gallium-ga-68-dotatate and Abdominal-Neoplasms

We report the case of a 58-year-old man with mesenteric nodule at CT performed for abdominal pain. In the suspicion of neoplastic disease, he underwent 18F-FDG PET/CT that did not show abnormal uptake. The nodule was monitored alternating CT and MRI. Two years after the first detection, MRI revealed an increase in size, and 18F-FDG PET/CT was repeated for metabolic evaluation, showing increased metabolic activity. In suspicion of neuroendocrine tumor, for anatomical site, slow growth, and clinical symptoms, 68Ga-DOTATOC PET/CT was performed showing focal uptake, indicating high expression of somatostatin receptors. The final pathology report was consistent with high-grade leiomyosarcoma.

Topics: Abdominal Neoplasms; Fluorodeoxyglucose F18; Humans; Leiomyosarcoma; Magnetic Resonance Imaging; Male; Middle Aged; Organometallic Compounds; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography

Pheochromocytomas/paragangliomas are somatostatin receptor 2-overexpressing tumors. Ga-DOTA-peptide imaging has recently shown excellent results in the detection of metastatic lesions in these tumors. However, currently used Ga-DOTA peptides show different somatostatin receptor affinities. Here, we report the remarkable differences in a patient who was imaged with Ga-DOTANOC and Ga-DOTATATE PET/CT within a 7-month period. The patient presented with a nearly negative Ga-DOTANOC PET/CT scan, whereas on Ga-DOTATATE PET/CT, multiple highly positive lesions were identified.

Topics: Abdominal Neoplasms; Child; Female; Humans; Lung Neoplasms; Neoplasm Metastasis; Organometallic Compounds; Paraganglioma; Positron Emission Tomography Computed Tomography; Protein Binding; Radiopharmaceuticals; Receptors, Somatostatin; Succinate Dehydrogenase

Topics: Abdominal Neoplasms; Carcinoma, Squamous Cell; Diagnosis, Differential; Fluorodeoxyglucose F18; Head and Neck Neoplasms; Humans; Male; Middle Aged; Nasopharyngeal Neoplasms; Neoplasms, Multiple Primary; Organometallic Compounds; Paraganglioma; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals; Squamous Cell Carcinoma of Head and Neck; Tissue Distribution

Topics: Abdominal Neoplasms; Feasibility Studies; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Organometallic Compounds; Paraganglioma; Positron-Emission Tomography; Radiopharmaceuticals; Soft Tissue Neoplasms