gamma-aminobutyric acid has been researched along with ADDH in 37 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neurodevelopmental disorders (NDDs) including autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD) are thought to arise in part from the disruption in the excitatory/inhibitory balance of gamma-aminobutyric acid (GABA) and glutamate in the brain." | 8.31 | Cerebellar gamma-aminobutyric acid: Investigation of group effects in neurodevelopmental disorders. ( Anagnostou, E; Arnold, PD; Crosbie, J; Hammill, C; Lerch, JP; Near, J; Pang, EW; Schachar, R; Taylor, MJ, 2023) |
| "Autistic Disorder is an early-onset developmental disorder with severe lifelong impact on social functioning, communication, and behavior." | 5.31 | Elevated plasma gamma-aminobutyric acid (GABA) levels in autistic youngsters: stimulus for a GABA hypothesis of autism. ( Abraham, A; Applegate, H; Bencsath, A; Bland, L; Dhossche, D; Maertens, P; Martinez, J, 2002) |
| "Gabapentin is an anticonvulsant drug released in the United States in 1993 for use as adjunctive therapy in refractory partial epilepsy." | 5.31 | Gabapentin and methylphenidate treatment of a preadolescent with attention deficit hyperactivity disorder and bipolar disorder. ( Bailey, K; Hamrin, V, 2001) |
| "Neurodevelopmental disorders (NDDs) including autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD) are thought to arise in part from the disruption in the excitatory/inhibitory balance of gamma-aminobutyric acid (GABA) and glutamate in the brain." | 4.31 | Cerebellar gamma-aminobutyric acid: Investigation of group effects in neurodevelopmental disorders. ( Anagnostou, E; Arnold, PD; Crosbie, J; Hammill, C; Lerch, JP; Near, J; Pang, EW; Schachar, R; Taylor, MJ, 2023) |
| "Insomnia is a common phenomenon particularly in patients with epilepsy." | 2.77 | Pregabalin increases slow-wave sleep and may improve attention in patients with partial epilepsy and insomnia. ( Bazil, CW; Cole, J; Dave, J; Drake, E; Stalvey, J, 2012) |
| " Systemically, chronic administration of therapeutically relevant doses of guanfacine for 14 days increased the basal release of norepinephrine in the OFC, VTA, RTN, and dopamine release in the OFC via the downregulation of the α2A adrenoceptor in the LC, OFC and VTA." | 1.62 | Chronic Administrations of Guanfacine on Mesocortical Catecholaminergic and Thalamocortical Glutamatergic Transmissions. ( Fukuyama, K; Nakano, T; Okada, M; Shiroyama, T, 2021) |
| "All patients had substance use disorders, the large majority (72 %) to more than one substance." | 1.43 | Abuse of Gabapentin is Associated with Opioid Addiction. ( Bastiaens, L; Galus, J; Mazur, C, 2016) |
| "Fifty-eight percent had an opioid use disorder, again mostly in combination with other drugs and/or alcohol." | 1.43 | Abuse of Gabapentin is Associated with Opioid Addiction. ( Bastiaens, L; Galus, J; Mazur, C, 2016) |
| "Autistic Disorder is an early-onset developmental disorder with severe lifelong impact on social functioning, communication, and behavior." | 1.31 | Elevated plasma gamma-aminobutyric acid (GABA) levels in autistic youngsters: stimulus for a GABA hypothesis of autism. ( Abraham, A; Applegate, H; Bencsath, A; Bland, L; Dhossche, D; Maertens, P; Martinez, J, 2002) |
| "Its use in patients with attention deficit disorder with hyperactivity has shown significant improvement in neuropsychological studies." | 1.31 | [Models of drug treatment in the attention deficit disorder with hyperactivity]. ( Etchepareborda, MC, 2002) |
| "Gabapentin is an anticonvulsant drug released in the United States in 1993 for use as adjunctive therapy in refractory partial epilepsy." | 1.31 | Gabapentin and methylphenidate treatment of a preadolescent with attention deficit hyperactivity disorder and bipolar disorder. ( Bailey, K; Hamrin, V, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.41) | 18.7374 |
| 1990's | 2 (5.41) | 18.2507 |
| 2000's | 8 (21.62) | 29.6817 |
| 2010's | 16 (43.24) | 24.3611 |
| 2020's | 9 (24.32) | 2.80 |
| Authors | Studies |
|---|---|
| Kovalev, GI | 1 |
| Sukhorukova, NA | 1 |
| Vasileva, EV | 1 |
| Kondrakhin, EA | 1 |
| Salimov, RM | 1 |
| Miniksar, DY | 1 |
| Cansız, MA | 1 |
| Kılıç, M | 1 |
| Göçmen, AY | 1 |
| Lee, IO | 1 |
| Skuse, DH | 1 |
| Constable, PA | 1 |
| Marmolejo-Ramos, F | 1 |
| Olsen, LR | 1 |
| Thompson, DA | 1 |
| Mamiya, PC | 1 |
| Richards, TL | 1 |
| Edden, RAE | 3 |
| Lee, AKC | 1 |
| Stein, MA | 1 |
| Kuhl, PK | 1 |
| Pang, EW | 1 |
| Hammill, C | 1 |
| Taylor, MJ | 1 |
| Near, J | 1 |
| Schachar, R | 1 |
| Crosbie, J | 1 |
| Arnold, PD | 1 |
| Anagnostou, E | 1 |
| Lerch, JP | 1 |
| Puts, NA | 1 |
| Ryan, M | 1 |
| Oeltzschner, G | 1 |
| Horska, A | 1 |
| Mahone, EM | 1 |
| Hai, T | 1 |
| Swansburg, R | 1 |
| Kahl, CK | 1 |
| Frank, H | 1 |
| Lemay, JF | 1 |
| MacMaster, FP | 3 |
| Harris, AD | 1 |
| Gilbert, DL | 2 |
| Horn, PS | 1 |
| Crocetti, D | 2 |
| Cecil, KM | 1 |
| Huddleston, DA | 1 |
| Mostofsky, SH | 2 |
| Puts, NAJ | 1 |
| Fukuyama, K | 1 |
| Nakano, T | 1 |
| Shiroyama, T | 1 |
| Okada, M | 1 |
| Nagai, J | 1 |
| Rajbhandari, AK | 1 |
| Gangwani, MR | 1 |
| Hachisuka, A | 1 |
| Coppola, G | 1 |
| Masmanidis, SC | 1 |
| Fanselow, MS | 1 |
| Khakh, BS | 1 |
| Dunn, GA | 1 |
| Nigg, JT | 1 |
| Sullivan, EL | 1 |
| Sterley, TL | 2 |
| Howells, FM | 2 |
| Russell, VA | 2 |
| Zavadenko, NN | 2 |
| Suvorinova, NIu | 2 |
| Ende, G | 1 |
| Cackowski, S | 1 |
| Van Eijk, J | 1 |
| Sack, M | 1 |
| Demirakca, T | 1 |
| Kleindienst, N | 1 |
| Bohus, M | 1 |
| Sobanski, E | 1 |
| Krause-Utz, A | 1 |
| Schmahl, C | 1 |
| Chen, L | 1 |
| Yang, X | 1 |
| Zhou, X | 1 |
| Wang, C | 1 |
| Gong, X | 1 |
| Chen, B | 1 |
| Chen, Y | 1 |
| Bollmann, S | 1 |
| Ghisleni, C | 1 |
| Poil, SS | 1 |
| Martin, E | 1 |
| Ball, J | 1 |
| Eich-Höchli, D | 1 |
| Edden, RA | 2 |
| Klaver, P | 1 |
| Michels, L | 1 |
| Brandeis, D | 1 |
| O'Gorman, RL | 1 |
| Tzanoulinou, S | 1 |
| García-Mompó, C | 1 |
| Riccio, O | 1 |
| Grosse, J | 1 |
| Zanoletti, O | 1 |
| Dedousis, P | 1 |
| Nacher, J | 1 |
| Sandi, C | 1 |
| Rivero, O | 1 |
| Selten, MM | 1 |
| Sich, S | 1 |
| Popp, S | 1 |
| Bacmeister, L | 1 |
| Amendola, E | 1 |
| Negwer, M | 1 |
| Schubert, D | 1 |
| Proft, F | 1 |
| Kiser, D | 1 |
| Schmitt, AG | 1 |
| Gross, C | 1 |
| Kolk, SM | 1 |
| Strekalova, T | 1 |
| van den Hove, D | 1 |
| Resink, TJ | 1 |
| Nadif Kasri, N | 1 |
| Lesch, KP | 1 |
| Bastiaens, L | 1 |
| Galus, J | 1 |
| Mazur, C | 1 |
| Naaijen, J | 1 |
| Bralten, J | 1 |
| Poelmans, G | 1 |
| Glennon, JC | 1 |
| Franke, B | 1 |
| Buitelaar, JK | 1 |
| Ferreira, PE | 1 |
| Palmini, A | 1 |
| Bau, CH | 1 |
| Grevet, EH | 1 |
| Hoefel, JR | 1 |
| Rohde, LA | 1 |
| Anés, M | 1 |
| Ferreira, EE | 1 |
| Belmonte-de-Abreu, P | 1 |
| Waddell, J | 1 |
| McCarthy, MM | 1 |
| Bazil, CW | 1 |
| Dave, J | 1 |
| Cole, J | 1 |
| Stalvey, J | 1 |
| Drake, E | 1 |
| Mc Fie, S | 1 |
| Zhu, H | 1 |
| Dhossche, D | 1 |
| Applegate, H | 1 |
| Abraham, A | 1 |
| Maertens, P | 1 |
| Bland, L | 1 |
| Bencsath, A | 1 |
| Martinez, J | 1 |
| Etchepareborda, MC | 1 |
| Carrey, N | 1 |
| Sparkes, S | 1 |
| Kusumakar, V | 1 |
| Sparkes, SJ | 1 |
| Carrey, NC | 1 |
| Saxena, K | 1 |
| Howe, M | 1 |
| Simeonova, D | 1 |
| Steiner, H | 1 |
| Chang, K | 1 |
| Plessen, KJ | 1 |
| Royal, JM | 1 |
| Peterson, BS | 1 |
| Wray, SR | 1 |
| Melville, GN | 1 |
| Grell, GA | 1 |
| Edge, PC | 1 |
| Ryback, R | 1 |
| Ryback, L | 1 |
| Lee, DO | 1 |
| Steingard, RJ | 1 |
| Cesena, M | 1 |
| Helmers, SL | 1 |
| Riviello, JJ | 1 |
| Mikati, MA | 1 |
| Hamrin, V | 1 |
| Bailey, K | 1 |
| Lupandin, VM | 1 |
| Lando, LI | 1 |
| Gromova, EA | 1 |
| Kamenskaia, VM | 1 |
| Zykov, MB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Open Label Study for the Use of Transcranial Ultrasound Treatment of Attention Deficit Hyperactive Disorder[NCT04497363] | 100 participants (Anticipated) | Interventional | 2020-07-01 | Enrolling by invitation | |||
| Measuring Glutamate and GABA Brain Levels in Adults With Attention Deficit Hyperactivity Disorder (ADHD) Using Magnetic Resonance Spectroscopy (MRS)[NCT04823364] | 60 participants (Anticipated) | Interventional | 2022-10-01 | Not yet recruiting | |||
| Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776] | Phase 2 | 54 participants (Actual) | Interventional | 2017-08-07 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 3.90 |
| Gabapentin | 3.93 |
| Placebo Oral Tablet | 3.73 |
Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 21.59 |
| Gabapentin | 21.69 |
| Placebo Oral Tablet | 22.25 |
3 reviews available for gamma-aminobutyric acid and ADDH
| Article | Year |
|---|---|
Neuroinflammation as a risk factor for attention deficit hyperactivity disorder.
Topics: Adolescent; Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System; Child; C | 2019 |
Sexual differentiation of the brain and ADHD: what is a sex difference in prevalence telling us?
Topics: Apoptosis; Attention Deficit Disorder with Hyperactivity; Brain; Dopamine; Female; gamma-Aminobutyri | 2012 |
Current concepts of abnormal motor disorder: an experimental model of attentional deficit disorder.
Topics: Amphetamine; Animals; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Avoidance | 1981 |
3 trials available for gamma-aminobutyric acid and ADDH
| Article | Year |
|---|---|
[The results of the pharmacological treatment of attention deficit hyperactivity disorder: evaluation with neuropsychological methods].
Topics: Attention; Attention Deficit Disorder with Hyperactivity; Child; Cognition; Female; GABA Agonists; g | 2014 |
Pregabalin increases slow-wave sleep and may improve attention in patients with partial epilepsy and insomnia.
Topics: Adolescent; Adult; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Cross-Over Studie | 2012 |
Divalproex sodium reduces overall aggression in youth at high risk for bipolar disorder.
Topics: Adolescent; Affect; Aggression; Antimanic Agents; Attention Deficit and Disruptive Behavior Disorder | 2006 |
31 other studies available for gamma-aminobutyric acid and ADDH
| Article | Year |
|---|---|
[Influence of pantogam and atomoxetine on attention stability and distribution of dopamine D2 and GABAB receptors in the attention deficit mouse model].
Topics: Animals; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Dopamine; gamma-A | 2021 |
Relationship between sleep problems and chronotypes of children and adolescents with attention deficit and hyperactivity disorder and serum GABA, glutamate and homocysteine levels.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Circadian Rhythm; gamma-Aminobutyr | 2022 |
The electroretinogram b-wave amplitude: a differential physiological measure for Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Child; C | 2022 |
Reduced Glx and GABA Inductions in the Anterior Cingulate Cortex and Caudate Nucleus Are Related to Impaired Control of Attention in Attention-Deficit/Hyperactivity Disorder.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Caudate Nucleus; gamma-Aminobutyric Acid; Geno | 2022 |
Cerebellar gamma-aminobutyric acid: Investigation of group effects in neurodevelopmental disorders.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Case-Control St | 2023 |
Reduced striatal GABA in unmedicated children with ADHD at 7T.
Topics: Attention Deficit Disorder with Hyperactivity; Cerebral Cortex; Child; Child, Preschool; Corpus Stri | 2020 |
Magnetic Resonance Spectroscopy of γ-Aminobutyric Acid and Glutamate Concentrations in Children With Attention-Deficit/Hyperactivity Disorder.
Topics: Adolescent; Adolescent Development; Attention Deficit Disorder with Hyperactivity; Brain; Brain Mapp | 2020 |
Relationship between GABA levels and task-dependent cortical excitability in children with attention-deficit/hyperactivity disorder.
Topics: Attention Deficit Disorder with Hyperactivity; Brain; Child; Cortical Excitability; Evoked Potential | 2021 |
Chronic Administrations of Guanfacine on Mesocortical Catecholaminergic and Thalamocortical Glutamatergic Transmissions.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Attention Deficit Disorder with Hyperactivity; Dopami | 2021 |
Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue.
Topics: Animals; Astrocytes; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Cell Communica | 2019 |
Evidence for reduced tonic levels of GABA in the hippocampus of an animal model of ADHD, the spontaneously hypertensive rat.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; Female; gamma-Aminob | 2013 |
Impulsivity and Aggression in Female BPD and ADHD Patients: Association with ACC Glutamate and GABA Concentrations.
Topics: Adult; Aggression; Attention Deficit Disorder with Hyperactivity; Borderline Personality Disorder; C | 2016 |
Impulsivity and Aggression in Female BPD and ADHD Patients: Association with ACC Glutamate and GABA Concentrations.
Topics: Adult; Aggression; Attention Deficit Disorder with Hyperactivity; Borderline Personality Disorder; C | 2016 |
Impulsivity and Aggression in Female BPD and ADHD Patients: Association with ACC Glutamate and GABA Concentrations.
Topics: Adult; Aggression; Attention Deficit Disorder with Hyperactivity; Borderline Personality Disorder; C | 2016 |
Impulsivity and Aggression in Female BPD and ADHD Patients: Association with ACC Glutamate and GABA Concentrations.
Topics: Adult; Aggression; Attention Deficit Disorder with Hyperactivity; Borderline Personality Disorder; C | 2016 |
Hyperactivity and impaired attention in Gamma aminobutyric acid transporter subtype 1 gene knockout mice.
Topics: Animals; Anxiety; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; DNA-Binding | 2015 |
Developmental changes in gamma-aminobutyric acid levels in attention-deficit/hyperactivity disorder.
Topics: Adolescent; Adolescent Development; Adult; Age Factors; Attention Deficit Disorder with Hyperactivit | 2015 |
Neuroligin-2 Expression in the Prefrontal Cortex is Involved in Attention Deficits Induced by Peripubertal Stress.
Topics: Animals; Attention; Attention Deficit Disorder with Hyperactivity; Cell Adhesion Molecules, Neuronal | 2016 |
Cadherin-13, a risk gene for ADHD and comorbid disorders, impacts GABAergic function in hippocampus and cognition.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Cadherins; Disease Models, Animal; gamma-Ami | 2015 |
Abuse of Gabapentin is Associated with Opioid Addiction.
Topics: Adult; Amines; Attention Deficit Disorder with Hyperactivity; Comorbidity; Criminals; Cyclohexanecar | 2016 |
Glutamatergic and GABAergic gene sets in attention-deficit/hyperactivity disorder: association to overlapping traits in ADHD and autism.
Topics: Adolescent; Amino Acid Transport System y+L; Attention Deficit Disorder with Hyperactivity; Autism S | 2017 |
Differentiating attention-deficit/hyperactivity disorder inattentive and combined types: a (1)H-magnetic resonance spectroscopy study of fronto-striato-thalamic regions.
Topics: Adolescent; Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Choline; Corpus Striatum; | 2009 |
[Attention-deficit hyperactivity disorder: determination of the optimal medical treatment duration].
Topics: Attention Deficit Disorder with Hyperactivity; Child; Drug Administration Schedule; Female; gamma-Am | 2011 |
Clozapine decreases exploratory activity and increases anxiety-like behaviour in the Wistar-Kyoto rat but not the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Anxiety; Attention Deficit Disorder with Hypera | 2012 |
Reduced GABA concentration in attention-deficit/hyperactivity disorder.
Topics: Attention Deficit Disorder with Hyperactivity; Brain; Child; Cross-Sectional Studies; Female; gamma- | 2012 |
Elevated plasma gamma-aminobutyric acid (GABA) levels in autistic youngsters: stimulus for a GABA hypothesis of autism.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Biomarkers; Child; Chi | 2002 |
[Models of drug treatment in the attention deficit disorder with hyperactivity].
Topics: Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Attention Deficit Disorder with Hyperac | 2002 |
Proton spectroscopy in medication-free pediatric attention-deficit/hyperactivity disorder.
Topics: Adolescent; Amino Acids; Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Basal Ganglia | 2003 |
Proton magnetic resonance spectroscopy and cognitive function in pediatric attention-deficit/hyperactive disorder.
Topics: Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Brain Stem; Child; Choline; Cognition | 2004 |
Neuroimaging of tic disorders with co-existing attention-deficit/hyperactivity disorder.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Brain; Brain Mapping; Caudate Nucleus; Ch | 2007 |
Gabapentin for behavioral dyscontrol.
Topics: Acetates; Adolescent; Amines; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Cycloh | 1995 |
Behavioral side effects of gabapentin in children.
Topics: Acetates; Aggression; Akathisia, Drug-Induced; Amines; Anticonvulsants; Attention Deficit Disorder w | 1996 |
Gabapentin and methylphenidate treatment of a preadolescent with attention deficit hyperactivity disorder and bipolar disorder.
Topics: Acetates; Amines; Antimanic Agents; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; | 2001 |
[Role of biogenic amines in the pathogenesis of intellectual disorders in children with minimal psychoorganic syndromes].
Topics: Attention Deficit Disorder with Hyperactivity; Catecholamines; Child; Dihydroxyphenylalanine; Electr | 1978 |