gaboxadol has been researched along with Muscular Dystrophy, Duchenne in 2 studies
gaboxadol: GABA agonist; inhibitor of GABA uptake systems; structure
Muscular Dystrophy, Duchenne: An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alterations in the Duchenne muscular dystrophy (DMD) gene have been associated with enhanced stress reactivity in vertebrate species, suggesting a role for brain dystrophin in fear-related behavioral and cognitive processes." | 1.46 | Relationships linking emotional, motor, cognitive and GABAergic dysfunctions in dystrophin-deficient mdx mice. ( Chaussenot, R; Vaillend, C, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vaillend, C | 1 |
| Chaussenot, R | 1 |
| Kueh, SL | 1 |
| Dempster, J | 1 |
| Head, SI | 1 |
| Morley, JW | 1 |
2 other studies available for gaboxadol and Muscular Dystrophy, Duchenne
| Article | Year |
|---|---|
Relationships linking emotional, motor, cognitive and GABAergic dysfunctions in dystrophin-deficient mdx mice.
Topics: Animals; Brain; Cognition; Disease Models, Animal; Dystrophin; Fear; GABAergic Neurons; Humans; Isox | 2017 |
Reduced postsynaptic GABAA receptor number and enhanced gaboxadol induced change in holding currents in Purkinje cells of the dystrophin-deficient mdx mouse.
Topics: Animals; Disease Models, Animal; Female; GABA Agonists; GABA Antagonists; Isoxazoles; Male; Mice; Mi | 2011 |