gallium-ga-68-dotatate and Esthesioneuroblastoma--Olfactory

Esthesioneuroblastoma is a rare malignant tumor arising from olfactory neuroepithelium. PET/CT with different tracers such as 18F-FDG and 68Ga-somatostatin-receptor tracers has demonstrated its utility for the evaluation of disease. We present the case of a woman previously treated for esthesioneuroblastoma performing MR and 18Ga-DOTATOC PET/CT demonstrating dural metastasis of disease with a strong correspondence between conventional and functional imaging.

Topics: Esthesioneuroblastoma, Olfactory; Female; Humans; Meningeal Carcinomatosis; Middle Aged; Nasal Cavity; Nose Neoplasms; Organometallic Compounds; Positron Emission Tomography Computed Tomography

We present a 48-year-old woman with an olfactory neuroblastoma who was referred for accurate staging using PET/CT. The Ga-DOTATATE PET/CT showed a 51 × 32-mm mass with an SUVmax of 7.59 in the sphenoidal sinuses, whereas radiotracer uptake on F-FDG PET/CT was similar to that of brain tissue. Ga-DOTATATE PET/CT might be especially useful in regions with difficult tumor visualization resulting from high background, such as brain tissue. The results of this case may suggest that somatostatin receptor imaging in patients with esthesioneuroblastoma may facilitate the potential application of radiotheranostic agents for the treatment of this aggressive subtype of tumors.

Topics: Esthesioneuroblastoma, Olfactory; Female; Fluorodeoxyglucose F18; Humans; Middle Aged; Nasal Cavity; Nose Neoplasms; Organometallic Compounds; Positron Emission Tomography Computed Tomography; Receptors, Somatostatin