gallium-ga-68-dotatate and Sarcoidosis

gallium-ga-68-dotatate has been researched along with Sarcoidosis* in 4 studies

Other Studies

4 other study(ies) available for gallium-ga-68-dotatate and Sarcoidosis

ArticleYear
Feasibility of somatostatin receptor-targeted imaging for detection of myocardial inflammation: A pilot study.
    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2021, Volume: 28, Issue:3

    Gallium-68 Dotatate binds preferentially to somatostatin receptor (sstr) subtype-2 (sstr-2) on inflammatory cells. We aimed at investigating the potential clinical use of sstr-targeted imaging for the detection of myocardial inflammation.. Thirteen patients, with suspected cardiac sarcoidosis (CS) based on clinical history and myocardial uptake on recent fluorine-18 fluorodeoxyglucose (FDG) PET, were enrolled to undergo Dotatate PET after FDG-PET (median time 37 days [IQR 25-55]). Additionally, we investigated ex-vivo the immunohistochemistry expression of sstr-2 in 3 explanted sarcoid hearts.. All FDG scans showed cardiac uptake (focal/multifocal = 6, focal on diffuse/heterogeneous = 7), and 46% (n = 6) extra-cardiac uptake (mediastinal/hilar). In comparison, Dotatate scans showed definite abnormal cardiac uptake (focal/multifocal) in 4 patients, probably abnormal (heterogenous/patchy) in 3, and negative uptake in 6 cases. Similarly, 6 patients had increased mediastinal/hilar Dotatate uptake. Overall concordance of FDG and Dotatate uptake was 54% in the heart and 100% for thoracic nodal activity. Quantitatively, FDG maximum standardized uptake value was 5.0 times [3.8-7.1] higher in the heart, but only 2.25 times [1.7-3.0; P = .019] higher in thoracic nodes relative to Dotatate. Ex-vivo, sstr-2 immunostaining was weakly seen within well-formed granulomas in all 3 examined sarcoid heart specimens with no significant staining of background myocardium or normal myocardium.. Our preliminary data suggest that, compared to FDG imaging, somatostatin receptor-targeted imaging may be less sensitive for the detection of myocardial inflammation, but comparable for detecting extra-cardiac inflammation.

    Topics: Aged; Feasibility Studies; Female; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Myocarditis; Organometallic Compounds; Pilot Projects; Positron Emission Tomography Computed Tomography; Prospective Studies; Radiopharmaceuticals; Receptors, Somatostatin; Sarcoidosis; Sensitivity and Specificity

2021
Somatostatin receptor imaging in active cardiac sarcoidosis: Would less be enough?
    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2021, Volume: 28, Issue:3

    Topics: Fluorodeoxyglucose F18; Humans; Myocarditis; Organometallic Compounds; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals; Receptors, Somatostatin; Sarcoidosis; Sensitivity and Specificity

2021
Teaching NeuroImages: Advanced imaging of neurosarcoidosis with
    Neurology, 2019, 05-21, Volume: 92, Issue:21

    Topics: Brain; Central Nervous System Diseases; Humans; Macrophages; Male; Middle Aged; Organometallic Compounds; Positron Emission Tomography Computed Tomography; Sarcoidosis

2019
The utility of PET/CT with (68)Ga-DOTATOC in sarcoidosis: comparison with (67)Ga-scintigraphy.
    Annals of nuclear medicine, 2016, Volume: 30, Issue:8

    This study was designed to compare the clinical efficacy of (68)Ga-DOTA-Tyr-octreotide (DOTATOC)-positron emission tomography (PET)/computed tomography (CT) with that of conventional (67)Ga-scintigraphy (GS), and to correlate quantitative parameters on DOTATOC-PET/CT with clinical data, in patients with sarcoidosis.. Twenty patients who were histologically and/or clinically diagnosed with sarcoidosis and underwent both DOTATOC-PET/CT and GS were analyzed in this study. The numbers of patients with positive findings for each organ were determined. The total numbers of involved nodal areas in the chest, as determined by DOTATOC-PET and gallium single-photon emission tomography (Ga-SPECT), were compared. The correlations between quantitative parameters on PET and clinical laboratory data were evaluated.. DOTATOC-PET/CT was positive in 19 patients, being negative in only one patient with chronic inactive sarcoidosis, whereas GS was positive in 17 patients. DOTATOC-PET/CT visualized more lesions in lymph nodes, uvea, and muscles than did Ga-scintigraphy and identified more involved areas than did GS-SPECT (p < 0.0001). Whole-body active lesion volume showed a significant, but moderate correlation with angiotensin-converting enzyme level (ρ = 0.64, p = 0.0044).. PET/CT with DOTATOC may be superior to conventional GS in detecting sarcoidosis lesions, especially in lymph nodes, uvea, and muscles. Volumetric parameters in DOTATOC-PET/CT may be helpful in estimating the activity of sarcoidosis.

    Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Organometallic Compounds; Positron Emission Tomography Computed Tomography; Sarcoidosis

2016