gadoxetic-acid-disodium and Cholestasis--Intrahepatic

gadoxetic-acid-disodium has been researched along with Cholestasis--Intrahepatic* in 1 studies

Other Studies

1 other study(ies) available for gadoxetic-acid-disodium and Cholestasis--Intrahepatic

Article	Year
MR imaging evaluation of liver enhancement by Gd-EOB-DTPA in selective and total bile duct obstruction in rats: correlation with serologic, microcholangiographic, and histologic findings. Radiology, 1994, Volume: 190, Issue:3 To investigate the behavior and potential application of the hepatobiliary magnetic resonance (MR) imaging contrast agent gadolinium-ethoxybenzyl (EOB)-diethylene-triamine-pentaacetic acid (DTPA) in cholestasis.. Rat models of selective biliary obstruction (SBO) (n = 20) and total biliary obstruction (TBO) (n = 14) were used. Serial Gd-EOB-DTPA-enhanced MR images were obtained, and the findings were correlated with serologic, microcholangiographic, and histologic findings.. In SBO rats, statistically significantly prolonged enhancement of ligated lobes occurred during the acute phase (P < .01) but was absent during the chronic phase owing to bile collateral vessels. In TBO rats, statistically significantly lower liver enhancement (P < .01) was observed as long as the obstruction persisted, until collateral bile ducts developed.. The distinction between obstructed and unobstructed liver on Gd-EOB-DTPA-enhanced MR images suggests a novel application for visualizing cholestasis. Topics: Animals; Bile Ducts, Extrahepatic; Bile Ducts, Intrahepatic; Cholestasis; Cholestasis, Intrahepatic; Contrast Media; Gadolinium; Gadolinium DTPA; Liver; Magnetic Resonance Imaging; Male; Organometallic Compounds; Pentetic Acid; Rats; Rats, Wistar	1994

Article

Year

MR imaging evaluation of liver enhancement by Gd-EOB-DTPA in selective and total bile duct obstruction in rats: correlation with serologic, microcholangiographic, and histologic findings.

Radiology, 1994, Volume: 190, Issue:3

To investigate the behavior and potential application of the hepatobiliary magnetic resonance (MR) imaging contrast agent gadolinium-ethoxybenzyl (EOB)-diethylene-triamine-pentaacetic acid (DTPA) in cholestasis.. Rat models of selective biliary obstruction (SBO) (n = 20) and total biliary obstruction (TBO) (n = 14) were used. Serial Gd-EOB-DTPA-enhanced MR images were obtained, and the findings were correlated with serologic, microcholangiographic, and histologic findings.. In SBO rats, statistically significantly prolonged enhancement of ligated lobes occurred during the acute phase (P < .01) but was absent during the chronic phase owing to bile collateral vessels. In TBO rats, statistically significantly lower liver enhancement (P < .01) was observed as long as the obstruction persisted, until collateral bile ducts developed.. The distinction between obstructed and unobstructed liver on Gd-EOB-DTPA-enhanced MR images suggests a novel application for visualizing cholestasis.

Topics: Animals; Bile Ducts, Extrahepatic; Bile Ducts, Intrahepatic; Cholestasis; Cholestasis, Intrahepatic; Contrast Media; Gadolinium; Gadolinium DTPA; Liver; Magnetic Resonance Imaging; Male; Organometallic Compounds; Pentetic Acid; Rats; Rats, Wistar

1994