gallium-ga-68-dotatate and Prostatic-Neoplasms

Topics: Aged, 80 and over; Asymptomatic Infections; Child, Preschool; China; COVID-19; COVID-19 Nucleic Acid Testing; Edetic Acid; Female; Gallium Isotopes; Gallium Radioisotopes; Humans; Hypoglycemia; Incidental Findings; Male; Neuroendocrine Tumors; Oligopeptides; Organometallic Compounds; Polymerase Chain Reaction; Positron Emission Tomography Computed Tomography; Prostatic Neoplasms; Radiography, Thoracic; Sensitivity and Specificity

A 69-year-old man with history of metastatic neuroendocrine tumor presented for initial staging with 68Ga-DOTATE PET/CT. 68Ga-DOTATATE PET/CT showed incidental focal increased DOTATATE uptake in the left apical prostate tissue, which was thought to be of benign etiology. Digital rectal examination later was consistent with a palpable nodule along with elevated prostate-specific antigen of 7.0 ng/mL. MRI of prostate demonstrated a 3.8-cm lesion followed by a targeted biopsy that revealed prostatic acinar adenocarcinoma. Chronic inflammatory cell infiltrates were also noted on biopsy, and this may have been the cause of increased DOTATATE uptake seen on 68Ga-DOTATATE PET/CT study.

Topics: Aged; Biological Transport; Biopsy; Carcinoma, Acinar Cell; Humans; Incidental Findings; Liver Neoplasms; Male; Neuroendocrine Tumors; Organometallic Compounds; Positron Emission Tomography Computed Tomography; Prostate; Prostatic Neoplasms

Prostate large cell neuroendocrine tumor is a rare disease. In this case, metastatic areas showing FDG uptake, somatostatin receptor positivity, and PSMA expression are shown in F-FDG PET/CT, Ga-DOTATATE PET/CT, and Ga-PSMA PET/CT in a 70-year-old man with the diagnosis of prostate large cell neuroendocrine carcinoma.

Topics: Aged; Edetic Acid; Fluorodeoxyglucose F18; Gallium Isotopes; Gallium Radioisotopes; Humans; Male; Neoplasm Metastasis; Neuroendocrine Tumors; Oligopeptides; Organometallic Compounds; Positron Emission Tomography Computed Tomography; Prostatic Neoplasms; Radiopharmaceuticals

A 71-year-old man with history of prostate cancer is evaluated for rising prostate-specific antigen. The patient also has a history of rectal well-differentiated neuroendocrine tumor. On F-fluciclovine PET/CT, 2 retroperitoneal lymph nodes exhibited intense fluciclovine avidity, whereas one enlarged perirectal lymph node only showed background uptake. On further Ga-DOTATATE PET/CT, the perirectal lymph node revealed intense DOTATATE avidity, whereas the 2 retroperitoneal lymph nodes only with similar to background DOTATATE avidity. Biopsy of the perirectal lymph node confirmed metastasis from neuroendocrine tumor. The distinct imaging characteristics of metastases from different primary malignancies correlated with their underlying different pathology.

Topics: Adenocarcinoma; Aged; Carboxylic Acids; Carcinoid Tumor; Cyclobutanes; Humans; Intestinal Neoplasms; Male; Neoplasm Metastasis; Organometallic Compounds; Positron Emission Tomography Computed Tomography; Prostatic Neoplasms; Radiopharmaceuticals; Rectal Neoplasms

Topics: Aged; Humans; Male; Multimodal Imaging; Neoplasm Staging; Organometallic Compounds; Positron-Emission Tomography; Prostatic Neoplasms; Receptors, Somatostatin; Tomography, X-Ray Computed