galactocerebroside and Gangliosidosis--GM1

galactocerebroside has been researched along with Gangliosidosis--GM1* in 1 studies

Other Studies

1 other study(ies) available for galactocerebroside and Gangliosidosis--GM1

Article	Year
Improving the detection of IgM antibodies against glycolipids complexes of GM1 and Galactocerebroside in Multifocal Motor Neuropathy using glycoarray and ELISA assays. Journal of neuroimmunology, 2015, Jan-15, Volume: 278 Antibodies against complexes of GM1:GalC are detected in multifocal motor neuropathy. Previous studies used different techniques, explaining disparities in the results. Antibodies against GM1 and GM1:GalC with different proportions of GalC were measured with both glycoarray and ELISA in 20 multifocal motor neuropathies, and 45 controls. The 1:5 ratio and the 1:1 ratio of GM1:GalC (weight ratio) were respectively the most effective for glycoarray and for ELISA. Testing for anti-GM1:GalC antibodies increased the sensitivity from 40% with anti-GM1 antibodies to 65% with array and 60% with ELISA without loss in specificity (above 91%). Anti-GM1:GalC antibodies are effective biological tools to diagnose multifocal motor neuropathy. Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Enzyme-Linked Immunosorbent Assay; Female; Galactosylceramides; Gangliosidosis, GM1; Humans; Immunoglobulin M; Male; Microarray Analysis; Middle Aged; Polyneuropathies; ROC Curve; Statistics, Nonparametric	2015

Article

Year

Improving the detection of IgM antibodies against glycolipids complexes of GM1 and Galactocerebroside in Multifocal Motor Neuropathy using glycoarray and ELISA assays.

Journal of neuroimmunology, 2015, Jan-15, Volume: 278

Antibodies against complexes of GM1:GalC are detected in multifocal motor neuropathy. Previous studies used different techniques, explaining disparities in the results. Antibodies against GM1 and GM1:GalC with different proportions of GalC were measured with both glycoarray and ELISA in 20 multifocal motor neuropathies, and 45 controls. The 1:5 ratio and the 1:1 ratio of GM1:GalC (weight ratio) were respectively the most effective for glycoarray and for ELISA. Testing for anti-GM1:GalC antibodies increased the sensitivity from 40% with anti-GM1 antibodies to 65% with array and 60% with ELISA without loss in specificity (above 91%). Anti-GM1:GalC antibodies are effective biological tools to diagnose multifocal motor neuropathy.

Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Enzyme-Linked Immunosorbent Assay; Female; Galactosylceramides; Gangliosidosis, GM1; Humans; Immunoglobulin M; Male; Microarray Analysis; Middle Aged; Polyneuropathies; ROC Curve; Statistics, Nonparametric

2015