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gaboxadol and Seizures

gaboxadol has been researched along with Seizures in 20 studies

gaboxadol: GABA agonist; inhibitor of GABA uptake systems; structure

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
" Our previous work indicates that in 16-day-old rat pups, nigral administration of the GABAA receptor agonist muscimol facilitates flurothyl-induced seizures, whereas it suppresses seizures in adult rats."7.68The proconvulsant effect of nigral infusions of THIP on flurothyl-induced seizures in rat pups. ( Garant, DS; Moshé, SL; Sperber, EF; Xu, SG, 1992)
"Intraperitoneal injection of ethanol (1-2 g/kg) and chlordiazepoxide (2-16 mg/kg) suppressed susceptibility to audiogenically induced, clonic-tonic seizures and antagonized forelimb tremor in rats undergoing ethanol withdrawal, 30 min after treatment."7.66Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors. ( Breese, GR; Frye, GD; McCown, TJ, 1983)
" Our previous work indicates that in 16-day-old rat pups, nigral administration of the GABAA receptor agonist muscimol facilitates flurothyl-induced seizures, whereas it suppresses seizures in adult rats."3.68The proconvulsant effect of nigral infusions of THIP on flurothyl-induced seizures in rat pups. ( Garant, DS; Moshé, SL; Sperber, EF; Xu, SG, 1992)
"The effects of three specific GABA receptor agonists, muscimol, progabide, and gaboxadol, on kindled seizures were evaluated in amygdala-kindled rats."3.67Evaluation of different GABA receptor agonists in the kindled amygdala seizure model in rats. ( Löscher, W; Schwark, WS, 1985)
"The anticonvulsant efficacy of the GABAmimetic drugs cetyl GABA, progabide and THIP (4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridine-3-ol) was studied against minor (myoclonic) and major (generalized tonic-clonic) seizures in gerbils as well as against maximal electroshock and s."3.67Anticonvulsant action of GABA agonists and prodrugs on minor and major seizures in epileptic gerbils. Comparison with mouse models of seizure states. ( Löscher, W, 1985)
"Intraperitoneal injection of ethanol (1-2 g/kg) and chlordiazepoxide (2-16 mg/kg) suppressed susceptibility to audiogenically induced, clonic-tonic seizures and antagonized forelimb tremor in rats undergoing ethanol withdrawal, 30 min after treatment."3.66Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors. ( Breese, GR; Frye, GD; McCown, TJ, 1983)
"Seven GABAmimetic drugs, namely cetyl gamma-aminobutyric acid (cetyl GABA), 4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridine-3-ol, progabide, aminooxyacetic acid, alpha-acetylenic GABA, (-)-nipecotic acid ethyl ester and (+/-)-cis-4-hydroxynipecotic acid methyl ester, were tested for their potency to block "major" (generalized clonic-tonic) seizures in gerbils, induced by blowing at the animals with compressed air."3.66High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy. ( Frey, HH; Löscher, W; Reiche, R; Schultz, D, 1983)
"8."1.43Pubertal Expression of α4βδ GABAA Receptors Reduces Seizure-Like Discharges in CA1 Hippocampus. ( Merlin, LR; Shen, H; Smith, SS; Yang, L, 2016)
" Sleep EEG studies demonstrated lack of tolerance and withdrawal effects after 28 daily doses with gaboxadol, whereas zolpidem produced both tolerance and withdrawal effects under a similar dosing regimen."1.35Gaboxadol -- a different hypnotic profile with no tolerance to sleep EEG and sedative effects after repeated daily dosing. ( Anderson, NJ; Cremers, TI; Ebert, B; Fahey, JM; Rasmussen, S; Sánchez, C; Vogel, V, 2008)
"Naloxone displayed a seizure-suppressant effect that was delayed and incomplete."1.30The periaqueductal grey is a critical site in the neuronal network for audiogenic seizures: modulation by GABA(A), NMDA and opioid receptors. ( Faingold, CL; N'Gouemo, P, 1999)
" In the flurothyl seizure model, SNR microinjection of the selective GABAA receptor agonist muscimol results in a biphasic dose-response curve in adults: Intermediate doses are anticonvulsant, but high doses have proconvulsant effects."1.29Age-related differences in the effects of GABAA agonists microinjected into rat substantia nigra: pro- and anticonvulsant actions. ( Garant, DS; Moshé, SL; Sperber, EF; Xu, SG, 1995)
"Pentobarbital was also effective against bicuculline whereas only hypnotic doses of phenobarbital provided some protection against bicuculline- (8 mg/kg, IP) induced convulsions."1.27Interactions of pentobarbital and phenobarbital with GABAergic drugs against chemoconvulsants in rats. ( Mehta, AK; Ticku, MK, 1988)
" THIP, even at toxic doses, did not alter the anti-PTZ activity of either pentobarbital or phenobarbital."1.27Effects of gamma-aminobutyric acid (GABA) receptor agonists on the neurotoxicity and anticonvulsant activity of barbiturates in mice. ( Chweh, AY; Swinyard, EA; Ulloque, RA, 1986)
"The acute administration of an anticonvulsant dose of ethosuximide (150 mg/kg) had no effect on brain gamma-aminobutyric acid (GABA) concentration, whereas a toxic dose (400 mg/kg) increased significantly the concentration of brain GABA (1."1.27Effect of ethosuximide alone and in combination with gamma-aminobutyric acid receptor agonists on brain gamma-aminobutyric acid concentration, anticonvulsant activity and neurotoxicity in mice. ( Chweh, AY; Lin-Michell, E; Swinyard, EA, 1986)
"No protection against seizures was seen after THIP, 1-4 mg/kg, intraperitoneally in mice."1.26Effects of the bicyclic GABA agonist, THIP, on myoclonic and seizure responses in mice and baboons with reflex epilepsy. ( Horton, R; Meldrum, B, 1980)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-199012 (60.00)18.7374
1990's3 (15.00)18.2507
2000's1 (5.00)29.6817
2010's4 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sun, Y1
Wu, Z2
Kong, S2
Jiang, D1
Pitre, A1
Wang, Y2
Chen, G1
Medrihan, L1
Ferrea, E1
Greco, B1
Baldelli, P1
Benfenati, F1
Wan, L1
Liu, X1
Ren, W1
Dargham, RA1
Cheng, L1
Yang, L1
Shen, H1
Merlin, LR1
Smith, SS1
Ebert, B1
Anderson, NJ1
Cremers, TI1
Rasmussen, S1
Vogel, V1
Fahey, JM1
Sánchez, C1
Minchin, MC1
Nutt, DJ1
Frye, GD1
McCown, TJ1
Breese, GR1
Löscher, W3
Frey, HH1
Reiche, R1
Schultz, D1
Golden, GT1
Fariello, RG1
Meldrum, B1
Horton, R1
Garant, DS2
Xu, SG2
Sperber, EF2
Moshé, SL2
N'Gouemo, P1
Faingold, CL1
Mehta, AK1
Ticku, MK1
Meldrum, BS1
Bagri, A1
Sandner, G1
Di Scala, G1
Schwark, WS1
Ulloque, RA1
Chweh, AY2
Swinyard, EA2
Lin-Michell, E1

Reviews

1 review available for gaboxadol and Seizures

ArticleYear
Drugs acting on amino acid neurotransmitters.
    Advances in neurology, 1986, Volume: 43

    Topics: Acoustic Stimulation; Amino Acids; Animals; Chemical Phenomena; Chemistry; Diazepam; Electrophysiolo

1986

Other Studies

19 other studies available for gaboxadol and Seizures

ArticleYear
Regulation of epileptiform activity by two distinct subtypes of extrasynaptic GABAA receptors.
    Molecular brain, 2013, May-01, Volume: 6

    Topics: Animals; Benzothiadiazines; Cells, Cultured; Epilepsy; Female; gamma-Aminobutyric Acid; HEK293 Cells

2013
Asynchronous GABA Release Is a Key Determinant of Tonic Inhibition and Controls Neuronal Excitability: A Study in the Synapsin II-/- Mouse.
    Cerebral cortex (New York, N.Y. : 1991), 2015, Volume: 25, Issue:10

    Topics: Action Potentials; Animals; Excitatory Postsynaptic Potentials; GABA Agonists; gamma-Aminobutyric Ac

2015
Activation of extrasynaptic GABA(A) receptors inhibits cyclothiazide-induced epileptiform activity in hippocampal CA1 neurons.
    Neuroscience bulletin, 2014, Volume: 30, Issue:5

    Topics: Animals; Benzothiadiazines; CA1 Region, Hippocampal; Convulsants; Disease Models, Animal; GABA Agoni

2014
Pubertal Expression of α4βδ GABAA Receptors Reduces Seizure-Like Discharges in CA1 Hippocampus.
    Scientific reports, 2016, 08-26, Volume: 6

    Topics: Age Factors; Animals; Benzamides; CA1 Region, Hippocampal; Cations, Monovalent; Evoked Potentials; F

2016
Gaboxadol -- a different hypnotic profile with no tolerance to sleep EEG and sedative effects after repeated daily dosing.
    Pharmacology, biochemistry, and behavior, 2008, Volume: 90, Issue:1

    Topics: Anesthetics; Animals; Bicuculline; Central Nervous System; Dose-Response Relationship, Drug; Down-Re

2008
The effect of repeated electroconvulsive shock on the function of THIP, a GABA agonist.
    Pharmacology, biochemistry, and behavior, 1984, Volume: 21, Issue:4

    Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Dose-Response Relationship, Drug; Electroshock; Isoxa

1984
Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 226, Issue:3

    Topics: 4-Aminobutyrate Transaminase; Acoustic Stimulation; Aminobutyrates; Animals; Chlordiazepoxide; Disea

1983
High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 226, Issue:3

    Topics: Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Diazepam; Disease Models, An

1983
Penicillin spikes in rats. Limitations of a simple model for the study of anticonvulsants.
    Neuropharmacology, 1984, Volume: 23, Issue:9

    Topics: Action Potentials; Animals; Anticonvulsants; Dimethyl Sulfoxide; Disease Models, Animal; Drug Evalua

1984
Effects of the bicyclic GABA agonist, THIP, on myoclonic and seizure responses in mice and baboons with reflex epilepsy.
    European journal of pharmacology, 1980, Feb-08, Volume: 61, Issue:3

    Topics: Animals; Anticonvulsants; Electroencephalography; gamma-Aminobutyric Acid; Haplorhini; Isoxazoles; M

1980
Age-related differences in the effects of GABAA agonists microinjected into rat substantia nigra: pro- and anticonvulsant actions.
    Epilepsia, 1995, Volume: 36, Issue:10

    Topics: Age Factors; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Flurothyl; GABA Agonists;

1995
The periaqueductal grey is a critical site in the neuronal network for audiogenic seizures: modulation by GABA(A), NMDA and opioid receptors.
    Epilepsy research, 1999, Volume: 35, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagoni

1999
The proconvulsant effect of nigral infusions of THIP on flurothyl-induced seizures in rat pups.
    Brain research. Developmental brain research, 1992, Aug-21, Volume: 68, Issue:2

    Topics: Animals; Convulsants; Dose-Response Relationship, Drug; Drug Synergism; Flurothyl; Infusions, Parent

1992
Interactions of pentobarbital and phenobarbital with GABAergic drugs against chemoconvulsants in rats.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 30, Issue:4

    Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Convulsants; Diazepam; Drug Interactions; Isoxazole

1988
Effects of unilateral microinjections of GABAergic drugs into the inferior colliculus on auditory evoked potentials and on audiogenic seizure susceptibility.
    Experimental neurology, 1989, Volume: 104, Issue:1

    Topics: Acoustic Stimulation; Animals; Anticonvulsants; Bicuculline; Evoked Potentials, Auditory; Functional

1989
Evaluation of different GABA receptor agonists in the kindled amygdala seizure model in rats.
    Experimental neurology, 1985, Volume: 89, Issue:2

    Topics: Amygdala; Animals; Female; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Isoxazoles; Kindling, N

1985
Effects of gamma-aminobutyric acid (GABA) receptor agonists on the neurotoxicity and anticonvulsant activity of barbiturates in mice.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 237, Issue:2

    Topics: Animals; Anticonvulsants; Baclofen; Barbiturates; Dose-Response Relationship, Drug; Drug Synergism;

1986
Effect of ethosuximide alone and in combination with gamma-aminobutyric acid receptor agonists on brain gamma-aminobutyric acid concentration, anticonvulsant activity and neurotoxicity in mice.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 237, Issue:2

    Topics: Animals; Brain Chemistry; Ethosuximide; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Mice, Inbre

1986
Anticonvulsant action of GABA agonists and prodrugs on minor and major seizures in epileptic gerbils. Comparison with mouse models of seizure states.
    Archives internationales de pharmacodynamie et de therapie, 1985, Volume: 276, Issue:2

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Female; gamma-Aminobutyric Acid; Ger

1985