gallium-ga-68-dotatate and Leiomyosarcoma

We report the case of a 58-year-old man with mesenteric nodule at CT performed for abdominal pain. In the suspicion of neoplastic disease, he underwent 18F-FDG PET/CT that did not show abnormal uptake. The nodule was monitored alternating CT and MRI. Two years after the first detection, MRI revealed an increase in size, and 18F-FDG PET/CT was repeated for metabolic evaluation, showing increased metabolic activity. In suspicion of neuroendocrine tumor, for anatomical site, slow growth, and clinical symptoms, 68Ga-DOTATOC PET/CT was performed showing focal uptake, indicating high expression of somatostatin receptors. The final pathology report was consistent with high-grade leiomyosarcoma.

Topics: Abdominal Neoplasms; Fluorodeoxyglucose F18; Humans; Leiomyosarcoma; Magnetic Resonance Imaging; Male; Middle Aged; Organometallic Compounds; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography

Carney triad is a very rare syndrome characterized by the synchronous or metachronous occurrence of gastrointestinal stromal tumors, pulmonary chondroma, and extra-adrenal paraganglioma. We present the case of a 36-year-old woman with complete Carney triad who underwent a Ga-DOTA-TATE PET/CT scan for restaging of metastasizing extra-adrenal paraganglioma and for evaluation of targeted radionuclide therapy potential. On the Ga-DOTA-TATE PET scan, increased tracer accumulation was observed in paraganglioma metastases. This case highlights the usefulness of Ga-DOTA-TATE PET/CT for restaging of metastasizing paraganglioma in Carney triad and the option of targeted radionuclide therapy in this entity.

Topics: Adult; Chondroma; Female; Gene Expression Regulation, Neoplastic; Humans; Leiomyosarcoma; Lung Neoplasms; Organometallic Compounds; Paraganglioma, Extra-Adrenal; Positron Emission Tomography Computed Tomography; Receptors, Somatostatin; Stomach Neoplasms