gadoxetic-acid-disodium and Chemical-and-Drug-Induced-Liver-Injury--Chronic

Oxaliplatin-induced liver injury (OILI) not only impairs hepatic regeneration but also increases postoperative morbidity and mortality. Therefore, noninvasive, accurate, and early diagnosis of OILI is mandatory.. To evaluate the potential of T. Case control, animal model.. Thirty oxaliplatin-treated mice and 10 control mice were included.. Volumetric interpolated breath-hold examination sequence: 3T scanner with a phased-array animal 8-channel coil. T. T. The Kruskal-Wallis test with pairwise comparisons using the Mann-Whitney U-test were applied to compare the parameters across groups. Spearman's rank correlation test and receiver operating characteristics (ROC) analyses were performed. Areas under the curves (AUCs) were compared using the DeLong method.. Histologically, mice were classified as normal (n = 10), hepatocellular degeneration without fibrosis (n = 16), and hepatocellular degeneration with fibrosis (n = 14). HBP T. HBP T. 2.. 5.

Topics: Animals; Chemical and Drug Induced Liver Injury, Chronic; Contrast Media; Gadolinium DTPA; Liver; Magnetic Resonance Imaging; Mice; Oxaliplatin

Topics: Animals; Chemical and Drug Induced Liver Injury, Chronic; Contrast Media; Gadolinium DTPA; Liver; Liver Neoplasms; Magnetic Resonance Imaging; Mice; Oxaliplatin