galactal and Cholestasis--Intrahepatic

To observe the effect of Shuangcao Tuihuang Granule-1 (SCTH-1) in treating severe jaundice of acute icterohepatitis and to study its mechanism.. Thirty-four patients with severe jaundice of acute icterohepatitis were treated with SCTH-1, their therapeutic effects were analyzed. In the experimental studies, the influences of SCTH-1 on acute liver injury, liver superoxide dismutase (SOD) and serum ALT and AST were monitored.. The markedly effective rate and effective rate of the treated group were 73.5% and 23.5% respectively. The markedly effective rate of the treated group was obviously higher than that of the control group (P < 0.05). Experimental study revealed that SCTH-1 could reduce the level of serum transaminase and inflammation of liver tissue in mice with acute liver damage. In addition, SCTH-1 could raise the activity of liver SOD (P < 0.05).. SCTH-1 could accelerate the jaundice subsidence, improve the liver function and ameliorate the liver injury, its mechanism was possibly correlated with raising SOD activity, scavenging the oxygen free radicals.

Topics: Adolescent; Adult; Aged; Animals; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Drugs, Chinese Herbal; Female; Galactose; Hepatitis, Viral, Human; Humans; Male; Mice; Middle Aged; Phytotherapy