galanin-like-peptide and Mental-Disorders

Topics: Alzheimer Disease; Amino Acid Sequence; Animals; Digestive System; Digestive System Physiological Phenomena; Galanin-Like Peptide; Humans; Mental Disorders; Molecular Sequence Data; Muscle, Smooth; Nerve Tissue Proteins; Pain; Pancreas; Pituitary Hormones; Receptors, Galanin; Receptors, Neuropeptide

During early telencephalic development, intricate processes of regional patterning and neural stem cell (NSC) fate specification take place. However, our understanding of these processes in primates, including both conserved and species-specific features, remains limited. Here, we profiled 761,529 single-cell transcriptomes from multiple regions of the prenatal macaque telencephalon. We deciphered the molecular programs of the early organizing centers and their cross-talk with NSCs, revealing primate-biased galanin-like peptide (

Topics: Animals; Brain Neoplasms; Female; Galanin-Like Peptide; Gene Expression Regulation, Developmental; Macaca; Mental Disorders; Nervous System Diseases; Neural Stem Cells; Neurogenesis; Neurons; Pregnancy; Telencephalon