gallium-maltolate and Glioblastoma

gallium-maltolate has been researched along with Glioblastoma* in 1 studies

Other Studies

1 other study(ies) available for gallium-maltolate and Glioblastoma

Article	Year
Gallium Maltolate Disrupts Tumor Iron Metabolism and Retards the Growth of Glioblastoma by Inhibiting Mitochondrial Function and Ribonucleotide Reductase. Molecular cancer therapeutics, 2018, Volume: 17, Issue:6 Gallium, a metal with antineoplastic activity, binds transferrin (Tf) and enters tumor cells via Tf receptor1 (TfR1); it disrupts iron homeostasis leading to cell death. We hypothesized that TfR1 on brain microvascular endothelial cells (BMEC) would facilitate Tf-Ga transport into the brain enabling it to target TfR-bearing glioblastoma. We show that U-87 MG and D54 glioblastoma cell lines and multiple glioblastoma stem cell (GSC) lines express TfRs, and that their growth is inhibited by gallium maltolate (GaM) Topics: Animals; Antineoplastic Agents; Brain; Cell Line, Tumor; Disease Models, Animal; Glioblastoma; Heterografts; Humans; Immunohistochemistry; Iron; Male; Mitochondria; Organometallic Compounds; Pyrones; Rats; Receptors, Transferrin; Ribonucleoside Diphosphate Reductase; Ribonucleotide Reductases	2018

Article

Year

Gallium Maltolate Disrupts Tumor Iron Metabolism and Retards the Growth of Glioblastoma by Inhibiting Mitochondrial Function and Ribonucleotide Reductase.

Molecular cancer therapeutics, 2018, Volume: 17, Issue:6

Gallium, a metal with antineoplastic activity, binds transferrin (Tf) and enters tumor cells via Tf receptor1 (TfR1); it disrupts iron homeostasis leading to cell death. We hypothesized that TfR1 on brain microvascular endothelial cells (BMEC) would facilitate Tf-Ga transport into the brain enabling it to target TfR-bearing glioblastoma. We show that U-87 MG and D54 glioblastoma cell lines and multiple glioblastoma stem cell (GSC) lines express TfRs, and that their growth is inhibited by gallium maltolate (GaM)

Topics: Animals; Antineoplastic Agents; Brain; Cell Line, Tumor; Disease Models, Animal; Glioblastoma; Heterografts; Humans; Immunohistochemistry; Iron; Male; Mitochondria; Organometallic Compounds; Pyrones; Rats; Receptors, Transferrin; Ribonucleoside Diphosphate Reductase; Ribonucleotide Reductases

2018