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gallic acid and Cancer of Liver

gallic acid has been researched along with Cancer of Liver in 19 studies

gallate : A trihydroxybenzoate that is the conjugate base of gallic acid.

Research Excerpts

ExcerptRelevanceReference
" Thus, in order to better comprehend the mechanism by which polyphenols regulate hTERT, the present study investigated the effects of the natural polyphenols Resveratrol, Gallic acid, and Kuromanin chloride on hTERT, Nrf2, and SIRT1 expression as well as oxidative stress in HepG2 hepatocellular carcinoma."8.31The effect of natural polyphenols Resveratrol, Gallic acid, and Kuromanin chloride on human telomerase reverse transcriptase (hTERT) expression in HepG2 hepatocellular carcinoma: role of SIRT1/Nrf2 signaling pathway and oxidative stress. ( Azadbakht, O; Behrouj, H; Ghojoghi, R; Moghadam, D; Sabaghan, M; Vakili, S; Veisi, A; Zarei, R; Zarezade, V, 2023)
"Nonalcoholic fatty liver disease (NAFLD) usually includes NAFL called simple hepatosteatosis and nonalcoholic steatohepatitis (NASH) called more steatohepatitis."5.91Phytochemical gallic acid alleviates nonalcoholic fatty liver disease via AMPK-ACC-PPARa axis through dual regulation of lipid metabolism and mitochondrial function. ( Liu, Z; Wang, E; Wang, J; Yang, L; Zhang, J; Zhang, W; Zhao, W, 2023)
"The global burden of hepatocellular carcinoma is increasing; actually, it is estimated as 750,000 new cases annually."5.46Gallic acid against hepatocellular carcinoma: An integrated scheme of the potential mechanisms of action from in vivo study. ( Aglan, HA; Ahmed, HH; El-Toumy, SA; Mahmoud, NS, 2017)
" Thus, in order to better comprehend the mechanism by which polyphenols regulate hTERT, the present study investigated the effects of the natural polyphenols Resveratrol, Gallic acid, and Kuromanin chloride on hTERT, Nrf2, and SIRT1 expression as well as oxidative stress in HepG2 hepatocellular carcinoma."4.31The effect of natural polyphenols Resveratrol, Gallic acid, and Kuromanin chloride on human telomerase reverse transcriptase (hTERT) expression in HepG2 hepatocellular carcinoma: role of SIRT1/Nrf2 signaling pathway and oxidative stress. ( Azadbakht, O; Behrouj, H; Ghojoghi, R; Moghadam, D; Sabaghan, M; Vakili, S; Veisi, A; Zarei, R; Zarezade, V, 2023)
"encapsulated GA-NC (gallic acid nanocomposite) in normal and hepatocellular carcinoma (HCC)-induced rats."3.88Improving Anti-Cancer Potentiality and Bioavailability of Gallic Acid by Designing Polymeric Nanocomposite Formulation ( Abd-Rabou, AA; Ahmed, HH; Galal, AF; Mehaya, FM; Shalby, AB, 2018)
"Nonalcoholic fatty liver disease (NAFLD) usually includes NAFL called simple hepatosteatosis and nonalcoholic steatohepatitis (NASH) called more steatohepatitis."1.91Phytochemical gallic acid alleviates nonalcoholic fatty liver disease via AMPK-ACC-PPARa axis through dual regulation of lipid metabolism and mitochondrial function. ( Liu, Z; Wang, E; Wang, J; Yang, L; Zhang, J; Zhang, W; Zhao, W, 2023)
"Syringic acid (SA) has been studied for its hepatoprotective, anti-inflammatory, immunomodulatory, free radical scavenging, and antioxidant activities."1.51Syringic acid triggers reactive oxygen species-mediated cytotoxicity in HepG2 cells. ( Ezhilarasan, D; Gheena, S, 2019)
"The global burden of hepatocellular carcinoma is increasing; actually, it is estimated as 750,000 new cases annually."1.46Gallic acid against hepatocellular carcinoma: An integrated scheme of the potential mechanisms of action from in vivo study. ( Aglan, HA; Ahmed, HH; El-Toumy, SA; Mahmoud, NS, 2017)
"Gallic acid was identified and quantified in EP extract and active fractions, EP."1.43Pro-apoptotic and cytotoxic effects of enriched fraction of Elytranthe parasitica (L.) Danser against HepG2 Hepatocellular carcinoma. ( Aranjani, JM; Biswas, S; Kumar, N; Lobo, R; Mathew, AE; Mathew, JE; Nandakumar, K; Varghese, S, 2016)
"The mechanism of human hepatoma BEL-7404 cells apoptosis induced by Galic acid from leaves of Phyllanthus emblica may be blocking G2/M period in cell life cycle, up-regulating the expression of Bax and down-regulating the expression of Bcl-2, that can decrease membrane potential of mitochondria,and triggered the caspases of activation of cascade and induced cell death."1.37[Study of galic acid extracted from the leaves of Phyllanthus emblica on apoptotic mechanism of human hepatocellular carcinoma cells BEL-7404]. ( Huang, JL; Zhong, ZG, 2011)
"In the present study, the human hepatoma cell line, HepG2, was used as a model to investigate the effect of antioxidant phenolic acids on enzymatic activity and expression of one of the major phase II sulfate conjugation enzymes, P-form phenolsulfotransferase (PST-P)."1.33Induction of phenolsulfotransferase expression by phenolic acids in human hepatoma HepG2 cells. ( Huang, SM; Yeh, CT; Yen, GC, 2005)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19902 (10.53)18.7374
1990's2 (10.53)18.2507
2000's5 (26.32)29.6817
2010's5 (26.32)24.3611
2020's5 (26.32)2.80

Authors

AuthorsStudies
Jurič, A1
Huđek Turković, A1
Brčić Karačonji, I1
Prđun, S1
Bubalo, D1
Durgo, K1
Moghadam, D1
Zarei, R1
Vakili, S1
Ghojoghi, R1
Zarezade, V1
Veisi, A1
Sabaghan, M1
Azadbakht, O1
Behrouj, H1
Zhang, J2
Zhang, W1
Yang, L1
Zhao, W1
Liu, Z1
Wang, E1
Wang, J1
Chen, C1
Zhang, S1
Zhang, R1
Sun, P1
Shi, C1
Abdalla, M1
Li, A1
Xu, J1
Du, W1
Liu, Y1
Tang, C1
Yang, Z1
Jiang, X1
Huang, CY1
Chang, YJ1
Wei, PL1
Hung, CS1
Wang, W1
Aglan, HA1
Ahmed, HH2
El-Toumy, SA1
Mahmoud, NS1
Galal, AF1
Shalby, AB1
Abd-Rabou, AA1
Mehaya, FM1
Gheena, S1
Ezhilarasan, D1
Kumar, N1
Biswas, S1
Mathew, AE1
Varghese, S1
Mathew, JE1
Nandakumar, K1
Aranjani, JM1
Lobo, R1
Zhong, ZG2
Huang, JL2
Liang, H1
Zhong, YN1
Zhang, WY1
Wu, DP1
Zeng, CL1
Wang, JS1
Wei, YH1
Dauer, A1
Hensel, A1
Lhoste, E1
Knasmüller, S1
Mersch-Sundermann, V1
Yeh, CT1
Huang, SM1
Yen, GC1
Zong, L1
Inoue, M2
Nose, M1
Kojima, K1
Sakaguchi, N1
Isuzugawa, K2
Takeda, T1
Ogihara, Y2
Kim, JA1
Kang, YS1
Lee, SH1
Lee, EH1
Yoo, BH1
Lee, YS1
Gong, G1
Waris, G1
Tanveer, R1
Siddiqui, A1
Krüger, B1
Nasemann, T1
Semenova, LP1
Nikol'skaia, TA1
Emanuel', NM1

Other Studies

19 other studies available for gallic acid and Cancer of Liver

ArticleYear
Cytotoxic activity of strawberry tree (
    Arhiv za higijenu rada i toksikologiju, 2022, Jul-07, Volume: 73, Issue:2

    Topics: Antineoplastic Agents; Antioxidants; Biphenyl Compounds; Caco-2 Cells; Carcinoma, Hepatocellular; Ca

2022
The effect of natural polyphenols Resveratrol, Gallic acid, and Kuromanin chloride on human telomerase reverse transcriptase (hTERT) expression in HepG2 hepatocellular carcinoma: role of SIRT1/Nrf2 signaling pathway and oxidative stress.
    Molecular biology reports, 2023, Volume: 50, Issue:1

    Topics: Carcinoma, Hepatocellular; Chlorides; Gallic Acid; Humans; Liver Neoplasms; NF-E2-Related Factor 2;

2023
Phytochemical gallic acid alleviates nonalcoholic fatty liver disease via AMPK-ACC-PPARa axis through dual regulation of lipid metabolism and mitochondrial function.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2023, Volume: 109

    Topics: AMP-Activated Protein Kinases; Animals; Carcinoma, Hepatocellular; Gallic Acid; Humans; Lipid Metabo

2023
    Theranostics, 2020, Volume: 10, Issue:26

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor;

2020
Methyl gallate, gallic acid-derived compound, inhibit cell proliferation through increasing ROS production and apoptosis in hepatocellular carcinoma cells.
    PloS one, 2021, Volume: 16, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Carcinoma, Hepatocell

2021
Gallic acid against hepatocellular carcinoma: An integrated scheme of the potential mechanisms of action from in vivo study.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2017, Volume: 39, Issue:6

    Topics: alpha-Fetoproteins; Animals; Apoptosis; Biomarkers, Tumor; Carcinoma, Hepatocellular; Diethylnitrosa

2017
Improving Anti-Cancer Potentiality and Bioavailability of Gallic Acid by Designing Polymeric Nanocomposite Formulation
    Asian Pacific journal of cancer prevention : APJCP, 2018, Nov-29, Volume: 19, Issue:11

    Topics: Animals; Biological Availability; Carcinoma, Hepatocellular; Diethylnitrosamine; Drug Compounding; F

2018
Syringic acid triggers reactive oxygen species-mediated cytotoxicity in HepG2 cells.
    Human & experimental toxicology, 2019, Volume: 38, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Cell Survival; Gallic Acid; Gene Ex

2019
Pro-apoptotic and cytotoxic effects of enriched fraction of Elytranthe parasitica (L.) Danser against HepG2 Hepatocellular carcinoma.
    BMC complementary and alternative medicine, 2016, Oct-26, Volume: 16, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Survival; Gallic Acid;

2016
[The effect of gallic acid extracted from leaves of Phyllanthus emblica on apoptosis of human hepatocellular carcinoma BEL-7404 cells].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2009, Volume: 32, Issue:7

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Prol

2009
[Study of galic acid extracted from the leaves of Phyllanthus emblica on apoptotic mechanism of human hepatocellular carcinoma cells BEL-7404].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2011, Volume: 34, Issue:2

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Carcino

2011
Genotoxic and antigenotoxic effects of catechin and tannins from the bark of Hamamelis virginiana L. in metabolically competent, human hepatoma cells (Hep G2) using single cell gel electrophoresis.
    Phytochemistry, 2003, Volume: 63, Issue:2

    Topics: Anthocyanins; Antineoplastic Agents, Phytogenic; Benzo(a)pyrene; Carcinoma, Hepatocellular; Catechin

2003
Induction of phenolsulfotransferase expression by phenolic acids in human hepatoma HepG2 cells.
    Journal of agricultural and food chemistry, 2005, Jun-15, Volume: 53, Issue:12

    Topics: Arylsulfotransferase; Carcinoma, Hepatocellular; Cell Division; Enzyme Induction; Gallic Acid; Gene

2005
Metabolic fate of gallic acid orally administered to rats.
    Biological & pharmaceutical bulletin, 1999, Volume: 22, Issue:3

    Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Drug Administration Routes; Gal

1999
Glibenclamide induces apoptosis through inhibition of cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channels and intracellular Ca(2+) release in HepG2 human hepatoblastoma cells.
    Biochemical and biophysical research communications, 1999, Aug-11, Volume: 261, Issue:3

    Topics: Apoptosis; Caco-2 Cells; Calcium; Chlorides; Cystic Fibrosis Transmembrane Conductance Regulator; Da

1999
Different generation of inhibitors against gallic acid-induced apoptosis produces different sensitivity to gallic acid.
    Biological & pharmaceutical bulletin, 2001, Volume: 24, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Chromatography, Gel; Culture Media, Condition

2001
Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Aug-14, Volume: 98, Issue:17

    Topics: Acetylcysteine; Antioxidants; Calcium; Calcium Signaling; Carcinoma, Hepatocellular; Chelating Agent

2001
[Acanthosis nigricans in liver hamartoma and excessive increase of serum gallic acids: a hitherto undescribed combination].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1973, Volume: 24, Issue:8

    Topics: Acanthosis Nigricans; Adolescent; Bilirubin; Biopsy; Cell Nucleus; Cytoplasmic Granules; Female; Gal

1973
[Oxidation phosphorylation and respiration in liver mitochondria and solid hepatoma of mice suppressed by propylgallate].
    Doklady Akademii nauk SSSR, 1965, Jul-21, Volume: 163, Issue:3

    Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Gallic Acid; Liver Neoplasms; Mice; Neoplasms, Exp

1965