gallium-ga-68-dotatate and Urinary-Bladder-Neoplasms

We report a case of an adult male patient with multifocal urinary bladder paragangliomas, which were negative on Ga-DOTATATE PET/CT scan, but positive on I-MIBG SPECT/CT scan. While the Ga-DOTA analog PET/CT exhibits superior performance in diagnosis and staging of pheochromocytoma and paraganglioma, our case demonstrates negative somatostatin receptor expression in this rare entity and indicates that I-MIBG SPECT/CT still plays a vital role in characterization of bladder paraganglioma.

Topics: 3-Iodobenzylguanidine; Biological Transport; Humans; Male; Middle Aged; Organometallic Compounds; Paraganglioma; Positron Emission Tomography Computed Tomography; Receptors, Somatostatin; Urinary Bladder Neoplasms

Paragangliomas of the urinary bladder are very rare. They are extra-adrenal autonomic nervous system tumors. This report presents a case of a 13-year-old boy with urinary bladder paraganglioma and the role of somatostatin receptor imaging with simultaneous positron emission tomography magnetic resonance (PET/MR). We have also described appearances of iodine-123 metaiodobenzylguanidine ((123)I-MIBG) single photon emission computed tomography (SPECT/CT) in comparison to somatostatin receptor imaging.

Topics: 3-Iodobenzylguanidine; Adolescent; Humans; Magnetic Resonance Imaging; Male; Multimodal Imaging; Organometallic Compounds; Paraganglioma; Radiopharmaceuticals; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; Urinary Bladder Neoplasms