galactosamine has been researched along with Chemical and Drug Induced Liver Injury in 840 studies
*Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 276 (32.86) | 18.7374 |
| 1990's | 136 (16.19) | 18.2507 |
| 2000's | 163 (19.40) | 29.6817 |
| 2010's | 205 (24.40) | 24.3611 |
| 2020's | 60 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Hu, K; Huang, J; Li, L; Shen, Y; Tang, L; Wang, Y; Wen, S; Xiao, L; Yang, Y; Zhang, L | 1 |
| Huang, K; Kong, L; Liu, K; Meng, Q; Sun, H; Wang, C; Wang, L; Wang, S; Wang, X; Wu, J | 1 |
| An, S; Chen, Z; Fang, H; Huang, Q; Li, L; Wang, J; Wu, J; Yang, H; Zeng, Z; Zhang, Y | 1 |
| Chen, Y; Cheng, Y; Dai, F; Gu, T; Jiang, H; Tang, L; Wen, X; Zhan, Z; Zhang, T | 1 |
| Chen, X; Li, R; Sun, X; Tao, K; Yang, W; Zhang, P | 1 |
| He, XJ; Huang, S; Liu, MH; Xie, B | 1 |
| Li, L; Si, G; Wang, C; Zha, H; Zhang, H | 1 |
| Ding, Y; Ge, Y; Sun, Z; Tong, Z; Wang, W; Xu, Q; Zhang, S; Zhou, H; Zhou, L | 1 |
| Dong, S; Jia, M; Li, S; Liu, G; Mu, W; Wang, Q; Yang, J | 1 |
| Gu, S; He, G; Li, M; Li, R; Sun, J; Zhao, Q; Zhao, Y; Zong, Y | 1 |
| Bayrak, BB; Mahmarzayeva, D; Sacan, O; Turkyilmaz, IB; Yanardag, R | 1 |
| Ai, G; Chen, J; Dou, Y; Huang, R; Li, Y; Lin, Z; Liu, Y; Qu, C; Su, Z; Wu, X; Xian, Y; Zhong, L | 1 |
| Chen, Y; Fu, Y; Li, P; Sun, Y; Wang, J; Wang, X; Wu, H; Wu, Z; Yang, Z; Ye, Y; Zhou, E | 1 |
| Jiang, L; Li, F; Liao, X; Ming, J; Wu, S; Zhao, J | 1 |
| Bai, LY; Chen, QF; Gan, S; Li, YH; Luo, QQ; Qu, XQ; Shi, QQ; Zheng, SY; Zhou, XY | 1 |
| Chen, Y; Deng, Z; Huang, J; Shi, X; Wang, J; Ye, C; Yu, Y; Zhang, B | 1 |
| Guo, X; Li, P; Liu, G; Liu, Q; Liu, T; Yang, J | 1 |
| Chen, Y; Fu, Y; He, L; Sun, Y; Wang, J; Wang, X; Wu, H; Yang, Z; Ye, Y; Zhou, E; Zhou, Q | 1 |
| Bogunia, E; Czekaj, P; Grajoszek, A; Hermyt, M; Kolanko, E; Król, M; Limanówka, Ł; Michalik, M; Pająk, J; Prusek, A; Sikora, B; Skubis-Sikora, A | 1 |
| Er, B; Oner, P; Orhan, C; Sahin, K | 1 |
| Ahmad, FU; Baig, MS; Hussain, L; Khalid, AA; Khurshid, U; Lodhi, AH; Mehdi, S; Sidiq, SS | 1 |
| Abd El-Haleim, EA; Ahmed, LA; Atwa, AM; Didamoony, MA | 1 |
| Hu, J; Liu, S; Wei, F; Yang, Z; Yin, R | 1 |
| Hu, K; Li, L; Lin, L; Ma, Y; Shao, R; Tang, L; Yang, Y; Zhang, L; Zhang, X; Zhu, M | 1 |
| Cao, X; Chang, Y; Fan, Y; He, J; Ouyang, H; Wei, S; Zhang, M; Zhu, Y | 1 |
| Ding, Q; Liu, Q; Liu, X; Song, S; Yan, X; Zhang, Y; Zong, X | 1 |
| Jiang, M; Li, X; Li, Y; Wang, J; Wu, T; Wu, Z; Xie, Y; Yang, Z; Yu, H; Zhou, E | 1 |
| Chen, H; Chen, X; Gao, HY; Ge, CH; Ge, ZQ; Li, CY; Li, DX; Li, YT; Liu, K; Liu, X; Ren, GM; Wang, T; Wang, Y; Xiang, SS; Xiao, Y; Yang, XM; Yin, RH; Yu, M; Zhan, YQ; Zhang, W; Zhao, K | 1 |
| Liu, Z; Shen, Z; Tian, Q; Wang, G; Yang, L; Zhang, F; Zhang, Y | 1 |
| Huang, J; Li, L; Shao, R; Shen, Y; Tang, L; Yang, Y; Zhang, L; Zhu, M | 1 |
| Feng, X; Guang, C; Li, Y; Qiu, F; Zhao, N | 1 |
| Gao, ZH; Li, RF; Li, SQ; Li, YY; Liu, WY; Wang, HW; Wang, JG; You, M | 1 |
| Bian, X; Jiang, H; Jiang, X; Li, L; Li, Y; Lu, Y; Lv, L; Shen, J; Wang, K; Wang, Q; Wu, J; Xie, J; Yan, R; Yang, L; Ye, J | 1 |
| Jiang, K; Tian, L; Zhang, Z | 1 |
| Fan, K; Xie, ML; Zhao, Y; Zhou, RJ | 1 |
| Fang, XY; Li, YC; Lu, SF; Ming, B; Shen, JD; Wang, BY; Xu, EP; Zhu, LL | 1 |
| Cheng, J; Ding, L; Feng, H; Han, L; Jin, M; Li, Z; Liu, G; Qin, H; Shen, B; Tian, Y; Wang, Q; Zhao, L | 1 |
| Bian, X; Jiang, H; Jiang, X; Li, L; Li, Y; Lu, Y; Lv, L; Shen, J; Wang, K; Wang, Q; Wu, J; Wu, W; Xie, J; Yan, R; Yang, L; Ye, J | 1 |
| Chen, X; Kachman, SD; Li, X; Liu, B; Lu, Y; Muthuraj, PG; Natarajan, SK; Pattabiraman, M; Yu, J; Zempleni, J | 1 |
| Dai, J; Gong, X; Huang, J; Li, L; Lin, L; Peng, X; Shen, Y; Tang, L; Wan, J; Yang, Y; Zhang, L | 1 |
| Deng, H; Gu, ST; Hao, L; Huang, X; Liu, MW; Wang, X | 1 |
| Cai, E; Liu, S; Sun, X; Zhang, T; Zhao, Y; Zhu, H | 1 |
| Chang, K; Fang, DQ; Li, LJ; Li, YT; Shi, D; van der Reis, A; Xie, JJ; Xu, QM; Yang, LY; Zha, H | 1 |
| Chen, S; Feng, Z; Lao, L; Lin, X; Pang, L; Pang, X; Qiao, Q; Vonglorkham, S; Wang, D; Wei, J | 1 |
| Bi, H; Cao, P; Chen, N; Chu, S; Guo, Q; He, W; Li, F; Li, X; Niu, Z; Sun, X; Zhang, Z | 1 |
| Han, CK; Hyun, SH; In, G; Jung, HR; Kang, MJ; Kim, SW; Kyung, JS; Lee, YY; Moon, SJ; Park, CK; Yi, EC; Youn, SH | 1 |
| Chen, M; Huang, J; Li, L; Liu, L; Shen, Y; Tang, L; Wang, Z; Zhang, L | 1 |
| Aasen, T; Abdul Moin, NI; Abdul Wafi, S; Aboukameel, A; Abu-Bakar, N; Acharya, A; Ackermans, L; Adaramoye, O; Adarsh, KV; Adeosun, WA; Ahmad, NH; Ahmadi, F; Akanni, O; Akbar, M; Akbulak, RO; Akev, N; Akkaya, Ö; Al-Rashed, S; AlAbbad, S; Alabi, O; Alappat, BJ; Alcalá, S; Alcoutlabi, M; Aleppo, G; Alexander Ross, JB; Alexander, JH; Alexander, R; Alias, A; Alimba, C; Alken, FA; Allan, R; Alpers, M; Alsbou, EM; Amarasiri, SS; An, T; Anastasiadis, F; Anastassiadou, M; Anderson, KC; Andronikos, P; Anheyer, D; Annapurna, K; Anorlu, RI; Anten, MM; Anthopoulos, TD; Araujo-Castillo, RV; Aravamudhan, S; Arawwawala, LDAM; Arulsamy, N; Arunamata, A; Asghar, A; Asiri, AM; Aslanidou, T; Astrakhantseva, IV; Astutik, E; Attanayake, AP; Atwater, BD; Audureau, E; Augusto, S; Bakare, A; Banach, M; Bandelier, P; Banerjee, S; Barral, M; Bascuñán, J; Bates, FS; Bauer, NJC; Bayrak, BB; Beck, RW; Beckervordersantforth, J; Beeri, R; Begum, R; Beldi-Ferchiou, A; Bellingham, G; Ben-Tal, N; Bendib, I; Bergenstal, RM; Berger, MF; Bernasconi, G; Berry, S; Beuvon, F; Bi, WJ; Bi, Z; Bianconi, V; Bibi, I; Blank, BR; Bliemeister, E; Bobkowski, W; Bode, AM; Booth, CM; Bose, U; Boyd, K; Brancato, A; Brenmoehl, J; Brogi, E; Bronzo, P; Brooks, T; Brown, D; Brown, DN; Bruce, D; Buan, MEM; Bueno-Hernández, F; Bugielski, B; Bulavaitė, A; Buscagan, TM; Buxton, R; Caffaro, MM; Cai, Q; Cai, X; Cai, Y; Calhoun, P; Callander, N; Cambier, S; Camparo, P; Canales-Vargas, EJ; Canham, K; Cantu, J; Cao, J; Cao, JW; Cao, P; Cao, T; Cao, X; Caravella, BA; Carcadea, E; Carè, J; Carmichael, P; Carrasco Cabrera, L; Carteaux, G; Carvalho, PDS; Casarez, E; Cazorla, M; Celestrin, CP; Chakraborty, NK; Chan, B; Chandarlapaty, S; Chandgude, AL; Chang, CC; Chang, JH; Chang, X; Chang, Y; Chankhanittha, T; Chantanis, S; Chapovetsky, A; Chavan, S; Chen, B; Chen, D; Chen, F; Chen, G; Chen, H; Chen, J; Chen, K; Chen, KJ; Chen, KP; Chen, L; Chen, MA; Chen, Q; Chen, S; Chen, W; Chen, WF; Chen, X; Chen, Y; Cheng, D; Cheng, J; Cheng, Q; Cheon, GJ; Chiu, SC; Cho, CH; Cho, J; Choi, H; Choi, JS; Choi, YH; Christie, P; Chu, CH; Chu, Y; Chung, DH; Chung, F; Cline, JP; Cohen, A; Cohen, AD; Cohen, NJ; Comen, E; Compter, I; Cong, J; Cong, Z; Cooper, A; Cornud, F; Costa, C; Costa, S; Covey, A; Cowan, AM; Cramer, H; Cruz-Rivera, C; Cui, J; Cui, M; Cui, Y; Cui, YH; Culquichicón, C; Cushman, T; D'Auria, SJ; da Silva, J; Dalgediene, I; Danenberg, HD; Das, S; Dasgupta, K; Daubit, IM; de Oliveira, PD; de Prost, N; De Ruysscher, D; Dearman, K; Decato, D; Delfau-Larue, MH; Deng, L; Dhakate, SR; Dharuman, V; Di Costanzo, N; Dickler, MN; Dinehart, EE; Ding, D; Dinh, TK; Divya, KP; Djifack Tadongfack, T; Do, T; Domínguez-Roldan, R; Domínguez-Zambrano, E; Dömling, A; Donato, MD; Dong, JH; Dong, W; Dong, X; Dong, XR; Dong, Y; Dong, Z; Downs, M; Drutskaya, MS; Du, B; Du, F; Du, H; Du, L; Du, X; Duan, Z; Duangthip, D; Dunstand-Guzmán, E; Duong, F; Eckert, DJ; Edelhäuser, BAH; Eekers, DBP; Efendi, F; Efraimidis, P; Ehrenberg, H; Ehsanbakhsh, Z; Eickholt, C; Eksterowicz, J; El Mobadder, M; El-Araby, IE; El-Magd, MA; El-Tarabany, MS; Elgorban, AM; Engelmann, D; English, KL; Esfandiari, H; Eslami, B; Espinosa-Cuevas, A; Eswara, S; Faber, E; Fan, XH; Fan, Y; Fang, J; Fang, Z; Fantin, VR; Fei, P; Feng, G; Feng, H; Feng, J; Feng, X; Feng, XJ; Fennell, TR; Fernández-Moreira, V; Ferraz, ABF; Ferreras, KN; Flores, K; Flores-Pérez, I; Flox, C; Fluharty, FL; Fokouong Tchoffo, E; Folefack, GO; Foroutan, T; Fort, D; Fourati, S; Fousas, S; Frapard, T; Freguia, S; Friedman, DJ; Friedman, LS; Fu, D; Fu, Q; Fu, Y; Fujinami, S; Furihata, K; Gal, RL; Gan, H; Gao, C; Gao, F; Gao, R; Gao, SS; Gao, W; Gao, XC; Gao, Y; Gao, Z; Garozi, L; Ge, J; Georgiopoulos, A; Gerakiou, K; Ghazimirsaeed, SM; Ghazimirsaeed, ST; Gimeno, MC; Gjestad, R; Glurich, I; Goetchius, E; Goland, S; Goldstein, S; Gonçalves, CM; Gonçalves, H; Gong, Q; Gonzalez, D; Goplen, FK; Gorshkova, EN; Gotsman, I; Govindasamy, V; Granger, CB; Greco, L; Grigoriadou-Skouta, E; Grigoropoulos, P; Grivicich, I; Gromov, NV; Gruber, S; Grytczuk, M; Grzech-Leśniak, K; Gu, L; Gu, S; Gu, Z; Guadagnini, D; Guan, H; Guilliams, M; Guo, J; Guo, L; Gupta, A; Gupta, SK; Gurzu, S; Gutleb, AC; Haban, A; Hablitz, JJ; Hadisuyatmana, S; Hahn, S; Haiges, R; Hallal-Calleros, C; Hamed, M; Hammad, N; Hammer, N; Han, C; Hao, Y; Harnett, J; Has, EMM; Hassanpour, K; Hatzopoulos, D; Hawaldar, R; He, X; He, Y; He, YY; He, Z; Heberman, D; Heckl, D; Hegde, H; Henson, MA; Hernández-Velázquez, VM; Herrera, E; Hijazi, Z; Hirayama, K; Hirth, JM; Hoeben, A; Hohnloser, SH; Hong, M; Hood, K; Hoplock, LB; Hopman, WM; Horlbogen, LM; Hossein Rashidi, B; Hou, G; Hou, H; Hou, J; Hou, Y; Hu, J; Hu, W; Hu, X; Hua, W; Huang, G; Huang, H; Huang, J; Huang, T; Huang, W; Huang, Y; Huang, YD; Huang, Z; Hudis, CA; Hue, S; Huo, J; Hussain, M; Hvas, AM; Ichii, T; Ide Zeuna, J; Ilyas, S; Inoue, T; Iranzo, A; Irfan, M; Iwasa, Y; Iwashita, Y; Izgorodina, EI; J R, A; Jaber, WA; Jaborek, JR; Jacobus, SJ; Jadeja, SD; Jafarabadi, M; Jalan, D; Jamil, MI; Jarrah, S; Jarvis, D; Jayatilaka, KAPW; Jemal-Turki, A; Jeon, YK; Jeong, N; Jeong, SH; Jeong, SY; Jermy, M; Jhaveri, K; Ji, H; Ji, K; Ji, RY; Jiang, F; Jiang, J; Jiang, X; Jiang, Y; Jiao, Q; Jilani, K; Jiménez-Guerrero, P; Jin, L; Jo, YH; Johnson, JG; Johnson, ML; Jones, WS; Jose, S; Jularic, M; Jung, I; Jung, YJ; Jungen, C; Junttila, MR; Kache, S; Kahanovitch, U; Kalantzi, KI; Kallio, T; Kamnoedboon, P; Kang, CH; Kang, H; Kang, J; Kang, KW; Kapoor, P; Karmakar, D; Kartalis, A; Kauranen, P; Kazocina, A; Keikha, F; Keltai, M; Kershaw, SV; Kettani, M; Khalvati, S; Khandhar, S; Khosla, N; Kiely, CJ; Kim, CC; Kim, H; Kim, MJ; Kim, Y; Kim, YH; Kim, YT; Kimoto, E; Kiyu, A; Klatt, N; Kobayashi, M; Koh, J; Köhler, R; Kondadasula, SV; Kong, H; Kong, W; Kong, X; Kotidis, A; Kotwal, A; Kouvari, M; Kozhinov, AN; Kruger, D; Kuang, S; Kuang, Y; Kubota, M; Kuklik, P; Kumar, P; Kumar, SK; Kuo, YF; Kurup, SP; Kusuhara, H; Kuswanto, H; Lacouture, ME; Lambin, P; Lang, CC; Langroudi, FH; Lanman, RB; Larsen, OH; Laskin, J; Le, VH; Leach, M; Lee, BG; Lee, DF; Lee, DS; Lee, HJ; Lee, SB; Lee, YA; Lei, Y; Lekashvili, O; Lelj, F; Lemin, AS; Lemoine, J; Leuschner, R; Li, B; Li, BT; Li, C; Li, D; Li, F; Li, G; Li, H; Li, HW; Li, J; Li, M; Li, P; Li, Q; Li, S; Li, W; Li, X; Li, XY; Li, Y; Li, Z; Lian, Y; Liang, C; Liao, J; Liao, W; Liao, Y; Lin, D; Lin, W; Lin, YL; Lindbäck, J; Lindsay, AP; Ling, J; Linser, PJ; Liu, C; Liu, H; Liu, JJ; Liu, L; Liu, Q; Liu, SF; Liu, X; Liu, Y; Liu, Z; Liu, ZM; Lo Sterzo, C; Lo, ECM; Lobchuk, MM; Lodge, TP; Logotheti, S; Lonial, S; Lopes, G; Lopes, RD; Lopez, J; Lopez, SA; López-Santos, AL; López-Sendón, JL; Loring, Z; Louis, C; Lovita, AND; Lu, DZ; Lu, H; Lu, J; Lu, K; Lu, TT; Lu, Y; Luengo, A; Lum, LG; Luna, JM; Luo, L; Luo, R; Luo, T; Luo, X; Luo, Z; Lv, B; Lymperopoulos, N; Lyras, A; Lyu, Y; M Kannan, A; Ma, H; Ma, M; Ma, Q; Ma, S; Ma, WY; Ma, Y; Maalouf, E; Machado, FA; Maeda, K; Magrans, JO; Maharani, A; Maia, G; Mainwaring, RD; Maji, TK; Majumdar, K; Mannarino, MR; Mansuri, MS; Marinescu, SC; Markatos, G; Marquardt, S; Marraiki, N; Martens, C; Martínez, TJ; Marumo, K; Maruyama, H; Marwani, HM; Marzo, I; Masrati, G; Matamba, P; Mathialagan, S; Matys, J; Mayatra, JM; Mboua, PC; McArthur, T; McCrimmon, RJ; McIntosh, S; McSpadden, S; Medina-Campos, ON; Medvedovsky, AT; Mei, Z; Mekontso-Dessap, A; Menezes, AMB; Meng, J; Meng, P; Meng, Y; Menter, A; Mets, MB; Mets-Halgrimson, R; Metzger, T; Metzler-Nolte, N; Meyer, C; Mi, Y; Michailoviene, V; Mikrogeorgiou, A; Militz, H; Miller Iii, TF; Minarowska, A; Mir, S; Miron, I; Miyake, T; Moayer, F; Modi, S; Moeller, SJ; Mohamad, MN; Mohammed, EHM; Mokhonov, VV; Mondal, A; Moore, J; Moravcova, M; Mordi, IR; Mordi, NA; Mortensen, NP; Moscariello, C; Moser, J; Moynahan, ME; Mu, J; Mu, W; Mudduwa, LKB; Mukherjee, S; Mukhtar, A; Mulkey, DK; Murr, N; Mushtaq, Z; Muthuswamy, N; Mutlu, O; Muto, C; Myroforou, I; Na, KJ; Nabi, M; Nagornov, KO; Nagy, RJ; Naik, A; Nakajima, K; Nam, KT; Nam, YW; Namburath, M; Nammour, S; Namour, A; Namour, M; Nanan, S; Natsume, H; Nave, S; Naveed, A; Nazir, H; Ndubaku, C; Nedospasov, SA; Neradilek, MB; Newcomb, C; Nguépy Keubo, FR; Nguyen, M; Ning, J; Ning, Q; Noguchi, S; Nordahl, SHG; Nordfalk, KF; Norton, L; Noupoue, EM; Nouri, SS; Nowak, JK; Núñez, K; Oakes, K; Odegaard, JI; Ogorodnikova, OL; Ogunsuyi, O; Oh, HK; Oh, HR; Oh, KH; Ohgi, K; Okunade, KS; Oliveira, AG; Olorunfemi, G; Olsen, ML; Olson, BA; Omari, KW; Ondruschka, B; Orfali, R; Orkopoulos, A; Orlowski, RZ; Oser, SM; Oser, TK; Özcan, M; Padilla, V; Paeng, JC; Pajuelo-Lozano, N; Pal, SK; Palmieri, S; Palomeque, E; Pan, W; Panagiotakos, DB; Pandey, M; Pang, D; Pang, Q; Pangarah, CA; Panny, A; Paparella, A; Papirio, S; Papouskova, K; Parang, K; Park, HJ; Park, IK; Park, S; Parker, TL; Parkhomenko, A; Parmon, VN; Parsons, B; Parsons, J; Patel, PR; Patil, S; Patsourakos, NG; Patterson, KC; Pavlidis, P; Pedernera, M; Pedersen, R; Pedraza-Chaverri, J; Pellegrini, M; Peña-Chora, G; Pereira, EDM; Pereira, MADS; Peretz, A; Perez-Padilla, R; Perlman, GY; Perona, R; Petras, C; Phuntsho, S; Picada, JN; Pinder, TA; Piper, LFJ; Pirozzi, F; Pirro, M; Pleckaityte, M; Ploutz-Snyder, LL; Ploutz-Snyder, R; Pogorzelski, A; Poles, L; Postma, AA; Prager, A; Prakash, J; Punn, R; Pützer, BM; Qi, J; Qi, MC; Qi, Y; Qian, J; Qian, Y; Qiang, L; Qiu, J; Qu, Y; Rabiu, KA; Rahighi, S; Rahman, MM; Rahmani, B; Rajkumar, SV; Ramanathan, R; Raras, TYM; Rashi, Y; Rasool, G; Rathore, MG; Ratnawati, R; Ratola, N; Raucci, U; Ray, SK; Razavi, P; Razazi, K; Razek, S; Razi, SS; Reback, M; Reddy, K; Rees, DC; Reginatto, FH; Reich, H; Reis-Filho, JS; Ren, X; Ren, Y; Renner, G; Rey, G; Reymen, B; Riaz, M; Ricci, A; Richardson, PG; Richter, C; Riga, M; Ritchie, C; Rivoal, S; Roberts, W; Robson, ME; Rocha, GZ; Rodrigues, AD; Rogach, AL; Rojas, A; Rosenberg, A; Rosenberg, E; Rosenheck, RA; Roslan, K; Rothenberger, C; Rouschop, KMA; Rubagumya, F; Ryan, CM; Ryder, JW; Saad, MJA; Sacan, O; Sacchi, A; Sahebkar, A; Saini, A; Sainz, B; Sajo, EA; Sakizadeh, J; Saleh, AA; 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| Brachtel, D; Wernze, H | 1 |
| Cai, ZH; O'Shea, GM; Shi, ZQ; Sun, AM | 1 |
| Schmidt, R; Schwedes, U; Siede, WH; Usadel, KH; Vardarli, I; Wdowinski, JM | 1 |
| Fang, YQ; Hou, C | 1 |
| Hanano, M; Iga, T; Itoh, T; Lin, TH; Sawada, Y | 1 |
| Lin, YF; Wu, GL | 1 |
| Hu, DR; Li, MD; Xie, J | 1 |
| Morimoto, Y; Tsuji, T; Ukida, M | 1 |
| Miyata, M | 1 |
| Hardy, MA; Kawai, Y; Price, JB | 1 |
| Eto, T; Kajiyama, G; Nakamura, T; Nakanishi, T; Suemori, S; Yamada, K | 1 |
| Divald, A; Jeney, A; Lapis, K; Schaff, Z; Vajta, G; Zalatnai, A | 1 |
| Fujiwara, K; Kuwata, S; Nishi, T; Nosaka, K; Ogata, I; Ohta, Y; Oka, H | 1 |
| Li, BR; Wu, XM; Zhang, BG; Zhou, Q | 1 |
| Dumont, JM; Maignan, MF; Perrissoud, D | 2 |
| Iijima, I; Matsumoto, M; Matsuoka, Y; Saiga, Y | 1 |
| Wormser, U; Zbinden, G | 1 |
| Guo, SH; Zhang, DF; Zhou, YX | 1 |
| Minami, M; Sato, S; Taguchi, H; Wakayama, Y; Yunoki, H | 1 |
| Adzharov, D; Dimov, S; Naĭdenova, E; Petrova, S; Savov, G | 1 |
| Konz, KH; Tiegs, G; Wendel, A | 1 |
| Barrow, L; Kantarjian, A; Tanner, MS | 1 |
| Aburada, M; Arai, I; Fujii, Y; Funo, S; Hosoya, E; Kase, Y; Maemura, S; Ohkura, Y; Sudo, K; Takeda, S | 1 |
| Brachtel, D; Richter, E | 1 |
| Hikino, H; Kiso, Y; Namiki, T; Nishimura, S; Takeyama, K; Tohkin, M | 1 |
| Blei, AT; Ganger, DR; Traber, PG | 1 |
| Chitranukroh, A; Kawata, S; McIntyre, N; Owen, JS | 1 |
| Kobayashi, A; Sugata, F; Tsubomizu, Y | 1 |
| Baxi, AJ; D'Souza, NB; Kulkarni, AB; Nadkarni, GD | 1 |
| Ernst, P; Marquet, R; ten Berg, RG; van Maldegem-Dronkers, C; Westbroek, DL | 1 |
| Taoka, Y | 1 |
| Nagashima, H; Ukida, M; Usui, H | 1 |
| Bien, E | 1 |
| Andersson, A; Kojima, Y; Korsgren, O; Mellgren, A; Sandler, S; Swenne, I | 1 |
| Siblíková, O; Trcka, V | 1 |
| Baue, AE; Chaudry, IH; Clemens, MG; Hayashi, H; Ohkawa, M | 1 |
| Cooksley, WG; Halliday, JW; Mack, U; Owens, J; Powell, LW | 1 |
| Biou, D; Durand, D; Durand, G; Féger, J; Monnet, D | 1 |
| Hikino, H; Kinouchi, J; Kiso, Y; Sanada, S; Shoji, J | 1 |
| Drenska, D; Klouchek, E; Ovcharov, R; Popov, A | 1 |
| Aburada, M; Harada, M; Maeda, S; Miyamoto, Y; Takeda, S | 1 |
| Hatano, T; Hikino, H; Kiso, Y; Okuda, T; Yoshida, T | 1 |
| Aiyama, R; Hamada, Y; Hikino, H; Itokawa, H; Kato, N; Kiso, Y; Kiuchi, F; Sankawa, U; Shioiri, T | 1 |
| Hikino, H; Husain, A; Kiso, Y; Singh, B; Syamasundar, KV; Thakur, RS | 1 |
| Endoh, F; Fujimoto, S; Kanno, Y; Kawada, S; Kurihara, M; Miyazaki, M; Shimura, T; Sugasawa, H; Takahashi, O; Udagawa, I | 1 |
| Decker, K; Keppler, D; Pausch, J | 2 |
| Shinozuka, H | 1 |
| Bode, JC | 1 |
| Neupert, A; Petzold, H | 1 |
| Petzold, H | 1 |
| Leber, HW; Leinweber, B; Platt, D | 1 |
| Decker, K; Keppler, D | 2 |
| Petzold, H; Titlbach, O | 1 |
| Brunswig, D; Grün, M; Grün, W; Liehr, H; Rasenack, U | 1 |
| Merkel, H; Müller-Berghaus, G; Sattler, EL; von Mahn, I | 1 |
| Albring, M; Rumpelt, HJ | 1 |
| Betzing, H; Lekim, D | 1 |
| Meyer-Burg, J | 1 |
| Rauen, HM; Schriewer, H | 1 |
| Gruen, M; Liehr, H; Thiel, H | 1 |
| Bachmann, W; Bauer, C; Lesch, R; Reutter, W | 2 |
| Alberti, KG; Record, CO; Williamson, DH | 1 |
| Heissmeyer, H; Stein, U | 1 |
| Miertsch, HJ; Róka, L | 1 |
| Alberti, KG; Record, CO | 1 |
| Anukarahanonta, T; Farber, JL; Konishi, Y; Shinozuka, H | 1 |
| Grub, R; Heissmeyer, H; Lesch, R; Reutter, W; Stein, U | 1 |
| Leinweber, B | 1 |
| Lapis, K; Schaff, Z | 1 |
| García-Ruiz, JP; Mayor, F; Moreno, F; Sánchez-Medina, F | 1 |
| Bauer, C; Reutter, W | 1 |
| Rausen, HM; Schriewer, H | 1 |
| Habersang, S; Kozlik, V; Leuschner, F; von Schlichtegroll, A | 1 |
| Antoni, F; Garzó, T; Hrabák, A; Lapis, K; Mészáros, K; Szikla, C; Tompa, A | 1 |
| Triger, DR; Wright, R | 1 |
| Bachman, W; Bauer, C; Lesch, R; Reutter, W | 1 |
| Brachtel, D; Gallenkamp, H; Richter, E | 1 |
| Müller-Berghaus, G; Reuter, C | 1 |
| Reutter, W; Reynolds, RD; Sell, S | 1 |
| Decker, K; Keppler, D; Lesch, R; Reutter, W | 1 |
| Hey, D; Krause, W; Leinweber, B | 1 |
| Brachtel, D; Grün, M; Krauss, H; Liehr, H; Richter, E; Thiel, H | 1 |
| Fujisawa, K; Okabe, K; Tanaka, K | 1 |
| Boelcke, G; Erdmann, WD; Michelssen, A; Poser, W | 1 |
| Hirner, A; Meyer-Burg, J | 1 |
| Leinweber, B; Platt, D | 1 |
16 review(s) available for galactosamine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acrylic Resins; Actinobacillus; Acute Disease; Acute Kidney Injury; Adaptor Proteins, Signal Transducing; Adenosine; Adenosine Triphosphate; Administration, Inhalation; Administration, Oral; Adolescent; Adult; Advance Care Planning; Africa, Northern; Age Factors; Aged; Aged, 80 and over; Air Pollutants; Air Pollution; Air Pollution, Indoor; Albendazole; Aluminum Oxide; Anastomosis, Surgical; Ancylostoma; Ancylostomiasis; Androstadienes; Angiogenesis Inhibitors; Angiotensin II; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antibodies, Bispecific; Antibodies, Viral; Anticoagulants; Antihypertensive Agents; Antinematodal Agents; Antineoplastic Agents; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antiporters; Antiviral Agents; Apoptosis; Aptamers, Nucleotide; Aromatase Inhibitors; Asian People; Astrocytes; Atrial Fibrillation; Auditory Threshold; Aurora Kinase B; Australia; Autophagy; Autophagy-Related Protein 5; Autotrophic Processes; Bacillus cereus; Bacillus thuringiensis; Bacterial Proteins; Beclin-1; Belgium; Benzene; Benzene Derivatives; Benzhydryl Compounds; beta Catenin; beta-Arrestin 2; Biliary Tract Diseases; Biofilms; Biofuels; Biomarkers; Biomarkers, Tumor; Biomass; Biomechanical Phenomena; Bioreactors; Biosensing Techniques; Biosynthetic Pathways; Bismuth; Blood Platelets; Bone and Bones; Bone Regeneration; Bortezomib; Botulinum Toxins, Type A; Brain; Brain Injuries; Brain Ischemia; Brain Neoplasms; Breast Neoplasms; Breath Tests; Bronchodilator Agents; Calcium Phosphates; Cannabis; Carbon Dioxide; Carbon Isotopes; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cardiac Resynchronization Therapy; Cardiac Resynchronization Therapy Devices; Cardiomyopathies; Cardiovascular Diseases; Cariostatic Agents; Case Managers; Case-Control Studies; Catalysis; Cation Transport Proteins; CD8-Positive T-Lymphocytes; Cecropia Plant; Cell Adhesion; Cell Count; Cell Differentiation; Cell Division; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cell Self Renewal; Cell Survival; Cells, Cultured; Cellular Reprogramming; Cellulose; Charcoal; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemokines; Chemoradiotherapy; Chemoreceptor Cells; Child; Child Abuse; Child, Preschool; China; Chlorogenic Acid; Chloroquine; Chromatography, Gas; Chronic Disease; Clinical Competence; Coated Materials, Biocompatible; Cochlea; Cohort Studies; Color; Comorbidity; Computer Simulation; Computer-Aided Design; Contraception; Contraceptive Agents, Female; Contrast Media; COP-Coated Vesicles; Coronavirus Infections; Cost of Illness; Coturnix; COVID-19; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Culex; Curriculum; Cyclic N-Oxides; Cytokines; Cytoplasm; Cytotoxicity, Immunologic; Cytotoxins; Databases, Factual; Deep Learning; Delivery, Obstetric; Denitrification; Dental Caries; Denture, Complete; Dexamethasone; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dielectric Spectroscopy; Diet, High-Fat; Dietary Fiber; Disease Models, Animal; Disease Progression; DNA; DNA Copy Number Variations; DNA, Mitochondrial; Dog Diseases; Dogs; Dopaminergic Neurons; Double-Blind Method; Down-Regulation; Doxorubicin; Drug Carriers; Drug Design; Drug Interactions; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Dry Powder Inhalers; Dust; E2F1 Transcription Factor; Ecosystem; Education, Nursing; Education, Nursing, Baccalaureate; Electric Impedance; Electricity; Electrocardiography; Electrochemical Techniques; Electrochemistry; Electrodes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Endothelial Cells; Environmental Monitoring; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Estrogen Receptor Modulators; Europe; Evoked Potentials, Auditory, Brain Stem; Exosomes; Feasibility Studies; Female; Ferricyanides; Ferrocyanides; Fibrinogen; Finite Element Analysis; Fistula; Fluorescent Dyes; Fluorides, Topical; Fluorodeoxyglucose F18; Fluticasone; Follow-Up Studies; Food Contamination; Food Microbiology; Foods, Specialized; Forensic Medicine; Frail Elderly; France; Free Radicals; Fresh Water; Fungi; Fungicides, Industrial; Galactosamine; Gastrointestinal Neoplasms; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Frequency; Genetic Predisposition to Disease; Genotype; Gingival Hemorrhage; Glioblastoma; Glioma; Glomerular Filtration Rate; Glomerulosclerosis, Focal Segmental; Glucose; Glucose Transport Proteins, Facilitative; Glucosides; Glutamine; Glycolysis; Gold; GPI-Linked Proteins; Gram-Negative Bacteria; Gram-Positive Bacteria; Graphite; Haplotypes; HCT116 Cells; Healthy Volunteers; Hearing Loss; Heart Failure; Hedgehog Proteins; HEK293 Cells; HeLa Cells; Hemodynamics; Hemorrhage; Hepatocytes; Hippo Signaling Pathway; Histone Deacetylases; Homeostasis; Hospital Mortality; Hospitalization; Humans; Hydantoins; Hydrazines; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Hydroxylamines; Hypoglycemic Agents; Immunity, Innate; Immunoglobulin G; Immunohistochemistry; Immunologic Factors; Immunomodulation; Immunophenotyping; Immunotherapy; Incidence; Indazoles; Indonesia; Infant; Infant, Newborn; Infarction, Middle Cerebral Artery; Inflammation; Injections, Intramuscular; Insecticides; Insulin-Like Growth Factor I; Insurance, Health; Intention to Treat Analysis; Interleukin-1 Receptor-Associated Kinases; Interleukin-6; Intrauterine Devices; Intrauterine Devices, Copper; Iron; Ischemia; Jordan; Keratinocytes; Kidney; Kidney Diseases; Kir5.1 Channel; Klebsiella Infections; Klebsiella pneumoniae; Lab-On-A-Chip Devices; Laparoscopy; Lasers; Lasers, Semiconductor; Lenalidomide; Leptin; Lethal Dose 50; Levonorgestrel; Limit of Detection; Lipid Metabolism; Lipid Metabolism Disorders; Lipogenesis; Lipopolysaccharides; Liquid Biopsy; Liver; Liver Abscess, Pyogenic; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Longevity; Lung Neoplasms; Luteolin; Lymph Nodes; Lymphocyte Activation; Macaca fascicularis; Macrophages; Mad2 Proteins; Magnetic Resonance Imaging; Male; Mammary Glands, Human; Manganese; Manganese Compounds; MAP Kinase Signaling System; Materials Testing; Maternal Health Services; MCF-7 Cells; Medicaid; Medicine, Chinese Traditional; Melanoma; Membrane Proteins; Mental Health; Mercury; Metal Nanoparticles; Metals, Heavy; Metformin; Methionine Adenosyltransferase; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Mice, Nude; Microalgae; Microbial Sensitivity Tests; Microglia; MicroRNAs; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Middle Aged; Mitochondria; Mitochondrial Proteins; Mitral Valve; Mitral Valve Insufficiency; Models, Anatomic; Molecular Structure; Molybdenum; Monocarboxylic Acid Transporters; Moths; MPTP Poisoning; Multigene Family; Multiparametric Magnetic Resonance Imaging; Multiple Myeloma; Muscle, Skeletal; Mutagens; Mutation; Myeloid Cells; Nanocomposites; Nanofibers; Nanomedicine; Nanoparticles; Nanowires; Neoadjuvant Therapy; Neomycin; Neoplasm Grading; Neoplasm Recurrence, Local; Neoplasms; Neoplastic Stem Cells; Neostriatum; Neovascularization, Pathologic; Netherlands; Neuromuscular Agents; Neurons; NF-E2-Related Factor 2; NF-kappa B; Nickel; Nitrogen Oxides; Non-alcoholic Fatty Liver Disease; Nucleosides; Nucleotidyltransferases; Nutritional Status; Obesity, Morbid; Ofloxacin; Oils, Volatile; Oligopeptides; Oncogene Protein v-akt; Optical Imaging; Organic Cation Transport Proteins; Organophosphonates; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Osteoblasts; Osteogenesis; Oxidation-Reduction; Oxidative Stress; Oxides; Oxygen Isotopes; Pancreas; Pancreaticoduodenectomy; Pandemics; Particle Size; Particulate Matter; Patient Acceptance of Health Care; Patient Compliance; PC-3 Cells; Peptide Fragments; Peptides; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Periodontitis; Peroxides; Peru; Pest Control, Biological; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Phylogeny; Pilot Projects; Piperidines; Plant Bark; Plant Extracts; Plant Leaves; Plasmids; Platelet Function Tests; Pneumonia, Viral; Podocytes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Polyethylene Terephthalates; Polymers; Polymorphism, Single Nucleotide; Porosity; Portugal; Positron-Emission Tomography; Postoperative Complications; Postural Balance; Potassium Channels, Inwardly Rectifying; Povidone; Powders; Precancerous Conditions; Precision Medicine; Predictive Value of Tests; Pregnancy; Prenatal Care; Prognosis; Promoter Regions, Genetic; Prospective Studies; Prostatectomy; Prostatic Neoplasms; Proteasome Inhibitors; Protective Agents; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Psychiatric Nursing; PTEN Phosphohydrolase; Pulmonary Embolism; Pyrimethamine; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reactive Oxygen Species; Receptor, ErbB-2; Receptor, IGF Type 1; Receptors, Estrogen; Receptors, G-Protein-Coupled; Recombinational DNA Repair; Recovery of Function; Regional Blood Flow; Renal Dialysis; Renin; Renin-Angiotensin System; Reperfusion Injury; Reproducibility of Results; Republic of Korea; Respiratory Distress Syndrome; Retrospective Studies; Rhodamines; Risk Assessment; Risk Factors; RNA, Long Noncoding; RNA, Messenger; Running; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salinity; Salmeterol Xinafoate; Sarcoma; Seasons; Shoulder Injuries; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Sirtuins; Skull Fractures; Social Determinants of Health; Sodium; Sodium Fluoride; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Glucose Transporter 2 Inhibitors; Soil; Soil Pollutants; Spain; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Staphylococcal Protein A; Staphylococcus aureus; Stem Cells; Stereoisomerism; Stomach Neoplasms; Streptomyces; Strontium; Structure-Activity Relationship; Students, Nursing; Substance-Related Disorders; Succinic Acid; Sulfur; Surface Properties; Survival Rate; Survivin; Symporters; T-Lymphocytes; Temozolomide; Tensile Strength; Thiazoles; Thiobacillus; Thiohydantoins; Thiourea; Thrombectomy; Time Factors; Titanium; Tobacco Mosaic Virus; Tobacco Use Disorder; Toll-Like Receptor 4; Toluene; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Toxicity Tests, Acute; Toxicity Tests, Subacute; Transcriptional Activation; Treatment Outcome; Troponin I; Tumor Cells, Cultured; Tumor Escape; Tumor Hypoxia; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Tyrosine; Ubiquitin-Protein Ligases; Ubiquitination; Ultrasonic Waves; United Kingdom; United States; United States Department of Veterans Affairs; Up-Regulation; Urea; Uric Acid; Urinary Bladder Neoplasms; Urinary Bladder, Neurogenic; Urine; Urodynamics; User-Computer Interface; Vemurafenib; Verbenaceae; Veterans; Veterans Health; Viral Load; Virtual Reality; Vitiligo; Water Pollutants, Chemical; Wildfires; Wnt Signaling Pathway; Wound Healing; X-Ray Diffraction; Xenograft Model Antitumor Assays; Xylenes; Young Adult; Zinc; Zinc Oxide; Zinc Sulfate; Zoonoses | 2021 |
Experimental models of hepatotoxicity related to acute liver failure.
Topics: Acetaminophen; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Concanavalin A; Disease Models, Animal; Fas Ligand Protein; Galactosamine; Humans; Liver Failure, Acute | 2016 |
[Search for TNF-alpha sensitivity degradation principles from medicinal foods-hepatoprotective amide constituents from Thai natural medicine Piper chaba].
Topics: Alkaloids; Amides; Animals; Benzodioxoles; Cells, Cultured; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Galactosamine; Hepatocytes; Lipopolysaccharides; Mice; Piper; Piperidines; Polyunsaturated Alkamides; Structure-Activity Relationship; Tumor Necrosis Factor-alpha | 2010 |
[Endotoxins of Gram-negative bacteria in liver diseases].
Topics: Animals; Antitoxins; Bacterial Infections; Chemical and Drug Induced Liver Injury; Endotoxins; Galactosamine; Gram-Negative Bacteria; Hepatitis A; Humans; Intestinal Absorption; Kupffer Cells; Limulus Test; Liver Cirrhosis; Rats; Toxemia | 1980 |
Calcium and the mechanisms of liver necrosis.
Topics: Animals; Calcium; Carbon Tetrachloride; Cell Membrane; Chemical and Drug Induced Liver Injury; Galactosamine; In Vitro Techniques; Liver; Liver Diseases; Necrosis; Phalloidine; Rats | 1982 |
Immunotoxicology of host-response-mediated experimental liver injury.
Topics: Animals; Autoimmune Diseases; Chemical and Drug Induced Liver Injury; Concanavalin A; Disease Models, Animal; Galactosamine; Humans; Infections; Lipopolysaccharides; Liver Diseases; Tumor Necrosis Factor-alpha | 1994 |
[Inhibitory effect of green tea infusion of hepatotoxicity].
Topics: Animals; Carbon Tetrachloride; Catechin; Chemical and Drug Induced Liver Injury; Flavonoids; Galactosamine; Humans; Male; Mice; Nitroparaffins; Pentachlorophenol; Propane; Rats; Tea | 1998 |
[Role of endotoxins in renal changes during hepatopathies].
Topics: Acute Kidney Injury; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Diuresis; Endotoxins; Galactosamine; Guinea Pigs; Hemodynamics; Hepatitis; Humans; Kidney Diseases; Liver Cirrhosis; Liver Diseases; Osmolar Concentration; Rats; Water-Electrolyte Balance | 1978 |
[On the molecular mechanism of action of (+)-cyanidanol-3 (author's transl)].
Topics: Animals; Benzopyrans; Catechin; Chemical and Drug Induced Liver Injury; Galactosamine; Lipid Peroxides; Liver; Liver Diseases; Membranes; Phalloidine | 1979 |
Mechanism and clinical relevance of elevated levels of circulating asialoglycoproteins.
Topics: Acute Disease; Animals; Asialoglycoproteins; Biomarkers; Chemical and Drug Induced Liver Injury; Chronic Disease; Disease Models, Animal; Galactosamine; Hepatitis; Humans; Liver Diseases; Liver Neoplasms, Experimental; Liver Regeneration | 1991 |
[Current status of the study of mechanisms of liver injury caused by some commonly used hepatotoxic agents].
Topics: Acetaminophen; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Galactosamine | 1990 |
[Animal disease models--injury, death and various changes of liver cells].
Topics: Animals; Cell Survival; Chemical and Drug Induced Liver Injury; Collagen; Cricetinae; Disease Models, Animal; Ethionine; Fatty Liver; Galactosamine; Guinea Pigs; Liver; Lysosomes; Mice; Mitochondria, Liver; Protein Biosynthesis; Rabbits; Rats | 1985 |
[Possibilities of liver damage by foreign substances].
Topics: Aminopyrine; Animals; Antimetabolites; Carcinogens; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Cytochrome P-450 Enzyme System; Galactosamine; Halothane; Humans; Isoniazid; Membranes; Methyldopa; Nucleic Acids; Oxidation-Reduction; Pharmaceutical Preparations; Prostaglandin-Endoperoxide Synthases; Protein Biosynthesis | 1985 |
The regulation of pyrimidine nucleotide level and its role in experimental hepatitis.
Topics: Animals; Carboxy-Lyases; Chemical and Drug Induced Liver Injury; Cytosine Nucleotides; Galactosamine; Galactose; Glucose-6-Phosphatase; Guanosine; Hexosamines; Hexosephosphates; Liver; Nucleotidyltransferases; Pentosyltransferases; Phosphotransferases; Pyrimidine Nucleotides; Rats; Ribonucleotides; RNA-Directed DNA Polymerase; Uridine Diphosphate Sugars | 1973 |
Galactosamine hepatitis: key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death.
Topics: Animals; Blood Coagulation Factors; Carbohydrates; Carcinoma, Hepatocellular; Cell Survival; Chemical and Drug Induced Liver Injury; Deoxy Sugars; Disease Models, Animal; Galactosamine; Galactose; Glucosamine; Hyperbilirubinemia; Liver Neoplasms; Macromolecular Substances; Protein Biosynthesis; Pyrimidine Nucleotides; RNA; Time Factors; Uracil Nucleotides; Uridine; Uridine Diphosphate Sugars | 1974 |
Galactosamine induced liver injury.
Topics: Amino Acids; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Fishes; Galactosamine; Gluconeogenesis; Guinea Pigs; Haplorhini; Humans; Liver; Proteins; Rabbits; Rats; RNA; Uracil Nucleotides; Uridine | 1972 |
2 trial(s) available for galactosamine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acrylic Resins; Actinobacillus; Acute Disease; Acute Kidney Injury; Adaptor Proteins, Signal Transducing; Adenosine; Adenosine Triphosphate; Administration, Inhalation; Administration, Oral; Adolescent; Adult; Advance Care Planning; Africa, Northern; Age Factors; Aged; Aged, 80 and over; Air Pollutants; Air Pollution; Air Pollution, Indoor; Albendazole; Aluminum Oxide; Anastomosis, Surgical; Ancylostoma; Ancylostomiasis; Androstadienes; Angiogenesis Inhibitors; Angiotensin II; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antibodies, Bispecific; Antibodies, Viral; Anticoagulants; Antihypertensive Agents; Antinematodal Agents; Antineoplastic Agents; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antiporters; Antiviral Agents; Apoptosis; Aptamers, Nucleotide; Aromatase Inhibitors; Asian People; Astrocytes; Atrial Fibrillation; Auditory Threshold; Aurora Kinase B; Australia; Autophagy; Autophagy-Related Protein 5; Autotrophic Processes; Bacillus cereus; Bacillus thuringiensis; Bacterial Proteins; Beclin-1; Belgium; Benzene; Benzene Derivatives; Benzhydryl Compounds; beta Catenin; beta-Arrestin 2; Biliary Tract Diseases; Biofilms; Biofuels; Biomarkers; Biomarkers, Tumor; Biomass; Biomechanical Phenomena; Bioreactors; Biosensing Techniques; Biosynthetic Pathways; Bismuth; Blood Platelets; Bone and Bones; Bone Regeneration; Bortezomib; Botulinum Toxins, Type A; Brain; Brain Injuries; Brain Ischemia; Brain Neoplasms; Breast Neoplasms; Breath Tests; Bronchodilator Agents; Calcium Phosphates; Cannabis; Carbon Dioxide; Carbon Isotopes; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cardiac Resynchronization Therapy; Cardiac Resynchronization Therapy Devices; Cardiomyopathies; Cardiovascular Diseases; Cariostatic Agents; Case Managers; Case-Control Studies; Catalysis; Cation Transport Proteins; CD8-Positive T-Lymphocytes; Cecropia Plant; Cell Adhesion; Cell Count; Cell Differentiation; Cell Division; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cell Self Renewal; Cell Survival; Cells, Cultured; Cellular Reprogramming; Cellulose; Charcoal; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemokines; Chemoradiotherapy; Chemoreceptor Cells; Child; Child Abuse; Child, Preschool; China; Chlorogenic Acid; Chloroquine; Chromatography, Gas; Chronic Disease; Clinical Competence; Coated Materials, Biocompatible; Cochlea; Cohort Studies; Color; Comorbidity; Computer Simulation; Computer-Aided Design; Contraception; Contraceptive Agents, Female; Contrast Media; COP-Coated Vesicles; Coronavirus Infections; Cost of Illness; Coturnix; COVID-19; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Culex; Curriculum; Cyclic N-Oxides; Cytokines; Cytoplasm; Cytotoxicity, Immunologic; Cytotoxins; Databases, Factual; Deep Learning; Delivery, Obstetric; Denitrification; Dental Caries; Denture, Complete; Dexamethasone; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dielectric Spectroscopy; Diet, High-Fat; Dietary Fiber; Disease Models, Animal; Disease Progression; DNA; DNA Copy Number Variations; DNA, Mitochondrial; Dog Diseases; Dogs; Dopaminergic Neurons; Double-Blind Method; Down-Regulation; Doxorubicin; Drug Carriers; Drug Design; Drug Interactions; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Dry Powder Inhalers; Dust; E2F1 Transcription Factor; Ecosystem; Education, Nursing; Education, Nursing, Baccalaureate; Electric Impedance; Electricity; Electrocardiography; Electrochemical Techniques; Electrochemistry; Electrodes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Endothelial Cells; Environmental Monitoring; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; 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Skull Fractures; Social Determinants of Health; Sodium; Sodium Fluoride; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Glucose Transporter 2 Inhibitors; Soil; Soil Pollutants; Spain; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Staphylococcal Protein A; Staphylococcus aureus; Stem Cells; Stereoisomerism; Stomach Neoplasms; Streptomyces; Strontium; Structure-Activity Relationship; Students, Nursing; Substance-Related Disorders; Succinic Acid; Sulfur; Surface Properties; Survival Rate; Survivin; Symporters; T-Lymphocytes; Temozolomide; Tensile Strength; Thiazoles; Thiobacillus; Thiohydantoins; Thiourea; Thrombectomy; Time Factors; Titanium; Tobacco Mosaic Virus; Tobacco Use Disorder; Toll-Like Receptor 4; Toluene; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Toxicity Tests, Acute; Toxicity Tests, Subacute; Transcriptional Activation; Treatment Outcome; Troponin I; Tumor Cells, Cultured; Tumor Escape; Tumor Hypoxia; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Tyrosine; Ubiquitin-Protein Ligases; Ubiquitination; Ultrasonic Waves; United Kingdom; United States; United States Department of Veterans Affairs; Up-Regulation; Urea; Uric Acid; Urinary Bladder Neoplasms; Urinary Bladder, Neurogenic; Urine; Urodynamics; User-Computer Interface; Vemurafenib; Verbenaceae; Veterans; Veterans Health; Viral Load; Virtual Reality; Vitiligo; Water Pollutants, Chemical; Wildfires; Wnt Signaling Pathway; Wound Healing; X-Ray Diffraction; Xenograft Model Antitumor Assays; Xylenes; Young Adult; Zinc; Zinc Oxide; Zinc Sulfate; Zoonoses | 2021 |
Efficacy of MK615 for the treatment of patients with liver disorders.
Topics: Adult; Aged; Aged, 80 and over; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Fatty Liver; Female; Galactosamine; Hepatitis C; Hepatitis, Autoimmune; Humans; Liver; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Plant Extracts; Prunus; Rats; Rats, Wistar; Treatment Outcome | 2012 |
823 other study(ies) available for galactosamine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
The mitochondria-targeting antioxidant MitoQ alleviated lipopolysaccharide/ d-galactosamine-induced acute liver injury in mice.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Galactosamine; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Mitochondria, Liver; Organophosphorus Compounds; Ubiquinone | 2021 |
Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Cells, Cultured; Chalcones; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Inflammasomes; Inflammation Mediators; Lipopolysaccharides; Liver; Liver Failure, Acute; Male; Mice, Inbred C57BL; NF-E2-Related Factor 2; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Signal Transduction | 2021 |
Remimazolam reduces sepsis-associated acute liver injury by activation of peripheral benzodiazepine receptors and p38 inhibition of macrophages.
Topics: Animals; Benzodiazepines; Chemical and Drug Induced Liver Injury; Cytokines; Galactosamine; Inflammation; Lipopolysaccharides; Liver; Macrophages; Male; Mice; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Rats; RAW 264.7 Cells; Receptors, GABA-A; Sepsis | 2021 |
Effect of oridonin on oxylipins in the livers of mice with acute liver injury induced by D-galactosamine and lipopolysaccharide.
Topics: Animals; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Arachidonate 5-Lipoxygenase; Chemical and Drug Induced Liver Injury; Cyclooxygenase 1; Cyclooxygenase 2; Diterpenes, Kaurane; Galactosamine; Lipopolysaccharides; Liver; Male; Membrane Proteins; Mice, Inbred C57BL; Organic Anion Transporters; Oxylipins; Protective Agents | 2022 |
Maresin 1 protects against lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting macrophage pyroptosis and inflammatory response.
Topics: Animals; Cell Line; Chemical and Drug Induced Liver Injury; Cytokines; Docosahexaenoic Acids; Galactosamine; Heme Oxygenase-1; Inflammasomes; Lipopolysaccharides; Liver; Macrophages; Mice; NF-E2-Related Factor 2; NF-kappa B; Protective Agents; Pyroptosis; RAW 264.7 Cells; Reactive Oxygen Species | 2022 |
[Dexmedetomidine alleviates LPS/D-Gal-induced acute liver injury via up-regulation of LC3-II expression in mice].
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Dexmedetomidine; Galactosamine; Interleukin-6; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred BALB C; Microtubule-Associated Proteins; Tumor Necrosis Factor-alpha; Up-Regulation | 2021 |
Multiple Intestinal Bacteria Associated with the Better Protective Effect of
Topics: Animals; Bifidobacterium pseudocatenulatum; Chemical and Drug Induced Liver Injury; Galactosamine; Gastrointestinal Microbiome; Humans; Lipopolysaccharides; Liver; Rats | 2022 |
Preclinical validation of silibinin/albumin nanoparticles as an applicable system against acute liver injury.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Galactosamine; Lipopolysaccharides; Liver; Mice; Nanoparticles; Serum Albumin, Bovine; Silybin | 2022 |
Hepatoprotective Effects of Albumin-Encapsulated Nanoparticles of a Curcumin Derivative COP-22 against Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Injury in Mice.
Topics: Albumins; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Curcumin; Galactosamine; Lipopolysaccharides; Liver; Liver Failure, Acute; Mice; Nanoparticles; NF-kappa B | 2022 |
Deer antler based active ingredients have protective effects on LPS/d-GalN-induced acute liver injury in mice through MAPK and NF-κB signalling pathways.
Topics: Animals; Anti-Inflammatory Agents; Antlers; Chemical and Drug Induced Liver Injury; Deer; Galactosamine; Lipopolysaccharides; Mice; NF-kappa B; NF-KappaB Inhibitor alpha | 2022 |
Oxidative brain and cerebellum injury induced by d-galactosamine: Protective effect of S-methyl methionine sulfonium chloride.
Topics: Acetylcholinesterase; Animals; Antioxidants; Brain; Carbonic Anhydrases; Catalase; Cerebellum; Chemical and Drug Induced Liver Injury; Chlorides; Female; Galactosamine; Glutathione; Lactate Dehydrogenases; Methionine; Oxidants; Oxidative Stress; Peroxidase; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sulfonium Compounds; Superoxide Dismutase; Vitamin U; Xanthine Oxidase | 2022 |
Oxyberberine, a novel HO-1 agonist, effectively ameliorates oxidative stress and inflammatory response in LPS/D-GalN induced acute liver injury mice via coactivating erythrocyte metabolism and Nrf2 signaling pathway.
Topics: Animals; Chemical and Drug Induced Liver Injury; Erythrocytes; Galactosamine; Heme Oxygenase-1; Inflammation; Kelch-Like ECH-Associated Protein 1; Lipopolysaccharides; Liver; Mice; NF-E2-Related Factor 2; Oxidative Stress; Signal Transduction | 2022 |
The protective effects of myricetin against acute liver failure via inhibiting inflammation and regulating oxidative stress via Nrf2 signaling.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Inflammation; Lipopolysaccharides; Liver; Liver Failure, Acute; Mice; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress | 2023 |
Orientin Attenuated d-GalN/LPS-Induced Liver Injury through the Inhibition of Oxidative Stress via Nrf2/Keap1 Pathway.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Flavonoids; Galactosamine; Glucosides; Hydrogen Peroxide; Kelch-Like ECH-Associated Protein 1; Lipopolysaccharides; Liver; Mice; NF-E2-Related Factor 2; Oxidative Stress; Phosphatidylinositol 3-Kinases | 2022 |
Hepatocyte-Conditional Knockout of Phosphatidylethanolamine Binding Protein 4 Aggravated LPS/D-GalN-Induced Acute Liver Injury
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Hepatocytes; Humans; Inflammation; Lipopolysaccharides; Liver; Mice; Mice, Knockout; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphatidylethanolamine Binding Protein; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2022 |
Hepatoprotective effects of different mulberry leaf extracts against acute liver injury in rats by alleviating oxidative stress and inflammatory response.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Lipopolysaccharides; Liver; Morus; NF-E2-Related Factor 2; Oxidative Stress; Plant Extracts; Rats | 2022 |
Evaluation of Hepatoprotective Effects of Piperlongumine Derivative PL 1-3-Loaded Albumin Nanoparticles on Lipopolysaccharide/d-Galactosamine-Induced Acute Liver Injury in Mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Inflammation; Lipopolysaccharides; Liver; Mice; Nanoparticles; NF-E2-Related Factor 2; NF-kappa B; Serum Albumin, Bovine | 2022 |
Lysine specific demethylase 1 inhibitor alleviated lipopolysaccharide/D-galactosamine-induced acute liver injury.
Topics: Alanine Transaminase; Amines; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cytokines; Flavin-Adenine Dinucleotide; Galactosamine; Histone Demethylases; Histones; Interleukin-6; Lipopolysaccharides; Liver; Lysine; Mice; NF-E2-Related Factor 2; NF-kappa B; Oxidoreductases; Tumor Necrosis Factor-alpha | 2022 |
Dynamics of Acute Liver Injury in Experimental Models of Hepatotoxicity in the Context of Their Implementation in Preclinical Studies on Stem Cell Therapy.
Topics: Animals; Cell- and Tissue-Based Therapy; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Lipopolysaccharides; Liver; Liver Failure, Acute; Mice; Necrosis; Rats | 2022 |
Combination of Phycocyanin, Zinc, and Selenium Improves Survival Rate and Inflammation in the Lipopolysaccharide-Galactosamine Mouse Model.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cytokines; Galactosamine; Inflammation; Lipopolysaccharides; Liver; Mice; Phycocyanin; Selenium; Survival Rate; Tumor Necrosis Factor-alpha; Zinc | 2023 |
Protective Effects of p-CA Against Acute Liver Damage Induced by LPS/D-GalN in Wistar Albino Rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Cholesterol, LDL; Coumaric Acids; Galactosamine; Glutathione; Interleukin-6; Lipopolysaccharides; Liver; Malondialdehyde; Rats; Rats, Wistar; Saline Solution; Silymarin; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2022 |
Bromelain ameliorates D-galactosamine-induced acute liver injury: role of SIRT1/LKB1/AMPK, GSK3β/Nrf2 and NF-κB p65/TNF-α/caspase-8, -9 signalling pathways.
Topics: AMP-Activated Protein Kinases; Animals; Bromelains; Caspase 8; Chemical and Drug Induced Liver Injury; Galactosamine; Glycogen Synthase Kinase 3 beta; Liver; NF-E2-Related Factor 2; NF-kappa B; Rats; Silymarin; Sirtuin 1; Tumor Necrosis Factor-alpha | 2022 |
The effects of rhein on D-GalN/LPS-induced acute liver injury in mice: Results from gut microbiome-metabolomics and host transcriptome analysis.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Gastrointestinal Microbiome; Gene Expression Profiling; Lipopolysaccharides; Mice; RNA, Ribosomal, 16S | 2022 |
Janus kinase inhibitor Tofacitinib alleviated acute hepatitis induced by lipopolysaccharide/D-galactosamine in mice.
Topics: Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cytokines; Galactosamine; Hepatitis; Inflammation; Janus Kinase Inhibitors; Janus Kinases; Lipopolysaccharides; Liver; Mice; Tumor Necrosis Factor-alpha | 2023 |
Pharmacokinetic-pharmacodynamic (PK/PD) modeling to study the hepatoprotective effect of Perilla Folium on the acute hepatic injury rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Galactosamine; Lipopolysaccharides; Liver; Rats; Tandem Mass Spectrometry | 2023 |
Preventive Effect of 6-shogaol on D-galactosamine Induced Hepatotoxicity Through NF-?B/MAPK Signaling Pathway in Rats.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Galactosamine; Lipopolysaccharides; Liver; Rats; Rats, Wistar; Signal Transduction | 2023 |
β-Carotene Protects Mice against Lipopolysaccharide and D-Galactosamine Induced Acute Liver Injury via Regulation of NF-κB, MAPK, and Nrf2 Signaling.
Topics: Animals; Antioxidants; beta Carotene; Chemical and Drug Induced Liver Injury; Galactosamine; Lipopolysaccharides; Liver; Mice; NF-E2-Related Factor 2; NF-kappa B; Tumor Necrosis Factor-alpha | 2023 |
BRISC is required for optimal activation of NF-κB in Kupffer cells induced by LPS and contributes to acute liver injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Galactosamine; Inflammation; Kupffer Cells; Lipopolysaccharides; Liver; Mice; NF-kappa B; Tumor Necrosis Factor-alpha | 2023 |
Engeletin inhibits Lipopolysaccharide/d-galactosamine-induced liver injury in mice through activating PPAR-γ.
Topics: Animals; Chemical and Drug Induced Liver Injury; Flavonols; Galactosamine; Glycosides; Interleukin-1beta; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred BALB C; NF-kappa B; PPAR gamma; Signal Transduction; Tumor Necrosis Factor-alpha | 2019 |
Succinate dehydrogenase inhibitor dimethyl malonate alleviates LPS/d-galactosamine-induced acute hepatic damage in mice.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cells, Cultured; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Hepatocytes; Humans; Inflammation Mediators; Lipopolysaccharides; Liver; Male; Malonates; Mice; Mice, Inbred BALB C; Succinate Dehydrogenase | 2019 |
LC-MS/MS Method for Simultaneous Determination of Linarin and Its Metabolites in Rat Plasma and Liver Tissue Samples: Application to Pharmacokinetic and Liver Tissue Distribution Study After Oral Administration of Linarin.
Topics: Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Disease Models, Animal; Galactosamine; Glycosides; Liver; Male; Plasma; Rats; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tissue Distribution | 2019 |
[Effects of saikosaponin b_2 on inflammation and energy metabolism in mice with acute liver injury induced by LPS/GalN].
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytokines; Energy Metabolism; Galactosamine; Inflammation; Lipopolysaccharides; Liver; Mice; NF-kappa B; Oleanolic Acid; Random Allocation; Saponins; Sirtuins | 2019 |
Lactobacillus helveticus R0052 alleviates liver injury by modulating gut microbiome and metabolome in D-galactosamine-treated rats.
Topics: Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Cytokines; Feces; Galactosamine; Gastrointestinal Microbiome; Intestines; Lactobacillus helveticus; Liver; Male; Metabolome; Probiotics; Rats; Rats, Sprague-Dawley | 2019 |
Propofol attenuates inflammatory response and apoptosis to protect d-galactosamine/lipopolysaccharide induced acute liver injury via regulating TLR4/NF-κB/NLRP3 pathway.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Chemical and Drug Induced Liver Injury; Cytokines; Disease Models, Animal; Galactosamine; Inflammasomes; Inflammation; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Propofol; Protective Agents; Signal Transduction; Toll-Like Receptor 4 | 2019 |
Protective effect of apigenin on d-galactosamine/LPS-induced hepatocellular injury by increment of Nrf-2 nucleus translocation.
Topics: Active Transport, Cell Nucleus; Anilides; Animals; Apigenin; Cell Nucleus; Cells, Cultured; Chemical and Drug Induced Liver Injury; Galactosamine; Heptanoic Acids; Lipopolysaccharides; NF-E2-Related Factor 2; NF-kappa B; PPAR gamma; Rats | 2020 |
Depressive-like behaviors are induced by chronic liver injury in male and female mice.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Depression; Female; Galactosamine; Hindlimb Suspension; Hippocampus; Liver; Male; Mice; Swimming; Thioacetamide | 2020 |
Chicoric acid ameliorate inflammation and oxidative stress in Lipopolysaccharide and d-galactosamine induced acute liver injury.
Topics: Alanine Transaminase; AMP-Activated Protein Kinase Kinases; Animals; Aspartate Aminotransferases; Autophagy; Caffeic Acids; Chemical and Drug Induced Liver Injury; Galactosamine; Gene Expression Regulation; Hep G2 Cells; Humans; Inflammation; Lipopolysaccharides; Liver; Mice; Mitogen-Activated Protein Kinase Kinases; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Protein Kinases; Succinates | 2020 |
Bifidobacterium longum R0175 Protects Rats against d-Galactosamine-Induced Acute Liver Failure.
Topics: Animals; Aspartate Aminotransferases; Bifidobacterium longum; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Chemokines; Cytokines; Dysbiosis; Galactosamine; Gastrointestinal Microbiome; Male; Probiotics; Rats; Rats, Sprague-Dawley | 2020 |
Protective Role of Shiitake Mushroom-Derived Exosome-Like Nanoparticles in D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Exosomes; Galactosamine; Lipopolysaccharides; Liver; Liver Failure, Acute; Macrophages; Mice; Nanoparticles; NLR Family, Pyrin Domain-Containing 3 Protein; Plant Extracts; Protective Agents; Shiitake Mushrooms | 2020 |
Therapeutic benefits of apocynin in mice with lipopolysaccharide/D-galactosamine-induced acute liver injury via suppression of the late stage pro-apoptotic AMPK/JNK pathway.
Topics: Acetophenones; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Biopsy; Caspases; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Enzyme Inhibitors; Galactosamine; Hepatocytes; Immunohistochemistry; Lipopolysaccharides; MAP Kinase Signaling System; Mice; Oxidative Stress; Phosphorylation; Reactive Oxygen Species | 2020 |
Sedum sarmentosum Bunge extract ameliorates lipopolysaccharide- and D-galactosamine-induced acute liver injury by attenuating the hedgehog signaling pathway via regulation of miR-124 expression.
Topics: Animals; Chemical and Drug Induced Liver Injury; China; Disease Models, Animal; Galactosamine; Hedgehog Proteins; Lipopolysaccharides; Mice; MicroRNAs; Plant Extracts; Sedum | 2020 |
Panaxynol from
Topics: Animals; Apiaceae; Chemical and Drug Induced Liver Injury; Diynes; Dose-Response Relationship, Drug; Fatty Alcohols; Galactosamine; Gene Expression Regulation; Heme Oxygenase-1; Inflammation; Lipopolysaccharides; Male; Membrane Proteins; Mice; Molecular Structure; NF-E2-Related Factor 2; NF-kappa B; NF-KappaB Inhibitor alpha; Signal Transduction; Specific Pathogen-Free Organisms | 2020 |
Vital members in the gut microbiotas altered by two probiotic Bifidobacterium strains against liver damage in rats.
Topics: Animals; Bacteria; Bifidobacterium; Chemical and Drug Induced Liver Injury; DNA, Bacterial; Galactosamine; Gastrointestinal Microbiome; High-Throughput Nucleotide Sequencing; Phylogeny; Probiotics; Rats; Sequence Analysis, DNA | 2020 |
Asiatic acid ameliorates acute hepatic injury by reducing endoplasmic reticulum stress and triggering hepatocyte autophagy.
Topics: Animals; Apoptosis; Autophagy; Autophagy-Related Proteins; Cell Cycle Checkpoints; Cell Line; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Endoplasmic Reticulum Stress; Galactosamine; Hepatocytes; Humans; Lipopolysaccharides; Liver; Male; Mice, Inbred C57BL; Pentacyclic Triterpenes | 2020 |
Combination of monoammonium glycyrrhizinate and cysteine hydrochloride ameliorated lipopolysaccharide/galactosamine-induced acute liver injury through Nrf2/ARE pathway.
Topics: Animals; Antioxidant Response Elements; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cysteine; Cytokines; Drug Combinations; Galactosamine; Glutathione; Glycyrrhizic Acid; Heme Oxygenase-1; Hepatocytes; Lipopolysaccharides; Liver; Male; Malondialdehyde; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2; Peroxidase; Signal Transduction; Superoxide Dismutase | 2020 |
Biological Effects of Korean Red Ginseng Polysaccharides in Aged Rat Using Global Proteomic Approach.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Ginsenosides; Lung Neoplasms; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Panax; Phytotherapy; Plant Extracts; Polysaccharides; Protective Agents; Proteome; Rats; Rats, Sprague-Dawley; Spleen | 2020 |
Sleep deprivation aggravated lipopolysaccharide/D-galactosamine-induced acute liver injury by suppressing melatonin production.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Caspases; Chemical and Drug Induced Liver Injury; Galactosamine; Lipopolysaccharides; Liver; Male; Melatonin; Mice, Inbred BALB C; Sleep Deprivation; Tumor Necrosis Factor-alpha | 2020 |
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; Cytokines; Endotoxins; Fermentation; Galactosamine; Inflammation; Lipid Peroxidation; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Necrosis; Nitric Oxide; Nitric Oxide Synthase Type II; Phytotherapy; Plant Extracts; Platycodon; RAW 264.7 Cells; Signal Transduction | 2020 |
Hesperetin, a SIRT1 activator, inhibits hepatic inflammation via AMPK/CREB pathway.
Topics: Acetylation; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Enzyme Activation; Galactosamine; HEK293 Cells; Hesperidin; Humans; Liver; Macrophages; Male; Mice; Mice, Inbred BALB C; Protein Processing, Post-Translational; RAW 264.7 Cells; Signal Transduction; Sirtuin 1; Transcription Factor RelA | 2020 |
Suppression of inflammatory cascades via novel cinnamic acid nanoparticles in acute hepatitis rat model.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Cinnamates; Galactosamine; Gamma Rays; Hepatitis; Liver; Male; Nanoparticles; Oxidative Stress; Proteins; Rats, Sprague-Dawley; Signal Transduction | 2020 |
Inhibition of Bruton tyrosine kinase by acalabrutinib dampens lipopolysaccharide/galactosamine-induced hepatic damage.
Topics: Agammaglobulinaemia Tyrosine Kinase; Animals; Apoptosis; Benzamides; Chemical and Drug Induced Liver Injury; Cytokines; Fusion Regulatory Protein-1; Galactosamine; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Pyrazines | 2020 |
KLF15 reduces the level of apoptosis in mouse liver induced by sepsis by inhibiting p38MAPK/ERK1/2 signaling pathway.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Galactosamine; Kruppel-Like Transcription Factors; Lipopolysaccharides; Liver; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Sepsis; Signal Transduction | 2020 |
Lactobacillus reuteri DSM 17938 alleviates d-galactosamine-induced liver failure in rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytokines; Disease Models, Animal; Dysbiosis; Galactosamine; Gastrointestinal Microbiome; Ileum; Inflammation Mediators; Limosilactobacillus reuteri; Liver; Liver Failure; Male; Metabolome; Peroxisome Proliferator-Activated Receptors; Probiotics; Rats, Sprague-Dawley; Signal Transduction; Transcriptome | 2021 |
Use of TLR9 and TLR7/8 agonists in combination with d-galactosamine in exploring models for distinct severities of systemic inflammation relative to liver injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Imidazoles; Inflammation; Lipopolysaccharides; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Severity of Illness Index; Toll-Like Receptor 7; Toll-Like Receptor 8; Toll-Like Receptor 9 | 2020 |
Nootkatone improves anxiety- and depression-like behavior by targeting hyperammonemia-induced oxidative stress in D-galactosamine model of liver injury.
Topics: Ammonia; Animals; Antidepressive Agents; Antioxidants; Anxiety; Behavior, Animal; Brain; Cell Survival; Chemical and Drug Induced Liver Injury; Depression; Galactosamine; Hyperammonemia; Lipopolysaccharides; Liver; Male; Malondialdehyde; Mice; Oxidative Stress; PC12 Cells; Polycyclic Sesquiterpenes; Rats | 2021 |
STAT6 up-regulation amplifies M2 macrophage anti-inflammatory capacity through mesenchymal stem cells.
Topics: Animals; Cell Communication; Cells, Cultured; Chemical and Drug Induced Liver Injury; Coculture Techniques; Disease Models, Animal; Galactosamine; Hepatocytes; Inflammation Mediators; Liver; Liver Failure, Acute; Macrophages; Male; Mesenchymal Stem Cell Transplantation; Phenotype; Rats, Wistar; Signal Transduction; STAT6 Transcription Factor; Up-Regulation | 2021 |
Paeonol derivative-6 attenuates inflammation by activating ZEB2 in acute liver injury.
Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Cell Line; Chemical and Drug Induced Liver Injury; Cytokines; Disease Models, Animal; Galactosamine; Humans; Inflammation Mediators; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Liver; Male; Mice, Inbred C57BL; Phosphorylation; Signal Transduction; Zinc Finger E-box Binding Homeobox 2 | 2021 |
Oridonin alleviates d-GalN/LPS-induced acute liver injury by inhibiting NLRP3 inflammasome.
Topics: Animals; Chemical and Drug Induced Liver Injury; Diterpenes, Kaurane; Galactosamine; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein | 2021 |
Fecal transplantation alleviates acute liver injury in mice through regulating Treg/Th17 cytokines balance.
Topics: Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Cytokines; Disease Models, Animal; Down-Regulation; Fecal Microbiota Transplantation; Galactosamine; Gastrointestinal Microbiome; Interleukin-10; Interleukin-17; Liver Function Tests; Male; Mice; Mice, Inbred BALB C; Principal Component Analysis; Saccharomyces boulardii; T-Lymphocytes, Regulatory; Th17 Cells; Up-Regulation | 2021 |
Sinapic acid ameliorates D-galactosamine/lipopolysaccharide-induced fulminant hepatitis in rats: Role of nuclear factor erythroid-related factor 2/heme oxygenase-1 pathways.
Topics: Animals; Chemical and Drug Induced Liver Injury; Coumaric Acids; Galactosamine; GATA1 Transcription Factor; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Lipopolysaccharides; Liver; Massive Hepatic Necrosis; NF-kappa B; Rats; Tumor Necrosis Factor-alpha | 2021 |
Lupeol ameliorates LPS/D-GalN induced acute hepatic damage by suppressing inflammation and oxidative stress through TGFβ1-Nrf2 signal pathway.
Topics: Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Down-Regulation; Galactosamine; Inflammation; Lipopolysaccharides; Mice, Inbred C57BL; NF-E2-Related Factor 2; Oxidative Stress; Pentacyclic Triterpenes; Transforming Growth Factor beta1; Up-Regulation; Zebrafish | 2021 |
NOD1 Agonist Protects Against Lipopolysaccharide and D-Galactosamine-Induced Fatal Hepatitis Through the Upregulation of A20 Expression in Hepatocytes.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Hepatocytes; Lipopolysaccharides; Male; Mice; Mice, Knockout; Nod1 Signaling Adaptor Protein; Tumor Necrosis Factor alpha-Induced Protein 3; Up-Regulation | 2021 |
Cyclin-dependent kinase inhibitor roscovitine attenuates liver inflammation and fibrosis by influencing initiating steps of liver injury.
Topics: Animals; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Galactosamine; Humans; Inflammation; Lipopolysaccharides; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Protein Kinase Inhibitors; RAW 264.7 Cells; Roscovitine; Sequence Analysis, RNA | 2021 |
Design and biological evaluation of novel long-acting adalimumab Fab conjugated with the albumin binding domain.
Topics: Adalimumab; Albumins; Animals; Anti-Inflammatory Agents; Cell Death; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Drug Design; Female; Galactosamine; Half-Life; Humans; Hydrogen-Ion Concentration; Immunoglobulin Fab Fragments; Injections, Intraperitoneal; Mice, Inbred BALB C; Necrosis; Protein Binding; Protein Domains; Receptors, Fc; Recombinant Fusion Proteins; Serum Albumin, Human; Tumor Necrosis Factor-alpha | 2021 |
Lipopolysaccharide/D-galactosamine-induced acute liver injury could be attenuated by dopamine receptor agonist rotigotine via regulating NF-κB signaling pathway.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dopamine Agonists; Galactosamine; Lipopolysaccharides; Liver; Male; Mice, Inbred BALB C; Microspheres; NF-kappa B; Signal Transduction; Tetrahydronaphthalenes; Thiophenes; Tumor Necrosis Factor-alpha | 2021 |
Andrographolide ameliorates d-galactosamine/lipopolysaccharide-induced acute liver injury by activating Nrf2 signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Diterpenes; Galactosamine; Heme Oxygenase-1; Interleukin-1beta; Lipopolysaccharides; Liver; Malondialdehyde; Mice, Inbred BALB C; NF-E2-Related Factor 2; NF-kappa B; Signal Transduction; Tumor Necrosis Factor-alpha | 2017 |
Saccharomyces boulardii Administration Changes Gut Microbiota and Attenuates D-Galactosamine-Induced Liver Injury.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; BALB 3T3 Cells; Chemical and Drug Induced Liver Injury; Galactosamine; Gastrointestinal Microbiome; Mice; Probiotics; Saccharomyces boulardii | 2017 |
[Components of human placental extract and its protective effect to rat from D-GalN induced acute liver injury].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Galactosamine; Humans; Liver; Male; Mice; Placental Extracts; Protective Agents; Random Allocation; Rats | 2017 |
The role of MAP2 kinases and p38 kinase in acute murine liver injury models.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Gene Knockdown Techniques; Hepatocytes; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 7; MAP Kinase Signaling System; Membrane Proteins; Mice; Microtubule-Associated Proteins; Mitochondria, Liver; Mitochondrial Proteins; Oligonucleotides, Antisense; p38 Mitogen-Activated Protein Kinases | 2017 |
Genipin protects d-galactosamine and lipopolysaccharide-induced hepatic injury through suppression of the necroptosis-mediated inflammasome signaling.
Topics: Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Galactosamine; Inflammasomes; Iridoids; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Necrosis; NLR Family, Pyrin Domain-Containing 3 Protein; Receptors, Pattern Recognition; Signal Transduction | 2017 |
Oeanolic acid protects against the hepatotoxicity of D-galactosame plus endotoxin in mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Endotoxins; Galactosamine; Lipopolysaccharides; Male; Mice; NF-kappa B; Oleanolic Acid; Protective Agents; Tumor Necrosis Factor-alpha | 2017 |
Lycopene Prevents Mitochondrial Dysfunction during d-Galactosamine/Lipopolysaccharide-Induced Fulminant Hepatic Failure in Albino Rats.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Binding Sites; Carotenoids; Chemical and Drug Induced Liver Injury; Citric Acid Cycle; Electron Transport Chain Complex Proteins; Galactosamine; Hydrogen Peroxide; Lipid Peroxidation; Lipopolysaccharides; Lipoxygenase Inhibitors; Lipoxygenases; Liver; Liver Failure, Acute; Lycopene; Male; Mitochondria; Molecular Docking Simulation; Oxidative Stress; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Rats; Rats, Wistar | 2017 |
Preventive effects of interleukin-6 in lipopolysaccharide/d-galactosamine induced acute liver injury via regulating inflammatory response in hepatic macrophages.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Galactosamine; Inflammation; Interleukin-6; Lipopolysaccharides; Liver; Macrophages; Mice; Mice, Inbred C57BL; RAW 264.7 Cells; Recombinant Proteins | 2017 |
Apigenin inhibits d-galactosamine/LPS-induced liver injury through upregulation of hepatic Nrf-2 and PPARγ expressions in mice.
Topics: Administration, Oral; Animals; Apigenin; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Galactosamine; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred ICR; NF-E2-Related Factor 2; PPAR gamma; Reactive Oxygen Species; Treatment Outcome; Up-Regulation | 2017 |
Autophagy and ER stress in LPS/GalN‑induced acute liver injury.
Topics: Alanine Transaminase; Animals; Autophagy; Beclin-1; CCAAT-Enhancer-Binding Proteins; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Stress; Galactosamine; Lipopolysaccharides; Liver; Male; Mice; Microtubule-Associated Proteins; Transcription Factor CHOP | 2017 |
Protective effects of tenuigenin on lipopolysaccharide and d-galactosamine-induced acute liver injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytokines; Drugs, Chinese Herbal; Galactosamine; Heme Oxygenase-1; Interleukin-1beta; Lipopolysaccharides; Liver; MAP Kinase Kinase Kinase 5; Membrane Proteins; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase Kinases; NF-E2-Related Factor 2; NF-kappa B; Tumor Necrosis Factor-alpha | 2017 |
Hepatoprotective effect of quercetin against LPS/d-GalN induced acute liver injury in mice by inhibiting the IKK/NF-κB and MAPK signal pathways.
Topics: Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Cytokines; Cytoprotection; Extracellular Signal-Regulated MAP Kinases; Female; Galactosamine; Inflammation Mediators; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Oxidative Stress; Quercetin; Signal Transduction | 2017 |
Deficiency of p38α in macrophage ameliorates d-galactosamine/TNF-α-induced acute liver injury in mice.
Topics: Animals; Antigens, Differentiation; Cell Cycle Proteins; Chemical and Drug Induced Liver Injury; Cyclic AMP Response Element-Binding Protein; Cytokines; Galactosamine; Hep G2 Cells; Hepatocytes; Humans; Immunophenotyping; Interferon-gamma; Lethal Dose 50; Lipopolysaccharides; Liver Regeneration; Macrophages; Male; MAP Kinase Signaling System; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 14; Phosphorylation; Protein Processing, Post-Translational; RAW 264.7 Cells; Tumor Necrosis Factor-alpha | 2017 |
Protective effects of oxymatrine against lipopolysaccharide/D‑galactosamine‑induced acute liver failure through oxidative damage, via activation of Nrf2/HO‑1 and modulation of inflammatory TLR4‑signaling pathways.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Drug Evaluation, Preclinical; Galactosamine; Gene Expression; Glutathione Peroxidase; Heme Oxygenase-1; Lipopolysaccharides; Liver; Liver Failure, Acute; Male; Malondialdehyde; Membrane Proteins; Mice, Inbred C57BL; NF-E2-Related Factor 2; Oxidative Stress; Protective Agents; Quinolizines; Signal Transduction; Superoxide Dismutase; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2018 |
Costunolide protects lipopolysaccharide/d-galactosamine-induced acute liver injury in mice by inhibiting NF-κB signaling pathway.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Injections, Intraperitoneal; Interleukin-1beta; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Protective Agents; Sesquiterpenes; Signal Transduction; Tumor Necrosis Factor-alpha | 2017 |
Toll-Like Receptor Ligand-Induced Liver Injury in D-Galactosamine-Sensitized Mice: Differences between TLR7/8 and TLR9 Ligands, Cytokine Patterns, and Cross-Tolerance Induction by TLR2 Ligand Pretreatment.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytokines; Female; Galactosamine; Imidazoles; Immune Tolerance; Immunization; Inflammation; Lectins; Membrane Glycoproteins; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Receptor Cross-Talk; Toll-Like Receptor 2; Toll-Like Receptor 7; Toll-Like Receptor 8; Toll-Like Receptor 9 | 2017 |
Diminazene aceturate alleviated lipopolysaccharide/D-galactosamine-induced fulminant hepatitis in mice.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Apoptosis; Aspartate Aminotransferases; Caspases; Chemical and Drug Induced Liver Injury; Diminazene; Galactosamine; Hepatitis; Interleukin-6; Lipopolysaccharides; Liver; Liver Failure, Acute; Male; Mice; Mice, Inbred BALB C; Tumor Necrosis Factor-alpha | 2018 |
Nuclear Receptor Subfamily 1 Group D Member 1 Regulates Circadian Activity of NLRP3 Inflammasome to Reduce the Severity of Fulminant Hepatitis in Mice.
Topics: Animals; Caspase 1; Cells, Cultured; Chemical and Drug Induced Liver Injury; Circadian Rhythm; Cytokines; Disease Models, Animal; Galactosamine; Genetic Predisposition to Disease; Inflammasomes; Lipopolysaccharides; Liver; Liver Failure, Acute; Macrophage Activation; Macrophages, Peritoneal; Mice, Knockout; NLR Family, Pyrin Domain-Containing 3 Protein; Nuclear Receptor Subfamily 1, Group D, Member 1; Peritonitis; Phenotype; Pyrrolidines; RNA Interference; Severity of Illness Index; Signal Transduction; Thiophenes; Time Factors; Transfection | 2018 |
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cells, Cultured; Chemical and Drug Induced Liver Injury; Galactosamine; Heme Oxygenase-1; Hepatocytes; Kelch-Like ECH-Associated Protein 1; Lipopolysaccharides; Liver; Male; Membrane Proteins; Mice; Mice, Inbred Strains; Morus; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; NF-kappa B; Plant Extracts; Signal Transduction; Stilbenes; Toll-Like Receptor 4 | 2018 |
Magnesium isoglycyrrhizinate attenuates D-galactosamine/lipopolysaccharides induced acute liver injury of rat via regulation of the p38-MAPK and NF-κB signaling pathways.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Lipopolysaccharides; Male; MAP Kinase Signaling System; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes | 2018 |
Isovitexin alleviates liver injury induced by lipopolysaccharide/d-galactosamine by activating Nrf2 and inhibiting NF-κB activation.
Topics: Animals; Apigenin; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Galactosamine; Gene Expression Regulation; Heme Oxygenase-1; Lipopolysaccharides; Liver; Liver Function Tests; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; NF-kappa B; Oryza; Phosphorylation; Plant Extracts; Signal Transduction; Tumor Necrosis Factor-alpha; Up-Regulation | 2018 |
Beta-sitosterol and its derivatives repress lipopolysaccharide/d-galactosamine-induced acute hepatic injury by inhibiting the oxidation and inflammation in mice.
Topics: Animals; Anti-Inflammatory Agents; Cell Survival; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Galactosamine; Inflammation; Lipopolysaccharides; Mice; Molecular Structure; Oxidation-Reduction; Sitosterols; Structure-Activity Relationship | 2018 |
Maslinic acid protects against lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Galactosamine; Heme Oxygenase-1; Interleukin-6; Lipopolysaccharides; Liver; Liver Function Tests; Membrane Proteins; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; NF-kappa B; Signal Transduction; Triterpenes; Tumor Necrosis Factor-alpha | 2018 |
Madecassoside prevents acute liver failure in LPS/D-GalN-induced mice by inhibiting p38/NF-κB and activating Nrf2/HO-1 signaling.
Topics: Animals; Antioxidants; Centella; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Heme Oxygenase-1; Lipopolysaccharides; Male; Membrane Proteins; Mice, Inbred Strains; NF-E2-Related Factor 2; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Signal Transduction; Triterpenes | 2018 |
Reduction in activating transcription factor 4 promotes carbon tetrachloride and lipopolysaccharide/D‑galactosamine‑mediated liver injury in mice.
Topics: Activating Transcription Factor 4; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; CRISPR-Cas Systems; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factor-2; Galactosamine; Gene Editing; Gene Expression Regulation; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Plasmids; Protective Factors; Tunicamycin | 2018 |
Protective effects of ginsenoside Rg1 against lipopolysaccharide/d-galactosamine-induced acute liver injury in mice through inhibiting toll-like receptor 4 signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytokines; Disease Models, Animal; Galactosamine; Ginsenosides; Humans; Inflammation Mediators; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Panax; Signal Transduction; Toll-Like Receptor 4 | 2018 |
Protective Effects of Sesquiterpenoids from the Root of Panax ginseng on Fulminant Liver Injury Induced by Lipopolysaccharide/d-Galactosamine.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Galactosamine; Heme Oxygenase-1; Humans; Interleukin-1beta; Lipopolysaccharides; Liver; Male; Malondialdehyde; Mice; Mice, Inbred ICR; NF-E2-Related Factor 2; Panax; Plant Roots; Protective Agents; Sesquiterpenes; Tumor Necrosis Factor-alpha | 2018 |
Liver-specific deletion of Eva1a/Tmem166 aggravates acute liver injury by impairing autophagy.
Topics: Alanine Transaminase; Animals; Apoptosis Regulatory Proteins; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Genotype; Interleukin-6; Lipopolysaccharides; Liver; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Peroxidase; Tumor Necrosis Factor-alpha | 2018 |
Diallyl sulfide protects against lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting oxidative stress, inflammation and apoptosis in mice.
Topics: Allyl Compounds; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Galactosamine; Inflammation; Lipopolysaccharides; Male; Mice, Inbred ICR; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Sulfides | 2018 |
Hepatoprotective effect of α-mangostin against lipopolysaccharide/d-galactosamine-induced acute liver failure in mice.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Galactosamine; Heme Oxygenase-1; Lipopolysaccharides; Liver; Liver Failure, Acute; Male; Membrane Proteins; Mice, Inbred ICR; NF-E2-Related Factor 2; Oxidative Stress; Signal Transduction; Toll-Like Receptor 4; Xanthones | 2018 |
Betulin inhibits lipopolysaccharide/D-galactosamine-induced acute liver injury in mice through activating PPAR-γ.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Galactosamine; Interleukin-1beta; Lipopolysaccharides; Liver; Male; Mice, Inbred BALB C; NF-kappa B; Peroxidase; PPAR gamma; Signal Transduction; Triterpenes; Tumor Necrosis Factor-alpha | 2018 |
The hepatoprotective effects of Radix Bupleuri extracts against D-galactosamine/lipopolysaccharide induced liver injury in hybrid grouper (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀).
Topics: Animals; Apoptosis; Bass; Cell Survival; Chemical and Drug Induced Liver Injury; Chimera; Female; Galactosamine; Gene Expression Regulation; Hepatocytes; Lipopolysaccharides; Liver; Male; Plant Extracts; Plant Roots; Protective Agents; Ranunculaceae | 2018 |
Protective effects of Coreopsis tinctoria flowers phenolic extract against D-galactosamine/lipopolysaccharide -induced acute liver injury by up-regulation of Nrf2, PPARα, and PPARγ.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Coreopsis; Flowers; Galactosamine; Gene Expression Regulation; Lipopolysaccharides; Male; Mice; NF-E2-Related Factor 2; Phenols; Plant Extracts; PPAR alpha; PPAR gamma | 2018 |
M1/M2-macrophage Polarization-based Hepatotoxicity in d-galactosamine-induced Acute Liver Injury in Rats.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Apoptosis; Chemical and Drug Induced Liver Injury; Cytokines; Galactosamine; Liver; Liver Function Tests; Macrophage Activation; Macrophages; Male; Necrosis; Rats, Inbred F344; Receptors, Cell Surface | 2018 |
Esculin prevents Lipopolysaccharide/D-Galactosamine-induced acute liver injury in mice.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cytokines; Disease Models, Animal; Esculin; Galactosamine; Lipopolysaccharides; Liver; Mice; Protective Agents | 2018 |
Carbon monoxide-induced TFEB nuclear translocation enhances mitophagy/mitochondrial biogenesis in hepatocytes and ameliorates inflammatory liver injury.
Topics: Active Transport, Cell Nucleus; Animals; Antimetabolites; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Biomarkers; Calcineurin; Carbon Monoxide; Chemical and Drug Induced Liver Injury; eIF-2 Kinase; Galactosamine; Gene Expression Regulation; Hepatocytes; Inflammation; Lipopolysaccharides; Liver; Lysosomes; Male; Mice; Mice, Inbred C57BL; Mitochondria; Mitophagy; Organelle Biogenesis; RNA, Small Interfering; Signal Transduction; Tripeptidyl-Peptidase 1; Ubiquitin-Protein Ligases | 2018 |
Humulus japonicus Extracts Protect Against Lipopolysaccharide/d-Galactosamine-Induced Acute Liver Injury in Rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Catalase; Chemical and Drug Induced Liver Injury; Galactosamine; Humans; Humulus; Lipopolysaccharides; Liver; Male; Malondialdehyde; Oxidative Stress; Plant Extracts; Protective Agents; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2018 |
Bifidobacterium adolescentis CGMCC 15058 alleviates liver injury, enhances the intestinal barrier and modifies the gut microbiota in D-galactosamine-treated rats.
Topics: Acute-Phase Proteins; Animals; Bifidobacterium adolescentis; Carrier Proteins; Chemical and Drug Induced Liver Injury; Cytokines; Dysbiosis; Feces; Galactosamine; Gastrointestinal Microbiome; Humans; Intestines; Liver; Male; Membrane Glycoproteins; Rats, Sprague-Dawley | 2019 |
Protective effects of alpinetin on lipopolysaccharide/d-Galactosamine-induced liver injury through inhibiting inflammatory and oxidative responses.
Topics: Alpinia; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Flavanones; Galactosamine; Heme Oxygenase-1; I-kappa B Proteins; Interleukin-1beta; Lipopolysaccharides; Liver; Malondialdehyde; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; Oxidative Stress; Peroxidase; Signal Transduction; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2019 |
Hepatoprotective effect of chiisanoside from Acanthopanax sessiliflorus against LPS/D-GalN-induced acute liver injury by inhibiting NF-κB and activating Nrf2/HO-1 signaling pathways.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Eleutherococcus; Galactosamine; Glutathione; Heme Oxygenase-1; Humans; Lipopolysaccharides; Liver; Male; Malondialdehyde; Mice; Mice, Inbred ICR; NF-E2-Related Factor 2; NF-kappa B; Oligosaccharides; Protective Agents; Signal Transduction; Superoxide Dismutase; Triterpenes | 2019 |
Short-term use of MyD88 inhibitor TJ-M2010-5 prevents d-galactosamine/lipopolysaccharide-induced acute liver injury in mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Gene Expression Regulation; Kupffer Cells; Lipopolysaccharides; Mice; Molecular Structure; Myeloid Differentiation Factor 88; Piperazines; Thiazoles | 2019 |
Rosmarinic acid protects mice from lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting MAPKs/NF-κB and activating Nrf2/HO-1 signaling pathways.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cinnamates; Depsides; Galactosamine; Gene Expression Regulation; Heme Oxygenase-1; Lipopolysaccharides; Mice; Mitogen-Activated Protein Kinase Kinases; NF-E2-Related Factor 2; NF-kappa B; Rosmarinic Acid | 2019 |
Amygdalin attenuates acute liver injury induced by D-galactosamine and lipopolysaccharide by regulating the NLRP3, NF-κB and Nrf2/NQO1 signalling pathways.
Topics: Amygdalin; Animals; Antineoplastic Agents, Phytogenic; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; Galactosamine; Hep G2 Cells; Humans; Lipopolysaccharides; Mice; Mice, Inbred BALB C; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Signal Transduction | 2019 |
Ultralow doses of dextromethorphan protect mice from endotoxin-induced sepsis-like hepatotoxicity.
Topics: Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Dextromethorphan; Endotoxins; Galactosamine; Kupffer Cells; Lipopolysaccharides; Mice; Oxidative Stress; Protective Agents; Reactive Oxygen Species; Sepsis; Shock, Septic; Survival Rate | 2019 |
Nrf2 signaling and autophagy are complementary in protecting lipopolysaccharide/d-galactosamine-induced acute liver injury by licochalcone A.
Topics: Animals; Autophagy; Carrier Proteins; Chalcones; Chemical and Drug Induced Liver Injury; Cytokines; Galactosamine; Inflammasomes; Lipopolysaccharides; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2; NF-kappa B; Protective Agents; Reactive Oxygen Species; Thioredoxins; Transcription Factor TFIIH | 2019 |
Saikosaponin a ameliorates lipopolysaccharide and d‑galactosamine-induced liver injury via activating LXRα.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Galactosamine; Hep G2 Cells; Humans; Interleukin-1beta; Lipopolysaccharides; Liver; Liver X Receptors; Malondialdehyde; Mice, Inbred C57BL; Oleanolic Acid; Peroxidase; Saponins; Tumor Necrosis Factor-alpha | 2019 |
The effects of vitamins and selenium mixture against brain tissue induced by d-galactosamine.
Topics: alpha-Tocopherol; Animals; Ascorbic Acid; beta Carotene; Brain; Brain Injuries; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Rats; Rats, Sprague-Dawley; Selenium | 2019 |
Dexmedetomidine alleviated lipopolysaccharide/D-galactosamine-induced acute liver injury in mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dexmedetomidine; Galactosamine; Lipopolysaccharides; Liver; Male; MAP Kinase Kinase 4; Mice, Inbred BALB C; Protective Agents; Tumor Necrosis Factor-alpha | 2019 |
Methyl 3,4-dihydroxybenzoate protects against d-galN/LPS-induced acute liver injury by inhibiting inflammation and apoptosis in mice.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; bcl-Associated Death Protein; bcl-X Protein; Chemical and Drug Induced Liver Injury; Galactosamine; Hydroxybenzoates; Inflammation; Interleukin-6; Lipopolysaccharides; Liver; Male; Mice; NF-kappa B p50 Subunit; p38 Mitogen-Activated Protein Kinases; RNA, Messenger; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2019 |
Protective effects of a novel water-soluble biphenyl compound WLP-S-14 against acute-on-chronic liver failure in rats.
Topics: Animals; Biphenyl Compounds; Chemical and Drug Induced Liver Injury; Galactosamine; Lipopolysaccharides; Liver; Male; Molecular Structure; Random Allocation; Rats; Rats, Wistar; Serum | 2019 |
Bioactive carbazole alkaloids from Murraya koenigii (L.) Spreng.
Topics: Alkaloids; Carbazoles; Cell Line; Chemical and Drug Induced Liver Injury; Enzyme Inhibitors; Galactosamine; Humans; Inhibitory Concentration 50; Liver; Molecular Structure; Murraya; Plant Extracts; Protein Tyrosine Phosphatase, Non-Receptor Type 1 | 2013 |
Inhibition of hepatocyte autophagy increases tumor necrosis factor-dependent liver injury by promoting caspase-8 activation.
Topics: Animals; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 7; Beclin-1; Caspase 8; Chemical and Drug Induced Liver Injury; Cytokines; Galactosamine; Hepatocytes; In Vitro Techniques; Lipopolysaccharides; Macrophages; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Microtubule-Associated Proteins; Models, Animal; Tumor Necrosis Factor-alpha | 2013 |
The involvement of heme oxygenase 1 but not nitric oxide synthase 2 in a hepatoprotective action of quercetin in lipopolysaccharide-induced hepatotoxicity of D-galactosamine sensitized rats.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Galactosamine; Heme Oxygenase-1; Lipopolysaccharides; Liver; Liver Failure; Male; Mice; Nitric Oxide Synthase; Nitrites; Phytotherapy; Plant Extracts; Quercetin; Rabbits; Rats; Rats, Wistar; RNA, Messenger; Transaminases | 2013 |
Ethyl pyruvate prevents inflammatory factors release and decreases intestinal permeability in rats with D-galactosamine-induced acute liver failure.
Topics: Animals; Anti-Inflammatory Agents; Bacterial Translocation; Biomarkers; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Endotoxins; Galactosamine; Inflammation Mediators; Intestinal Mucosa; Liver; Liver Failure, Acute; Male; Permeability; Pyruvates; Rats; Rats, Wistar; Time Factors | 2013 |
IL-25 prevents and cures fulminant hepatitis in mice through a myeloid-derived suppressor cell-dependent mechanism.
Topics: Animals; CD11b Antigen; Cell Proliferation; Chemical and Drug Induced Liver Injury; Coculture Techniques; Concanavalin A; Disease Models, Animal; Down-Regulation; Galactosamine; Hepatitis; Hepatocytes; Humans; Interleukin-17; Interleukins; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Myeloid Cells; Receptors, Chemokine; T-Lymphocytes | 2013 |
Lycopene stabilizes lipoprotein levels during D-galactosamine/lipopolysaccharide induced hepatitis in experimental rats.
Topics: Animals; Antioxidants; Carotenoids; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Hepatitis; Lipid Peroxidation; Lipoproteins; Liver; Lycopene; Male; Oxidative Stress; Rats; Rats, Wistar | 2012 |
Hepatoprotective effects of syringin on fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Eleutherococcus; Galactosamine; Glucosides; Lipopolysaccharides; Liver Failure, Acute; Liver Function Tests; Mice; Mice, Inbred BALB C; Phenylpropionates; Protective Agents; Survival Analysis | 2014 |
Hepatoprotective effect of the flavonoid fraction isolated from the flower of Inula britannica against D-Galactosamine-induced hepatic injury.
Topics: Administration, Oral; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cyclooxygenase 2; Flavonoids; Flowers; Galactosamine; Glutathione; Inula; Lipid Peroxidation; Male; Mice; Nitric Oxide Synthase Type II; RNA, Messenger; Tumor Necrosis Factor-alpha | 2013 |
Hepatoprotective effect of germanium-containing Spirulina in rats with (D)-galactosamine- and lipopolysaccharide-induced hepatitis.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Catalase; Chemical and Drug Induced Liver Injury; Dietary Supplements; Galactosamine; Germanium; Glutathione; Glutathione Peroxidase; Hepatitis; Interferon-gamma; Lipopolysaccharides; Liver; Male; Rats; Rats, Wistar; Spirulina; Tumor Necrosis Factor-alpha | 2014 |
Xiao-Chai-Hu Tang in treating model mice with D-galactosamine-induced liver injury.
Topics: Animals; bcl-2-Associated X Protein; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drugs, Chinese Herbal; fas Receptor; Galactosamine; Interleukin-6; Liver; Magnoliopsida; Mice; Phytotherapy; Proto-Oncogene Proteins c-bcl-2; Tumor Necrosis Factor-alpha | 2012 |
Hepatoprotective effect of cryptotanshinone from Salvia miltiorrhiza in D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Aspartate Aminotransferases; Caspases; Chemical and Drug Induced Liver Injury; Cytochromes c; Galactosamine; Lipopolysaccharides; Liver; Liver Failure, Acute; Male; MAP Kinase Kinase Kinases; Mice; Mice, Inbred C57BL; Mitochondria; Mitogen-Activated Protein Kinases; NF-kappa B; Phenanthrenes; Phytotherapy; Plant Extracts; Salvia miltiorrhiza; Tumor Necrosis Factor-alpha | 2014 |
Protection of a ceramide synthase 2 null mouse from drug-induced liver injury: role of gap junction dysfunction and connexin 32 mislocalization.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Ceramides; Chemical and Drug Induced Liver Injury; Connexins; Galactosamine; Gap Junction beta-1 Protein; Gap Junctions; Glutathione; Hepatocytes; Membrane Microdomains; Mice; Mice, Mutant Strains; Sphingosine N-Acyltransferase | 2013 |
Effect of lycopene on oxidative stress induced during D-galactosamine/lipopolysaccharide-sensitized liver injury in rats.
Topics: Animals; Antioxidants; Carotenoids; Chemical and Drug Induced Liver Injury; Comet Assay; Disease Models, Animal; DNA Damage; Galactosamine; Lipid Peroxidation; Lipid Peroxides; Lipopolysaccharides; Liver; Lycopene; Male; Oxidative Stress; Rats; Rats, Wistar | 2013 |
[Protective effect of soyasaponins on acute liver injury induced by D-galactosamine and lipopolysaccharide in mice].
Topics: Alanine Transaminase; Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; Caspases; Chemical and Drug Induced Liver Injury; Galactosamine; Glycine max; Lipopolysaccharides; Liver; Male; Mice; Saponins | 2013 |
Acute liver injury induces nucleocytoplasmic redistribution of hepatic methionine metabolism enzymes.
Topics: Acetaminophen; Acute Disease; Adenosylhomocysteinase; Animals; Chemical and Drug Induced Liver Injury; Cytoplasm; Galactosamine; Liver; Male; Methionine; Methionine Adenosyltransferase; Rats; Rats, Wistar; Tumor Cells, Cultured | 2014 |
Adenosine 5'-monophosphate ameliorates D-galactosamine/lipopolysaccharide-induced liver injury through an adenosine receptor-independent mechanism in mice.
Topics: Adenosine Monophosphate; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Humans; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Receptors, Purinergic P1; Tumor Necrosis Factor-alpha | 2014 |
Induction of Nrf2 and metallothionein as a common mechanism of hepatoprotective medicinal herbs.
Topics: Acetaminophen; Animals; Antioxidants; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Galactosamine; Glutamate-Cysteine Ligase; Heme Oxygenase-1; Liver; Male; Metallothionein; Mice; Mice, Inbred Strains; Molecular Targeted Therapy; NAD(P)H Dehydrogenase (Quinone); NADP; NF-E2-Related Factor 2; Oxidative Stress; Phytotherapy; Piper; Plant Extracts | 2014 |
[Protective effect of baicalin solid dispersion on D-galactosamine induced acute hepatic injury in mice].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Flavonoids; Galactosamine; Male; Malondialdehyde; Mice; Mice, Inbred Strains; Protective Agents; Superoxide Dismutase | 2014 |
Edaravone protects endotoxin-induced liver injury by inhibiting apoptosis and reducing proinflammatory cytokines.
Topics: Alanine Transaminase; Animals; Antipyrine; Apoptosis; Aspartate Aminotransferases; Caspase 3; Caspase 8; Chemical and Drug Induced Liver Injury; Cytokines; Edaravone; Endotoxins; Enzyme-Linked Immunosorbent Assay; Female; Free Radical Scavengers; Galactosamine; Hepatocytes; In Situ Nick-End Labeling; Interleukin-6; Lipopolysaccharides; Mice, Inbred BALB C; Random Allocation; Tumor Necrosis Factor-alpha | 2014 |
Protective effects of garcinol in mice with lipopolysaccharide/D-galactosamine-induced apoptotic liver injury.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; bcl-2-Associated X Protein; Chemical and Drug Induced Liver Injury; Galactosamine; Histone Acetyltransferases; Interleukin-6; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred BALB C; Protective Agents; Proto-Oncogene Proteins c-bcl-2; Terpenes; Tumor Necrosis Factor-alpha | 2014 |
[Morpho-functional characteristic of the duodenal crypt epithelium in the offspring of female rats with experimental liver injury].
Topics: Animals; Chemical and Drug Induced Liver Injury; Duodenum; Enterocytes; Epithelium; Female; Galactosamine; Humans; Intestinal Mucosa; Liver; Lymphocyte Count; Rats; Rats, Wistar | 2013 |
Administration of Lactobacillus salivarius LI01 or Pediococcus pentosaceus LI05 improves acute liver injury induced by D-galactosamine in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Cytokines; Galactosamine; Histocytochemistry; Ileum; Lactobacillus; Liver; Liver Function Tests; Pediococcus; Probiotics; Rats, Sprague-Dawley; Treatment Outcome | 2014 |
Lactate reduces liver and pancreatic injury in Toll-like receptor- and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity.
Topics: Animals; Anti-Inflammatory Agents; Arrestins; beta-Arrestin 2; beta-Arrestins; Carrier Proteins; Cell Line; Ceruletide; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Galactosamine; Humans; Immunity, Innate; Inflammasomes; Injections, Intraperitoneal; Interleukin-1beta; Lipopolysaccharides; Liver; Macrophages; Male; Mice; Mice, Inbred C57BL; Monocytes; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Pancreas; Pancreatitis; Receptors, G-Protein-Coupled; RNA Interference; RNA, Small Interfering; Signal Transduction; Sodium Lactate; Toll-Like Receptor 4; Toll-Like Receptors; Transfection | 2014 |
Protective mechanism of lignans from Phyllanthus amarus against galactosamine/ lipopolysaccharide-induced hepatitis: an in-vivo and in-silico studies.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Computer Simulation; Cytokines; Galactosamine; Lignans; Lipid Peroxidation; Lipopolysaccharides; Mice; Models, Chemical; Molecular Structure; Phyllanthus | 2014 |
Hepatoprotective triterpenes from traditional Tibetan medicine Potentilla anserina.
Topics: Animals; Cell Line; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Galactosamine; Hepatocytes; Macrophages; Male; Medicine, Tibetan Traditional; Mice; Mice, Inbred Strains; Molecular Conformation; Nitric Oxide; Plant Roots; Potentilla; Stereoisomerism; Structure-Activity Relationship; Triterpenes; Tumor Necrosis Factor-alpha | 2014 |
Quantitative proteomic analysis of hepatocyte-secreted extracellular vesicles reveals candidate markers for liver toxicity.
Topics: Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Exosomes; Galactosamine; Hepatocytes; Lipopolysaccharides; Liver; Male; Mass Spectrometry; Proteomics; Rats, Sprague-Dawley; Secretory Vesicles | 2014 |
Antioxidant activity and hepatoprotective effect of a polysaccharide from Bei Chaihu (Bupleurum chinense DC).
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Behavior, Animal; Bupleurum; Chemical and Drug Induced Liver Injury; Dipeptides; Galactosamine; Glutathione; Glutathione Reductase; Glutathione Transferase; L-Lactate Dehydrogenase; Liver; Male; Plant Roots; Polysaccharides; Protective Agents; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Tumor Necrosis Factor-alpha | 2012 |
Echinacoside ameliorates D-galactosamine plus lipopolysaccharide-induced acute liver injury in mice via inhibition of apoptosis and inflammation.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Apoptosis; Biomarkers; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Glycosides; Hepatocytes; Inflammation; Injections, Intraperitoneal; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Treatment Outcome | 2014 |
Comparison of the effects of the pretreatment and treatment with RhIL-11 on acute liver failure induced by D-galactosamine.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Cell Proliferation; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Drug Administration Schedule; Galactosamine; Humans; Interleukin-11; Liver; Liver Failure, Acute; Male; Proliferating Cell Nuclear Antigen; Protective Agents; Rats, Sprague-Dawley; Recombinant Proteins; Time Factors | 2014 |
Protective effect of SKLB010 against D-galactosamine/lipopolysaccharide-induced acute liver failure via nuclear factor-κB signaling pathway in macrophages.
Topics: Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Hepatocytes; Lipopolysaccharides; Liver; Liver Failure, Acute; Macrophages; Mice; Mice, Inbred BALB C; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protective Agents; RNA, Messenger; Signal Transduction; Thiazolidinediones; Tumor Necrosis Factor-alpha | 2014 |
Curcumin attenuates D-galactosamine/lipopolysaccharide-induced liver injury and mitochondrial dysfunction in mice.
Topics: Alanine Transaminase; Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Curcumin; Galactosamine; Gene Expression; Lipopolysaccharides; Liver; Liver Function Tests; Male; Malondialdehyde; Membrane Potential, Mitochondrial; Mice; Microscopy, Electron, Transmission; Mitochondria; Reactive Oxygen Species | 2014 |
D-galactosamine/lipopolysaccharide-induced hepatotoxicity downregulates sirtuin 1 in rat liver: role of sirtuin 1 modulation in hepatoprotection.
Topics: Animals; Antioxidants; Carbazoles; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Galactosamine; Lipid Peroxidation; Lipopolysaccharides; Liver; Male; Rats, Wistar; Resveratrol; Sirtuin 1; Stilbenes | 2014 |
Sodium butyrate protects against toxin-induced acute liver failure in rats.
Topics: Animals; Biomarkers; Butyric Acid; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Galactosamine; HMGB1 Protein; Inflammation Mediators; Interferon-gamma; Intestinal Mucosa; Intestines; Lipopolysaccharides; Liver; Liver Failure, Acute; Permeability; Protective Agents; Rats, Wistar; Serum Albumin; Serum Albumin, Human; Time Factors; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2014 |
The protective mechanism of schisandrin A in d-galactosamine-induced acute liver injury through activation of autophagy.
Topics: Animals; Autophagy; Chemical and Drug Induced Liver Injury; Cyclooctanes; Galactosamine; Lignans; Male; Mice; Mice, Inbred ICR; Polycyclic Compounds; Random Allocation; Schisandra | 2014 |
Anti-inflammatory and hepatoprotective effects of total flavonoid C-glycosides from Abrus mollis extracts.
Topics: Abrus; Animals; Anti-Inflammatory Agents; Biomarkers; Carbon Tetrachloride; Carrageenan; Chemical and Drug Induced Liver Injury; Edema; Female; Flavonoids; Galactosamine; Glycosides; Inflammation; Liver; Liver Cirrhosis; Male; Mice, Inbred ICR; Monosaccharides; Phytotherapy; Plant Extracts; Protective Agents; Rats, Sprague-Dawley; Xylenes | 2014 |
Role of the ¹³C-methacetin breath test in the assessment of acute liver injury in a rat model.
Topics: Acute Disease; Animals; Biomarkers; Biopsy; Breath Tests; Carbon Dioxide; Carbon Isotopes; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Fluorescent Dyes; Galactosamine; Indocyanine Green; Liver; Male; Oxyphenonium; Rats, Sprague-Dawley | 2014 |
Antidiabetic drug metformin is effective on the metabolism of asymmetric dimethylarginine in experimental liver injury.
Topics: Alanine Transaminase; Amidohydrolases; Animals; Arginine; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Galactosamine; Glutathione; Hypoglycemic Agents; Lipopolysaccharides; Male; Metformin; Peroxidase; Protective Agents; Rats; Rats, Sprague-Dawley | 2014 |
Alpha-lipoic acid exerts a liver-protective effect in acute liver injury rats.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Drug Evaluation, Preclinical; Galactosamine; Interleukin-10; Lipopolysaccharides; Liver; Male; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Rats, Sprague-Dawley; Thioctic Acid; Tumor Necrosis Factor-alpha | 2015 |
[CD38 protein reduces LPS/D-galactosamine-induced acute damage of liver tissues via down-regulating inflammatory cytokine expressions].
Topics: Acute Disease; ADP-ribosyl Cyclase 1; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cytokines; Disease Models, Animal; Down-Regulation; Galactosamine; Gene Expression; Inflammation Mediators; Injections, Intraperitoneal; Interferon-gamma; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Mice, Inbred C57BL; Mice, Knockout; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha | 2014 |
Protective effect of linalool against lipopolysaccharide/D-galactosamine-induced liver injury in mice.
Topics: Acyclic Monoterpenes; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Cyclooxygenase 2; Galactosamine; Interleukin-6; Lipid Peroxidation; Lipopolysaccharides; Liver Function Tests; Male; Mice, Inbred BALB C; Monoterpenes; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide Synthase Type II; Tumor Necrosis Factor-alpha | 2014 |
[Hepatoprotective effect of Hypecoum erectum extract on experimental D-galactosamine-induced damage of rat liver].
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; Catalase; Chemical and Drug Induced Liver Injury; Cholestasis; Cholesterol; Female; Galactosamine; Lipid Peroxidation; Liver; Male; Malondialdehyde; Papaveraceae; Plant Extracts; Protective Agents; Rats; Rats, Wistar | 2014 |
Carvacrol ameliorates the PPAR-A and cytochrome P450 expression on D-galactosamine induced hepatotoxicity rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cymenes; Cytochrome P-450 CYP2E1; Galactosamine; Gene Expression Regulation; Humans; Liver; Male; Monoterpenes; Plant Oils; PPAR alpha; Protective Agents; Rats; Rats, Wistar | 2014 |
Pretreatment of lipopolysaccharide (LPS) ameliorates D-GalN/LPS induced acute liver failure through TLR4 signaling pathway.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Drug Administration Schedule; Drug Tolerance; Galactosamine; Inflammation Mediators; Interleukin-1 Receptor-Associated Kinases; Lipopolysaccharides; Liver; Liver Failure, Acute; Male; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Toll-Like Receptor 4; Transcription Factor RelA | 2014 |
Pretreatment with wortmannin alleviates lipopolysaccharide/d-galactosamine-induced acute liver injury.
Topics: Alanine Transaminase; Androstadienes; Animals; Apoptosis; Aspartate Aminotransferases; Autophagy; Chemical and Drug Induced Liver Injury; Cytokines; Galactosamine; Hepatocytes; Immunohistochemistry; In Situ Nick-End Labeling; Inflammation; Lipopolysaccharides; Liver Failure, Acute; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Necrosis; Phosphoinositide-3 Kinase Inhibitors; Wortmannin | 2014 |
CYLD deletion triggers nuclear factor-κB-signaling and increases cell death resistance in murine hepatocytes.
Topics: Animals; Antibodies; Apoptosis; Biomarkers; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cysteine Endopeptidases; Deubiquitinating Enzyme CYLD; Disease Models, Animal; fas Receptor; Galactosamine; Gene Deletion; Hepatocytes; Lipopolysaccharides; Mice, Knockout; NF-kappa B; Receptors, Tumor Necrosis Factor; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha | 2014 |
The effects of modified sini decoction on liver injury and regeneration in acute liver failure induced by D-galactosamine in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Caspase 3; Chemical and Drug Induced Liver Injury; Cholinesterases; Drugs, Chinese Herbal; Galactosamine; HMGB1 Protein; Liver; Liver Failure, Acute; Male; NF-kappa B; Phytotherapy; Protective Agents; Prothrombin Time; Rats, Wistar; Regeneration; RNA, Messenger; Toll-Like Receptor 4 | 2015 |
Hybrid bioartificial liver support in cynomolgus monkeys with D-galactosamine-induced acute liver failure.
Topics: Animals; Biomarkers; Bioreactors; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Equipment Design; Feasibility Studies; Galactosamine; Hepatocytes; Humans; Liver; Liver Failure, Acute; Liver Function Tests; Liver, Artificial; Macaca fascicularis; Male; Time Factors | 2014 |
Hepatoprotective effect of nitric oxide in experimental model of acute hepatic failure.
Topics: Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Enzyme Inhibitors; Galactosamine; Liver; Liver Failure, Acute; Male; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Rats, Sprague-Dawley; Signal Transduction; Time Factors | 2014 |
Changing interdigestive migrating motor complex in rats under acute liver injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Digestion; Duodenum; Galactosamine; Gastrointestinal Motility; Humans; Liver; Myoelectric Complex, Migrating; Rats | 2014 |
Caloric restriction mimetic 2-deoxyglucose alleviated lethal liver injury induced by lipopolysaccharide/D-galactosamine in mice.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Biomimetics; Caloric Restriction; Caspases; Chemical and Drug Induced Liver Injury; Deoxyglucose; Galactosamine; Hepatocytes; Lipopolysaccharides; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Tumor Necrosis Factor-alpha | 2015 |
Protective effect of forsythiaside A on lipopolysaccharide/d-galactosamine-induced liver injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Forsythia; Fruit; Galactosamine; Glycosides; Lipid Peroxidation; Lipopolysaccharides; Liver Function Tests; Male; Mice, Inbred BALB C; NF-kappa B; Protective Agents; Tumor Necrosis Factor-alpha | 2015 |
Hepatoprotective effect of Commiphora myrrha against d-GalN/LPS-induced hepatic injury in a rat model through attenuation of pro inflammatory cytokines and related genes.
Topics: Animals; Chemical and Drug Induced Liver Injury; Commiphora; Cytokines; Disease Models, Animal; Galactosamine; Inflammation Mediators; Lipopolysaccharides; Male; Plant Extracts; Rats; Rats, Wistar | 2015 |
The effects of pentoxifylline and caffeic acid phenethyl ester in the treatment of d-galactosamine-induced acute hepatitis in rats.
Topics: Animals; Caffeic Acids; Caspase 3; Chemical and Drug Induced Liver Injury; Galactosamine; Glycogen; Ki-67 Antigen; Liver; Male; Malondialdehyde; Mast Cells; Pentoxifylline; Peroxidase; Phenylethyl Alcohol; Rats; Rats, Wistar | 2016 |
Isofuranodiene, the main volatile constituent of wild celery (Smyrnium olusatrum L.), protects d-galactosamin/lipopolysacchride-induced liver injury in rats.
Topics: Alanine Transaminase; Animals; Apiaceae; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Crops, Agricultural; Furans; Galactosamine; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Liver Diseases; Male; Malondialdehyde; Nitric Oxide Synthase Type II; Protective Agents; Rats; Rats, Sprague-Dawley | 2016 |
miR-150 Deficiency Protects against FAS-Induced Acute Liver Injury in Mice through Regulation of AKT.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Chemical and Drug Induced Liver Injury; Computational Biology; Enzyme Inhibitors; fas Receptor; Galactosamine; Gene Deletion; Gene Expression Regulation, Enzymologic; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hepatocytes; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Proto-Oncogene Proteins c-akt; Transaminases | 2015 |
Cerium oxide nanoparticles alleviate oxidative stress and decreases Nrf-2/HO-1 in D-GALN/LPS induced hepatotoxicity.
Topics: Animals; Cerium; Chemical and Drug Induced Liver Injury; Galactosamine; Heme Oxygenase-1; Lipid Peroxidation; Lipopolysaccharides; Male; Metal Nanoparticles; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Wistar | 2015 |
β-Caryophyllene alleviates D-galactosamine and lipopolysaccharide-induced hepatic injury through suppression of the TLR4 and RAGE signaling pathways.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytokines; Cytoprotection; Disease Models, Animal; Galactosamine; Inflammation Mediators; Kupffer Cells; Lipopolysaccharides; Liver; Liver Failure; Male; Mice, Inbred ICR; Mitogen-Activated Protein Kinases; Polycyclic Sesquiterpenes; Receptor for Advanced Glycation End Products; Sesquiterpenes; Signal Transduction; Time Factors; Toll-Like Receptor 4 | 2015 |
Protective effects of protostemonine on LPS/GalN-induced acute liver failure: Roles of increased hepatic expression of heme oxygenase-1.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cytokines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Galactosamine; Gene Expression Regulation, Enzymologic; Heme Oxygenase-1; Lactones; Lipopolysaccharides; Liver; Male; Mice; NF-E2-Related Factor 2; Oxidative Stress; Pyrrolidines | 2015 |
Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury.
Topics: Acetaminophen; Animals; Biomarkers; Brassica; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Galactosamine; Gene Expression Profiling; Gene Expression Regulation; Glutathione; Inactivation, Metabolic; Liver; Male; Oligonucleotide Array Sequence Analysis; Phytotherapy; Plant Extracts; Plants, Medicinal; Protective Agents; Rats, Wistar; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Seedlings; Time Factors | 2015 |
Recql5 protects against lipopolysaccharide/D-galactosamine-induced liver injury in mice.
Topics: Animals; Apoptosis; Caspase 3; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Cytokines; Disease Models, Animal; DNA Damage; Extracellular Signal-Regulated MAP Kinases; Galactosamine; Hepatocytes; Inflammation Mediators; Lipopolysaccharides; Liver; Male; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Infiltration; Oxidative Stress; Phosphorylation; RecQ Helicases; Signal Transduction; Time Factors | 2015 |
Ifit1 Protects Against Lipopolysaccharide and D-galactosamine-Induced Fatal Hepatitis by Inhibiting Activation of the JNK Pathway.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Carrier Proteins; Cell Line; Chemical and Drug Induced Liver Injury; Dependovirus; Disease Models, Animal; Galactosamine; Hepatitis; Hepatocytes; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Liver; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; RNA-Binding Proteins; Tumor Necrosis Factor-alpha | 2015 |
Heat shock proteins 27 and 70 contribute to the protection of Schisandrin B against d-galactosamine-induced liver injury in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cyclooctanes; Galactosamine; Gene Expression; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Lignans; Liver; Male; Mice; Mice, Inbred ICR; Polycyclic Compounds; Protective Agents; Quercetin; Schisandra | 2016 |
Mangiferin alleviates lipopolysaccharide and D-galactosamine-induced acute liver injury by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation.
Topics: Acute Disease; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Carrier Proteins; Chemical and Drug Induced Liver Injury; Cytoprotection; Galactosamine; Gene Expression Regulation, Enzymologic; Inflammasomes; Lipopolysaccharides; Liver; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; NLR Family, Pyrin Domain-Containing 3 Protein; Reactive Oxygen Species; Signal Transduction; Xanthones | 2016 |
Inhibition of sphingosine kinase 1 ameliorates acute liver failure by reducing high-mobility group box 1 cytoplasmic translocation in liver cells.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytoplasm; Cytoprotection; Disease Models, Animal; Down-Regulation; Galactosamine; HMGB1 Protein; Kupffer Cells; Liver; Liver Failure, Acute; Male; Mice, Inbred BALB C; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; Protein Transport; Signal Transduction; Sphingosine; Time Factors | 2015 |
Recombinant human soluble thrombomodulin improved lipopolysaccharide/d-galactosamine-induced acute liver failure in mice.
Topics: Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; HMGB1 Protein; Lipopolysaccharides; Liver; Male; Mice, Inbred C57BL; Neutrophils; Peroxidase; Recombinant Proteins; Solubility; Survival Rate; Thrombomodulin; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2015 |
The therapeutic effect of CORM-3 on acute liver failure induced by lipopolysaccharide/D-galactosamine in mice.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Bilirubin; Biomarkers; Chemical and Drug Induced Liver Injury; Cytokines; Cytoprotection; Disease Models, Animal; Galactosamine; Inflammation Mediators; Lipopolysaccharides; Liver; Liver Failure, Acute; Male; Mice, Inbred C57BL; Organometallic Compounds; Transcription Factor RelA | 2016 |
c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src.
Topics: Acetaminophen; Adaptor Proteins, Signal Transducing; Adenoviridae; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; JNK Mitogen-Activated Protein Kinases; Male; Membrane Proteins; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Liver; Mitochondrial Proteins; Protein Tyrosine Phosphatase, Non-Receptor Type 6; src-Family Kinases; Tumor Necrosis Factor-alpha | 2016 |
Comparative effects of Quercetin and SRT1720 against D-galactosamine/lipopolysaccharide-induced hepatotoxicity in rats: biochemical and molecular biological investigations.
Topics: Alanine Transaminase; Animals; Antioxidants; Bilirubin; Chemical and Drug Induced Liver Injury; Down-Regulation; Galactosamine; Heterocyclic Compounds, 4 or More Rings; Lipopolysaccharides; Male; Quercetin; Random Allocation; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Sirtuin 1 | 2016 |
Protective mechanisms of wogonoside against Lipopolysaccharide/D-galactosamine-induced acute liver injury in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cytoprotection; Flavanones; Galactosamine; Gene Expression Regulation, Enzymologic; Glucosides; Glutathione; Interleukin-1beta; Lipopolysaccharides; Liver; Male; Malondialdehyde; Mice; Mice, Inbred BALB C; NF-kappa B; Tumor Necrosis Factor-alpha | 2016 |
Cell-type-restricted anti-cytokine therapy: TNF inhibition from one pathogenic source.
Topics: Amino Acid Substitution; Animals; Antibodies, Bispecific; Antibodies, Neutralizing; Antibody Specificity; Antigen-Antibody Reactions; Antigens, Differentiation; Antigens, Surface; Camelus; Chemical and Drug Induced Liver Injury; Complementarity Determining Regions; Galactosamine; Genes, Synthetic; Humans; L Cells; Macrophages, Peritoneal; Mice; Mutation; Random Allocation; Recombinant Fusion Proteins; Single-Chain Antibodies; Tumor Necrosis Factor-alpha | 2016 |
Improved prescription of taohechengqi-tang alleviates D-galactosamine acute liver failure in rats.
Topics: Animals; Biomarkers; Cell Proliferation; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Drugs, Chinese Herbal; Galactosamine; Gene Expression Regulation; HMGB1 Protein; Liver; Liver Failure, Acute; Liver Regeneration; Male; Proliferating Cell Nuclear Antigen; Rats, Wistar; RNA, Messenger; Signal Transduction | 2016 |
Effect of silibinin and vitamin E on the ASK1-p38 MAPK pathway in D-galactosamine/lipopolysaccharide induced hepatotoxicity.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Galactosamine; Histocytochemistry; Lipopolysaccharides; Liver; Liver Function Tests; MAP Kinase Kinase Kinase 5; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Rats; Signal Transduction; Silybin; Silymarin; Treatment Outcome; Vitamin E | 2016 |
Protective effects of vitamin D3 against d-galactosamine-induced liver injury in rats.
Topics: Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cholecalciferol; Galactosamine; Hepatocytes; Humans; Liver; Rats | 2016 |
Biochanin A protects lipopolysaccharide/D-galactosamine-induced acute liver injury in mice by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation.
Topics: Animals; Anti-Inflammatory Agents; Carrier Proteins; Chemical and Drug Induced Liver Injury; Galactosamine; Genistein; Heme Oxygenase-1; Inflammasomes; Interleukin-1beta; Lipopolysaccharides; Liver; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; NLR Family, Pyrin Domain-Containing 3 Protein; Signal Transduction; Thioredoxins; Tumor Necrosis Factor-alpha | 2016 |
BML-111 Protected LPS/D-GalN-Induced Acute Liver Injury in Rats.
Topics: Acute Disease; Animals; Antioxidants; Blotting, Western; Chemical and Drug Induced Liver Injury; Cytokines; Galactosamine; Heptanoic Acids; Lipopolysaccharides; Male; Protective Agents; Rats; Rats, Sprague-Dawley | 2016 |
Effects of Salmonella infection on hepatic damage following acute liver injury in rats.
Topics: Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bacterial Translocation; Bilirubin; Biomarkers; CD3 Complex; Chemical and Drug Induced Liver Injury; Cytokines; Disease Models, Animal; Endotoxins; Galactosamine; Host-Pathogen Interactions; Liver; Male; Peyer's Patches; Rats, Sprague-Dawley; Salmonella enteritidis; Salmonella Infections; T-Lymphocytes; Time Factors | 2016 |
Cerbera manghas methanol extract exerts anti-inflammatory activity by targeting c-Jun N-terminal kinase in the AP-1 pathway.
Topics: Animals; Anti-Inflammatory Agents; Apocynaceae; Chemical and Drug Induced Liver Injury; Cytokines; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Galactosamine; HEK293 Cells; Humans; Inflammation Mediators; JNK Mitogen-Activated Protein Kinases; Kaempferols; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; Methanol; Mice; Mice, Inbred C57BL; Peritonitis; Phosphorylation; Phytotherapy; Plant Extracts; Plants, Medicinal; RAW 264.7 Cells; Signal Transduction; Solvents; Time Factors; Transcription Factor AP-1 | 2016 |
Induction of heat shock protein 27 by bicyclol attenuates d-galactosamine/lipopolysaccharide-induced liver injury.
Topics: Animals; Biphenyl Compounds; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Galactosamine; Gene Expression Regulation; Hepatocytes; HSP27 Heat-Shock Proteins; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL | 2016 |
Caspase Inhibition Prevents Tumor Necrosis Factor-α-Induced Apoptosis and Promotes Necrotic Cell Death in Mouse Hepatocytes in Vivo and in Vitro.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Autophagy; Caspase Inhibitors; Caspases; Cell Death; Chemical and Drug Induced Liver Injury; Galactosamine; Hepatocytes; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred BALB C; Models, Biological; Necrosis; NF-kappa B; Tumor Necrosis Factor-alpha | 2016 |
Protective effect of Xuebijing injection on D-galactosamine- and lipopolysaccharide-induced acute liver injury in rats through the regulation of p38 MAPK, MMP-9 and HO-1 expression by increasing TIPE2 expression.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blotting, Western; Chemical and Drug Induced Liver Injury; Cytokines; Drugs, Chinese Herbal; Galactosamine; Gene Expression Regulation; Heme Oxygenase-1; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Liver; Male; Malondialdehyde; Matrix Metalloproteinase 9; p38 Mitogen-Activated Protein Kinases; Peroxidase; Phytotherapy; Protective Agents; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Superoxide Dismutase; Survival Analysis | 2016 |
Bioactive alkaloids from the aerial parts of Houttuynia cordata.
Topics: Alkaloids; Cell Line; Chemical and Drug Induced Liver Injury; Cytoprotection; Drugs, Chinese Herbal; Enzyme Inhibitors; Galactosamine; Hepatocytes; Houttuynia; Liver; Molecular Structure; Phytotherapy; Plant Components, Aerial; Plants, Medicinal; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Structure-Activity Relationship | 2017 |
Nobiletin attenuates lipopolysaccharide/D‑galactosamine‑induced liver injury in mice by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF‑κB‑mediated cytokine production.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cyclooxygenase 2; Cytokines; Flavones; Galactosamine; Gene Expression; Gene Expression Regulation; Heme Oxygenase-1; Lipopolysaccharides; Liver Function Tests; Male; Mice; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide Synthase Type II; Signal Transduction | 2016 |
Hepatoprotective activity of Lepidium sativum seeds against D-galactosamine/lipopolysaccharide induced hepatotoxicity in animal model.
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Lepidium sativum; Lipopolysaccharides; Liver; Liver Failure, Acute; Liver Function Tests; Male; Phytotherapy; Plant Preparations; Protective Agents; Rats, Wistar; Seeds | 2016 |
Intraportal mesenchymal stem cell transplantation prevents acute liver failure through promoting cell proliferation and inhibiting apoptosis.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Cell Proliferation; Cells, Cultured; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Galactosamine; Liver; Liver Failure, Acute; Liver Function Tests; Liver Regeneration; Mesenchymal Stem Cell Transplantation; Phenotype; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Swine; Swine, Miniature; Time Factors | 2016 |
Tamoxifen Attenuates Lipopolysaccharide/Galactosamine-induced Acute Liver Failure by Antagonizing Hepatic Inflammation and Apoptosis.
Topics: Animals; Apoptosis; Caspase 3; Chemical and Drug Induced Liver Injury; Galactosamine; Humans; Interleukin-1beta; Lipopolysaccharides; Liver; Liver Failure, Acute; Mice; Mice, Inbred BALB C; Tamoxifen; Transaminases; Tumor Necrosis Factor-alpha | 2017 |
Protective roles of hepatic GABA signaling in acute liver injury of rats.
Topics: Animals; Baclofen; Chemical and Drug Induced Liver Injury; GABA-A Receptor Agonists; GABA-B Receptor Agonists; Galactosamine; gamma-Aminobutyric Acid; Hep G2 Cells; Hepatocytes; Humans; Liver; Male; Muscimol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2017 |
Protective effects of morin on lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting TLR4/NF-κB and activating Nrf2/HO-1 signaling pathways.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Flavonoids; Galactosamine; Heme Oxygenase-1; Hep G2 Cells; Humans; Lipopolysaccharides; Liver; Membrane Proteins; Mice; Mice, Inbred C57BL; Moraceae; NF-E2-Related Factor 2; NF-kappa B; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2017 |
Sirtuin-activating compounds (STACs) alleviate D-galactosamine/lipopolysaccharide-induced hepatotoxicity in rats: involvement of sirtuin 1 and heme oxygenase 1.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Heme Oxygenase (Decyclizing); Heterocyclic Compounds, 4 or More Rings; Lipopolysaccharides; Male; Random Allocation; Rats; Rats, Wistar; Sirtuin 1 | 2017 |
Hepatoprotective Effects of Nicotiflorin from Nymphaea candida against Concanavalin A-Induced and D-Galactosamine-Induced Liver Injury in Mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Concanavalin A; Cytokines; Disease Models, Animal; Flavonoids; Galactosamine; Liver Function Tests; Mice; Molecular Structure; Nymphaea; Oxidation-Reduction; Oxidative Stress; Phenols; Plant Extracts; Protective Agents | 2017 |
Contribution of hepatic stellate cells and matrix metalloproteinase 9 in acute liver failure.
Topics: Animals; Carbon Tetrachloride; Caspase 3; Chemical and Drug Induced Liver Injury; Collagen Type IV; Disease Models, Animal; Extracellular Matrix; Galactosamine; Gene Expression Regulation, Enzymologic; Hepatic Stellate Cells; Interleukin-1; Lipopolysaccharides; Liver; Liver Failure, Acute; Longevity; Male; Matrix Metalloproteinase 9; Mice; Mice, Knockout; Necrosis; Rats; Rats, Wistar; RNA, Messenger | 2008 |
L-Gln and L-Ser suppress the D-galactosamine-induced IL-18 expression and hepatitis.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Diet; Disease Models, Animal; Galactosamine; Glutamine; Interleukin-18; Male; Rats; Rats, Wistar; RNA, Messenger; Serine; Transaminases | 2008 |
Aqueous garlic extract attenuates hepatitis and oxidative stress induced by galactosamine/lipoploysaccharide in rats.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Galactosamine; Garlic; Lipopolysaccharides; Male; Oxidative Stress; Plant Extracts; Rats; Rats, Wistar | 2008 |
Protective effect of pinitol against D-galactosamine-induced hepatotoxicity in rats fed on a high-fat diet.
Topics: Animals; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Galactosamine; Inflammation; Inositol; Lipids; Male; Oxidative Stress; Protective Agents; Rats; Rats, Sprague-Dawley | 2008 |
[Protective effect of Isodon lophanthoides on acute hepatic injury induced by D-galactosamine in rats].
Topics: Acute Disease; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Female; Galactosamine; Isodon; Liver; Liver Diseases; Liver Glycogen; Male; Plants, Medicinal; Protective Agents; Random Allocation; Rats; Rats, Sprague-Dawley | 2008 |
Mechanism of the suppression against D-galactosamine-induced hepatic injury by dietary amino acids in rats.
Topics: Alanine Transaminase; Amino Acids; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Diet; Galactosamine; Guanidine; Humans; Liver; Male; Random Allocation; Rats; Rats, Wistar; Transaminases; Tumor Necrosis Factor-alpha | 2009 |
Influence of murine hepatitis induced by D-(+)-galactosamine hydrochloride and lipopolysaccharide on gene expression of polyethylenimine/plasmid DNA polyplex.
Topics: Animals; Chemical and Drug Induced Liver Injury; DNA; Drug Delivery Systems; Excipients; Galactosamine; Gene Expression; Gene Transfer Techniques; Genes, Reporter; Lipopolysaccharides; Liver; Liver Function Tests; Luciferases; Mice; Plasmids; Polyethyleneimine; Tissue Distribution | 2008 |
Anti-peroxidative and anti-hyperlipidemic nature of Ulva lactuca crude polysaccharide on D-galactosamine induced hepatitis in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Galactosamine; Hyperlipidemias; Lipid Peroxidation; Liver; Male; Polysaccharides; Rats; Rats, Wistar; Ulva | 2008 |
Differential roles of JNK in ConA/GalN and ConA-induced liver injury in mice.
Topics: Animals; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Caspase 8; Chemical and Drug Induced Liver Injury; Concanavalin A; Disease Models, Animal; Enzyme Activation; Fas-Associated Death Domain Protein; Galactosamine; Gene Deletion; JNK Mitogen-Activated Protein Kinases; Liver Diseases; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Mutant Proteins; Necrosis; Phosphorylation | 2008 |
A novel fluorescent probe for the detection of nitric oxide in vitro and in vivo.
Topics: Animals; Chemical and Drug Induced Liver Injury; Copper; Disease Models, Animal; Endothelial Cells; Fluorescent Dyes; Galactosamine; Humans; Imidazoles; Lipopolysaccharides; Liver Diseases; Macrophages; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Organometallic Compounds; Phenols; Time Factors | 2008 |
Mitochondrial modulation is involved in the hepatoprotection of Limonium sinense extract against liver damage in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blotting, Western; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Galactosamine; Lipopolysaccharides; Liver; Liver Diseases; Male; Medicine, Chinese Traditional; Membrane Potentials; Mice; Mice, Inbred ICR; Microscopy, Electron; Mitochondria, Liver; Plant Extracts; Plant Roots; Plumbaginaceae; Voltage-Dependent Anion Channels | 2008 |
Stabilization of mitochondrial and microsomal function by polysaccharide of Ulva lactuca on D-Galactosamine induced hepatitis in rats.
Topics: Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Hepatocytes; Injections, Intraperitoneal; Male; Microsomes, Liver; Mitochondria, Liver; Mitochondrial Membranes; Plant Extracts; Polysaccharides; Rats; Rats, Wistar; Trichloroacetic Acid; Ulva; Urea | 2009 |
Naltrexone protects against lipopolysaccharide/D-galactosamine-induced hepatitis in mice.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Antioxidants; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Neutrophils; Nitrates; Nitrites; Superoxides; Time Factors; Tumor Necrosis Factor-alpha | 2008 |
Influence of Piper betle on hepatic marker enzymes and tissue antioxidant status in D-galactosamine-induced hepatotoxic rats.
Topics: Alkaline Phosphatase; Animals; Antioxidants; Ascorbic Acid; Aspartate Aminotransferases; Biomarkers; Catalase; Chemical and Drug Induced Liver Injury; Galactosamine; gamma-Glutamyltransferase; Glutathione; Lipid Peroxidation; Liver; Male; Piper betle; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Silymarin; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Vitamin E | 2008 |
Xenotransplantation of human umbilical cord blood mononuclear cells to rats with D-galactosamine-induced hepatitis.
Topics: Animals; Biomarkers; Cells, Cultured; Chemical and Drug Induced Liver Injury; Fetal Blood; Galactosamine; Humans; Leukocytes, Mononuclear; Liver; Male; Rats; Rats, Wistar; Transplantation, Heterologous | 2008 |
Genetic delineation of the pathways mediated by bid and JNK in tumor necrosis factor-alpha-induced liver injury in adult and embryonic mice.
Topics: Animals; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Chemical and Drug Induced Liver Injury; Concanavalin A; Disease Models, Animal; Embryo, Mammalian; Galactosamine; Hepatocytes; Lipopolysaccharides; Liver; Liver Diseases; MAP Kinase Kinase 4; Mice; Mice, Knockout; Mitochondria, Liver; Mitogens; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2009 |
Liquiritigenin, a flavonoid aglycone from licorice, has a choleretic effect and the ability to induce hepatic transporters and phase-II enzymes.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Bile; Biotransformation; Carrier Proteins; Chemical and Drug Induced Liver Injury; Cholagogues and Choleretics; Disease Models, Animal; Enzymes; Epoxide Hydrolases; Flavanones; Galactosamine; Glucuronides; Glucuronosyltransferase; Glutathione Transferase; Heme Oxygenase (Decyclizing); Infusions, Intravenous; Isoenzymes; Lipopolysaccharides; Liver; Male; Metabolic Detoxication, Phase II; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Up-Regulation | 2009 |
Oxidant stress-induced liver injury in vivo: role of apoptosis, oncotic necrosis, and c-Jun NH2-terminal kinase activation.
Topics: Alanine Transaminase; Aldehydes; Animals; Antifibrinolytic Agents; Apoptosis; Caspases; Chemical and Drug Induced Liver Injury; Diquat; Disease Models, Animal; DNA Fragmentation; Endotoxins; Galactosamine; Glutathione Disulfide; Hepatocytes; In Situ Nick-End Labeling; JNK Mitogen-Activated Protein Kinases; Liver Diseases; Male; Necrosis; Oxidative Stress; Rats; Rats, Inbred F344; Superoxides; Vitamin K 3 | 2009 |
Influence of alpha lipoic acid on antioxidant status in D-galactosamine-induced hepatic injury.
Topics: Analysis of Variance; Animals; Antioxidants; Biomarkers; Catalase; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Glutathione; Glutathione Peroxidase; Injections, Intraperitoneal; Lipid Peroxidation; Liver; Liver Diseases; Male; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Thioctic Acid | 2008 |
Selective blockade of mGlu5 metabotropic glutamate receptors is hepatoprotective against fulminant hepatic failure induced by lipopolysaccharide and D-galactosamine in mice.
Topics: Alanine Transaminase; Animals; Ascorbic Acid; Aspartate Aminotransferases; Catalase; Chemical and Drug Induced Liver Injury; Excitatory Amino Acid Antagonists; Galactosamine; Glutathione Transferase; Injections, Intraperitoneal; Lipid Peroxidation; Lipopolysaccharides; Liver Failure, Acute; Mice; Protective Agents; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Survival Analysis | 2009 |
Effect of Piper betle on plasma antioxidant status and lipid profile against D-galactosamine-induced hepatitis in rats.
Topics: Analysis of Variance; Animals; Antioxidants; Ascorbic Acid; Chemical and Drug Induced Liver Injury; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Galactosamine; Glutathione; Injections, Intraperitoneal; Lipids; Male; Piper betle; Plant Extracts; Random Allocation; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Vitamin E | 2009 |
The inhibition of apoptosis by glycyrrhizin in hepatic injury induced by injection of lipopolysaccharide / D-galactosamine in mice.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Caspases; Chemical and Drug Induced Liver Injury; Galactosamine; Glycyrrhizic Acid; Hepatocytes; Immunohistochemistry; Injections; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Time Factors | 2008 |
Protective role of urinary trypsin inhibitor in lung expression of proinflammatory cytokines accompanied by lethal liver injury in mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytokines; Galactosamine; Gene Expression Regulation; Glycoproteins; Humans; Inflammation; Inflammation Mediators; Lipopolysaccharides; Lung; Male; Mice; Mice, Knockout | 2009 |
Role of the perforin/granzyme cell death pathway in D-Gal/LPS-induced inflammatory liver injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Etanercept; Galactosamine; Granzymes; Immunoglobulin G; Interleukin-6; Lipopolysaccharides; Liver; Liver Failure, Acute; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Necrosis; Pore Forming Cytotoxic Proteins; Receptors, Tumor Necrosis Factor; RNA, Messenger; Signal Transduction; T-Lymphocytes, Cytotoxic; Time Factors; Transaminases; Tumor Necrosis Factor-alpha | 2009 |
Protective effects of coffee-derived compounds on lipopolysaccharide/D-galactosamine induced acute liver injury in rats.
Topics: Alanine Transaminase; Alkaloids; Animals; Aspartate Aminotransferases; Caffeine; Chemical and Drug Induced Liver Injury; Chlorogenic Acid; Coffee; Galactosamine; Interleukin-10; Lipopolysaccharides; Liver Diseases; Male; Niacin; Pyrazinamide; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2009 |
Hepatoprotective effect of 3-alkynyl selenophene on acute liver injury induced by D-galactosamine and lipopolysaccharide.
Topics: Alanine Transaminase; Animals; Antioxidants; Ascorbic Acid; Aspartate Aminotransferases; Catalase; Chemical and Drug Induced Liver Injury; Galactosamine; Glutathione Transferase; Humans; Lipopolysaccharides; Liver; Liver Failure, Acute; Male; Molecular Structure; Organoselenium Compounds; Porphobilinogen Synthase; Rats; Rats, Wistar | 2009 |
Protective effect of Cichorium glandulosum root extract on carbon tetrachloride-induced and galactosamine-induced hepatotoxicity in mice.
Topics: Animals; Antioxidants; Asteraceae; Biphenyl Compounds; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Free Radical Scavengers; Free Radicals; Galactosamine; Hepatocytes; Lipid Peroxidation; Liver; Male; Mice; Nitric Oxide; Phytotherapy; Picrates; Plant Extracts; Plant Roots; Protective Agents; Superoxides | 2009 |
NFkappaB decoy delivery using dendritic poly(l-lysine) for treatment of endotoxin-induced hepatitis in mice.
Topics: Animals; Base Sequence; Chemical and Drug Induced Liver Injury; Cytokines; Dendrimers; Drug Carriers; Galactosamine; Lipopolysaccharides; Liver; Male; Mice; NF-kappa B; Oligonucleotides; Polylysine; RNA, Messenger; Transaminases | 2009 |
Cathepsin B inhibition improves lung injury associated to D-galactosamine/tumor necrosis factor-alpha-induced liver injury in mice.
Topics: Animals; Apoptosis; Cathepsin B; Cell Proliferation; Chemical and Drug Induced Liver Injury; Cysteine Proteinase Inhibitors; Diazomethane; Galactosamine; Lung Injury; Male; Mice; Mice, Inbred BALB C; Tumor Necrosis Factor-alpha | 2010 |
Effect of carvacrol on hepatic marker enzymes and antioxidant status in D-galactosamine-induced hepatotoxicity in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Biomarkers; Chemical and Drug Induced Liver Injury; Cymenes; Galactosamine; gamma-Glutamyltransferase; Glutathione Peroxidase; Kidney; Lipid Peroxidation; Liver; Male; Monoterpenes; Oxidative Stress; Rats; Rats, Wistar; Silymarin; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2009 |
Impaired hepatocyte regeneration in acute severe hepatic injury enhances effective repopulation by transplanted hepatocytes.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Hepatic Stellate Cells; Hepatocyte Growth Factor; Hepatocytes; Liver Failure, Acute; Liver Regeneration; Male; Matrix Metalloproteinase 2; Pyrrolizidine Alkaloids; Rats; Rats, Inbred F344; Transforming Growth Factor alpha; Up-Regulation | 2009 |
Protective effect of p-methoxyl-diphenyl diselenide in lethal acute liver failure induced by lipopolysaccharide and D-galactosamine in mice.
Topics: Administration, Oral; Alanine Transaminase; Animals; Antioxidants; Ascorbic Acid; Aspartate Aminotransferases; Benzene Derivatives; Catalase; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Galactosamine; Glutathione Transferase; Injections, Intraperitoneal; Lipopolysaccharides; Liver Failure, Acute; Male; Mice; Organoselenium Compounds | 2009 |
Intestinal glucose uptake protects liver from lipopolysaccharide and D-galactosamine, acetaminophen, and alpha-amanitin in mice.
Topics: Acetaminophen; Administration, Oral; Alpha-Amanitin; Animals; Chemical and Drug Induced Liver Injury; Fructose; Galactosamine; Glucose; Interleukin-10; Intestinal Mucosa; Lipopolysaccharides; Liver Diseases; Mice; Mice, Inbred C57BL; Signal Transduction; Sodium-Glucose Transporter 1; Sucrose; Toll-Like Receptor 4 | 2009 |
Yogurt: effect on leukocytes and blood coagulation in an acute liver injury model.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Coagulation; Cattle; Cell Death; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Fibrinogen; Galactosamine; Goats; Leukocyte Count; Leukocytes; Mice; Mice, Inbred BALB C; Neutrophil Infiltration; Neutrophils; Partial Thromboplastin Time; Peroxidase; Probiotics; Prothrombin Time; Yogurt | 2009 |
Lactobacillus casei: influence on the innate immune response and haemostatic alterations in a liver-injury model.
Topics: Animals; Blood Cell Count; Chemical and Drug Induced Liver Injury; Galactosamine; Immunity, Innate; Lacticaseibacillus casei; Liver; Liver Diseases; Mice; Mice, Inbred BALB C; Models, Biological; Probiotics | 2009 |
Expression levels of pituitary tumor transforming 1 and glutathione-S-transferase theta 3 are associated with the individual susceptibility to D-galactosamine-induced hepatotoxicity.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Glutathione Transferase; Liver; Liver Function Tests; Male; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA; Securin | 2010 |
Mechanistic aspects and novel biomarkers of responder and non-responder phenotypes in galactosamine-induced hepatitis.
Topics: Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Feces; Galactosamine; Humans; Liver; Male; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phenotype; Rats; Rats, Sprague-Dawley; Urine | 2009 |
A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-alpha expression.
Topics: Animals; Cell Division; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cysteine Endopeptidases; Fatty Liver; Galactosamine; Gene Expression; Hepatectomy; Hepatocytes; Hydrogen Peroxide; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Liver Failure, Acute; Liver Transplantation; Mice; Mice, Inbred BALB C; Mice, Knockout; Necrosis; Oxidants; PPAR alpha; Reperfusion Injury; Tumor Necrosis Factor alpha-Induced Protein 3 | 2009 |
Thy1-positive cells have bipotential ability to differentiate into hepatocytes and biliary epithelial cells in galactosamine-induced rat liver regeneration.
Topics: Animals; Biliary Tract; Cell Differentiation; Cell Separation; Chemical and Drug Induced Liver Injury; Epithelial Cells; Flow Cytometry; Galactosamine; Hepatocytes; Hyaluronan Receptors; Immunohistochemistry; Liver Regeneration; Male; Microscopy, Electron, Transmission; Oligonucleotide Array Sequence Analysis; Rats; Rats, Inbred F344; Stem Cells; Thy-1 Antigens | 2009 |
Hepatocyte transplantation and the differentiation fate of host oval cells in acute severe hepatic injury.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Differentiation; Chemical and Drug Induced Liver Injury; Dipeptidyl Peptidase 4; Galactosamine; Hepatocytes; Humans; Liver; Male; Pyrrolizidine Alkaloids; Random Allocation; Rats; Rats, Inbred F344 | 2010 |
The role of osteopontin in d-galactosamine-induced liver injury in genetically obese mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytokines; Galactosamine; Hepatocytes; Inflammation; Interleukin-12; Interleukin-18; Liver; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Osteopontin; Up-Regulation | 2010 |
The protective role of pregnane X receptor in lipopolysaccharide/D-galactosamine-induced acute liver injury.
Topics: Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Lipopolysaccharides; Male; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Pregnane X Receptor; Receptors, Steroid; STAT3 Transcription Factor | 2010 |
Antihepatotoxic activity of Saussurea lappa extract on D-galactosamine and lipopolysaccharide-induced hepatitis in mice.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred BALB C; Plant Extracts; Plant Roots; Protective Agents; Saussurea; Toxicity Tests, Acute | 2010 |
Effect of chrysin on hepatoprotective and antioxidant status in D-galactosamine-induced hepatitis in rats.
Topics: Animals; Antioxidants; Biomarkers; Catalase; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Erythrocytes; Flavonoids; Galactosamine; Glutathione Peroxidase; Kidney; Lipid Peroxidation; Liver; Male; Oxidative Stress; Protective Agents; Random Allocation; Rats; Rats, Wistar; Silymarin; Superoxide Dismutase | 2010 |
Effects of gut microflora on hepatic damage after acute liver injury in rats.
Topics: Animals; Bacterial Translocation; Chemical and Drug Induced Liver Injury; Cytokines; Endotoxins; Escherichia coli; Galactosamine; Gentamicins; Intestinal Mucosa; Intestines; Kidney; Liver; Liver Diseases; Lymph Nodes; Male; Mesentery; Peyer's Patches; Probiotics; Rats; Rats, Sprague-Dawley; Salmonella enteritidis; Spleen | 2010 |
Protection by dietary Spirulina platensis against D-galactosamine--and acetaminophen-induced liver injuries.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Diet; Galactosamine; Interleukin-18; Liver; Male; Malondialdehyde; Mice; Mice, Inbred ICR; RNA, Messenger; Spirulina; Thiobarbituric Acid Reactive Substances | 2010 |
Protective effects of Asiaticoside on acute liver injury induced by lipopolysaccharide/D-galactosamine in mice.
Topics: Animals; Base Sequence; Blotting, Western; Chemical and Drug Induced Liver Injury; DNA Primers; Galactosamine; Lipopolysaccharides; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Polymerase Chain Reaction; Triterpenes | 2010 |
1-methylmalate from camu-camu (Myrciaria dubia) suppressed D-galactosamine-induced liver injury in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Beverages; Chemical and Drug Induced Liver Injury; Citric Acid; Fruit; Galactosamine; Malates; Male; Myrtaceae; Rats; Rats, Wistar; Tartrates | 2010 |
Quantitative analyses and transcriptomic profiling of circulating messenger RNAs as biomarkers of rat liver injury.
Topics: Acetaminophen; Alanine Transaminase; Albumins; Analgesics, Non-Narcotic; Anesthetics, Local; Animals; Aspartate Aminotransferases; Biomarkers; Bupivacaine; Centrifugation, Density Gradient; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Fibrinogen; Galactosamine; Gene Expression Profiling; Haptoglobins; In Situ Hybridization; Liver; Male; Necrosis; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sensitivity and Specificity; Time Factors | 2010 |
Hepatoprotective effects of flavonoids from shekwasha (Citrus depressa) against D-galactosamine-induced liver injury in rats.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Citrus; DNA Fragmentation; Flavones; Flavonoids; Galactosamine; Lipopolysaccharides; Liver; Male; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase Type II; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; RNA, Messenger; Tumor Necrosis Factor-alpha | 2010 |
Influence of chrysin on hepatic marker enzymes and lipid profile against D-galactosamine-induced hepatotoxicity rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Flavonoids; Galactosamine; Liver; Male; Rats; Rats, Wistar | 2010 |
Protective effect of chloral hydrate against lipopolysaccharide/D-galactosamine-induced acute lethal liver injury and zymosan-induced peritonitis in mice.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chloral Hydrate; Cyclooxygenase 2; Cytokines; Cytoprotection; Dinoprostone; Galactosamine; Inflammation Mediators; Lipopolysaccharides; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide Synthase Type II; Peritonitis; Zymosan | 2010 |
Decreased IgA+ plasma cells and IgA expression in acute liver necrosis mice.
Topics: Acute Disease; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Galactosamine; Immunity, Mucosal; Immunoglobulin A; Interferon-gamma; Intestinal Mucosa; Intestine, Small; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred BALB C; Necrosis; Plasma Cells; Staining and Labeling | 2010 |
Possible role of LECT2 as an intrinsic regulatory factor in SEA-induced toxicity in d-galactosamine-sensitized mice.
Topics: Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Down-Regulation; Enterotoxins; Female; Flow Cytometry; Galactosamine; Hemorrhage; In Situ Nick-End Labeling; Intercellular Signaling Peptides and Proteins; Interleukin-6; Liver; Lung; Mice; Mice, Inbred C57BL; Shock, Septic; T-Lymphocytes; Time Factors; Tumor Necrosis Factor-alpha | 2010 |
Protective effect of Amaranthus spinosus against D-galactosamine/lipopolysaccharide-induced hepatic failure.
Topics: Amaranthus; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Female; Galactosamine; India; Lipopolysaccharides; Liver; Liver Failure; Male; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley | 2010 |
Activation of interleukin-6-induced glycoprotein 130/signal transducer and activator of transcription 3 pathway in mesenchymal stem cells enhances hepatic differentiation, proliferation, and liver regeneration.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Biomarkers; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chemotaxis; Coculture Techniques; Cytokine Receptor gp130; Disease Models, Animal; Female; Galactosamine; Gene Expression Regulation; Green Fluorescent Proteins; Hepatocytes; Interleukin-6; Liver Regeneration; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mitogen-Activated Protein Kinases; Paracrine Communication; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Signal Transduction; STAT3 Transcription Factor; Time Factors | 2010 |
Plasma microRNA-122 as a biomarker for viral-, alcohol-, and chemical-related hepatic diseases.
Topics: Adult; Alanine Transaminase; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Ethanol; Female; Galactosamine; Hepatitis B, Chronic; Humans; Liver Diseases; Male; Mice; Mice, Inbred BALB C; MicroRNAs; Muscle, Skeletal; Plasma | 2010 |
Influence of small doses of various drug vehicles on acetaminophen-induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Galactosamine; Lipopolysaccharides; Liver Function Tests; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver | 2010 |
Protective effect of Gö6976, a PKD inhibitor, on LPS/D: -GalN-induced acute liver injury in mice.
Topics: Animals; Apoptosis; Carbazoles; Caspases; Chemical and Drug Induced Liver Injury; Enzyme Activation; Enzyme Inhibitors; Galactosamine; Lipopolysaccharides; Liver; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Peroxidase; Protein Kinase C; Tumor Necrosis Factor-alpha | 2011 |
The synthetic bile acid-phospholipid conjugate ursodeoxycholyl lysophosphatidylethanolamide suppresses TNFα-induced liver injury.
Topics: Animals; Apoptosis; Cell Line; Chemical and Drug Induced Liver Injury; Cholagogues and Choleretics; Cytokines; Galactosamine; Gene Expression; Humans; Inflammation Mediators; Lipopolysaccharides; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Phosphatidylcholines; Phospholipases A2; Phospholipids; Tumor Necrosis Factor-alpha; Ursodeoxycholic Acid | 2011 |
Protective effects of Mg-CUD against D-galactosamine-induced hepatotoxicity in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Gene Expression Regulation, Enzymologic; Glutathione Disulfide; Heme Oxygenase-1; I-kappa B Kinase; Inflammation; Interleukin-10; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Lipid Peroxidation; Liver; Male; NF-kappa B; Organometallic Compounds; Oxidative Stress; Phosphoproteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transaminases; Tumor Necrosis Factor-alpha; Ursodeoxycholic Acid | 2011 |
Effect of globin digest on the liver injury and hepatic gene expression profile in galactosamine-induced liver injury in SD rats.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Gene Expression Regulation; Globins; Hepatocytes; Male; Mice; Phosphorylation; PPAR gamma; Proto-Oncogene Proteins c-met; Rats; Rats, Sprague-Dawley | 2011 |
Differential oxidative stress responses to D-galactosamine-lipopolysaccharide hepatotoxicity based on real time PCR analysis of selected oxidant/antioxidant and apoptotic gene expressions in rat.
Topics: Alanine Transaminase; Animals; Antioxidants; Apoptosis; Bilirubin; Caspase 3; Chemical and Drug Induced Liver Injury; Galactosamine; Gene Expression; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Heme Oxygenase-1; Lipopolysaccharides; Liver; Male; Oxidants; Oxidative Stress; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Superoxide Dismutase; Superoxide Dismutase-1 | 2011 |
Herbal formula CGX ameliorates LPS/D-galactosamine-induced hepatitis.
Topics: Animals; Antioxidants; Caspases; Chemical and Drug Induced Liver Injury; Galactosamine; Herbal Medicine; Immunologic Factors; Lipid Peroxidation; Lipopolysaccharides; Liver; Lymphocytes; Male; Mice; Mice, Inbred BALB C; Neutrophils; Oxidoreductases; Plant Extracts; Transaminases | 2011 |
Hepatoprotective effect of curcumin in lipopolysaccharide/-galactosamine model of liver injury in rats: relationship to HO-1/CO antioxidant system.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Monoxide; Chemical and Drug Induced Liver Injury; Curcuma; Curcumin; Disease Models, Animal; Galactosamine; Heme Oxygenase-1; Lipid Peroxidation; Lipopolysaccharides; Liver; Male; Nitric Oxide Synthase Type II; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Signal Transduction | 2011 |
Granulocyte colony-stimulating factor treatment ameliorates liver injury and improves survival in rats with D-galactosamine-induced acute liver failure.
Topics: Alanine Transaminase; Animals; Antigens, CD34; Chemical and Drug Induced Liver Injury; Female; Flow Cytometry; Galactosamine; Granulocyte Colony-Stimulating Factor; Liver; Rats; Rats, Sprague-Dawley; T-Lymphocytes | 2011 |
Ablation of c-FLIP in hepatocytes enhances death-receptor mediated apoptosis and toxic liver injury in vivo.
Topics: Animals; Anthracenes; Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspases; Chemical and Drug Induced Liver Injury; Concanavalin A; fas Receptor; Female; Galactosamine; Hepatocytes; Lipopolysaccharides; MAP Kinase Signaling System; Mice; Mice, Knockout; Receptors, Death Domain | 2011 |
Cytosolic phospholipase A(2)α protects against Fas- but not LPS-induced liver injury.
Topics: Animals; Apoptosis; Caspases; Chemical and Drug Induced Liver Injury; ErbB Receptors; fas Receptor; Female; Galactosamine; Gene Expression; Group IV Phospholipases A2; Hepatocytes; Humans; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Quinazolines; Recombinant Proteins; Tyrphostins | 2011 |
Amelioration of D-galactosamine-induced acute liver injury in rats by dietary supplementation with betaine derived from sugar beet molasses.
Topics: Adenosylhomocysteinase; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Beta vulgaris; Betaine; Chemical and Drug Induced Liver Injury; Dietary Supplements; Galactosamine; Glutathione; Glutathione Peroxidase; Glutathione Transferase; L-Lactate Dehydrogenase; Liver; Male; Molasses; Rats; S-Adenosylmethionine | 2011 |
Mouse strain-dependent caspase activation during acetaminophen hepatotoxicity does not result in apoptosis or modulation of inflammation.
Topics: Acetaminophen; Animals; Apoptosis; Caspase 3; Chemical and Drug Induced Liver Injury; Endotoxins; Fasting; Galactosamine; Glutathione; Hepatocytes; Inflammation; Male; Mice; Mice, Inbred C57BL; Neutrophils; Species Specificity | 2011 |
Triptolide attenuate the oxidative stress induced by LPS/D-GalN in mice.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Diterpenes; Epoxy Compounds; Galactosamine; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; NF-kappa B; Oxidative Stress; Phenanthrenes; Proteomics; Reactive Oxygen Species | 2012 |
Protection against TNFα-dependent liver toxicity by intraperitoneal liposome delivered DsiRNA targeting TNFα in vivo.
Topics: Animals; CD11b Antigen; Cell Culture Techniques; Cell Line; Chemical and Drug Induced Liver Injury; DEAD-box RNA Helicases; Disease Models, Animal; Down-Regulation; Flow Cytometry; Galactosamine; Injections, Intraperitoneal; Lipopolysaccharides; Liposomes; Macrophages; Mice; Mice, Inbred C57BL; Monocytes; Ribonuclease III; RNA, Small Interfering; Sepsis; Transfection; Tumor Necrosis Factor-alpha | 2012 |
Cyclooxygenase inhibitors protect D-galactosamine/lipopolysaccharide induced acute hepatic injury in experimental mice model.
Topics: Alanine Transaminase; Animals; Blotting, Western; Chemical and Drug Induced Liver Injury; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Galactosamine; Immunohistochemistry; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Nitric Oxide Synthase Type II; Reverse Transcriptase Polymerase Chain Reaction; Thiobarbituric Acid Reactive Substances; Tumor Necrosis Factor-alpha | 2012 |
Effects of globin digest and its active ingredient Trp-Thr-Gln-Arg on galactosamine/lipopolysaccharide-induced liver injury in ICR mice.
Topics: Analysis of Variance; Animals; Antioxidants; Cell Line; Chemical and Drug Induced Liver Injury; Chemokine CXCL2; Galactosamine; Globins; Hepatocytes; Lipopolysaccharides; Liver; Macrophages; Male; Mice; Mice, Inbred ICR; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oligopeptides; Peptide Fragments; Survival Rate; Transaminases; Tumor Necrosis Factor-alpha | 2012 |
Antidiabetic drug metformin alleviates endotoxin-induced fulminant liver injury in mice.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Caspases; Chemical and Drug Induced Liver Injury; Galactosamine; Hypoglycemic Agents; Lipopolysaccharides; Male; Malondialdehyde; Metformin; Mice; Mice, Inbred BALB C; Tumor Necrosis Factor-alpha | 2012 |
Pharmacometabonomic investigation of dynamic metabolic phenotypes associated with variability in response to galactosamine hepatotoxicity.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytokines; Feces; Galactosamine; Least-Squares Analysis; Liver; Male; Metabolome; Metabolomics; Nuclear Magnetic Resonance, Biomolecular; Rats; Rats, Sprague-Dawley | 2012 |
Hepatoprotective effect of Curcuma longa L. in D-galactosamine induced liver injury in mice: evidence of antioxidant activity.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Catalase; Chemical and Drug Induced Liver Injury; Curcuma; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Galactosamine; Glutathione; Injections, Intraperitoneal; Lipid Peroxidation; Liver; Male; Mice; Phytotherapy; Plant Extracts; Tocopherols; Treatment Outcome | 2010 |
Reference genes for real-time PCR quantification of microRNAs and messenger RNAs in rat models of hepatotoxicity.
Topics: Acetaminophen; Actins; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Galactosamine; Gene Expression; Gene Expression Profiling; Glyceraldehyde-3-Phosphate Dehydrogenases; Liver; MicroRNAs; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Nuclear; Thioacetamide | 2012 |
Proline protects liver from D-galactosamine hepatitis by activating the IL-6/STAT3 survival signaling pathway.
Topics: Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Hepatitis, Animal; Interleukin-6; Liver; Male; Proline; Rats; Rats, Inbred F344; Signal Transduction; STAT3 Transcription Factor; Survival Rate | 2012 |
Suppressive effect of modified arabinoxylan from rice bran (MGN-3) on D-galactosamine-induced IL-18 expression and hepatitis in rats.
Topics: Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Galactosamine; Gene Expression; Hepatitis, Animal; Injections, Intraperitoneal; Interleukin-18; Liver; Male; Molecular Weight; Oryza; Rats; Rats, Wistar; RNA, Messenger; Xylans | 2012 |
Protective effects of HV-P411 complex against D-galactosamine-induced hepatotoxicity in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Chemical and Drug Induced Liver Injury; Cyclooxygenase 2; Drugs, Chinese Herbal; Galactosamine; Glutathione; Heme Oxygenase-1; Interleukin-10; Interleukin-6; Lipid Peroxidation; Liver; Magnoliopsida; Male; NF-kappa B; Phosphorylation; Phytotherapy; Plants, Medicinal; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; RNA, Messenger; Schisandra; Seeds; Taraxacum; Tumor Necrosis Factor-alpha; Vitis | 2012 |
Human liver stem cells improve liver injury in a model of fulminant liver failure.
Topics: Adult Stem Cells; Animals; Apoptosis; Biomarkers; Chemical and Drug Induced Liver Injury; Culture Media, Conditioned; Galactosamine; Humans; Lipopolysaccharides; Liver; Liver Failure, Acute; Liver Regeneration; Male; Mice; Mice, SCID; Multipotent Stem Cells; Necrosis | 2013 |
Isolation of urinary exosomes from animal models to unravel noninvasive disease biomarkers.
Topics: Animals; Biomarkers; Centrifugation, Density Gradient; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Exosomes; Galactosamine; Glycine N-Methyltransferase; Humans; Mice; Mice, Knockout; Proteolysis; Proteome; Rats; Trypsin; Urinalysis | 2012 |
Pretreatment of hepatocyte growth factor gene transfer mediated by octaarginine peptide-modified nanoparticles ameliorates LPS/D-galactosamine-induced hepatitis.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Galactosamine; Gene Expression; Genes, Reporter; Genetic Therapy; Hepatitis; Hepatocyte Growth Factor; Lipopolysaccharides; Luciferases, Firefly; Male; Mice; Mice, Inbred BALB C; Nanoparticles; Oligopeptides; Peptides; Plasmids; Transfection | 2012 |
Brassica nigra plays a remedy role in hepatic and renal damage.
Topics: Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Galactosamine; Inflammation Mediators; Kidney; Kidney Diseases; Liver; Methanol; Mustard Plant; Oxidative Stress; Plant Extracts; Plant Leaves; Plants, Medicinal; Protective Agents; Rats; Rats, Wistar; Silymarin; Solvents | 2012 |
Differentiation capacity of hepatic stem/progenitor cells isolated from D-galactosamine-treated rat livers.
Topics: Adult Stem Cells; Animals; Cell Differentiation; Cells, Cultured; Chemical and Drug Induced Liver Injury; Epidermal Growth Factor; Epithelial Cells; Extracellular Matrix; Fibroblast Growth Factor 2; Galactosamine; Hepatocyte Growth Factor; Hepatocytes; Hyaluronan Receptors; Liver Regeneration; Male; Oligonucleotide Array Sequence Analysis; Rats; Rats, Inbred F344; Thy-1 Antigens | 2013 |
Hepatoprotective and antioxidant activity of Leucas aspera against D-galactosamine induced liver damage in rats.
Topics: Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Female; Galactosamine; Hexobarbital; Hypnotics and Sedatives; Lamiaceae; Lipid Peroxidation; Liver; Mice; Necrosis; Oxidative Stress; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Silymarin; Sleep; Time Factors | 2012 |
Low dose of carbon monoxide intraperitoneal injection provides potent protection against GalN/LPS-induced acute liver injury in mice.
Topics: Animals; Antioxidants; Apoptosis; Carbon Monoxide; Carboxyhemoglobin; Chemical and Drug Induced Liver Injury; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Galactosamine; Hepatocytes; Lipopolysaccharides; Liver; Liver Function Tests; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Oxidative Stress | 2013 |
Nitric oxide as a mediator of fructose 1,6-bisphosphate protection in galactosamine-induced hepatotoxicity in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Fructosediphosphates; Galactosamine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley | 2013 |
Protective effect of low molecular fraction of MGN-3, a modified arabinoxylan from rice bran, on acute liver injury by inhibition of NF-κB and JNK/MAPK expression.
Topics: Animals; Caspase 1; Chemical and Drug Induced Liver Injury; Galactosamine; Gene Expression Regulation; I-kappa B Kinase; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharide Receptors; Mitogen-Activated Protein Kinase Kinases; NF-kappa B; Oryza; Rats; Rats, Wistar; Signal Transduction; Toll-Like Receptor 4; Xylans | 2012 |
Protective effects of probiotic Lactobacillus casei Zhang against endotoxin- and d-galactosamine-induced liver injury in rats via anti-oxidative and anti-inflammatory capacities.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Chemical and Drug Induced Liver Injury; Endotoxins; Galactosamine; Lacticaseibacillus casei; Male; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase Type II; Probiotics; Rats; Rats, Wistar; Superoxide Dismutase; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2013 |
Antihepatotoxic activity of a quantified Desmodium adscendens decoction and D-pinitol against chemically-induced liver damage in rats.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Ethanol; Fabaceae; Galactosamine; Inositol; Male; Phytotherapy; Plant Extracts; Plant Leaves; Plant Stems; Protective Agents; Rats; Rats, Sprague-Dawley; Rats, Wistar | 2013 |
The inhibitory action of PDCD4 in lipopolysaccharide/D-galactosamine-induced acute liver injury.
Topics: Alanine Transaminase; Animals; Apoptosis Regulatory Proteins; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Galactosamine; Immunohistochemistry; In Situ Nick-End Labeling; Interleukin-6; Lipopolysaccharides; Liver; Mice; NF-kappa B; Organ Size; RNA-Binding Proteins; Tumor Necrosis Factor-alpha | 2013 |
Synergistic effects of antibodies against high-mobility group box 1 and tumor necrosis factor-α antibodies on D-(+)-galactosamine hydrochloride/lipopolysaccharide-induced acute liver failure.
Topics: Alanine Transaminase; Animals; Antibodies, Monoclonal; Antibodies, Neutralizing; Chemical and Drug Induced Liver Injury; Drug Synergism; Female; Galactosamine; HMGB1 Protein; Immunohistochemistry; Interleukin-6; Lipopolysaccharides; Liver; Liver Failure, Acute; Mice; Mice, Inbred C57BL; Necrosis; Nitric Oxide Synthase Type II; Protein Interaction Mapping; Tumor Necrosis Factor-alpha | 2013 |
[Hepatoprotective effect of several constituents of Lonicera fulvotomentosa hsu et S. C. cheng, and L. macranthoide Hand.-Mazz. on CC1(4) and D-galactosamine induced liver injuries in mice and rats].
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Galactosamine; Liver; Lonicera; Malondialdehyde; Mice; Plants, Medicinal; Protective Agents; Rats; Rats, Wistar; Triglycerides | 1999 |
Effects of anti-ulcer agents on ethanol-induced gastric mucosal lesions in D-galactosamine-induced hepatitis rats.
Topics: Abietanes; Animals; Anti-Ulcer Agents; Central Nervous System Depressants; Chemical and Drug Induced Liver Injury; Diterpenes; Dose-Response Relationship, Drug; Ethanol; Galactosamine; Gastric Mucosa; Liver Function Tests; Male; Rats; Rats, Inbred F344; Stomach Ulcer | 2002 |
Cytokine modulation and suppression of liver injury by a novel analogue of thalidomide.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Barbiturates; Cell Division; Chemical and Drug Induced Liver Injury; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytokines; Flow Cytometry; Galactosamine; Humans; Interleukin-10; Interleukin-6; Lipopolysaccharides; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Monocytes; Phthalimides; RNA, Messenger; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2002 |
Differential effects of dietary casein and soybean protein isolate on lipopolysaccharide-induced hepatitis in D-galactosamine-sensitized rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Caseins; Chemical and Drug Induced Liver Injury; Diet; Eating; Galactosamine; Glutathione; Lipopolysaccharides; Liver; Male; Organ Size; Oxidation-Reduction; Rats; Rats, Wistar; Soybean Proteins | 2002 |
A recombinant adenovirus encoding hepatitis C virus core and E1 proteins protects mice against cytokine-induced liver damage.
Topics: Acute Disease; Adenoviridae; Animals; Cell Nucleus; Chemical and Drug Induced Liver Injury; Concanavalin A; Cytokines; Drug Combinations; Female; Galactosamine; Gene Expression; Hepacivirus; Liver Diseases; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Recombination, Genetic; Transduction, Genetic; Tumor Necrosis Factor-alpha; Viral Core Proteins; Viral Envelope Proteins | 2003 |
[Experimental studies on pharmacodynamic effect of Macleaya cordata].
Topics: Albumins; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Female; Galactosamine; Globulins; Hypersensitivity, Delayed; L-Lactate Dehydrogenase; Liver Function Tests; Male; Mice; Papaveraceae; Plants, Medicinal; Rats; Rats, Wistar | 1999 |
[Study on hepatic-protective effect of "yinzhihuang" granula].
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drugs, Chinese Herbal; Galactosamine; Liver; Mice; Protective Agents; Rats | 2001 |
Hepatoprotective effect of myristicin from nutmeg (Myristica fragrans) on lipopolysaccharide/d-galactosamine-induced liver injury.
Topics: Alanine Transaminase; Allylbenzene Derivatives; Animals; Aspartate Aminotransferases; Benzyl Compounds; Chemical and Drug Induced Liver Injury; Diet; Dioxolanes; DNA Fragmentation; Galactosamine; Lipopolysaccharides; Liver; Liver Diseases; Male; Mice; Myristica; Oils, Volatile; Pyrogallol; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2003 |
Overexpression of thioredoxin prevents acute hepatitis caused by thioacetamide or lipopolysaccharide in mice.
Topics: Acute Disease; Animals; Antibodies; Apoptosis; Chemical and Drug Induced Liver Injury; Down-Regulation; fas Receptor; Galactosamine; Humans; Lipopolysaccharides; Liver Failure; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Survival Rate; Thioacetamide; Thioredoxins | 2003 |
Glycosmis arborea extract as a hepatoprotective agent.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Body Weight; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Galactosamine; Lethal Dose 50; Lipid Peroxidation; Liver; Liver Diseases; Male; Mice; Mice, Inbred BALB C; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Rutaceae; Superoxide Dismutase; Survival Rate; Toxicity Tests, Acute | 2003 |
STAT1 plays an essential role in LPS/D-galactosamine-induced liver apoptosis and injury.
Topics: Animals; Apoptosis; Cell Line; Chemical and Drug Induced Liver Injury; DNA Fragmentation; DNA-Binding Proteins; Flow Cytometry; Galactosamine; Hepatocytes; Interferon-gamma; Lipopolysaccharides; Liver Diseases; Mice; Mice, Inbred BALB C; Mice, Knockout; Phosphorylation; Phosphotyrosine; STAT1 Transcription Factor; Trans-Activators; Transfection; Tumor Necrosis Factor-alpha | 2003 |
Serine proteases of the fibrinolysis pathway are not involved in lethal hepatitis and fibrinogen breakdown induced by tumor necrosis factor.
Topics: Alanine Transaminase; Animals; Blood Coagulation; Chemical and Drug Induced Liver Injury; Fibrinogen; Fibrinolysin; Fibrinolysis; Galactosamine; Matrix Metalloproteinase 9; Mice; Mice, Mutant Strains; Plasminogen; Serine Endopeptidases; Tissue Plasminogen Activator; Tumor Necrosis Factor-alpha; Urokinase-Type Plasminogen Activator | 2003 |
Oncotic necrosis and caspase-dependent apoptosis during galactosamine-induced liver injury in rats.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Caspase Inhibitors; Caspases; Chemical and Drug Induced Liver Injury; Female; Galactosamine; In Situ Nick-End Labeling; Necrosis; Rats; Rats, Sprague-Dawley; Uridine | 2003 |
The hepatoprotective effects of Limonium sinense against carbon tetrachloride and beta-D-galactosamine intoxication in rats.
Topics: Administration, Oral; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Galactosamine; Humans; Injections, Intraperitoneal; Lethal Dose 50; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred ICR; Phytotherapy; Plant Extracts; Plant Leaves; Plant Roots; Plumbaginaceae; Protective Agents; Rats; Rats, Wistar; Triglycerides | 2003 |
Silibinin protects mice from T cell-dependent liver injury.
Topics: Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Concanavalin A; Cytokines; Cytoprotection; Enzyme Induction; Galactosamine; Leukocytes; Liver; Liver Diseases; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Recombinant Proteins; RNA, Messenger; Silybin; Silymarin; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2003 |
Hepatoprotective effect of allicin on tissue defense system in galactosamine/endotoxin challenged rats.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Disulfides; Endotoxins; Escherichia coli; Galactosamine; Male; Rats; Rats, Wistar; Sulfinic Acids | 2004 |
Hepatobiliary clearance of labelled mebrofenin in normal and D-galactosamine HCl-induced hepatitis rats and the protective effect of turmeric extract.
Topics: Alanine Transaminase; Alkaline Phosphatase; Aniline Compounds; Animals; Aspartate Aminotransferases; Bile; Chemical and Drug Induced Liver Injury; Curcuma; Galactosamine; Glycine; Imino Acids; Injections, Intravenous; Liver; Liver Function Tests; Male; Organotechnetium Compounds; Phytotherapy; Plant Roots; Radiopharmaceuticals; Rats; Rats, Wistar; Tissue Distribution | 2003 |
Suppression by Hydrangeae Dulcis Folium of D-galactosamine-induced liver injury in vitro and in vivo.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Hydrangea; Liver; Liver Diseases; Phytotherapy; Plant Extracts; Rats; Rats, Wistar | 2003 |
Ingestion of resistant starch protects endotoxin influx from the intestinal tract and reduces D-galactosamine-induced liver injury in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Endotoxins; Galactosamine; Intestines; Liver Diseases; Male; Portal Vein; Rats; Rats, Wistar; Starch; Transaminases | 2004 |
Hepatoprotective effect of taxiresinol and (7'R)-7'-hydroxylariciresinol on D-galactosamine and lipopolysaccharide-induced liver injury in mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Furans; Galactosamine; Lignans; Lipopolysaccharides; Male; Mice; Phytotherapy; Plant Extracts; Plants, Medicinal; Protective Agents; Trees | 2004 |
[Protective effect of curcumin on experimental liver injury in mice].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Curcumin; Galactosamine; Lipopolysaccharides; Liver; Liver Diseases; Male; Malondialdehyde; Mice; Nitric Oxide; Protective Agents | 2003 |
[A comparison of the protective activity of liver injury induced by D-galact-osamine between huangqin-tang and their metabolites by human intestinal bacteria].
Topics: Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bacteria; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Galactosamine; Intestines; Liver Diseases; Male; Mice; Plants, Medicinal; Protective Agents | 2003 |
Substitution for natural musk in Pien Tze Huang does not affect its hepatoprotective activities.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Fatty Acids, Monounsaturated; Galactosamine; Gas Chromatography-Mass Spectrometry; Mice; Mice, Inbred ICR | 2004 |
Secoisolariciresinol and isotaxiresinol inhibit tumor necrosis factor-alpha-dependent hepatic apoptosis in mice.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Butylene Glycols; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Therapy, Combination; Furans; Galactosamine; Injections, Intraperitoneal; Interferon-gamma; Lignans; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred Strains; Phytotherapy; Plant Extracts; Plants, Medicinal; Taxus; Tumor Necrosis Factor-alpha | 2004 |
Effect of Acanthopanax koreanum Nakai (Araliaceae) on D-galactosamine and lipopolysaccharide-induced fulminant hepatitis.
Topics: Administration, Oral; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Eleutherococcus; Galactosamine; Hepatocytes; Injections, Intraperitoneal; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Phytotherapy; Plant Extracts; Plant Roots; Plant Stems; Protective Agents; Tumor Necrosis Factor-alpha | 2004 |
High, but not low, molecular weight hyaluronan prevents T-cell-mediated liver injury by reducing proinflammatory cytokines in mice.
Topics: Adjuvants, Immunologic; Animals; Chemical and Drug Induced Liver Injury; Concanavalin A; Cytokines; Female; Galactosamine; Hyaluronic Acid; Infusions, Intravenous; Lipopolysaccharides; Liver Diseases; Male; Mice; Models, Animal; Molecular Weight; T-Lymphocytes | 2004 |
Liver dysfunction induced by bile duct ligation and galactosamine injection alters cardiac protein synthesis.
Topics: Algorithms; Animals; Bile Ducts; Chemical and Drug Induced Liver Injury; DNA; Galactosamine; Kinetics; Ligation; Liver Diseases; Male; Malnutrition; Myocardium; Organ Size; Phenylalanine; Protein Biosynthesis; Rats; Rats, Wistar; RNA | 2004 |
Antioxidant activity of medicinal herb Rhodococcum vitis-idaea on galactosamine-induced liver injury in rats.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Ericaceae; Galactosamine; Male; Phytotherapy; Plant Extracts; Plant Leaves; Protective Agents; Rats; Rats, Wistar | 2004 |
Mechanisms of hepatoprotection of Terminalia catappa L. extract on D-Galactosamine-induced liver damage.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; Galactosamine; Hepatocytes; Liver; Male; Mice; Mice, Inbred ICR; Mitochondria; Phytotherapy; Plant Extracts; Plant Leaves; Pregnancy; Superoxide Dismutase; Terminalia; Triterpenes | 2004 |
Cooperative effect of biliverdin and carbon monoxide on survival of mice in immune-mediated liver injury.
Topics: Animals; Biliverdine; Carbon Monoxide; Chemical and Drug Induced Liver Injury; Cytokines; Drug Synergism; Ferritins; Galactosamine; Gene Transfer Techniques; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Immune System Diseases; Immunization; Interferon-gamma; Lipopolysaccharides; Membrane Proteins; Mice; Mice, Inbred BALB C; Survival Analysis; Tumor Necrosis Factor-alpha | 2004 |
Screening on the pharmacodynemic active parts of protecting liver of Peristrope japonica (Thunb.) Bremek.
Topics: Acanthaceae; Animals; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Female; Galactosamine; Liver Function Tests; Male; Phytotherapy; Protective Agents; Random Allocation; Rats | 2004 |
New isoflavones and pterocarpane with hepatoprotective activity from the stems of Erycibe expansa.
Topics: Animals; Chemical and Drug Induced Liver Injury; Convolvulaceae; Galactosamine; Hepatocytes; Inhibitory Concentration 50; Isoflavones; Mice; Phytotherapy; Plant Extracts; Plant Stems; Protective Agents; Pterocarpans | 2004 |
[Protective effect of the extract of Terminalia catappa leaves on acute liver injury induced by D-GalN in mice].
Topics: Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Female; Galactosamine; Liver; Male; Mice; Mice, Inbred ICR; Plant Leaves; Plants, Medicinal; Pregnancy; Protective Agents; Terminalia | 2004 |
Hepatoprotective activity of Adhatoda vasica aqueous leaf extract on D-galactosamine-induced liver damage in rats.
Topics: Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; Galactosamine; Justicia; Male; Phytotherapy; Plant Extracts; Plant Leaves; Protective Agents; Rats; Rats, Wistar | 2005 |
Effect of Tridax procumbens on liver antioxidant defense system during lipopolysaccharide-induced hepatitis in D-galactosamine sensitised rats.
Topics: Animals; Antioxidants; Asteraceae; Chemical and Drug Induced Liver Injury; Galactosamine; Glutathione Transferase; Lipid Peroxidation; Lipopolysaccharides; Liver; Male; Oxidative Stress; Oxidoreductases; Plant Extracts; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances | 2005 |
Hepatoprotective activity of aqueous-methanol extract of Artemisia vulgaris.
Topics: Animals; Artemisia; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Galactosamine; Humans; Infant; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Phytotherapy; Plant Components, Aerial; Plant Extracts; Protective Agents | 2005 |
A murine model of NKT cell-mediated liver injury induced by alpha-galactosylceramide/d-galactosamine.
Topics: Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Galactosamine; Galactosylceramides; In Situ Nick-End Labeling; Interferon-gamma; Killer Cells, Natural; Liver; Liver Diseases; Mice; Mice, Knockout; Receptors, Tumor Necrosis Factor; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha | 2005 |
Hepatoprotective activity of Tridax procumbens against d-galactosamine/lipopolysaccharide-induced hepatitis in rats.
Topics: Animals; Asteraceae; Chemical and Drug Induced Liver Injury; Galactosamine; India; Lipopolysaccharides; Liver; Male; Phytotherapy; Plant Extracts; Rats; Rats, Wistar | 2005 |
Protective effect of (S)-bakuchiol from Psoralea corylifolia on rat liver injury in vitro and in vivo.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Galactosamine; Liver; Male; Phenols; Phytotherapy; Plant Extracts; Protective Agents; Psoralea; Rats; Rats, Sprague-Dawley; Seeds; tert-Butylhydroperoxide | 2005 |
Chemistry and hepatoprotective activity of an active fraction from Barleria prionitis Linn. in experimental animals.
Topics: Acanthaceae; Acetaminophen; Administration, Oral; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; Galactosamine; Lethal Dose 50; Male; Mice; Phytotherapy; Plant Extracts; Plant Leaves; Plant Stems; Protective Agents; Rats | 2005 |
[Hepatoprotective effects of Gentiana scabra on the acute liver injuries in mice].
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Female; Galactosamine; Gentiana; Male; Mice; Plant Components, Aerial; Plant Roots; Plants, Medicinal; Random Allocation; Thioacetamide | 2005 |
Transgenic overexpression of interleukin-8 in mouse liver protects against galactosamine/endotoxin toxicity.
Topics: Animals; Apoptosis; Blotting, Western; Caspases; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Endotoxins; Enzyme-Linked Immunosorbent Assay; Galactosamine; Gene Expression; Interleukin-8; Liver; Liver Diseases; Male; Mice; Mice, Transgenic; NF-kappa B; RNA, Messenger; Transgenes; Tumor Necrosis Factor-alpha | 2006 |
Lack of protective effect of D-003, a mixture of high-molecular-weight primary acids from sugar cane wax, on liver damage induced by galactosamine in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Fatty Acids; Galactosamine; Hepatocytes; Inclusion Bodies; Lipids; Liver Diseases; Male; Necrosis; Rats; Rats, Sprague-Dawley | 2005 |
In vivo antihepatotoxic effects of Ligularia fischeri var. spiciformis and the identification of the active component, 3,4-dicaffeoylquinic acid.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Asteraceae; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlorogenic Acid; Ethionine; Fatty Liver; Galactosamine; gamma-Glutamyltransferase; L-Iditol 2-Dehydrogenase; L-Lactate Dehydrogenase; Lipids; Liver; Liver Diseases; Male; Plant Leaves; Rats; Rats, Sprague-Dawley | 2005 |
Green tea with a high catechin content suppresses inflammatory cytokine expression in the galactosamine-injured rat liver.
Topics: Animals; Catechin; Chemical and Drug Induced Liver Injury; Cytokines; Galactosamine; Humans; Liver; Male; Plant Extracts; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tea | 2005 |
Hepatoprotection of D-galactosamine-induced toxicity in mice by purified fractions from Garcinia kola seeds.
Topics: Animals; Chemical and Drug Induced Liver Injury; Flavonoids; Galactosamine; Garcinia kola; Glucose-6-Phosphatase; Glutathione; Lipid Peroxidation; Liver; Liver Diseases; Male; Mice; Microsomes, Liver; Protective Agents; Seeds; Transferases | 2006 |
Mechanism underlying mitochondrial protection of asiatic acid against hepatotoxicity in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Calcium; Chemical and Drug Induced Liver Injury; Cytochromes c; Galactosamine; Ion Channels; Lipopolysaccharides; Liver; Male; Membrane Potentials; Mice; Mice, Inbred ICR; Mitochondria, Liver; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Mitochondrial Swelling; Pentacyclic Triterpenes; RNA, Messenger; Triterpenes; Voltage-Dependent Anion Channels | 2006 |
Fructose 1,6-bisphosphate prevented endotoxemia, macrophage activation, and liver injury induced by D-galactosamine in rats.
Topics: Analysis of Variance; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Fructosediphosphates; Galactosamine; Hepatocytes; Histamine Release; Immunologic Factors; Inflammation; Kupffer Cells; Liver Failure, Acute; Macrophage Activation; Potassium Channels; Rats; Rats, Sprague-Dawley; Sepsis; Tumor Necrosis Factor-alpha | 2006 |
Y-40138, a multiple cytokine production modulator, protects against D-galactosamine and lipopolysaccharide-induced hepatitis.
Topics: Acetamides; Alanine Transaminase; Animals; Cell Death; Chemical and Drug Induced Liver Injury; Chemokine CCL2; Chemokines; Coculture Techniques; Cytokines; Female; Galactosamine; Hepatocytes; Lipopolysaccharides; Liver; Macrophages; Mice; Mice, Inbred BALB C; Piperazines; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2006 |
Hepatoprotective sesquiterpene glycosides from Sarcandra glabra.
Topics: Animals; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Galactosamine; Glycosides; Hepatocytes; Magnoliopsida; Molecular Structure; Plants, Medicinal; Rats; Sesquiterpenes | 2006 |
The model of D-galactosamine-induced injury of rat hepatocytes in primary culture.
Topics: Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Hepatocytes; Male; Rats; Rats, Wistar | 2006 |
Hepatoprotective effects of whey protein on D-galactosamine-induced hepatitis and liver fibrosis in rats.
Topics: Alanine; Animals; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Diet; Food, Formulated; Galactosamine; Hyaluronic Acid; L-Lactate Dehydrogenase; Liver Cirrhosis; Male; Milk Proteins; Protective Agents; Rats; Rats, Sprague-Dawley; Whey Proteins | 2006 |
Investigation of exenatide elimination and its in vivo and in vitro degradation.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Exenatide; Galactosamine; In Vitro Techniques; Kidney; Liver Cirrhosis; Male; Mass Spectrometry; Mice; Mice, Inbred Strains; Peptides; Rats; Rats, Sprague-Dawley; Thioacetamide; Venoms | 2006 |
Hepatoprotective effects of purple potato extract against D-galactosamine-induced liver injury in rats.
Topics: Animals; Appetite; Body Weight; Chemical and Drug Induced Liver Injury; Color; Galactosamine; Glutathione; Lipid Peroxidation; Liver; Liver Diseases; Male; Nitric Oxide; Organ Size; Plant Extracts; Rats; Solanum tuberosum; Thiobarbituric Acid Reactive Substances; Tumor Necrosis Factor-alpha | 2006 |
Protective effect of Lygodium flexuosum (L.) Sw. (Lygodiaceae) against D-galactosamine induced liver injury in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Female; Ferns; Galactosamine; Glutathione; Lipid Peroxidation; Liver; Male; Phytotherapy; Plant Preparations; Rats; Rats, Wistar | 2006 |
A metabonomics study of the hepatotoxicants galactosamine, methylene dianiline and clofibrate in rats.
Topics: Aniline Compounds; Animals; Chemical and Drug Induced Liver Injury; Clofibrate; Galactosamine; Liver; Liver Diseases; Metabolic Networks and Pathways; Rats; Urine | 2006 |
Red potato extract protects from D-galactosamine-induced liver injury in rats.
Topics: Alanine Transaminase; Animals; Anthocyanins; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Galactosamine; Glutathione; L-Lactate Dehydrogenase; Liver Diseases; Male; Plant Extracts; Random Allocation; Rats; Rats, Inbred F344; Solanum tuberosum; Thiobarbituric Acid Reactive Substances | 2006 |
Comprehensive analysis of differential gene expression profiles on D-galactosamine-induced acute mouse liver injury and regeneration.
Topics: Acute Disease; Animals; Cell Cycle; Chemical and Drug Induced Liver Injury; Galactosamine; Gene Expression; Gene Expression Profiling; Liver; Liver Regeneration; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2006 |
Carbon monoxide inhalation rescues mice from fulminant hepatitis through improving hepatic energy metabolism.
Topics: Animals; Antimetabolites; Apoptosis; Carbon Monoxide; Chemical and Drug Induced Liver Injury; Energy Metabolism; Galactosamine; Guanylate Cyclase; Heme Oxygenase-1; Liver; Liver Failure, Acute; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Tumor Necrosis Factor-alpha | 2007 |
Antioxidant and hepatoprotective actions of medicinal herb, Terminalia catappa L. from Okinawa Island and its tannin corilagin.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Free Radicals; Galactosamine; Glucosides; Hydrolyzable Tannins; Lipopolysaccharides; Liver; Male; Phytotherapy; Plant Extracts; Plant Leaves; Protective Agents; Rats; Rats, Sprague-Dawley; Tannins; Terminalia | 2007 |
Kava feeding in rats does not cause liver injury nor enhance galactosamine-induced hepatitis.
Topics: Acetone; Animals; Bile Acids and Salts; Biomarkers; Chemical and Drug Induced Liver Injury; Diet; Dose-Response Relationship, Drug; Drug Synergism; Ethanol; Galactosamine; Glucuronidase; Kava; L-Iditol 2-Dehydrogenase; Lipid Peroxides; Liver; Liver Function Tests; Male; Plant Extracts; Rats; Rats, Sprague-Dawley; Solvents | 2007 |
Xanthine oxidase-derived reactive oxygen species contribute to the development of D-galactosamine-induced liver injury in rats.
Topics: Alanine Transaminase; Allopurinol; Animals; Antioxidants; Ascorbic Acid; Aspartate Aminotransferases; Catalase; Chemical and Drug Induced Liver Injury; Galactosamine; Glutathione; Glutathione Peroxidase; Lipid Peroxidation; Liver; Male; Neutrophils; Peroxidase; Phospholipid Hydroperoxide Glutathione Peroxidase; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2007 |
Galactosamine-induced hepatotoxic effect and hepatoprotective role of a protein isolated from the herb Cajanus indicus L in vivo.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Biomarkers; Cajanus; Catalase; Chemical and Drug Induced Liver Injury; Galactosamine; Glutathione; Glutathione Reductase; Glutathione Transferase; Lipid Peroxidation; Liver; Mice; Plant Proteins; Protective Agents; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2007 |
The anti-fibrotic effect of green tea with a high catechin content in the galactosamine-injured rat liver.
Topics: Animals; Catechin; Chemical and Drug Induced Liver Injury; Fibrosis; Galactosamine; Liver; Rats; Tea | 2007 |
Hepatoprotective effects of a concentrate and components of sake against galactosamine (GalN)-induced liver injury in mice.
Topics: Alanine Transaminase; Alcoholic Beverages; Amino Acids; Animals; Aspartate Aminotransferases; Carbohydrates; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Galactosamine; Glucose; Glucosides; Interleukin-6; Male; Mice; Mice, Inbred BALB C | 2007 |
Hepatoprotective activity of the Leucas lavandulaefolia on D(+)galactosamine-induced hepatic injury in rats.
Topics: Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Lamiaceae; Male; Phytotherapy; Plant Extracts; Protective Agents; Rats; Rats, Wistar | 2007 |
Upregulation of heme oxygenase-1 with hemin prevents D-galactosamine and lipopolysaccharide-induced acute hepatic injury in rats.
Topics: Acute Disease; Animals; Apoptosis; Blotting, Western; Chemical and Drug Induced Liver Injury; Enzyme Induction; Galactosamine; Heme Oxygenase (Decyclizing); Hemin; Lipopolysaccharides; Liver; Male; Nitric Oxide; Rats; Rats, Sprague-Dawley; Up-Regulation | 2007 |
Melatonin attenuates lipopolysaccharide (LPS)-induced apoptotic liver damage in D-galactosamine-sensitized mice.
Topics: Alanine Transaminase; Animals; Antioxidants; Apoptosis; Caspase 3; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Drug Synergism; Female; Galactosamine; Glutathione; Lipopolysaccharides; Liver; Melatonin; Mice; Mice, Inbred Strains; Nitric Oxide; Tumor Necrosis Factor-alpha | 2007 |
Bioactive constituents from Chinese natural medicines. XXIII. Absolute structures of new megastigmane glycosides, sedumosides A(4), A(5), A(6), H, and I, and hepatoprotective megastigmanes from Sedum sarmentosum.
Topics: Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Cyclohexanones; Galactosamine; Glucosamine; Glucosides; Glycosides; Hepatocytes; Hydrolysis; Magnetic Resonance Spectroscopy; Mice; Norisoprenoids; Sedum; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Stereoisomerism | 2007 |
Effect of angiotensin AT1 receptor antagonist on D-galactosamine-induced acute liver injury.
Topics: Acute Disease; Alanine Transaminase; Angiotensin II Type 1 Receptor Blockers; Animals; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Immunohistochemistry; Liver; Losartan; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; Survival; Tissue Inhibitor of Metalloproteinase-1 | 2007 |
Inhibitory effect of glycyrrhizin on lipopolysaccharide and d-galactosamine-induced mouse liver injury.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cytokines; Galactosamine; Glycyrrhizic Acid; Lipopolysaccharides; Liver Diseases; Male; Mice; Mice, Inbred BALB C; Protective Agents | 2007 |
Methylprednisolone injection via the portal vein suppresses inflammation in acute liver failure induced in rats by lipopolysaccharide and d-galactosamine.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Injections, Intravenous; Interferon-gamma; Lipopolysaccharides; Liver Failure, Acute; Male; Methylprednisolone Hemisuccinate; Portal Vein; Rats; Rats, Wistar; Survival Rate; Tumor Necrosis Factor-alpha | 2007 |
Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium.
Topics: Acetylglucosamine; Animals; Biomarkers; Cell Adhesion Molecules; Chemical and Drug Induced Liver Injury; Chromium; Dose-Response Relationship, Drug; Galactosamine; Gene Expression; Gentamicins; Immunohistochemistry; Kidney; Kidney Diseases; Kidney Function Tests; Male; Membrane Proteins; Mercury; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA | 2008 |
Effects of various kinds of edible seaweeds in diets on the development of D-galactosamine-induced hepatopathy in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Carboxylic Acids; Cecum; Chemical and Drug Induced Liver Injury; Dietary Fiber; Galactosamine; Glutathione; Hydro-Lyases; Liver Diseases; Male; Rats; Rats, Wistar; Seaweed | 2007 |
Galactosamine-induced acute liver injury in rats reduces hepatic alpha-tocopherol transfer protein production.
Topics: Alanine Transaminase; alpha-Tocopherol; Animals; Aspartate Aminotransferases; Blotting, Western; Carrier Proteins; Chemical and Drug Induced Liver Injury; Cholesterol; Disease Models, Animal; Galactosamine; L-Lactate Dehydrogenase; Liver Diseases; Male; Phospholipids; Random Allocation; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Triglycerides | 2007 |
N-acetylcysteine attenuates lipopolysaccharide-induced apoptotic liver damage in D-galactosamine-sensitized mice.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Galactosamine; Lipopolysaccharides; Mice; Mice, Inbred Strains; Nitric Oxide; Tumor Necrosis Factor-alpha | 2007 |
Effect of dietary fiber in edible seaweeds on the development of D-galactosamine-induced hepatopathy in rats.
Topics: Alanine Transaminase; Animals; Anti-Bacterial Agents; Aspartate Aminotransferases; Body Weight; Cecum; Chemical and Drug Induced Liver Injury; Dietary Fiber; Disease Models, Animal; Galactosamine; Intestines; L-Lactate Dehydrogenase; Liver; Liver Diseases; Male; Neomycin; Rats; Rats, Wistar; Seaweed | 2007 |
Hepatoprotective potential of Fumaria indica Pugsley whole plant extracts, fractions and an isolated alkaloid protopine.
Topics: Animals; Benzophenanthridines; Berberine Alkaloids; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Fumaria; Galactosamine; Liver; Male; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley | 2008 |
Significantly greater antioxidant anticancer activities of 2,3-dehydrosilybin than silybin.
Topics: Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Cell Cycle; Cell Line; Cell Line, Tumor; Cell Movement; Cell Survival; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Galactosamine; Hepatocytes; Humans; Hydrogen Peroxide; Keratinocytes; Liver Diseases; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Molecular Structure; Reactive Oxygen Species; Silybin; Silymarin | 2008 |
Preventive effect of ethanol extract of Phyllanthus rheedii Wight. on D-galactosamine induced hepatic damage in Wistar rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Ethanol; Female; Galactosamine; Gene Expression Regulation; Liver; Liver Diseases; Male; Phyllanthus; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2008 |
Glycyrrhizin prevents of lipopolysaccharide/D-galactosamine-induced liver injury through down-regulation of matrix metalloproteinase-9 in mice.
Topics: Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Down-Regulation; Galactosamine; Glycyrrhizic Acid; Immunohistochemistry; Injections, Intraperitoneal; Injections, Intravenous; Lipopolysaccharides; Liver; Liver Diseases; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation | 2008 |
Superiority of serum type-I arginase and ornithine carbamyltransferase in the detection of toxicant-induced acute hepatic injury in rats.
Topics: Alanine Transaminase; Animals; Arginase; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Concanavalin A; Galactosamine; Lipopolysaccharides; Liver Diseases; Liver Function Tests; Male; Ornithine Carbamoyltransferase; Propanols; Rats; Rats, Wistar | 2008 |
Tumor necrosis factor alpha mediates the lethal hepatotoxic effects of poly(I:C) in D-galactosamine-sensitized mice.
Topics: Animals; Antibodies; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Humans; Hypothermia; Interferon Inducers; Lipopolysaccharides; Liver; Liver Failure; Mice; Mice, Inbred C57BL; Mice, Knockout; Poly I-C; Receptors, Tumor Necrosis Factor, Type I; Survival Rate; Toll-Like Receptors; Tumor Necrosis Factor Decoy Receptors; Tumor Necrosis Factor-alpha | 2008 |
Protective effects of pirfenidone on D-galactosamine and lipopolysaccharide-induced acute hepatotoxicity in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Galactosamine; Inflammation; Lipid Peroxidation; Lipopolysaccharides; Liver; Liver Diseases; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Pyridones; Rats; Rats, Sprague-Dawley; Severity of Illness Index | 2008 |
Sialoadenectomy enhances hepatic injury induced by lipopolysaccharide/galactosamine in mice.
Topics: Adrenal Glands; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Corticosterone; Disease Models, Animal; Drug Therapy, Combination; Galactosamine; Hepatocytes; Interleukin-6; Lipopolysaccharides; Liver; Male; Mice; Perfusion; Peroxidase; Submandibular Gland; Tumor Necrosis Factor-alpha | 2008 |
A diterpenoid acanthoic acid from Acanthopanax koreanum protects against D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure in mice.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Diterpenes; DNA Fragmentation; Eleutherococcus; Galactosamine; In Situ Nick-End Labeling; Lipopolysaccharides; Liver Failure, Acute; Male; Mice; Mice, Inbred C57BL; Plant Roots; Tumor Necrosis Factor-alpha | 2008 |
Pectolinarin and Pectolinarigenin of Cirsium setidens Prevent the Hepatic Injury in Rats Caused by D-Galactosamine via an Antioxidant Mechanism.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Chromones; Cirsium; Galactosamine; Liver Function Tests; Magnetic Resonance Spectroscopy; Male; Plant Extracts; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2008 |
Combination of selenium and three naturally occurring antioxidants administration protects D-galactosamine-induced liver injury in rats.
Topics: alpha-Tocopherol; Animals; Antioxidants; Apoptosis; Ascorbic Acid; beta Carotene; Caspase 3; Cell Proliferation; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Female; Galactosamine; Immunohistochemistry; In Situ Nick-End Labeling; Liver; Liver Diseases; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Selenium | 2008 |
Hepatoprotective effects of Ganoderma lucidum peptides against D-galactosamine-induced liver injury in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Glutathione; Liver; Liver Function Tests; Male; Malondialdehyde; Mice; Protective Agents; Reishi; Superoxide Dismutase | 2008 |
Cytochrome c: a non-invasive biomarker of drug-induced liver injury.
Topics: Acetaminophen; Acute Disease; Animals; Apoptosis; Biomarkers; Chemical and Drug Induced Liver Injury; Cytochromes c; Disease Models, Animal; Dose-Response Relationship, Drug; Galactosamine; Hepatocytes; Male; Mitochondria; Necrosis; Rats; Rats, Sprague-Dawley | 2008 |
Protective effect of baicalin against lipopolysaccharide/D-galactosamine-induced liver injury in mice by up-regulation of heme oxygenase-1.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Chemical and Drug Induced Liver Injury; Flavonoids; Galactosamine; Heme Oxygenase-1; Lipopolysaccharides; Liver; Mice; Mice, Inbred BALB C; Peroxidase; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha; Up-Regulation | 2008 |
Protective properties of Leucas lavendulaefolia extracts against D-galactosamine induced hepatotoxicity in rat.
Topics: Animals; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Lamiaceae; Male; Plant Extracts; Rats; Rats, Wistar | 2008 |
New hepatoprotective coumarinolignoids from Mallotus apelta.
Topics: Animals; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Coumarins; Galactosamine; Hepatocytes; Mallotus Plant; Nuclear Magnetic Resonance, Biomolecular; Plant Roots; Rats | 2008 |
Enhanced susceptibility to Con A-induced liver injury in mice transgenic for the intracellular isoform of human TNF receptor type 2.
Topics: Animals; Cell Death; Cell Line; Chemical and Drug Induced Liver Injury; Concanavalin A; Disease Susceptibility; Galactosamine; Humans; Intracellular Space; Lipopolysaccharides; Liver Diseases; Mice; Mice, Transgenic; Neutralization Tests; Protein Isoforms; Receptors, Tumor Necrosis Factor, Type II; Solubility; Tumor Necrosis Factor-alpha | 2008 |
Protective role of metallothionein in coagulatory disturbance accompanied by acute liver injury induced by LPS/D-GalN.
Topics: Animals; Blood Coagulation; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Disseminated Intravascular Coagulation; Fibrinogen; Galactosamine; Lipopolysaccharides; Liver; Liver Diseases; Metallothionein; Mice; Mice, Inbred C57BL; Mice, Knockout; Platelet Count; Time Factors | 2008 |
Walnut polyphenols prevent liver damage induced by carbon tetrachloride and d-galactosamine: hepatoprotective hydrolyzable tannins in the kernel pellicles of walnut.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Flavonoids; Galactosamine; Gallic Acid; Glucosides; Hydrolysis; Juglans; Liver Diseases; Phenols; Polyphenols; Rats; Seeds; Tannins | 2008 |
D-galactosamine-induced liver injury in immunosuppressed mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Immunosuppression Therapy; Inclusion Bodies; Leukocyte Count; Liver; Liver Regeneration; Male; Mice; Mice, Inbred DBA; Microscopy, Electron; Necrosis; Thymectomy; Whole-Body Irradiation | 1984 |
The pattern of D-galactosamine-induced hepatocellular injury modified by simultaneous application of D (--)-fructose.
Topics: Animals; Chemical and Drug Induced Liver Injury; Fructose; Galactosamine; Liver; Liver Diseases; Male; Microscopy, Electron; Rats; Rats, Inbred Strains; Time Factors | 1981 |
Beneficial effect of somatostatin on galactosamine induced liver injury.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Male; Rats; Somatostatin | 1983 |
Preventive effects of 5-fluorouridine and uridine on d-galactosamine-induced liver injury.
Topics: Animals; Cell Nucleolus; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Liver; Rats; RNA; Uridine; Uridine Diphosphate; Uridine Diphosphate Glucose; Uridine Diphosphate Sugars; Uridine Triphosphate | 1981 |
Studies on severe hepatic damage induced by galactosamine.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; DNA; Galactosamine; Liver; Male; Necrosis; Rats; Rats, Inbred Strains; RNA; Uridine Diphosphate Glucose; Uridine Triphosphate | 1982 |
[Protective and curative effects of diethyldithiocarbamate on galactosamine hepatitis in the rat (author's transl)].
Topics: Animals; Chemical and Drug Induced Liver Injury; Ditiocarb; Enzymes; Galactosamine; Male; Rats; Thiocarbamates | 1980 |
[Experimental and clinical studies on enzymes of mitochondria in various liver diseases; with special reference to alcoholic liver disease (author's transl)].
Topics: 1-Naphthylisothiocyanate; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Galactosamine; Glucose-6-Phosphatase; Glucosephosphate Dehydrogenase; Humans; Liver Diseases, Alcoholic; Male; Mitochondria, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Ornithine Carbamoyltransferase; Rats; Sodium-Potassium-Exchanging ATPase; Succinate Cytochrome c Oxidoreductase | 1980 |
The role of calcium in liver cell damage. Comparative studies with carbon tetrachloride and D-galactosamine.
Topics: Alanine Transaminase; Animals; Calcium; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cholecalciferol; Female; Galactosamine; L-Iditol 2-Dehydrogenase; L-Lactate Dehydrogenase; Liver; Potassium; Rats | 1980 |
Influence of D-galactosamine upon the NAD-metabolism in rat liver.
Topics: Adrenalectomy; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Methionine; NAD; Niacinamide; Nucleotidyltransferases; Poly(ADP-ribose) Polymerases; Rats; Rats, Inbred Strains; Tryptophan | 1983 |
Effects of intrasplenic injection of hepatocytes, hepatocyte fragments and hepatocyte culture supernatants on D-galactosamine-induced liver failure in rats.
Topics: Acute Disease; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Galactosamine; In Vitro Techniques; Liver; Liver Diseases; Liver Transplantation; Male; Rats; Rats, Inbred F344; Spleen; Transplantation, Isogeneic | 1983 |
Zinc content in liver of experimental fulminant hepatic failure rat.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Glucagon; Insulin; Liver Diseases; Liver Regeneration; Male; Rats; Rats, Inbred Strains; Zinc | 1983 |
The mechanism of hepatoprotection by epsilon aminocaproic acid and putrescine.
Topics: Aminocaproates; Aminocaproic Acid; Animals; Chemical and Drug Induced Liver Injury; Eflornithine; Galactosamine; Liver Diseases; Necrosis; Ornithine; Ornithine Decarboxylase Inhibitors; Protease Inhibitors; Putrescine; Rats; Rats, Inbred Strains; Urokinase-Type Plasminogen Activator | 1984 |
The influence of nicotinamide, tryptophan, and methionine upon galactosamine-induced effects in the liver.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Interactions; Female; Galactosamine; Liver; Male; Methionine; Niacinamide; Prednisolone; Rats; Tryptophan | 1981 |
Synthesis of hepatic glycosaminoglycans in the early stages of galactosamine hepatitis: a rapid decline of heparan sulfate is followed by elevation of chondroitin sulfate and dermatan sulfate.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chondroitin; Chondroitin Sulfates; Dermatan Sulfate; Galactosamine; Glycosaminoglycans; Heparitin Sulfate; Hepatectomy; Liver; Liver Regeneration; Male; Polysaccharides; Rats | 1981 |
The metabolism and excretion of [14C]imipramine in an experimental hepatitis.
Topics: Animals; Bile; Chemical and Drug Induced Liver Injury; Galactosamine; Hepatitis, Animal; Imipramine; Male; Rats; Rats, Inbred Strains | 1984 |
Synthesis of LDL-apoproteins in D-galactosamine-induced hepatitis in rats.
Topics: Animals; Apolipoproteins; Chemical and Drug Induced Liver Injury; Galactosamine; Hepatitis; Lipoproteins, LDL; Rats; Rats, Inbred Strains | 1984 |
[Pharmacological studies on saiko-prescriptions. VI. Effect of shosaiko-to on liver injury induced by D-galactosamine in rats].
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Galactosamine; Male; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Plants, Medicinal; Rats; Rats, Inbred Strains | 1984 |
Efficacies of whole blood and plasma cross circulation on galactosamine induced hepatic failure rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cross Circulation; Galactosamine; Liver Diseases; Liver Function Tests; Male; Parabiosis; Plasma; Rats; Rats, Inbred Strains | 1984 |
[Alterations in hepatic high-energy metabolism in galactosamine-induced acute hepatic failure in rabbits].
Topics: Acute Disease; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Chemical and Drug Induced Liver Injury; Energy Metabolism; Galactosamine; Liver; Liver Diseases; Mitochondria, Liver; Rabbits | 1984 |
Effect of aging on liver glutathione levels and hepatocellular injury from carbon tetrachloride, allyl alcohol or galactosamine.
Topics: 1-Propanol; Aging; Alanine Transaminase; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Galactosamine; Glutathione; Liver; Male; Propanols; Rats; Rats, Inbred F344; Sulfhydryl Compounds | 1984 |
[Effect of antithrombin III on experimental hepatotoxin poisoning in dogs].
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antithrombin III; Aspartate Aminotransferases; Bilirubin; Blood Glucose; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Dogs; Female; Galactosamine; Male; Platelet Count | 1984 |
Altered thiamine propyl disulfide metabolism in rats with liver injury induced by carbon tetrachloride and D-galactosamine.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Galactosamine; Male; Microsomes, Liver; Rats; Rats, Inbred Strains; Thiamine; Time Factors | 1983 |
Activation of tubuloglomerular feedback in rat nephrons by sera from rabbits with fulminant hepatic failure.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dialysis; Feedback; Female; Galactosamine; Glomerular Filtration Rate; Kidney Glomerulus; Kidney Tubules; Liver Diseases; Male; Perfusion; Rabbits; Rats; Rats, Inbred Strains | 1983 |
Intestinal lipoproteins in the rat with D-(+)-galactosamine hepatitis.
Topics: Animals; Apolipoproteins; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Intestinal Absorption; Intestines; Lecithin Cholesterol Acyltransferase Deficiency; Lipids; Lipoproteins; Lymph; Microscopy, Electron; Rats; Rats, Inbred Strains; Triolein | 1983 |
[Morphological characteristics of D-galactosamine hepatitis].
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Male; Microscopy, Electron; Necrosis; Rats; Rats, Inbred Strains; Time Factors | 1983 |
Analysis of hepatic failure plasma by high performance gel-chromatography.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chromatography, Gel; Dogs; Galactosamine; Liver Diseases; Male; Molecular Weight; Rats; Rats, Inbred Strains | 1983 |
Effect of chronic ethanol ingestion on liver and plasma protein synthesis in galactosamine-induced hepatitis in rats.
Topics: Alcoholism; Animals; Blood Proteins; Chemical and Drug Induced Liver Injury; Galactosamine; Humans; Kinetics; Liver; Male; Propylthiouracil; Protein Biosynthesis; Rats; Rats, Inbred Strains | 1983 |
Influence of aging on the susceptibility of rats to hepatotoxic injury.
Topics: 1-Propanol; Aging; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bromobenzenes; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Endoplasmic Reticulum; Galactosamine; Liver; Male; NADH Dehydrogenase; Necrosis; Propanols; Rats; Rats, Inbred F344 | 1984 |
Cystamine modulation of galactosamine-induced hepatotoxicity.
Topics: Animals; Calcium; Chemical and Drug Induced Liver Injury; Cystamine; Dose-Response Relationship, Drug; Galactosamine; Liver; Liver Diseases; Male; Necrosis; Rats; Rats, Inbred Strains; Uridine | 1984 |
Effects of homologous plasma cross-circulation on liver function in galactosamine-induced hepatic necrosis in rats.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cross Circulation; Galactosamine; Liver Diseases; Liver Function Tests; Male; Mitochondria, Liver; Necrosis; Parabiosis; Plasma Exchange; Rats; Rats, Inbred Strains | 1984 |
[Long-term cross-circulation on galactosamine induced hepatic failure rats].
Topics: Animals; Chemical and Drug Induced Liver Injury; Cross Circulation; Galactosamine; Liver Diseases; Liver Regeneration; Male; Mitochondria, Liver; Parabiosis; Rats; Rats, Inbred Strains | 1984 |
[Homologous plasma cross-circulation on galactosamine induced hepatic failure rats].
Topics: Animals; Chemical and Drug Induced Liver Injury; Cross Circulation; Galactosamine; Liver Diseases; Male; Parabiosis; Plasmapheresis; Rats; Rats, Inbred Strains | 1984 |
Tyrosinase immobilized within artificial cells for detoxification in liver failure: II. In vivo studies in fulminant hepatic failure rats.
Topics: Animals; Catechol Oxidase; Chemical and Drug Induced Liver Injury; Enzymes, Immobilized; Galactosamine; Hemoperfusion; Inactivation, Metabolic; Liver Diseases; Male; Monophenol Monooxygenase; Rats; Rats, Inbred Strains; Tyrosine | 1981 |
[Preliminary observations on D-galactosamine-induced hepatic failure in rat models (author's transl)].
Topics: Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Liver; Liver Diseases; Rats | 1981 |
The protective effect of polyriboinosinic acid-polyribocytidylic acid against the occurrence of galactosamine-induced liver cell injury in rat.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carboxymethylcellulose Sodium; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Liver Diseases; Male; Methylcellulose; Necrosis; Peptides; Poly I-C; Polylysine; Rats; Rats, Inbred Strains | 1983 |
Increased blood-brain transfer in a rabbit model of acute liver failure.
Topics: Aminoisobutyric Acids; Animals; Autoradiography; Biological Transport, Active; Blood-Brain Barrier; Capillary Permeability; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; Galactosamine; Hepatic Encephalopathy; Liver Diseases; Rabbits | 1983 |
Modulation of galactosamine-induced liver injury by some amino acids or Triton WR1339.
Topics: Amino Acids; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Isocitrate Dehydrogenase; Liver Diseases; Male; Necrosis; Polyethylene Glycols; Rats; Rats, Inbred Strains | 1983 |
Potentiation of hepatotoxicity by ethanol in galactosamine-induced hepatitis in rats: role of propylthiouracil protection.
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Synergism; Ethanol; Galactosamine; Liver Function Tests; Male; Propylthiouracil; Rats; Rats, Inbred Strains | 1983 |
Sensitivity of serum glutamic oxaloacetic transaminase and bile acid levels for the detection of experimental liver injury in rats.
Topics: Animals; Aspartate Aminotransferases; Bile Acids and Salts; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Disease Models, Animal; Galactosamine; Liver Diseases; Male; Rats; Rats, Inbred Strains | 1981 |
Enhanced D-galactosamine hepatotoxicity after propylthiouracil treatment in the rat.
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Synergism; Female; Galactosamine; Liver; Propylthiouracil; Rats; Rats, Inbred Strains | 1982 |
Reversal of toxic and anoxic induced hepatic failure by syngeneic, allogeneic, and xenogeneic hepatocyte transplantation.
Topics: Animals; Antibody-Dependent Cell Cytotoxicity; Chemical and Drug Induced Liver Injury; Galactosamine; Hepatic Artery; Ligation; Liver; Liver Diseases; Liver Transplantation; Male; Peritoneal Cavity; Rats; Rats, Inbred Lew; Swine; Tissue Preservation; Transplantation, Heterologous; Transplantation, Homologous; Transplantation, Isogeneic | 1980 |
Reversal of experimental acute hepatic failure in the rat.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Galactosamine; Liver; Liver Diseases; Liver Transplantation; Male; Rats; Rats, Inbred F344; Rats, Inbred Lew; Transplantation, Homologous; Transplantation, Isogeneic | 1980 |
Studies into the mechanism of reversal of experimental acute hepatic failure by hepatocyte transplantation. 1.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytosol; Female; Galactosamine; Graft Enhancement, Immunologic; Liver; Liver Diseases; Liver Regeneration; Liver Transplantation; Male; Rabbits; Rats; Swine; Thymidine; Transplantation, Heterologous; Transplantation, Homologous; Tritium | 1981 |
Lactulose--a drug with antiendotoxin effect.
Topics: Animals; Antitoxins; Chemical and Drug Induced Liver Injury; Culture Techniques; Disaccharides; Endotoxins; Escherichia coli; Galactosamine; Lactulose; Limulus Test; Liver; Liver Cirrhosis; Rats; Toxemia | 1980 |
Detection of liver IgG Fc receptors using soluble immune complexes of peroxidase-antiperoxidase. II. Detection in liver tissue from mice with D-galactosamine-induced hepatitis.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Hepatitis, Animal; Immunoenzyme Techniques; Liver; Mice; Receptors, Fc | 1981 |
Insulin and glucagon concentrations in the portal and peripheral blood in liver-injured and partially hepatectomized rats.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Galactosamine; Glucagon; Hepatectomy; Insulin; Jugular Veins; Liver Diseases; Liver Regeneration; Male; Portal Vein; Rats; Rats, Inbred Strains | 1982 |
The sequence of changes in the biosynthesis of sulfated glycosaminoglycans in acute, experimental liver disease.
Topics: Animals; Chemical and Drug Induced Liver Injury; Enzymes; Galactosamine; Glycosaminoglycans; Glycosides; Liver Cirrhosis, Experimental; Liver Diseases; Male; Phosphoadenosine Phosphosulfate; Protein Biosynthesis; Rats; Rats, Inbred Strains; Thioacetamide | 1982 |
Cell-free supernatant from hepatocyte cultures improves survival of rats with chemically induced acute liver failure.
Topics: Acute Disease; Animals; Cell Extracts; Cells, Cultured; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Liver Diseases; Male; Microscopy, Electron; Rats; Rats, Inbred F344; Tissue Extracts | 1982 |
Lipoprotein lipase and hepatic lipase deficiencies associated with impaired chylomicron clearance in D-(+) galactosamine hepatitis.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chylomicrons; Dietary Fats; Fasting; Female; Galactosamine; Lipase; Lipoprotein Lipase; Lipoproteins; Liver; Rats; Rats, Inbred Strains | 1982 |
Dissociation between renal gluconeogenesis and ammoniagenesis after acute liver intoxication.
Topics: Acidosis; Ammonia; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Gluconeogenesis; Kidney; Kidney Cortex; Phosphoenolpyruvate Carboxykinase (GTP); Rats; Rats, Inbred Strains | 1982 |
[Modelling of acute liver failure in rabbits].
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Liver; Liver Diseases; Rabbits; Time Factors | 1982 |
Alterations in lipoprotein composition associated with galactosamine-induced rat liver injury.
Topics: Animals; Apolipoproteins; Centrifugation, Density Gradient; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Hepatitis; Hypolipoproteinemias; Lecithin Cholesterol Acyltransferase Deficiency; Lipids; Lipoproteins; Liver; Microscopy, Electron; Phosphatidylcholine-Sterol O-Acyltransferase; Rats; Rats, Inbred Strains; Ultracentrifugation | 1982 |
Biochemical markers in carbon-tetrachloride-and galactosamine-induced acute liver injuries: the effects of dihydroquinoline-type antioxidants.
Topics: Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Fatty Liver; Galactosamine; Inflammation; Liver; Malondialdehyde; Mice; Quinolines | 1982 |
Liver-protective actions of desoxypodophyllotoxin and its analogs.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Galactosamine; Liver; Male; Mice; Podophyllotoxin; Structure-Activity Relationship | 1982 |
Protective action of desoxypodophyllotoxin on D-galactosamine-induced liver lesion in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Galactosamine; Male; Podophyllotoxin; Rats; Rats, Inbred Strains | 1982 |
Trimethadione as a model drug for the evaluation of hepatic drug-metabolizing capacity in normal and D-galactosamine intoxicated rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochromes; Dimethadione; Galactosamine; Kinetics; Liver; Male; Oxazoles; Rats; Rats, Inbred Strains; Trimethadione | 1982 |
Effects of vitamin E on D-galactosamine-induced or carbon tetrachloride-induced hepatotoxicity.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Liver; Lysosomes; Rats; Rats, Inbred Strains; Thiobarbiturates; Vitamin E | 1982 |
Effect of acute and chronic ethanol intoxication on hepatic regeneration.
Topics: Alcoholic Intoxication; Alcoholism; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Diet; Ethanol; Female; Galactosamine; Humans; Liver Regeneration; Rats; Thymidine | 1980 |
Cytoprotective effect of 16, 16' dimethyl prostaglandin E2 and some drugs on an acute galactosamine induced liver damage in rat.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Chemical and Drug Induced Liver Injury; Choline; Drug Combinations; Galactosamine; Liver; Liver Cirrhosis; Male; Orotic Acid; Premedication; Prostaglandins E, Synthetic; Rats | 1980 |
[Gamma-emitter labelled amino sugars: organ distribution and metabolism of 103Ru-ruthenocene derivatives in mice].
Topics: Amino Sugars; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Gamma Rays; Glucosamine; Mannose; Mice; Radioisotopes; Radionuclide Imaging; Ruthenium; Tissue Distribution | 1981 |
Pathological study of chronic D-galactosamine induced hepatitis in mice by administration of adjuvants - an animal model of the chronic active hepatitis.
Topics: Adjuvants, Immunologic; Animals; Blood Proteins; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Liver; Mice; Mice, Inbred C57BL; Necrosis; Organ Size; Spleen | 1981 |
Decrease of a hepatic binding protein specific for asialoglycoproteins with accumulation of serum asialoglycoproteins in galactosamine-treated rats.
Topics: Animals; Asialoglycoproteins; Carrier Proteins; Chemical and Drug Induced Liver Injury; Galactosamine; Glycoproteins; Lectins; Liver Diseases; Male; Microsomes, Liver; Orosomucoid; Rats; Receptors, Cell Surface | 1981 |
Decreased carbohydrate content of rat plasma apolipoproteins in galactosamine hepatitis.
Topics: Acetylglucosamine; Animals; Apolipoproteins; Carbohydrates; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Galactose; Hepatitis; Kinetics; Mannose; Rats; Rats, Inbred Strains | 1981 |
Raised serum biliverdin in hepatic necrosis.
Topics: Acetaminophen; Animals; Bile Acids and Salts; Bilirubin; Biliverdine; Chemical and Drug Induced Liver Injury; Cholestasis; Galactosamine; Humans; Liver; Liver Diseases; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Rats | 1981 |
Pharmacokinetic studies of trimethadione and its metabolite in rats with chemical-induced liver injury.
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Biotransformation; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Dimethadione; Galactosamine; Injections, Intravenous; Kinetics; Male; Oxazoles; Rats; Time Factors; Trimethadione | 1981 |
Selective uptake of liposomes by different cell types of liver through the involvement of liposomal surface glycosides.
Topics: Animals; Biological Transport; Chemical and Drug Induced Liver Injury; Galactosamine; Liposomes; Liver; Liver Glycogen; Rats; Uridine | 1981 |
Treatment of endotoxemia in galactosamine hepatitis by lactulose administered intravenously.
Topics: Animals; Chemical and Drug Induced Liver Injury; Disaccharides; Endotoxins; Galactosamine; Infusions, Parenteral; Lactulose; Liver; Liver Diseases; Rats | 1981 |
Rat liver storage iron and plasma ferritin during D-galactosamine-HCl-induced hepatitis.
Topics: Animals; Chemical and Drug Induced Liver Injury; Ferritins; Galactosamine; Hydrochloric Acid; Iron; Liver; Male; Rats | 1980 |
Protective effect of (+)cyanidanol-3 in acute liver injury induced by galactosamine or carbon tetrachloride in the rat.
Topics: Animals; Benzopyrans; Carbon Tetrachloride Poisoning; Catechin; Chemical and Drug Induced Liver Injury; Galactosamine; Lipid Peroxides; Liver Function Tests; Male; Rats; Time Factors | 1980 |
[Lidocain clearance after oral and intravenous application in rats with low grade ANIT-cholestasis and galactosamine-induced hepatitis (author's transl)].
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Biological Availability; Chemical and Drug Induced Liver Injury; Cholestasis; Galactosamine; Hepatitis; Injections, Intravenous; Lidocaine; Liver; Male; Rats | 1980 |
Interleukin-1 and nitric oxide protect against tumor necrosis factor alpha-induced liver injury through distinct pathways.
Topics: Animals; Apoptosis; Chemical and Drug Induced Liver Injury; DNA; Drug Tolerance; Galactosamine; Humans; Interleukin-1; Liver; Liver Diseases; Male; Mice; Mice, Inbred BALB C; Necrosis; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Nitroprusside; Recombinant Proteins; Tumor Necrosis Factor-alpha | 1995 |
[Liver-protecting and alanine aminotransferase lowering actions of hongning gantai].
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Drug Combinations; Drugs, Chinese Herbal; Female; Galactosamine; Liver; Liver Diseases; Male; Mice; Rats; Rats, Sprague-Dawley | 1995 |
Activation, proliferation, and differentiation of progenitor cells into hepatocytes in the D-galactosamine model of liver regeneration.
Topics: Albumins; alpha-Fetoproteins; Animals; Cell Differentiation; Cell Division; Chemical and Drug Induced Liver Injury; DNA; Galactosamine; gamma-Glutamyltransferase; Glucose-6-Phosphatase; Histocytochemistry; In Situ Hybridization; Liver; Liver Regeneration; Male; Models, Biological; Rats; Rats, Inbred F344; Rats, Inbred Lew; RNA, Messenger; Stem Cells; Thymidine; Time Factors; Tritium | 1993 |
Role of acute-phase proteins in interleukin-1-induced nonspecific resistance to bacterial infections in mice.
Topics: Acute-Phase Proteins; Animals; Blood Glucose; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; Fibrinogen; Galactosamine; Homeostasis; Immunity, Innate; Interleukin-1; Interleukin-6; Klebsiella Infections; Klebsiella pneumoniae; Liver Diseases; Mice; Pseudomonas Infections | 1993 |
Body composition in immature rats with D-galactosamine induced hepatitis and bile duct ligation.
Topics: Animals; Bile Ducts; Body Composition; Body Weight; Chemical and Drug Induced Liver Injury; Galactosamine; Heart; Liver; Male; Muscle, Skeletal; Organ Size; Proteins; Rats; Rats, Wistar; Reference Values; RNA | 1994 |
Synthesis and pharmacological activities of novel bicyclic thiazoline derivatives as hepatoprotective agents II. (7-Alkoxycarbonyl-2,3,5,6-tetrahydropyrrolo[2,1-b]thiazol-3-ylidend) acetamid derivatives.
Topics: Animals; Antibodies, Monoclonal; Bridged Bicyclo Compounds; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Liver Diseases; Mice; Rats; Structure-Activity Relationship; Thiazoles | 1995 |
Relationship between naproxen plasma concentration and its anti-inflammatory effect in experimental hepatitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemical and Drug Induced Liver Injury; Enzymes; Fever; Galactosamine; Half-Life; Liver Function Tests; Male; Naproxen; Rats; Rats, Wistar | 1995 |
Preventive effect of taraxasteryl acetate from Inula britannica subsp. japonica on experimental hepatitis in vivo.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Galactosamine; Inula; Liver Failure; Male; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Sterols; Triterpenes | 1995 |
The evaluation of hepatoprotective effects of Taiwan folk medicine 'teng-khia-u'.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Cell Division; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Liver; Liver Diseases; Lymphocytes; Male; Medicine, Traditional; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Taiwan | 1995 |
Arachidonic acid metabolism in galactosamine/endotoxin induced acute liver injury in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acids; Chemical and Drug Induced Liver Injury; Endotoxins; Galactosamine; Liver; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Thromboxane B2 | 1994 |
Serum release of hepatic calcium-binding protein regucalcin by liver injury with galactosamine administration in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Calcium; Calcium-Binding Proteins; Carboxylic Ester Hydrolases; Chemical and Drug Induced Liver Injury; Enzyme-Linked Immunosorbent Assay; Galactosamine; Intracellular Signaling Peptides and Proteins; Liver; Male; Rats; Rats, Wistar; Sulfotransferases | 1994 |
Effect of pretreatment of rats with uracil on liver injuries induced by D-galactosamine and allyl alcohol.
Topics: 1-Propanol; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Liver Diseases; Male; Propanols; Rats; Rats, Wistar; Uracil | 1994 |
Role of polymorphonuclear leukocytes in galactosamine hepatitis: mechanism of adherence to hepatic endothelial cells.
Topics: Alprostadil; Animals; Cell Adhesion; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chi-Square Distribution; Dinoprostone; Endothelium; Galactosamine; Intercellular Adhesion Molecule-1; Lipopolysaccharides; Liver; Male; Neutrophil Activation; Neutrophils; Rats; Superoxide Dismutase; Superoxides; Tumor Necrosis Factor-alpha | 1994 |
Effects of mild zinc deficiency, plus or minus an acute-phase response, on galactosamine-induced hepatitis in rats.
Topics: Acute-Phase Reaction; Alanine Transaminase; Alkaline Phosphatase; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Diet; Galactosamine; Glucuronidase; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Zinc | 1994 |
Hepatoprotective effects of Taiwan folk medicine: wedelia chinensis on three hepatotoxin-induced hepatotoxicity.
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Analysis of Variance; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drugs, Chinese Herbal; Galactosamine; Liver; Male; Mice; Mice, Inbred ICR; Microscopy, Fluorescence; Paraffin Embedding; Random Allocation; Rats; Rats, Wistar; Taiwan | 1994 |
Increased sinusoidal efflux of reduced and oxidized glutathione in rats with endotoxin/D-galactosamine hepatitis.
Topics: Animals; Chemical and Drug Induced Liver Injury; Endotoxins; Galactosamine; Glutathione; Glutathione Disulfide; Liver; Male; Osmolar Concentration; Rats; Rats, Wistar | 1994 |
Protective and therapeutic effects of ban-zhi-lian on hepatotoxin-induced liver injuries.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Galactosamine; Liver; Male; Mice; Mice, Inbred ICR; Rats; Rats, Wistar | 1994 |
Increase in the plasma concentration of reduced glutathione observed in rats with liver damage induced by lipopolysaccharide/D-galactosamine: effects of ulinastatin, a urinary trypsin inhibitor.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Glutathione; Glycoproteins; Lipopolysaccharides; Male; Neutrophils; Rats; Rats, Wistar; Trypsin Inhibitors | 1993 |
Protective action of putrescine against rat liver injury.
Topics: Administration, Oral; Animals; Carbon Tetrachloride Poisoning; Cell Membrane; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chenodeoxycholic Acid; Galactosamine; Lipid Peroxidation; Liver; Liver Diseases; Male; Octoxynol; Peroxides; Putrescine; Rats; Rats, Sprague-Dawley; tert-Butylhydroperoxide | 1994 |
[Effects of magnesium lithospermate B on D-galactosamine induced rat liver injury].
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Galactosamine; Liver; Male; Prostaglandin D2; Rats; Rats, Wistar | 1993 |
Pharmacokinetics of indocyanine green in rats with experimentally induced hepatic diseases.
Topics: Acute Disease; Animals; Bile; Blood Proteins; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholestasis; Galactosamine; Indocyanine Green; Liver; Liver Circulation; Liver Diseases; Male; Metabolic Clearance Rate; Rats; Rats, Wistar | 1993 |
Pharmacokinetics and pharmacodynamics of naproxen in acute experimental hepatitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Proteins; Carrageenan; Chemical and Drug Induced Liver Injury; Galactosamine; Inflammation; Injections, Intravenous; Liver Function Tests; Liver Regeneration; Male; Naproxen; Protein Binding; Rats; Rats, Wistar | 1993 |
Association of galactosamine-induced hepatitis in the rat with hyperhyaluronanaemia and decreased hyaluronan uptake by the isolated, perfused liver.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Gadolinium; Galactosamine; Hyaluronic Acid; In Vitro Techniques; Liver; Male; Perfusion; Rats; Rats, Sprague-Dawley | 1993 |
Protective effect of E3330, a novel quinone derivative, in galactosamine-induced hepatitis in rats.
Topics: Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Endotoxins; Galactosamine; Lipopolysaccharides; Male; Propionates; Rats; Rats, Inbred F344 | 1993 |
Prevention of galactosamine-induced hepatic damage by picroliv: study on bile flow and isolated hepatocytes (ex vivo).
Topics: Animals; Bile; Chemical and Drug Induced Liver Injury; Cinnamates; Female; Galactosamine; Glycosides; In Vitro Techniques; Liver Diseases; Male; Plant Extracts; Rats; Silymarin; Vanillic Acid | 1993 |
Macrophage enhancement of galactosamine hepatotoxicity using a rat hepatocyte culture system.
Topics: Animals; Cell Communication; Cells, Cultured; Chemical and Drug Induced Liver Injury; Galactosamine; Leukotriene D4; Liver; Macrophage Activation; Macrophages, Peritoneal; Male; Nitric Oxide; Rats; Rats, Inbred Strains | 1995 |
Effect of ursodeoxycholic acid on biochemical parameters, hepatocyte proliferation and liver histology in galactosamine hepatitis in the rat.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cell Division; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Male; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar; Ursodeoxycholic Acid | 1995 |
The effect of endotoxin and Lactobacillus pretreatment on peritoneal macrophage behavior in acute liver injury in rat.
Topics: Animals; Calorimetry; Chemical and Drug Induced Liver Injury; Endotoxins; Free Radicals; Galactosamine; Hot Temperature; Lactobacillus; Liver; Liver Diseases; Luminescent Measurements; Macrophages, Peritoneal; Male; Phagocytosis; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Tetradecanoylphorbol Acetate | 1996 |
Role of platelet-activating factor in pathogenesis of galactosamine-lipopolysaccharide-induced liver injury.
Topics: Animals; Azepines; Cell Adhesion; Cells, Cultured; Chemical and Drug Induced Liver Injury; Endothelium; Escherichia coli; Galactosamine; Lipopolysaccharides; Liver; Male; Neutrophils; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Triazoles; Tumor Necrosis Factor-alpha | 1996 |
Expression of heparin-binding EGF-like growth factor in rat liver injured by carbon tetrachloride or D-galactosamine.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Epidermal Growth Factor; Galactosamine; Gene Expression; Heparin; Liver; Liver Diseases; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1996 |
Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A.
Topics: Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Concanavalin A; DNA Damage; Enterotoxins; Enzyme-Linked Immunosorbent Assay; Galactosamine; Immune Sera; Interferon-gamma; Liver; Liver Failure; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Recombinant Proteins; T-Lymphocytes; Transaminases; Tumor Necrosis Factor-alpha | 1996 |
Interleukin 10 reduces lethality and hepatic injury induced by lipopolysaccharide in galactosamine-sensitized mice.
Topics: Animals; Cell Adhesion Molecules; Chemical and Drug Induced Liver Injury; Galactosamine; Immunization; Immunohistochemistry; Interleukin-10; Lipopolysaccharides; Liver; Liver Diseases; Mice; Mice, Inbred BALB C; Neutrophils; Peroxidase; Tumor Necrosis Factor-alpha | 1996 |
Dietary wheat gluten alleviates the elevation of serum transaminase activities in D-galactosamine-injected rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Dietary Proteins; Galactosamine; Glutamic Acid; Glutens; Kinetics; Lysine; Male; Rats; Rats, Wistar; Threonine; Triticum; Uracil Nucleotides | 1996 |
Pharmacokinetics of glycyrrhizin in rats with D-galactosamine-induced hepatic disease.
Topics: Administration, Oral; Animals; Antiviral Agents; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Gastric Emptying; Glycyrrhetinic Acid; Glycyrrhizic Acid; Injections, Intravenous; Intestinal Absorption; Liver Diseases; Male; Rats; Rats, Wistar | 1996 |
Immunohistochemical study of proteoglycans in D-galactosamine-induced acute liver injury in rats.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Dermatan Sulfate; Disease Models, Animal; Extracellular Matrix; Galactosamine; Heparitin Sulfate; Immunohistochemistry; Liver; Liver Diseases; Male; Microscopy, Electron; Proliferating Cell Nuclear Antigen; Proteoglycans; Rats; Rats, Sprague-Dawley | 1996 |
Protective effect of celosian, an acidic polysaccharide, on chemically and immunologically induced liver injuries.
Topics: Animals; Bilirubin; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Enzymes; Galactosamine; Glycyrrhetinic Acid; Glycyrrhizic Acid; Lipid Peroxidation; Lipid Peroxides; Lipopolysaccharides; Liver; Liver Diseases; Male; Mice; Mice, Inbred BALB C; Necrosis; Plant Extracts; Polysaccharides; Rats; Rats, Sprague-Dawley; Seeds; Tumor Necrosis Factor-alpha | 1996 |
The effect of pretreatment with endotoxin and lactobacillus on bacterial translocation in acute liver injury.
Topics: Animals; Bacterial Translocation; Chemical and Drug Induced Liver Injury; Endotoxins; Galactosamine; Lactobacillus; Liver Diseases; Rats; Rats, Sprague-Dawley | 1996 |
Effects of dietary gluten on the hepatotoxic action of galactosamine and/or endotoxin in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Caseins; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Endotoxins; Galactosamine; Glutens; L-Lactate Dehydrogenase; Liver Diseases; Male; Rats; Rats, Wistar | 1996 |
The effect of ethanol or hepatotoxin exposure on rat transferrin desialylation.
Topics: Acetaldehyde; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Ethanol; Galactosamine; Liver Diseases, Alcoholic; Liver Function Tests; Rats; Transferrin | 1996 |
Minimal effect of acute experimental hepatitis induced by lipopolysaccharide/D-galactosamine on biotransformation in rats.
Topics: Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Galactosamine; gamma-Glutamyltransferase; Glucuronosyltransferase; Glutathione Transferase; Intestines; Kidney; Lipopolysaccharides; Liver; Male; Rats; Rats, Sprague-Dawley; Spleen | 1996 |
Involvement of 26-kDa cell-associated TNF-alpha in experimental hepatitis and exacerbation of liver injury with a matrix metalloproteinase inhibitor.
Topics: Animals; Chemical and Drug Induced Liver Injury; Concanavalin A; Dipeptides; Drug Synergism; Galactosamine; Lipopolysaccharides; Liver; Metalloendopeptidases; Mice; Mice, Inbred C57BL; Protease Inhibitors; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 1997 |
Effect of dietary L-glutamine on the hepatotoxic action of D-galactosamine in rats.
Topics: Alanine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Diet; Galactosamine; Glutamic Acid; Glutamine; L-Lactate Dehydrogenase; Liver Diseases; Male; Neomycin; Rats; Rats, Wistar; Stereoisomerism | 1996 |
[Immunomodulating and hepatoprotective action of retinoids in toxic liver involvement induced by D-galactosamine].
Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Antioxidants; beta Carotene; Chemical and Drug Induced Liver Injury; Erythrocytes; Galactosamine; Immunosuppressive Agents; Lipid Peroxidation; Rats; Rats, Wistar; Sheep; Stereoisomerism; Vitamin A | 1996 |
The effect of a pulsed magnetic field and that of methyl-silane triol on galactosamine induced hepatitis among rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Magnetics; Male; Organosilicon Compounds; Rats; Rats, Wistar; Salicylates | 1996 |
Preventive effect of lithospermate B from Salvia miltiorhiza on experimental hepatitis induced by carbon tetrachloride or D-galactosamine/lipopolysaccharide.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Galactosamine; In Vitro Techniques; Lipopolysaccharides; Male; Medicine, Chinese Traditional; Mice; Plants, Medicinal; Rats; Rats, Sprague-Dawley | 1997 |
Cholesteryl hemisuccinate treatment protects rodents from the toxic effects of acetaminophen, adriamycin, carbon tetrachloride, chloroform and galactosamine.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chloroform; Cholesterol Esters; Doxorubicin; Galactosamine; Heart Diseases; Liver Diseases; Male; Mice; Mice, Inbred ICR; Rats; Rats, Sprague-Dawley | 1997 |
Evaluation of four prescriptions of traditional Chinese medicine: syh-mo-yiin, guizhi-fuling-wan, shieh-qing-wan and syh-nih-sann on experimental acute liver damage in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Evaluation, Preclinical; Galactosamine; Male; Medicine, Chinese Traditional; Plant Extracts; Rats; Rats, Wistar | 1997 |
Efficacy of a selective histamine H2 receptor agonist, dimaprit, in experimental models of endotoxin shock and hepatitis in mice.
Topics: Alanine Transaminase; Animals; Biomarkers; Blotting, Northern; Chemical and Drug Induced Liver Injury; Dimaprit; Galactosamine; Histamine Agonists; Humans; In Vitro Techniques; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred BALB C; Monocytes; Shock, Septic; Tumor Necrosis Factor-alpha | 1997 |
Hepatoprotective effect of Hovenia dulcis THUNB. on experimental liver injuries induced by carbon tetrachloride or D-galactosamine/lipopolysaccharide.
Topics: Animals; Carbon Tetrachloride Poisoning; Cells, Cultured; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Flavonoids; Galactosamine; Lipopolysaccharides; Liver; Male; Plant Extracts; Rats; Rats, Sprague-Dawley | 1997 |
Effects of Cuban red propolis on galactosamine-induced hepatitis in rats.
Topics: Administration, Oral; Alanine Transaminase; Analysis of Variance; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Male; Malondialdehyde; Microscopy, Electron; Propolis; Rats; Rats, Sprague-Dawley | 1997 |
Immunohistochemical study on galactosamine-induced subacute hepatitis in rats of JCL: Wistar-TGN (ARGHGEN) 1 Nts strain (Mini rats).
Topics: Acute Disease; alpha-Fetoproteins; Animals; Cell Division; Chemical and Drug Induced Liver Injury; Extracellular Matrix Proteins; Galactosamine; Immunohistochemistry; Liver; Male; Rats; Rats, Wistar | 1997 |
Inhibition of nitric oxide modulates the effect of oral arginine supplementation in acute liver injury.
Topics: Acute Disease; Administration, Oral; Alanine Transaminase; Analysis of Variance; Animals; Arginine; Aspartate Aminotransferases; Bacterial Translocation; Bilirubin; Chemical and Drug Induced Liver Injury; Colony Count, Microbial; Disease Models, Animal; DNA; Enzyme Inhibitors; Food, Fortified; Galactosamine; Intestinal Mucosa; Liver Diseases; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; RNA | 1997 |
Prolonged oval cell proliferation with Ito cell activation and extracellular matrix accumulation in galactosamine-induced acute hepatitis in mini rats.
Topics: Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Extracellular Matrix; Galactosamine; Immunohistochemistry; Liver; Male; Rats; Rats, Wistar | 1997 |
Apoptosis of murine hepatocytes induced by high doses of galactosamine.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Dose-Response Relationship, Drug; Electrophoresis, Agar Gel; Galactosamine; Histocytochemistry; Injections, Intraperitoneal; Liver; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron; Necrosis; Time Factors | 1997 |
Comparative study of oral and parenteral administration of sho-saiko-to (xiao-chaihu-tang) extract on D-galactosamine-induced liver injury in rats.
Topics: 5'-Nucleotidase; Administration, Oral; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drugs, Chinese Herbal; Galactosamine; Glucose-6-Phosphatase; Hypolipidemic Agents; Injections, Intraperitoneal; Liver Diseases; Male; Rats; Rats, Wistar; Serum Albumin; Triglycerides | 1997 |
Protective action of hepatocyte growth factor for acute liver injury caused by D-galactosamine in transgenic mice.
Topics: Acute Disease; Alanine Transaminase; Animals; Antibodies; Chemical and Drug Induced Liver Injury; Dinoprostone; Dose-Response Relationship, Drug; Galactosamine; Hepatocyte Growth Factor; Humans; Injections, Intravenous; Liver; Mice; Mice, Inbred Strains; Mice, Transgenic; Portal Vein; Proliferating Cell Nuclear Antigen; Staining and Labeling; Survival Analysis | 1997 |
Hepatoprotective principles of Swertia japonica Makino on D-galactosamine/lipopolysaccharide-induced liver injury in mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Glucosides; Iridoid Glucosides; Iridoids; Lipopolysaccharides; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred Strains; Plant Extracts; Plants, Medicinal; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet | 1997 |
Green tea suppresses D-galactosamine-induced liver injury in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dietary Supplements; Galactosamine; Liver Diseases; Male; Plant Extracts; Rats; Rats, Wistar; Tea | 1998 |
Antihepatotoxic activity of monomethyl fumarate isolated from Fumaria indica.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Fumarates; Galactosamine; Liver; Male; Maleates; Plant Extracts; Rats; Rats, Wistar; Rifampin; Silymarin; Thioacetamide | 1998 |
[Pharmacologic regulation of hepatocyte cytolysis by antioxidants during acute D-galactosamine hydrochloride intoxication].
Topics: Animals; Antioxidants; Cell Membrane; Chemical and Drug Induced Liver Injury; Drug Synergism; Female; Galactosamine; Lipid Peroxidation; Liver; Male; Rats; Sodium Selenite; Stereoisomerism; Vitamin E | 1998 |
Effect of 4-phenyl-1,3-dithia-2-thioxo-cyclopent-4-ene on liver injury induced by repeated exposure to galactosamine plus carbon tetrachloride in rats.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Galactosamine; Heterocyclic Compounds, 1-Ring; Liver Diseases; Male; Rats; Rats, Wistar; Thioacetamide; Thiones | 1998 |
Endothelin 1 aggravates acute liver injury in perfused livers of rats after treatment with D-galactosamine.
Topics: Acute Disease; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-3; Galactosamine; Hemodynamics; L-Lactate Dehydrogenase; Liver; Liver Circulation; Liver Diseases; Male; Perfusion; Rats; Rats, Sprague-Dawley; Thromboxane A2 | 1998 |
Aggravating action of zymosan on acute liver damage in perfused liver of rats treated with D-galactosamine.
Topics: Acute Disease; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Eicosanoids; Gadolinium; Galactosamine; Hemodynamics; Immunohistochemistry; L-Lactate Dehydrogenase; Liver; Liver Circulation; Liver Diseases; Macrophages; Male; Perfusion; Permeability; Rats; Rats, Sprague-Dawley; Reference Values; Zymosan | 1998 |
Low levels of serum acylcarnitine in chronic fatigue syndrome and chronic hepatitis type C, but not seen in other diseases.
Topics: Acute Disease; Animals; Carnitine; Chemical and Drug Induced Liver Injury; Diabetes Mellitus; Fatigue Syndrome, Chronic; Female; Galactosamine; Hepatitis C, Chronic; Humans; Japan; Male; Mice; Mice, Inbred C3H; Neoplasms; Sweden | 1998 |
Inhibitory effect and action mechanism of sesquiterpenes from Zedoariae Rhizoma on D-galactosamine/lipopolysaccharide-induced liver injury.
Topics: Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Galactosamine; Lipopolysaccharides; Liver; Male; Mice; Nitric Oxide; Plants; Rats; Rats, Wistar; Sesquiterpenes | 1998 |
Increased serum levels and sinusoidal expression of thrombomodulin in acute liver damage.
Topics: Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Liver Diseases; Male; Rabbits; Rats; Rats, Sprague-Dawley; Thrombomodulin | 1999 |
NO contribution to lipopolysaccharide-induced hepatic damage in galactosamine-sensitized mice.
Topics: Aniline Hydroxylase; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Galactosamine; L-Lactate Dehydrogenase; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Microsomes, Liver; Nitric Oxide | 1999 |
Antihepatotoxic activity of Swertia chirata on paracetamol and galactosamine induced hepatotoxicity in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Galactosamine; Liver Diseases; Liver Function Tests; Male; Phytotherapy; Plant Extracts; Rats | 1999 |
Suppression of lipopolysaccharide-induced tumor necrosis factor-release and liver injury in mice by naringin.
Topics: Alanine Transaminase; Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Creatine Kinase; Female; Flavanones; Flavonoids; Galactosamine; In Situ Nick-End Labeling; Lipopolysaccharides; Liver; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Tumor Necrosis Factor-alpha | 1999 |
Effect of PGE1 on TNF-alpha status and hepatic D-galactosamine-induced apoptosis in rats.
Topics: Alprostadil; Animals; Apoptosis; Cell Cycle; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Male; Microscopy, Electron; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 1998 |
Suppression of D-galactosamine-induced rat liver injury by glycosidic flavonoids-rich fraction from green tea.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Diet; Flavonoids; Galactosamine; Liver; Male; Rats; Rats, Wistar; Tea | 1999 |
Inhibitory effect of tetrahydroswertianolin on tumor necrosis factor-alpha-dependent hepatic apoptosis in mice.
Topics: Analysis of Variance; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Enzyme-Linked Immunosorbent Assay; Galactosamine; Glucosides; Iridoid Glucosides; Iridoids; Lipopolysaccharides; Liver Diseases; Male; Mice; Protective Agents; Tumor Necrosis Factor-alpha | 1999 |
Ameliorative effect of an urinary preparation on acetaminophen and D-galactosamine induced hepatotoxicity in rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Glutathione; Humans; Lipid Peroxidation; Liver; Liver Diseases; Male; Rats; Rats, Wistar; Urine | 1999 |
Teas and other beverages suppress D-galactosamine-induced liver injury in rats.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Aspartate Aminotransferases; Beverages; Blood Glucose; Cacao; Caffeine; Central Nervous System Stimulants; Chemical and Drug Induced Liver Injury; Coffee; Dietary Fiber; Galactosamine; Liver Diseases; Male; Organ Size; Rats; Rats, Wistar; Tea; Weight Gain | 1999 |
Free-radical scavenging action of medicinal herbs from Ghana: Thonningia sanguinea on experimentally-induced liver injuries.
Topics: Alanine Transaminase; Aniline Hydroxylase; Animals; Antioxidants; Aspartate Aminotransferases; Bepridil; Biphenyl Compounds; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Free Radical Scavengers; Free Radicals; Galactosamine; Ghana; Glutathione Transferase; Lipid Peroxidation; Liver; Liver Diseases; Male; Mice; Microsomes, Liver; Picrates; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances | 1999 |
Acteoside inhibits apoptosis in D-galactosamine and lipopolysaccharide-induced liver injury.
Topics: Alanine Transaminase; Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; Cell Survival; Chemical and Drug Induced Liver Injury; DNA; Drug Synergism; Galactosamine; Glucosides; Lipopolysaccharides; Liver; Liver Failure; Male; Mice; Phenols; Plant Extracts; Tumor Necrosis Factor-alpha | 1999 |
The role of complement activation in tumour necrosis factor-induced lethal hepatitis.
Topics: Animals; Chemical and Drug Induced Liver Injury; Complement Activation; Complement C1q; Complement C3b; Complement Pathway, Alternative; Complement Pathway, Classical; Elapid Venoms; Female; Galactosamine; Liver; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CBA; Tumor Necrosis Factor-alpha | 1999 |
The anti-inflammatory and hepatoprotective effects of fractions from Cudrania cochinchinensis var. gerontogea.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Carrageenan; Chemical and Drug Induced Liver Injury; Edema; Galactosamine; Liver; Male; Mice; Mice, Inbred ICR; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar | 1999 |
Enhancement by galactosamine of lipopolysaccharide(LPS)-induced tumour necrosis factor production and lethality: its suppression by LPS pretreatment.
Topics: Animals; Blood Proteins; Chemical and Drug Induced Liver Injury; Clodronic Acid; Dose-Response Relationship, Drug; Female; Galactosamine; Hot Temperature; Interleukin-1; Lipopolysaccharides; Liposomes; Liver; Macrophages; Mice; Mice, Inbred C57BL; Models, Biological; Time Factors; Tumor Necrosis Factor-alpha; Uridine | 1999 |
Effect of propolis extract on D-galactosamine-induced hepatic injury in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Dextrans; Galactosamine; Male; Propolis; Rats; Rats, Wistar | 1999 |
Tumor necrosis factor-induced lethal hepatitis: pharmacological intervention with verapamil, tannic acid, picotamide and K76COOH.
Topics: Alanine Transaminase; Animals; Apoptosis; Astringents; Chemical and Drug Induced Liver Injury; Complement Inactivator Proteins; Dactinomycin; Disease Models, Animal; Galactosamine; Hydrolyzable Tannins; Liver; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Phthalic Acids; Platelet Aggregation Inhibitors; Sesquiterpenes; Tumor Necrosis Factor-alpha; Verapamil | 2000 |
Protective effects of bergenin, the major constituent of Mallotus japonicus, on D-galactosamine-intoxicated rat hepatocytes.
Topics: Alanine Transaminase; Animals; Benzopyrans; Cell Separation; Cells, Cultured; Chemical and Drug Induced Liver Injury; Galactosamine; Plants, Medicinal; Rats; Rats, Wistar; RNA; Succinate Dehydrogenase | 2000 |
TNF-alpha but not IL-1alpha is correlated with PGE1-dependent protection against acute D-galactosamine-induced liver injury.
Topics: Alanine Transaminase; Alprostadil; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Humans; Interleukin-1; Liver; Male; Nitric Oxide; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2000 |
Lipopolysaccharide and D-galactosamine-induced hepatic injury is mediated by TNF-alpha and not by Fas ligand.
Topics: Animals; Apoptosis; Carrier Proteins; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Fas Ligand Protein; fas Receptor; Female; Galactosamine; Gene Expression; Lipopolysaccharides; Liver; Liver Diseases; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mutation; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Recombinant Fusion Proteins; RNA, Messenger; Tumor Necrosis Factor Decoy Receptors; Tumor Necrosis Factor-alpha | 2000 |
LPS-induced liver injury in D-galactosamine-sensitized mice requires secreted TNF-alpha and the TNF-p55 receptor.
Topics: Alanine Transaminase; Animals; Antigens, CD; Apoptosis; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Lipopolysaccharides; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Tumor Necrosis Factor-alpha | 2000 |
Aggravation of chemically-induced injury in perfused rat liver by extracellular ATP.
Topics: Adenosine Triphosphate; Animals; Chemical and Drug Induced Liver Injury; Gadolinium; Galactosamine; Hemodynamics; Liver; Male; Purinergic Antagonists; Rats; Rats, Sprague-Dawley | 2000 |
Effect of HD-03--a herbal formulation in galactosamine-induced hepatopathy in rats.
Topics: Animals; Bile Ducts; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Liver; Liver Function Tests; Magnoliopsida; Male; Necrosis; Phytotherapy; Plant Extracts; Rats; Rats, Wistar | 2000 |
Hepatoprotection by human epidermal growth factor (hEGF) against experimental hepatitis induced by D-galactosamine (D-galN) or D-GalN/lipopolysaccharide.
Topics: Animals; Chemical and Drug Induced Liver Injury; Epidermal Growth Factor; Galactosamine; Humans; Lipopolysaccharides; Liver Function Tests; Male; Mice; Mice, Inbred BALB C; Nitric Oxide; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Transaminases; Tumor Necrosis Factor-alpha | 2000 |
Pathophysiologic importance of E- and L-selectin for neutrophil-induced liver injury during endotoxemia in mice.
Topics: Animals; Antibodies; Chemical and Drug Induced Liver Injury; E-Selectin; Endothelium, Vascular; Endotoxemia; Galactosamine; L-Selectin; Liver; Liver Circulation; Liver Diseases; Male; Mice; Mice, Inbred C3H; Mice, Knockout; Neutrophils | 2000 |
Nigella sativa L. oil protects against induced hepatotoxicity and improves serum lipid profile in rats.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cholesterol; Galactosamine; Lipids; Lipoproteins, HDL; Lipoproteins, LDL; Liver Function Tests; Male; Plant Oils; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Triglycerides | 2000 |
Hepatoprotective constituents of the seeds of Combretum quadrangulare.
Topics: Animals; Cell Death; Cells, Cultured; Chemical and Drug Induced Liver Injury; Combretum; Galactosamine; Hepatocytes; Liver; Male; Mice; Plant Extracts; Seeds; Tumor Necrosis Factor-alpha; Vietnam | 2000 |
Glycosidic flavonoids as rat-liver injury preventing compounds from green tea.
Topics: Animals; Carbohydrate Sequence; Chemical and Drug Induced Liver Injury; Flavonoids; Galactosamine; Glycosides; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Rats; Spectrometry, Mass, Fast Atom Bombardment | 2000 |
Sensitivity of metallothionein-null mice to LPS/D-galactosamine-induced lethality.
Topics: Animals; Chemical and Drug Induced Liver Injury; Death; Escherichia coli; Galactosamine; Gene Expression Regulation; Lipopolysaccharides; Male; Metallothionein; Mice; Mice, Inbred Strains; Mice, Knockout; Nitrogen Oxides; Orosomucoid; RNA, Messenger; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2001 |
Hepatoprotective constituents from zedoariae rhizoma: absolute stereostructures of three new carabrane-type sesquiterpenes, curcumenolactones A, B, and C.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Galactosamine; Hepatocytes; Lactones; Lipopolysaccharides; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Plants, Medicinal; Rats; Sesquiterpenes; Spectrophotometry, Ultraviolet | 2001 |
Liver injury suppressing compounds from avocado (Persea americana).
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Liver Diseases; Persea; Phytotherapy; Rats | 2001 |
Effect of Indigofera tinctoria Linn on liver antioxidant defense system during D-galactosamine/endotoxin-induced acute hepatitis in rodents.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Endotoxins; Galactosamine; Liver; Male; Plant Extracts; Rats; Rats, Wistar; Rosales | 2001 |
Effects of bergenin, the major constituent of Mallotus japonicus against D-galactosamine-induced hepatotoxicity in rats.
Topics: Animals; Anti-Ulcer Agents; Benzopyrans; Chemical and Drug Induced Liver Injury; Galactosamine; Glutathione; Lipid Peroxidation; Liver Diseases; Malondialdehyde; Rats; Rats, Sprague-Dawley | 2001 |
Medicinal foodstuffs. XXV. Hepatoprotective principle and structures of ionone glucoside, phenethyl glycoside, and flavonol oligoglycosides from young seedpods of garden peas, Pisum sativum L.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Flavanones; Flavonoids; Galactosamine; Glucosides; Glycosides; Hepatocytes; Injections, Intraperitoneal; Lipopolysaccharides; Liver Diseases; Male; Mice; Pisum sativum; Plant Extracts; Plants, Medicinal; Seeds | 2001 |
Suppressive effect of coffee on lipopolysaccharide-induced hepatitis in D-galactosamine-sensitized rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Caffeine; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Coffee; Diet; Endotoxins; Galactosamine; Lipopolysaccharides; Male; Phosphodiesterase Inhibitors; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Tea | 2001 |
Alpha B-crystallin expression in human and rat hepatic stellate cells.
Topics: Actins; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Crystallins; Desmin; Galactosamine; Gene Expression; Humans; Immunohistochemistry; Liver; Male; Nucleic Acid Hybridization; Rats; Rats, Inbred WKY; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation | 2001 |
Involvement of a serine protease, but not of neutrophil elastase, in tumor necrosis factor-induced lethal hepatitis and induction of platelet-activating factor.
Topics: Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Drug Combinations; Galactosamine; Leukocyte Elastase; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Knockout; Platelet Activating Factor; Serine Endopeptidases; Tumor Necrosis Factor-alpha | 2001 |
O(2)-Vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate protection against D-galactosamine/endotoxin-induced hepatotoxicity in mice: genomic analysis using microarrays.
Topics: Animals; Antigens, CD; Apoptosis; Blotting, Western; Caspase 3; Caspases; Chemical and Drug Induced Liver Injury; Endotoxins; Galactosamine; Gene Expression Regulation; Genome; Immunohistochemistry; Lipopolysaccharides; Male; Mice; NF-kappa B; Oligonucleotide Array Sequence Analysis; Pyrrolidines; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Signal Transduction; Tumor Necrosis Factor-alpha | 2002 |
Genetic determinants of lipopolysaccharide and D-galactosamine-mediated hepatocellular apoptosis and lethality.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Galactosamine; Humans; Lipopolysaccharides; Liver; Liver Diseases; Longevity; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Knockout; Mice, Transgenic; Necrosis; Recombinant Proteins; Species Specificity; Tumor Necrosis Factor-alpha | 2001 |
Hepatoprotective principles from the flowers of Tilia argentea (linden): structure requirements of tiliroside and mechanisms of action.
Topics: Alkyl and Aryl Transferases; Animals; Benzopyrans; Carbon Tetrachloride; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Enzyme Inhibitors; Flavonoids; Galactosamine; Hepatocytes; Lipopolysaccharides; Liver; Macrophages, Peritoneal; Male; Mice; Plant Extracts; Plant Structures; Tiliaceae; Transferases (Other Substituted Phosphate Groups); Tumor Necrosis Factor-alpha | 2002 |
Protective effect of Linomide on TNF-alpha-induced hepatic injury.
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents; Cell Adhesion; Cell Communication; Chemical and Drug Induced Liver Injury; Endothelium, Vascular; Galactosamine; Hydroxyquinolines; Leukocytes; Liver; Liver Diseases; Male; Microcirculation; Rats; Rats, Sprague-Dawley; Sepsis; Tumor Necrosis Factor-alpha | 2002 |
A20 protects mice from D-galactosamine/lipopolysaccharide acute toxic lethal hepatitis.
Topics: Adenoviridae; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cysteine Endopeptidases; Cytokines; Cytoprotection; DNA-Binding Proteins; Galactosamine; Genetic Therapy; Hepatocytes; Humans; Inflammation; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Liver Failure; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Nuclear Proteins; Proteins; Receptors, Tumor Necrosis Factor; Tumor Cells, Cultured; Tumor Necrosis Factor alpha-Induced Protein 3 | 2002 |
Diethyldithiocarbamate inhibition of galactosamine-induced hepatitis in rats.
Topics: Acute Disease; Alanine Transaminase; Animals; Antioxidants; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Ditiocarb; Galactosamine; Glucuronidase; Male; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2002 |
Tumor necrosis factor-alpha-null mice are not resistant to cadmium chloride-induced hepatotoxicity.
Topics: Alanine Transaminase; Animals; Apoptosis; Cadmium Chloride; Caspase 3; Caspases; Chemical and Drug Induced Liver Injury; Galactosamine; Histocytochemistry; L-Iditol 2-Dehydrogenase; Lipopolysaccharides; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Tumor Necrosis Factor-alpha | 2002 |
Medicinal foodstuffs. XXIX. Potent protective effects of sesquiterpenes and curcumin from Zedoariae Rhizoma on liver injury induced by D-galactosamine/lipopolysaccharide or tumor necrosis factor-alpha.
Topics: Animals; Chemical and Drug Induced Liver Injury; Curcumin; Galactosamine; Indicators and Reagents; Lipopolysaccharides; Liver Function Tests; Male; Mice; Plant Extracts; Sesquiterpenes; Tumor Necrosis Factor-alpha; Zingiberaceae | 2002 |
TNF tolerance and cytotoxicity in the liver: the role of interleukin-1beta, inducible nitric oxide-synthase and heme oxygenase-1 in D-galactosamine-sensitized mice.
Topics: Animals; Antigens, CD; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Drug Tolerance; Galactosamine; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Immunohistochemistry; Interleukin-1; Liver; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha | 2002 |
Hepatoprotective effect of majonoside R2, the major saponin from Vietnamese ginseng (Panax vietnamensis).
Topics: Animals; Apoptosis; Carbohydrate Sequence; Chemical and Drug Induced Liver Injury; Galactosamine; Ginsenosides; Hepatocytes; Lipopolysaccharides; Liver; Liver Diseases; Male; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Molecular Structure; Panax; Plant Extracts; Saponins; Tumor Necrosis Factor-alpha; Vietnam | 2002 |
PGE1 protection against apoptosis induced by D-galactosamine is not related to the modulation of intracellular free radical production in primary culture of rat hepatocytes.
Topics: Alprostadil; Animals; Apoptosis; Caspase 3; Caspases; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Flow Cytometry; Free Radicals; Galactosamine; Glutathione; Hepatocytes; L-Lactate Dehydrogenase; Lipid Peroxidation; Liver; Male; Membrane Potentials; Mitochondria; Necrosis; Platelet Aggregation Inhibitors; Ploidies; Rats; Rats, Wistar; Reactive Oxygen Species; Thiobarbituric Acid Reactive Substances | 2002 |
[The effect of prednisolone on the development of the galactosamine hepatitis of young and old rats (author's transl)].
Topics: Age Factors; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Galactosamine; Humans; Prednisolone; Rats | 1976 |
[Incorporation of 14-C-Glycine during galactosamine hepatitis of young and old rats (author's transl)a*].
Topics: Age Factors; Animals; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Glycine; Liver; Lysosomes; Prednisolone; Protein Biosynthesis; Rats | 1976 |
[Clinical and experimental histochemical studies on the activities of liver lysosomal enzymes and gamma-glutamyl transpeptidase (gamma-GTP) (author's transl)].
Topics: Acetylglucosaminidase; Acid Phosphatase; Adenosine Triphosphatases; Alcoholism; Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Ethanol; Galactosamine; gamma-Glutamyltransferase; Glucuronidase; Histocytochemistry; Humans; Liver; Liver Diseases; Lysosomes; Male; Phenobarbital; Rats | 1978 |
Histochemical studies on carbohydrate metabolism in rat liver after galactosamine administration.
Topics: Acid Phosphatase; Animals; Carbohydrate Metabolism; Chemical and Drug Induced Liver Injury; Galactosamine; Glucose-6-Phosphatase; Glycogen; Liver; Male; Phosphorylases; Rats; Succinate Dehydrogenase | 1979 |
Induction of tyrosine aminotransferase in galactosamine hepatitis.
Topics: Animals; Chemical and Drug Induced Liver Injury; Enzyme Induction; Galactosamine; Hydrocortisone; Liver; Male; Rats; Tyrosine Transaminase | 1979 |
Investigations on d-galactosamine hepatitis after pretreatment with alpha-hexachlorocyclohexane.
Topics: Alcohol Oxidoreductases; Animals; Chemical and Drug Induced Liver Injury; DNA; Female; Galactosamine; Hexachlorocyclohexane; Liver; Organ Size; Premedication; Rats; Sorbitol; Uracil Nucleotides | 1976 |
Serum alpha-fetoprotein. A prognostic indicator of liver-cell necrosis and regeneration following experimental injury by galactosamine in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; alpha-Fetoproteins; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Hepatitis, Viral, Human; Humans; Liver; Liver Regeneration; Male; Necrosis; Prognosis; Rats; Time Factors | 1976 |
Inflammation inhibiting properties of rat alphaM foetoprotein (rat-alpha2 macroglobulin), an acute phase reactant.
Topics: alpha-Macroglobulins; Animals; Anti-Inflammatory Agents; Bradykinin; Chemical and Drug Induced Liver Injury; Edema; Galactosamine; Histamine; Male; Prostaglandins E; Rats; Serotonin; Time Factors | 1977 |
Inhibitory effects of rat alpha2 macroferoprotein (alphaMFP), an acute phase globulin, on galactosamine hepatitis.
Topics: alpha-Macroglobulins; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Uridine Diphosphate Glucose | 1978 |
[AFP producing cells during liver restitution after acute galactosamine hepatitis in the rat (author's transl)].
Topics: Acute Disease; alpha-Fetoproteins; Animals; Autoradiography; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Immunoenzyme Techniques; Liver; Liver Regeneration; Rats | 1978 |
[Mast-cell degranulation in the intestine: its significance for the pathogenesis of galactosamine hepatitis. Histological and histochemical studies on mast-cells using toluidine-blue and subsequent naphthol-ASD-chloracetate reaction (author's transl)].
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytoplasmic Granules; Endotoxins; Galactosamine; Intestinal Mucosa; Male; Mast Cells; Naphthol AS D Esterase; Rats; Staining and Labeling; Tolonium Chloride | 1978 |
An animal model of fulminant hepatic failure in the rat.
Topics: Amino Acids; Animals; Brain; Brain Chemistry; Brain Edema; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Hepatic Encephalopathy; Liver; Liver Diseases; Male; Rats | 1979 |
Protecting action of aspartate on the hepatic changes induced by D-galactosamine.
Topics: Adenosine Triphosphatases; Alanine Transaminase; Alcohol Oxidoreductases; Animals; Aspartate Aminotransferases; Aspartic Acid; Chemical and Drug Induced Liver Injury; Dihydrolipoamide Dehydrogenase; Galactosamine; Glucose-6-Phosphatase; Lactates; Liver; Liver Glycogen; Pyruvates; Rats | 1976 |
[The action of silymarin on Galactosamine-induced hepatitis in the rat (author's transl)].
Topics: Acid Phosphatase; Adenosine Triphosphatases; Animals; Cell Membrane; Chemical and Drug Induced Liver Injury; Drug Evaluation; Flavonoids; Galactosamine; Glucose-6-Phosphatase; Liver; Liver Glycogen; Male; Mitochondria, Liver; Nucleic Acids; Oxidoreductases; Rats; Silymarin | 1977 |
Plasma membrane of the regenerating rat liver. Plasma membrane as a key target organelle in galactosamine-induced hepatitis.
Topics: Alkaline Phosphatase; Animals; Cell Membrane; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Glucose-6-Phosphatase; Hepatitis; Liver; Liver Regeneration; Lysophosphatidylcholines; Membrane Lipids; Nucleotidases; Rats; Sodium-Potassium-Exchanging ATPase | 1979 |
Galactosamine-induced sensitization to the lethal effects of endotoxin.
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Synergism; Endotoxins; Female; Galactosamine; L-Iditol 2-Dehydrogenase; Lipid A; Lipopolysaccharides; Liver Diseases; Male; Mice; Rabbits; Rats; Salmonella; Time Factors; Uridine | 1979 |
Hepatocellular transplantation for treatment of D-galactosamine-induced acute liver failure in rats.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Liver; Liver Diseases; Liver Transplantation; Male; Rats | 1979 |
Adaptive changes of rat liver cells induced by repeated intraperitoneal injections of d-galactosamine. I. Light microscopic, autoradiographic and biochemical studies of parenchymal alteration, DNA and RNA synthesis.
Topics: Adaptation, Biological; Animals; Autoradiography; Chemical and Drug Induced Liver Injury; DNA; Female; Galactosamine; Injections, Intraperitoneal; Liver; Rats; RNA; Time Factors | 1977 |
On the pathogenesis of galactosamine hepatitis. Indications of extrahepatocellular mechanisms responsible for liver cell death.
Topics: Animals; Chemical and Drug Induced Liver Injury; Colectomy; Complement System Proteins; Endotoxins; Galactosamine; Male; Mast Cells; Mice; Mice, Inbred Strains; Necrosis; Rats | 1978 |
Biochemical, hematological and histological changes in a fulminant hepatic failure rat model for artificial liver assessment.
Topics: Animals; Artificial Organs; Aspartate Aminotransferases; Bilirubin; Charcoal; Chemical and Drug Induced Liver Injury; Cross Circulation; Galactosamine; Hemoperfusion; Liver; Liver Diseases; Male; Necrosis; Prothrombin Time; Rats | 1979 |
Lipid peroxidation and lysosomal enzymes in D-galactosamine hepatitis and its protection by vitamin E.
Topics: Acid Phosphatase; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Glucuronidase; Lipid Metabolism; Liver; Lysosomes; Oxidation-Reduction; Rats; Vitamin E; Vitamin E Deficiency | 1979 |
Changes in polyamine metabolism of rat liver after administration of D-galactosamine. Favorable effects of putrescine administration on galactosamine-induced hepatic injury.
Topics: Adenosylmethionine Decarboxylase; Animals; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Liver; Liver Regeneration; Ornithine Decarboxylase; Polyamines; Putrescine; Rats; Spermidine | 1979 |
[Antihepatotoxic activity of arginine thiazolidinecarboxylate in hepatitis induced by galactosamine in the rat].
Topics: Animals; Arginine; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Rats; Thiazoles | 1979 |
Changes in glycoproteins of liver plasma membranes from rats treated with D-galactosamine.
Topics: Animals; Carbohydrate Metabolism; Cell Membrane; Chemical and Drug Induced Liver Injury; Electrophoresis, Polyacrylamide Gel; Galactosamine; Glucosamine; Glycoproteins; Liver; Male; Nucleotidases; Rats; Sulfates | 1979 |
[Intravenous and oral galactose loading of rats suffering from galactosamine hepatitis and ANIT-cholestasis; comparison of the kinetics in vivo and the galactose metabolism in the liver in vitro (author's transl)].
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Enzyme Activation; Galactokinase; Galactosamine; Galactose; In Vitro Techniques; Injections, Intravenous; Kinetics; Liver; Male; Rats; Thiocyanates; Time Factors | 1979 |
The influence of ethanol pretreatment on the effects of nine hepatotoxic agents.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Alcoholic Intoxication; Amanitins; Aniline Hydroxylase; Animals; Aspartate Aminotransferases; Bromobenzenes; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Ethanol; Galactosamine; Glutathione; Humans; L-Iditol 2-Dehydrogenase; Liver; Male; Mice; Microsomes, Liver; Organ Size; Phalloidine; Praseodymium; Thioacetamide | 1978 |
Inhibition of hepatic regeneration in rats by acute and chronic ethanol intoxication.
Topics: Alcoholic Intoxication; Alcoholism; Animals; Chemical and Drug Induced Liver Injury; DNA; Ethanol; Female; Galactosamine; Hepatectomy; Humans; Liver Regeneration; Rats; Thymidine | 1979 |
[On the pharmacology of piprozoline (author's transl)].
Topics: Amanitins; Animals; Bile; Bile Acids and Salts; Carbon Tetrachloride Poisoning; Cats; Chemical and Drug Induced Liver Injury; Cholagogues and Choleretics; Dogs; Female; Galactosamine; Lethal Dose 50; Male; Mice; Piperidines; Rats; Thiazoles | 1977 |
The effect of fasting on galactosamine induced hepatitis in experimental animals.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cricetinae; Fasting; Galactosamine; Liver Glycogen; Male; Mesocricetus; Rats; Time Factors | 1977 |
A comparison between the morphologic changes in the livers of hamsters and rats after galactosamine treatment and their correlation with altered serum transaminase levels.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cricetinae; Galactosamine; Liver; Male; Rats; Transaminases | 1977 |
[Effect of the liver protecting compound ES 914 on D-galactosamine induced experimental hepatitis in the rat].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Caproates; Chemical and Drug Induced Liver Injury; Galactosamine; Rats | 1979 |
Role of uridine entrapped in liposomes in galactosamine-induced hepatitis.
Topics: Animals; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Liposomes; Rats; Uridine | 1977 |
Microsomal drug metabolism in acute and chronic galactosamine induced hepatic injuries.
Topics: Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Chronic Disease; Cytochrome P-450 Enzyme System; Female; Galactosamine; Microsomes, Liver; Phospholipids; Proteins; Rats; Triglycerides | 1977 |
Cytoplasmic aggregates in D-galactosamine induced liver injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytoplasmic Granules; Endoplasmic Reticulum; Galactosamine; Histocytochemistry; Liver; Liver Glycogen; Male; Mice; Periodic Acid-Schiff Reaction; Polysaccharides; Ribonucleoproteins; Starvation | 1977 |
Age dependent kinetic studies of cytoplasmic and lysosomal enzymes of the normal and D-galactosamine injured rat liver.
Topics: Acetylglucosaminidase; Age Factors; Alanine Transaminase; Animals; Aspartate Aminotransferases; Cathepsins; Chemical and Drug Induced Liver Injury; Cytoplasm; Female; Galactosamine; Glucuronidase; Hexosaminidases; Injections, Intraperitoneal; Liver; Lysosomes; Prednisolone; Rats; Time Factors | 1978 |
Synergistic action of hepatocyte membrane defect and activated complement system in liver cell death--an experimental approach to fulminant hepatic failure.
Topics: Animals; Cell Membrane; Chemical and Drug Induced Liver Injury; Complement C3; Complement System Proteins; Drug Synergism; Endotoxins; Galactosamine; Necrosis; Rats | 1978 |
D-galactosamine induced hepatic cirrhosis: its ultrastructural and biochemical studies in rat.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cholesterol; Chronic Disease; Cytochromes; Female; Galactosamine; Histocytochemistry; Liver; Organ Size; Phospholipids; Rats; Serum Albumin; Triglycerides | 1978 |
An enzyme-linked immunoassay for ferritin in human serum and rat plasma and the influence of the iron in serum ferritin on serum iron measurement, during acute hepatitis.
Topics: Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Enzyme-Linked Immunosorbent Assay; Ferritins; Galactosamine; Hepatitis; Humans; Iron; Male; Rats | 1978 |
Protective role of S-adenosyl-L-methionine on liver injury induced by D-galactosamine in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Male; Methionine Adenosyltransferase; Prednisolone; Rats; S-Adenosylmethionine | 1978 |
Effect on vitamin A on the development of galactosamine-induced hepatitis in rats.
Topics: Animals; Carboxypeptidases; Cathepsins; Cell-Free System; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Kupffer Cells; Liver; Lysosomes; Rats; Vitamin A | 1978 |
Dysregulation of protein synthesis in injured liver. A comparative study on microsomal and cytosole enzyme activities, microsomal lipoperoxidation and polysomal pattern in D-galactosamine and carbon tetrachloride-injured livers.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cytosol; Galactosamine; Lipid Metabolism; Liver; Male; Microsomes, Liver; Peroxides; Polyribosomes; Protein Biosynthesis; Rats | 1978 |
Cerebral edema in the rat with galactosamine induced severe hepatitis.
Topics: Animals; Brain Edema; Brain Stem; Cerebellum; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Galactosamine; Rats; Time Factors; Water | 1978 |
Lipoprotein abnormalities in galactosamine hepatitis: a model of experimental lecithin:cholesterol acyltransferase deficiency.
Topics: Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Cholesterol; Cholesterol Esters; Disease Models, Animal; Female; Galactosamine; Hypolipoproteinemias; Lecithin Cholesterol Acyltransferase Deficiency; Lipids; Lipoproteins; Lysophosphatidylcholines; Phosphatidylcholines; Phospholipids; Rats | 1978 |
[Toxicity of ammonium acetate in rats with acute and subacute galactosamine-induced hepatitis (author's transl)].
Topics: Acetates; Animals; Arginine; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Hepatitis; Quaternary Ammonium Compounds; Rats; Urea | 1979 |
[The importance of intestinal endotoxins for the rise of toxic liver lesions from galactosamine].
Topics: Animals; Chemical and Drug Induced Liver Injury; Colectomy; Endotoxins; Escherichia coli; Fever; Galactosamine; Male; Phagocytosis; Rats; Transaminases | 1976 |
Lipoprotein and lecithin: cholesterol acyltransferase changes in galactosamine-induced rat liver injury.
Topics: Acyltransferases; Animals; Apoproteins; Chemical and Drug Induced Liver Injury; Cholesterol Esters; Disease Models, Animal; Female; Galactosamine; Lecithin Cholesterol Acyltransferase Deficiency; Lipid Metabolism, Inborn Errors; Lipoproteins; Liver Diseases; Phosphatidylcholine-Sterol O-Acyltransferase; Rats | 1975 |
Serum level changes of endogenous and postheparin diamine oxidase (histaminase) in clinical and experimental hepatitis.
Topics: Acute Disease; Adolescent; Adult; Alanine Transaminase; Amine Oxidase (Copper-Containing); Animals; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Heparin; Hepatitis; Hepatitis A; Humans; Middle Aged; Rats | 1976 |
[Diaminooxidase (histaminase) in liver diseases and experimental liver lesions].
Topics: Amine Oxidase (Copper-Containing); Animals; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Guinea Pigs; Liver Diseases | 1976 |
Significance of endotoxaemia in experimental "galactosamine-hepatitis" in the rat.
Topics: Animals; Blood Glucose; Blood Pressure; Body Temperature; Chemical and Drug Induced Liver Injury; Colon; Endotoxins; Galactosamine; Kupffer Cells; Leukocyte Count; Liver Function Tests; Male; Phagocytosis; Rats | 1977 |
Behaviour of 125I-fibrinogen and 131I-albumin in experimental galactosamine-induced hepatitis.
Topics: Aminocaproic Acid; Animals; Blood Coagulation; Chemical and Drug Induced Liver Injury; Disseminated Intravascular Coagulation; Female; Fibrinogen; Galactosamine; Heparin; Rabbits; Serum Albumin | 1977 |
[(Blood coagulation disturbances of rats after acute liver damage produced by D-galactosamin-HCl) (author's transl)].
Topics: Animals; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Fibrinolysis; Galactosamine; Hematocrit; Hemostasis; Liver Diseases; Platelet Aggregation; Rats | 1977 |
Light and electron microscopic study of hermorrhagic hepatitis induced by trimethyllysine and D-galactosamine.
Topics: Animals; Cell Division; Chemical and Drug Induced Liver Injury; Disease Models, Animal; DNA; Endoplasmic Reticulum; Galactosamine; Hemorrhage; Hepatitis; Liver Regeneration; Lysine; Mice; Microscopy, Electron; RNA | 1977 |
Protective effects of Alpha-tocopherol on the hepatotoxicity of D-galactosamine.
Topics: Animals; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Liver; Rats; Vitamin E | 1976 |
[The significance of age for morphological and biochemical changes in galactosamine hepatitis].
Topics: Aging; Animals; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Male; Rats; Transaminases | 1976 |
[Advantages and limitations of the galactosamine model].
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Gluconeogenesis; Glycolipids; Glycoproteins; Liver; Rats; RNA; Uracil Nucleotides | 1976 |
[Animal experimental studies on the problem of liver damage by antitubercular agents (rifampicin and isoniazide) by means of the galactosamine model].
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Isoniazid; Liver; Male; Rats; Rifampin | 1976 |
New hepato-protective agents. I. Maleopimaric acid-4alpha-carboxamides.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Lethal Dose 50; Male; Rats; Triterpenes | 1976 |
New hepato-protective agents. II. Maleopimaridyl morpholides.
Topics: Chemical and Drug Induced Liver Injury; Galactosamine; Lethal Dose 50; Morpholines; Triterpenes | 1976 |
The protective effect of a novel compound RU 18492, on galactosamine-induced hepatotoxicity in the rat.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Galactosamine; Male; Morpholines; Rats; Triterpenes | 1976 |
Galactosamine- "hepatitis" in rats with different phagocytic activity of liver RES.
Topics: Animals; Carbon; Chemical and Drug Induced Liver Injury; Galactosamine; Ink; Kupffer Cells; Liver; Mononuclear Phagocyte System; Necrosis; Phagocytosis; Premedication; Rats; Rats, Inbred Strains; Shwartzman Phenomenon; Time Factors | 1975 |
Early, reversible plasma membrane injury in galactosamine-induced liver cell death.
Topics: Animals; Calcium; Cell Membrane; Cell Survival; Chemical and Drug Induced Liver Injury; Circular Dichroism; Copper; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Female; Galactosamine; Liver; Liver Diseases; Molecular Conformation; Nucleotidases; Protein Biosynthesis; Rats; RNA; Time Factors; Uridine | 1975 |
Potentiation of the hepatotoxic responses to chemicals in alloxan-diabetic rats.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Bilirubin; Blood Glucose; Chemical and Drug Induced Liver Injury; Chloroform; Diabetes Mellitus, Experimental; Ethane; Galactosamine; Hydrocarbons, Chlorinated; Insulin; Isocitrate Dehydrogenase; Liver; Male; Rats; Trichloroethylene; Triglycerides | 1975 |
Proceedings: The hepatotoxic effect of ethanol after pretreatment with carbon tetrachloride, allyl alcohol, or D-galactosamine.
Topics: Alcoholic Intoxication; Alcohols; Allyl Compounds; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Drug Synergism; Ethanol; Galactosamine; Guinea Pigs; Humans; Rats | 1975 |
An investigation and some parameters that affect the galactosamine model of hepatitis in the rat.
Topics: Administration, Oral; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Body Weight; Chemical and Drug Induced Liver Injury; Diethylstilbestrol; Disease Models, Animal; Dose-Response Relationship, Drug; Estrus; Female; Galactosamine; Injections, Intraperitoneal; Injections, Subcutaneous; L-Lactate Dehydrogenase; Male; Pregnancy; Rats; Sex Factors; Species Specificity; Time Factors | 1975 |
The biochemical pathology of liver cell necrosis.
Topics: Animals; Calcium; Cell Membrane; Cell Survival; Chemical and Drug Induced Liver Injury; Galactosamine; Humans; Liver; Lysosomes; Mitochondria, Liver; Necrosis; Protein Biosynthesis; Rats; RNA; Uridine | 1975 |
The appearance of D-galactosamine-induced hepatitis and generalized edema in adrenalectomized rats.
Topics: Adrenalectomy; Animals; Ascites; Castration; Chemical and Drug Induced Liver Injury; Edema; Endothelium; Female; Galactosamine; Glucocorticoids; Male; Rats; Sex Factors | 1975 |
Effects of ammonia intoxication and liver injury on rat brain glutamate-dehydrogenase and glutaminase activity.
Topics: Ammonia; Animals; Brain; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Galactosamine; Glutamate Dehydrogenase; Glutaminase; Necrosis; Neurologic Manifestations; Rats | 1975 |
[The effect of silybin-dihemisuccinate on regulation disorders in phospholipid metabolism in acute galactosamine intoxication in the rat].
Topics: Animals; Chemical and Drug Induced Liver Injury; Flavonoids; Galactosamine; Liver; Male; Microsomes, Liver; Mitochondria, Liver; Palmitic Acids; Phosphatidic Acids; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Rats; Silymarin; Triglycerides | 1975 |
Inhibition, by drugs, of galactosamine induced hepatitis in the rat.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Azathioprine; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Galactosamine; Liver; Male; Orotic Acid; Phenobarbital; Prednisolone; Rats | 1975 |
An investigation of the hepatotoxicity of D-galactosamine in different species of animal.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Galactosamine; Liver; Male; Mice; Rats; Species Specificity; Time Factors | 1975 |
Experimental galactosamine-induced hepatitis. Effect of anticoagulant and antifibrinolytic agents on microclot formation.
Topics: Alanine Transaminase; Aminocaproates; Animals; Blood Coagulation; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Disseminated Intravascular Coagulation; Female; Galactosamine; Heparin; Hepatitis; Kidney Cortex Necrosis; Kidney Glomerulus; Liver; Male; Rabbits | 1976 |
Modification of the hepatotoxicity of D-galactosamine in the rat by cycloheximide.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cycloheximide; Galactosamine; Liver; Liver Diseases; Necrosis; Protein Biosynthesis; Rats; Triglycerides | 1976 |
Influence of d-galactosamine hydrochloride on lipids and their fatty acid composition in plasma and liver of guinea pigs.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Fatty Acids; Galactosamine; Linoleic Acids; Linolenic Acids; Lipid Metabolism; Liver; Male; Microsomes, Liver; Oleic Acids; Palmitic Acids; Phosphatidylcholines; Phospholipids; Rats | 1976 |
Protective activity of silipide on liver damage in rodents.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Ethanol; Female; Galactosamine; Male; Phosphatidylcholines; Praseodymium; Rats; Rats, Sprague-Dawley; Rats, Wistar; Silymarin | 1992 |
Ongoing hepatocellular regeneration and resiliency toward galactosamine hepatotoxicity.
Topics: Aging; Alanine Transaminase; Animals; Aspartate Aminotransferases; Autoradiography; Chemical and Drug Induced Liver Injury; DNA; Female; Galactosamine; Liver; Liver Diseases; Liver Glycogen; Liver Regeneration; Male; Necrosis; Pregnancy; Rats; Rats, Sprague-Dawley; Time Factors; Uracil Nucleotides | 1992 |
[The effect of ubiquinone-10 on the development of D-galactosamine-induced hepatitis in rats].
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Evaluation, Preclinical; Galactosamine; Liver; Male; Microscopy, Electron; Rats; Ubiquinone | 1992 |
Arachidonate metabolism in D-galactosamine or carbon tetrachloride-induced acute and chronic liver injuries in rats.
Topics: Acute Disease; Animals; Arachidonic Acids; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chronic Disease; Eicosanoids; Galactosamine; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Lipopolysaccharides; Liver; Liver Cirrhosis, Experimental; Liver Diseases; Male; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Wistar | 1992 |
Experimental studies on the changes of adrenergic receptors in rat liver with acute injury and in endotoxemia.
Topics: Animals; Autoradiography; Catecholamines; Chemical and Drug Induced Liver Injury; Endotoxins; Galactosamine; Liver; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Toxemia | 1992 |
Protective effects of E3330, a novel quinone derivative, on galactosamine/tumor necrosis factor-alpha-induced hepatitis in mice.
Topics: Animals; Ascitic Fluid; Benzoquinones; Chemical and Drug Induced Liver Injury; Dinoprostone; Galactosamine; In Vitro Techniques; Leukotriene B4; Male; Mice; Mice, Inbred C3H; Propionates; Rats; Thromboxane B2; Tumor Necrosis Factor-alpha | 1992 |
[Epidermal growth factor for enhancing DNA synthesis of hepatocytes and its protecting effect on animals with liver injury].
Topics: Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; DNA; Epidermal Growth Factor; Galactosamine; Glucagon; Insulin; Liver; Mice; Rats | 1992 |
Immunohistochemical study of extracellular matrix in acute galactosamine hepatitis in rats.
Topics: Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Collagen; Extracellular Matrix; Fibronectins; Galactosamine; Immunohistochemistry; Laminin; Liver; Male; Necrosis; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Staining and Labeling | 1992 |
Protective effect of zinc on liver injury induced by D-galactosamine in rats.
Topics: Animals; Brain; Cell Separation; Chemical and Drug Induced Liver Injury; Galactosamine; Injections, Intraperitoneal; Liver; Liver Diseases; Liver Function Tests; Male; Rats; Rats, Wistar; Zinc | 1992 |
[Effects of astragalus (ASI, SK) on experimental liver injury].
Topics: Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Galactosamine; Glucosides; Glutathione; Male; Malondialdehyde; Mice; Microsomes, Liver; Rats; Saponins; Triterpenes | 1992 |
[Therapeutic effects of epimeric glycyrrhizic acids on hepatic injury in rats].
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Glycyrrhetinic Acid; Glycyrrhizic Acid; Liver Failure; Male; Putrescine; Rats; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship | 1992 |
Ornithine and histidine decarboxylase activities in mice sensitized to endotoxin, interleukin-1 or tumour necrosis factor by D-galactosamine.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Endotoxins; Enzyme Induction; Female; Galactosamine; Histamine; Histidine Decarboxylase; In Vitro Techniques; Interleukin-1; Kinetics; Liver; Liver Circulation; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine; Spleen; Tumor Necrosis Factor-alpha; Uridine | 1992 |
A link between extracellular reactive oxygen and endotoxin-induced release of tumour necrosis factor alpha in vivo.
Topics: Alanine Transaminase; Allopurinol; Animals; Catalase; Chemical and Drug Induced Liver Injury; Endotoxins; Galactosamine; Liver; Male; Mice; Models, Biological; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 1992 |
Galactosamine induced hepatitis induces a reduction in hepatocyte epidermal growth factor receptors.
Topics: Animals; Cell Membrane; Cells, Cultured; Chemical and Drug Induced Liver Injury; DNA Replication; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Galactosamine; Hepatectomy; Liver; Male; Rats; Rats, Inbred Strains | 1992 |
Involvement of activated polymorphonuclear leukocytes in galactosamine-induced hepatic injury in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Male; Necrosis; Neutrophils; Rats; Rats, Inbred Strains; Superoxides | 1991 |
Hepatic D-galactosamine toxicity studied with localized in vivo 31P magnetic resonance spectroscopy in intact rats.
Topics: Adenosine Triphosphate; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Galactosamine; Liver Diseases; Magnetic Resonance Spectroscopy; Phosphocreatine; Phosphoric Diester Hydrolases; Phosphoric Monoester Hydrolases; Phosphorus; Rats; Rats, Inbred Strains | 1991 |
Pharmacokinetics, neuromuscular effects, and biodisposition of 3-desacetylvecuronium (Org 7268) in cats.
Topics: Animals; Cats; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Kidney Diseases; Liver Diseases; Male; Neuromuscular Blocking Agents; Tissue Distribution; Vecuronium Bromide | 1991 |
Effect of dietary alpha-linolenate/linoleate balance on endotoxin-induced hepatitis in mice.
Topics: alpha-Linolenic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Chemical and Drug Induced Liver Injury; Dietary Fats, Unsaturated; Eicosapentaenoic Acid; Galactosamine; Indomethacin; Linoleic Acid; Linoleic Acids; Linolenic Acids; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Phospholipids | 1991 |
Prevention of galactosamine-induced hepatotoxicity in rats with fructose-1,6-diphosphate.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Blood Glucose; Chemical and Drug Induced Liver Injury; Fructosediphosphates; Galactosamine; gamma-Glutamyltransferase; Injections, Intraperitoneal; Liver; Rats; Rats, Inbred Strains | 1991 |
Effects of intraperitoneal transplantation of microcarrier-attached hepatocytes on D-galactosamine-induced acute liver failure in rats.
Topics: Acute Disease; Albumins; Animals; Bile Acids and Salts; Cells, Cultured; Chemical and Drug Induced Liver Injury; Dextrans; Galactosamine; Liver; Liver Diseases; Liver Transplantation; Male; Microspheres; Peritoneal Cavity; Prealbumin; Rats | 1990 |
Targeted protection of hepatocytes from galactosamine toxicity in vivo.
Topics: alpha-Fetoproteins; Animals; Asialoglycoprotein Receptor; Asialoglycoproteins; Behavior, Animal; Chemical and Drug Induced Liver Injury; Female; Fetuins; Galactosamine; Injections, Intravenous; Iodine Radioisotopes; Liver; Liver Diseases; Polylysine; Rats; Rats, Inbred Strains; Receptors, Immunologic; Uridine Monophosphate | 1990 |
[Protective effects of biphenyl dimethyl dicarboxylate on damage in isolated rat hepatocytes induced by carbon tetrachloride and D-galactosamine].
Topics: Animals; Carbon Tetrachloride Poisoning; Cells, Cultured; Chemical and Drug Induced Liver Injury; Dioxoles; Galactosamine; Liver; Male; Mice; Rats; Rats, Inbred Strains; Ribosomal Proteins; RNA | 1990 |
Histochemical and immunohistochemical study on the expression of alkaline phosphatase, gamma-glutamyl transpeptidase and alpha-fetoprotein during the process of rat hepatocyte proliferation.
Topics: Alkaline Phosphatase; alpha-Fetoproteins; Animals; Biomarkers; Cell Division; Chemical and Drug Induced Liver Injury; Galactosamine; gamma-Glutamyltransferase; Gene Expression Regulation; Liver; Liver Regeneration; Male; Rats; Rats, Inbred Strains; Serum Albumin | 1990 |
Oval cell proliferation and the origin of small hepatocytes in liver injury induced by D-galactosamine.
Topics: alpha-Fetoproteins; Animals; Bile Ducts; Binding Sites; Biomarkers; Cell Division; Chemical and Drug Induced Liver Injury; Galactosamine; Immunohistochemistry; Lectins; Liver; Liver Diseases; Male; Nucleic Acid Hybridization; Peanut Agglutinin; Phenotype; Rats; Rats, Inbred F344; Rats, Inbred Strains; Reference Values | 1991 |
Antihepatotoxic properties of picroliv: an active fraction from rhizomes of Picrorhiza kurrooa.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cinnamates; Galactosamine; Glycosides; India; Liver; Liver Function Tests; Male; Plant Extracts; Plants, Medicinal; Rats; Rats, Inbred Strains; Silymarin; Vanillic Acid | 1991 |
Effects of hepatic stimulatory factor released from free or microencapsulated hepatocytes on galactosamine induced fulminant hepatic failure animal model.
Topics: Animals; Cell-Free System; Cells, Cultured; Chemical and Drug Induced Liver Injury; Disease Models, Animal; DNA; Galactosamine; Growth Inhibitors; Interleukin-6; Leukemia Inhibitory Factor; Liver; Liver Diseases; Liver Regeneration; Lymphokines; Male; Rats; Rats, Inbred Strains; Survival Rate; Thymidine | 1991 |
Physicochemical characteristics of hepatic stimulatory factor prepared from cell free supernatant of hepatocyte cultures.
Topics: Acrylic Resins; Autoradiography; Calibration; Cell-Free System; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chromatography, Gel; Disease Models, Animal; DNA; Galactosamine; Growth Inhibitors; Hot Temperature; Interleukin-6; Leukemia Inhibitory Factor; Liver; Liver Diseases; Liver Regeneration; Lymphokines; Molecular Weight; Proteins; Survival Rate; Thymidine; Trypsin | 1991 |
Interleukin-1 alpha enhances hepatotoxicity of tumor necrosis factor-alpha in galactosamine-sensitized mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Immune Sera; Interleukin-1; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Recombinant Proteins; Tumor Necrosis Factor-alpha | 1991 |
[Protective effect of hepatic stimulator substance against experimental acute liver failure in mice].
Topics: Activating Transcription Factor 3; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; DNA-Binding Proteins; Galactosamine; Glucagon; Insulin; Leucine Zippers; Liver Regeneration; Male; Mice; Rats; Rats, Inbred Strains; Succinate Dehydrogenase | 1991 |
Hepatoprotective effects of 1-[(2-thiazolin-2-yl)-amino]acetyl-4-(1,3-dithiol-2-ylidene)-2,3,4,5- tetrahydro-1H-1-benzazepin-3,5-dione hydrochloride (KF-14363) in various experimental liver injuries.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzazepines; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Ethionine; Galactosamine; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred BALB C; Propionibacterium acnes; Rats; Rats, Inbred Strains; Thiazoles; Triglycerides | 1991 |
Effects of small-intestinal factors on hepatocyte development and modification of chemical agent-induced hepatopathy in rat.
Topics: Animals; Biological Factors; Carbon Tetrachloride; Cell Count; Cells, Cultured; Chemical and Drug Induced Liver Injury; Enzymes; Galactosamine; Intestinal Mucosa; Intestine, Small; Liver; Liver Regeneration; Male; Rats; Rats, Inbred Strains | 1991 |
Bioartificial liver using hepatocytes on biosilon microcarriers: treatment of chemically induced acute hepatic failure in rats.
Topics: Animals; Artificial Organs; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Drug Carriers; Galactosamine; Hemoperfusion; Liver; Male; Polystyrenes; Rats; Rats, Inbred Strains | 1991 |
Endotoxin-inducible cytotoxicity in liver cell cultures--I.
Topics: Animals; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Endotoxins; Galactosamine; Kupffer Cells; L-Lactate Dehydrogenase; Lipopolysaccharides; Liver; Male; Rats; Rats, Inbred Strains; Tumor Necrosis Factor-alpha | 1991 |
Influence of liver damage on antipyrine metabolite formation in rats.
Topics: 1-Naphthylisothiocyanate; Animals; Antipyrine; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Liver Diseases; Male; Rats; Rats, Inbred Strains | 1991 |
Alterations in Fc receptor activity in sinusoidal endothelial cells and Kupffer cells during D-galactosamine (GalN)-induced liver injury in rats. A histological study.
Topics: Animals; Antigen-Antibody Complex; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Immunohistochemistry; Liver; Male; Peroxidase; Rats; Rats, Inbred Strains; Receptors, Fc | 1990 |
Protection by boswellic acids against galactosamine/endotoxin-induced hepatitis in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Endotoxins; Galactosamine; L-Iditol 2-Dehydrogenase; Male; Mice; Plant Extracts; Triterpenes | 1991 |
The protective effects of (4R)-hexahydro-7,7-dimethyl-6-oxo-1,2,5-dithiazocine-4-carboxylic acid (SA3443), a novel cyclic disulfide, on chemically-induced acute liver injury.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Azocines; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disulfides; Ethionine; Galactosamine; Lipid Peroxides; Liver Diseases; Male; Rats; Rats, Inbred Strains; Triglycerides | 1991 |
1H-NMR spectroscopy of biofluids and the investigation of xenobiotic-induced changes in liver biochemistry.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Body Fluids; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Inbred Strains; Xenobiotics | 1990 |
Plasma gamma-aminobutyric acid in experimental fulminant hepatic failure of rats and its diagnostic value in hepatic encephalopathy.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Liver Diseases; Male; Rats; Rats, Inbred Strains | 1990 |
[Protective effect of a platelet activating factor antagonist in experimental liver injury].
Topics: Animals; Azepines; Chemical and Drug Induced Liver Injury; Endotoxins; Galactosamine; Liver; Malondialdehyde; Peroxidase; Platelet Activating Factor; Rats; Rats, Inbred Strains; Superoxide Dismutase; Triazoles | 1990 |
Effects of D-galactosamine-induced acute liver injury on mortality and pulmonary responses to Escherichia coli lipopolysaccharide. Modulation by arachidonic acid metabolites.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Bronchoalveolar Lavage Fluid; Capillary Permeability; Chemical and Drug Induced Liver Injury; Escherichia coli; Galactosamine; Leukotrienes; Lipopolysaccharides; Lung; Male; Rats; Rats, Inbred Strains; Sepsis; Thromboxane B2 | 1990 |
Human hepatic regenerative stimulator substance: partial purification and biological characterization of hepatic stimulator substance from human fetal liver cells.
Topics: Animals; Cell Division; Chemical and Drug Induced Liver Injury; Female; Fetus; Galactosamine; Growth Substances; Hepatectomy; Humans; Liver; Liver Diseases; Liver Regeneration; Male; Mice; Mice, Inbred Strains; Necrosis; Rats; Rats, Inbred Strains | 1990 |
Studies on the hepatotoxicity of galactosamine/endotoxin or galactosamine/TNF in the perfused mouse liver.
Topics: Animals; Chemical and Drug Induced Liver Injury; Endotoxins; Galactosamine; L-Lactate Dehydrogenase; Male; Mice; Perfusion; Salmonella; Time Factors; Tumor Necrosis Factor-alpha; Uridine | 1990 |
Role of endotoxin-responsive macrophages in hepatic injury.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Endotoxins; Free Radicals; Galactosamine; Liver; Macrophage Activation; Macrophages; Mice; Mice, Inbred Strains; Oxygen; Spleen; Superoxide Dismutase | 1990 |
[31P nuclear magnetic resonance study of intrahepatic energy metabolism in acute liver failure].
Topics: Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Energy Metabolism; Galactosamine; Hydrogen-Ion Concentration; Liver; Liver Diseases; Magnetic Resonance Spectroscopy; Male; Phosphorus; Rats; Rats, Inbred Strains | 1990 |
Immunopathology of acute galactosamine hepatitis in rats.
Topics: Acute Disease; Animals; Antibodies, Monoclonal; Chemical and Drug Induced Liver Injury; Galactosamine; Immunohistochemistry; Liver; Liver Regeneration; Macrophages; Male; Necrosis; Rats; Rats, Inbred Strains; T-Lymphocytes, Cytotoxic | 1990 |
Hepatic uptake and antihepatotoxic properties of vitamin E and liposomes in the mouse.
Topics: Acetaminophen; Animals; Benzo(a)pyrene; Chemical and Drug Induced Liver Injury; Drug Carriers; Galactosamine; Lipopolysaccharides; Liposomes; Liver; Male; Mice; Phosphatidylcholines; Vitamin E | 1990 |
Effects of putrescine on D-galactosamine-induced acute liver failure in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Liver Diseases; Liver Regeneration; Male; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Survival Analysis; Thymidine | 1990 |
[Use of hepatocytes cultured in microcarriers for correction of acute hepatic insufficiency].
Topics: Acute Disease; Albumins; Animals; Bilirubin; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Culture Media; Galactosamine; Liver; Liver Diseases; Male; Microscopy, Electron, Scanning; Polystyrenes; Rats; Rats, Inbred Strains; Time Factors | 1990 |
Leukocyte alterations do not account for hepatitis induced by endotoxin or TNF alpha in galactosamine-sensitized mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Endotoxins; Galactosamine; Immune Sera; Leukocyte Count; Lipopolysaccharides; Male; Mice; Salmonella; Tumor Necrosis Factor-alpha | 1990 |
[Hepatocyte transplantation - development of a clinical model].
Topics: Animals; Cell Separation; Cell Survival; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Histocytochemistry; Injections; Injections, Intraperitoneal; Liver; Liver Diseases; Liver Transplantation; Rats; Rats, Inbred Strains; Spleen; Swine; Transplantation | 1987 |
Cellular analysis of alpha-fetoprotein gene activation during carbon tetrachloride and D-galactosamine-induced acute liver injury in rats.
Topics: alpha-Fetoproteins; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Galactosamine; Gene Expression Regulation; Liver Regeneration; Male; Mitotic Index; Nucleic Acid Hybridization; Rats; RNA, Messenger; Transcriptional Activation | 1988 |
Tryptophan metabolism in D-galactosamine-induced liver injury.
Topics: Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Galactosamine; Hydroxyindoleacetic Acid; Indoleacetic Acids; Liver; Liver Diseases; Rats; Rats, Inbred Strains; Serotonin; Tryptamines; Tryptophan | 1988 |
Tumor necrosis factor is a terminal mediator in galactosamine/endotoxin-induced hepatitis in mice.
Topics: Allopurinol; Animals; Chemical and Drug Induced Liver Injury; Eicosanoic Acids; Endotoxins; Epoprostenol; Galactosamine; Iloprost; Imidazoles; Male; Mice; Mice, Inbred Strains; Nifedipine; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Verapamil; Xanthine Oxidase | 1989 |
MRI measurement of hepatocyte toxicity using the new MRI contrast agent manganese dipyridoxal diphosphate, a manganese/pyridoxal 5-phosphate chelate.
Topics: Animals; Chemical and Drug Induced Liver Injury; Contrast Media; Edetic Acid; Ethanol; Galactosamine; Liver; Liver Diseases; Magnetic Resonance Imaging; Manganese; Pyridoxal Phosphate; Rabbits; Time Factors | 1989 |
[Pharmacological effects of reiousan on experimental hepatic injuries and hepatic functions].
Topics: 1-Naphthylisothiocyanate; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Ethanol; Galactosamine; Guinea Pigs; Liver Circulation; Male; Rats; Rats, Inbred Strains; Superoxides | 1989 |
[Protective effects of DBcAMP on acute liver failure induced by D-galactosamine in rats].
Topics: Acute Disease; Adenosine Triphosphate; Animals; Blood Glucose; Bucladesine; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Liver Circulation; Liver Diseases; Liver Function Tests; Male; Necrosis; Rats; Rats, Inbred Strains | 1989 |
Production of leukotriene B4 in parenchymal and sinusoidal cells of the liver in rats treated simultaneously with D-galactosamine and endotoxin.
Topics: Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Endotoxins; Galactosamine; Leukotriene B4; Lipopolysaccharides; Liver; Liver Diseases; Male; Rats; Salmonella enteritidis | 1989 |
Colchicine prevents D-galactosamine-induced hepatitis.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Calcium; Calcium-Transporting ATPases; Chemical and Drug Induced Liver Injury; Colchicine; Disease Models, Animal; Galactosamine; gamma-Glutamyltransferase; Glycogen; Lipid Peroxidation; Liver; Male; Rats; Rats, Inbred Strains | 1989 |
Effect of D-galactosamine on blood clearance of 99mTc-phytate in dogs.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Dogs; Female; Galactosamine; Hyperbilirubinemia; Liver Function Tests; Male; Organotechnetium Compounds; Phytic Acid | 1989 |
Fetal liver allo- and xenotransplantation in acute and chronic hepatic failure.
Topics: Acute Disease; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chronic Disease; Fetus; Freezing; Galactosamine; Liver; Liver Diseases; Liver Transplantation; Rats; Rats, Inbred Lew; Swine; Transplantation, Heterologous; Transplantation, Homologous | 1989 |
Decrease in the number of receptors for epidermal growth factor in the liver of D-galactosamine-intoxicated rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Epidermal Growth Factor; ErbB Receptors; Galactosamine; Indicator Dilution Techniques; Liver; Liver Diseases; Male; Rats; Rats, Inbred Strains | 1989 |
Marked increase of HGF mRNA in non-parenchymal liver cells of rats treated with hepatotoxins.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA Probes; Galactosamine; Interleukin-6; Kinetics; Liver; Liver Regeneration; Nucleic Acid Hybridization; Proteins; Rats; RNA, Messenger | 1989 |
Expression of tumor necrosis factor-alpha and transforming growth factor-beta 1 in acute liver injury.
Topics: Acute Disease; Animals; Blotting, Northern; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Immunoenzyme Techniques; Male; Rats; Rats, Inbred Strains; RNA, Messenger; Transcription, Genetic; Transforming Growth Factors; Tumor Necrosis Factor-alpha | 1989 |
Effect of hepatic failure toxins on regenerative enzymes in the liver after injury with galactosamine in the rat.
Topics: Acetaminophen; Ammonium Chloride; Animals; Caprylates; Chemical and Drug Induced Liver Injury; Disulfides; Galactosamine; Hepatic Encephalopathy; Liver Diseases; Liver Regeneration; Male; Ornithine Decarboxylase Inhibitors; Rats; Rats, Inbred Strains; Thymidine Kinase; Time Factors | 1989 |
Treatment of chronic liver injury in mice by oral administration of xiao-chai-hu-tang.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chronic Disease; Drugs, Chinese Herbal; Galactosamine; Hydroxyproline; Liver; Male; Mice; Mice, Inbred Strains; Prothrombin Time | 1989 |
[Role of singlet oxygen in pathogenesis of liver injury in rats treated with D-galactosamine].
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Lipid Peroxidation; Liver; Liver Diseases; Luminescent Measurements; Male; Necrosis; Oxygen; Rats; Rats, Inbred Strains; Singlet Oxygen; Vitamin E | 1989 |
[Studies on the effect of liver cytosol on experimental acute hepatic failure in the rat].
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytosol; Dogs; Fetus; Galactosamine; Humans; Liver; Liver Diseases; Liver Regeneration; Male; Rats; Rats, Inbred Strains | 1989 |
Regenerative enzyme activity of the liver after partial hepatectomy or toxic injury depressed by continuous NH4+ infusion.
Topics: Acetaminophen; Ammonia; Ammonium Chloride; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Hepatectomy; Liver; Liver Regeneration; Male; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Rats; Rats, Inbred Strains; Thymidine Kinase | 1989 |
Relation between blood clearance and hepatic uptake of 99mTc-phytate in rats with hepatic injury.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Ethionine; Galactosamine; Male; Organotechnetium Compounds; Phytic Acid; Radionuclide Imaging; Rats; Rats, Inbred Strains | 1989 |
Changes in endogenous prostaglandin levels during D-galactosamine-induced liver injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Galactosamine; Indomethacin; Liver Diseases; Male; Necrosis; Prostaglandins; Rats; Rats, Inbred Strains | 1989 |
Leukotriene-mediated liver injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Endotoxins; Galactosamine; Glutathione; Isoxazoles; Leukotriene E4; Liver; Male; Mice; SRS-A | 1988 |
Toxicity of D-galactosamine for rat hepatocytes in monolayer culture.
Topics: Albumins; Animals; Calcium; Calmodulin; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Dexamethasone; Endotoxins; Female; Galactosamine; gamma-Glutamyltransferase; L-Lactate Dehydrogenase; Liver; Rats; Rats, Inbred Strains; Triiodothyronine; Uridine Triphosphate | 1985 |
Influence of somatostatin on galactosamine-induced liver injury.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Liver Diseases; Male; Octreotide; Rats; Somatostatin | 1986 |
[Effects of preliminary fasting on the development of D-galactosamine-induced acute lesion of the liver in rats].
Topics: Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Fasting; Galactosamine; Glutarates; Glutathione; Hyperplasia; Hypertrophy; Liver; Male; Necrosis; Rats; Rats, Inbred Strains | 1989 |
An ultrastructural and histochemical study of the prominent inflammatory response in D(+)-galactosamine hepatotoxicity.
Topics: Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Inflammation; Lectins; Liver; Male; Microscopy, Electron; Monocytes; Neutrophils; Peanut Agglutinin; Rats; Rats, Inbred Strains | 1987 |
The effect of nonviral liver damage on the T-lymphocyte helper/suppressor ratio.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Leukocyte Count; Necrosis; Orotic Acid; Rats; T-Lymphocytes; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory | 1988 |
[Pharmacological studies on schizandra fruits. III. Effects of wuweizisu C, a lignan component of schizandra fruits, on experimental liver injuries in rats].
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cyclooctanes; Ethionine; Fatty Liver; Galactosamine; Hepatitis; Lignans; Liver Diseases; Male; Plant Extracts; Plants, Medicinal; Polycyclic Compounds; Rats; Rats, Inbred Strains | 1985 |
[Cyclic AMP- and ATP-mediated stimulation of DNA synthesis following partial hepatectomy by prostaglandin-E1 in D-galactosamine injured liver].
Topics: Adenosine Triphosphate; Alanine Transaminase; Alprostadil; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cyclic AMP; DNA; Galactosamine; Hepatectomy; Liver; Liver Circulation; Liver Regeneration; Male; Rats; Rats, Inbred Strains | 1985 |
Superoxide anion generating capacity and lysosomal enzyme activities of Kupffer cells in galactosamine induced hepatitis.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Glucuronidase; Hepatitis, Animal; Kupffer Cells; Lipopolysaccharides; Luminescent Measurements; Lysosomes; Mononuclear Phagocyte System; Neutrophils; Phagocytosis; Polymyxin B; Rats; Superoxides | 1986 |
[Effects of DBcAMP on galactosamine-induced acute liver failure].
Topics: Acute Disease; Animals; Bucladesine; Chemical and Drug Induced Liver Injury; Galactosamine; Male; Rats; Rats, Inbred Strains | 1986 |
Reduced brain Na+, K+-ATPase activity in rats with galactosamine-induced hepatic failure: relationship to encephalopathy and cerebral oedema.
Topics: Acute Disease; Animals; Brain; Brain Edema; Chemical and Drug Induced Liver Injury; Galactosamine; Hepatic Encephalopathy; Male; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase | 1987 |
Biochemical effects of acute stress on energy metabolism in liver damaged rats.
Topics: Acetyl Coenzyme A; Animals; Chemical and Drug Induced Liver Injury; Cyclic AMP; Cyclic GMP; Energy Metabolism; Galactosamine; Ketone Bodies; Lactates; Lactic Acid; Liver Diseases; Male; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Stress, Physiological | 1987 |
Renin-angiotensin system, blood pressure homeostasis and renal function in galactosamine-induced fulminant hepatic failure in the guinea pig.
Topics: Angiotensinogen; Animals; Blood Pressure; Chemical and Drug Induced Liver Injury; Galactosamine; Guinea Pigs; Homeostasis; Kidney; Liver Diseases; Male; Renin; Renin-Angiotensin System | 1988 |
Microencapsulated hepatocytes for bioartificial liver support.
Topics: Albumins; Animals; Artificial Organs; Cell Survival; Chemical and Drug Induced Liver Injury; Drug Compounding; Electrophoresis, Polyacrylamide Gel; Galactosamine; Liver; Liver Diseases; Liver Transplantation; Male; Rats; Rats, Inbred Strains | 1988 |
Effect of hypometabolism on cell injury.
Topics: Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Galactosamine; Humans; L-Lactate Dehydrogenase; Liver; Myocardial Infarction; Rats; Thyroid Hormones; Thyroidectomy; Thyrotropin; Thyrotropin-Releasing Hormone; Time Factors | 1986 |
[Pathogenic significance of endotoxemia in acute experimental liver failure].
Topics: Animals; Chemical and Drug Induced Liver Injury; Endotoxins; Galactosamine; Liver; Male; Rats; Rats, Inbred Strains; Toxemia | 1988 |
Kinetic analysis of phenytoin disposition in rats with experimental renal and hepatic diseases.
Topics: Acute Kidney Injury; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Male; Models, Biological; Phenytoin; Rats; Rats, Inbred Strains; Tissue Distribution; Uranyl Nitrate | 1988 |
[Protective effect of Polyporus umbellatus polysaccharide on toxic hepatitis in mice].
Topics: Animals; Basidiomycota; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Galactosamine; Male; Mice; Polyporaceae; Polysaccharides | 1988 |
[Relation of serum glutathione S-transferase activity and pathologic abnormalities of the liver].
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Glutathione Transferase; Hepatitis, Viral, Animal; Hepatitis, Viral, Human; Humans; Liver; Necrosis; Rabbits | 1988 |
Dynamic relationship between urea and glutamine synthesis in the mechanism of ammonia detoxication: a tracer study using 15NH4Cl in fulminant hepatic failure rats.
Topics: Ammonia; Ammonium Chloride; Animals; Blood Urea Nitrogen; Chemical and Drug Induced Liver Injury; Galactosamine; Glutamine; Liver Diseases; Male; Nitrogen Isotopes; Rats; Rats, Inbred Strains; Urea | 1988 |
[Evaluation of serum cathepsin B-like activity in liver diseases].
Topics: Animals; Carbon Tetrachloride; Cathepsin B; Chemical and Drug Induced Liver Injury; Galactosamine; Humans; Liver Diseases; Male; Rats; Rats, Inbred Strains | 1988 |
Reversal of liver failure in rats by ultraviolet-irradiated hepatocyte transplantation.
Topics: Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Liver Diseases; Liver Regeneration; Liver Transplantation; Rats; Rats, Inbred WF; Transplantation, Heterotopic; Transplantation, Homologous | 1987 |
Partial purification and characterization of hepatocyte proliferation stimulatory factor from liver of rats treated with D-galactosamine.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chemical Precipitation; Chromatography; Dialysis; DNA; Epidermal Growth Factor; Galactosamine; Growth Substances; Hot Temperature; Hydrogen-Ion Concentration; Insulin; Liver; Liver Diseases; Male; Rats; Rats, Inbred Strains; Trypsin | 1988 |
Experimental studies on the effect of hepatoprotective compounds.
Topics: Aminoimidazole Carboxamide; Animals; Carbon Tetrachloride Poisoning; Catechin; Chemical and Drug Induced Liver Injury; Epoprostenol; Flavonoids; Galactosamine; Imidazoles; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Rats; Rats, Inbred F344; Ribonucleosides; Silymarin | 1986 |
Contribution of hepatic reticuloendothelial system to glomerular IgA deposition in rat liver injury.
Topics: Alanine Transaminase; Animals; Carbon; Chemical and Drug Induced Liver Injury; Chemical Fractionation; Dimethylnitrosamine; Galactosamine; Immunoglobulin A; Kidney Glomerulus; Liver; Liver Diseases; Male; Molecular Weight; Mononuclear Phagocyte System; Rats; Rats, Inbred Strains | 1988 |
[Effect of putrescine on experimental acute hepatic injury in rats].
Topics: Animals; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Liver; Liver Diseases; Putrescine; Rats; Rats, Inbred Strains | 1988 |
Protective effect of malotilate against galactosamine intoxication in the rat.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Liver Diseases; Liver Function Tests; Male; Malonates; Rats; Rats, Inbred Strains | 1987 |
Effects of methyl (+)(3S)-1,2,3,4-tetrahydro-3-hydroxy-methyl-beta-carboline-2- carbodithioate (THC), a new hepatoprotective agent, on acute liver injuries induced by various hepatotoxic substances in mice and rats.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bromobenzenes; Carbolines; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Galactosamine; In Vitro Techniques; Lipid Peroxides; Male; Mice; Rats; Rats, Inbred Strains; Species Specificity; Triglycerides | 1987 |
Quantitative and qualitative changes of serum proteolytic activity in rats with liver damage induced by galactosamine.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chromatography, Gel; Galactosamine; Iodine Radioisotopes; Liver; Male; Peptide Hydrolases; Protease Inhibitors; Rats | 1986 |
[Prostacyclin and other drugs protective against experimental liver damage in rats].
Topics: Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Drug Synergism; Epoprostenol; Female; Galactosamine; Liver Diseases; Male; Neostigmine; Prostaglandins F; Rats; Rats, Inbred Strains; Solanaceous Alkaloids | 1986 |
D-galactosamine-induced liver injury in mice fed on a diet of different protein content.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dietary Proteins; Galactosamine; Male; Mice; Mice, Inbred C3H | 1987 |
Leukotriene D4 mediates galactosamine/endotoxin-induced hepatitis in mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Interactions; Endotoxins; Galactosamine; Hepatitis, Animal; Male; Mice; SRS-A | 1987 |
[Favorable action of preliminary fasting on changes in liver plasma membrane enzymes due to the use of D-galactosamine].
Topics: Animals; Cell Membrane; Chemical and Drug Induced Liver Injury; Fasting; Galactosamine; Liver; Male; Rats; Rats, Inbred Strains; Time Factors | 1987 |
Protection by ebselen against endotoxin shock in rats or mice sensitized by galactosamine.
Topics: Animals; Azoles; Chemical and Drug Induced Liver Injury; Fatty Acids, Unsaturated; Galactosamine; Glutathione; Hemodynamics; Isoindoles; Liver; Male; Mice; Organoselenium Compounds; Rats; Rats, Inbred Strains; Selenium; Shock, Septic | 1987 |
Copper protects against galactosamine-induced hepatitis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Copper; Feces; Galactosamine; Ornithine Carbamoyltransferase | 1987 |
[Effects of gomisin A, a lignan component of Schizandra fruits, on experimental liver injuries and liver microsomal drug-metabolizing enzymes].
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Ethionine; Galactosamine; Lignans; Liver Diseases; Male; Microsomes, Liver; Mixed Function Oxygenases; Protein Biosynthesis; Rats; Rats, Inbred Strains; Sleep | 1986 |
[Galactosamine-induced acute liver failure in the guinea pig--spontaneous course and controlled study conditions].
Topics: Acute Disease; Animals; Blood Glucose; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Galactosamine; Guinea Pigs; Hepatic Encephalopathy; Liver; Liver Function Tests; Male; Necrosis | 1986 |
A novel biologically active seleno-organic compound--VI. Protection by ebselen (PZ 51) against galactosamine/endotoxin-induced hepatitis in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Azoles; Chemical and Drug Induced Liver Injury; Dexamethasone; Diethylcarbamazine; Endotoxins; Galactosamine; Glutathione; Glutathione Disulfide; Hepatitis, Animal; Ibuprofen; Indomethacin; Isoindoles; L-Iditol 2-Dehydrogenase; Male; Mice; Organoselenium Compounds; Selenium; Time Factors | 1986 |
Antihepatotoxic actions of Allium sativum bulbs.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Galactosamine; Garlic; Male; Microsomes, Liver; Plant Extracts; Plants, Medicinal; Rats; Rats, Inbred Strains | 1986 |
Brain edema in rabbits with galactosamine-induced fulminant hepatitis. Regional differences and effects on intracranial pressure.
Topics: Animals; Body Water; Brain Edema; Cerebellum; Cerebral Cortex; Chemical and Drug Induced Liver Injury; Galactosamine; Hippocampus; Intracranial Pressure; Male; Mesencephalon; Pons; Rabbits | 1986 |
Membrane lipid changes in erythrocytes, liver and kidney in acute and chronic experimental liver disease in rats.
Topics: Acute Disease; Animals; Bile Ducts; Cell Membrane; Chemical and Drug Induced Liver Injury; Cholesterol; Chronic Disease; Erythrocyte Membrane; Galactosamine; Hepatitis; Kidney Cortex; Liver; Liver Diseases; Male; Membrane Lipids; Microsomes; Microsomes, Liver; Microvilli; Phospholipids; Rats; Rats, Inbred Strains; Triglycerides | 1987 |
[Experimental study on the role of endotoxin in the mechanism of galactosamine-induced liver injury].
Topics: Animals; Chemical and Drug Induced Liver Injury; Endotoxins; Galactosamine; Liver; Liver Diseases; Male; Mitochondria, Liver; Necrosis; Oxygen Consumption; Rats; Rats, Inbred Strains | 1986 |
Enzymatic defence against oxygen toxicity in D-galactosamine-induced hepatitis in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Lipid Peroxides; Liver; Male; Oxidation-Reduction; Oxygen; Rats; Rats, Inbred Strains | 1985 |
Effect of viable isolated hepatocytes or hepatocyte fractions on survival rate following galactosamine-induced acute liver failure.
Topics: Acute Disease; Animals; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Liver Diseases; Liver Transplantation; Male; Rats; Rats, Inbred BN; Rats, Inbred Strains | 1985 |
Metabolism of branched-chain amino acids in rats with acute hepatic failure: a tracer study using 15N-leucine.
Topics: Alanine; Amino Acids, Branched-Chain; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Glucagon; Glutamine; Insulin; Isoleucine; Leucine; Liver Diseases; Male; Rats; Rats, Inbred Strains; Valine | 1985 |
Experimental studies of transplantation and regeneration of endocrine pancreatic cells.
Topics: Animals; Carbon Tetrachloride Poisoning; Cell Division; Chemical and Drug Induced Liver Injury; Cyclosporins; Galactosamine; Islets of Langerhans; Islets of Langerhans Transplantation; Kidney; Mice; Mice, Obese; Regeneration; Spleen; Stimulation, Chemical | 1985 |
[Substance-induced liver injury as a model for evaluating hepatoprotective drugs].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Evaluation, Preclinical; Galactosamine; Liver Diseases; Rabbits; Rats; Rats, Inbred Strains; Thioacetamide | 1985 |
Effects of regenerating liver cytosol on drug-induced hepatic failure.
Topics: Animals; Bilirubin; Blood Glucose; Chemical and Drug Induced Liver Injury; Cytosol; Disease Models, Animal; DNA; Dose-Response Relationship, Drug; Fat Emulsions, Intravenous; Galactosamine; Hepatectomy; Liver Diseases; Liver Regeneration; Male; Mononuclear Phagocyte System; Rats; Rats, Inbred Strains | 1985 |
The effect of acute liver damage on circulating ferritin levels in vivo and in the isolated perfused rat liver.
Topics: Animals; Chemical and Drug Induced Liver Injury; Ferritins; Galactosamine; In Vitro Techniques; Leucine; Liver; Liver Diseases; Male; Phagocytosis; Protein Biosynthesis; Rats; Rats, Inbred Strains | 1985 |
Antinecrotic effect of 3-palmitoyl-(+)-catechin against liver damage induced by galactosamine or ethanol in the rat.
Topics: Animals; Benzopyrans; Catechin; Chemical and Drug Induced Liver Injury; Ethanol; Galactosamine; Hypoxia; Liver Diseases; Male; Necrosis; Rats; Rats, Inbred Strains | 1985 |
D-galactosamine-induced liver injury: a rat model to study the heterogeneity of the oligosaccharide chains of alpha 1-acid glycoprotein.
Topics: Animals; Chemical and Drug Induced Liver Injury; Concanavalin A; Disease Models, Animal; Galactosamine; Immunoelectrophoresis, Two-Dimensional; Male; Oligosaccharides; Orosomucoid; Rats; Rats, Inbred Strains; Sialic Acids; Time Factors | 1985 |
Antihepatotoxic actions of ginsenosides from Panax ginseng roots.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Galactosamine; Ginsenosides; Panax; Plants, Medicinal; Rats; Saponins | 1985 |
Alternations of liver pathophysiology in experimental hepatic failure treated by two forms of plasma purification procedure.
Topics: Adenine Nucleotides; Animals; Chemical and Drug Induced Liver Injury; Cross Circulation; Galactosamine; Hemoperfusion; Liver Diseases; Liver Function Tests; Male; Mitochondria, Liver; Parabiosis; Rats | 1985 |
[Experimental research on the hepatoprotective activity of drug combinations].
Topics: Acetaminophen; Amino Acids; Animals; Catechin; Chemical and Drug Induced Liver Injury; Drug Combinations; Drug Evaluation, Preclinical; Drug Synergism; Galactosamine; Liver; Male; Piracetam; Rats; Rats, Inbred Strains; Vitamins | 1985 |
Structural requirements for cytoprotective agents in galactosamine-induced hepatic necrosis.
Topics: Animals; Calcium; Chelating Agents; Chemical and Drug Induced Liver Injury; Cystamine; Cysteamine; Galactosamine; Liver Diseases; Male; Necrosis; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1985 |
Effects of gomisin A on liver functions in hepatotoxic chemicals-treated rats.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Galactosamine; Indocyanine Green; Lignans; Liver; Liver Function Tests; Male; Orotic Acid; Polycyclic Compounds; Rats; Rats, Inbred Strains | 1985 |
Antihepatotoxic actions of tannins.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride Poisoning; Cells, Cultured; Chemical and Drug Induced Liver Injury; Galactosamine; Rats; Tannins | 1985 |
Antihepatotoxic actions of gingerols and diarylheptanoids.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride Poisoning; Catechols; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Fatty Alcohols; Galactosamine; Heptanes; Plants, Medicinal; Rats | 1985 |
Antihepatotoxic principles of Phyllanthus niruri herbs.
Topics: Animals; Carbon Tetrachloride Poisoning; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Galactosamine; Lignans; Plant Extracts; Plants, Medicinal; Rats | 1985 |
[Assessment of microsomal functional mass by the aminopyrine breath test in the rat with D-galactosamine injured liver followed by partial hepatectomy].
Topics: Aminopyrine; Animals; Breath Tests; Chemical and Drug Induced Liver Injury; Galactosamine; Hepatectomy; Liver Regeneration; Male; Microsomes, Liver; Rats; Rats, Inbred Strains | 1985 |
Ultrastructural study of liver cell injury due to UTP deficiency.
Topics: Animals; Azauridine; Cell Nucleolus; Chemical and Drug Induced Liver Injury; Cytoplasm; Endoplasmic Reticulum; Female; Galactosamine; Galactose; Golgi Apparatus; Injections, Intraperitoneal; Liver; Liver Diseases; Microscopy, Electron; Mitochondria; Rats; Ribosomes; Time Factors; Uracil Nucleotides; Uridine | 1974 |
[Undesirable metabolic effects following the administration of larger doses of fructose and sorbitol].
Topics: Acute Disease; Adenosine Triphosphate; Animals; Chemical and Drug Induced Liver Injury; Drug Interactions; Energy Metabolism; Fructose; Galactosamine; Hepatitis; Humans; Liver; Parenteral Nutrition; Rats; Sorbitol; Uric Acid | 1974 |
[Enzyme histochemical findings in the rat liver following galactosamine lesions and cholinorotate].
Topics: Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Chemical and Drug Induced Liver Injury; Choline; Galactosamine; Hepatitis A; Histocytochemistry; Humans; Liver Diseases; Orotic Acid; Rats; Succinate Dehydrogenase | 1972 |
[Liver tissue enzymes in rats with galactosamine hepatitis during simultaneous administration of choline-orotate].
Topics: Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Chemical and Drug Induced Liver Injury; Choline; Disease Models, Animal; Galactosamine; Hepatitis; Orotic Acid; Rats | 1973 |
[Studies on the behavior of microsomal enzymes in the rat liver following galactosamine administration].
Topics: Aminopyrine N-Demethylase; Animals; Chemical and Drug Induced Liver Injury; Cytochromes; Disease Models, Animal; Galactosamine; Glucose-6-Phosphatase; Male; Microsomes, Liver; Rats | 1971 |
[Effect of essential phospholipids on the galactosamine hepatitis in rats].
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Phospholipids; Rats | 1974 |
Influence of liver-RES on toxic liver damage due to galactosamine.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Blood Coagulation Factors; Blood Platelets; Blood Proteins; Chemical and Drug Induced Liver Injury; Cholesterol; Disease Models, Animal; Fibrinogen; Galactosamine; Hemolysis; Male; Mononuclear Phagocyte System; Phagocytosis; Rats | 1974 |
[Behavior of 125-I-fibrinogen and 131-I-albumin in experimental galactosamine hepatitis].
Topics: Animals; Blood Coagulation Disorders; Blood Coagulation Factors; Chemical and Drug Induced Liver Injury; Fibrinogen; Galactosamine; Iodine Radioisotopes; Rabbits; Serum Albumin, Radio-Iodinated | 1974 |
[Proceedings: Inhibition of autophagocytosis through cycloheximide in rat hepatocytes damaged by D-galactosamine].
Topics: Animals; Chemical and Drug Induced Liver Injury; Cycloheximide; Galactosamine; Liver; Phagocytosis; Rats | 1974 |
[The incorporation of essential phospholipids into the organs of intact and galactosamine intoxicated rats].
Topics: Animals; Carbon Dioxide; Carbon Radioisotopes; Cardiolipins; Chemical and Drug Induced Liver Injury; Chromatography; Chromatography, Gas; Chromatography, Thin Layer; Fatty Acids, Essential; Galactosamine; Hydrolysis; Injections, Intravenous; Isotope Labeling; Liver; Magnetic Resonance Spectroscopy; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipases; Phospholipids; Rats; Tritium | 1974 |
[Antihepatotoxic influence of silymarin on galactosamine hepatitis in the rat].
Topics: Alanine Transaminase; Alcohols; Animals; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Flavonoids; Galactosamine; L-Lactate Dehydrogenase; Liver; Prothrombin Time; Rats; Succinate Dehydrogenase | 1972 |
[Relationship between lecithin-lysolecithin and cholesterol-cholesterol esters in the serum of the rat with galactosamine-induced hepatosis].
Topics: Acute Disease; Acyltransferases; Animals; Chemical and Drug Induced Liver Injury; Cholesterol; Esters; Galactosamine; Injections, Intraperitoneal; Liver; Liver Diseases; Lysophosphatidylcholines; Male; Phosphatidylcholines; Rats; Time Factors | 1972 |
Different stimuli to disseminated intravascular coagulation in liver diseases.
Topics: Animals; Cardiac Output; Chemical and Drug Induced Liver Injury; Constriction; Disseminated Intravascular Coagulation; Galactosamine; Hypertension, Portal; Liver Circulation; Liver Cirrhosis; Microcirculation; Portal Vein; Rats; Splanchnic Nerves | 1972 |
[Prevention of galactosamine hepatitis using administration of D-galactose: significance of temporally limited UDP-galactose deficit for the induction of galactosamine hepatitis].
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Galactose; Injections; Rats; Time Factors; Uridine Diphosphate Sugars | 1972 |
Metabolic studies in experimental liver disease resulting from D(+)-galactosamine administration.
Topics: Acetoacetates; Alanine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Aspartic Acid; Carboxy-Lyases; Chemical and Drug Induced Liver Injury; Galactosamine; Glucose; Glutamates; Hydroxybutyrates; Ketone Bodies; Lactates; Liver; Male; Pyruvates; Rats | 1972 |
[Significance of enzyme activity in pyrimidine biosynthesis for the development of galactosamine liver lesions].
Topics: Animals; Chemical and Drug Induced Liver Injury; Enzymes; Galactosamine; Liver; Pyrimidines; Rats | 1972 |
[Function of lysosomal enzymes in galactosamine hepatitis].
Topics: Animals; Carboxypeptidases; Cell Membrane; Chemical and Drug Induced Liver Injury; Galactosamine; Lysosomes; Rats | 1972 |
[Influence of bilateral adrenalectomy on acute galactosamine lesions in the rat].
Topics: Adrenal Glands; Adrenalectomy; Animals; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Rats | 1972 |
[Study on di-L(+)-ornithine-alpha-ketoglutaric acid in the model of isolated perfused rat liver].
Topics: Ammonia; Animals; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Glucose; Ketoglutaric Acids; Liver; Membranes; Models, Biological; Ornithine; Perfusion; Potassium; Rats; Urea | 1972 |
Glucose tolerance and blood metabolite changes in galactosamine hepatitis and obstructive jaundice in the rat.
Topics: Animals; Bile Ducts; Blood Glucose; Chemical and Drug Induced Liver Injury; Cholestasis; Galactosamine; Gluconeogenesis; Glucose Tolerance Test; Insulin; Ketone Bodies; Lactates; Ligation; Male; Pyruvates; Rats | 1973 |
D-galactosamine and acute liver cell injury.
Topics: Animals; Cell Nucleolus; Cell Nucleus; Centrifugation; Chemical and Drug Induced Liver Injury; DNA-Directed RNA Polymerases; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Female; Galactosamine; Glycoproteins; Guinea Pigs; Hexosamines; Liver; Mice; Microscopy, Electron; Necrosis; Protein Biosynthesis; Rabbits; Rats; Ribosomes; RNA; Uracil Nucleotides; Uridine; Uridine Diphosphate Sugars | 1973 |
The effect of galactosamine on the activity of lysosomal peptidehydrolases of the liver depending on the age of rats.
Topics: Aging; Animals; Carboxypeptidases; Cathepsins; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Liver; Lysosomes; Peptide Hydrolases; Proteins; Rats; Time Factors | 1973 |
[Galactosamine-hepatitis and anit-cholestasis. Liver damage caused by D-galactosamine-hydrochloride and 1-naphthyl-isothiocyanate (anit)].
Topics: Animals; Animals, Newborn; Body Weight; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Fetus; Galactosamine; Hepatitis A; Humans; Liver; Organ Size; Pregnancy; Rats; Thiocyanates | 1973 |
Ultrastructural studies on D-galactosamine-HCl-induced liver injury in mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chlorides; Female; Galactosamine; Liver; Mice | 1973 |
Stimulation of rat kidney phosphoenolpyruvate carboxykinase activity in experimental liver disease induced by galactosamine.
Topics: Animals; Bicarbonates; Carboxy-Lyases; Chemical and Drug Induced Liver Injury; Cycloheximide; Female; Galactosamine; Glucose; In Vitro Techniques; Kidney; Lactates; Liver; Perfusion; Phosphoenolpyruvate Carboxykinase (GTP); Rats; Starvation; Time Factors | 1973 |
Inhibition of uridine diphosphoglucose dehydrogenase by galactosamine-I-phosphate and UDP-galactosamine.
Topics: Alcohol Oxidoreductases; Animals; Binding, Competitive; Cattle; Chemical and Drug Induced Liver Injury; Galactosamine; Glucose; Kinetics; Liver; Male; Rats; Uridine Diphosphate Sugars | 1973 |
[The anti-hepatotoxic effect of parenterally administered silymarin in galactosamine hepatitis of the rat].
Topics: Alanine Transaminase; Alcohols; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Flavonoids; Galactosamine; Glutamate Dehydrogenase; Injections, Intraperitoneal; Liver; Male; Rats | 1973 |
[The effect of D-penicillamine on the galactosamine hepatitis model in the rat].
Topics: Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Galactosamine; Lipids; Liver; Penicillamine; Rats; Uracil Nucleotides | 1973 |
Prevention of the hepatotoxic effects of D-galactosamine by D-galactose.
Topics: Animals; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; Chromatography, Ion Exchange; Galactosamine; Galactose; In Vitro Techniques; Liver; Male; Mice; Nucleotides; Orotic Acid; Tritium; Uridine; Valine | 1973 |
Studies on hepatic uptake of antigen. II. The effect of hepatotoxins on the immune response.
Topics: Animals; Antibody Formation; Antigens; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromium Radioisotopes; Erythrocytes; Galactosamine; Hemolysin Proteins; Liver; Male; Portal Vein; Rats; Sheep; Vena Cava, Inferior | 1973 |
[Primary and secondary liver response to D-galactosamine administration in galactosamine hepatitis].
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Time Factors | 1973 |
[Relations between phospholipid composition of plasma and liver microsomes in experimental cholestasis and hepatitis].
Topics: Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Galactosamine; Guinea Pigs; Male; Microsomes, Liver; Phospholipids; Rats | 1973 |
[Consumption coagulopathy with fibrin rich microcoagula in experimental rabbit hepatitis].
Topics: Aminocaproates; Animals; Chemical and Drug Induced Liver Injury; Disseminated Intravascular Coagulation; Galactosamine; Heparin; Hepatitis; Rabbits | 1973 |
Rat alpha 1-fetoprotein: appearance after galactosamine-induced liver injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Fetal Proteins; Galactosamine; Liver Regeneration; Male; Rats | 1974 |
Experimental hepatitis induced by D-galactosamine.
Topics: Adenosine Triphosphate; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Galactosamine; Glucose; Guinea Pigs; Liver; Liver Glycogen; Male; Mice; Mice, Inbred Strains; Rabbits; Rats; Rats, Inbred Strains | 1968 |
[Haemostasis during galactosamine hepatitis].
Topics: Animals; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Factor V; Factor VIII; Galactosamine; Hemostasis; Hexosamines; Necrosis; Prothrombin; Rabbits | 1972 |
[Hypovolaemia and haemoconcentration in rats with galactosamine-induced hepatitis].
Topics: Animals; Blood Volume Determination; Body Weight; Chemical and Drug Induced Liver Injury; Erythrocyte Count; Galactosamine; Hematocrit; Hemoglobinometry; Male; Rats; Rats, Inbred Strains; Time Factors | 1972 |
[Acute hepatic disorders].
Topics: Acute Disease; Alcoholism; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Dogs; Galactosamine; Guinea Pigs; Humans; Liver Diseases; Mice; Orotic Acid; Rabbits; Rats | 1972 |
["Galactosamine refractory" regenerating liver--a model for studies on the etiology mechanism of galactosamine hepatitis].
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Liver; Liver Regeneration; Rats; Uracil Nucleotides | 1972 |
[Cholinesterase activity in rabbit plasma after severe hepatic damage caused by D-galactosamine-HCl].
Topics: Acetylcholine; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cholinesterases; Galactosamine; Hexosamines; Liver Diseases; Poisoning; Rabbits; Serum Albumin | 1971 |
[Electron optic studies on galactosamine-induced lesions in the rat liver].
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytoplasm; Disease Models, Animal; Female; Galactosamine; Hexosamines; Liver Diseases; Microscopy, Electron; Mitochondria, Liver; Rats | 1971 |
[Galactosamine hepatitis: injury to the plasma membrane of hepatic cells following administration of D-galactosamine].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cell Membrane; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Nucleotidases; Oxidoreductases; Rats | 1971 |
[Experimental animal studies on giant cell hepatitis in baby rats after galactosamine administration to pregnant rats].
Topics: Animals; Animals, Newborn; Carbon Isotopes; Chemical and Drug Induced Liver Injury; Female; Fetal Diseases; Fetus; Galactosamine; Hexosamines; Liver; Maternal-Fetal Exchange; Pregnancy; Proteins; Rats; Rats, Inbred Strains | 1970 |