gallium-ga-68-dotatate and Nasopharyngeal-Neoplasms

In this case of suspected sphenoid wing meningioma, Ga-DOTATATE PET/CT showed a somatostatin receptor (SSR)-expressing tumor with extension to the nasopharynx and SSR-expressing cervical lymph nodes. Subsequent biopsy from the nasopharynx revealed an Epstein-Barr virus (EBV)-associated, undifferentiated World Health Organization type 3 nasopharyngeal carcinoma (NPC), a potential clinical pitfall due to the reported high SSR expression of this tumor subtype. In consideration of the high target-to-background contrast, SSR ligands might be superior to F-FDG for EBV-associated NPC PET imaging, particularly at the skull base. Somatostatin receptor ligands might furthermore offer interesting theranostic possibilities for patients with advanced/extensive EBV-associated NPC.

Topics: Adult; Carcinoma; Herpesvirus 4, Human; Humans; Male; Meningeal Neoplasms; Meningioma; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Organometallic Compounds; Positron Emission Tomography Computed Tomography

Topics: Abdominal Neoplasms; Carcinoma, Squamous Cell; Diagnosis, Differential; Fluorodeoxyglucose F18; Head and Neck Neoplasms; Humans; Male; Middle Aged; Nasopharyngeal Neoplasms; Neoplasms, Multiple Primary; Organometallic Compounds; Paraganglioma; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals; Squamous Cell Carcinoma of Head and Neck; Tissue Distribution

Solitary fibrous tumors (SFTs) are rare group of mesenchymal tumors that occurs predominantly in the pleura. The role of PET/CT imaging in characterizing the SFT is not well reported. Mesenchymal tumors may express somatostatin receptors. We hereby report a rare case of SFT of the nasopharynx showing Ga DOTATATE avidity.

Topics: Adult; Female; Humans; Multimodal Imaging; Nasopharyngeal Neoplasms; Organometallic Compounds; Positron-Emission Tomography; Radiopharmaceuticals; Solitary Fibrous Tumors; Tomography, X-Ray Computed