gamma-aminobutyric acid has been researched along with Abnormal Deep Tendon Reflex in 14 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 44-year-old female with gabapentin-responsive supraorbital neuralgia is presented." | 3.73 | Abnormal blink reflex studies in a patient with supraorbital neuralgia. ( Cohen, AS; Gantenbein, AR; Goadsby, PJ, 2006) |
| "We have generated a FTLD-U mouse model (CaMKII-TDP-43 Tg) in which TDP-43 is transgenically overexpressed in the forebrain resulting in phenotypic characteristics mimicking those of FTLD-U." | 1.36 | Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U. ( Chien, WL; Cho, KH; Fang, YH; Fu, WM; Lin, CP; Shen, CK; Tsai, KJ; Wang, WT; Wu, TW; Yang, CH, 2010) |
| "Both spastic behavior and electromyography (EMG) activity were significantly decreased at 1 and 3 h post-GBP injection when compared with the activity level following administration of saline." | 1.34 | Gabapentin suppresses spasticity in the spinal cord-injured rat. ( Dwyer, MK; Kitzman, PH; Uhl, TL, 2007) |
| "A patient with thymoma-associated neuromyotonia and voltage-gated potassium channel (Kv1." | 1.33 | Sequential antibodies to potassium channels and glutamic acid decarboxylase in neuromyotonia. ( Andreetta, F; Antozzi, C; Bernasconi, P; Chang, T; Ciano, C; Cornelio, F; Frassoni, C; Mantegazza, R; Regondi, MC; Spreafico, R; Vincent, A, 2005) |
| "Startle disease or hyperreflexia is an autosomal dominant neurological disorder, with a neonatal onset, characterized by muscular hypertonia and myoclonic jerks, exaggerated by the slightest stimulus." | 1.29 | Possible involvement of a gamma-hydroxybutyric acid receptor in startle disease. ( Berthier, M; Bonneau, D; Chevrel, J; Desbordes, JM; Jaeken, J; Laborit, H; Oriot, D, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (28.57) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Mu, JD | 1 |
| Ma, LX | 1 |
| Zhang, Z | 1 |
| Yu, WY | 1 |
| Sun, TY | 1 |
| Qian, X | 1 |
| Tian, Y | 1 |
| Wang, JX | 1 |
| Sullivan, RW | 1 |
| Ryzewski, M | 1 |
| Holland, MG | 1 |
| Marraffa, JM | 1 |
| Boulenguez, P | 1 |
| Liabeuf, S | 1 |
| Bos, R | 1 |
| Bras, H | 1 |
| Jean-Xavier, C | 1 |
| Brocard, C | 1 |
| Stil, A | 1 |
| Darbon, P | 1 |
| Cattaert, D | 1 |
| Delpire, E | 1 |
| Marsala, M | 1 |
| Vinay, L | 1 |
| Edgerton, VR | 1 |
| Roy, RR | 1 |
| Tsai, KJ | 1 |
| Yang, CH | 1 |
| Fang, YH | 1 |
| Cho, KH | 1 |
| Chien, WL | 1 |
| Wang, WT | 1 |
| Wu, TW | 1 |
| Lin, CP | 1 |
| Fu, WM | 1 |
| Shen, CK | 1 |
| Antozzi, C | 1 |
| Frassoni, C | 1 |
| Vincent, A | 1 |
| Regondi, MC | 1 |
| Andreetta, F | 1 |
| Bernasconi, P | 1 |
| Ciano, C | 1 |
| Chang, T | 1 |
| Cornelio, F | 1 |
| Spreafico, R | 1 |
| Mantegazza, R | 1 |
| Cohen, AS | 1 |
| Gantenbein, AR | 1 |
| Goadsby, PJ | 1 |
| Vignes, JR | 1 |
| Deloire, MS | 1 |
| Petry, KG | 1 |
| Nagy, F | 1 |
| Kitzman, PH | 1 |
| Uhl, TL | 1 |
| Dwyer, MK | 1 |
| Archer, D | 1 |
| Roth, S | 1 |
| Berthier, M | 2 |
| Oriot, D | 2 |
| Bonneau, D | 2 |
| Jaeken, J | 2 |
| Desbordes, JM | 1 |
| Chevrel, J | 1 |
| Laborit, H | 1 |
| Oshima, T | 1 |
| Sakamoto, M | 1 |
| Tatsuta, H | 1 |
| Arita, H | 1 |
| Averbuch-Heller, L | 1 |
| Stahl, JS | 1 |
| Hlavin, ML | 1 |
| Leigh, RJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
14 other studies available for gamma-aminobutyric acid and Abnormal Deep Tendon Reflex
| Article | Year |
|---|---|
Acupuncture alleviates spinal hyperreflexia and motor dysfunction in post-ischemic stroke rats with spastic hypertonia via KCC2-mediated spinal GABA
Topics: Acupuncture Therapy; Animals; gamma-Aminobutyric Acid; Humans; Ischemic Stroke; Muscle Hypertonia; M | 2022 |
Compounded ointment results in severe toxicity in a pediatric patient.
Topics: Administration, Cutaneous; Amines; Analgesics; Body Surface Area; Bradycardia; Clonidine; Combined M | 2013 |
Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury.
Topics: Animals; Blotting, Western; Brain-Derived Neurotrophic Factor; Carboxylic Acids; Chloride Channels; | 2010 |
Spasticity: a switch from inhibition to excitation.
Topics: Animals; Chloride Channels; Down-Regulation; gamma-Aminobutyric Acid; K Cl- Cotransporters; Membrane | 2010 |
Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U.
Topics: Animals; Apoptosis; Atrophy; Brain; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Caspase 3; C | 2010 |
Sequential antibodies to potassium channels and glutamic acid decarboxylase in neuromyotonia.
Topics: Adult; Animals; Autoantibodies; Autoimmune Diseases of the Nervous System; Blinking; Brain Stem; Cyc | 2005 |
Abnormal blink reflex studies in a patient with supraorbital neuralgia.
Topics: Adult; Amines; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Blinking; Cyclohexanecarboxylic | 2006 |
Characterization and restoration of altered inhibitory and excitatory control of micturition reflex in experimental autoimmune encephalomyelitis in rats.
Topics: Animals; Baclofen; Bicuculline; Cauda Equina; Efferent Pathways; Electric Stimulation; Encephalomyel | 2007 |
Gabapentin suppresses spasticity in the spinal cord-injured rat.
Topics: Amines; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Cross-Over Studies; Cycloh | 2007 |
[Anesthetics are exciting! Implications of pharmacologically-induced nociceptive hyperreflexia].
Topics: Anesthetics; gamma-Aminobutyric Acid; Humans; Nociceptors; Reflex, Abnormal | 2008 |
Does a mutation of the glycine receptor modify GABA metabolism in startle disease?
Topics: gamma-Aminobutyric Acid; Humans; Infant; Muscle Rigidity; Point Mutation; Receptors, Glycine; Reflex | 1995 |
Possible involvement of a gamma-hydroxybutyric acid receptor in startle disease.
Topics: Anesthetics; Anticonvulsants; GABA Agonists; gamma-Aminobutyric Acid; Humans; Infant, Newborn; Male; | 1994 |
GABAergic inhibition of hiccup-like reflex induced by electrical stimulation in medulla of cats.
Topics: Animals; Baclofen; Cats; Cholera Toxin; Electric Stimulation; GABA Agonists; gamma-Aminobutyric Acid | 1998 |
Square-wave jerks induced by pallidotomy in parkinsonian patients.
Topics: Adult; Aged; Female; Fixation, Ocular; gamma-Aminobutyric Acid; Globus Pallidus; Humans; Male; Neura | 1999 |