gallic acid has been researched along with Alzheimer Disease in 28 studies
gallate : A trihydroxybenzoate that is the conjugate base of gallic acid.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gallic acid (GA) is a phenolic acid with anti-amyloidogenic activity against Aβ in buffered solutions." | 1.62 | Influence of in vitro neuronal membranes on the anti-amyloidogenic activity of gallic acid: Implication for the therapy of Alzheimer's disease. ( Andrade, S; Loureiro, JA; Pereira, MDC, 2021) |
| "Gallic acid has been shown to both modulate factors leading to the onset of neurodegenerative disorders, as well as directly inhibit amyloid formation." | 1.56 | Gallic acid oxidation products alter the formation pathway of insulin amyloid fibrils. ( Sakalauskas, A; Smirnovas, V; Ziaunys, M, 2020) |
| "To date, there is no effective Alzheimer's disease (AD)-modifying therapy." | 1.46 | Combination therapy with octyl gallate and ferulic acid improves cognition and neurodegeneration in a transgenic mouse model of Alzheimer's disease. ( Koyama, N; Maeda, M; Mori, T; Segawa, T; Tan, J; Town, T, 2017) |
| "The cascade of events that occurs in Alzheimer's disease involving oxidative stress and the reduction in cholinergic transmission can be better addressed by multifunctional drugs than cholinesterase inhibitors alone." | 1.38 | Carbamate derivatives of indolines as cholinesterase inhibitors and antioxidants for the treatment of Alzheimer's disease. ( Finkin-Groner, E; Ginsburg, I; Lerman, L; Nudelman, A; Shalom, H; Weill, T; Weinstock, M; Yanovsky, I; Zaikin, A; Zeeli, S, 2012) |
| " Prefibrillar species were more toxic than mature fibrils." | 1.38 | Dendrimers reduce toxicity of Aβ 1-28 peptide during aggregation and accelerate fibril formation. ( Correa, J; Fernandez-Megia, E; Fernandez-Villamarin, M; Ionov, M; Klajnert, B; Riguera, R; Sousa-Herves, A; Wasiak, T, 2012) |
| "The present study explored the bioavailability and brain deposition of a grape seed polyphenolic extract (GSPE) previously found to attenuate cognitive deterioration in a mouse model of Alzheimer's disease (AD)." | 1.35 | Bioavailability of gallic acid and catechins from grape seed polyphenol extract is improved by repeated dosing in rats: implications for treatment in Alzheimer's disease. ( Cooper, B; Ferruzzi, MG; Ho, L; Janle, EM; Lobo, JK; Pasinetti, GM; Simon, JE; Weaver, C; Welch, C; Wu, QL, 2009) |
| "Our previous studies indicated that Alzheimer's disease (AD) related amyloid beta peptide (Abeta) significantly altered muscarinic cholinergic receptor (mChR) signaling on the level of G protein regulated phospholipase C (PLC) leading to the lower formation of inositol-1,4,5-triphosphate (IP3) and diacylglycerol (DAG)." | 1.33 | Alzheimer's disease related peptides affected cholinergic receptor mediated poly(ADP-ribose) polymerase activity in the hippocampus. ( Adamczyk, A; Jeśko, H; Strosznajder, RP, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (10.71) | 29.6817 |
| 2010's | 15 (53.57) | 24.3611 |
| 2020's | 10 (35.71) | 2.80 |
| Authors | Studies |
|---|---|
| Yanovsky, I | 1 |
| Finkin-Groner, E | 1 |
| Zaikin, A | 1 |
| Lerman, L | 1 |
| Shalom, H | 1 |
| Zeeli, S | 1 |
| Weill, T | 1 |
| Ginsburg, I | 1 |
| Nudelman, A | 1 |
| Weinstock, M | 1 |
| Liu, Y | 2 |
| Pukala, TL | 1 |
| Musgrave, IF | 1 |
| Williams, DM | 1 |
| Dehle, FC | 1 |
| Carver, JA | 1 |
| Umar, T | 1 |
| Gusain, S | 1 |
| Raza, MK | 1 |
| Shalini, S | 1 |
| Kumar, J | 1 |
| Tiwari, M | 1 |
| Hoda, N | 1 |
| Kubo, K | 1 |
| Watanabe, H | 1 |
| Kumeta, H | 1 |
| Aizawa, T | 1 |
| Seki, C | 1 |
| Nakano, H | 1 |
| Tokuraku, K | 1 |
| Uwai, K | 1 |
| Andrade, S | 2 |
| Loureiro, JA | 2 |
| Pereira, MDC | 1 |
| Li, X | 1 |
| Zhang, X | 1 |
| Xing, R | 1 |
| Qi, F | 1 |
| Dong, J | 1 |
| Li, D | 1 |
| Tian, X | 1 |
| Yu, B | 1 |
| Huang, M | 1 |
| Zhang, L | 1 |
| Yuan, X | 1 |
| Yang, Y | 1 |
| Wu, H | 1 |
| Zang, L | 1 |
| Mao, X | 1 |
| Sui, R | 1 |
| Araújo, AR | 1 |
| Correa, J | 2 |
| Dominguez-Arca, V | 1 |
| Reis, RL | 1 |
| Fernandez-Megia, E | 2 |
| Pires, RA | 1 |
| Xu, S | 1 |
| Sun, Y | 1 |
| Dong, X | 1 |
| Huo, X | 1 |
| Liu, H | 1 |
| Wang, S | 1 |
| Yin, S | 1 |
| Yin, Z | 1 |
| Dang, Y | 1 |
| Wang, F | 1 |
| Li, L | 1 |
| Lai, Y | 1 |
| Xu, Z | 1 |
| Xiong, Z | 1 |
| Zhang, A | 1 |
| Tian, Y | 1 |
| Ding, C | 1 |
| Zhang, W | 1 |
| Fan, Q | 1 |
| Wang, X | 1 |
| Zhang, Z | 1 |
| Fu, Y | 1 |
| Liu, L | 1 |
| Wang, P | 1 |
| Ma, H | 2 |
| Seeram, NP | 1 |
| Zheng, J | 1 |
| Zhou, F | 1 |
| Sakalauskas, A | 1 |
| Ziaunys, M | 1 |
| Smirnovas, V | 1 |
| Mori, T | 3 |
| Koyama, N | 2 |
| Yokoo, T | 1 |
| Segawa, T | 2 |
| Maeda, M | 2 |
| Sawmiller, D | 2 |
| Tan, J | 3 |
| Town, T | 2 |
| Ramalho, MJ | 1 |
| Pereira, MC | 1 |
| Yao, J | 1 |
| Gao, X | 1 |
| Sun, W | 1 |
| Yao, T | 1 |
| Shi, S | 1 |
| Ji, L | 1 |
| Zhang, SQ | 1 |
| Li, S | 1 |
| Rezai-Zadeh, K | 1 |
| Hou, H | 1 |
| Zhou, S | 1 |
| Shytle, D | 1 |
| Giunta, B | 1 |
| Fernandez, F | 1 |
| Kim, E | 1 |
| Jung, YS | 1 |
| Kim, H | 1 |
| Kim, JS | 1 |
| Park, M | 1 |
| Jeong, J | 1 |
| Lee, SK | 1 |
| Yoon, HG | 1 |
| Hwang, GS | 1 |
| Namkoong, K | 1 |
| Sylla, T | 1 |
| Pouységu, L | 1 |
| Da Costa, G | 1 |
| Deffieux, D | 1 |
| Monti, JP | 1 |
| Quideau, S | 1 |
| Chan, S | 1 |
| Kantham, S | 1 |
| Rao, VM | 1 |
| Palanivelu, MK | 1 |
| Pham, HL | 1 |
| Shaw, PN | 1 |
| McGeary, RP | 1 |
| Ross, BP | 1 |
| Ferruzzi, MG | 1 |
| Lobo, JK | 1 |
| Janle, EM | 1 |
| Cooper, B | 1 |
| Simon, JE | 1 |
| Wu, QL | 1 |
| Welch, C | 1 |
| Ho, L | 1 |
| Weaver, C | 1 |
| Pasinetti, GM | 1 |
| Lecanu, L | 1 |
| Tillement, L | 1 |
| McCourty, A | 1 |
| Rammouz, G | 1 |
| Yao, W | 1 |
| Greeson, J | 1 |
| Papadopoulos, V | 1 |
| Skrzypczak-Jankun, E | 1 |
| Jankun, J | 1 |
| Cirillo, G | 1 |
| Kraemer, K | 1 |
| Fuessel, S | 1 |
| Puoci, F | 1 |
| Curcio, M | 1 |
| Spizzirri, UG | 1 |
| Altimari, I | 1 |
| Iemma, F | 1 |
| Klajnert, B | 1 |
| Wasiak, T | 1 |
| Ionov, M | 1 |
| Fernandez-Villamarin, M | 1 |
| Sousa-Herves, A | 1 |
| Riguera, R | 1 |
| Jeong, HR | 1 |
| Jo, YN | 1 |
| Jeong, JH | 1 |
| Jin, DE | 1 |
| Song, BG | 1 |
| Choi, SJ | 1 |
| Shin, DH | 1 |
| Heo, HJ | 1 |
| Lee, HJ | 1 |
| Seong, YH | 1 |
| Bae, KH | 1 |
| Kwon, SH | 1 |
| Kwak, HM | 1 |
| Nho, SK | 1 |
| Kim, KA | 1 |
| Hur, JM | 1 |
| Lee, KB | 1 |
| Kang, YH | 1 |
| Song, KS | 1 |
| Adamczyk, A | 1 |
| Jeśko, H | 1 |
| Strosznajder, RP | 1 |
28 other studies available for gallic acid and Alzheimer Disease
| Article | Year |
|---|---|
Carbamate derivatives of indolines as cholinesterase inhibitors and antioxidants for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Antioxidants; Apoptosis; Carbamates; Chickens; Cholinesterase Inhibitors | 2012 |
Gallic acid is the major component of grape seed extract that inhibits amyloid fibril formation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Gallic Acid; Grape Seed Extract; Mice; Protein Fo | 2013 |
Naphthalene-triazolopyrimidine hybrid compounds as potential multifunctional anti-Alzheimer's agents.
Topics: Alzheimer Disease; Anti-Anxiety Agents; Drug Design; Humans; Naphthalenes | 2019 |
Chemical analysis of amyloid β aggregation inhibitors derived from Geranium thunbergii.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Geranium; Humans; Neurons; Peptide Fragments; Pla | 2022 |
Influence of in vitro neuronal membranes on the anti-amyloidogenic activity of gallic acid: Implication for the therapy of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Gallic Acid; Humans; Kinetics; Liposomes; Peptide Fragment | 2021 |
Syringic acid demonstrates promising protective effect against tau fibrillization and cytotoxicity through regulation of endoplasmic reticulum stress-mediated pathway as a prelude to Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Apoptosis; Endoplasmic Reticulum Stress; Gallic Acid; Humans; Kinetics; | 2021 |
Functional Gallic Acid-Based Dendrimers as Synthetic Nanotools to Remodel Amyloid-β-42 into Noncytotoxic Forms.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Cell Line; Cell Survival; Dendrimers; Gallic Acid | 2021 |
Design of Gallic Acid-Glutamine Conjugate and Chemical Implications for Its Potency Against Alzheimer's Amyloid-β Fibrillogenesis.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Gallic Acid; Glutamine; Humans; Molecular Dynamic | 2022 |
The inhibitory effect and mechanism of small molecules on acetic anhydride-induced BSA acetylation and aggregation.
Topics: Acetic Anhydrides; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Amyloidogenic Proteins; Apigen | 2023 |
An activatable near-infrared fluorescent probe for methylglyoxal imaging in Alzheimer's disease mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Cell Line, Tumor; Fluorescent Dye | 2020 |
Ginnalin A Inhibits Aggregation, Reverses Fibrillogenesis, and Alleviates Cytotoxicity of Amyloid β(1-42).
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Cell Survival; Circular Dichroism; Deoxyglucose; | 2020 |
Gallic acid oxidation products alter the formation pathway of insulin amyloid fibrils.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Amyloidogenic Proteins; Gallic Acid; Humans; Insu | 2020 |
Gallic acid is a dual α/β-secretase modulator that reverses cognitive impairment and remediates pathology in Alzheimer mice.
Topics: ADAM10 Protein; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secreta | 2020 |
Combination therapy with octyl gallate and ferulic acid improves cognition and neurodegeneration in a transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Co | 2017 |
Interaction of natural compounds with biomembrane models: A biophysical approach for the Alzheimer's disease therapy.
Topics: Alzheimer Disease; Caffeine; Cholesterol; Dimyristoylphosphatidylcholine; Gallic Acid; Humans; Lipid | 2019 |
Molecular hairpin: a possible model for inhibition of tau aggregation by tannic acid.
Topics: Alzheimer Disease; Amino Acid Sequence; Gallic Acid; Humans; Molecular Docking Simulation; Molecular | 2013 |
Octyl gallate markedly promotes anti-amyloidogenic processing of APP through estrogen receptor-mediated ADAM10 activation.
Topics: ADAM Proteins; ADAM10 Protein; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor | 2013 |
Metabolomic signatures in peripheral blood associated with Alzheimer's disease amyloid-β-induced neuroinflammation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Biomarkers; Disease Models, Animal; Encephalitis; | 2014 |
Gallotannins and Tannic Acid: First Chemical Syntheses and In Vitro Inhibitory Activity on Alzheimer's Amyloid β-Peptide Aggregation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Gallic Acid; Molecular Structure; Polyphenols; Tannins | 2015 |
Metal chelation, radical scavenging and inhibition of Aβ₄₂ fibrillation by food constituents in relation to Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Brain; Catechin; Chelating Agents; Curcumin; Free Radical | 2016 |
Bioavailability of gallic acid and catechins from grape seed polyphenol extract is improved by repeated dosing in rats: implications for treatment in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Biological Availability; Brain; Catechin; Drug Administration Schedule; | 2009 |
Dimethyl-carbamic acid 2,3-Bis-Dimethylcarbamoyloxy-6-(4-Ethyl-Piperazine-1-Carbonyl)-phenyl ester: a novel multi-target therapeutic approach to neuroprotection.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Brain; Carbam | 2010 |
Theaflavin digallate inactivates plasminogen activator inhibitor: could tea help in Alzheimer's disease and obesity?
Topics: Alzheimer Disease; Biflavonoids; Catechin; Electrophoresis, Polyacrylamide Gel; Gallic Acid; Humans; | 2010 |
Biological activity of a gallic acid-gelatin conjugate.
Topics: Acetylcholinesterase; Alzheimer Disease; Antineoplastic Agents; Antioxidants; Carcinoma, Renal Cell; | 2010 |
Dendrimers reduce toxicity of Aβ 1-28 peptide during aggregation and accelerate fibril formation.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Cell Line; Cell Survival; Cricetinae; Cr | 2012 |
Antiamnesic effects of ethyl acetate fraction from chestnut (Castanea crenata var. dulcis) inner skin on Aβ(25-35)-induced cognitive deficits in mice.
Topics: Acetates; Alzheimer Disease; Amyloid beta-Peptides; Animals; Catechin; Cell Survival; Chromatography | 2012 |
Beta-secretase (BACE1) inhibitors from Sanguisorbae Radix.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Dose-Response | 2005 |
Alzheimer's disease related peptides affected cholinergic receptor mediated poly(ADP-ribose) polymerase activity in the hippocampus.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium Channel Blockers; Calcium Channels; Carba | 2005 |