gallium-ga-68-dotatate and Multiple-Pulmonary-Nodules

gallium-ga-68-dotatate has been researched along with Multiple-Pulmonary-Nodules* in 2 studies

Trials

1 trial(s) available for gallium-ga-68-dotatate and Multiple-Pulmonary-Nodules

ArticleYear
68Ga-DOTATATE PET/CT imaging of indeterminate pulmonary nodules and lung cancer.
    PloS one, 2017, Volume: 12, Issue:2

    18F-FDG PET/CT is widely used to evaluate indeterminate pulmonary nodules (IPNs). False positive results occur, especially from active granulomatous nodules. A PET-based imaging agent with superior specificity to 18F-FDG for IPNs, is badly needed, especially in areas of endemic granulomatous nodules. Somatostatin receptors (SSTR) are expressed in many malignant cells including small cell and non-small cell lung cancers (NSCLCs). 68Ga-DOTATATE, a positron emitter labeled somatostatin analog, combined with PET/CT imaging, may improve the diagnosis of IPNs over 18F-FDG by reducing false positives. Our study purpose was to test this hypothesis in our region with high endemic granulomatous IPNs.. We prospectively performed 68Ga-DOTATATE PET/CT and 18F-FDG PET/CT scans in the same 30 patients with newly diagnosed, treatment-naïve lung cancer (N = 14) or IPNs (N = 15) and one metastatic nodule. 68Ga-DOTATATE SUVmax levels at or above 1.5 were considered likely malignant. We analyzed the scan results, correlating with ultimate diagnosis via biopsy or 2-year chest CT follow-up. We also correlated 68Ga-DOTATATE uptake with immunohistochemical (IHC) staining for SSTR subtype 2A (SSTR2A) in pathological specimens.. We analyzed 31 lesions in 30 individuals, with 14 (45%) being non-neuroendocrine lung cancers and 1 (3%) being metastatic disease. McNemar's result comparing the two radiopharmaceuticals (p = 0.65) indicates that their accuracy of diagnosis in this indication are equivalent. 68Ga-DOTATATE was more specific (94% compared to 81%) and less sensitive 73% compared to 93%) than 18F-FDG. 68Ga-DOTATATE uptake correlated with SSTR2A expression in tumor stroma determined by immunohistochemical (IHC) staining in 5 of 9 (55%) NSCLCs.. 68Ga-DOTATATE and 18F-FDG PET/CT had equivalent accuracy in the diagnosis of non-neuroendocrine lung cancer and 68Ga-DOTATATE was more specific than 18F-FDG for the diagnosis of IPNs. IHC staining for SSTR2A receptor expression correlated with tumor stroma but not tumor cells.

    Topics: Adult; Aged; Biopsy; Carcinoma, Non-Small-Cell Lung; Diagnosis, Differential; Female; Humans; Lung Neoplasms; Male; Middle Aged; Multimodal Imaging; Multiple Pulmonary Nodules; Neoplasm Metastasis; Organometallic Compounds; Positron Emission Tomography Computed Tomography

2017

Other Studies

1 other study(ies) available for gallium-ga-68-dotatate and Multiple-Pulmonary-Nodules

ArticleYear
Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia on Somatostatin Receptor Imaging.
    American journal of respiratory and critical care medicine, 2018, 11-01, Volume: 198, Issue:9

    Topics: Aged; Biopsy; Carcinoid Tumor; Diagnosis, Differential; Female; Humans; Hyperplasia; Lung; Lung Neoplasms; Multiple Pulmonary Nodules; Neuroendocrine Cells; Organometallic Compounds; Positron Emission Tomography Computed Tomography; Receptors, Somatostatin

2018