gamma-aminobutyric acid has been researched along with Abdominal Pain in 16 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Abdominal Pain: Sensation of discomfort, distress, or agony in the abdominal region.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pregabalin, a ligand of alpha(2)delta subunits of voltage-gated calcium channels, reduces visceral hypersensitivity associated with irritable bowel syndrome." | 3.76 | Pregabalin inhibits accelerated defecation and decreased colonic nociceptive threshold in sensitized rats. ( Gale, JD; Kurebayashi, Y; Ohashi-Doi, K, 2010) |
| "Pregabalin, which binds to the alpha2-delta subunit of voltage-gated calcium channels, increased the threshold for pain during colorectal distension (CRD) in irritable bowel syndrome (IBS) patients." | 3.74 | Effects of pregabalin on visceral pain responses and colonic compliance in rats. ( Brusberg, M; Larsson, H; Lindström, E; Martínez, V; Ravnefjord, A, 2008) |
| "Recurrent abdominal pain is a common and costly health-care problem attributed, in part, to visceral hypersensitivity." | 1.46 | GABA-producing Bifidobacterium dentium modulates visceral sensitivity in the intestine. ( Dann, SM; Engler, DA; Fu, Y; Hollister, EB; Johnson, C; Lugo, M; Luk, B; Major, A; Matsunami, RK; Mori-Akiyama, Y; Oezguen, N; Pokusaeva, K; Savidge, T; Shi, XZ; Uribe, G; Versalovic, J, 2017) |
| "The patient was initially treated for her abdominal pain and vomiting." | 1.35 | Drug use in porphyria: a therapeutic dilemma. ( Jimmy, B; Jose, J; Saravu, K; Shastry, BA, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (25.00) | 29.6817 |
| 2010's | 12 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cooper, TE | 1 |
| Heathcote, LC | 1 |
| Clinch, J | 1 |
| Gold, JI | 1 |
| Howard, R | 1 |
| Lord, SM | 1 |
| Schechter, N | 1 |
| Wood, C | 1 |
| Wiffen, PJ | 1 |
| Lv, K | 1 |
| Song, W | 1 |
| Tang, R | 1 |
| Pan, Z | 1 |
| Zhang, Y | 1 |
| Xu, Y | 1 |
| Lv, B | 1 |
| Fan, Y | 1 |
| Xu, M | 1 |
| Bednarska, O | 1 |
| Icenhour, A | 1 |
| Tapper, S | 1 |
| Witt, ST | 1 |
| Tisell, A | 1 |
| Lundberg, P | 1 |
| Elsenbruch, S | 1 |
| Engström, M | 1 |
| Walter, S | 1 |
| Guo, R | 1 |
| Jacobs, RE | 1 |
| Garcia-Alonso, FJ | 1 |
| Bonillo Cambrodón, D | 1 |
| Pokusaeva, K | 1 |
| Johnson, C | 1 |
| Luk, B | 1 |
| Uribe, G | 1 |
| Fu, Y | 1 |
| Oezguen, N | 1 |
| Matsunami, RK | 1 |
| Lugo, M | 1 |
| Major, A | 1 |
| Mori-Akiyama, Y | 1 |
| Hollister, EB | 1 |
| Dann, SM | 1 |
| Shi, XZ | 1 |
| Engler, DA | 1 |
| Savidge, T | 1 |
| Versalovic, J | 1 |
| Erden, V | 1 |
| Abitağaoğlu, S | 1 |
| Güler, C | 1 |
| Doğan, Z | 1 |
| Kırgezen, Ş | 1 |
| Abut, Y | 1 |
| Ravnefjord, A | 1 |
| Brusberg, M | 1 |
| Larsson, H | 1 |
| Lindström, E | 1 |
| Martínez, V | 1 |
| Jose, J | 1 |
| Saravu, K | 1 |
| Shastry, BA | 1 |
| Jimmy, B | 1 |
| Ducrotté, P | 1 |
| Ohashi-Doi, K | 1 |
| Gale, JD | 1 |
| Kurebayashi, Y | 1 |
| Hey, M | 1 |
| Wilson, I | 1 |
| Johnson, MI | 1 |
| Olesen, SS | 1 |
| Bouwense, SA | 1 |
| Wilder-Smith, OH | 1 |
| van Goor, H | 1 |
| Drewes, AM | 1 |
| Silverman, A | 1 |
| Samuels, Q | 1 |
| Gikas, H | 1 |
| Nawras, A | 1 |
| Ibitoye, RT | 1 |
| Rajbhandari, SM | 1 |
| Celebi, N | 1 |
| Sahin, A | 1 |
| Canbay, O | 1 |
| Uzümcügil, F | 1 |
| Aypar, U | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Role of the Gut Microbiome as Determinant of Depression in Multiple Sclerosis Subjects[NCT05808101] | 120 participants (Anticipated) | Observational | 2022-01-27 | Recruiting | |||
| Comparison of Plasma Orexin-A Levels and Awakening Time From Anesthesia in Patients With and Without Insomnia Who Had Laparoscopic Cholecystectomy Under General Anesthesia[NCT05664295] | 60 participants (Actual) | Observational [Patient Registry] | 2022-12-30 | Completed | |||
| Impact of Personalized Education on Pain Response in Patients With Chronic Pancreatitis (PEPCP)[NCT04654377] | 140 participants (Anticipated) | Interventional | 2021-06-29 | Recruiting | |||
| Evaluation of Efficacy of Combination of Pregabalin and Antioxidant in Reducing Pain in Chronic Pancreatitis: a RCT[NCT01528540] | 87 participants (Actual) | Interventional | 2012-04-30 | Completed | |||
| Pregabalin for the Treatment of Abdominal Pain From Adhesions: Placebo Controlled Trial[NCT00310765] | Phase 4 | 18 participants (Actual) | Interventional | 2006-03-31 | Terminated (stopped due to Study was terminated by the sponsor due to low accrual.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Patients were randomized to pregabalin or placebo 75 mg twice a day. Patients were allowed to double the dose on day 3 if adequate pain relief was not obtained. Abdominal pain reduction was measured on a Likert scale. A Likert scale assumes the intensity of pain is linear on a continuum from no pain at level 0 to severe pain at level 10. Patients were required to complete a daily dairy recording pain using the Likert 11-point numeric scale. The primary end point was a positive change in the daily pain diary of 2 points from each patient's baseline at weeks 8 after the completion of the blinded study and at week 12 during the open label portion of the study. After 7 weeks all patients are randomized to study drug pregabalin 150 to 300 mg daily for 4 additional weeks after a one week wash out with no medication. (NCT00310765)
Timeframe: Baseline and week 2 through week 12
| Intervention | units on a scale (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| baseline pain score | week 2 | week 3 | week 4 | week 5 | week 6 | week 7 | week 8 open label with no study medication | week 9 open label | week 10 open label | week 11 open label | week 12 open label | |
| Patients Treated With Placebo | 5.8 | 5.22 | 4.64 | 4.84 | 4.32 | 3.88 | 3.92 | 4.13 | 2.21 | 2.27 | 2.23 | 1.13 |
| Patients Treated With Pregabalin | 6.15 | 2.87 | 1.88 | 3.31 | 2.72 | 2.49 | 2.53 | 2.46 | 2.06 | 1.84 | 1.46 | 1.68 |
Absolute Improvement in Sleep by assessing Mean Daily sleep interference scores as measured weekly starting at baseline and reported weekly through week 12 excluding the first week. This score is an 11 point scale the documents the pain interference in sleep in the preceding 24 hours. 0 is no interference and 10 is pain completely disrupted sleep in the previous 24 hours. During the study patients recorded a daily sleep interference score based on 11 point scale (0-10) with the higher number being the most sleep interference (NCT00310765)
Timeframe: Baseline and week 2 through week 12
| Intervention | units on a scale (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| baseline | week 2 | week 3 | week 4 | week 5 | week 6 | week 7 | week 8 open label no study medication | week 9 open label | week 10 open label | week 11 open label | week 12 open label | |
| Placebo | 4.66 | 3.4 | 3.26 | 3.54 | 3.06 | 2.74 | 3.18 | 3.30 | 1.70 | 1.25 | 1.18 | 0.56 |
| Pregabalin | 3.94 | 2.20 | 1.60 | 1.68 | 1.68 | 1.55 | 1.6 | 1.82 | 1.31 | 1.37 | 1.39 | 1.01 |
1 review available for gamma-aminobutyric acid and Abdominal Pain
| Article | Year |
|---|---|
Antidepressants for chronic non-cancer pain in children and adolescents.
Topics: Abdominal Pain; Adolescent; Amines; Amitriptyline; Analgesics; Antidepressive Agents; Child; Chronic | 2017 |
2 trials available for gamma-aminobutyric acid and Abdominal Pain
| Article | Year |
|---|---|
Pregabalin reduces pain in patients with chronic pancreatitis in a randomized, controlled trial.
Topics: Abdominal Pain; Adult; Aged; Analgesics; Double-Blind Method; Female; gamma-Aminobutyric Acid; Healt | 2011 |
Pregabalin reduces pain in patients with chronic pancreatitis in a randomized, controlled trial.
Topics: Abdominal Pain; Adult; Aged; Analgesics; Double-Blind Method; Female; gamma-Aminobutyric Acid; Healt | 2011 |
Pregabalin reduces pain in patients with chronic pancreatitis in a randomized, controlled trial.
Topics: Abdominal Pain; Adult; Aged; Analgesics; Double-Blind Method; Female; gamma-Aminobutyric Acid; Healt | 2011 |
Pregabalin reduces pain in patients with chronic pancreatitis in a randomized, controlled trial.
Topics: Abdominal Pain; Adult; Aged; Analgesics; Double-Blind Method; Female; gamma-Aminobutyric Acid; Healt | 2011 |
Pregabalin for the treatment of abdominal adhesion pain: a randomized, double-blind, placebo-controlled trial.
Topics: Abdomen; Abdominal Pain; Adult; Analgesics; Chronic Pain; Double-Blind Method; Female; gamma-Aminobu | 2012 |
13 other studies available for gamma-aminobutyric acid and Abdominal Pain
| Article | Year |
|---|---|
Neurotransmitter alterations in the anterior cingulate cortex in Crohn's disease patients with abdominal pain: A preliminary MR spectroscopy study.
Topics: Abdominal Pain; Adult; Crohn Disease; Female; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli; | 2018 |
Reduced excitatory neurotransmitter levels in anterior insulae are associated with abdominal pain in irritable bowel syndrome.
Topics: Abdominal Pain; Adolescent; Adult; Cerebral Cortex; Excitatory Amino Acid Agonists; Excitatory Amino | 2019 |
Management of Peripheral Entrapment Neuropathy Following Abdominoplasty: A Case Report.
Topics: Abdominal Pain; Abdominoplasty; Adult; Amines; Analgesics; Cyclohexanecarboxylic Acids; Female; Foll | 2016 |
Thinking Outside the Box.
Topics: Abdominal Pain; Aged; Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyri | 2016 |
GABA-producing Bifidobacterium dentium modulates visceral sensitivity in the intestine.
Topics: Abdominal Pain; Animals; Base Sequence; Bifidobacterium; Cell Line; Feces; gamma-Aminobutyric Acid; | 2017 |
Insomnia may increase anesthetic requirement.
Topics: Abdominal Pain; Adult; Anesthetics, Inhalation; Carbon Dioxide; Cholecystectomy, Laparoscopic; Consc | 2016 |
Effects of pregabalin on visceral pain responses and colonic compliance in rats.
Topics: Abdominal Pain; Administration, Oral; Analgesics; Animals; Blood Pressure; Calcium Channels; Colon; | 2008 |
Drug use in porphyria: a therapeutic dilemma.
Topics: Abdominal Pain; Adult; Amines; Anticonvulsants; Antiemetics; Antihypertensive Agents; Chest Pain; Cy | 2008 |
[Irritable bowel syndrome: dietary and pharmacological therapeutic options].
Topics: Abdominal Pain; Analgesics; Anesthetics, Local; Anti-Bacterial Agents; Antidepressive Agents; Centra | 2009 |
Pregabalin inhibits accelerated defecation and decreased colonic nociceptive threshold in sensitized rats.
Topics: Abdominal Pain; Analgesics; Animals; Defecation; Dose-Response Relationship, Drug; gamma-Aminobutyri | 2010 |
Stellate ganglion blockade (SGB) for refractory index finger pain - a case report.
Topics: Abdominal Pain; Accidental Falls; Acetaminophen; Adult; Amines; Autonomic Nerve Block; Chronic Disea | 2011 |
Neuropathic truncal pain--a case series.
Topics: Abdominal Pain; Adolescent; Adult; Amines; Analgesics; Anesthetics, Local; Antidepressive Agents; Ch | 2012 |
Abdominal pain related to mitochondrial neurogastrointestinal encephalomyopathy syndrome may benefit from splanchnic nerve blockade.
Topics: Abdominal Pain; Adolescent; Amines; Analgesics; Anesthetics, Local; Cyclohexanecarboxylic Acids; Ele | 2006 |