gambierol and Disease-Models--Animal

Gambierol was isolated from Gambierdiscus toxicus, which causes ciguatera fish poisoning. The acute toxicological effects induced in mice by synthesized gambierol were studied. The lethal doses were about 80 microg/kg by i.p. and i.v., and 150 microg/kg by p.o. The main injury by this toxin was observed in the lung, and secondary in the heart, resulting in systemic congestion. Another toxic effect was seen in the stomach, inducing hypersecretion and ulceration. With survival from the severe stage during the initial 3 h, recovery was favorable, especially after 4 days. Additional effects were not evident during 1-week post-administration observation.

Topics: Administration, Oral; Animals; Ciguatera Poisoning; Ciguatoxins; Dinoflagellida; Disease Models, Animal; Ethers, Cyclic; Injections, Intraperitoneal; Injections, Intravenous; Lethal Dose 50; Lung; Male; Mice; Mice, Inbred ICR; Myocardium; Polycyclic Compounds; Stomach