galactocerebroside has been researched along with Optic-Nerve-Diseases* in 1 studies
1 other study(ies) available for galactocerebroside and Optic-Nerve-Diseases
Article | Year |
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Galactocerebroside antiserum causes demyelination of cat optic nerve.
A model of immune-mediated optic nerve demyelination is described. Micro-injection of small volumes (less than 5 microliter) of high titer polyclonal anti-Gal-C serum into the cat optic nerve resulted in a focal, highly selective demyelinative lesion followed by remyelination. Demyelination appears to be due to a dual effect on myelin and on oligodendrocytes. The numbers of these cells within the lesion were initially reduced but subsequently increased as remyelination occurred. Topics: Animals; Cats; Cerebrosides; Demyelinating Diseases; Disease Models, Animal; Galactosylceramides; Immune Sera; Microscopy, Electron; Optic Nerve; Optic Nerve Diseases | 1985 |