gaboxadol has been researched along with Seizures in 20 studies
gaboxadol: GABA agonist; inhibitor of GABA uptake systems; structure
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Our previous work indicates that in 16-day-old rat pups, nigral administration of the GABAA receptor agonist muscimol facilitates flurothyl-induced seizures, whereas it suppresses seizures in adult rats." | 7.68 | The proconvulsant effect of nigral infusions of THIP on flurothyl-induced seizures in rat pups. ( Garant, DS; Moshé, SL; Sperber, EF; Xu, SG, 1992) |
| "Intraperitoneal injection of ethanol (1-2 g/kg) and chlordiazepoxide (2-16 mg/kg) suppressed susceptibility to audiogenically induced, clonic-tonic seizures and antagonized forelimb tremor in rats undergoing ethanol withdrawal, 30 min after treatment." | 7.66 | Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors. ( Breese, GR; Frye, GD; McCown, TJ, 1983) |
| " Our previous work indicates that in 16-day-old rat pups, nigral administration of the GABAA receptor agonist muscimol facilitates flurothyl-induced seizures, whereas it suppresses seizures in adult rats." | 3.68 | The proconvulsant effect of nigral infusions of THIP on flurothyl-induced seizures in rat pups. ( Garant, DS; Moshé, SL; Sperber, EF; Xu, SG, 1992) |
| "The effects of three specific GABA receptor agonists, muscimol, progabide, and gaboxadol, on kindled seizures were evaluated in amygdala-kindled rats." | 3.67 | Evaluation of different GABA receptor agonists in the kindled amygdala seizure model in rats. ( Löscher, W; Schwark, WS, 1985) |
| "The anticonvulsant efficacy of the GABAmimetic drugs cetyl GABA, progabide and THIP (4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridine-3-ol) was studied against minor (myoclonic) and major (generalized tonic-clonic) seizures in gerbils as well as against maximal electroshock and s." | 3.67 | Anticonvulsant action of GABA agonists and prodrugs on minor and major seizures in epileptic gerbils. Comparison with mouse models of seizure states. ( Löscher, W, 1985) |
| "Intraperitoneal injection of ethanol (1-2 g/kg) and chlordiazepoxide (2-16 mg/kg) suppressed susceptibility to audiogenically induced, clonic-tonic seizures and antagonized forelimb tremor in rats undergoing ethanol withdrawal, 30 min after treatment." | 3.66 | Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors. ( Breese, GR; Frye, GD; McCown, TJ, 1983) |
| "Seven GABAmimetic drugs, namely cetyl gamma-aminobutyric acid (cetyl GABA), 4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridine-3-ol, progabide, aminooxyacetic acid, alpha-acetylenic GABA, (-)-nipecotic acid ethyl ester and (+/-)-cis-4-hydroxynipecotic acid methyl ester, were tested for their potency to block "major" (generalized clonic-tonic) seizures in gerbils, induced by blowing at the animals with compressed air." | 3.66 | High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy. ( Frey, HH; Löscher, W; Reiche, R; Schultz, D, 1983) |
| "8." | 1.43 | Pubertal Expression of α4βδ GABAA Receptors Reduces Seizure-Like Discharges in CA1 Hippocampus. ( Merlin, LR; Shen, H; Smith, SS; Yang, L, 2016) |
| " Sleep EEG studies demonstrated lack of tolerance and withdrawal effects after 28 daily doses with gaboxadol, whereas zolpidem produced both tolerance and withdrawal effects under a similar dosing regimen." | 1.35 | Gaboxadol -- a different hypnotic profile with no tolerance to sleep EEG and sedative effects after repeated daily dosing. ( Anderson, NJ; Cremers, TI; Ebert, B; Fahey, JM; Rasmussen, S; Sánchez, C; Vogel, V, 2008) |
| "Naloxone displayed a seizure-suppressant effect that was delayed and incomplete." | 1.30 | The periaqueductal grey is a critical site in the neuronal network for audiogenic seizures: modulation by GABA(A), NMDA and opioid receptors. ( Faingold, CL; N'Gouemo, P, 1999) |
| " In the flurothyl seizure model, SNR microinjection of the selective GABAA receptor agonist muscimol results in a biphasic dose-response curve in adults: Intermediate doses are anticonvulsant, but high doses have proconvulsant effects." | 1.29 | Age-related differences in the effects of GABAA agonists microinjected into rat substantia nigra: pro- and anticonvulsant actions. ( Garant, DS; Moshé, SL; Sperber, EF; Xu, SG, 1995) |
| "Pentobarbital was also effective against bicuculline whereas only hypnotic doses of phenobarbital provided some protection against bicuculline- (8 mg/kg, IP) induced convulsions." | 1.27 | Interactions of pentobarbital and phenobarbital with GABAergic drugs against chemoconvulsants in rats. ( Mehta, AK; Ticku, MK, 1988) |
| " THIP, even at toxic doses, did not alter the anti-PTZ activity of either pentobarbital or phenobarbital." | 1.27 | Effects of gamma-aminobutyric acid (GABA) receptor agonists on the neurotoxicity and anticonvulsant activity of barbiturates in mice. ( Chweh, AY; Swinyard, EA; Ulloque, RA, 1986) |
| "The acute administration of an anticonvulsant dose of ethosuximide (150 mg/kg) had no effect on brain gamma-aminobutyric acid (GABA) concentration, whereas a toxic dose (400 mg/kg) increased significantly the concentration of brain GABA (1." | 1.27 | Effect of ethosuximide alone and in combination with gamma-aminobutyric acid receptor agonists on brain gamma-aminobutyric acid concentration, anticonvulsant activity and neurotoxicity in mice. ( Chweh, AY; Lin-Michell, E; Swinyard, EA, 1986) |
| "No protection against seizures was seen after THIP, 1-4 mg/kg, intraperitoneally in mice." | 1.26 | Effects of the bicyclic GABA agonist, THIP, on myoclonic and seizure responses in mice and baboons with reflex epilepsy. ( Horton, R; Meldrum, B, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (60.00) | 18.7374 |
| 1990's | 3 (15.00) | 18.2507 |
| 2000's | 1 (5.00) | 29.6817 |
| 2010's | 4 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, Y | 1 |
| Wu, Z | 2 |
| Kong, S | 2 |
| Jiang, D | 1 |
| Pitre, A | 1 |
| Wang, Y | 2 |
| Chen, G | 1 |
| Medrihan, L | 1 |
| Ferrea, E | 1 |
| Greco, B | 1 |
| Baldelli, P | 1 |
| Benfenati, F | 1 |
| Wan, L | 1 |
| Liu, X | 1 |
| Ren, W | 1 |
| Dargham, RA | 1 |
| Cheng, L | 1 |
| Yang, L | 1 |
| Shen, H | 1 |
| Merlin, LR | 1 |
| Smith, SS | 1 |
| Ebert, B | 1 |
| Anderson, NJ | 1 |
| Cremers, TI | 1 |
| Rasmussen, S | 1 |
| Vogel, V | 1 |
| Fahey, JM | 1 |
| Sánchez, C | 1 |
| Minchin, MC | 1 |
| Nutt, DJ | 1 |
| Frye, GD | 1 |
| McCown, TJ | 1 |
| Breese, GR | 1 |
| Löscher, W | 3 |
| Frey, HH | 1 |
| Reiche, R | 1 |
| Schultz, D | 1 |
| Golden, GT | 1 |
| Fariello, RG | 1 |
| Meldrum, B | 1 |
| Horton, R | 1 |
| Garant, DS | 2 |
| Xu, SG | 2 |
| Sperber, EF | 2 |
| Moshé, SL | 2 |
| N'Gouemo, P | 1 |
| Faingold, CL | 1 |
| Mehta, AK | 1 |
| Ticku, MK | 1 |
| Meldrum, BS | 1 |
| Bagri, A | 1 |
| Sandner, G | 1 |
| Di Scala, G | 1 |
| Schwark, WS | 1 |
| Ulloque, RA | 1 |
| Chweh, AY | 2 |
| Swinyard, EA | 2 |
| Lin-Michell, E | 1 |
1 review available for gaboxadol and Seizures
| Article | Year |
|---|---|
Drugs acting on amino acid neurotransmitters.
Topics: Acoustic Stimulation; Amino Acids; Animals; Chemical Phenomena; Chemistry; Diazepam; Electrophysiolo | 1986 |
19 other studies available for gaboxadol and Seizures
| Article | Year |
|---|---|
Regulation of epileptiform activity by two distinct subtypes of extrasynaptic GABAA receptors.
Topics: Animals; Benzothiadiazines; Cells, Cultured; Epilepsy; Female; gamma-Aminobutyric Acid; HEK293 Cells | 2013 |
Asynchronous GABA Release Is a Key Determinant of Tonic Inhibition and Controls Neuronal Excitability: A Study in the Synapsin II-/- Mouse.
Topics: Action Potentials; Animals; Excitatory Postsynaptic Potentials; GABA Agonists; gamma-Aminobutyric Ac | 2015 |
Activation of extrasynaptic GABA(A) receptors inhibits cyclothiazide-induced epileptiform activity in hippocampal CA1 neurons.
Topics: Animals; Benzothiadiazines; CA1 Region, Hippocampal; Convulsants; Disease Models, Animal; GABA Agoni | 2014 |
Pubertal Expression of α4βδ GABAA Receptors Reduces Seizure-Like Discharges in CA1 Hippocampus.
Topics: Age Factors; Animals; Benzamides; CA1 Region, Hippocampal; Cations, Monovalent; Evoked Potentials; F | 2016 |
Gaboxadol -- a different hypnotic profile with no tolerance to sleep EEG and sedative effects after repeated daily dosing.
Topics: Anesthetics; Animals; Bicuculline; Central Nervous System; Dose-Response Relationship, Drug; Down-Re | 2008 |
The effect of repeated electroconvulsive shock on the function of THIP, a GABA agonist.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Dose-Response Relationship, Drug; Electroshock; Isoxa | 1984 |
Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors.
Topics: 4-Aminobutyrate Transaminase; Acoustic Stimulation; Aminobutyrates; Animals; Chlordiazepoxide; Disea | 1983 |
High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy.
Topics: Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Diazepam; Disease Models, An | 1983 |
Penicillin spikes in rats. Limitations of a simple model for the study of anticonvulsants.
Topics: Action Potentials; Animals; Anticonvulsants; Dimethyl Sulfoxide; Disease Models, Animal; Drug Evalua | 1984 |
Effects of the bicyclic GABA agonist, THIP, on myoclonic and seizure responses in mice and baboons with reflex epilepsy.
Topics: Animals; Anticonvulsants; Electroencephalography; gamma-Aminobutyric Acid; Haplorhini; Isoxazoles; M | 1980 |
Age-related differences in the effects of GABAA agonists microinjected into rat substantia nigra: pro- and anticonvulsant actions.
Topics: Age Factors; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Flurothyl; GABA Agonists; | 1995 |
The periaqueductal grey is a critical site in the neuronal network for audiogenic seizures: modulation by GABA(A), NMDA and opioid receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagoni | 1999 |
The proconvulsant effect of nigral infusions of THIP on flurothyl-induced seizures in rat pups.
Topics: Animals; Convulsants; Dose-Response Relationship, Drug; Drug Synergism; Flurothyl; Infusions, Parent | 1992 |
Interactions of pentobarbital and phenobarbital with GABAergic drugs against chemoconvulsants in rats.
Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Convulsants; Diazepam; Drug Interactions; Isoxazole | 1988 |
Effects of unilateral microinjections of GABAergic drugs into the inferior colliculus on auditory evoked potentials and on audiogenic seizure susceptibility.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Bicuculline; Evoked Potentials, Auditory; Functional | 1989 |
Evaluation of different GABA receptor agonists in the kindled amygdala seizure model in rats.
Topics: Amygdala; Animals; Female; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Isoxazoles; Kindling, N | 1985 |
Effects of gamma-aminobutyric acid (GABA) receptor agonists on the neurotoxicity and anticonvulsant activity of barbiturates in mice.
Topics: Animals; Anticonvulsants; Baclofen; Barbiturates; Dose-Response Relationship, Drug; Drug Synergism; | 1986 |
Effect of ethosuximide alone and in combination with gamma-aminobutyric acid receptor agonists on brain gamma-aminobutyric acid concentration, anticonvulsant activity and neurotoxicity in mice.
Topics: Animals; Brain Chemistry; Ethosuximide; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Mice, Inbre | 1986 |
Anticonvulsant action of GABA agonists and prodrugs on minor and major seizures in epileptic gerbils. Comparison with mouse models of seizure states.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Female; gamma-Aminobutyric Acid; Ger | 1985 |