acute retinal ischemia.
Topics: 4-Aminobutyrate Transaminase; Acute Disease; Animals; gamma-Aminobutyric Acid; Glutamate Decarboxyla | 1999 |
Open maintenance treatment of bipolar disorder spectrum patients who responded to gabapentin augmentation in the acute phase of treatment.
Topics: Acetates; Acute Disease; Adult; Amines; Antimanic Agents; Bipolar Disorder; Cyclohexanecarboxylic Ac | 1999 |
Gabapentin in acute painful diabetic neuropathy.
Topics: Acetates; Acute Disease; Aged; Amines; Analgesics; Cyclohexanecarboxylic Acids; Diabetic Neuropathie | 2000 |
Reversible acute renal allograft dysfunction due to gabapentin.
Topics: Acetates; Acute Disease; Adult; Amines; Analgesics; Cyclohexanecarboxylic Acids; Female; Gabapentin; | 2000 |
Herpes zoster.
Topics: Acetates; Acute Disease; Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobut | 2000 |
Could flumazenil reverse neurological deficits in acute cerebral ischemia?
Topics: Acute Disease; Brain Ischemia; Carotid Artery Thrombosis; Carotid Artery, Internal; Cerebral Angiogr | 1999 |
Acute hypoxic hypoxia transiently reduces GABA(A) binding site number in developing chick optic lobe.
Topics: Acute Disease; Allosteric Regulation; Animals; Binding Sites; Chick Embryo; GABA Modulators; gamma-A | 2000 |
The effect of streptozotocin-induced diabetes on the release of excitotoxic and other amino acids from the ischemic rat cerebral cortex.
Topics: Acute Disease; Amino Acids; Animals; Blood Glucose; Brain Ischemia; Cerebral Cortex; Chronic Disease | 2001 |
Influence of an abrupt increase in blood pressure on the blood-brain barrier permeability during acute hypertension and epileptic seizures.
Topics: Acute Disease; Adrenergic Agonists; Animals; Blood Pressure; Blood-Brain Barrier; Capillary Permeabi | 2001 |
Activation of spinal ORL-1 receptors prevents acute cutaneous neurogenic inflammation: role of nociceptin-induced suppression of primary afferent depolarization.
Topics: Acute Disease; Animals; Evoked Potentials; gamma-Aminobutyric Acid; Hindlimb; In Vitro Techniques; N | 2002 |
Effects of analgesics on delayed postherpetic pain in mice.
Topics: Acetates; Acute Disease; Acyclovir; Amines; Analgesics; Analgesics, Opioid; Animals; Antiviral Agent | 2002 |
Gabapentin for neuropathic pain following spinal cord injury.
Topics: Acetates; Acute Disease; Adolescent; Adult; Aged; Amines; Chronic Disease; Cyclohexanecarboxylic Aci | 2002 |
Amino acid composition of cerebrospinal fluid in actue neuroinfections in children.
Topics: Acute Disease; Adolescent; Adrenocorticotropic Hormone; Amino Acids; Child; Child, Preschool; Chlora | 1975 |
Brain monoamines in metabolic coma and stroke.
Topics: Acute Disease; Aged; Biogenic Amines; Brain Chemistry; Coma; Diabetic Coma; Dopamine; Female; gamma- | 1978 |
Meeting report: Biochemical aspects of schizophrenia. Alabama, April 1975.
Topics: Acute Disease; Blood Platelets; Chronic Disease; Dopamine; Folic Acid; gamma-Aminobutyric Acid; Hall | 1975 |
Carbohydrate and amino acid metabolism in rat cerebral cortex in moderate and extreme hypercapnia.
Topics: Acute Disease; Alanine; Amino Acids; Ammonia; Anesthesia, General; Animals; Asparagine; Aspartic Aci | 1975 |
The gamma-aminobutyric acid (GABA) system in brain during acute and chronic ethanol intoxication.
Topics: 1-Propanol; 4-Aminobutyrate Transaminase; Acute Disease; Alcoholic Intoxication; Aminobutyrates; Ani | 1975 |
Amino acid release from cerebral cortex in experimental acute liver failure, studied by in vivo cerebral cortex microdialysis.
Topics: Acute Disease; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Dialysis; gamma-Aminobutyric Ac | 1992 |
Acute encephalopathy with hepatic steatosis induced by pantothenic acid antagonist, calcium hopantenate, in dogs.
Topics: Acute Disease; Animals; Brain Diseases; Dogs; Fatty Liver; Female; gamma-Aminobutyric Acid; Liver; M | 1991 |
A case of the Rett syndrome with acute encephalopathy induced during calcium hopantenate treatment.
Topics: Acute Disease; Blood Glucose; Brain Diseases; Carboxylic Acids; Child, Preschool; Female; gamma-Amin | 1991 |
Plasma gamma aminobutyric acid concentrations provide evidence of different mechanisms in the pathogenesis of hepatic encephalopathy in acute and chronic liver disease.
Topics: Acute Disease; Adult; Chronic Disease; Delta Rhythm; Female; gamma-Aminobutyric Acid; Hepatic Enceph | 1989 |
Effects of chronic intracerebroventricular GABAergic treatment on basal and chronic or acute stress-induced adrenocortical activities in the thalamic pigeon.
Topics: Acute Disease; Adrenal Cortex; Animals; Chronic Disease; Columbidae; Corticosterone; Decerebrate Sta | 1986 |
[Prevention of arrhythmias and cardiac fibrillation in acute ischemia and reperfusion by using a factor causing GABA accumulation in the brain].
Topics: Acute Disease; Animals; Arrhythmias, Cardiac; Brain; Coronary Disease; Drug Evaluation, Preclinical; | 1987 |
[Changes in the psychoemotional sphere and their correction in trigeminal neuralgia].
Topics: Acute Disease; Adult; Affective Symptoms; Drug Evaluation; Drug Therapy, Combination; gamma-Aminobut | 1987 |
[GABA synthesis in the central nervous system of rats with extrapyramidal syndrome after acute cobalt acetate poisoning in cerebral ischemia].
Topics: Acetates; Acetic Acid; Acute Disease; Animals; Basal Ganglia Diseases; Brain; gamma-Aminobutyric Aci | 1987 |
Acute encephalopathy with hyperammonemia and dicarboxylic aciduria during calcium hopantenate therapy: a patient report.
Topics: Acute Disease; Ammonia; Brain Diseases; Child, Preschool; Female; gamma-Aminobutyric Acid; Humans; P | 1986 |
[A clinico-biochemical study of acute encephalopathy in patients treated with Ca-hopantenate].
Topics: Acute Disease; Adolescent; Adult; Age Factors; Blood Chemical Analysis; Brain Diseases; Child; Child | 1985 |
[Nootropic drugs in the acute period of cerebral stroke].
Topics: Acute Disease; Cerebrovascular Disorders; Drug Therapy, Combination; gamma-Aminobutyric Acid; Humans | 1985 |
Acute hepatic failure in children.
Topics: Acute Disease; Blood-Brain Barrier; Child; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans; | 1985 |
[Gamma-aminobutyric acid (GABA) levels and glutamate decarboxylase (GAD) activity of the brain of rats with extrapyramidal syndrome after acute manganese chloride poisoning].
Topics: Acute Disease; Brain Chemistry; Chlorides; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; | 1985 |
[Blood serotonin during gammalon treatment of patients with acute cerebrovascular disorders].
Topics: Acute Disease; Adult; Aged; Aminobutyrates; Cerebrovascular Disorders; Female; gamma-Aminobutyric Ac | 1974 |