gambogic-acid and Leukemia--Myeloid

gambogic-acid has been researched along with Leukemia--Myeloid* in 1 studies

Other Studies

1 other study(ies) available for gambogic-acid and Leukemia--Myeloid

Article	Year
Gambogic acid induces G0/G1 arrest and apoptosis involving inhibition of SRC-3 and inactivation of Akt pathway in K562 leukemia cells. Toxicology, 2009, Aug-03, Volume: 262, Issue:2 Gambogic acid (GA), a major active component of gamboge, exhibits potent anticancer activity in many kinds of cancer cells. However, the anticancer mechanism of GA is not clearly understood. Here we showed that GA could cause growth inhibition, induce the G0/G1 phase cell cycle arrest and apoptosis in human chronic myelogenous leukemia cell line K562 cells. Since steroid receptor coactivator-3 (SRC-3), overexpressed in many human malignancies including leukemia, is a central target for cancer therapy, we also explored the effects of GA on SRC-3 and SRC-3-regulated gene products in K562. GA treatment downregulated the expression of SRC-3 and then inhibited the activity of Akt kinase and its downstream targets p70 S6 kinase 1 (S6K1) and glycogen synthase kinase 3beta (GSK3beta) without changes in total protein levels of these three proteins, which thus influenced the expression of the apoptosis related gene Bcl-2 in K562 cells. These results suggest that GA might exhibit its strong antitumor effects via the interruption of SRC-3. Topics: Antineoplastic Agents; Apoptosis; Cell Nucleus; Cell Proliferation; Cell Survival; Down-Regulation; Drug Screening Assays, Antitumor; Gene Expression; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Histone Acetyltransferases; Humans; Interphase; K562 Cells; Leukemia, Myeloid; Nuclear Receptor Coactivator 3; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Trans-Activators; Xanthones	2009

Article

Year

Gambogic acid induces G0/G1 arrest and apoptosis involving inhibition of SRC-3 and inactivation of Akt pathway in K562 leukemia cells.

Toxicology, 2009, Aug-03, Volume: 262, Issue:2

Gambogic acid (GA), a major active component of gamboge, exhibits potent anticancer activity in many kinds of cancer cells. However, the anticancer mechanism of GA is not clearly understood. Here we showed that GA could cause growth inhibition, induce the G0/G1 phase cell cycle arrest and apoptosis in human chronic myelogenous leukemia cell line K562 cells. Since steroid receptor coactivator-3 (SRC-3), overexpressed in many human malignancies including leukemia, is a central target for cancer therapy, we also explored the effects of GA on SRC-3 and SRC-3-regulated gene products in K562. GA treatment downregulated the expression of SRC-3 and then inhibited the activity of Akt kinase and its downstream targets p70 S6 kinase 1 (S6K1) and glycogen synthase kinase 3beta (GSK3beta) without changes in total protein levels of these three proteins, which thus influenced the expression of the apoptosis related gene Bcl-2 in K562 cells. These results suggest that GA might exhibit its strong antitumor effects via the interruption of SRC-3.

Topics: Antineoplastic Agents; Apoptosis; Cell Nucleus; Cell Proliferation; Cell Survival; Down-Regulation; Drug Screening Assays, Antitumor; Gene Expression; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Histone Acetyltransferases; Humans; Interphase; K562 Cells; Leukemia, Myeloid; Nuclear Receptor Coactivator 3; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Trans-Activators; Xanthones

2009