gallic acid has been researched along with Disease Models, Animal in 119 studies
gallate : A trihydroxybenzoate that is the conjugate base of gallic acid.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
Excerpt | Relevance | Reference |
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"This study investigated the ameliorative effect of gallic acid (GA) on hypertriglyceridemia and fat accumulation in perirenal adipose tissues of high-fructose diet (HFD)-induced diabetic rats." | 7.88 | Gallic Acid Alleviates Hypertriglyceridemia and Fat Accumulation via Modulating Glycolysis and Lipolysis Pathways in Perirenal Adipose Tissues of Rats Fed a High-Fructose Diet. ( Chang, WC; Huang, DW; Shen, SC; Wu, JS; Yang, HJ, 2018) |
" The present study was intended to appraise the nutraceutical inherent of HPLC standardized Spinacia oleracea methanolic leaf extract (SoLE) in isoproterenol (ISO) induced male albino Wistar rats via activation of pro-inflammatory signaling pathway that drives myocardial necrosis." | 7.85 | Nutraceutical inherent of Spinacia oleracea Linn. methanolic leaf extract ameliorates isoproterenol induced myocardial necrosis in male albino Wistar rats via mitigating inflammation. ( Jolapuram, U; Kodidhela, LD; Vutharadhi, S, 2017) |
"In the relevant literature, there is no experimental study that investigated the axon protective effects of syringic acid- a polyphenol compound- with an anti-oxidant capacity on ischemia/reperfusion injury." | 7.85 | The Axon Protective Effects of Syringic Acid on Ischemia/Reperfusion Injury in a Rat Sciatic Nerve Model. ( Akman, T; Albayrak, SB; Aras, AB; Cosar, M; Gomleksiz, C; Guven, M; Sehitoglu, MH; Tokmak, M; Yaka, U; Yuksel, Y, 2017) |
"Administration of leonurine (60 mg/kg) for 4 weeks significantly alleviated depression-like behaviors of chronic mild stress mice, including increased sucrose preference and reduced immobility time in forced swimming test and tail suspension test." | 7.85 | Leonurine Exerts Antidepressant-Like Effects in the Chronic Mild Stress-Induced Depression Model in Mice by Inhibiting Neuroinflammation. ( Chen, M; Ding, J; Ding, X; Du, R; Hu, G; Jia, M; Li, C; Lu, M; Zheng, Y, 2017) |
"These findings suggest that leonurine ameliorates cognitive dysfunction at least partly via antagonizing excitotoxic glutamate insults and inhibiting autophagy." | 7.83 | Leonurine ameliorates cognitive dysfunction via antagonizing excitotoxic glutamate insults and inhibiting autophagy. ( Gao, J; Liu, C; Xu, X; Yang, Z; Yin, H; Zhang, T, 2016) |
"Combined administration of gigantol and SA synergize to enhance anti-cataract efficacy." | 7.83 | Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract. ( Chen, CY; Chen, D; Fang, H; Gao, X; Li, X; Long, Y; Wei, X; Wu, J; Yi, Y, 2016) |
"Chronic treatment with trimethylgallic acid esters for 15 days significantly reversed the chronic stress-induced behavioral (impaired locomotor activity, anxiety-like behavior, and decreased percentage of memory retention), biochemical (increased lipid peroxidation and nitrite levels; decreased glutathione levels, superoxide dismutase and catalase activities), and inflammation surge (serum TNF-α) in stressed mice." | 7.80 | Effect of trimethylgallic acid esters against chronic stress-induced anxiety-like behavior and oxidative stress in mice. ( Chadha, R; Dhingra, MS; Dhingra, S; Karan, M; Kumar, A; Kumria, R; Singh, T, 2014) |
"Leonurine significantly alleviated neurological deficit, decreased brain water content and infarct volume after ischemic stroke, which was accompanied by decreased levels of MDA and Bax, increased activities of SOD, CAT, UCP4, and Bcl-2, and restored ultrastructure of mitochondria." | 7.78 | Leonurine protects brain injury by increased activities of UCP4, SOD, CAT and Bcl-2, decreased levels of MDA and Bax, and ameliorated ultrastructure of mitochondria in experimental stroke. ( Cao, X; Dong, L; Du, Y; Ji, H; Ji, Y; Li, L; Li, S; Liu, H; Wang, C; Xing, Y; Zhang, X; Zhao, K, 2012) |
" This study was designed to evaluate the protective effect of gallic acid on cardiac marker enzymes, troponin-T, LDH-isoenzyme pattern, lipid peroxidation products and antioxidant status in isoproterenol (ISO)-induced myocardial infarction in male Wistar rats." | 7.75 | Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats. ( Prince, PS; Priscilla, DH, 2009) |
"Leonurine treatment significantly inhibited the mortality caused by H1N1 infection." | 5.62 | Leonurine protects against influenza A virus infection-induced pneumonia in mice. ( Chen, XJ; Luo, YJ; Qiu, LN; Tan, YR, 2021) |
"Octyl gallate (OG) is a phenolic compound with therapeutic actions namely antimicrobial, antiviral, and antifungal." | 5.56 | Anti-inflammatory effect of octyl gallate in alveolar macrophages cells and mice with acute lung injury. ( Antunes, GL; da Costa, MS; de Oliveira, JR; de Souza Basso, B; Donadio, MVF; Gracia-Sancho, J; Haute, GV; Kaiber, DB; Levorse, VGS; Luft, C; Silveira, JS, 2020) |
"Gastric ulcers were induced by absolute ethanol (5 mL/kg, i." | 5.56 | Gastroprotective effect of gallic acid against ethanol-induced gastric ulcer in rats: Involvement of the Nrf2/HO-1 signaling and anti-apoptosis role. ( Chang, Y; Duan, LR; Li, H; Li, Y; Tian, T; Wang, SW; Yang, Q; Zhou, D, 2020) |
"Gallic acid is an active phenolic acid widely distributed in plants, and there is compelling evidence to prove its anti-inflammatory effects." | 5.56 | Gallic Acid Alleviates Gouty Arthritis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling. ( Chen, D; Fu, Z; Huang, X; Li, X; Li, Y; Lin, Y; Liu, A; Luo, T; Pan, H; Weng, A; Yao, Y, 2020) |
"cholerae was studied by performing histology in Swiss albino mice." | 5.51 | In vivo fluid accumulation-inhibitory, anticolonization and anti-inflammatory and in vitro biofilm-inhibitory activities of methyl gallate isolated from Terminalia chebula against fluoroquinolones resistant Vibrio cholerae. ( Acharyya, S; Bag, PK; Bhowmik, P; Koley, H; Roy, N; Saha, DR; Sarkar, P, 2019) |
"However, the effects of GA on ulcerative colitis (UC) remain unknown." | 5.51 | Gallic acid improved inflammation via NF-κB pathway in TNBS-induced ulcerative colitis. ( Gu, P; Shen, H; Zhu, L, 2019) |
"Neurodegenerative diseases comprise demyelination and synaptic loss." | 5.51 | Gallic and vanillic acid suppress inflammation and promote myelination in an in vitro mouse model of neurodegeneration. ( Jamali, KS; Kamal, A; Khan, F; Saify, ZS; Siddiqui, S, 2019) |
" The QUIN is involved in the development of several toxic cascades which leads to the neuronal degeneration processes." | 5.48 | Effect of wedelolactone and gallic acid on quinolinic acid-induced neurotoxicity and impaired motor function: significance to sporadic amyotrophic lateral sclerosis. ( Goli, D; S, M; T, P, 2018) |
"Endometritis is the inflammation of the endometrium that is associated with lower conception rates, increased intervals from calving to first service, and more culls for failure to conceive, which leads to serious economic losses in the dairy industry." | 5.48 | Leonurine ameliorates the inflammatory responses in lipopolysaccharide-induced endometritis. ( Chen, X; Dai, A; Deng, G; Huang, C; Jiang, K; Li, X; Wu, H; Yang, X, 2018) |
"Leonurine is a compound derived from Herba leonuri, which has been reported to protect cardiac tissue against ischemic injury via antioxidant and anti‑apoptosis effects." | 5.48 | Leonurine protects cardiac function following acute myocardial infarction through anti‑apoptosis by the PI3K/AKT/GSK3β signaling pathway. ( Jiang, X; Wei, F; Xu, L; Zhu, H, 2018) |
"Cardiac hypertrophy was induced by isoproterenol (ISP) in mice and primary neonatal cardiomyocytes." | 5.43 | Gallic acid prevents isoproterenol-induced cardiac hypertrophy and fibrosis through regulation of JNK2 signaling and Smad3 binding activity. ( Cho, JY; Choi, SY; Jeong, MH; Jin, L; Kee, HJ; Kim, GR; Lin, MQ; Piao, ZH; Ryu, Y, 2016) |
"Gallic acid (GA) is a polyhydroxy phenolic compound that has been detected in various natural products, such as green tea, strawberries, grapes, bananas, and many other fruits." | 5.42 | Gallic acid attenuates dextran sulfate sodium-induced experimental colitis in BALB/c mice. ( Looi, CY; Mohebali, N; Norhaizan, ME; Pandurangan, AK, 2015) |
"Fibrosis is one of the characteristic features of chronic kidney disease (CKD)." | 5.42 | Leonurine ameliorates kidney fibrosis via suppressing TGF-β and NF-κB signaling pathway in UUO mice. ( Bo, Y; Cheng, H; Jia, Z; Li, F; Shen, W; Tan, J; Xu, C, 2015) |
"Hypertension was induced in adult male albino rats by oral administration of L-NAME (40 mg/kg/day) dissolved in drinking water daily for 4 weeks." | 5.38 | Syringic acid ameliorates (L)-NAME-induced hypertension by reducing oxidative stress. ( Kumar, S; Prahalathan, P; Raja, B, 2012) |
"Hyperlipidemia is the major risk factors of heart disease such as atherosclerosis, stroke, and death." | 5.35 | Comparison of hypolipidemic activity of synthetic gallic acid-linoleic acid ester with mixture of gallic acid and linoleic acid, gallic acid, and linoleic acid on high-fat diet induced obesity in C57BL/6 Cr Slc mice. ( Jang, A; Jo, C; Lee, JW; Lee, M; Lee, NY; Song, HP; Srinivasan, P, 2008) |
"This study investigated the ameliorative effect of gallic acid (GA) on hypertriglyceridemia and fat accumulation in perirenal adipose tissues of high-fructose diet (HFD)-induced diabetic rats." | 3.88 | Gallic Acid Alleviates Hypertriglyceridemia and Fat Accumulation via Modulating Glycolysis and Lipolysis Pathways in Perirenal Adipose Tissues of Rats Fed a High-Fructose Diet. ( Chang, WC; Huang, DW; Shen, SC; Wu, JS; Yang, HJ, 2018) |
" The present study was intended to appraise the nutraceutical inherent of HPLC standardized Spinacia oleracea methanolic leaf extract (SoLE) in isoproterenol (ISO) induced male albino Wistar rats via activation of pro-inflammatory signaling pathway that drives myocardial necrosis." | 3.85 | Nutraceutical inherent of Spinacia oleracea Linn. methanolic leaf extract ameliorates isoproterenol induced myocardial necrosis in male albino Wistar rats via mitigating inflammation. ( Jolapuram, U; Kodidhela, LD; Vutharadhi, S, 2017) |
"In the relevant literature, there is no experimental study that investigated the axon protective effects of syringic acid- a polyphenol compound- with an anti-oxidant capacity on ischemia/reperfusion injury." | 3.85 | The Axon Protective Effects of Syringic Acid on Ischemia/Reperfusion Injury in a Rat Sciatic Nerve Model. ( Akman, T; Albayrak, SB; Aras, AB; Cosar, M; Gomleksiz, C; Guven, M; Sehitoglu, MH; Tokmak, M; Yaka, U; Yuksel, Y, 2017) |
"Administration of leonurine (60 mg/kg) for 4 weeks significantly alleviated depression-like behaviors of chronic mild stress mice, including increased sucrose preference and reduced immobility time in forced swimming test and tail suspension test." | 3.85 | Leonurine Exerts Antidepressant-Like Effects in the Chronic Mild Stress-Induced Depression Model in Mice by Inhibiting Neuroinflammation. ( Chen, M; Ding, J; Ding, X; Du, R; Hu, G; Jia, M; Li, C; Lu, M; Zheng, Y, 2017) |
"These findings suggest that leonurine ameliorates cognitive dysfunction at least partly via antagonizing excitotoxic glutamate insults and inhibiting autophagy." | 3.83 | Leonurine ameliorates cognitive dysfunction via antagonizing excitotoxic glutamate insults and inhibiting autophagy. ( Gao, J; Liu, C; Xu, X; Yang, Z; Yin, H; Zhang, T, 2016) |
"Combined administration of gigantol and SA synergize to enhance anti-cataract efficacy." | 3.83 | Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract. ( Chen, CY; Chen, D; Fang, H; Gao, X; Li, X; Long, Y; Wei, X; Wu, J; Yi, Y, 2016) |
" Gallic acid (GA) and its derivatives were reported to be effective in treatment of arthritis." | 3.80 | Effect of JEZTC, a synthetic compound, on proliferation and phenotype maintenance of rabbit articular chondrocytes in vitro. ( Lin, X; Liu, L; Liu, Q; Wei, QJ; Zheng, L, 2014) |
"Chronic treatment with trimethylgallic acid esters for 15 days significantly reversed the chronic stress-induced behavioral (impaired locomotor activity, anxiety-like behavior, and decreased percentage of memory retention), biochemical (increased lipid peroxidation and nitrite levels; decreased glutathione levels, superoxide dismutase and catalase activities), and inflammation surge (serum TNF-α) in stressed mice." | 3.80 | Effect of trimethylgallic acid esters against chronic stress-induced anxiety-like behavior and oxidative stress in mice. ( Chadha, R; Dhingra, MS; Dhingra, S; Karan, M; Kumar, A; Kumria, R; Singh, T, 2014) |
" The purpose of the present work was to characterize the interaction and investigate the protective effect of H2 blocker famotidine and gallic acid in combination against experimentally induced peptic ulcer." | 3.80 | Synergistic effect of the combination of gallic acid and famotidine in protection of rat gastric mucosa. ( Asokkumar, K; Sen, S; Sivashanmugam, AT; Subhadradevi, V; Umamaheswari, M, 2014) |
"Leonurine significantly alleviated neurological deficit, decreased brain water content and infarct volume after ischemic stroke, which was accompanied by decreased levels of MDA and Bax, increased activities of SOD, CAT, UCP4, and Bcl-2, and restored ultrastructure of mitochondria." | 3.78 | Leonurine protects brain injury by increased activities of UCP4, SOD, CAT and Bcl-2, decreased levels of MDA and Bax, and ameliorated ultrastructure of mitochondria in experimental stroke. ( Cao, X; Dong, L; Du, Y; Ji, H; Ji, Y; Li, L; Li, S; Liu, H; Wang, C; Xing, Y; Zhang, X; Zhao, K, 2012) |
"The aim of this study was evaluation the effect of Gallic acid on movement disorders and pallidal electrical power in animal model of Parkinson's Disease (PD)." | 3.77 | Motor disorders and impaired electrical power of pallidal EEG improved by gallic acid in animal model of Parkinson's disease. ( Farbood, Y; Mansouri, SM; Sameri, MJ; Sarkaki, A, 2011) |
" This study was designed to evaluate the protective effect of gallic acid on cardiac marker enzymes, troponin-T, LDH-isoenzyme pattern, lipid peroxidation products and antioxidant status in isoproterenol (ISO)-induced myocardial infarction in male Wistar rats." | 3.75 | Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats. ( Prince, PS; Priscilla, DH, 2009) |
"Male Sprague-Dawley rats under permanent middle cerebral artery occlusion (pMCAO) model, randomly assigned as: model, sham, nimodipine (0." | 3.11 | The therapeutic role of Jingchuan tablet on ischaemic cerebral stroke via the HIF-1α/EPO/VEGFA signalling pathway. ( Fu, Y; Li, D; Liu, Q; Wang, H; Wang, W; Zhang, T; Zhang, Y, 2022) |
"The neuropathology of Parkinson's disease (PD) is complex and affects multiple systems of the body beyond the central nervous system." | 1.91 | The effects of gallic acid and vagotomy on motor function, intestinal transit, brain electrophysiology and oxidative stress alterations in a rat model of Parkinson's disease induced by rotenone. ( Bavarsad, K; Farbood, Y; Mard, SA; Sarkaki, A; Sheikhpour, E, 2023) |
"Ethyl gallate was the lead compound and anti-inflammatory active ingredient in Galla chinensis." | 1.72 | Stepwise tracking strategy to screen ingredient from Galla Chinensis based on the "mass spectrometry guided preparative chromatography coupled with systems pharmacology". ( Chen, W; Han, B; Lv, M; Qi, Y; Tian, X; Wang, X; Wang, Z; Xie, Z; Xue, R; Yu, W, 2022) |
"Pretreatment with gallic acid and lithium prevented hyperlocomotion and brain oxidative damage." | 1.62 | Gallic acid protects cerebral cortex, hippocampus, and striatum against oxidative damage and cholinergic dysfunction in an experimental model of manic-like behavior: Comparison with lithium effects. ( Bona, NP; de Mattos, BDS; Gamaro, GD; Pedra, NS; Recart, VM; Soares, MSP; Spanevello, R; Spohr, L; Stefanello, F; Teixeira, FC, 2021) |
"The highest alveolar bone loss was observed in the periodontitis group." | 1.62 | 3,4,5-Trihydroxybenzoic Acid Attenuates Ligature-Induced Periodontal Disease in Wistar Rats. ( Gevrek, F; Karatas, O, 2021) |
"Leonurine treatment significantly inhibited the mortality caused by H1N1 infection." | 1.62 | Leonurine protects against influenza A virus infection-induced pneumonia in mice. ( Chen, XJ; Luo, YJ; Qiu, LN; Tan, YR, 2021) |
"Gallic acid is an active phenolic acid widely distributed in plants, and there is compelling evidence to prove its anti-inflammatory effects." | 1.56 | Gallic Acid Alleviates Gouty Arthritis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling. ( Chen, D; Fu, Z; Huang, X; Li, X; Li, Y; Lin, Y; Liu, A; Luo, T; Pan, H; Weng, A; Yao, Y, 2020) |
"Bisphenol A (BPA) has been reported that among other male reproductive dys-functions, it can cause marked estrogenic effects including alteration in serum hormones as well as testicular lesions in exposed animals." | 1.56 | Chronic exposure of adult male Wistar rats to bisphenol A causes testicular oxidative stress: Role of gallic acid. ( Lanipekun, DO; Oke, BO; Ola-Davies, EO; Olukole, SG, 2020) |
"Gastric ulcers were induced by absolute ethanol (5 mL/kg, i." | 1.56 | Gastroprotective effect of gallic acid against ethanol-induced gastric ulcer in rats: Involvement of the Nrf2/HO-1 signaling and anti-apoptosis role. ( Chang, Y; Duan, LR; Li, H; Li, Y; Tian, T; Wang, SW; Yang, Q; Zhou, D, 2020) |
"Octyl gallate (OG) is a phenolic compound with therapeutic actions namely antimicrobial, antiviral, and antifungal." | 1.56 | Anti-inflammatory effect of octyl gallate in alveolar macrophages cells and mice with acute lung injury. ( Antunes, GL; da Costa, MS; de Oliveira, JR; de Souza Basso, B; Donadio, MVF; Gracia-Sancho, J; Haute, GV; Kaiber, DB; Levorse, VGS; Luft, C; Silveira, JS, 2020) |
"d-galactose (d-gal) can cause damages that resemble accelerated aging in mice." | 1.56 | Gallic acid attenuates thymic involution in the d-galactose induced accelerated aging mice. ( Cao, JH; Chai, YR; Feng, YK; Guo, L; Li, JH; Sun, Y; Wang, LP; Wei, TT, 2020) |
"and gallic acid were evaluated in experimentally induced hyperglycemic animals." | 1.51 | Wound healing activity of Terminalia bellerica Roxb. and gallic acid in experimentally induced diabetic animals. ( Gupta, A; Singh, MP; Sisodia, SS, 2019) |
" This study indicated the potential of phospholipids in promoting the bioavailability of EGCG3''Me and might contribute to the production of functional food with better tea catechins absorption." | 1.51 | The regulation effect of EGCG3''Me phospholipid complex on gut flora of a high-fat diet-induced obesity mouse model. ( Cheng, L; Lin, Y; Yang, H; Zhang, X, 2019) |
"cholerae was studied by performing histology in Swiss albino mice." | 1.51 | In vivo fluid accumulation-inhibitory, anticolonization and anti-inflammatory and in vitro biofilm-inhibitory activities of methyl gallate isolated from Terminalia chebula against fluoroquinolones resistant Vibrio cholerae. ( Acharyya, S; Bag, PK; Bhowmik, P; Koley, H; Roy, N; Saha, DR; Sarkar, P, 2019) |
"Neurodegenerative diseases comprise demyelination and synaptic loss." | 1.51 | Gallic and vanillic acid suppress inflammation and promote myelination in an in vitro mouse model of neurodegeneration. ( Jamali, KS; Kamal, A; Khan, F; Saify, ZS; Siddiqui, S, 2019) |
"However, the effects of GA on ulcerative colitis (UC) remain unknown." | 1.51 | Gallic acid improved inflammation via NF-κB pathway in TNBS-induced ulcerative colitis. ( Gu, P; Shen, H; Zhu, L, 2019) |
"Endometritis is the inflammation of the endometrium that is associated with lower conception rates, increased intervals from calving to first service, and more culls for failure to conceive, which leads to serious economic losses in the dairy industry." | 1.48 | Leonurine ameliorates the inflammatory responses in lipopolysaccharide-induced endometritis. ( Chen, X; Dai, A; Deng, G; Huang, C; Jiang, K; Li, X; Wu, H; Yang, X, 2018) |
"Leonurine is a compound derived from Herba leonuri, which has been reported to protect cardiac tissue against ischemic injury via antioxidant and anti‑apoptosis effects." | 1.48 | Leonurine protects cardiac function following acute myocardial infarction through anti‑apoptosis by the PI3K/AKT/GSK3β signaling pathway. ( Jiang, X; Wei, F; Xu, L; Zhu, H, 2018) |
"Gallic acid was evaluated for its possible effect at the dose of 20 and 40 mg/kg body weight." | 1.48 | Gallic acid attenuates type I diabetic nephropathy in rats. ( Garud, MS; Kulkarni, YA, 2018) |
"Gallic acid has been reported to possess a number of psychopharmacological activities." | 1.48 | Protective effect of gallic acid in experimental model of ketamine-induced psychosis: possible behaviour, biochemical, neurochemical and cellular alterations. ( Dhingra, MS; Dhingra, S; Jindal, DK; Kumar, A; Parle, M; Yadav, M, 2018) |
" The QUIN is involved in the development of several toxic cascades which leads to the neuronal degeneration processes." | 1.48 | Effect of wedelolactone and gallic acid on quinolinic acid-induced neurotoxicity and impaired motor function: significance to sporadic amyotrophic lateral sclerosis. ( Goli, D; S, M; T, P, 2018) |
"Syringic acid (SA) is a phenolic compound present in the fruit of the açaí palm Euterpe oleracea and the mycelium of the shiitake mushroom Lentinula edodes." | 1.46 | Antiosteoporotic activity of a syringic acid diet in ovariectomized mice. ( Fukuta, Y; Kawaguchi, N; Moriyama, T; Shirasaka, N; Tanaka, T; Zaima, N, 2017) |
"To date, there is no effective Alzheimer's disease (AD)-modifying therapy." | 1.46 | Combination therapy with octyl gallate and ferulic acid improves cognition and neurodegeneration in a transgenic mouse model of Alzheimer's disease. ( Koyama, N; Maeda, M; Mori, T; Segawa, T; Tan, J; Town, T, 2017) |
"Cardiac hypertrophy was induced by isoproterenol (ISP) in mice and primary neonatal cardiomyocytes." | 1.43 | Gallic acid prevents isoproterenol-induced cardiac hypertrophy and fibrosis through regulation of JNK2 signaling and Smad3 binding activity. ( Cho, JY; Choi, SY; Jeong, MH; Jin, L; Kee, HJ; Kim, GR; Lin, MQ; Piao, ZH; Ryu, Y, 2016) |
"Fibrosis is one of the characteristic features of chronic kidney disease (CKD)." | 1.42 | Leonurine ameliorates kidney fibrosis via suppressing TGF-β and NF-κB signaling pathway in UUO mice. ( Bo, Y; Cheng, H; Jia, Z; Li, F; Shen, W; Tan, J; Xu, C, 2015) |
"Gallic acid (GA) is a polyhydroxy phenolic compound that has been detected in various natural products, such as green tea, strawberries, grapes, bananas, and many other fruits." | 1.42 | Gallic acid attenuates dextran sulfate sodium-induced experimental colitis in BALB/c mice. ( Looi, CY; Mohebali, N; Norhaizan, ME; Pandurangan, AK, 2015) |
"Gallic acid was given 15 mins before ischemia induction." | 1.40 | The examination of protective effects of gallic acid against damage of oxidative stress during induced-experimental renal ischemia-reperfusion in experiment. ( Bayramoglu, G; Canbek, M; Ceyhan, E; Durmus, B; Kanbak, G; Kartkaya, K; Ozen, A; Oztopcu Vatan, AP; Senturk, H; Uyanoglu, M, 2014) |
" Furthermore, chronic administration of GA significantly restored the spatial memory, total thiol and GPx contents and also decreased MDA levels in these tissues." | 1.40 | Protective effects of gallic acid against chronic cerebral hypoperfusion-induced cognitive deficit and brain oxidative damage in rats. ( Farbood, Y; Fathi Moghaddam, H; Korani, MS; Sarkaki, A; Taghi Mansouri, M, 2014) |
"Gallic acid is a natural polyphenolic acid found in gall nuts, sumac, oak bark, tea leaves, grapes and wine, with potent antioxidant and antiapoptotic activity." | 1.39 | Gallic acid decreases vacuous chewing movements induced by reserpine in rats. ( Bürger, ME; de Freitas, CM; Fachinetto, R; Ferrari, MC; Peroza, LR; Reckziegel, P; Schaffer, LF, 2013) |
"Vasopressor therapy is required in septic shock to maintain tissue perfusion in the face of hypotension." | 1.38 | Benefits of ethyl gallate versus norepinephrine in the treatment of cardiovascular collapse in Pseudomonas aeruginosa septic shock in dogs. ( Cheng, ZQ; Gotes, J; Jacobs, H; Kasian, K; Mink, SN, 2012) |
"Hypertension was induced in adult male albino rats by oral administration of L-NAME (40 mg/kg/day) dissolved in drinking water daily for 4 weeks." | 1.38 | Syringic acid ameliorates (L)-NAME-induced hypertension by reducing oxidative stress. ( Kumar, S; Prahalathan, P; Raja, B, 2012) |
"Gallic acid content was 0." | 1.36 | Antiinflammatory and antioxidant activities of gum mastic. ( Ebrahimzadeh, MA; Eslami, Sh; Hafezi, S; Mahmoudi, M; Nabavi, SF; Nabavi, SM, 2010) |
"Hyperlipidemia is the major risk factors of heart disease such as atherosclerosis, stroke, and death." | 1.35 | Comparison of hypolipidemic activity of synthetic gallic acid-linoleic acid ester with mixture of gallic acid and linoleic acid, gallic acid, and linoleic acid on high-fat diet induced obesity in C57BL/6 Cr Slc mice. ( Jang, A; Jo, C; Lee, JW; Lee, M; Lee, NY; Song, HP; Srinivasan, P, 2008) |
"Pretreatment with gallic acid (15 mg/kg) to isoproterenol treated rats significantly (P<0." | 1.35 | Gallic acid prevents lysosomal damage in isoproterenol induced cardiotoxicity in Wistar rats. ( Devika, PT; Priscilla, H; Stanely Mainzen Prince, P, 2009) |
"Luteolin was found histologically to suppress inflammation in lung tissue, the development of C." | 1.33 | In vivo treatment of acute Chlamydia pneumoniae infection with the flavonoids quercetin and luteolin and an alkyl gallate, octyl gallate, in a mouse model. ( Leinonen, M; Saario, E; Saikku, P; Törmäkangas, L; Vuorela, H; Vuorela, P, 2005) |
"ETEC-induced diarrhea is initiated by the binding of B subunit of heat-labile enterotoxin (LTB) to the ganglioside G(M1) on the surface of intestinal epithelial cell." | 1.33 | Anti-diarrheal effect of Galla Chinensis on the Escherichia coli heat-labile enterotoxin and ganglioside interaction. ( Chang, YS; Chen, JC; Ho, TY; Hsiang, CY; Wu, SL, 2006) |
" The 500 mg/kg GSH ester reduced hearing loss and OHC loss, but protection decreased as dosage increased, suggesting possible toxicity." | 1.32 | Glutathione ester but not glutathione protects against cisplatin-induced ototoxicity in a rat model. ( Campbell, KC; Hughes, LF; Larsen, DL; Meech, RP; Rybak, LP, 2003) |
"Acute myocardial ischemia was induced in anesthetized cats by a 60-min occlusion of the left anterior descending coronary artery (LAD)." | 1.31 | Differential acetylcholine release mechanisms in the ischemic and non-ischemic myocardium. ( Akiyama, T; Inagaki, M; Kawada, T; Sato, T; Shishido, T; Sugimachi, M; Sunagawa, K; Takaki, H; Yamazaki, T, 2000) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (0.84) | 18.7374 |
1990's | 1 (0.84) | 18.2507 |
2000's | 14 (11.76) | 29.6817 |
2010's | 79 (66.39) | 24.3611 |
2020's | 24 (20.17) | 2.80 |
Authors | Studies |
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Abrams, RPM | 1 |
Yasgar, A | 1 |
Teramoto, T | 1 |
Lee, MH | 1 |
Dorjsuren, D | 1 |
Eastman, RT | 1 |
Malik, N | 1 |
Zakharov, AV | 1 |
Li, W | 1 |
Bachani, M | 1 |
Brimacombe, K | 1 |
Steiner, JP | 1 |
Hall, MD | 1 |
Balasubramanian, A | 1 |
Jadhav, A | 1 |
Padmanabhan, R | 1 |
Simeonov, A | 1 |
Nath, A | 1 |
Qiu, LN | 1 |
Tan, YR | 1 |
Luo, YJ | 1 |
Chen, XJ | 1 |
Wang, Z | 1 |
Xue, R | 1 |
Lv, M | 1 |
Qi, Y | 1 |
Yu, W | 1 |
Xie, Z | 2 |
Chen, W | 1 |
Wang, X | 3 |
Tian, X | 2 |
Han, B | 2 |
Qi, L | 1 |
Chen, X | 3 |
Pan, Y | 1 |
Zha, Z | 1 |
Tang, M | 1 |
Shi, C | 1 |
Yang, B | 1 |
Wang, H | 2 |
Zhou, D | 2 |
Wu, Y | 1 |
Yan, H | 1 |
Shen, T | 1 |
Li, S | 2 |
Gong, J | 1 |
Li, G | 2 |
Mai, H | 1 |
Wang, D | 1 |
Tan, X | 1 |
Zhang, Y | 4 |
Liu, Q | 3 |
Zhang, T | 2 |
Fu, Y | 1 |
Wang, W | 1 |
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Jin, L | 2 |
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Choi, SY | 2 |
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Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Effect of Consumption of a Beverage of Chaya (Cnidoscolus Chayamansa) on Lipid Concentration, Lipid Peroxidation and Antioxidant Status of Patients With Dyslipidemia[NCT04110392] | 30 participants (Actual) | Interventional | 2019-06-01 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
2 reviews available for gallic acid and Disease Models, Animal
Article | Year |
---|---|
Therapeutic approaches employing natural compounds and derivatives for treating bipolar disorder: emphasis on experimental models of the manic phase.
Topics: Animals; Biological Products; Bipolar Disorder; Disease Models, Animal; Fatty Acids, Omega-3; Gallic | 2021 |
Suppression of biofilm related, device-associated infections by staphylococcal quorum sensing inhibitors.
Topics: Animals; Anti-Infective Agents; Biofilms; Catheter-Related Infections; Catheters, Indwelling; Diseas | 2008 |
1 trial available for gallic acid and Disease Models, Animal
Article | Year |
---|---|
The therapeutic role of Jingchuan tablet on ischaemic cerebral stroke via the HIF-1α/EPO/VEGFA signalling pathway.
Topics: Animals; Brain Ischemia; Chlorogenic Acid; Disease Models, Animal; Gallic Acid; Infarction, Middle C | 2022 |
116 other studies available for gallic acid and Disease Models, Animal
Article | Year |
---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Leonurine protects against influenza A virus infection-induced pneumonia in mice.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Gallic Acid; Gene Expression R | 2021 |
Stepwise tracking strategy to screen ingredient from Galla Chinensis based on the "mass spectrometry guided preparative chromatography coupled with systems pharmacology".
Topics: Animals; Animals, Outbred Strains; Anti-Inflammatory Agents; Caco-2 Cells; Chromatography, High Pres | 2022 |
Leonurine exerts a protective effect in dextran sodium sulfate-induced experimental inflammatory bowel disease mice model.
Topics: Animals; Anti-Inflammatory Agents; Dextran Sulfate; Disease Models, Animal; Gallic Acid; Inflammator | 2022 |
Gallic acid ameliorates calcium oxalate crystal-induced renal injury via upregulation of Nrf2/HO-1 in the mouse model of stone formation.
Topics: Animals; Antioxidants; Calcium Oxalate; Disease Models, Animal; Gallic Acid; Glyoxylates; Kidney; Mi | 2022 |
Gallic Acid Ameliorates Aspergillus Fumigatus Keratitis Through Reducing Fungal Load and Suppressing the Inflammatory Response.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Cytokines; Disease Models, Animal; | 2022 |
The effects of gallic acid and vagotomy on motor function, intestinal transit, brain electrophysiology and oxidative stress alterations in a rat model of Parkinson's disease induced by rotenone.
Topics: Animals; Brain; Disease Models, Animal; Electrophysiology; Gallic Acid; Male; Neuroprotective Agents | 2023 |
Gallic acid regulates immune response in a mouse model of rheumatoid arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cytokines; Disease Models, Animal; Gallic A | 2023 |
Wound healing activity of Terminalia bellerica Roxb. and gallic acid in experimentally induced diabetic animals.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Fruit; Gallic Acid; India; Plant E | 2019 |
Does cartilage ERα overexpression correlate with osteoarthritic chondrosenescence? Indications from
Topics: Aging; Animals; Bone Development; Cartilage; Chondrocytes; Diclofenac; Disease Models, Animal; Estro | 2019 |
Gallic acid attenuates thymic involution in the d-galactose induced accelerated aging mice.
Topics: Aging, Premature; Animals; CD4-Positive T-Lymphocytes; Cell Count; Cell Proliferation; Cells, Cultur | 2020 |
Gallic acid regulates adipocyte hypertrophy and suppresses inflammatory gene expression induced by the paracrine interaction between adipocytes and macrophages in vitro and in vivo.
Topics: Adipocytes; Animals; Disease Models, Animal; Gallic Acid; Gene Expression; Hypertrophy; Inflammation | 2020 |
Anti-inflammatory effect of octyl gallate in alveolar macrophages cells and mice with acute lung injury.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Gallic Acid; Humans; Inflammation; Lung; Lung In | 2020 |
3,4,5-Trihydroxybenzoic Acid Attenuates Ligature-Induced Periodontal Disease in Wistar Rats.
Topics: Alveolar Bone Loss; Animals; Collagenases; Disease Models, Animal; Gallic Acid; Osteoblasts; Osteocl | 2021 |
Gastroprotective effect of gallic acid against ethanol-induced gastric ulcer in rats: Involvement of the Nrf2/HO-1 signaling and anti-apoptosis role.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Apoptosis; Biopsy; Cytokines; Dinoprostone; Disease Models | 2020 |
Chronic exposure of adult male Wistar rats to bisphenol A causes testicular oxidative stress: Role of gallic acid.
Topics: Animals; Antioxidants; Benzhydryl Compounds; Disease Models, Animal; Endocrine Disruptors; Gallic Ac | 2020 |
Gallic acid is a dual α/β-secretase modulator that reverses cognitive impairment and remediates pathology in Alzheimer mice.
Topics: ADAM10 Protein; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secreta | 2020 |
Tissue distribution and molecular docking research on the active components of Bidens bipinnata L. against hyperlipidemia.
Topics: Animals; Bidens; Catechin; Chromatography, High Pressure Liquid; Disease Models, Animal; Drugs, Chin | 2021 |
Leonurine Attenuates Myocardial Fibrosis Through Upregulation of miR-29a-3p in Mice Post-myocardial Infarction.
Topics: Angiotensin II; Animals; Cell Movement; Cell Proliferation; Cells, Cultured; Collagen; Disease Model | 2021 |
Gallic Acid Alleviates Gouty Arthritis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Cells, Cultured; Disease Models, Animal; Gallic | 2020 |
Gallic acid protects cerebral cortex, hippocampus, and striatum against oxidative damage and cholinergic dysfunction in an experimental model of manic-like behavior: Comparison with lithium effects.
Topics: Animals; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Gallic Acid; Hippocampus; Lithium | 2021 |
The benzoate plant metabolite ethyl gallate prevents cellular- and vascular-lipid accumulation in experimental models of atherosclerosis.
Topics: Animals; Apolipoproteins E; Atherosclerosis; ATP-Binding Cassette Transporters; Benzoates; Cholester | 2021 |
Ferroptosis-related Genes for Overall Survival Prediction in Patients with Colorectal Cancer can be Inhibited by Gallic acid.
Topics: Animals; Case-Control Studies; Colitis, Ulcerative; Colorectal Neoplasms; Disease Models, Animal; Dr | 2021 |
Gallic acid anti-myotoxic activity and mechanism of action, a snake venom phospholipase A
Topics: Anacardium; Animals; Disease Models, Animal; Gallic Acid; Gene Expression Regulation, Enzymologic; M | 2021 |
Grape seed proanthocyanidin supplementation reduces adipocyte size and increases adipocyte number in obese rats.
Topics: Adipocytes; Adiposity; Animals; Antioxidants; Disease Models, Animal; Fatty Acid-Binding Proteins; G | 2017 |
Combination therapy with octyl gallate and ferulic acid improves cognition and neurodegeneration in a transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Co | 2017 |
The in vitro and in vivo protective effects of tannin derivatives against Salmonella enterica serovar Typhimurium infection.
Topics: Adhesins, Bacterial; Animals; Anti-Bacterial Agents; Bacterial Load; Cell Survival; Chemokine CCL2; | 2017 |
Protective effect of gallic acid in experimental model of ketamine-induced psychosis: possible behaviour, biochemical, neurochemical and cellular alterations.
Topics: Animals; Antioxidants; Behavior, Animal; Brain; Disease Models, Animal; Female; Gallic Acid; gamma-A | 2018 |
Antiosteoporotic activity of a syringic acid diet in ovariectomized mice.
Topics: Animals; Bone and Bones; Bone Density; Bone Resorption; Diet; Disease Models, Animal; Euterpe; Femal | 2017 |
Ameliorative Effect of Gallic Acid in Doxorubicin-Induced Hepatotoxicity in Wistar Rats Through Antioxidant Defense System.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Bilirubin; Catalase; Chemical and | 2018 |
Chemical composition and diuretic, natriuretic and kaliuretic effects of extracts of Mimosa bimucronata (DC.) Kuntze leaves and its majority constituent methyl gallate in rats.
Topics: Administration, Oral; Animals; Atropine; Cell Line; Disease Models, Animal; Diuretics; Gallic Acid; | 2017 |
Antidepressant-like effect of gallic acid in mice: Dual involvement of serotonergic and catecholaminergic systems.
Topics: Animals; Antidepressive Agents; Catecholamines; Depression; Disease Models, Animal; Dose-Response Re | 2017 |
Leonurine Exerts Antidepressant-Like Effects in the Chronic Mild Stress-Induced Depression Model in Mice by Inhibiting Neuroinflammation.
Topics: Animals; Antidepressive Agents; Calcium-Binding Proteins; Cytokines; Depression; Disease Models, Ani | 2017 |
Protective effects of gallic acid against methotrexate-induced toxicity in rats.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Aspartate Aminotransferases; Biomarkers; Biopsy | 2018 |
Gallic acid attenuates pulmonary fibrosis in a mouse model of transverse aortic contraction-induced heart failure.
Topics: Animals; Aorta; Cadherins; Connective Tissue Growth Factor; Constriction; Disease Models, Animal; Ep | 2017 |
Ulcer Prevention Effect Of 3,4,5-Tihydroxy-N0-[(2-Methyl-1H-Indol-3yl)Methylidene]Benzohydrazide In HCl/Ethanol-Induced Gastric Mucosal Damage In Rats.
Topics: Animals; Antioxidants; bcl-2-Associated X Protein; Disease Models, Animal; Ethanol; Gallic Acid; Gas | 2017 |
Gallic acid attenuates type I diabetic nephropathy in rats.
Topics: Animals; Antioxidants; Blood Urea Nitrogen; Creatinine; Diabetes Mellitus, Experimental; Diabetes Me | 2018 |
Gallic Acid Alleviates Hypertriglyceridemia and Fat Accumulation via Modulating Glycolysis and Lipolysis Pathways in Perirenal Adipose Tissues of Rats Fed a High-Fructose Diet.
Topics: Adipose Tissue; Adiposity; Animals; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Diet, | 2018 |
Phytochemical analysis and antibacterial activity of methanolic extract of Bergenia purpurascens against common respiratory infection causing bacterial species in vitro and in neonatal rats.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antioxidants; Bacteria; Benzopyrans; Catec | 2018 |
Upregulating mTOR/ERK signaling with leonurine for promoting angiogenesis and tissue regeneration in a full-thickness cutaneous wound model.
Topics: Angiogenesis Inducing Agents; Animals; Cell Movement; Disease Models, Animal; Drugs, Chinese Herbal; | 2018 |
Metagenomics Analysis of Gut Microbiota in a High Fat Diet-Induced Obesity Mouse Model Fed with (-)-Epigallocatechin 3-O-(3-O-Methyl) Gallate (EGCG3″Me).
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Gallic Acid; Gastrointestinal Microbiome; Male; Met | 2018 |
Leonurine protects cardiac function following acute myocardial infarction through anti‑apoptosis by the PI3K/AKT/GSK3β signaling pathway.
Topics: Administration, Oral; Animals; Apoptosis; bcl-2-Associated X Protein; Cardiotonic Agents; Cerebrovas | 2018 |
Leonurine ameliorates the inflammatory responses in lipopolysaccharide-induced endometritis.
Topics: Animals; Anti-Inflammatory Agents; Cattle; Cells, Cultured; Disease Models, Animal; Endometritis; En | 2018 |
Potential of the association of dodecyl gallate with nanostructured lipid system as a treatment for paracoccidioidomycosis: In vitro and in vivo efficacy and toxicity.
Topics: Animals; Antifungal Agents; Biological Availability; Cell Line; Disease Models, Animal; Female; Fibr | 2018 |
The antioxidant gallic acid induces anxiolytic-, but not antidepressant-like effect, in streptozotocin-induced diabetes.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Antioxidants; Anxiety; Behavior, Animal; Depres | 2018 |
Effect of wedelolactone and gallic acid on quinolinic acid-induced neurotoxicity and impaired motor function: significance to sporadic amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antioxidants; Apoptosis; Brain; Coumarins; Disease Models, A | 2018 |
A Novel Synthesized Sulfonamido-Based Gallate-JEZTC Blocks Cartilage Degradation on Rabbit Model of Osteoarthritis: An in Vitro and in Vivo Study.
Topics: Animals; Apoptosis; Benzamides; Cartilage, Articular; Chondrocytes; Disease Models, Animal; Down-Reg | 2018 |
Leonurine inhibits IL-1β induced inflammation in murine chondrocytes and ameliorates murine osteoarthritis.
Topics: Animals; Chondrocytes; Disease Models, Animal; Gallic Acid; Gene Expression Regulation; Interleukin- | 2018 |
Gallic acid activates hippocampal BDNF-Akt-mTOR signaling in chronic mild stress.
Topics: Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Gallic Acid; Hippocampus; Mice; | 2019 |
Leonurine ameliorates adriamycin-induced podocyte injury via suppression of oxidative stress.
Topics: Animals; Apoptosis; Disease Models, Animal; Doxorubicin; Gallic Acid; Humans; Kidney; Kidney Disease | 2018 |
Effect of Syringic acid on antioxidant biomarkers and associated inflammatory markers in mice model of asthma.
Topics: Animals; Anti-Asthmatic Agents; Antioxidants; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disea | 2019 |
Gallic acid improved inflammation via NF-κB pathway in TNBS-induced ulcerative colitis.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cell Line; Cell Proliferation; Colitis, Ulcerative; Cy | 2019 |
Leonurine suppresses neuroinflammation through promoting oligodendrocyte maturation.
Topics: Animals; Cell Differentiation; Central Nervous System; Cuprizone; Disease Models, Animal; Encephalom | 2019 |
Gallic and vanillic acid suppress inflammation and promote myelination in an in vitro mouse model of neurodegeneration.
Topics: Action Potentials; Animals; Demyelinating Diseases; Disease Models, Animal; Extracellular Matrix Pro | 2019 |
In vivo fluid accumulation-inhibitory, anticolonization and anti-inflammatory and in vitro biofilm-inhibitory activities of methyl gallate isolated from Terminalia chebula against fluoroquinolones resistant Vibrio cholerae.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Biofilms; Cell Membrane; Cholera; Disease | 2019 |
Protective effects of ethyl gallate and pentagalloylglucose, the active components of Qingwen Baidu Decoction, against lipopolysaccharide-induced acute lung injury in rats.
Topics: Acute Lung Injury; Animals; Capillary Permeability; Disease Models, Animal; Drugs, Chinese Herbal; G | 2019 |
Gallic acid alleviates nasal inflammation via activation of Th1 and inhibition of Th2 and Th17 in a mouse model of allergic rhinitis.
Topics: Allergens; Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Eosinophils; Gallic | 2019 |
A holistic view of gallic acid-induced attenuation in colitis based on microbiome-metabolomics analysis.
Topics: Amino Acids; Animals; Bacteria; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Fatty | 2019 |
The regulation effect of EGCG3''Me phospholipid complex on gut flora of a high-fat diet-induced obesity mouse model.
Topics: Animals; Bacteria; Camellia sinensis; Diet, High-Fat; Disease Models, Animal; Gallic Acid; Gastroint | 2019 |
3,4,5-trihydroxycinnamic acid inhibits lipopolysaccharide (LPS)-induced inflammation by Nrf2 activation in vitro and improves survival of mice in LPS-induced endotoxemia model in vivo.
Topics: Animals; Cell Line; Disease Models, Animal; Endotoxemia; Gallic Acid; Gene Expression Regulation; Hu | 2014 |
Protective effects of gallic acid against chronic cerebral hypoperfusion-induced cognitive deficit and brain oxidative damage in rats.
Topics: Animals; Antioxidants; Brain; Brain Ischemia; Chronic Disease; Cognition Disorders; Disease Models, | 2014 |
Metabolomic signatures in peripheral blood associated with Alzheimer's disease amyloid-β-induced neuroinflammation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Biomarkers; Disease Models, Animal; Encephalitis; | 2014 |
Synergistic effect of the combination of gallic acid and famotidine in protection of rat gastric mucosa.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Disease Models, Animal; Drug Synergism; Drug Therapy, Comb | 2014 |
Effect of trimethylgallic acid esters against chronic stress-induced anxiety-like behavior and oxidative stress in mice.
Topics: Animals; Antioxidants; Anxiety; Behavior, Animal; Chronic Disease; Disease Models, Animal; Esters; G | 2014 |
Effect of JEZTC, a synthetic compound, on proliferation and phenotype maintenance of rabbit articular chondrocytes in vitro.
Topics: Animals; Antioxidants; Arthritis; Benzamides; Cartilage, Articular; Cell Proliferation; Chondrocytes | 2014 |
The examination of protective effects of gallic acid against damage of oxidative stress during induced-experimental renal ischemia-reperfusion in experiment.
Topics: Animals; Disease Models, Animal; Gallic Acid; Kidney Diseases; Male; Oxidative Stress; Rats, Sprague | 2014 |
Leonurine hydrochloride inhibits osteoclastogenesis and prevents osteoporosis associated with estrogen deficiency by inhibiting the NF-κB and PI3K/Akt signaling pathways.
Topics: Animals; Blotting, Western; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Electroph | 2015 |
Leonurine ameliorates kidney fibrosis via suppressing TGF-β and NF-κB signaling pathway in UUO mice.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Epithelial-Mesenchymal Transit | 2015 |
Gallic acid can play a chondroprotective role against AGE-induced osteoarthritis progression.
Topics: Animals; Cartilage, Articular; Cells, Cultured; Chondrocytes; Disease Models, Animal; Disease Progre | 2015 |
Gallic acid improved behavior, brain electrophysiology, and inflammation in a rat model of traumatic brain injury.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Behavior, Animal; Brain; Brain Injuries; Cy | 2015 |
Protective Effects of Catechin against Monosodium Urate-Induced Inflammation through the Modulation of NLRP3 Inflammasome Activation.
Topics: Animals; Calcium; Carrier Proteins; Catechin; Disease Models, Animal; Free Radical Scavengers; Galli | 2015 |
Gallic acid attenuates dextran sulfate sodium-induced experimental colitis in BALB/c mice.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Colitis; Colon; Cytoprotection; Dextran Sulfate; Di | 2015 |
Gallic acid suppresses inflammation in dextran sodium sulfate-induced colitis in mice: Possible mechanisms.
Topics: Animals; Colitis; Cyclooxygenase 2; Cytokines; Dextran Sulfate; Disease Models, Animal; Gallic Acid; | 2015 |
Gallic acid ameliorates renal functions by inhibiting the activation of p38 MAPK in experimentally induced type 2 diabetic rats and cultured rat proximal tubular epithelial cells.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephr | 2015 |
Gallic acid-based indanone derivative interacts synergistically with tetracycline by inhibiting efflux pump in multidrug resistant E. coli.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Disease Models, Animal; Drug Synergism; Drug-R | 2016 |
Identification of gallic acid based glycoconjugates as a novel tubulin polymerization inhibitors.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Proliferation; Disease Models, Animal; D | 2016 |
Hepatoprotective effect of trimethylgallic acid esters against carbon tetrachloride-induced liver injury in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemical and Drug | 2015 |
Mechanism(s) of action underlying the gastroprotective effect of ethyl acetate fraction obtained from the crude methanolic leaves extract of Muntingia calabura.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Dinoprostone; Disease Models, Animal; Gallic Acid; Gastric | 2016 |
Anti-Inflammatory Activities of Pentaherbs Formula, Berberine, Gallic Acid and Chlorogenic Acid in Atopic Dermatitis-Like Skin Inflammation.
Topics: Animals; Anti-Inflammatory Agents; Berberine; Cells, Cultured; Chemokines; Chlorogenic Acid; Cocultu | 2016 |
Galla chinensis Compounds Remineralize Enamel Caries Lesions in a Rat Model.
Topics: Animals; Dental Caries; Dental Enamel; Diet, Cariogenic; Disease Models, Animal; Drugs, Chinese Herb | 2016 |
Antiviral Effects of Black Raspberry (Rubus coreanus) Seed and Its Gallic Acid against Influenza Virus Infection.
Topics: Animals; Antiviral Agents; Chromatography, Liquid; Disease Models, Animal; Gallic Acid; Influenza A | 2016 |
Anti-ulcer mechanisms of polyphenols extract of Euphorbia umbellata (Pax) Bruyns (Euphorbiaceae).
Topics: Animals; Anti-Bacterial Agents; Anti-Ulcer Agents; Antioxidants; Benzothiazoles; Chromatography, Hig | 2016 |
Protective effect of Gallic acid on doxorubicin-induced testicular and epididymal toxicity.
Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Apoptosis; Caspase 3; Disease Models, Animal; Do | 2017 |
Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract.
Topics: Aldehyde Reductase; Animals; Bibenzyls; Cataract; Cell Line; Cell Survival; Diabetes Complications; | 2016 |
The Axon Protective Effects of Syringic Acid on Ischemia/Reperfusion Injury in a Rat Sciatic Nerve Model.
Topics: Animals; Apoptosis; Axons; Disease Models, Animal; Gallic Acid; Male; Neuroprotective Agents; Oxidat | 2017 |
Gallic acid prevents isoproterenol-induced cardiac hypertrophy and fibrosis through regulation of JNK2 signaling and Smad3 binding activity.
Topics: Animals; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Fibrosis; Gallic Acid; Gene Expressi | 2016 |
Leonurine ameliorates cognitive dysfunction via antagonizing excitotoxic glutamate insults and inhibiting autophagy.
Topics: Animals; Autophagy; Brain; Cognitive Dysfunction; Disease Models, Animal; Excitatory Postsynaptic Po | 2016 |
Nutraceutical inherent of Spinacia oleracea Linn. methanolic leaf extract ameliorates isoproterenol induced myocardial necrosis in male albino Wistar rats via mitigating inflammation.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cardiomyopathies; Chromatography, High Pressure Liquid | 2017 |
Methyl Gallate Inhibits Osteoclast Formation and Function by Suppressing Akt and Btk-PLCγ2-Ca
Topics: Actins; Agammaglobulinaemia Tyrosine Kinase; Animals; Biomarkers; Bone Resorption; Calcium; Disease | 2017 |
The modulatory effect of (-)-epigallocatechin 3-O-(3-O-methyl) gallate (EGCG3″Me) on intestinal microbiota of high fat diet-induced obesity mice model.
Topics: Adult; Animals; Bacteroidetes; Diet, High-Fat; Disease Models, Animal; DNA, Bacterial; Feces; Female | 2017 |
Comparison of hypolipidemic activity of synthetic gallic acid-linoleic acid ester with mixture of gallic acid and linoleic acid, gallic acid, and linoleic acid on high-fat diet induced obesity in C57BL/6 Cr Slc mice.
Topics: Adipocytes; Adipose Tissue; Animals; Body Weight; Cell Nucleus; Cholesterol, HDL; Cholesterol, LDL; | 2008 |
Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Biomarkers; Cardiotonic Ag | 2009 |
Gallic acid prevents lysosomal damage in isoproterenol induced cardiotoxicity in Wistar rats.
Topics: Acetylglucosaminidase; Adrenergic beta-Agonists; Animals; Antioxidants; beta-Galactosidase; Biomarke | 2009 |
Antioxidant, antimutagenic, and antidiabetic activities of edible leaves from Cnidoscolus chayamansa Mc. Vaugh.
Topics: Animals; Antimutagenic Agents; Antioxidants; Catechin; Chromatography, High Pressure Liquid; Diabete | 2010 |
Antiinflammatory and antioxidant activities of gum mastic.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biphenyl Compounds; Carrageenan; Chromatography, Hi | 2010 |
Neuroprotective effects of leonurine on ischemia/reperfusion-induced mitochondrial dysfunctions in rat cerebral cortex.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Brain Ischemia; Cer | 2010 |
Locomotor damage and brain oxidative stress induced by lead exposure are attenuated by gallic acid treatment.
Topics: Animals; Antioxidants; Behavior, Animal; Brain; Catalase; Chelating Agents; Disease Models, Animal; | 2011 |
Benefits of ethyl gallate versus norepinephrine in the treatment of cardiovascular collapse in Pseudomonas aeruginosa septic shock in dogs.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug | 2012 |
Anti-inflammatory activity of Pistacia khinjuk in different experimental models: isolation and characterization of its flavonoids and galloylated sugars.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Disease Models, Animal; Drug Discove | 2012 |
Ferulic acid is nephrodamaging while gallic acid is renal protective in long term treatment of chronic kidney disease.
Topics: Animals; Antioxidants; Collagen; Coumaric Acids; Dietary Supplements; Disease Models, Animal; Fibros | 2012 |
Motor disorders and impaired electrical power of pallidal EEG improved by gallic acid in animal model of Parkinson's disease.
Topics: Adrenergic Agents; Animals; Antioxidants; Disease Models, Animal; Electroencephalography; Gallic Aci | 2011 |
Leonurine protects brain injury by increased activities of UCP4, SOD, CAT and Bcl-2, decreased levels of MDA and Bax, and ameliorated ultrastructure of mitochondria in experimental stroke.
Topics: Animals; bcl-2-Associated X Protein; Blotting, Western; Brain Injuries; Catalase; Disease Models, An | 2012 |
Syringic acid ameliorates (L)-NAME-induced hypertension by reducing oxidative stress.
Topics: Animals; Antioxidants; Biomarkers; Blood Pressure; Disease Models, Animal; Dose-Response Relationshi | 2012 |
Gallic acid decreases vacuous chewing movements induced by reserpine in rats.
Topics: Adrenergic Uptake Inhibitors; Animals; Antioxidants; Antipsychotic Agents; Brain; Disease Models, An | 2013 |
Glutathione ester but not glutathione protects against cisplatin-induced ototoxicity in a rat model.
Topics: Acoustic Stimulation; Animals; Antineoplastic Agents; Cisplatin; Disease Models, Animal; Evoked Pote | 2003 |
Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the rat.
Topics: Aminoquinolines; Animals; Anti-HIV Agents; Antineoplastic Agents; Behavior, Animal; Calcium Channel | 2004 |
In vivo treatment of acute Chlamydia pneumoniae infection with the flavonoids quercetin and luteolin and an alkyl gallate, octyl gallate, in a mouse model.
Topics: Animals; Base Sequence; Chlamydia Infections; Chlamydophila pneumoniae; Disease Models, Animal; DNA | 2005 |
Anti-diarrheal effect of Galla Chinensis on the Escherichia coli heat-labile enterotoxin and ganglioside interaction.
Topics: Animals; Antidiarrheals; Bacterial Toxins; Binding, Competitive; Diarrhea; Disease Models, Animal; D | 2006 |
Blockade of intracellular calcium release induces an antidepressant-like effect in the mouse forced swimming test.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Calcium; Calcium Channel Blo | 2006 |
The anti-anaphylactic effect of the gall of Rhus javanica is mediated through inhibition of histamine release and inflammatory cytokine secretion.
Topics: Anaphylaxis; Animals; Anti-Allergic Agents; Calcium; Cell Line; Cyclic AMP; Cytokines; Disease Model | 2005 |
Gastroprotective effect of standardized extract of Ficus glomerata fruit on experimental gastric ulcers in rats.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Ellagic Acid; | 2008 |
Prevention and reduction of neural damage in ischemic strokes by w-(N,N'-diethylamino)-n-alkyl-3,4,5-trimethoxybenzoate compounds.
Topics: Animals; Aorta; Brain Ischemia; Calcium; Calcium Channel Blockers; Cells, Cultured; Cerebral Cortex; | 1995 |
Differential acetylcholine release mechanisms in the ischemic and non-ischemic myocardium.
Topics: Acetylcholine; Animals; Arterial Occlusive Diseases; Calcium Channel Blockers; Cats; Disease Models, | 2000 |
[Effects of psidium components on cytokine productions in helper T cells and type-I allergy].
Topics: Animals; Anti-Allergic Agents; Antibody Formation; Cells, Cultured; Cytokines; Depression, Chemical; | 2000 |
Either desipramine or TMB-8 suppresses cyanide-induced norepinephrine efflux from in vivo cardiac sympathetic nerves of cats.
Topics: Animals; Antidepressive Agents, Tricyclic; Calcium Channel Blockers; Cats; Cyanides; Desipramine; Di | 2000 |
Propyl gallate-contact sensitization and orally-induced tolerance.
Topics: 1-Propanol; Administration, Oral; Administration, Topical; Animals; Antioxidants; Chlorobenzenes; De | 1974 |