gadoxetic-acid-disodium and Common-Bile-Duct-Diseases

Gadolinium-EOB-DTPA (Gd-EOB-DTPA) is a hepatobiliary magnetic resonance (MR) imaging contrast medium designed to detect focal liver lesions. The objective of this study was to evaluate dynamic Gd-EOB-DTPA-enhanced MR imaging as a new method for assessing liver excretory function and to compare it with a scintigraphic method, the gold standard.. Changes in scintigraphic liver activity or MR liver signal intensity were intraindividually monitored over time after intravenous injection of 50 mumol Gd/kg of Gd-EOB-DTPA in controls and rats with common bile duct obstruction or L-ethionine-induced fatty liver (n = 6).. A comparison of liver scintigraphy and MR imaging revealed that elimination half-lives of Gd-EOB-DTPA were significantly longer in rats with common bile duct obstruction (scintigraphy: 100 +/- 27 minutes; MR imaging: 59 +/- 18 minutes) or fatty liver (scintigraphy: 94 +/- 30 minutes; MR imaging: 72 +/- 32 minutes) than in controls (scintigraphy: 20 +/- 2 minutes; MR imaging: 18 +/- 3) (P < 0.05).. Like liver scintigraphy, functional MR liver imaging using Gd-EOB-DTPA is feasible and can differentiate normal controls from models of biliary and hepatocyte disease.

Topics: Animals; Cholestasis; Common Bile Duct Diseases; Contrast Media; Fatty Liver; Female; Gadolinium; Gadolinium DTPA; Half-Life; Image Processing, Computer-Assisted; Liver; Magnetic Resonance Imaging; Organometallic Compounds; Pentetic Acid; Radioisotopes; Radionuclide Imaging; Rats; Rats, Wistar